286 results about "Drug" patented technology

The present application relates to a kind of robecoxib liposome and its preparation method and application, the preparation raw material of the robecoxib liposome includes phospholipid, cholesterol and robecoxib, and the robecoxib is encapsulated in lipid bilayer, and the robecoxib liposome of the present application improves the solubility of robecoxib, and has higher encapsulation efficiency and drug loading.

Based on co-drugs representing two different chemical entities and the co- and sequential administration of the two chemical entities, novel therapies for macular degeneration and TTR amyloidosis are provided. The first component (“selective TTR ligand”) is a chemical entity that binds to TTR in the RBP4 (retinol-binding protein 4)-TTR (transthyretin) complex, which participates in the delivery of retinol to the retina. This component reduces retinol transport from circulation to the retina and provides stabilization of the TTR tetramer. The second component (“C20-D3-visual chromophore-generating compound”) is a C20-D3 modified retinoid or carotenoid that, when metabolized in mammals, ultimately produces a C20-D3 visual chromophore, which is presented in the retina as C20-D3-9-cis-retinal or C20-D3-11-cis-retinal. Deuteration at C20 reduces the formation of lipofuscin biretinol, but other functions (such as providing a precursor for the synthesis of the visual chromophore 11-cis-retinaldehyde in vivo) are not reduced.

This invention relates to the field of medical big data analysis technology, and particularly to a machine learning-based method for predicting the risk of drug-induced liver injury (HILI) related to traditional Chinese medicine (TCM). The invention includes the following steps: Step S1: Collect clinical data and divide it into training and test sets; use literature case reports as an external validation set; Step S2: Perform statistical inter-group comparisons based on standardized training set data to screen for independent risk factors; Step S3: Based on the XGBoost model, construct early warning models for HILI related to TCM and select the optimal prediction model; Step S4: Use the SHAP interpreter to interpret the optimal prediction model; Step S5: Input clinical data into the optimal prediction model and output the patient's risk probability. The purpose of this invention is to provide a machine learning-based method for predicting the risk of HILI related to TCM, addressing the problems of low prediction accuracy, lack of interpretability in existing models, and difficulty in accurately predicting the risk of HILI.

This invention discloses a multi-stage dosing device and method for a concentrated liquid flocculation tank, relating to the technical field of dosing equipment. It includes: a fixed frame, disposed on the top of the tank, with a track rod fixedly connected to the end of the fixed frame, and a housing slidably connected to the track rod; a ring-shaped airbag fixedly connected to the top edge of the housing; a dosing device, arranged in a circumferential array on the housing, comprising: a ring pipe, with a delivery pipe circumferentially connected to the ring pipe, one end of the delivery pipe connected to the ring pipe and the other end fixedly connected to the housing and extending into the tank; an inlet device for supplying the drug solution to the ring pipe; and a slow-release device, arranged in a circumferential array on the housing, with an opening and closing device on the housing for adjusting the drug output of the slow-release device.

FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl

The application relates to the technical field of sialic acid application, in particular to application of sialic acid in promoting iron absorption of iron supplement agents. It is found for the first time that sialic acid with a daily intake of 0.8-3.5 mg / kg and ferrous iron with a daily intake of 0.2-0.5 mg / kg can promote the absorption of ferrous iron by human bodies. More specifically, the application claims an iron supplement agent containing ferrous iron drugs and sialic acid. The iron supplement agent provided by the application promotes iron supplement by compounding sialic acid and ferrous iron drugs, thereby improving the bioavailability of iron, regulating immunity, promoting intestinal health and achieving various biological activities while supplementing iron.

This invention belongs to the field of biomedical technology and relates to the application of YMRFamide short peptide in anti-inflammation. The amino acid sequence of the YMRFamide short peptide is Tyr-Met-Arg-Phe. This invention provides a complete solid-phase synthesis and purification method for this peptide, including using Fmoc-Phe-Wang resin as a starting material, sequentially linking arginine, methionine, and tyrosine, followed by deprotection, resin cleavage, and activated carbon-ethanol crystallization purification steps to finally obtain a high-purity YMRFamide short peptide. The preparation process of this invention is simple, efficient, and reproducible, with significantly improved product stability and solubility. The YMRFamide short peptide exhibits multi-pathway anti-inflammatory potential, is expected to effectively regulate the expression of inflammatory factors, and has high biocompatibility and good safety, providing an important candidate molecule for the development of novel anti-inflammatory drugs.

