315 results about "Drugs solution" patented technology

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The present application discloses an ultra-high-speed jet drug delivery device, which relates to the field of drug delivery technology and includes: a jet parameter setting module for determining the direction and speed of the jet according to the drug delivery requirements; a high-energy current module for generating high-energy current to make the metal wire reach a high-temperature state instantly, driving the drug solution to form a high-speed fluid; a nozzle for converting the high-speed fluid into a jet according to the direction and speed of the jet determined by the jet parameter setting module; a sensor module for monitoring the distribution of the drug solution in the body in real time; and a precision delivery module for controlling the jet parameter setting module in real time to adjust the direction and speed of the jet according to the distribution of the drug solution in the body and the drug delivery requirements. In the present application, electric explosion technology is used to form a high-speed jet, providing powerful kinetic energy to effectively penetrate human tissue, achieve precise drug delivery to deep target areas, and combine with sensors to ensure that the drug jet is accurately delivered to deep tissues.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention relates to the technical field of biological medicine, in particular to a medicine solution composition, a preparation method thereof and a nasal spray. The pharmaceutical composition comprises active pharmaceutical ingredients, a pH regulator, an osmotic pressure regulator and water, the active pharmaceutical ingredient is rizatriptan or a salt thereof; the pH regulator is used for regulating the pH of the pharmaceutical composition to 4.0-7.0; and the osmotic pressure regulator is used for regulating the osmotic pressure of the pharmaceutical composition to 280-350mOsm / kg. The nasal spray can be used for rapidly relieving migraine in the acute stage, rapid analgesia is achieved, the drug stability is good, the nasal spray is not affected by food, the components are simple and effective, and the nasal spray has commercial production value.

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L / min to 60 L / min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL / hour and 50 mL / hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

A fluid delivery device for an eye is provided. The fluid delivery device includes a first component; a second component connected to the first component and forming a fluid-tight chamber with the first component, the chamber being adapted to contain a drug solution to be delivered; the plurality of microneedles are arranged on the first part in a penetrating manner, and the microneedles are arranged to establish a fluid delivery channel which is in fluid communication with the cavity between the first part and the to-be-treated part of the eye when the first part is attached to the eye of the subject; the gas release layer is located in the cavity, and the gas release layer is arranged to release gas into the cavity. The fluid delivery device not only can deliver a drug solution, but also can deliver environment gas expected by treatment, and is simple to operate and convenient to dispose after being used.

The utility model discloses a biopharmaceutical sampler which comprises a sampling barrel, a push rod, a sealing plug, a sampling opening, a measuring scale, a protective cover, a sealing mechanism, a filter layer, a cleaning brush, scale marks, an exhaust valve and a fixing ring, the biopharmaceutical sampling device is reasonable and simple in structure, low in production cost, convenient to install and complete in function, the biopharmaceutical sampling amount can be accurately controlled through the arranged measuring scale and scale marks, and the accuracy of experimental data is improved; impurities in liquid medicine are effectively filtered through the filter layer, the purity of sampling is ensured, and the accuracy of follow-up detection and analysis is facilitated; the inner wall of the sampling barrel is convenient to clean through the cleaning brush, cross contamination among different samples is avoided, and independence and accuracy of sampling each time are guaranteed.

The invention relates to the technical field of extracellular vesicles, in particular to an extracellular vesicle active drug loading method which comprises the following preparation steps: S1, collecting cell supernatant, collecting the cell supernatant under the condition of 4 DEG C, and performing multi-stage centrifugation to remove impurities to obtain purified extracellular vesicles; s2, dissolving a target drug in a corresponding solvent to prepare a drug solution with the concentration of 0.1-5 mg / mL; s3, mixing the purified extracellular vesicles obtained in S1 with the medicine solution obtained in S2 according to the volume ratio of 1: 1, and performing low-frequency ultrasonic treatment in a pulse mode under the ice bath condition of 4 DEG C; s4, incubating the mixed system subjected to ultrasonic treatment at 37 DEG C for 25-35 minutes, and meanwhile, adding a cholesterol solution with the final concentration of 0.005-0.01% to assist membrane repair; the problems of contradiction between the drug loading efficiency and the integrity of the extracellular vesicles, poor drug universality, low purification efficiency and insufficient application stability in the existing active drug loading technology of the extracellular vesicles are specifically solved through the whole process optimization of precise purification, efficient drug loading, directional repair and deep refining.

