206 results about "Drugs solution" patented technology

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L / min to 60 L / min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL / hour and 50 mL / hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

The utility model discloses a biopharmaceutical sampler which comprises a sampling barrel, a push rod, a sealing plug, a sampling opening, a measuring scale, a protective cover, a sealing mechanism, a filter layer, a cleaning brush, scale marks, an exhaust valve and a fixing ring, the biopharmaceutical sampling device is reasonable and simple in structure, low in production cost, convenient to install and complete in function, the biopharmaceutical sampling amount can be accurately controlled through the arranged measuring scale and scale marks, and the accuracy of experimental data is improved; impurities in liquid medicine are effectively filtered through the filter layer, the purity of sampling is ensured, and the accuracy of follow-up detection and analysis is facilitated; the inner wall of the sampling barrel is convenient to clean through the cleaning brush, cross contamination among different samples is avoided, and independence and accuracy of sampling each time are guaranteed.

The invention relates to the technical field of extracellular vesicles, in particular to an extracellular vesicle active drug loading method which comprises the following preparation steps: S1, collecting cell supernatant, collecting the cell supernatant under the condition of 4 DEG C, and performing multi-stage centrifugation to remove impurities to obtain purified extracellular vesicles; s2, dissolving a target drug in a corresponding solvent to prepare a drug solution with the concentration of 0.1-5 mg / mL; s3, mixing the purified extracellular vesicles obtained in S1 with the medicine solution obtained in S2 according to the volume ratio of 1: 1, and performing low-frequency ultrasonic treatment in a pulse mode under the ice bath condition of 4 DEG C; s4, incubating the mixed system subjected to ultrasonic treatment at 37 DEG C for 25-35 minutes, and meanwhile, adding a cholesterol solution with the final concentration of 0.005-0.01% to assist membrane repair; the problems of contradiction between the drug loading efficiency and the integrity of the extracellular vesicles, poor drug universality, low purification efficiency and insufficient application stability in the existing active drug loading technology of the extracellular vesicles are specifically solved through the whole process optimization of precise purification, efficient drug loading, directional repair and deep refining.

The invention discloses a pH response hydrogel microneedle, which comprises a microneedle substrate, microneedle tips are arranged on the microneedle substrate, the height of the microneedle tips is 100-1600 microns, the diameter of the tip ends of the microneedle tips is 5-15 microns, and the density of the microneedle tips is 200-1000 pieces per square centimeter. The preparation method comprises the following steps: preparing a hyaluronic acid solution for the microneedle substrate, preparing a methacrylated chondroitin sulfate solution for the microneedle tip, preparing methacrylated orthoester, preparing orthoester, preparing a non-steroidal anti-inflammatory drug solution, preparing a microneedle tip solution, preparing the microneedle and demolding the microneedle to prepare the complete soluble microneedle patch. The invention has the advantages of high drug efficiency, high efficiency in dissolving fat / water drugs, and long-acting slow release.

An information management system (10) comprises a drug solution administration device (12) and an information management device (14). The drug solution administration device comprises a transmission control unit (104) that transmits information acquired using a sensor (86) provided to the drug solution administration device to the information management device. The information management device comprises a reception control unit (124) that receives the information transmitted by the transmission control unit and a determination unit (128) that, on the basis of the information received by the reception control unit, determines whether a drug solution administration amount has reached a predetermined required administration amount.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

A pyridine amide compound-containing composition and a pharmaceutical composition, a preparation method therefor and a use thereof. The composition comprises an active ingredient and at least one matrix material, wherein the active ingredient is a compound represented by formula I or a pharmaceutically acceptable salt, a stereoisomer, a solvate, an isotopically labeled compound, a polymorph, a metabolite or a prodrug thereof. The composition has a high drug loading capacity, improves drug solubility, and has good stability. The in vivo bioavailability of the composition can reach the same level of bioavailability as that of a clear drug solution.

