135results about How to "High dissolution rate" patented technology

The invention discloses pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles as well as preparation and application thereof, and relates to the technical field of pharmaceutical preparations. Inspired by compatibility and solubilization of traditional Chinese medicines, the pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles (AB4-OA NPs) are prepared by taking natural active components, namely micromolecular pulsatilla saponin B4 and oleanolic acid, as raw materials; the oleanolic acid has the effects of promoting dissolution and resisting inflammation, the water solubility of the oleanolic acid is improved, the bioavailability is improved, and the anti-inflammatory effect of the oleanolic acid is enhanced. Experimental results show that the AB4-OA NPs can effectively improve the dissolution rate of the oleanolic acid, so that the bioavailability of the oleanolic acid is effectively improved, meanwhile, the AB4-OA NPs has a better anti-inflammatory effect, and the effect is better than that of a single drug with the same dosage. In addition, the synthetic preparation method is simple and convenient, has the advantages of nano-scale drugs, realizes auxiliary-material-free pure drug self-delivery, and improves the delivery efficiency.

The invention relates to a radix scutellariae self-assembled nanoparticle and terbinafine co-loaded nanoparticle as well as a preparation method and application thereof, and belongs to the technical field of drug nanoparticles. The preparation method comprises the following two steps: preparing scutellaria baicalensis self-assembled nanoparticles, and preparing the scutellaria baicalensis self-assembled nanoparticles and terbinafine co-loaded nanoparticles. The co-loaded nanoparticles are prepared by the preparation method. The invention also discloses application of the co-loaded nanoparticles in treatment of dermatophytosis. The invention has the following advantages: the saturation solubility of baicalin (BCN) and terbinafine (TBF) is increased; the dissolution rate of the terbinafine (TBF) is obviously improved; the antibacterial effect of the TBF is improved; hypha growth, biomass generation and spore germination of three kinds of trichophyton of trichophyton rubrum, trichophyton mentagrophytes and microsporum canis can be inhibited.

The invention belongs to the technical field of resource recycling, and discloses lead-zinc tailing ceramsite and a preparation method thereof. The lead-zinc tailing ceramsite is mainly prepared from the following raw materials in parts by mass: 100 parts of lead-zinc tailings; 20 to 30 parts of limestone tailings; 6-8 parts of active mullite nano powder; 1-3 parts of glass micro powder; and 8-12 parts of dry sludge powder. The invention also provides a preparation method of the lead-zinc tailing ceramsite. The lead-zinc tailings are used as main raw materials to prepare the lead-zinc tailings ceramsite, through compounding of the lead-zinc tailings and the limestone tailings, the synergistic effect of the lead-zinc tailings and the limestone tailings is achieved, resource utilization of the lead-zinc tailings and the limestone tailings is achieved, and good economic benefits and social benefits are achieved. The density grade of the ceramsite prepared by the invention is 600-900, the cylinder compressive strength is 6.8-9.8 MPa, the water absorption rate is 9.4-11.4%, and the ceramsite has relatively good strength and relatively low water absorption rate.

The invention discloses a pharmaceutical preparation of a protein kinase inhibitor citrate as well as a preparation method and application of the pharmaceutical preparation. The pharmaceutical preparation comprises citrate of a protein kinase CDK4 / 6 inhibitor and auxiliary materials including a filler, a disintegrating agent, an adhesive, a wetting agent, a glidant and a lubricant. The protein kinase inhibitor citrate pharmaceutical preparation has the advantages of being good in quality, high in stability, high in dissolution rate, simple in preparation method, controllable in quality and the like.

The invention relates to a pharmaceutical composition of a compound shown in a formula (I) or a salt thereof, a preparation and a preparation method thereof. Specifically, the invention discloses a pharmaceutical composition taking a compound as shown in a formula (I) or pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition contains a compound as shown in a formula (I) or pharmaceutically acceptable salts thereof and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition provided by the invention has good pharmaceutical stability and safety, and the preparation method is simple and convenient and is suitable for industrial production. # imgabs0 #

The present invention belongs to the field of medical technology related to the extraction and application of natural drug components, discloses a white peony extract for treating hyperuricemia, a preparation method thereof and an application thereof, and provides a preparation method of a white peony extract for treating hyperuricemia, wherein the obtained white peony extract has a good therapeutic effect on a hyperuricemia animal model; mainly inhibiting uric acid production by inhibiting the activity of xanthine oxidase in serum and liver, while downregulating the levels of renal tissue proteins URAT1 and GLUT9, and upregulating the levels of renal tissue proteins OAT1 and OAT3 to reduce uric acid reabsorption and promote uric acid excretion, thereby achieving the purpose of reducing uric acid levels. Furthermore, the white peony extract is synergistically used with the currently commonly used uric acid-lowering drug allopurinol to develop a more effective and safe uric acid-lowering treatment plan.

