3310 results about "Drug" patented technology

The invention discloses a nitrogen-containing bridged ring compound serving as a GLP-1 receptor agonist as well as a preparation method and application of the nitrogen-containing bridged ring compound. Specifically, the invention discloses a compound as shown in a formula (I), and application of the compound in preparation of drugs for treating or preventing GLP-1 mediated diseases. # imgabs0 #

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The present disclosure provides compounds according to Formulae I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, XIII, and XIV for use as a component in a lipid nanoparticle composition for the delivery of biological and / or therapeutic agents. The present disclosure also provides novel, stable lipid nanoparticle compositions comprising one or more biological and / or therapeutic agents, as well as methods of making and delivering lipid nanoparticle compositions.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The invention discloses development, preparation and application of a carbapenemase immunochromatography kit, and belongs to the technical field of biological medicines. According to comparison of amino acid sequences of five common carbapenemase variants of KPC, IMP, NDM, VIM and OXA48 types, the immunogen is prepared from conserved epitope sequences obtained respectively. A mouse is immunized, and a specific antibody pair which is strong in affinity and can be combined with multiple variants is obtained through multi-platform screening. On the basis, the carbapenemase quintuplet detection kit is developed by utilizing an immunochromatography method, has the advantages of high sensitivity, good specificity, capability of covering various drug-resistant variants, capability of detecting multiple targets at one time and rapidness and convenience in detection, and provides important help for clinical auxiliary diagnosis and medication guidance.

A method of treating anxiety disorders specifically not associated with causes such as a life-threatening serious somatic illness, by administering a psychedelic to an individual, and treating anxiety and specifically causing reductions in the rating scale score measures of anxiety (STAI global or state or trait anxiety) and / or measures of depression (HDRS or BDI scores) and / or measures of general psychological distress (SCL-90 ratings) in the patient for several weeks beyond administration of the psychedelic. A method of treating anxiety, by administering a psychedelic (preferably LSD) to an individual having anxiety not associated with causes such as a life-threatening serious somatic illness, and inducing positive acute drug effects and positive long-term therapeutic effects in the individual.

The invention discloses a drug use dynamic risk assessment method and system for an elderly patient, and relates to the technical field of drug use risk assessment, and the method comprises the steps: collecting static factor data and dynamic factor data of the elderly patient, carrying out the preprocessing of the collected static factor data and dynamic factor data, and generating a feature vector for risk assessment; calculating a comprehensive risk score through a preset evaluation rule based on the feature vector; the comprehensive risk score is compared with a preset risk grading threshold value, the medication compliance risk grade of the elderly patient is determined, and the system comprises a data collection module, a preprocessing module, a risk assessment module and a grading module. The comprehensiveness and timeliness of medication compliance risk assessment of elderly patients are improved, and technical support is provided for medication intervention.

Systems and methods for predicting and managing seizures in an individual are disclosed. In one aspect, a method for predicting and managing seizures in an individual. In another aspect, a system comprising an implanted device configured to capture at least one measurement of an impedance of brain tissue of an individual and a computing device configured to. in response to a prediction that the individual is likely to experience a seizure, initiate a remedial action that comprises at least one of alerting the individual or another user that the individual is likely to experience the seizure, applying an electrical stimulus to the brain tissue of the individual to reduce a likelihood of the seizure occurring or to reduce a severity of the seizure, or delivering a drug to the brain tissue of the individual to reduce a likelihood of the seizure occurring or to reduce a severity of the seizure.

The embodiment of the invention discloses a medication answering method and device, electronic equipment and a storage medium. The method comprises the steps of obtaining a to-be-answered medication question, a knowledge base associated with the medication question and a large language model which is obtained by learning at least one candidate prompt word in advance and has a medication answering function; identifying a question category to which the medication question belongs, and determining a preliminary cue word matched with the question category in the at least one candidate cue word; according to the knowledge base and the medication problem, adjusting the preliminary cue word to obtain a target cue word; and inputting the target cue word into the large language model, so as to generate a drug use answer for solving the drug use problem according to the large language model and based on the target cue word. According to the technical scheme provided by the embodiment of the invention, the knowledge base is embedded into the large language model, so that the professionality of the medication solution generated by the large language model is improved by utilizing the knowledge base, and the accurate solution of the medication problem is ensured.

A system for delivering an aerosolized drug to a patient. The system includes a holding chamber (108), suitable to contain a drug to be aerosolized, and a connect element (100) having first and second ends, the second end being opposite to the first end and being suitable to be connected to the holding chamber (108). The connect element further comprises one or more mating mechanism (102, 104, 112, 114, 118) proximal its first end. The system can also include a mouthpiece (400), a drug assembly (200) including a drug housing (216) and a drug cartridge (300), and a vaporizer (500).

