120 results about "Drugs solution" patented technology

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L / min to 60 L / min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL / hour and 50 mL / hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

The invention relates to the technical field of extracellular vesicles, in particular to an extracellular vesicle active drug loading method which comprises the following preparation steps: S1, collecting cell supernatant, collecting the cell supernatant under the condition of 4 DEG C, and performing multi-stage centrifugation to remove impurities to obtain purified extracellular vesicles; s2, dissolving a target drug in a corresponding solvent to prepare a drug solution with the concentration of 0.1-5 mg / mL; s3, mixing the purified extracellular vesicles obtained in S1 with the medicine solution obtained in S2 according to the volume ratio of 1: 1, and performing low-frequency ultrasonic treatment in a pulse mode under the ice bath condition of 4 DEG C; s4, incubating the mixed system subjected to ultrasonic treatment at 37 DEG C for 25-35 minutes, and meanwhile, adding a cholesterol solution with the final concentration of 0.005-0.01% to assist membrane repair; the problems of contradiction between the drug loading efficiency and the integrity of the extracellular vesicles, poor drug universality, low purification efficiency and insufficient application stability in the existing active drug loading technology of the extracellular vesicles are specifically solved through the whole process optimization of precise purification, efficient drug loading, directional repair and deep refining.

An information management system (10) comprises a drug solution administration device (12) and an information management device (14). The drug solution administration device comprises a transmission control unit (104) that transmits information acquired using a sensor (86) provided to the drug solution administration device to the information management device. The information management device comprises a reception control unit (124) that receives the information transmitted by the transmission control unit and a determination unit (128) that, on the basis of the information received by the reception control unit, determines whether a drug solution administration amount has reached a predetermined required administration amount.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

A pyridine amide compound-containing composition and a pharmaceutical composition, a preparation method therefor and a use thereof. The composition comprises an active ingredient and at least one matrix material, wherein the active ingredient is a compound represented by formula I or a pharmaceutically acceptable salt, a stereoisomer, a solvate, an isotopically labeled compound, a polymorph, a metabolite or a prodrug thereof. The composition has a high drug loading capacity, improves drug solubility, and has good stability. The in vivo bioavailability of the composition can reach the same level of bioavailability as that of a clear drug solution.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

This invention discloses a multi-stage dosing device and method for a concentrated liquid flocculation tank, relating to the technical field of dosing equipment. It includes: a fixed frame, disposed on the top of the tank, with a track rod fixedly connected to the end of the fixed frame, and a housing slidably connected to the track rod; a ring-shaped airbag fixedly connected to the top edge of the housing; a dosing device, arranged in a circumferential array on the housing, comprising: a ring pipe, with a delivery pipe circumferentially connected to the ring pipe, one end of the delivery pipe connected to the ring pipe and the other end fixedly connected to the housing and extending into the tank; an inlet device for supplying the drug solution to the ring pipe; and a slow-release device, arranged in a circumferential array on the housing, with an opening and closing device on the housing for adjusting the drug output of the slow-release device.

The invention provides a special lung atomization therapeutic apparatus for the internal medicine of traditional Chinese medicine, and relates to the technical field of medical instruments, the special lung atomization therapeutic apparatus comprises an atomizer body, an atomization tank, a mist discharging pipe and a connecting pipe, the connecting pipe is inserted into a connecting plug at the bottom end of the atomization tank, and the other end of the connecting pipe is inserted into the air outlet end of the atomizer body; the double-cavity isolation type atomization tank is adopted, and aiming at the scene that salbutamol sulfate, budesonide and the like are compatible but need to be dosed for several times, through the design of the upper-layer independent medicine storage cavity, the lower-layer independent medicine storage cavity and the isolation gas circuit, the medicine can be dosed for several times, and the medicine can be dosed for several times. After the first liquid medicine is atomized, treatment is not required to be interrupted to replace a container or detach an air pipe, and the second medicine can be quickly switched only by cleaning the mask, so that the problems of tedious operation and treatment interruption of fractional atomization of a single medicine tank are solved, and tiny physical and chemical influence possibly caused by advanced mixing of a large amount of liquid medicine is avoided; and meanwhile, the operation time in the emergency scene is remarkably shortened.