The invention provides a pharmaceutical composition containing fenerenone, which comprises the following components in percentage by weight: 1.0%-30.0% of fenerenone, 1.0%-5.0% of hydroxypropyl methylcellulose, 0.1%-1.0% of lauryl sodium sulfate, 5.0%-15.0% of polyvinylpolypyrrolidone and 0.5%-5.0% of sodium stearyl fumarate. The filler is microcrystalline cellulose and lactose monohydrate, a wet granulation process is adopted, the pharmaceutical composition has the characteristics of stable and rapid dissolution and rapid disintegration of the fenerenone, the process is simple, the production steps are simplified, the production efficiency is improved, and the cost is reduced.

The invention discloses a coenzyme Q10 phospholipid-cyclodextrin double-layer inclusion compound and a preparation method thereof, and particularly relates to the technical field of food raw materials. A preparation form of double-layer inclusion of phospholipid on the inner layer and cyclodextrin on the outer layer is adopted, so that the solubility and bioavailability of the coenzyme Q10 are remarkably improved, and good stability is shown. Meanwhile, the preparation process is simple, the used organic solvent is relatively safe and single, and the method is suitable for industrial mass production.

The invention belongs to the technical field of medicines, and particularly relates to a flavonoid compound-meglumine co-amorphous substance and a preparation method thereof. The flavonoid compounds comprise baicalein, hesperetin, naringenin, kaempferol, quercetin, isoliquiritigenin and the like, and the co-amorphous substance consists of a single flavonoid compound and meglumine and is prepared by adopting a melting shock cooling method or a rotary evaporation method. The miscibility of the flavonoid compounds and the meglumine is screened through Hansen solubility. The crystal diffraction characteristics, thermodynamic properties and intermolecular interaction of the co-amorphous substance are measured through PXRD, DSC and FTIR, and it is shown that the six flavonoid compounds and meglumine successfully form a co-amorphous system. The solubility and the dissolution rate of the six flavonoid compound-meglumine co-amorphous substance are obviously superior to those of flavonoid bulk drugs, and the physical stability of the formed co-amorphous substance is obviously superior to that of a single amorphous drug, so that the co-amorphous substance shows good patent medicine performance.

The invention belongs to the technical field of perampanel medicines, and particularly relates to a perampanel medicine composition and a preparation thereof. The perampanel pharmaceutical composition provided by the invention comprises perampanel, Tween 80, a flavoring agent, a plasticizer and a film forming material, the pharmaceutical preparation of the perampanel pharmaceutical composition is a perampanel oral soluble film, and the preparation method of the perampanel oral soluble film comprises the following steps: mixing perampanel, first Tween 80 and an ethanol aqueous solution, performing vacuum freeze drying, and crushing to obtain freeze-dried powder; heating the freeze-dried powder to 20-30 DEG C, performing vacuum freeze-drying, and crushing to obtain secondary freeze-dried powder; mixing second Tween 80 with water, adding the secondary freeze-dried powder, a flavoring agent, a plasticizer and a film-forming material, and stirring to obtain slurry; and carrying out vacuum defoaming on the slurry, then coating a base material with the slurry, and drying to obtain the perampanel oral soluble film. The oral soluble film provided by the invention has the advantages of excellent content uniformity and stability, high dissolution rate and good flexibility.

