1294 results about "Drug" patented technology

The invention provides glycyrrhizic acid / glycyrrhetinic acid-triethanolamine composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of preparation of biological medicine carriers and composite materials. According to the invention, glycyrrhizic acid or glycyrrhetinic acid is taken as a raw material, triethanolamine is taken as a cross-linking regulating agent, and the composite hydrogel with stable mechanical properties, high drug loading efficiency and anti-inflammatory synergistic activity is prepared through a mild physical and chemical cross-linking reaction; the preparation process of the composite hydrogel does not need a toxic cross-linking agent, the reaction condition is mild, the raw materials are cheap and easy to obtain, and large-scale production can be realized; the composite hydrogel presents a multi-group ionic bond cross-linked structure, can be used as a carrier of a pH responsive drug, and has good practicability.

The invention relates to the technical field of micro-nano robots, and provides a motion control method and system for a magnetic control micro-nano robot carrying medicine in a simulation environment, and the method comprises the steps: obtaining a motion image of a magnetic control silicon dioxide-based micro-nano robot cluster in the simulation environment in real time; according to a preset transportation task, the current state of the micro-nano robot cluster is judged; based on the current state of the micro-nano robot cluster, establishing a magnetic field generated by the micro-nano robot cluster and the three-dimensional Helmholtz coil, a fluid resistance field of a simulation environment and a dynamic model of a simulation environment channel boundary condition; and based on the motion image acquired in real time, using a deep learning model to identify real-time pose information of the micro-nano robot cluster and the simulated environment channel boundary information, and using a path planning algorithm to perform trajectory planning according to the real-time pose information and the simulated environment channel boundary information. And the magnetic field is adjusted to control the movement of the micro-nano robot cluster.

The invention relates to a double-framework self-developing embolism system based on iodine modified PNIPAM gel and cross-linked albumin microspheres, which simulates a brick wall-concrete effect through a microsphere-gel composite structure and synergistically improves the embolism strength. A novel TACE treatment system is designed and constructed, multiple effects of tracing, embolism, hypoxia enhanced chemotherapy and tumor microenvironment improvement are achieved through the self-developing temperature-sensitive gel-drug carrying microspheres, and the anti-tumor effect is cooperatively improved.

The invention relates to the technical field of medical instruments, in particular to a microneedle array device for skin. Comprising a shell, and the array assembly comprises a microneedle assembly and a driving assembly used for driving the microneedle assembly; the guide assembly is used for guiding the movement of the microneedle array; the detection assembly is provided with a high-frequency ultrasonic sensor and used for detecting the skin thickness. The data acquisition module acquires thickness information, and the data analysis module determines the target penetration depth of the microneedle and generates a control instruction according to the thickness information. And the microneedle driving module drives the microneedle to act after receiving the instruction. The penetration feedback module detects the actual penetration depth in real time and judges whether the actual penetration depth reaches the standard or not. And when the penetration is unqualified, the strategy regulation and control unit adjusts the driving strategy according to the deviation direction between the actual depth and the target depth, so that accurate and controllable micro-needle penetration is realized. The problems that medicine liquid cannot be effectively injected according to different skin thicknesses, and whether potential safety hazards exist in the actual penetration depth of the skin or not cannot be found in time are solved.

The invention is applicable to the technical field of biomedicine, and provides dipeptide-photosensitizer molecule co-assembled nanoparticles as well as a preparation method and application thereof. According to the invention, cationic diphenylalanine (CDP) and a biological cross-linking agent genipin are self-assembled to form a dipeptide carrier, and then the dipeptide carrier and a photosensitizer molecule chlorin e6 (Ce6) are co-assembled, so that nanoparticles with controllable size, controllable drug loading capacity and good biocompatibility are successfully prepared. The preparation method is simple and easy to implement, effectively solves the key problems that the traditional photosensitizer molecule Ce6 is poor in biocompatibility and easy to gather, not only can efficiently deliver Ce6, but also obviously improves the application safety and biocompatibility of Ce6. The Ce6 is almost free of dark toxicity under a dark condition, can play a strong photodynamic killing role under illumination, and greatly improves the possibility and application potential of the Ce6 in tumor photodynamic therapy by virtue of the flexible regulation and control advantages of the size and the drug loading capacity.

