The invention relates to an herbicide composition containing clacyfos. The 100% of herbicide composition comprises an ingredient A, one or more of an ingredient B and the balance, wherein the ingredient A is the clacyfos, the ingredient B is selected from one or more effective ingredients including flucarbazone, pyraflufen-ethyl, florasulam, flumetsulam, pyroxsulam, 2,4-D butyl ester, fenoxaprop-p-ethyl, barban, bensulfuron-methyl, pinoxaden, chlortoluron, thifensulfuron, mesosulfuron or sodium metsulfuron methyl iodide, and the balance includes a dispersing agent, a wetting agent, a stabilizing agent, a thickening agent and a solvent. The weight ratio of the ingredient A to the ingredient B is 1:160-160:1. Two groups of active substance can be compounded to effectively prevent and control annual or perennial broadleaf gramineous weeds in wheat fields. The herbicide composition can improve preventive effects of simple dosages and enlarge weeding spectrum and is safe to wheat.