The invention provides a light-nourishing tea and caffeine herbal beverage and a preparation method thereof.The beverage is prepared from tea leaves, coffee pericarp and herbaceous plants. According to the method, firstly, the natural fragrance in the coffee pericarp is improved through a far infrared fragrance improving technology; the dissolution rate of nutritional active ingredients in the coffee pericarp and herbaceous plants is promoted through a wall-breaking slow boiling technology, the shelf life stability of the beverage is improved through a low-temperature micropore refined filtration technology, and the defect that the tea fragrance of the beverage is unstable is overcome through a supercritical extraction technology. The product obtained by the preparation method not only contains natural aroma components of the tea caffeine raw material, organic acids, tea polyphenols, amino acids, flavonoids, polysaccharides and other components beneficial to human bodies, but also has rich health-preserving effects of the herbaceous plant raw material, such as oxidation resistance, inflammation resistance, immunity regulation and the like, and is suitable for large-scale popularization and sales in the market.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses an indobufen pharmaceutical composition, a tablet and a preparation method. According to the embodiment of the invention, indobufen, ground lactose and an internally added lubricant are co-crushed, the D90 particle size of the co-crushed material is controlled to be 10-40 [mu] m, then spray-dried lactose, microcrystalline cellulose and an internally added disintegrating agent are added for dry granulation, and finally an externally added disintegrating agent and an externally added lubricant are added for tabletting to prepare the indobufen tablet. Through the process, the prepared material is good in compressibility, the problems of sticking, tablet cracking, low hardness and the like in the tabletting process of indobufen are solved, meanwhile, the dissolution level of the prepared indobufen tablet in an acid medium is remarkably improved, the clinical effect of the product can be better exerted, and therefore replacement of an original product can be achieved; and the preparation is simple in production process, easy to realize large-scale industrial production, and relatively high in popularization and application value.

The invention discloses an anti-allergic probiotic composition as well as a preparation method and application thereof. The probiotic composition is prepared from the following raw materials in parts by weight: 10 to 50 parts of lactobacillus reuteri PG-LRL116, 10 to 50 parts of lactobacillus acidophilus, 10 to 50 parts of lactobacillus rhamnosus, 10 to 30 parts of lactobacillus gasseri, 10 to 30 parts of lactobacillus salivarius, 5 to 15 parts of cordyceps militaris aqueous extract, 5 to 15 parts of rosemary aqueous extract and 5 to 15 parts of dendrobium huoshanense yeast. The preparation method of the probiotic composition comprises the following steps: preparing the cordyceps militaris aqueous extract, the rosemary aqueous extract and the dendrobium huoshanense yeast; the preparation method comprises the following steps: uniformly mixing lactobacillus reuteri PG-LRL116, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus gasseri, lactobacillus salivarius, a cordyceps militaris aqueous extract, a rosemary aqueous extract and a dendrobium huoshanense fermentation product, so as to prepare the anti-allergic probiotic composition. The probiotic composition disclosed by the invention can be used for effectively inhibiting the occurrence of food sensitization reaction.

The invention discloses a preparation method of hemerocallis citrina nano-composite micro powder with high flavone release rate, which comprises the following steps: carrying out freeze drying treatment on fresh hemerocallis citrina, carrying out preliminary crushing, mixing the freeze-dried hemerocallis citrina with an auxiliary material and a disintegrating agent, carrying out infrasonic resonance treatment, taking microspheres as a force application medium in the process, carrying out acoustic resonance treatment, mixing, and screening to remove large particles, so as to obtain the hemerocallis citrina nano-composite micro powder with high flavone release rate. The day lily nano composite micro powder is obtained. The processing process does not need any solvent or additional chemical reagent, does not have excessive moisture and solvent residue, is good in safety, realizes superfine grinding and self-emulsification of the raw materials under the action of infrasound resonance force application, improves the release of flavone in an aqueous solution, and improves the product quality. Meanwhile, the inclusion material can further react with insoluble flavone in the day lily to form an inclusion compound and an intermolecular complex, so that the hydrophilicity is improved, and effective substances are promoted to be directly dissolved out, and therefore, after treatment, the capacities of resisting depression and promoting intestinal peristalsis are improved, and the aim of reducing the intake of the day lily under the same dosage is fulfilled.

The application discloses an anti-oxidation fermented Chinese herbal medicine mixed substitute tea and a preparation method thereof, and relates to the technical field of substitute tea processing and preparation. The anti-oxidation fermented Chinese herbal medicine mixed substitute tea comprises Sanghuang, Huangqi, Huangjing, Renshen and Gouqi, and the weight ratio of the raw materials is as follows: Sanghuang:Huangqi:Huangjing:Renshen:Gouqi = 4:2:2:1:1. The preparation method comprises the following steps: crushing, fermentation, drying, sterilization, sub-packaging, vacuum sealing, outer packaging, sampling quality inspection and storage in a warehouse. The anti-oxidation fermented Chinese herbal medicine mixed substitute tea is prepared by using a specific formula and biological fermentation of Inonotus hispidus, and the dissolution rate of anti-oxidation active ingredients of Chinese herbal medicines is significantly improved, and the anti-oxidation capacity is far superior to that of conventional physical mixed substitute tea. The fermentation process can efficiently degrade the cell walls of Chinese herbal medicines, so that the polysaccharides and other core anti-oxidation substances in Sanghuang, Huangqi, Huangjing, Renshen and Gouqi are fully released, DPPH, hydroxyl and other free radicals can be directly removed, and the Keap1-Nrf2-ARE signal path in the body can be activated, so that the anti-oxidation defense system of the body is doubly strengthened, and the anti-oxidation effect is improved from the root.