The invention discloses a colchicine external preparation with high intradermal residual quantity and percutaneous transmittance as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The invention provides a colchicine external preparation with high intradermal residue and transdermal transmittance. The colchicine external preparation comprises: a) colchicine or a pharmaceutically acceptable salt thereof; b) a penetration enhancer; c) pharmaceutically acceptable excipients and / or excipients; the penetration enhancer is at least one of polyglycerol oleate or isosorbide dimethyl ether. The drug loading capacity and the percutaneous transmittance of the colchicine external preparation disclosed by the invention are remarkably improved. When polyglycerol oleate is selected as a penetration enhancer to prepare colchicine gel, the intradermal retention volume can reach 358.08 micrograms within 20 hours. When isosorbide monomethyl ether is selected as a penetration enhancer to prepare ethosome gel, the accumulated penetration amount can reach 106.87 mu g / cm < 2 >, and the intradermal residual amount can reach 90.58 mu g or above.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving cognition, emotion, memory and depression states and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: radix scutellariae, rhizoma coptidis, radix puerariae, rhizoma anemarrhenae, bitter gourd, rhizoma zingiberis, stiff silkworm, American ginseng and radix notoginseng. Wherein the radix scutellariae and the rhizoma coptidis are monarch drugs and mainly attack the core pathogenesis; the radix puerariae, the rhizoma anemarrhenae and the pseudo-ginseng serve as ministerial drugs, assist monarch drugs and treat secondary pathogenesis; bitter gourd, rhizoma zingiberis, stiff silkworm and American ginseng are used as adjuvant drugs to regulate drug properties and treat and treat both symptoms and root causes; and radix puerariae and pseudo-ginseng are used as conductant drugs for guiding channels or harmonizing the drugs. The traditional Chinese medicine composition disclosed by the invention can be used for preventing and treating cognitive disorder, mood disorder and depressive state caused by metabolic disorder. The traditional Chinese medicine composition is small in side effect, high in individuation and suitable for being taken for a long time, and has an obvious treatment effect.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for preventing and treating sepsis based on intestinal treatment and gasification regulation and a preparation method and application of the traditional Chinese medicine compound preparation. The composition is prepared from the following medicinal materials in parts by weight: 3 to 10 parts of rheum officinale, 5 to 10 parts of fructus aurantii, 5 to 10 parts of radix aucklandiae, 10 to 15 parts of fructus gardeniae, 10 to 15 parts of dandelion, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of herba artemisiae scopariae, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of radix paeoniae rubra, 10 to 15 parts of radix salviae miltiorrhizae, 15 to 20 parts of astragalus membranaceus, 10 to 15 parts of rhizoma anemarrhenae, 10 to 15 parts of fructus cannabis, 10 to 15 parts of semen pruni and 3 to 6 parts of raw liquorice. The traditional Chinese medicine compound provided by the invention considers the treatment rules of relaxing bowels, purging heat, promoting qi circulation, removing stagnation, detoxifying, dispersing blood stasis, reinforcing qi, nourishing yin and the like, and also considers the effects of relaxing bowels, regulating qi and supporting healthy qi, various diseases of sepsis patients can be remarkably improved through the synergistic effect of the medicines in the formula, and the traditional Chinese medicine compound especially has an obvious curative effect on gastrointestinal dysfunction. A novel traditional Chinese medicine treatment thought is provided for clinical treatment of sepsis diseases.