The present invention relates to the technical field of pharmaceutical analysis, and specifically provides a method and system for detecting the components of drugs based on basic pharmacy, including the following steps: Based on the detected drug sample, measure the weight of the drug sample, add a solvent for dissolution according to a preset ratio, combine dilution and mixing, record the color, viscosity, and pH value of the solution, and generate a standardized sample solvent. In the present invention, by standardizing the drug sample, the measurement baseline is ensured, the result deviation is reduced, the credibility of the data is improved, the changes in particle size and quantity are monitored in real time, the understanding of the dissolution process is enhanced, the impedance change of the drug solution is evaluated by monitoring the current response at multiple frequencies, the analysis of electrochemical properties is strengthened, impurities are accurately detected, the chemical properties data of the drug are provided by combining the determination of spectral absorption and fluorescence characteristics, the composition components of the target drug are identified, the drug formula is ensured to meet the specified standards, and the safety and effectiveness of the drug are guaranteed.

The invention discloses a pH response hydrogel microneedle, which comprises a microneedle substrate, microneedle tips are arranged on the microneedle substrate, the height of the microneedle tips is 100-1600 microns, the diameter of the tip ends of the microneedle tips is 5-15 microns, and the density of the microneedle tips is 200-1000 pieces per square centimeter. The preparation method comprises the following steps: preparing a hyaluronic acid solution for the microneedle substrate, preparing a methacrylated chondroitin sulfate solution for the microneedle tip, preparing methacrylated orthoester, preparing orthoester, preparing a non-steroidal anti-inflammatory drug solution, preparing a microneedle tip solution, preparing the microneedle and demolding the microneedle to prepare the complete soluble microneedle patch. The invention has the advantages of high drug efficiency, high efficiency in dissolving fat / water drugs, and long-acting slow release.

The present application provides a compound for preparing an embolization bead, a hydrogel bead, a preparation method therefor and a use thereof, the compound having a structure as shown in formula I. A hydrogel bead capable of carrying a chemical drug has a core-shell structure, comprising a shell formed from the compound, and a core formed from an ionic monomer polymeric segment. A hydrogel bead capable of carrying a protein has a core-shell structure, comprising a shell formed from the compound, and a core formed from a zwitterionic polymeric segment. The compound of the present application has good stability, which makes it possible to improve the stability of a hydrogel bead when the compound is used to prepare the hydrogel bead. The hydrogel beads of the present application have a super-hydrophilic core-shell structure, and the dense shell layer and high hydrophilicity cause the beads to have strong toughness, and not break when swelling. Dry beads of the hydrogel beads can quickly adsorb a drug solution, achieving high-efficiency, rapid and high-load drug loading, with significant sustained release effects for drugs or proteins, which can effectively regulate drug release.

The invention provides a drug detection method and device and a computer storage medium, the drug detection method comprises the steps that a blank terahertz chip and a sample terahertz chip are obtained, and the terahertz chip comprises a substrate and a metamaterial growing on the substrate; obtaining a terahertz reference time domain signal of the blank terahertz chip and obtaining a terahertz sample time domain signal of the sample terahertz chip; performing Fourier transform on the terahertz reference time domain signal to obtain a terahertz reference frequency domain spectrum signal; performing Fourier transform on the terahertz sample time domain signal to obtain a terahertz sample frequency domain spectrum signal; comparing the terahertz reference frequency domain spectrum signal with the terahertz sample frequency domain spectrum signal to obtain harmonic peak offset; and determining the drug solution concentration of the sample based on the harmonic peak offset. In this way, rapid qualitative and quantitative detection of the liquid drug solution can be achieved, and the method is easy to operate, small in sample sampling amount and easy to operate.