The application discloses a breath actuated inhaler. The inhaler comprises a main housing having a suction port at a distal end, a canister storing a drug solution and disposed axially within the main housing, and a force retention unit attached to the main housing and engaged with the canister, comprising an upper housing having an air intake structure disposed at a proximal end, the air inlet structure and the suction port form an air circulation path, so that the force maintaining unit responds to inhalation of a user to start the tank; wherein the air inlet structure comprises at least two holes with main openings, and the at least two holes are annularly arranged at the near end of the upper shell in an end-to-end connection mode, so that the main openings of all the holes cannot be completely covered when fingers are placed on the end face of the near end during inhalation of a user.

To provide a personal dialysis machine that allows for visual confirmation of the remaining amount of concentrated dialysis solution with a simple configuration, while suppressing cost increases. [Solution] The personal dialysis machine 100 includes drug solution tanks 95, 96 and drug solution solenoid valves 81, 82 for storing drug solution for cleaning the piping 5, and concentrate tanks 93, 94 and concentrate solenoid valves 83, 84 for storing concentrate for dialysis fluid, and includes a drug solution concentrate usage determination unit 51 that determines the amount of at least one of the drug solution and concentrate that has been drawn up by the pump 86, a drug solution concentrate remaining amount calculation unit 52 that calculates the remaining amount of drug solution concentrate based on the amount determined by the drug solution concentrate usage determination unit 51, a drug solution concentrate remaining amount determination unit 55 that determines whether the remaining amount of drug solution concentrate is less than a predetermined standard amount, and a display unit 60 that displays a fact if the remaining amount of drug solution concentrate is less than a predetermined standard amount.

In one embodiment, a method includes obtaining a measurement representative of an electrical impedance within a fluid channel of an implantable medical device; and processing the measurements to determine whether the implantable medical device is perfused for implantation in a recipient. The implantable medical device may include: an implantable drug reservoir having a loading port for receiving a drug solution; a drug delivery lumen having at least one release port and configured to be implanted within a recipient; and an intermediate drug lumen extending from the implantable drug reservoir to the drug delivery lumen to form a fluid path between the loading port and the at least one release port. The implantable medical device is configured to be infused with a drug prior to implantation in a recipient. The fluid path is electrically discontinuous in the absence of the conductive solution.

Unit dosage forms, devices, and kits for topical delivery of topical immunosensitizers are provided. These include dermal patches, glass swabs, and kits containing a dermal patch and a glass swab. Among other advantages, the unit dosage forms, devices, and kits presented herein deliver a more consistent and controlled volume of drug solution, prevent underdosing and overdosing, prevent or discourage repeat dosing, and provide a more consistent skin area to which the drug solution is applied.

To provide a protective sheet which protects a puncture site without being directly attached to a user's body, allows easy visual confirmation of the state of the puncture site during protection, and can be quickly released in an emergency such as when a drug solution leaks or a needle comes out, and is easy to attach and detach. A protective sheet (1) for preventing accidental withdrawal of the needle during puncture is attached to the puncture site without being directly attached to the body of the user (5). The puncture site and the puncture needles 6a, 6b and tubes 7a, 7b connected to the puncture site are covered. and an adhesive portion 2 for fixing the protective sheet 1 in a wrapped state. , the adhesive portion 2 A non-porous part 3 that has no temper , the through hole adjacent to the non-perforated portion 3 and a perforated portion 4 having a temper. The adhesive portion 2 is provided only on one end of the protective sheet 1. The perforated portion 3 and the perforated portion 4 are not adhesive and are configured not to stick to the body of the user 5 during use.

This invention relates to the field of medical nebulizer technology, and more particularly to an automated nebulization therapy device and method, comprising a housing, a control system, and a power system. The housing contains a drug preparation chamber, a first nebulization chamber, a second nebulization chamber, and a water chamber. Through the installation of a distilled water pump, a water level monitoring system, a first electric valve, a drug solution level detection system, a drug solution mixing system, a drug solution mixing monitoring system, a second electric valve, and the nebulization system, automated control and nebulization of drug preparation and administration are achieved. This eliminates the need for manual drug preparation by medical personnel, avoiding the problem of poor treatment effects caused by uneven drug preparation and reducing the workload of medical staff. Simultaneously, the device can automatically clean itself, avoiding the impact on the treatment effect of the next patient due to inconsistent cleaning standards during manual cleaning. This solves the problems of high workload for manual drug preparation, poor nebulization effect, and low efficiency caused by uneven drug mixing in existing technologies.