A traditional Chinese medicine composition for treating pulmonary nodules, wherein the composition is prepared from the following traditional Chinese medicines in parts by weight: a principle drug selected from one or more of 10-45 parts of raw Astragali radix, 10-25 parts of Sargassum, and 10-25 parts of Arisaematis rhizoma preparatum; a minister drug selected from one or more of 10-25 parts of Fritillariae thunbergii bulbus, 10-25 parts of Forsythiae fructus, 10-25 parts of stir-fried Atractylodis macrocephalae rhizoma, 1T0 part of Hirudo, 10-25 parts of Dioscoreae nipponicae rhizoma, 10-35 parts of Adenophorae radix, 10-35 parts of honey-processed Mori cortex, 10-25 parts of Perillae fructus, 10-25 parts of Peucedani radix, 10-35 parts of Phragmitis rhizome, 10-45 parts of raw Coicis semen, 5-25 parts of vinegar-processed Cyperi rhizoma, 10-25 parts of Aurantii fructus, 10-25 parts of Paeoniae radix alba, 10-35 parts of Scutellariae barbatae herba, 10-35 parts of Herba duchesneae indicae, 10-35 parts of Salviae chinensis herba, 5-20 parts of Menispermi rhizoma, 5-20 parts of Momordicae semen, 10-25 parts of Curcumae rhizoma, and 5-20 parts of Gleditsiae spina; an assistant drug selected from one or more of 5-25 parts of vinegar-processed Bupleuri radix, 5-25 parts of Citri reticulatae pericarpium, 10-25 parts of Perillae fructus, 2-12 parts of processed Ephedrae herba, 10-25 parts of Cynanchi stauntonii rhizoma et radix, 5-20 parts of Typhonii rhizoma, 2-12 parts of Zingiberis rhizoma, 10-35 parts of Morindae officinalis radix, 10-35 parts of Scutellariae barbatae herba, 10-45 parts of Radix aconiti lateralis praeparata nigra, and 10-25 parts of Typhonii rhizoma praeparata; and an envoy drug selected from one or more of 5-20 parts of Fagopyri dibotryis rhizoma, 10-25 parts of Platycodonis radix, 10-25 parts of Paeoniae radix alba, and 5-25 parts of Glycyrrhizae radix et rhizoma praeparata cum melle.

The embodiment of the invention provides a self-powered microneedle patch for repairing hypertrophic scars as well as a preparation method and application of the self-powered microneedle patch. The self-powered microneedle patch comprises: a friction nano-generator for generating a current; the conductive drug-loaded microneedle patch is connected with the friction nano-generator, and the friction nano-generator is connected with the conductive drug-loaded microneedle patch; the conductive drug-loaded microneedle patch comprises a conductive microneedle patch body and a crosslinked gelatin-crosslinked hyaluronic acid microneedle bearing Sb4. The surface of the conductive micro-needle patch is provided with a metal coating, and the conductive micro-needle patch is used for mediating current generated by the friction nano-generator and applying percutaneous electrical stimulation; the cross-linked gelatin-cross-linked hyaluronic acid microneedle is coated at the tip of the conductive microneedle patch. According to the self-powered microneedle patch provided by the embodiment of the invention, myofibroblasts of hypertrophic scars are transdifferentiated into adipocytes by providing percutaneous electrochemical stimulation, inflammatory factor release is inhibited, and a tissue microenvironment is remodeled, so that the hypertrophic scars are reversed, and skin repair and tissue regeneration are realized.

The invention discloses a drug use knowledge intelligent question answering system and method combined with a knowledge graph, belongs to the technical field of drug use management, and solves the problems that only single-path matching is supported and complex multi-hop query cannot be processed when an answer is determined by adopting similarity matching between a regularized question and a template library in an existing method; in order to solve the problem that personalized accurate recommendation cannot be realized according to actual conditions of different patients, the method comprises the steps of performing multi-modal analysis on drug use demands of the patients, generating a structured demand query graph, pre-constructing a drug use question and answer model based on a dynamic knowledge graph, and performing multi-dimensional parallel evaluation on a candidate answer set. According to the method, multi-modal analysis is carried out on the medication demand of the patient, and multi-dimensional parallel evaluation is carried out on the candidate answer set, so that complex multi-hop query can be processed, diversified demands of the patient can be met more comprehensively, the personalized degree and practicability of the answers can be improved, and personalized accurate recommendation can be realized according to actual conditions of different patients.

The invention relates to the technical field of functional probiotic screening and application, and particularly provides a bifidobacterium animalis subsp. Lactis (Bifidobacterium animalis subsp. Lactis) capable of relieving liver injury and regulating glycolipid metabolism and application of the bifidobacterium animalis subsp. Lactis. The preservation number of the bifidobacterium animalis subsp. Lactis is CGMCC No.31656, and the bifidobacterium animalis subsp. Lactis can effectively reduce blood sugar and blood fat of diabetic mice and relieve insulin resistance and has the capacity of relieving diabetic cardiomyopathy. The strain has wide application prospects in preparation of drugs for treating diabetes mellitus, liver injury and glycolipid metabolism.