The invention belongs to the technical field of veterinary drugs, relates to a veterinary albendazole tablet, and provides a preparation method of the preparation. The tablet consists of albendazole, trehalose, sodium taurocholate and other pharmaceutically acceptable adhesives, disintegrating agents and lubricating agents. The albendazole is fully dispersed by spray-drying a mixed solution of albendazole, trehalose and sodium taurocholate, and the dosage of trehalose and sodium taurocholate is controlled, so that the dissolution and stability of the product are improved.

The invention provides a pharmaceutical composition of sodium ferrous citrate and a preparation method of the pharmaceutical composition, and belongs to the field of medicines. The pharmaceutical composition of the sodium ferrous citrate comprises the following components in percentage by mass: 70-95% of the sodium ferrous citrate, 1-30% of a filling agent, 1-10% of an adhesive and 1-10% of a lubricating agent, the filling agent comprises one or more of microcrystalline cellulose, calcium bicarbonate, lactose, mannitol, calcium hydrophosphate and corn starch. By adjusting the composition and proportion of the filling agent, the adhesive and the lubricant, the character of the product is improved, the sticking problem in the tabletting process is solved, the texture performance of the product is improved, the stability of ferrous iron in the pharmaceutical composition is improved, the friability is reduced, the bioavailability is improved, and the sodium ferrous citrate tablet is still smooth in surface after being stored for a long time, and has a good application prospect. The stability is excellent.

The invention relates to a fly ash-based hierarchical pore molecular sieve composite material as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve composite materials. In order to solve the problems that an existing fly ash based molecular sieve is single in pore structure, can only adsorb single pollutants and is complex in preparation process, the invention provides a preparation method of a fly ash based hierarchical pore molecular sieve composite material. The method comprises the following steps: carrying out mechanical-chemical coupling activation on fly ash, carrying out alkali fusion activation treatment, preparing a colloidal precursor, carrying out hydrothermal crystallization treatment, carrying out post-treatment on a crystallized product, and carrying out metal ion modification treatment. A micropore-mesopore-macropore three-level pore channel is constructed, the mass transfer efficiency and the adsorption activity are improved, double active sites are formed through metal modification, heavy metal and CO2 can be synchronously adsorbed, and the CO2 capacity is improved by 10-15% through heavy metal loading. The one-step method is adopted for preparation, the process is simplified, the cost is low, high consumption of fly ash is achieved, and the benefits of solid waste recycling and multi-pollutant cooperative treatment are achieved.

The present application relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a tea-substitute formula for treating insomnia in young and middle-aged people, which comprises the following steps: crushing fried jujube seeds, cleaning and draining dried yam, dried red mulberry and mixing them, mixing and stirring the plant lactobacillus powder and the medicinal materials, constant temperature fermentation and low temperature drying after sealing, coarse grinding after drying, mixing with sweet hibiscus and sweet marigold to obtain the tea-substitute formula. The tea-substitute formula for treating insomnia in young and middle-aged people and the preparation method thereof mainly use fried jujube seeds to nourish the heart and calm the nerves, yam to calm the heart and calm the nerves, and fuling to invigorate the spleen and calm the heart as auxiliary, and combine dried red mulberry to nourish yin and tonify blood, sweet hibiscus to relieve depression and calm the nerves, and sweet marigold to harmonize the taste, so as to regulate the balance of neurotransmitters from multiple targets, regulate sleep as a whole, and use the enzymes produced by microorganisms to destroy the cell wall of traditional Chinese medicine, so as to effectively improve the dissolution rate and biological conversion rate of sleep-aiding effective components such as jujube saponin and lily alkaloids.