The application discloses an animal model and a detection method for evaluating the effects of a substance on hair growth and / or coloring. The evaluation steps are as follows: the experimental animal is plucked, and then the substance to be evaluated is injected into the tentacle pad or the mustache pad or the hair follicle cavity on one side of the experimental animal, and a control solution is injected into the tentacle pad or the mustache pad or the opposite symmetrical hair follicle cavity on the other side of the experimental animal; after a certain number of injections, the hair on the side injected with the control solution grows, while the hair on the side injected with the solution containing the substance to be evaluated grows or does not grow; the length and / or coloring of the grown hair are quantitatively detected and compared, so that the effects of the substance on hair growth and / or coloring can be accurately evaluated. The application utilizes the symmetry of the hair of the experimental animal, and a simple, direct and high-sensitivity method for quantitatively evaluating the effects of a substance on hair growth in vivo is obtained, which can be used for the research on skin diseases and the development of related drugs, cosmetics and the like, and has important scientific significance and application value.

This invention belongs to the field of biomedical technology and provides a polypeptide with ATG8 protein binding activity, comprising the following structure: X1-X2-X3-X4-X5-X6-X7; wherein: X1, X2, and X3 are independently selected from glutamic acid or are absent; X4 is selected from tryptophan, phenylalanine, or leucine; X5 is valine; X6 is selected from leucine, isoleucine, or valine; and X7 is selected from valine, tryptophan, phenylalanine, or tyrosine. Compared with existing autophagy inhibitors, this polypeptide has the following superior pharmacokinetic potential and development flexibility in terms of target selection, binding strength, and mechanism of action: the short sequence not only reduces synthesis costs but also leaves more room for modification, which is expected to significantly improve the metabolic stability and drug-likeness potential of the polypeptide; it can serve as a highly efficient ATG8 targeting ligand and can be widely used in the construction of biochemical probes, screening of PPI competitive inhibitors, and the development of targeted delivery systems.

The application belongs to the technical field of analysis and detection, and discloses a chiral detection platform based on a hydrogel SERS chip and application thereof.The core of the application is that the inherent chiral structure of a hydrogel matrix in a specific hydrogel SERS chip is found and utilized for the first time, so that specific enantiomers of chiral molecules can be directly and highly selectively recognized and detected without any exogenous chiral modifier or complex separation process.When the chip is used for detection with levomeprazole as a model analyte, only levomeprazole can be selectively adsorbed and produce a strong characteristic SERS signal, and the response of the dextrogyratory enantiomer is weak under the optimal conditions of an acid medium with pH 4.The sensor constructed by the method exhibits high sensitivity to levomeprazole, and the detection limit reaches 1.0x10 ‑7 mol / L, excellent selectivity and good anti-biological matrix interference capability, thereby providing a novel, simple and efficient solution for rapid analysis of chiral drugs.

The present invention relates to compositions comprising at least one lipid-lowering drug or a derivative thereof for the treatment of skin diseases or disorders. In various aspects of the invention, the composition further comprises at least one lipid or a derivative thereof.

This invention belongs to the field of pharmaceutical technology, specifically relating to an alginate oligosaccharide, its preparation method, and its applications. Using brown algae as raw material, the invention first removes impurities from the algae, then extracts it through subcritical acid water, followed by neutralization, decolorization, heavy metal removal, membrane ultrafiltration / nanofiltration purification, and spray drying to obtain high-purity saturated alginate oligosaccharides with a specific degree of polymerization distribution. These alginate oligosaccharides can increase butyrate production by intestinal flora and exert a laxative effect. The alginate oligosaccharide and its preparation method provided by this invention directly use brown algae as raw material, overcoming the drawbacks of traditional methods that first prepare alginate and then hydrolyze it to prepare alginate oligosaccharides, greatly shortening the process steps and improving production efficiency. The alginate oligosaccharides provided by this invention have high purity and broad application potential in the preparation of intestinal health drugs, health products, or dietary supplements.

The application discloses a pterosin sesquiterpenoid compound and a preparation method and application thereof, belongs to the technical field of biological medicines, aims at the problems of a research blank of pterosin sesquiterpenoid compounds in Anemone raddeana and a lack of structure-confirmed anti-inflammatory active monomers, and provides a pterosin sesquiterpenoid compound with a structural formula as shown in the following.The compound preparation needs to first crush dried whole grass of Anemone raddeana, extract by heating and refluxing with an organic solution, concentrate under reduced pressure to obtain total extract; then, the extract is extracted by petroleum ether, ethyl acetate and n-butanol step by step, the ethyl acetate part extract is enriched, and the high-purity product is prepared through multi-step purification of a silica gel column, a C-18 reverse phase column, a gel column and semi-preparative liquid chromatography.In addition, the compound can dose-dependently inhibit the NO release of LPS-induced macrophages, and can be used for preparing anti-inflammatory drugs for treating or preventing inflammatory diseases related to excessive production of nitric oxide, fills the research blank, and provides a high-quality candidate component for anti-inflammatory drug research and development.