Provided is a drug solution administration device (1) for administering a drug solution filled in a reservoir (18), the drug solution administration device (1) comprising a pump body (10) provided with: a pump for transporting the drug solution filled in the reservoir (18); a rechargeable battery (42) for supplying power for driving the pump; a measurement unit (76) for measuring the remaining charge of the rechargeable battery (42); and a control unit (71). If the remaining charge of the rechargeable battery (42) measured by the measurement unit (76) is greater than a predetermined threshold value, the control unit (71) notifies a user that the rechargeable battery (42) is fully charged.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

This invention discloses a multi-stage dosing device and method for a concentrated liquid flocculation tank, relating to the technical field of dosing equipment. It includes: a fixed frame, disposed on the top of the tank, with a track rod fixedly connected to the end of the fixed frame, and a housing slidably connected to the track rod; a ring-shaped airbag fixedly connected to the top edge of the housing; a dosing device, arranged in a circumferential array on the housing, comprising: a ring pipe, with a delivery pipe circumferentially connected to the ring pipe, one end of the delivery pipe connected to the ring pipe and the other end fixedly connected to the housing and extending into the tank; an inlet device for supplying the drug solution to the ring pipe; and a slow-release device, arranged in a circumferential array on the housing, with an opening and closing device on the housing for adjusting the drug output of the slow-release device.

The invention provides a special lung atomization therapeutic apparatus for the internal medicine of traditional Chinese medicine, and relates to the technical field of medical instruments, the special lung atomization therapeutic apparatus comprises an atomizer body, an atomization tank, a mist discharging pipe and a connecting pipe, the connecting pipe is inserted into a connecting plug at the bottom end of the atomization tank, and the other end of the connecting pipe is inserted into the air outlet end of the atomizer body; the double-cavity isolation type atomization tank is adopted, and aiming at the scene that salbutamol sulfate, budesonide and the like are compatible but need to be dosed for several times, through the design of the upper-layer independent medicine storage cavity, the lower-layer independent medicine storage cavity and the isolation gas circuit, the medicine can be dosed for several times, and the medicine can be dosed for several times. After the first liquid medicine is atomized, treatment is not required to be interrupted to replace a container or detach an air pipe, and the second medicine can be quickly switched only by cleaning the mask, so that the problems of tedious operation and treatment interruption of fractional atomization of a single medicine tank are solved, and tiny physical and chemical influence possibly caused by advanced mixing of a large amount of liquid medicine is avoided; and meanwhile, the operation time in the emergency scene is remarkably shortened.

The invention belongs to the technical field of medicines, and discloses a betahistine mesylate oral soluble film agent for treating meniere disease, meniere syndrome and vertigo symptoms caused by vertigo and a preparation process thereof, the preparation process comprises the following steps: (1) adding betahistine mesylate into purified water; (2) adding glycerol, citric acid, sucralose, liquid orange-flavored essence and sunset yellow into the raw material medicine solution; (3) taking HPMC-E15, dispersing the HPMC-E15 in purified water, and adding HPC-LXF for thickening; (4) adding the medicine-containing solution into the blank glue solution; (5) degassing; (6) coating; and (7) cutting and packaging. Compared with a common tablet, the oral soluble film disclosed by the invention has a higher release rate, and can enter a body through a sublingual vein way in addition to a conventional gastrointestinal tract absorption way after being dissolved in an oral cavity, so that the bioavailability is increased; under the condition of stability acceleration, the compound has a better impurity level, and the preparation process is simple to operate, high in repeatability and suitable for industrial large-scale production.

The application discloses a breath actuated inhaler. The inhaler comprises a main housing having a suction port at a distal end, a canister storing a drug solution and disposed axially within the main housing, and a force retention unit attached to the main housing and engaged with the canister, comprising an upper housing having an air intake structure disposed at a proximal end, the air inlet structure and the suction port form an air circulation path, so that the force maintaining unit responds to inhalation of a user to start the tank; wherein the air inlet structure comprises at least two holes with main openings, and the at least two holes are annularly arranged at the near end of the upper shell in an end-to-end connection mode, so that the main openings of all the holes cannot be completely covered when fingers are placed on the end face of the near end during inhalation of a user.

To provide a personal dialysis machine that allows for visual confirmation of the remaining amount of concentrated dialysis solution with a simple configuration, while suppressing cost increases. [Solution] The personal dialysis machine 100 includes drug solution tanks 95, 96 and drug solution solenoid valves 81, 82 for storing drug solution for cleaning the piping 5, and concentrate tanks 93, 94 and concentrate solenoid valves 83, 84 for storing concentrate for dialysis fluid, and includes a drug solution concentrate usage determination unit 51 that determines the amount of at least one of the drug solution and concentrate that has been drawn up by the pump 86, a drug solution concentrate remaining amount calculation unit 52 that calculates the remaining amount of drug solution concentrate based on the amount determined by the drug solution concentrate usage determination unit 51, a drug solution concentrate remaining amount determination unit 55 that determines whether the remaining amount of drug solution concentrate is less than a predetermined standard amount, and a display unit 60 that displays a fact if the remaining amount of drug solution concentrate is less than a predetermined standard amount.