The present application relates to a kind of methods for reducing the residue of liquid medicine filtering system, the filtering system includes filter valve body, inlet pipe, outlet pipe and exhaust pipe are connected to the filter valve body, first valve body is installed on the exhaust pipe, inlet pipe is connected to the outlet pipe, second valve body is arranged between the inlet pipe and filter valve body, third valve body is installed on the inlet pipe, discharge pipe is connected to the outlet pipe end, the outlet pipe is obliquely arranged, by sequentially opening and closing between each valve body, gas is discharged from the liquid medicine remaining in filter valve body, thereby effectively saving data, reduce production cost.

The invention provides a multi-dimensional electronic regulation and control microneedle injection medicine introduction system, and belongs to the technical field of medical instruments. The system comprises a shell, a user interaction module, a control and drive module, a drive execution module and a microneedle module integrated with an adjustment protection device. The user interaction module is used for realizing multi-parameter collaborative setting and real-time display of injection pressure, dose and speed through a display screen and a control key; the control and driving module generates a regulation and control instruction according to the set parameters; the driving execution module accurately controls liquid medicine conveying according to the instruction; an adjusting protection device of the microneedle module can control the penetration depth of the microneedle and provide protection when the microneedle module is not used. By means of electronic integrated control, multi-dimensional, quantifiable and self-adaptive precise regulation and control of the drug introduction process are achieved, the safety, effectiveness and operation convenience of injection are effectively improved, and the system is suitable for various drug administration scenes such as clinic and families.

The invention discloses an injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) respectively dissolving Gelma and HAMA in sterile PBS (Phosphate Buffer Solution) according to the dosage required by a final system; 2) mixing the two solutions, and adding a photoinitiator LAP pre-dissolved in the sterile PBS at 60 DEG C; 3) dissolving golden larch bark acetic acid in dimethyl sulfoxide to prepare a medicine solution with the concentration of 1.0 mg / mL, and then adding the medicine solution into the precursor solution under the condition of continuous stirring; and 4) carrying out 405 nm illumination crosslinking on the obtained precursor solution to form the hydrogel. The hydrogel three-dimensional network can continuously and controllably release pseudolaric acid, maintains a long-acting effective drug concentration at an infected part, shows a strong inhibition effect on a candida albicans standard strain and a clinical drug-resistant strain, and has a good application prospect in a model for treating candida vaginitis and fungal skin wound infection. And all the components show a remarkable'anti-infection-repair promoting 'integrated treatment effect.

The present invention provides a drug solution bottle unit having a structure capable of reducing the amount of force required to press the tray when opening the respective lid members of two drug solution bottles. To this end, a drug solution bottle unit 10 according to the present invention comprises: a first bottle 11 having an interior sealed by a first lid 17; and a second bottle 12 having an interior sealed by a second lid 18. The first lid is provided on a first end face 11a of the first bottle, and the second lid is provided on a first end face 12a of the second bottle. The first lid and the second lid are arranged at positions differing in distance from respective second end faces 11b and 12b of the first bottle and the second bottle. The first bottle has a first region 13 for filling liquid, and the second bottle has a second region 14 for filling liquid. The second region includes a first accommodation portion and a protrusion 12d that communicates with the first accommodation portion to form the second region.

The utility model discloses a sampling device for medicine detection, which comprises a box body, the top of the box body is fixedly connected with a handle, the front side of the box body is rotatably connected with a box door, the right side of the front side of the box door is fixedly connected with a handle, and the opposite sides of the box body and the box door are fixedly connected with magnets. A containing frame is fixedly connected to the left side of the bottom of the box body, a containing seat is fixedly connected to the right side of the bottom of the box body, an adjusting mechanism is arranged in the box body, an extrusion mechanism is arranged in the box body, a limiting mechanism is arranged in the box body, and the adjusting mechanism comprises an air cylinder fixedly installed on the inner top wall of the box body. An output shaft of the air cylinder is fixedly connected with a lifting plate. The sampling device can be stretched and extruded through the piston rod of the needle cylinder, so that liquid medicine can be conveniently sucked and released, and the working efficiency of the sampling device is further improved.