This application discloses a traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons, its preparation method and application, belonging to the field of traditional Chinese veterinary medicine technology. This traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons comprises the following components by weight: 5-10 parts Sophora flavescens, 6-12 parts Andrographis paniculata, 3-8 parts Sanguisorba officinalis (charred), 2-4 parts Lonicera japonica, 2-4 parts Forsythia suspensa, 1-4 parts Coptis chinensis, 3-6 parts Codonopsis pilosula, 5-10 parts Astragalus membranaceus, 2-6 parts Ligusticum chuanxiong, 1-6 parts Ganoderma lucidum, 3-8 parts Ganoderma lucidum, 5-10 parts Isatis indigotica, 3-6 parts Scrophularia ningpoensis, 2-6 parts Buffalo horn, 2-6 parts Dryopteris crassirhizoma (charred), 2-6 parts Sanguisorba officinalis, 5-15 parts Three Needles (charred), 2-10 parts Scutellaria baicalensis, 6-12 parts Lonicera japonica, 6-12 parts Pteris multifida, 4-10 parts Artemisia annua, 4-10 parts Atractylodes lancea, 4-14 parts Gypsum fibrosum, 6-12 parts Glycyrrhiza uralensis (tip), 2-5 parts Prunus armeniaca, 2-8 parts Epimedium brevicornu, and 2-5 parts Rhodiola rosea. By limiting the composition and ratio of the ingredients, the various medicinal materials complement each other in terms of their cold and heat properties and work together to break through the limitations of conventional Chinese medicine's single heat-clearing function. It can simultaneously improve viral infections, watery enteritis, and emaciation, and is suitable for use in the feed of meat pigeons and racing pigeons at all stages.

The application belongs to the technical field of microcapsules, and particularly relates to a preparation method of a composite probiotic capsule, which comprises the following steps: uniformly mixing probiotic bacterial liquid, fructooligosaccharide, tea polyphenol, grape polyphenol, mannan oligosaccharide, isomaltitol and an emulsifier to obtain a core material; uniformly mixing glycerol and distilled water, heating to 60-80 DEG C, sequentially adding modified gelatin, hydroxypropyl starch and chitosan, stirring for 10-30 min, sterilizing, and cooling to room temperature to obtain a capsule material; mixing the core material and the capsule material, performing high-pressure homogenization treatment, and then performing spray drying to obtain the composite probiotic capsule; and the modified gelatin is prepared by acylation reaction of succinic acid derivatives and gelatin. The composite probiotic capsule provided by the application has excellent storage stability, antioxidant property, anti-gastric juice erosion capacity, and also has good enteric solubility and bioavailability.

The present invention provides a dolutegravir oxalic acid cocrystal and a preparation method and application thereof. The dolutegravir oxalic acid cocrystal is prepared by combining dolutegravir and oxalic acid in a molar ratio of 1:1, and has a molecular formula of C 22 H 21 F2N3O9, the relative molecular mass is 509.41. The dolutegravir oxalic acid cocrystal provided by the present invention is a new crystal form, which can improve the dissolution of dolutegravir without changing the covalent bonds of dolutegravir, thereby improving the efficacy and bioavailability. The present invention adopts a grinding reaction crystallization method or a suspension reaction crystallization method to prepare the dolutegravir oxalic acid cocrystal, which has simple process, mild conditions, good repeatability, green and environmental protection, and is suitable for large-scale production.

The invention discloses a cyclocarya paliurus eurotium cristatum dark tea compound beverage and a preparation method thereof. The method comprises the following steps: a biotransformation extraction step: crushing herbal raw materials to obtain mixed micro-powder, and carrying out co-fermentation enzymolysis on the mixed micro-powder and activated eurotium cristatum-containing golden flower dark tea powder in water to obtain a biotransformation herbal extracting solution; a coffee extraction step: performing low-temperature extraction and concentration on coffee beans to obtain a coffee concentrated solution; homogenizing and embedding, namely mixing the extracting solution, the concentrated solution and inulin, and performing high-pressure homogenizing treatment; and a drying and forming step: performing vacuum freeze drying on the homogenized feed liquid to obtain powder. The composition comprises the biotransformed herbal component prepared by the method, a coffee component and an inulin component. Herbal raw materials are biologically converted through an extracellular enzyme system of eurotium cristatum, the dissolution rate of functional components is increased, natural bitterness removal and sweetness increase are achieved, the product flavor is improved, and the biological activity is enhanced.

The present invention relates to a neratinib maleate pharmaceutical composition and tablets that can be used for treating breast cancer and a preparation method thereof, wherein the pharmaceutical composition comprises neratinib maleate, meglumine and sodium sulfate. The formulation solves the problems of granulation adhesion, dissolution and stability of neratinib maleate, and the obtained preparation can maintain good fluidity without granulation, has good dissolution and significantly improves the stability of neratinib maleate, and has a simple formulation process and good application value.