This invention discloses a protein-polysaccharide ternary nanoparticle loaded with cordycepin, its preparation method, and its applications. The invention employs a layer-by-layer self-assembly method to modify the surface of zein nanoparticles. Since zein has a positive surface charge, the first layer modification uses the anionic polysaccharide sodium alginate for electrostatic bonding, and the second layer modification uses the cationic polysaccharide chitosan, constructing positively charged ternary composite nanoparticles. These nanoparticles have small particle size, high encapsulation efficiency, high drug loading capacity, and a sustained-release effect, significantly reducing cytotoxicity and significantly improving the therapeutic effect on osteoarthritis. This invention develops a novel cordycepin formulation, overcoming the limitations of cordycepin's clinical use.

The invention discloses a gel microneedle loaded with silver nanoparticles and a preparation method and application thereof.The extract nano-silver (AB-AgNPs) is prepared through a green synthesis strategy, a drug-loaded microneedle system is constructed based on carboxymethyl chitosan-vanillic aldehyde-polyvinyl alcohol (CMCS-Va-PVA) composite gel, the AB-AgNPs prepared through the technology are uniform in particle size and stable in dispersion, and the drug-loaded microneedle has the advantages that the drug-loaded microneedle is good in drug-loaded performance and good in drug-loaded performance; the crystal has a typical face-centered cubic crystal structure and metal state Ag0 characteristics; the gel microneedle has good mechanical strength and forming effect, the AB-AgNPs and the gel matrix are stably combined through hydrogen bonds, the chemical properties are kept unchanged, and the system has broad-spectrum efficient bacteriostatic activity and biocompatibility; an in-vitro experiment proves that the green synthesized gel microneedle loaded with the silver nanoparticles has a remarkable capability of promoting the healing of L929 cell tissues; a rat wound experiment proves that the gel microneedle can regulate and control an inflammatory factor network and promote cell migration and tissue regeneration, healing of common and infected wounds is remarkably accelerated, and the wound residue ratio in 9 days is as low as 2.7% and 10.9% respectively.

The application provides a preparation method and application of oat active peptides for promoting GLP-1 secretion, wherein the oat active peptides contain any one or more of peptide segments NDQRGEII, KQGDVIALPA, PFVQQQQ and PSEQYQPYPEQQEPFVQ. The preparation method of the oat active peptides comprises enzymolysis, chemical synthesis or genetic engineering. The oat active peptides can significantly promote the secretion of GLP-1 by intestinal endocrine cells, and have the advantages of safe and non-toxic side effects, tolerance to gastrointestinal digestive enzyme hydrolysis and easy absorption. The application has simple operation, low requirement for equipment, is suitable for industrial large-scale production, and can be used for the development of new drugs for controlling blood sugar or food for assisting in controlling blood sugar, drugs for controlling body weight or food for assisting in controlling body weight and the like.

The invention discloses a joint detection kit for genetic risk genes and medication genes of Alzheimer's disease and a multivariable risk assessment model. The kit comprises a detection reagent for detecting 25 mutation sites of 15 genes, wherein the 25 mutation sites of the 15 genes comprise 17 mutation sites of 10 risk genes and 10 mutation sites of 6 medication genes. Amplification primer pairs and single-base extension primers of each site are designed for 25 mutation sites of 15 genes, multiple PCR amplification and single-base extension reactions are carried out, and the genotype of each site of a product is analyzed by using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. A multivariable risk assessment model for the Alzheimer's disease is constructed by taking a genetic risk score GRS, age, gender and plasma p-tau217 concentration of a risk gene mutation site as markers, one-stop detection of'early screening and medication guidance 'can be realized in combination with a medication gene detection result, and the application prospect and demand are broad.

The invention relates to the technical field of biology, and provides a genetic marker for children nephrotic syndrome genetic risk assessment. The invention relates to genetic detection and application of hormone sensitive nephrotic syndrome (pSSNS) of children. Nine risk sites, including new sites of 1q23.1, 1p36.13, 5p13.2, 10q21.3, 10q24.1 and the like, highly related to diseases are found by integrating whole genome association research (GWAS) data, combining Meta analysis and a conjugate false discovery rate (conjFDR) method and taking genetic information of IgA nephropathy as assistance. Research results show that genes near the loci have differential expression in pSSNS and IgAN patients, which prompts that the genes play an important role in the occurrence and development of diseases. The invention provides a molecular detection method based on the risk site, which can be used for risk assessment, auxiliary diagnosis and prognosis prediction of children's nephropathy. Meanwhile, the invention provides potential application values of the loci and related genes thereof in individualized medication and targeted therapy.