The invention discloses a novel administration method for eye administration. The novel administration method specifically comprises the following steps: S1, filling a special solution bottle with a drug solution; s2, the solution bottle is aligned with the eyes to be used in the spraying process, medicine fog drops enter the eye liquid medicine bottle to be combined with an atomization device to be used, fine fog-shaped liquid drops are sprayed out through the atomization device, the particle size of the fog drops ranges from 0.1 micrometer to 60 micrometers, and the fog drops reach eyeballs and the peripheries of the eyes; s3, administration is performed in a medicine and mechanical combination mode during use, the medicine solution and the atomization device can be separately produced and prepared, and the medicine solution and the atomization device are combined during use. According to the novel administration method and atomization administration mode for eye administration, the medication treatment effect can be improved, the risk of eye infection caused by drugs is reduced, the discomfort of eyes during medication is improved, and the medication compliance of patients is improved.

The invention discloses an intelligent drug delivery and release system based on a micro-fluidic technology, which comprises a micro-fluidic chip, a fluid chip used for accurately controlling and analyzing a micro volume, a micro-machined channel and a micro-machined cavity, a liquid medicine storage device used for mixing, separating, reacting and detecting fluids on a micro scale, a liquid medicine storage device used for storing and managing drugs and a liquid medicine release device used for releasing the drugs. A micro-cavity is arranged in the body, a total liquid storage device and a fluid control module are arranged on the outer side of the body and used for accurately controlling the flowing and releasing speed of a medicine solution, and a monitoring sensor is used for monitoring concentration indexes of medicine in the body of a patient in real time and used for monitoring physiological parameters and medicine concentration; the micro-fluidic chip, the liquid medicine storage device, the fluid control module, the monitoring sensor, the control module, the power supply module and the connecting pipeline are matched for use, the liquid medicine storage device and the fluid control module obtain the medicine concentration, the release amount and the conveying rate of the medicine are calculated, and it can be guaranteed that the medicine concentration of a diseased area is stable.

The invention discloses radiopharmaceutical split charging equipment and a split charging method. The equipment comprises an upper shell and a lower shell, a base used for containing a stock solution bottle distribution tank is arranged at the bottom of the lower shell, a cover opening mechanism used for opening a tank cover of the stock solution bottle distribution tank and a needling mechanism used for extracting stock solution in a stock solution bottle are arranged above the base, and a horizontal sliding mechanism is arranged at the bottom of the base. The driving mechanism is used for driving the base to slide to the position under the uncovering mechanism and the needling mechanism. A stock solution extracting needle is fixed to the needling mechanism and used for extracting stock solution in a stock solution bottle and then transferring the stock solution into a liquid medicine diluting bottle in the upper shell, and then split charging is achieved through a liquid medicine split charging and transferring guide pipe in the upper shell. Opening of a stock solution bottle distribution tank and extraction of stock solution in a stock solution bottle can be sequentially achieved in the lower shell through the uncovering mechanism and the needling mechanism, the stock solution distribution tank and the stock solution in the stock solution bottle can be matched with a liquid medicine subpackaging and transferring guide pipe in the upper shell, all-directional protection subpackaging is achieved, the protection effect in the whole process is good, and harm to medical staff is greatly reduced.