A cleaning / disinfecting device 1 comprises: a device body 2 capable of holding a drug solution bottle unit 7 to which are attached first to third color labels 19a -19c; a non-contact type color sensor 9 that detects each color of the first to third color labels 19a -19c in accordance with the position of the drug solution bottle unit 7 which moves inside the device body 2; and a processor 10a that determines the position of the drug solution bottle unit 7 on the basis of a detection signal from the color sensor 9.

The utility model discloses a portable medicine atomization device which comprises a pipe body shell, a bearing groove is formed in the top end of the pipe body shell, a containing tank is assembled on the bearing groove, a butt joint opening is formed in one side of the containing tank, and a sealing cover is arranged at the top of the containing tank. An ultrasonic wafer is arranged in the center of the containing tank, and an ultrasonic conduction groove is formed in the top end of the center of the pipe body shell and connected with the ultrasonic wafer. The utility model relates to the technical field of atomization equipment, and the portable medicine atomization equipment adopts an ultrasonic atomization mode to atomize liquid medicine, is simple in structure, is smaller in structure and convenient to carry compared with a high-pressure atomization mode, further divides a containing tank into a medicine containing groove and a vent groove through a sealing plate integrally arranged on the containing tank, and is convenient to carry. Through the arrangement of the double one-way valves, when a person breathes, medicine atomization jet flow is blocked and started, and a user can better adapt to the rhythm of atomization breathing.

In one embodiment, a method includes obtaining a measurement representative of an electrical impedance within a fluid channel of an implantable medical device; and processing the measurements to determine whether the implantable medical device is perfused for implantation in a recipient. The implantable medical device may include: an implantable drug reservoir having a loading port for receiving a drug solution; a drug delivery lumen having at least one release port and configured to be implanted within a recipient; and an intermediate drug lumen extending from the implantable drug reservoir to the drug delivery lumen to form a fluid path between the loading port and the at least one release port. The implantable medical device is configured to be infused with a drug prior to implantation in a recipient. The fluid path is electrically discontinuous in the absence of the conductive solution.

The utility model relates to the technical field of medicine feeders, in particular to a portable medicine feeder for mental patients, which comprises a tube body, a push plate is arranged on the inner side wall of the tube body, one end of the push plate is fixedly connected with a storage frame, and a storage rod is slidably connected into the storage frame. According to the portable medicine feeder for the mental patient, through the arrangement of the storage frame, the storage rod, a limiting sliding block and a limiting clamping block, when the portable medicine feeder is used, a user can manually push the storage rod, the storage rod moves to drive the limiting sliding block to slide in the storage frame, and after the storage rod is pushed to a certain position, the limiting clamping block can be clamped into a groove hole in the storage frame; the storage rod is fixed in the storage frame, so that the overall length of the device is adjusted, the effect of carrying the device is achieved, and the situation that when a user carries the device into a bag, articles in the bag are prone to squeezing the device, liquid medicine is prone to seeping, and subsequent normal medicine feeding is affected is avoided.

The utility model relates to the technical field of infusion apparatuses, in particular to an infusion apparatus with a filtering and dosing structure, which comprises an upper infusion tube, a filter cartridge, a lower infusion tube, a coarse filter layer, a fine filter layer, an ultrafiltration layer and a flushing component, the filter cartridge is connected with the upper infusion tube, the lower infusion tube is connected with the filter cartridge, the coarse filter layer is connected with the filter cartridge, the fine filter layer is connected with the coarse filter layer, and the ultrafiltration layer is connected with the flushing component. The ultra-filtration layer is connected with the fine filtration layer, the flushing component is arranged on the filter cartridge, the coarse filtration layer is used for intercepting large-particle impurities, the fine filtration layer is used for further filtering small particles, and finally, the ultra-filtration layer is made of a nano-scale filtration material, so that the purity of a liquid medicine solution is ensured; the filtered liquid medicine is input into a human body through the lower infusion tube and the connecting needle head, so that the influence of impurities in the liquid medicine on the human body is avoided.