The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.

The invention relates to the technical field of blocking medicine bottles, and particularly discloses a blocking medicine bottle and a preparation method thereof, aiming at the problems that the upper limit of the blocking performance of the existing blocking medicine bottle is low and the blocking performance is difficult to break through due to the fact that the blocking performance of the existing blocking medicine bottle is mostly realized through structural design. A bottle body of the blocking medicine bottle comprises an inner layer, a secondary inner layer, a middle layer, a secondary outer layer and an outer layer which are sequentially arranged in a covering mode. The inner layer comprises polyethylene; the secondary inner layer comprises an ethylene-methyl acrylate copolymer; the middle layer comprises an ethylene-vinyl alcohol copolymer, cyclic polyolefin and modified montmorillonite; the secondary outer layer comprises an ethylene-methyl acrylate copolymer; the outer layer comprises polyethylene, cyclic polyolefin and modified montmorillonite. The barrier medicine bottle is formed by compositing five layers of materials, the oxygen and water transmittance is low, the barrier property is high, and the barrier medicine bottle has great application value in packaging of medicine or food and the like.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a gentiopicroside amide derivative, a synthesis method and application. A series of gentiopicroside amide derivatives are synthesized by taking gentiopicroside as a research object, carrying out structural modification on 6 '-site hydroxyl of gentiopicroside and introducing a benzoyl chloride group into a gentiopicroside structure. The synthetic method has the beneficial effects that on one hand, the synthetic method of the gentiopicroside amide derivative, which is mild in reaction condition and environment-friendly, is established; on the other hand, the 20 synthesized gentiopicroside amide derivatives have a remarkable inhibition effect on expression of LPS-induced THP-1 macrophage IL-6 and STAT3 protein content, the anti-inflammatory activity is remarkable, the action effect is superior to that of parent compound gentiopicroside, and a new thought is provided for preparation of STAT3 small-molecule inhibitors and anti-inflammatory drugs.

The invention discloses a lactobacillus paracasei SX-M1559 strain and application thereof in preparation of drugs for reducing blood sugar and lipid and resisting inflammation, and belongs to the technical field of microorganisms. The invention discloses a lactobacillus paracasei SX-M1559, and the preservation number of the lactobacillus paracasei SX-M1559 is CCTCC (China Center For Type Culture Collection) NO: M 2025030. According to the lactobacillus paracasei SX-M1559 and the application thereof in preparation of the medicine for reducing blood sugar, blood fat and inflammation, the SX-M1559 is separated from fresh feces of long-life old people, teai county, Zhanjiang city, Guangdong province, the glucose content in a zebra fish hyperglycemia model body and the fat content in a zebra fish hyperlipidemia model body can be remarkably reduced, and the effect of reducing blood sugar, blood fat and inflammation is achieved. The invention provides a theoretical reference and a guidance basis for developing a probiotic preparation for preventing or treating hyperlipidemia, diabetes mellitus and inflammatory bowel disease by utilizing the new strain SX-M1559 of the casei paracasei.

The invention discloses a drug-loaded liposome nano-particle, a preparation method thereof and application of the drug-loaded liposome nano-particle in treatment of brain glioma, and belongs to the technical field of biological nano-medicines. The invention provides a novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle and application of the novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle to treatment of brain glioma on the cellular level. The nano-particles are obtained by wrapping copper phthalocyanine derivatives and catalase with lipidosome prepared by a microfluidic method. The co-drug-loaded liposome can catalyze excessive H2O2 in brain glioma to generate oxygen, and O2 is continuously supplied to photodynamic therapy (PDT) to generate active oxygen; meanwhile, Cu < 2 + > can deplete glutathione and improve the oxidative stress level in the glioma, the reduction product Cu < + > can convert H2O2 into hydroxyl radicals with higher toxicity through a Fenton-like reaction, oxidative stress injury is doubly amplified, cascade cooperation of PDT and chemical dynamic therapy (CDT) is achieved, and the treatment effect on the glioma is remarkably enhanced.

The present invention discloses a compound represented by the following Formula (I) and a pharmaceutically acceptable salt thereof. The compound improves the THRα selectivity while maintaining good THRβ agonistic activity, thereby improving properties of the finished drug.