The utility model discloses an anti-seepage microneedle patch which comprises a base and an anti-seepage microneedle arranged on the base. In the direction away from the substrate, the anti-seepage microneedle comprises a dissolution layer, an anti-seepage layer and a medicine carrying layer; in the direction parallel to the substrate, the maximum size of the impermeable layer is larger than the maximum size of the medicine carrying layer, and the maximum size of the impermeable layer is larger than the minimum size of the dissolution layer; the dissolving speed of the drug carrying layer is V1, the dissolving speed of the impermeable layer is V2, and the dissolving speed of the dissolving layer is V3, V1gt; v2, V3gt; v2; according to the technical scheme, quantitative dosing is achieved, and meanwhile exosmosis of a medicine solution is avoided.

An information management system (10) comprises a drug solution administration device (12) and an information management device (14). The drug solution administration device comprises a transmission control unit (104) that transmits information acquired using a sensor (86) provided to the drug solution administration device to the information management device. The information management device comprises a reception control unit (124) that receives the information transmitted by the transmission control unit and a determination unit (128) that, on the basis of the information received by the reception control unit, determines whether a drug solution administration amount has reached a predetermined required administration amount.

The invention relates to the technical field of atomizers, in particular to an intelligent atomization control system for medicine dosage homogenization, which comprises a temperature feedback control module, a laser granularity measurement module, an airflow fluctuation compensation module, a flow regulation module and a data analysis module. By intelligently controlling the flow, granularity, airflow and temperature of liquid medicine, accurate adjustment of the atomization process can be achieved, it is ensured that medicine is evenly and stably released in the whole treatment process, waste of the liquid medicine is remarkably reduced, the medicine utilization rate is increased, and by monitoring the temperature change in real time, the atomization effect is improved. The flow is adjusted to cope with the influence of temperature fluctuation on the liquid medicine flow characteristic and the atomization effect, medicine conveying stability in different environments is guaranteed, meanwhile, based on particle size control, airflow and flow can be adjusted in time to guarantee consistency of atomized particles, uneven medicine dosage caused by particle size fluctuation is avoided, and through airflow fluctuation compensation, the atomization effect is improved. It can be ensured that the influence on medicine flow is minimized when airflow is unstable, and dosage instability is avoided.

An intermediate assembly (Sa) of a drug solution administration device (10) is provided with a first unit (U1) and a second unit (U2) attached to the first unit (U1). The first unit (U1) has a hollow cylindrical housing (12). The second unit (U2) has a drive unit (D) and is attached to a fixing part (27) of the housing (12) of the first unit (U1). In a state in which a syringe (16) is not accommodated inside the first unit (U1), the second unit (U2) is provisionally fixed to the fixing part (27) of the first unit (U1). In a state in which the second unit (U2) is removed from the first unit (U1) and the provisional fixed state is disengaged, and in which the syringe (16) is accommodated inside the housing (12) of the first unit (U1), the second unit (U2) and the first unit (U1) can be formally fixed.

A pyridine amide compound-containing composition and a pharmaceutical composition, a preparation method therefor and a use thereof. The composition comprises an active ingredient and at least one matrix material, wherein the active ingredient is a compound represented by formula I or a pharmaceutically acceptable salt, a stereoisomer, a solvate, an isotopically labeled compound, a polymorph, a metabolite or a prodrug thereof. The composition has a high drug loading capacity, improves drug solubility, and has good stability. The in vivo bioavailability of the composition can reach the same level of bioavailability as that of a clear drug solution.