According to the oseltamivir phosphate granules and the preparation method thereof, the granules are prepared by mixing the medicine-containing granules, the blank granules and the pharmaceutically acceptable auxiliary materials, and by selecting the specific auxiliary materials and the proportion of the auxiliary materials, the prepared granules maintain a high dissolution speed and achieve a good taste masking effect; according to the present invention, the traditional Chinese medicine composition has advantages of good taste, high content uniformity, high dissolution speed, good fluidity, low related substance content, good stability and the like, can meet different administration dosage requirements, and is suitable for children administration, and the pharmaceutical composition can be used for children, and can be used for preparing drugs for children, such that the pharmaceutical composition has characteristics of good taste, high content uniformity, high dissolution speed, good fluidity, low related substance content, and the like.

The invention relates to the technical field of medical nano-materials, and discloses a pH-responsive drug self-delivery nano-system and a preparation method and application thereof.The preparation method comprises the steps that 1, CMNPs is prepared, specifically, through an amidation reaction, the CMNPs are prepared from methotrexate and cis-aconitic anhydride; step 2, synthesizing DSPE-PEG-T12: synthesizing the DSPE-PEG-T12 by virtue of a nucleophilic addition reaction; step 3, preparing a T12 peptide modified erythrocyte membrane; and step 4, preparing T12-RBCM (at) CMNPs: modifying the T12 peptide of the targeted tumor cell transferrin receptor on an erythrocyte membrane, and coating the CMNPs to construct the nano-acquisition system T12-RBCM (at) CMNPs. According to the nano system T12-RBCM (at) CMNPs obtained by the scheme, the tumor cell uptake efficiency can be remarkably improved, cell apoptosis is induced, and proliferation is inhibited; the long-acting circulation and tumor targeting capability is realized, the tumor growth can be effectively inhibited, and the biological safety is good.

The invention belongs to the technical field of pharmaceutical preparation equipment, and particularly discloses a mixing and blending device for preparing an anti-tumor medicament. The bottom of the cylindrical tank body is funnel-shaped and is connected with an outlet of a butterfly valve; a top cover is arranged at the top of the tank body and is provided with a main shaft driven by a servo motor, the upper section of the main shaft is provided with a double-end spiral stirring blade, the screw pitch is gradually reduced from top to bottom, and the lower section is fixed with a shearing stirring blade which is provided with a through hole. A plurality of layers of inclined guide plates are arranged on the inner wall of the tank body to form a layered stirring frame which forms a reverse shear flow field with the spiral blades. An interlayer cavity in the side wall of the tank body is connected with a circulating guide pipe to achieve cooling temperature control, a dynamic sealing ring between the main shaft and the top cover conducts self-adaptive sealing, and the top cover is provided with an inert gas connector and a gas outlet. The supporting base is connected with the fixing ring base through the damping spring. Through the synergistic effect of layered reverse shearing, dynamic sealing and a cooling system, the chemical mixing uniformity is remarkably improved, the oxidation and leakage risks are reduced, and meanwhile vibration and operation complexity are reduced.

The invention relates to a method and a system for constructing a traditional Chinese medicine lung cancer prevention and treatment system based on multi-source data fusion, belongs to the technical field of big data, integrates multi-source information such as global evidence-based literature, real world clinical data and expert decision support, constructs an AI-driven three-layer cognitive model, develops a clinical transformation platform, and provides a traditional Chinese medicine lung cancer prevention and treatment system. The method comprises the following steps: screening dominant treatment stages through an intelligent algorithm, optimizing a diagnosis and treatment scheme, establishing a quantitative correlation model of pathogenesis key elements and tumor metabolic activities, further constructing a syndrome-metabolism knowledge graph, forming a syndrome differentiation validity verification mechanism and a prescription linkage database, and finally designing a result transformation engine. New drug research and development and nosocomial preparation conversion are driven through an evidence chain, and evaluation standards are formulated in cooperation with traditional Chinese medicine syndrome improvement and western medicine solid tumor curative effect indexes. According to the method, the bottleneck problems of data splitting, dialectical staticizing and conversion in traditional research are solved, and full-chain innovation from cognitive modeling to clinical landing is achieved.