The utility model relates to the field of sewage treatment, and discloses an efficient hydrolysis acidification pool which comprises a pool body, the inner wall of the pool body is fixedly connected with a partition plate, the left side of the partition plate is provided with an acceleration mechanism, the acceleration mechanism comprises a rotating rod, the front end of the rotating rod is rotatably connected with the inner wall of the pool body, the outer wall of the pool body is fixedly connected with a storage plate, and the storage plate is fixedly connected with the inner wall of the pool body. A pesticide box is fixedly connected to the top end of the storage plate, a communicating pipe penetrates through and is fixedly connected to the inner wall, close to the bottom, of the pesticide box, a pesticide outlet strip penetrates through and is fixedly connected to the inner wall of the communicating pipe, a movable pipe is connected to an inner wall piston of the pesticide outlet strip, and an eccentric wheel is fixedly connected to the outer wall of a rotating rod. According to the utility model, through the arrangement of the accelerating mechanism, the liquid medicine can slowly enter the water body in the flowing process of the water body, so that the liquid medicine and the water body are conveniently fused, and meanwhile, the flowing speed of the water body is accelerated through the rotation of the stirring blades, so that the effect of increasing the hydrolysis speed is achieved.

This invention discloses an experimental zebrafish drug screening auxiliary device in the field of biological experimental auxiliary devices. It includes a carrier with several culture wells circumferentially opened at the top. A first mixing chamber and a second mixing chamber are formed within the carrier. The first mixing chamber is connected to an inlet mechanism for delivering drug solution into the first mixing chamber. A transfer mixing mechanism is provided within the first mixing chamber to homogenize the drug solution based on the boundary layer effect and deliver the drug solution to the second mixing chamber. A transfer mechanism is connected to the end of the second mixing chamber away from the first mixing chamber to connect the first and second mixing chambers. An isolation mechanism connects the culture wells and the second mixing chamber to control the connection between the two chambers. This invention can quickly and efficiently achieve uniform dispersion of the drug solution throughout the entire well area, thereby improving the reliability of experimental data.

This utility model belongs to the field of medical device technology, and particularly relates to a drug delivery device for cancer patients, including a protective box. A drug solution tank is threadedly installed on the top of the protective box. A partition plate is provided in the lower middle part of the drug solution tank, dividing the inner cavity of the drug solution tank into an upper drug storage chamber and a lower drive chamber. By setting up the protective box and the drug solution tank, the cartridge and needle can be retracted into the inner cavity of the protective box when not in use, thereby protecting the cartridge and needle and preventing the needle from being exposed to the external environment for a long time and causing infection. This provides effective protection for both the device and the patient. By setting up a drive component, a motor is used to provide driving force, replacing the traditional method of manually controlling the displacement of the cartridge, which greatly saves manpower and improves the efficiency and comfort of the device.

Devices, systems, and methods for localized delivery of a chemotherapy, hormonal therapy, or targeted drug / biologic therapy to a target tissue area of an internal body organ of a patient. Computer systems may be used for planning and navigation in super selective drug delivery via a tracheobronchial airway. A catheter may be used to form a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin to saturate the target tissue area. The chamber is evacuated at the end of the treatment session.

This invention provides a laboratory water tank for reducing the concentration of suspended solids in pharmaceutical solutions. The tank comprises a square tank with a downward-sloping central area. Within this recessed area, from top to bottom, are arranged the following: a sedimentation separation zone for preliminary solid-liquid separation of the liquid entering the tank; a filtration and adsorption zone connected to the lower end of the sedimentation separation zone for filtering and adsorbing the pre-separated liquid; and a purified liquid discharge zone connected to the lower end of the filtration and adsorption zone and connected to an external drainage pipe. This invention integrates sedimentation separation, multi-stage filtration, and adsorption functions, effectively intercepting and removing large particles of pharmaceutical residue and fine suspended solids from waste pharmaceutical solutions, while also effectively reducing dissolved organic matter, pigments, and odors, thus achieving effective pretreatment of laboratory waste pharmaceutical solutions at the source of discharge.

The invention discloses an electrochemically-driven small drug delivery device and a preparation method and application thereof, the device comprises an interdigital electrode, an electrolyte chamber, a flexible film, a drug storage chamber and a microfluidic channel which are stacked in sequence, and is provided with an electrolyte filling port, a drug filling port and a polyethylene conduit communicated with the microfluidic channel. The device works based on a water electrolysis reaction in the electrolyte chamber, voltage is applied to the interdigital electrode, so that a sodium hydroxide solution is electrolyzed to generate hydrogen and oxygen, the flexible film is deformed upwards under gas pressure, and then a medicine solution in the medicine storage chamber is extruded to be discharged from the guide pipe through the microfluidic channel. And the on-demand and controllable release of the medicine can be realized by adjusting the magnitude of the voltage and the action time. The device disclosed by the invention is compact in structure, simple in preparation process and low in cost, is assembled by adopting a commercial silica gel adhesive, is convenient to disassemble and repeatedly inject, is suitable for batch production, and has a better application prospect in a miniaturized and low-power-consumption drug delivery system.