The present application relates to a kind of traditional Chinese medicine composition for treating acute exacerbation of chronic bronchitis, the traditional Chinese medicine composition is made of the following weight parts of raw medicinal materials: 10-14 parts of pinellia ternata, 7-11 parts of apricot kernel, 7-11 parts of persicae semen, 7-11 parts of dried tangerine or orange peel, 10-14 parts of radix codonopsis, 13-17 parts of oyster shell, 13-17 parts of concha mactrae, 13-17 parts of ophiopogon japonicus, 7-11 parts of radix clematidis, 1-5 parts of soap plant thorn.The present application is mainly used for treating syndrome of phlegm-dampness accumulating in lung;Effect: dry dampness and resolve phlegm, regulate qi and relieve cough;The monarch drug pinellia ternata in the present application is pungent, flat, warm and dry, and is good at dry dampness and resolve phlegm, and can descend adverse qi and relieve panting.Peach kernel and apricot kernel are used as ministers, which is a wonderful use of qi-blood confrontation: peach kernel enters blood and regulates qi, and apricot kernel enters qi and regulates blood, and the two are complementary, helping pinellia ternata to rotate qi and restore ascending and descending. The use of auxiliary drugs has three meanings: one is to attack evil, radix clematidis can pass through twelve meridians and remove phlegm, soap plant thorn is sharp and can break and soften, and is good at attacking stubborn phlegm. The combination of various drugs can attack and tonify, and is suitable for moistening dryness, and can achieve the effect of dry dampness and resolve phlegm, regulate qi and relieve cough.

The application discloses application of a reagent for detecting AHSP protein in preparation of a product for diagnosing prostate cancer, and relates to the technical field of biological medicine; through proteomic analysis, ELISA test on urine protein of prostate cancer patients, clear cell renal cell carcinoma patients and normal healthy men, and immunohistochemical analysis on file wax blocks of the prostate cancer patients, normal prostate tissues around the cancer, prostate tissues of prostatic hyperplasia and clear cell renal cell carcinoma tissues, it is found that the AHSP protein has a certain relationship with the occurrence and development of prostate cancer, and can be used for assisting diagnosis of the prostate cancer; and in urine detection, AHSP has higher sensitivity than PSA, and when PSA is negative or serum PSA is low, AHSP can form complementation with ASHP, thereby helping to improve the diagnosis rate and non-invasive screening ability; through research on the relationship between the AHSP protein and the prostate cancer, the diagnosis rate of patients can be improved, non-invasive reexamination after treatment is facilitated, drug use is guided, and the survival rate is improved.

The application discloses a composition and a preparation method of a ripretinib cream, and the composition comprises: an active ingredient of ripretinib or a pharmaceutically acceptable salt thereof and excipients, wherein the excipients are composed of an oily base, a humectant, an emulsifier, water, a thickening agent, a preservative and a chelating agent, etc. The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM . The ripretinib cream composition disclosed by the application has the advantages of simpler preparation process, fewer excipients, smaller liquid drop particle size of the produced cream, no precipitation of the raw material drug in the use process, and equivalent clinical curative effect to the original Opzelura TM .

The present application relates to the technical field of peritoneal dialysis, in particular to a multi-bag independent control and intelligent circulation system of peritoneal dialysis equipment. The present application determines the correction residual amount based on the basic backflow residual amount and the basic perfusion residual amount adjusted by the flushing effect of the backflow of waste liquid, and the weight change of each drug liquid bag before and after dialysis circulation and the theoretical ultrafiltration amount. The characteristic correction residual amount is determined based on the state parameter difference of each drug liquid bag dialysis cycle and several dialysis cycles before it. The target flushing amount after each drug liquid bag dialysis cycle is determined based on the characteristic correction residual amount and the concentration gradient difference of the adjacent two circulation drug liquids, and the next drug liquid bag output target flushing amount is controlled to flush the pipeline with the drug liquid, and the generated flushing waste liquid is guided to the previous drug liquid bag to start the next drug liquid bag dialysis cycle. The present application realizes dynamic and accurate quantification of pipeline residual, combines physical correction and personalized habit calibration, and improves the pipeline flushing effect.