The invention relates to the technical field of biological scaffolds, in particular to a silk fibroin-based biological 3D intelligent response scaffold and a preparation method and application thereof.The silk fibroin-based biological 3D intelligent response scaffold adopts a three-layer bionic gradient structure of an oriented fiber membrane, a porous sponge layer and an interface layer, simulates natural tissues, and has the advantages that the bionic gradient structure is improved; mechanical guidance, cell inhabitation and biological activity interfaces are provided respectively, and high-quality regeneration of blood vessels, nerves and skin is promoted synergistically. According to the present invention, the pH / enzyme / temperature triple response unit is provided, such that the lesion microenvironment can be perceived, the targeted release can be triggered, the problem of high burst release rate of the traditional physical drug loading can be solved, and the on-demand accurate drug delivery can be achieved. The SF / HPMC gel is adopted for 3D printing, the printing precision is high, and the porosity difference is 1t; the product performance is stable, and the pore structure can be precisely designed and customized according to the regeneration requirements of different tissues (such as blood vessels, nerves and skin).

The invention provides a medicinal and edible tea drink composition for assisting in reducing uric acid and a preparation method thereof, and belongs to the technical field of health-care food. The medicinal and edible tea drink composition for assisting in reducing uric acid comprises corn stigma, chicory, folium mori, fructus gardeniae, radix puerariae, fructus crataegi, semen coicis, poria cocos, rhizoma polygonati, pericarpium citri reticulatae and liquorice root. Cichorium intybus and folium mori are used as monarch drugs and synergistically inhibit the activity of xanthine oxidase; corn stigma and cape jasmine are used as ministerial drugs and have the effects of forcefully inducing diuresis and reducing the blood uric The radix puerariae can improve insulin resistance, the coix seeds and the poria cocos can tonify spleen and excrete dampness, and the rhizoma polygonati can tonify spleen and tonify kidney to treat both symptoms and root causes and serve as Hawthorn, pericarpium citri reticulatae and liquorice are used for regulating the medicine property and neutralizing the bitter taste, so that the consumer experience and compliance are greatly improved. The medicinal and edible tea drink composition achieves the effect of reducing uric acid through a multi-target and multi-path synergistic effect of inhibiting generation, promoting excretion and conditioning root.

The invention provides a drug-loaded sophorolipid microsphere, a preparation method thereof and application of the drug-loaded sophorolipid microsphere in preparation of a bionic cartilage scaffold. The preparation method of the drug-loaded sophorolipid microspheres comprises the following steps: (1) preparing a drug-containing sophorolipid solution; (2) preparing multiple emulsion; and (3) adding a horse radish peroxidase solution into the multiple emulsion for reaction to obtain the drug-loaded sophorolipid microspheres. The bionic cartilage scaffold sequentially comprises a bone layer, a transition layer and a cartilage layer from bottom to top, the bone layer is a cross-linked compound of nano-hydroxyapatite and drug-loaded sophorolipid microspheres; the transition layer is a physical mixture of nano-hydroxyapatite and drug-loaded sophorolipid microspheres; the cartilage layer is drug-loaded sophorolipid microspheres. The drug-loaded sophorolipid microspheres disclosed by the invention have good biocompatibility, excellent biocompatibility and good mechanical properties. The bionic cartilage scaffold utilizes the characteristics of the nHA and the drug-loaded sophorolipid microspheres to form a unique network structure, so that material failure caused by mechanical mismatching is avoided.

The invention relates to an application of a bioactive peptide YPFPGPIH derived from bovine casein in the aspect of anti-inflammation or immunoregulation. The peptide can be combined with TLR2 and TLR4 to inhibit the activation of NF-kappa B and MAPK signal channels, so that the levels of inflammatory factors such as IL-1beta, TNF-alpha and NO are remarkably reduced, the expression of IL-10 is up-regulated, and inflammation balance regulation is realized; the body inflammatory response is improved, and the immune organ injury is recovered. The peptide can be used for preparing anti-inflammatory drugs, immunomodulatory functional foods and nutritional supplements, and has good safety and application prospects.