Provided is a drug solution administration device (1) for administering a drug solution filled in a reservoir (18), the drug solution administration device (1) comprising a pump body (10) provided with: a pump for transporting the drug solution filled in the reservoir (18); a rechargeable battery (42) for supplying power for driving the pump; a measurement unit (76) for measuring the remaining charge of the rechargeable battery (42); and a control unit (71). If the remaining charge of the rechargeable battery (42) measured by the measurement unit (76) is greater than a predetermined threshold value, the control unit (71) notifies a user that the rechargeable battery (42) is fully charged.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The invention discloses a coating preparation method capable of regulating and controlling the morphology of a coating. The coating preparation method is used for spraying on an instrument. A drug solution used in the preparation method of the coating comprises at least one solvent, a drug active ingredient and an excipient in a preset proportion are added into the solvent, when only one solvent is used, the solvent is a polar and high-volatility solvent A, stirring and ultrasonic oscillation are carried out at room temperature so as to uniformly dissolve the solvent A, and the drug solution is obtained, when the medicine solution is sprayed, the spraying flow and the moving speed of a spray head are adjusted through external spraying equipment according to a preset standard so as to spray at least one layer of medicine solution on an external instrument, and therefore the preset coating morphology is formed on the surface of the instrument through the medicine. The method has the advantages that the microstructure of the coating can be controlled to improve the stability of the coating; therefore, the release effect of the medicine is ensured, and the release behavior and the tissue retention time of the medicine in various lumen stenosis diseases can meet the delivery requirements required by clinical treatment.

The invention relates to the technical field of medicine analysis, in particular to a medicine component detection method and system based on basic pharmacy, and the method comprises the following steps: detecting a medicine sample, measuring the weight of the medicine sample, adding a solvent according to a preset proportion for dissolving, combining dilution and mixing, and recording the color, viscosity and ph value of the solution, and generating a standardized sample solvent. According to the invention, standardization processing is carried out on a drug sample, a measurement base line is ensured, result deviation is reduced, data credibility is improved, particle size and quantity changes are monitored in real time, understanding of a dissolution process is improved, and analysis of electrochemical properties is enhanced by monitoring current response and evaluating impedance changes of a drug solution under various frequencies. Impurities are accurately detected, spectral absorption and fluorescence characteristic determination are combined, chemical characteristic data of drugs are provided, components of target drugs are recognized, it is ensured that the formula of the drugs meets the specified standard, and the safety and effectiveness of the drugs are guaranteed.

This invention discloses a multi-stage dosing device and method for a concentrated liquid flocculation tank, relating to the technical field of dosing equipment. It includes: a fixed frame, disposed on the top of the tank, with a track rod fixedly connected to the end of the fixed frame, and a housing slidably connected to the track rod; a ring-shaped airbag fixedly connected to the top edge of the housing; a dosing device, arranged in a circumferential array on the housing, comprising: a ring pipe, with a delivery pipe circumferentially connected to the ring pipe, one end of the delivery pipe connected to the ring pipe and the other end fixedly connected to the housing and extending into the tank; an inlet device for supplying the drug solution to the ring pipe; and a slow-release device, arranged in a circumferential array on the housing, with an opening and closing device on the housing for adjusting the drug output of the slow-release device.

The invention provides a special lung atomization therapeutic apparatus for the internal medicine of traditional Chinese medicine, and relates to the technical field of medical instruments, the special lung atomization therapeutic apparatus comprises an atomizer body, an atomization tank, a mist discharging pipe and a connecting pipe, the connecting pipe is inserted into a connecting plug at the bottom end of the atomization tank, and the other end of the connecting pipe is inserted into the air outlet end of the atomizer body; the double-cavity isolation type atomization tank is adopted, and aiming at the scene that salbutamol sulfate, budesonide and the like are compatible but need to be dosed for several times, through the design of the upper-layer independent medicine storage cavity, the lower-layer independent medicine storage cavity and the isolation gas circuit, the medicine can be dosed for several times, and the medicine can be dosed for several times. After the first liquid medicine is atomized, treatment is not required to be interrupted to replace a container or detach an air pipe, and the second medicine can be quickly switched only by cleaning the mask, so that the problems of tedious operation and treatment interruption of fractional atomization of a single medicine tank are solved, and tiny physical and chemical influence possibly caused by advanced mixing of a large amount of liquid medicine is avoided; and meanwhile, the operation time in the emergency scene is remarkably shortened.