This utility model discloses a nursing medication preparation teaching workbench, belonging to the field of teaching equipment technology. It aims to solve the technical problems of high light leakage risk and insufficient light-blocking effect of traditional light-blocking measures. The workbench includes a table body with lifting mechanisms arranged on both sides inside. A teaching mechanism is connected to the lifting mechanisms and is located in the middle of the table body. The teaching mechanism includes an outer frame, inside which is an inner frame. A cavity is formed between the inner and outer frames, and sliding rails are arranged on both sides inside the cavity. This utility model, through the design of a top plate and a light-blocking curtain structure, allows the top plate, along with the light-blocking curtain mounted on its lower surface, to extend from the cavity when the outer frame is raised from inside the table body, forming a dark space. This space reduces external light, facilitating students' medication preparation operations with photosensitive drugs and reducing the risk of photolysis reactions caused by light exposure.

The application belongs to the technical field of biological medicine, and particularly relates to a freeze-dried preparation based on synergistic effect of trehalose and arginine for optimizing the performance of omalizumab reconstitution and a preparation method thereof. The preparation method comprises the following steps: preparing a histidine-hydrochloric acid buffer, dissolving omalizumab, trehalose, arginine and polysorbate 20 in the histidine-hydrochloric acid buffer to prepare a solution preparation; and freeze-drying the solution preparation to obtain the freeze-dried preparation; wherein the molar concentration ratio of trehalose to arginine in the solution preparation is 10-90:15-55. The freeze-dried preparation obtained by using the preparation method has a fast reconstitution speed and a fast bubble disappearance speed during reconstitution, can save time, meets the clinical emergency drug demand, and is more convenient to use.

Provided in the present invention are a compound, a preparation method therefor and the use thereof. The compound has a structure shown as formula (A).wherein X represents an acid, and n is a number from 0.1 to 3. The compound has good biological activity and solubility, and has outstanding potential to be manufactured as a drug.

The application discloses a microneedle, a microneedle patch and a preparation method and application thereof. The microneedle comprises drug-loaded microspheres and a matrix, the drug-loaded microspheres are distributed in the matrix, and the matrix comprises a matrix material and a thickening agent; wherein the matrix material comprises a beta-cyclodextrin derivative. The microneedle patch comprises the microneedle and a substrate, and the microneedle is distributed on the surface of the substrate. The microneedle has high mechanical strength and long-term stability, and the obtained microneedle patch can be applied to the fields of medicine and medical aesthetics.

A bispecific antibody, a drug conjugate thereof, and uses thereof are provided. The bispecific antibody comprises an EGFR binding domain and a HER3 binding domain. The bispecific antibody and the drug conjugate thereof provided by the invention have good endocytosis effect, proliferation inhibition activity, tumor growth inhibition activity and good in-vivo safety.

This invention discloses a GABA-loaded hydrogel microneedle, its preparation method, and its application, belonging to the field of biomedical materials technology. This drug-loading system uses polypyrrole-grafted gelatin (PPy) as the loading medium. ‑ Using gelatin (GelMA), carboxymethyl chitosan, and methacrylate gelatin (GelMA) as a matrix, a three-dimensional network hydrogel (PPG@Gel) is formed through cross-linking with aldehyde-modified polyethylene glycol (PEG-CHO) and loaded with γ-aminobutyric acid (GABA). The preparation process includes GelMA modification, PPy-GelMA graft polymerization, PEG-CHO cross-linking agent synthesis, and mixing of each component with GABA to form a precursor hydrogel (PPG@Gel), which can ultimately be prepared as a microneedle patch (PPG@MN). This invention utilizes the excellent biocompatibility and permeability of hydrogels to achieve precise local delivery of GABA to lesions in inflammatory skin diseases. GABA can target and inhibit abnormal inflammatory responses, regulate epidermal cell function, and repair the skin barrier, while avoiding the adverse reactions and cost drawbacks of existing treatments. The hydrogel raw materials are readily available and highly safe, allowing for continuous drug delivery to improve patient compliance. It is suitable for the treatment of various inflammatory skin diseases such as psoriasis and eczema, and has significant clinical application value.