The present invention provides a pharmaceutical composition containing a benzodiazepine drug. [Solution] A drug solution for intranasal administration is provided, comprising: (a) a benzodiazepine drug; (b) one or more natural or synthetic tocopherols or tocotrienols, or any combination thereof, in an amount of about 30% to about 95% (w / w); (c) one or more alcohols or glycols, or any combination thereof, in an amount of about 10% to about 70% (w / w); and (d) an alkyl glycoside.

This invention discloses a cochlear implant drug delivery device, including a drug delivery power mechanism for transporting drug solution through a microcatheter and a drug delivery channel to a drug release port. The drug delivery power mechanism includes an external control component and an internal delivery component disposed on the microcatheter. The external control component includes a first magnetic roller portion, and the internal delivery component includes a second magnetic roller portion for magnetic coupling with the first magnetic roller portion. The second magnetic roller portion controls the quantitative delivery of drug solution from the microcatheter to the drug delivery channel by rotation. When the second magnetic roller portion is magnetically coupled with the first magnetic roller portion, the second magnetic roller portion rotates accordingly based on the rotation angle of the first magnetic roller portion. The cochlear implant drug delivery device of this invention can quantitatively deliver drug solution to the drug release port from outside the body, has a simple structure, is easy to implement, requires no surgical implantation or replacement, and precisely controls the drug delivery.

This invention discloses a method for determining the encapsulation efficiency of amphotericin B liposomes for injection, comprising the following steps: separating the amphotericin B liposome solution for injection using solid-phase extraction adsorption to obtain an encapsulated drug solution and a free drug solution; and determining the drug mass concentration C in the encapsulated drug solution using HPLC. 包封 Drug mass concentration C in free drug solution 游离 And the total drug concentration C in the amphotericin B liposome solution before separation 总 The encapsulation efficiency and recovery rate of amphotericin B liposomes were calculated. This invention utilizes a macroporous copolymer of divinylbenzene and N-vinylpyrrolidone as the adsorbent in a solid-phase extraction adsorption method. Its macroporous structure provides ample adsorption sites while avoiding physical compression and damage to the liposome vesicles. This method achieves the separation of free amphotericin B liposomes from the encapsulated drug, exhibiting good reproducibility, high accuracy, simple operation, and high recovery rate.

To provide a structure capable of detecting that a chemical bottle unit is surely mounted at a prescribed position inside a device.SOLUTION: The present invention provides a chemical liquid bottle unit configured by combining at least two bottles, the chemical liquid bottle unit including a first bottle that stores a first chemical liquid and a second bottle that stores a second chemical liquid, the first bottle including an opening and a first container body that stores the first chemical liquid, the second bottle including an opening and a second container body that stores the second chemical liquid, the first container body including a first step portion for detection, the second container body including a second step portion for detection, the first bottle and the second bottle are substantially L-shaped, and when combined, the first container body and the second container body form a substantially rectangular parallelepiped shape.SELECTED DRAWING: Figure 7

Provided are a multilayer film for a container, a container comprising the multilayer film, a method for manufacturing the container comprising the multilayer film, and a medical container containing a drug solution and containing the drug solution, the multilayer film being capable of suppressing oxidative deterioration of contents by oxygen remaining in the container or the contents and / or oxygen that permeates into the container, and also capable of suppressing oxidative deterioration of the contents by oxygen that remains in the container and / or the oxygen that permeates into the container, the container comprising the multilayer film, the method for manufacturing the container comprising the multilayer film, and the medical container containing the drug solution. As a result, it is possible to suppress adsorption of the contents on the film constituting the container, decrease in drug efficacy and adsorption of flavor substances, increase in the amount of the contents adsorbed on the film during the distillation step, uneven deformation of the film and occurrence of unevenness of the surface, and deformation of the container. A multilayer film for a container comprises: an outer film which is a transparent oxygen barrier film; an intermediate film which is a co-extruded film having an oxygen-absorbing layer; and an inner film which is a co-extruded film having a cyclic polyolefin layer containing a cyclic polyolefin, in which the intermediate film has a symmetrical laminated structure having a surface layer with the oxygen-absorbing layer as a core layer, and the inner film has a symmetrical laminated structure having a surface layer with the cyclic polyolefin layer as a core layer.