The invention relates to the technical field of medical apparatus and instruments, and discloses a long-acting gastric retention drug delivery device which can enter the stomach in an oral self-ingestion mode, further realizes size change through expansion of an elastic assembly, enhances the mechanical strength of the elastic assembly through a water-induced hard polymer, and avoids extrusion deformation and emptying through the pylorus of the stomach. The device comprises a medicine carrying assembly, an elastic assembly and a connecting assembly, the medicine carrying assembly comprises a plurality of medicine carrying pieces, and each medicine carrying piece is provided with a medicine carrying cavity. The elastic assembly comprises a plurality of elastic pieces, and the first ends of the elastic pieces are connected with one another, so that the elastic assembly is in a star shape in the unfolded state. The outer layer of the elastic assembly is coated with a reinforcing film, and the reinforcing film is formed by curing a water-hardened polymer and can be gradually converted into rigidity from flexibility in a water-based environment. The connecting assembly comprises a plurality of connecting pieces, the second end of one elastic piece is connected with one medicine carrying piece through one connecting piece, and the connecting pieces are decomposed under preset conditions, so that the medicine carrying pieces and the elastic assembly are separated and discharged out of the body in a non-invasive mode.

The invention relates to a mulberry leaf flavone microcapsule as well as a preparation method and application thereof, and belongs to the technical field of microcapsule drug loading. The preparation method of the mulberry leaf flavone microcapsule comprises the following steps: S1, adding mulberry leaf flavone into a chitosan solution, carrying out ultrasonic treatment, shearing by using a homogenizer, and heating and stirring to obtain a mixed solution; s2, slowly dropwise adding a sodium tripolyphosphate solution into the mixed solution, reacting and curing until the solution becomes milk white liquid from clear and no precipitate is generated, then centrifuging and washing, and collecting particles; and S3, freezing the particles, and performing freeze drying to obtain the mulberry leaf flavone microcapsules. The mulberry leaf flavone microcapsule provided by the invention can be used for developing a novel medicinal preparation in the field of medicines, and can relieve disease symptoms and delay disease progression through the antioxidant and anti-inflammatory characteristics of the mulberry leaf flavone microcapsule; in the field of food, the method can be applied to development of functional food, for example, the method can be added into beverages and health-care products to provide health benefits of antioxidation, blood fat reduction and the like for consumers.

The invention discloses a liver transplantation post-operation intelligent management system and method based on multi-modal monitoring and AI. The method comprises the following steps that S1, physiological parameters, biomarker data, iconography data and self-reporting data of a patient are collected in real time; s2, carrying out preprocessing, feature extraction and fusion on the collected data, and predicting the postoperative complication risk of the patient by using a risk prediction model; s3, generating a personalized management strategy by using a reinforcement learning algorithm according to a risk prediction result, and providing early warning information and intervention suggestions for medical personnel and patients; s4, according to the postoperative management plan and the doctor's advice of the patient, a fixed-point medication reminding function is set, a personalized medication scheme is generated, and medication compliance of the patient is monitored; and S5, the patient makes an appointment for remote medical services, selects appropriate doctors and time to carry out video inquiry or online consultation, and records inquiry content.

The invention relates to the technical field of food processing, in particular to cubilose nourishing, conditioning and blood sugar reducing health-care food and a preparation process thereof. The cubilose enters the palace from the clear generation, becomes a defending tonic, is a medicinal and edible tonic, and has the beauty of a rare famous drug and an oriental treasure. The cubilose is rich in sialic acid, protein, amino acid and other bioactive substances, so that the cubilose has a nourishing effect and has certain health-care and conditioning effects on the lung, the kidney and the stomach. According to the preparation method, the cherry and the honeysuckle are subjected to synergistic fermentation through the rhamnolactobacilli and the saccharomycetes, so that the performance is improved, and the prepared cubilose health-care food has the effect of reducing blood sugar.

The invention provides combination therapies comprising disease modifying anti-rheumatic drugs and mitochondrial complex I modulator (MCIM) compounds, which find utility in the medical field of inflammatory and progressive disorders, for example autoimmune diseases such as arthritis.

The present invention relates to N-palmitoyl ethanolamide for the treatment of inflammatory pain in combination with a non-steroidal anti-inflammatory drug, to the use of N-palmitoyl ethanolamide (referred to as palmitoyl ethanolamide or PEA) in combination with a non-steroidal anti-inflammatory drug for the treatment of inflammatory pain. Specifically, the present invention relates to palmitoyl ethanolamide for use in the treatment of inflammatory pain, in particular non-neurological inflammatory pain, in which palmitoyl ethanolamide is administered in combination or in combination with a non-steroidal anti-inflammatory drug as needed, in which the administration is separate, combined or simultaneous.

