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6521results about How to "Prevent precipitation" patented technology

Porous drug matrices and methods of manufacture thereof

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid-compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
Owner:ACUSPHERE INC

Porous drug matrices and methods of manufacture thereof

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.
Owner:ACUSPHERE INC

Solar water evaporation purification and decomposition device

The invention discloses a solar water evaporation purification and decomposition device which comprises a water supply line, a float and heat insulation layer, an evaporation layer and a photothermalconversion and solute barrier layer which are connected in sequence from bottom to top. The water supply line enables water to pass through the float and heat insulation layer, and the water is pumpedinto the evaporation layer by virtue of a capillary action; solar energy absorbed by the photothermal conversion and solute barrier layer is converted into heat, and water is heated to be vaporized into water vapor from the evaporation layer; due to pore channel volatilization of the photothermal conversion and solute barrier layer, partial water vapor is decomposed to produce hydrogen and oxygen; since the photothermal conversion and solute barrier layer contains a hydrophobic part and is not infiltrated by water, the solar energy can directly heat a heat-absorbing material only, but not heat water, so that high photothermal conversion efficiency is realized; and meanwhile, the solute in the water is prevented from being separated out on the membrane, and sea water desalination, sewage purification and water decomposition can be realized. Due to the design of a hydrophilic/hydrophobic double-layer evaporation structure, the solar water evaporation purification and decomposition device with high photothermal conversion efficiency and high stability is obtained.
Owner:XI AN JIAOTONG UNIV

High-strength, high-toughness and high-plasticity martensitic stainless steel and preparation method thereof

ActiveCN103614649AImprove the level of toughness and plasticityImprove stabilityMartensitic stainless steelRoom temperature
The invention discloses high-strength, high-toughness and high-plasticity martensitic stainless steel, and belongs to the technical field of metallurgy. The martensitic stainless steel comprises the following components in percentage by weight: 0.15 to 0.4 percent of C, 0 to 0.12 percent of N, 0.2 to 2.5 percent of Si, 0.4 to 3.0 percent of Mn, less than or equal to 0.02 percent of S, less than or equal to 0.02 percent of P, 13.0 to 17.0 percent of Cr, 0 to 5.0 percent of Ni, 0 to 2.0 percent of Mo, 0 to 0.3 percent of V, 0 to 0.2 percent of Nb, 0 to 0.05 percent of Ti, 0 to 0.8 percent of Al and the balance of Fe and inevitable impurities. A preparation method comprises the following steps of (1) smelting molten steel according to the set components, and solidifying the molten steel to form an ingot blank by using a continuous casting machine or a casting mold; (2) hot-rolling the ingot blank to form a hot-rolled plate blank; (3) heating the hot-rolled plate blank to 950 to 1100 DEG C, preserving heat for 0.5 to 2 hours, cooling the plate blank to 25 to 200 DEG C, heating the plate blank to 350 to 500 DEG C, preserving heat for 10 to 60 minutes, and air-cooling the plate blank to room temperature. According to the martensitic stainless steel prepared by the method, dispersed remaining martensite is introduced into a microscopic structure, so that the strength, toughness and plasticity of the martensitic stainless steel are greatly improved.
Owner:NORTHEASTERN UNIV

Composite porous current collector, and preparation method and application thereof

The invention provides a composite porous current collector, and a preparation method and an application thereof. The composite porous current collector comprises a porous electron conducting layer with through holes and an electron insulating layer with through holes, wherein the porosity of the through holes of porous electron conducting layer is not less than the porosity of the through holes of the electron insulating layer, a position of the porous electron conducting layer corresponding to the position of the through hole of the electron insulating layer is a through hole, and a position of the porous electron conducting layer corresponding to the position of the non-through hole of the electron insulating layer can be a through hole, and also can be a blind hole or a rough surface. The electron insulating layer is adjacent to an isolation layer, so puncture of precipitated lithium dendrite to a diaphragm is prevented, direct contact of the electron conducting layer is avoided, and the safety of a battery is improved; the above corresponding through hole structure is in favor of transferring lithium ions, so the internal resistance of the battery is reduced; the hole structure of the porous electron conducting layer and the homogeneous rough surface are in favor of full contact of an electrode active substance with the current collector, the current is uniformly distributed, and the current collection effect is improved; and the preparation method adopting airflow punching has the advantages of simplicity, easy implementation, cleanness, energy saving, combination of other various enforcement modes, and convenience for production and application.
Owner:南京竞予能源有限公司
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