The present invention relates to a composition and a preparation method and use thereof, belonging to the field of pharmaceutical preparations. The composition comprises an ATV014 compound and a pharmaceutically acceptable excipient, has good stability, high solubility, and high bioavailability, and can be used to prevent, alleviate or treat coronavirus infection or the replication or reproduction of its homologous variant virus and the resulting cytopathic effect.

The invention belongs to the technical field of medicines, and particularly relates to a ketoprofen in-situ co-amorphous composition. The co-amorphous composition is prepared from ketoprofen, lysine, arginine and meglumine, and homogeneous disordered arrangement can be spontaneously formed when the co-amorphous composition is in contact with an aqueous medium (including a dissolution process). Through powder X-ray diffraction, differential scanning calorimetry and Fourier infrared spectroscopic analysis, the three combinations can be subjected to in-situ co-amorphization in contact with a trace aqueous medium or in a dissolution process, so that the solubility and the dissolution rate of ketoprofen are remarkably improved, and the oral absorption and treatment effects of ketoprofen are expected to be enhanced. Meanwhile, the degree of in-situ co-amorphization is closely related to composition molar ratio, contact time, medium pH and temperature. The invention provides a new preparation thought for mediating in-situ co-amorphous generation of ketoprofen through prescription composition and design and improving the defects of drug solubility and dissolution rate.

The invention relates to the technical field of agricultural product deep processing and functional food science, in particular to enzymolysis cyperus esculentus powder and a preparation method and application thereof. The preparation method comprises the steps that cyperus esculentus powder and water are mixed, pulped and cured; performing high-speed shearing pretreatment on the slurry; adding a compound enzyme preparation containing amylase, cellulase and protease for enzymolysis; carrying out enzyme deactivation after enzymolysis, and filtering; performing emulsification and two-stage high-pressure homogenization treatment on the filtrate; and finally spray-drying to obtain a finished product. Through the synergistic effect of high-speed shearing and composite enzymolysis, cell walls of cyperus esculentus are effectively broken, macromolecular nutrient substances are converted into micromolecules, and the solubility, taste and nutrition utilization rate of the product are remarkably improved. The prepared enzymolysis cyperus esculentus powder is good in instant solubility, good in flavor and high in stability, and can be widely applied to the fields of solid beverages, special dietary foods and the like.

The invention provides a Naoluotong capsule and a preparation method thereof, and belongs to the technical field of medicines. The Naoluotong capsule is prepared from the following components in parts by weight: 40 to 60 parts of radix salviae miltiorrhizae extract, 40 to 60 parts of rhizoma chuanxiong extract, 40 to 60 parts of radix astragali seu hedysari extract, 40 to 60 parts of tolperidone hydrochloride, 5 to 15 parts of methyl hesperidin, 1 to 4 parts of vitamin B6, 12 to 25 parts of polyvinylpyrrolidone K30, 13 to 25 parts of polyethylene glycol 400, 32 to 42 parts of corn starch, 3 to 7 parts of magnesium stearate and 200 to 250 parts of ethanol aqueous solution with the volume concentration of 70 to 80 percent. The Naoluotong capsule prepared by the invention is short in disintegration time, good in stability and high in tolperidone hydrochloride content.

The present invention provides a new gastrodin crystal form, and the X-ray powder diffraction spectrum obtained by using Cu-Kα ray measurement shows that the crystal form is discovered for the first time, and the present invention enriches the crystal form research of gastrodin. The preparation process of the present invention is simple, and the obtained crystal form compound has high purity, good solubility and high bioavailability, which greatly broadens the application scenarios of gastrodin and improves the compliance of patients with medication.

The invention belongs to the technical field of Chinese medicine preparation, and specifically is a preparation method and application of a Chinese medicine preparation for treating hypertension complicating pregnancy. The method comprises the following steps: washing and drying Chinese medicinal materials in a prescribed amount, crushing them respectively, and mixing them uniformly to obtain a mixed powder A; soaking the remaining components in water according to the prescribed amount, decocting, filtering, and concentrating to obtain a Chinese medicine extract with a relative density; putting the obtained extract into a vacuum dryer for fluidized drying, and crushing them to obtain a mixed powder B after combined operation; and mixing the mixed powder A and the mixed powder B uniformly and sealing them for storage to obtain a finished product, so as to give full play to the efficacy of each medicine and avoid the loss of efficacy, so as to achieve a high release rate of the effective ingredients of the medicine, and significantly improve the stability and solubility of the medicine, thereby improving the therapeutic effect and cure rate of the medicine.