The invention relates to the technical field of intelligent management, in particular to an intelligent medicine safety management system based on voice navigation and an application method of the intelligent medicine safety management system. The storage unit is arranged to be used for storing a plurality of medical articles, and the medical articles are provided with attribute information including the valid period; the triggering module is used for opening the storage unit and triggering and reminding the position of the matched medical article or triggering the medical article to be discharged to the medicine outlet; the identity recognition module is used for recognizing personnel information of personnel operating the mobile medicine vehicle; and the voice control module is configured to receive voice information of a person at first, then identify key information including the medical articles from the voice information, then find the positions of the corresponding medical articles from the storage unit, and then transmit the position information to the trigger module to obtain the corresponding medical articles. The defects of an intelligent management system in the aspects of traceability and accurate management are overcome.

The invention relates to 2 '-fucosyllactose, in particular to application of the 2'-fucosyllactose to preparation of immune balance drugs or food. The immune balance comprises regulation and control of the ratio of Th17 cells to Treg cells of Th17 / Treg immune imbalance offspring activated by maternal immune or induced by virus infection; according to the application disclosed by the invention, the fact that filial generations generated after the maternal body of a mammal generates immune reaction activation can regulate and control the proportion of Th17 and Treg cells through the influence of 2 '-fucosyllactose on intestinal flora is found, so that Th17 and Treg immune balance is realized; in addition, social and cognitive disorders and repetitive behaviors related to filial generation autism induced by Th17 / Treg immune imbalance can be improved.

Provided are methods for combination treatment of a cancer using an antibody-drug conjugate (ADC) targeting CEACAM5 and an anti-PD-1 antibody or anti-PD-L1 antibody, optionally together with a platinum-containing agent such as cisplatin or carboplatin with or without pemetrexed. In certain embodiments the ADC is tusamitamab ravtansine. In certain embodiments the anti-PD-1 antibody is pembrolizumab. In certain embodiments, the cancer is nonsquamous non-small cell lung cancer (NSQ NSCLC). In certain embodiments, the cancer is advanced or metastatic NSQ NSCLC.

The invention discloses an enantiokaurane compound with antitumor activity as well as a preparation method and application of the enantiokaurane compound. According to the present invention, chemical components of Western African plant I.trichantha tubers are deeply studied, and a variety of chromatographic separation methods such as macroporous resin, silica gel resin, medium pressure preparation-MCI column, gel normal pressure column and semi-preparative high performance liquid chromatography are combined to separate to obtain one enantiokaurane new compound Trichanthone B; experiments show that the compound obtained through separation has a good inhibition effect on an MIA PaCa-2 pancreatic cancer cell line and an A549 lung cancer cell line, and IC50 of the compound on the MIA PaCa-2 pancreatic cancer cell line reaches a nanomole level; the effect of the compound is stronger than that of positive drugs 5-fluorouracil and carboplatin, and the compound has the potential of being developed into new drugs for resisting pancreatic cancer and lung cancer.

Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia, dystonia, akathisia, or drug-induced Parkinsonism, with the administration of a therapeutic effective amount of Trapidil, a derivative, a metabolite, a prodrug, an analog, or a pharmaceutically acceptable salt thereof.

The invention discloses an edible and medicinal composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition consists of the following raw materials in parts by weight: 1-8 parts of ampelopsis grossedentata extract freeze-dried powder, 1-8 parts of astragalus membranaceus extract freeze-dried powder, 1-5 parts of kudzu vine root extract freeze-dried powder, 1-8 parts of hawthorn extract freeze-dried powder and 1-5 parts of cassia seed extract freeze-dried powder. The composition is designed according to a multi-component synergistic interaction principle, and the functions of protecting the liver and dispelling the effects of alcohol are enhanced through targeted interaction of active ingredients such as ampelopsis grossedentata flavone, puerarin and astragaloside; the compound preparation has the compound effects of protecting the liver, dispelling the effects of alcohol, resolving dampness, resisting oxidative stress, regulating lipid metabolism and the like, can remarkably relieve the problems of acute and chronic liver injury and metabolic disorder caused by alcohol intake, and meets the food-grade safety standard and the medicinal activity requirement; the important application prospect is realized in the aspect of preparing a preparation for relieving alcoholic liver injury and improving the liver detoxification function.

Embodiments herein are directed to a vascular stenosis treatment apparatus including a treatment assembly having a balloon, the wall of the balloon being provided with a plurality of first holes for liquid to pass through, and the balloon having an unexpanded state and an expanded state; a covering member covering the outside of the balloon and expanding with the expansion of the balloon, the covering member having a plurality of second holes, and when the balloon is in the expanded state, the aperture of the first holes being smaller than the aperture of the second holes. The treatment apparatus can achieve accurate positioning, and the covering member has a limiting effect on a drug solution causing the drug to more uniformly and effectively act on a desired position of a vascular wall, increasing the utilization rate, reducing the occurrence rate of vascular restenosis, and improving the treatment effect.