The invention belongs to the technical field of medicines, and discloses a betahistine mesylate oral soluble film agent for treating meniere disease, meniere syndrome and vertigo symptoms caused by vertigo and a preparation process thereof, the preparation process comprises the following steps: (1) adding betahistine mesylate into purified water; (2) adding glycerol, citric acid, sucralose, liquid orange-flavored essence and sunset yellow into the raw material medicine solution; (3) taking HPMC-E15, dispersing the HPMC-E15 in purified water, and adding HPC-LXF for thickening; (4) adding the medicine-containing solution into the blank glue solution; (5) degassing; (6) coating; and (7) cutting and packaging. Compared with a common tablet, the oral soluble film disclosed by the invention has a higher release rate, and can enter a body through a sublingual vein way in addition to a conventional gastrointestinal tract absorption way after being dissolved in an oral cavity, so that the bioavailability is increased; under the condition of stability acceleration, the compound has a better impurity level, and the preparation process is simple to operate, high in repeatability and suitable for industrial large-scale production.

The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation process of crotamiton and an external preparation applied by the crotamiton. Comprising the following steps: step 1, slowly dropwise adding 2-butenoyl chloride into N-ethyl-o-toluidine, and controlling the reaction temperature at 10-30 DEG C; after the reaction is finished, heating to 45-55 DEG C, and reacting for 2-4 hours to obtain a product A; adding purified water for dilution, adding a demulsifier, and adding ethyl acetate for extraction to obtain an organic phase; 2, washing the organic phase with a hydrochloric acid solution and a sodium hydroxide solution in sequence, performing liquid separation, performing reduced pressure distillation, collecting fractions at the temperature of 152-155 DEG C and the pressure of-0.096 to-0.1 Mpa, performing refined filtration with a 0.2-0.24 [mu] m filter element in sequence, performing filling, performing capping, and performing packaging; and thus, the crotamiton is obtained. And preparing a medicine solution from crotamiton and other substances, and combining the medicine solution with the pre-gel solution to obtain the external preparation of crotamiton.

The invention provides a composition of 14 amino acids and glucose stored in a double-chamber bag and a preparation method of the composition. The composition of 14 amino acids and glucose stored in the double-chamber bag does not contain sulfite antioxidants and metal ion chelating agents. The preparation method comprises the following steps: pretreating production equipment by adopting a pretreatment solution containing inorganic acid, organic acid and ammonium salt, and then preparing liquid medicine, filtering, making bags, filling, sealing outer bags, sterilizing and the like. Double-chamber bag packaging is adopted, so that the Maillard reaction of amino acid and glucose in the production and storage process can be avoided, meanwhile, the aluminum migration risk in the packaging material is reduced, and the clinical medication safety and effectiveness of the product are improved. During clinical use, liquid medicine in the two cavities is mixed through extrusion, the bioavailability of all the components can be synergistically improved, meanwhile, osmotic pressure is reduced, and clinical infusion compliance is improved.

The invention relates to a preparation method of a tranexamic acid hydrogel microneedle. The preparation method comprises the following steps: 1) preparing a PDMS microneedle female template; 2) preparing a blank hydrogel microneedle; 3) preparation of the drug-containing hydrogel microneedle: dissolving tranexamic acid and derivatives or analogues thereof in ultrapure water, with the content range of the tranexamic acid and derivatives or analogues thereof being 0.1-30 mg / tablet, and preparing a drug solution with the mass concentration of the tranexamic acid and derivatives or analogues thereof being 0.1 g / mL, and (3) uniformly pouring the medicine solution into the blank hydrogel microneedle mold prepared in the step (2), then drying and forming at 37 DEG C, and finally, demolding the dried microneedle from the mold to obtain the tranexamic acid hydrogel microneedle. According to the tranexamic acid hydrogel microneedle, tranexamic acid can directly reach a skin basal layer, the tranexamic acid hydrogel microneedle can load and deliver more tranexamic acid, the treatment effect is remarkably enhanced, long-time slow release is achieved, and the tranexamic acid hydrogel microneedle has remarkable social and economic benefits.