The invention relates to a nano bismuth agent for preventing and / or treating gastritis infection as well as a preparation method and application thereof, the preparation method comprises the following steps: respectively dissolving soluble bismuth salt and a sulfur-containing compound, mixing, and reacting to obtain the nano bismuth agent after the reaction is finished, the sulfur-containing compound is any one or a combination of at least two of thioamino acid, vitamin B1, thioacetamide, sodium sulfide, sodium thiosulfate, bovine serum albumin, whey protein, ovalbumin or metallothionein. The prepared nano bismuth agent has efficient antibacterial performance, shows an excellent curative effect which is two orders of magnitude higher than that of an existing bismuth complex on clinically separated drug-resistant helicobacter pylori, and does not further induce increase of drug resistance of the helicobacter pylori.

The invention discloses a tumor traditional Chinese medicine intelligent prescription recommendation method and system based on knowledge distillation and reinforcement learning, and the method comprises the steps: building an interpretable prescription recommendation model, inputting the tumor symptom data of a patient into the interpretable prescription recommendation model, and obtaining a traditional Chinese medicine prescription recommendation result; wherein the interpretable prescription recommendation model is obtained through training by adopting a knowledge distillation method and a reinforcement learning method, LoRA fine tuning is performed by utilizing a three-section distillation sample, and the fine-tuned model is subjected to reinforcement tuning by utilizing a direct preference optimization method; the three-stage distillation sample comprises symptom analysis, prescription recommendation and prescription analysis, the method can perform modeling on information such as clinical manifestation and tongue picture of a patient to identify typical syndromes, and explanation and description of monarch, minister, assistant and guide structures, medicine property compatibility logic, treatment rules and basis and the like are performed on the generated prescription.

The utility model relates to the field of grain processing, and discloses a grain rolling work fixture, which comprises two clamping rollers, a plurality of clamping rollers and a plurality of clamping rollers, the number of the adjusting mechanisms is two, the two adjusting mechanisms are arranged at the two ends of the clamping rollers correspondingly, and the adjusting rollers are used for adjusting the distance between the two clamping rollers. The clamping roller comprises a first supporting plate and a second supporting plate, the first supporting plate and the second supporting plate are arranged at the two ends of the clamping roller respectively, a rotating plate is installed on the first supporting plate, and the rotating plate is rotationally connected with the first supporting plate through a rotating block. According to the device, the adjusting mechanisms are arranged at the two ends of the clamping rollers respectively, the overall distance between the two clamping rollers can be adjusted, the distance between the same ends of the clamping rollers can also be adjusted, the two clamping rollers can be in the state that one end is narrow and the other end is wide so as to adapt to grains with different diameters at the two ends, the clamping rollers can be tightly attached to the grains, and therefore the grain conveying efficiency is improved. And the application range of the clamp is widened.

The invention provides an automatic anesthetic administration method, device and system. The method comprises the following steps: acquiring clinical information of a patient; inputting the clinical information of the patient into the trained anesthetic administration model, and outputting an initial anesthetic administration amount by the anesthetic administration model according to the clinical information of the patient; the anesthetic administration model receives intraoperative parameters of the patient during injection according to the initial anesthetic administration amount; the anesthetic administration model outputs the adjusted anesthetic administration amount according to the intraoperative parameters; and the anesthetic administration model repeatedly receives the intraoperative parameters of the patient for injection according to the adjusted anesthetic administration amount, and outputs the adjusted anesthetic administration amount according to the intraoperative parameters until the operation is finished. In this way, individualized medication can be accurately achieved, and anesthesia management differences caused by individualized differences of patients are avoided.

The invention belongs to the field of pharmaceutical preparations. The invention relates to a novel dosage form of an isavuconazole sulfate freeze-dried tablet, and a prescription and a process for preparing the isavuconazole sulfate freeze-dried tablet by adopting a freeze-drying method. The isavuconazole sulfate freeze-dried tablet is prepared from isavuconazole sulfate serving as a main drug and pharmaceutic adjuvants. Water is not needed during taking, and the tablet can be rapidly disintegrated after being put in the mouth and is suitable for patients with dysphagia such as old people and children; the production process of the isavuconazole sulfate freeze-dried orally disintegrating tablet is simple in technology, easy to control and suitable for industrial production.