Unit dosage forms, devices, and kits for topical delivery of topical immunosensitizers are provided. These include dermal patches, glass swabs, and kits containing a dermal patch and a glass swab. Among other advantages, the unit dosage forms, devices, and kits presented herein deliver a more consistent and controlled volume of drug solution, prevent underdosing and overdosing, prevent or discourage repeat dosing, and provide a more consistent skin area to which the drug solution is applied.

To provide a protective sheet which protects a puncture site without being directly attached to a user's body, allows easy visual confirmation of the state of the puncture site during protection, and can be quickly released in an emergency such as when a drug solution leaks or a needle comes out, and is easy to attach and detach. A protective sheet (1) for preventing accidental withdrawal of the needle during puncture is attached to the puncture site without being directly attached to the body of the user (5). The puncture site and the puncture needles 6a, 6b and tubes 7a, 7b connected to the puncture site are covered. and an adhesive portion 2 for fixing the protective sheet 1 in a wrapped state. , the adhesive portion 2 A non-porous part 3 that has no temper , the through hole adjacent to the non-perforated portion 3 and a perforated portion 4 having a temper. The adhesive portion 2 is provided only on one end of the protective sheet 1. The perforated portion 3 and the perforated portion 4 are not adhesive and are configured not to stick to the body of the user 5 during use.

This invention relates to the field of medical nebulizer technology, and more particularly to an automated nebulization therapy device and method, comprising a housing, a control system, and a power system. The housing contains a drug preparation chamber, a first nebulization chamber, a second nebulization chamber, and a water chamber. Through the installation of a distilled water pump, a water level monitoring system, a first electric valve, a drug solution level detection system, a drug solution mixing system, a drug solution mixing monitoring system, a second electric valve, and the nebulization system, automated control and nebulization of drug preparation and administration are achieved. This eliminates the need for manual drug preparation by medical personnel, avoiding the problem of poor treatment effects caused by uneven drug preparation and reducing the workload of medical staff. Simultaneously, the device can automatically clean itself, avoiding the impact on the treatment effect of the next patient due to inconsistent cleaning standards during manual cleaning. This solves the problems of high workload for manual drug preparation, poor nebulization effect, and low efficiency caused by uneven drug mixing in existing technologies.

This invention provides a continuous micro-dose delivery device and injection method, including a needle device, a drug storage device, a piston pusher device, a power storage device, a power release device, and a control device. Under the action of the control device, the power release device releases a specified piston stroke, and the power storage device pushes the piston pusher device to move a specified piston stroke into the drug storage device, through which the drug solution in the drug storage device is discharged via the needle device. Using the power storage device as a power source, the piston is driven by rotation or direct push. The required number of pulses is calculated based on the dosage to be infused or the distance the piston travels, and the control device precisely controls the power release device to release the specified piston stroke, thus improving the accuracy of the drug delivery dosage. A coupling assembly consisting of multiple gears connects the rotary magnetic brake assembly and the piston pusher device, enabling the rotary magnetic brake assembly to control a larger force from the power storage device with a smaller force.

The present application relates to a kind of methods for reducing the residue of liquid medicine filtering system, the filtering system includes filter valve body, inlet pipe, outlet pipe and exhaust pipe are connected to the filter valve body, first valve body is installed on the exhaust pipe, inlet pipe is connected to the outlet pipe, second valve body is arranged between the inlet pipe and filter valve body, third valve body is installed on the inlet pipe, discharge pipe is connected to the outlet pipe end, the outlet pipe is obliquely arranged, by sequentially opening and closing between each valve body, gas is discharged from the liquid medicine remaining in filter valve body, thereby effectively saving data, reduce production cost.