The present application relates to a kind of donkey milk source anti-inflammatory peptides and its preparation and application, by preparing and screening from donkey milk the amino acid sequence of high anti-inflammatory activity polypeptide GWNIPIGT or EAGW, with excellent thermal stability and digestion stability, can concentration-dependent inhibit LPS-induced NO release, significantly reduce proinflammatory factor TNF-α level, increase anti-inflammatory factor IL-10 level, and inhibit iNOS activity and COX-2, while with good antioxidant activity, the donkey milk source anti-inflammatory peptide of the present application has excellent safety, stability, can multi-target point regulation inflammatory response, not only provides new candidate molecule for the development of functional food and anti-inflammatory drugs, also lays scientific foundation for the high-value utilization of donkey milk.

The present application belongs to the field of medical material surface functionalization, and particularly relates to a kind of nano drug-loaded hydrogel catheter coating and its preparation method and application.The present application utilizes PLGA to load antibiotic amikacin sulfate AMK or antibacterial peptide FK13-a1, synthesizes nanoparticle NP-AM and nanoparticle NP-FK, prepares NP-AM / FK@OMV nanoparticle complex with EcN OMV as carrier, then adds poloxamer-hyaluronic acid composite hydrogel to obtain NP-AM / FK@OMV-P / H nano drug-loaded hydrogel, and forms coating after coating and drying.The nano drug-loaded hydrogel coating provided by the present application has the characteristics of enzyme response, antibacterial, prevention of biofilm formation and low toxicity, has great application potential in inhibiting medical catheter surface biofilm, and has important significance for preventing and treating CAUTI, prolonging the use time of indwelling catheter, and reducing the discomfort of patients caused by frequent replacement of catheter.

Disclosed are an antibody capable of binding to thymic stromal lymphopoietin and the use thereof. Disclosed are an anti-TSLP antibody, comprising a murine antibody, chimeric antibody and humanized antibody of the light chain and heavy chain variable regions of the anti-TSLP antibody and antigen-binding fragments thereof, or a pharmaceutically acceptable salt or solvent compound thereof, and the use thereof as a drug for treating asthma, especially the use thereof in the preparation of a drug for treating TSLP-positive diseases or conditions.

The utility model relates to a kind of drug core welding wire disc automatic labeling machine, belong to drug core welding wire processing device technical field.Roller conveyor is provided in the lower part of rack, and label-removing platform is provided above roller conveyor, and label-removing platform is provided with label-removing machine, laser scanning sensor for detecting label-removing process is provided at the front end of label-removing machine, and the label-removing machine includes turn-back platform;Vacuum generator is provided at the front end of turn-back platform, and vacuum generator upper end is connected with cylinder power output end, and roller conveyor is matched with mirror reflection photoelectric sensor, and laser scanning sensor and mirror reflection photoelectric sensor are connected with controller input end, and controller output end is connected with label-removing machine switch, vacuum generator switch, cylinder's inflation pump switch and roller conveyor switch.The device provided in the utility model realizes the automatic labeling of welding wire disc, solves the problems of missing, wrong and repeated labeling in traditional manual labeling, and the labeling position is accurate and controllable with high efficiency.

The application belongs to the technical field of wound dressings, and discloses a water-based gel dressing with antibacterial and scar prevention effects and a preparation method, wherein 3-fluoro-4-carboxyphenylboronic acid is introduced to graft chitooligosaccharide, a large number of catechol structures in tannic acid solution are combined with the phenylboronic acid bond to form a dynamic boron ester bond, and a network gel structure is formed by responding to the supermolecular forces such as hydrogen bonds, wherein the boron ester bond can be broken in response to the high ROS level of the wound microenvironment and the acidic environment caused by bacterial infection, so as to efficiently release celecoxib, a selective non-steroidal anti-inflammatory drug of cyclooxygenase-2, and the liposome of verteporfin is limited in volume and stays in the dressing for a longer time, so that the sustained and stable release can be maintained in the whole wound healing process, thereby achieving the effects of on-demand inflammation regulation and long-acting mechanical response regulation.

This invention discloses a method for screening pancreatic lipase inhibitory peptides based on machine learning, relating to the fields of bioinformatics and food science. The method includes the following steps: dataset construction and three-dimensional peptide structure characterization, statistical-based feature screening, outlier removal based on a dual-model consensus mechanism, feature recursive elimination and physicochemical significance optimization, data augmentation based on Gaussian noise injection, and final prediction model construction. This invention effectively solves the problems of insufficient feature representation, high noise interference, and weak model generalization ability in existing screening methods through multi-dimensional feature characterization, rigorous outlier cleaning, and data augmentation strategies for small samples. It can quickly and accurately screen highly active pancreatic lipase inhibitory peptides from massive peptide sequences, providing an efficient computational tool for the development of functional foods and lipid-lowering drugs.