The invention provides a portable insulin atomization administration device which comprises an administration device body, a driving box is fixedly connected to the left end of the lower portion of the administration device body, a liquid storage box is fixedly connected to the right end of the lower portion of the administration device body, a motor is fixedly connected to the upper end of the inner side of the driving box, and a second gear is fixedly connected to the output end of the motor. The left end of the inner side of the driving box penetrates through the drug delivery device body to be rotationally connected with a rotating shaft, and the bottom of the rotating shaft is fixedly connected with a gear I. According to the drug delivery device, a motor drives a gear system to drive a piston to do reciprocating motion, and efficient atomization of liquid medicine is achieved by combining the dual effects of a Venturi acceleration ring and a conical splitter plate; the Venturi structure accelerates shearing of liquid medicine in the spray head, the splitter plate further impacts and disperses the liquid medicine into ultrafine particles, atomization uniformity and inhalation efficiency are remarkably improved, meanwhile, the design that the rotating speed of the motor is adjustable meets the individualized dosing requirement, pain caused by traditional injection is avoided through mechanical precise control, and insulin absorption is faster and more stable.

The invention provides a multi-dimensional electronic regulation and control microneedle injection medicine introduction system, and belongs to the technical field of medical instruments. The system comprises a shell, a user interaction module, a control and drive module, a drive execution module and a microneedle module integrated with an adjustment protection device. The user interaction module is used for realizing multi-parameter collaborative setting and real-time display of injection pressure, dose and speed through a display screen and a control key; the control and driving module generates a regulation and control instruction according to the set parameters; the driving execution module accurately controls liquid medicine conveying according to the instruction; an adjusting protection device of the microneedle module can control the penetration depth of the microneedle and provide protection when the microneedle module is not used. By means of electronic integrated control, multi-dimensional, quantifiable and self-adaptive precise regulation and control of the drug introduction process are achieved, the safety, effectiveness and operation convenience of injection are effectively improved, and the system is suitable for various drug administration scenes such as clinic and families.

The invention relates to the technical field of vibration mixing containers, in particular to mixing equipment for medicine processing based on vibration shaking up. The device comprises an oscillation table and an oscillation container, the oscillation container is detachably connected to the top of the oscillation table, a liquid level adjusting mechanism extending longitudinally is coaxially arranged in the oscillation container, and a junction turbulent flow mechanism is further arranged in the oscillation container. According to the device, the turbulent flow ring can be matched with junctions of liquid medicine with different proportions through the liquid level adjusting mechanism, the turbulent flow ring is driven to conduct three-dimensional annular vibration in cooperation with the elastic telescopic assembly, and multidirectional liquid medicine exchange on the upper side, the lower side, the inner side and the outer side of the turbulent flow ring is achieved based on the mass flow conservation principle; the vibrating rod and the turbulent flow blade arranged in the turbulent flow ring generate irregular vibration and rotation under the multi-directional impact of the liquid medicine, and the interface of the two kinds of liquid medicine is damaged by shearing, so that the mixing speed of the device is increased, and the mixing effect of the device is improved.

The invention discloses an injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) respectively dissolving Gelma and HAMA in sterile PBS (Phosphate Buffer Solution) according to the dosage required by a final system; 2) mixing the two solutions, and adding a photoinitiator LAP pre-dissolved in the sterile PBS at 60 DEG C; 3) dissolving golden larch bark acetic acid in dimethyl sulfoxide to prepare a medicine solution with the concentration of 1.0 mg / mL, and then adding the medicine solution into the precursor solution under the condition of continuous stirring; and 4) carrying out 405 nm illumination crosslinking on the obtained precursor solution to form the hydrogel. The hydrogel three-dimensional network can continuously and controllably release pseudolaric acid, maintains a long-acting effective drug concentration at an infected part, shows a strong inhibition effect on a candida albicans standard strain and a clinical drug-resistant strain, and has a good application prospect in a model for treating candida vaginitis and fungal skin wound infection. And all the components show a remarkable'anti-infection-repair promoting 'integrated treatment effect.

The present invention provides a drug solution bottle unit having a structure capable of reducing the amount of force required to press the tray when opening the respective lid members of two drug solution bottles. To this end, a drug solution bottle unit 10 according to the present invention comprises: a first bottle 11 having an interior sealed by a first lid 17; and a second bottle 12 having an interior sealed by a second lid 18. The first lid is provided on a first end face 11a of the first bottle, and the second lid is provided on a first end face 12a of the second bottle. The first lid and the second lid are arranged at positions differing in distance from respective second end faces 11b and 12b of the first bottle and the second bottle. The first bottle has a first region 13 for filling liquid, and the second bottle has a second region 14 for filling liquid. The second region includes a first accommodation portion and a protrusion 12d that communicates with the first accommodation portion to form the second region.