33results about How to "High dissolution rate" patented technology

The application discloses an anti-oxidation fermented Chinese herbal medicine mixed substitute tea and a preparation method thereof, and relates to the technical field of substitute tea processing and preparation. The anti-oxidation fermented Chinese herbal medicine mixed substitute tea comprises Sanghuang, Huangqi, Huangjing, Renshen and Gouqi, and the weight ratio of the raw materials is as follows: Sanghuang:Huangqi:Huangjing:Renshen:Gouqi = 4:2:2:1:1. The preparation method comprises the following steps: crushing, fermentation, drying, sterilization, sub-packaging, vacuum sealing, outer packaging, sampling quality inspection and storage in a warehouse. The anti-oxidation fermented Chinese herbal medicine mixed substitute tea is prepared by using a specific formula and biological fermentation of Inonotus hispidus, and the dissolution rate of anti-oxidation active ingredients of Chinese herbal medicines is significantly improved, and the anti-oxidation capacity is far superior to that of conventional physical mixed substitute tea. The fermentation process can efficiently degrade the cell walls of Chinese herbal medicines, so that the polysaccharides and other core anti-oxidation substances in Sanghuang, Huangqi, Huangjing, Renshen and Gouqi are fully released, DPPH, hydroxyl and other free radicals can be directly removed, and the Keap1-Nrf2-ARE signal path in the body can be activated, so that the anti-oxidation defense system of the body is doubly strengthened, and the anti-oxidation effect is improved from the root.

The invention relates to a fly ash-based hierarchical pore molecular sieve composite material as well as a preparation method and application thereof, and belongs to the technical field of molecular sieve composite materials. In order to solve the problems that an existing fly ash based molecular sieve is single in pore structure, can only adsorb single pollutants and is complex in preparation process, the invention provides a preparation method of a fly ash based hierarchical pore molecular sieve composite material. The method comprises the following steps: carrying out mechanical-chemical coupling activation on fly ash, carrying out alkali fusion activation treatment, preparing a colloidal precursor, carrying out hydrothermal crystallization treatment, carrying out post-treatment on a crystallized product, and carrying out metal ion modification treatment. A micropore-mesopore-macropore three-level pore channel is constructed, the mass transfer efficiency and the adsorption activity are improved, double active sites are formed through metal modification, heavy metal and CO2 can be synchronously adsorbed, and the CO2 capacity is improved by 10-15% through heavy metal loading. The one-step method is adopted for preparation, the process is simplified, the cost is low, high consumption of fly ash is achieved, and the benefits of solid waste recycling and multi-pollutant cooperative treatment are achieved.

This application discloses a traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons, its preparation method and application, belonging to the field of traditional Chinese veterinary medicine technology. This traditional Chinese medicine preparation for intestinal repair and antiviral immunity in pigeons comprises the following components by weight: 5-10 parts Sophora flavescens, 6-12 parts Andrographis paniculata, 3-8 parts Sanguisorba officinalis (charred), 2-4 parts Lonicera japonica, 2-4 parts Forsythia suspensa, 1-4 parts Coptis chinensis, 3-6 parts Codonopsis pilosula, 5-10 parts Astragalus membranaceus, 2-6 parts Ligusticum chuanxiong, 1-6 parts Ganoderma lucidum, 3-8 parts Ganoderma lucidum, 5-10 parts Isatis indigotica, 3-6 parts Scrophularia ningpoensis, 2-6 parts Buffalo horn, 2-6 parts Dryopteris crassirhizoma (charred), 2-6 parts Sanguisorba officinalis, 5-15 parts Three Needles (charred), 2-10 parts Scutellaria baicalensis, 6-12 parts Lonicera japonica, 6-12 parts Pteris multifida, 4-10 parts Artemisia annua, 4-10 parts Atractylodes lancea, 4-14 parts Gypsum fibrosum, 6-12 parts Glycyrrhiza uralensis (tip), 2-5 parts Prunus armeniaca, 2-8 parts Epimedium brevicornu, and 2-5 parts Rhodiola rosea. By limiting the composition and ratio of the ingredients, the various medicinal materials complement each other in terms of their cold and heat properties and work together to break through the limitations of conventional Chinese medicine's single heat-clearing function. It can simultaneously improve viral infections, watery enteritis, and emaciation, and is suitable for use in the feed of meat pigeons and racing pigeons at all stages.

The application belongs to the technical field of microcapsules, and particularly relates to a preparation method of a composite probiotic capsule, which comprises the following steps: uniformly mixing probiotic bacterial liquid, fructooligosaccharide, tea polyphenol, grape polyphenol, mannan oligosaccharide, isomaltitol and an emulsifier to obtain a core material; uniformly mixing glycerol and distilled water, heating to 60-80 DEG C, sequentially adding modified gelatin, hydroxypropyl starch and chitosan, stirring for 10-30 min, sterilizing, and cooling to room temperature to obtain a capsule material; mixing the core material and the capsule material, performing high-pressure homogenization treatment, and then performing spray drying to obtain the composite probiotic capsule; and the modified gelatin is prepared by acylation reaction of succinic acid derivatives and gelatin. The composite probiotic capsule provided by the application has excellent storage stability, antioxidant property, anti-gastric juice erosion capacity, and also has good enteric solubility and bioavailability.

The invention discloses a cyclocarya paliurus eurotium cristatum dark tea compound beverage and a preparation method thereof. The method comprises the following steps: a biotransformation extraction step: crushing herbal raw materials to obtain mixed micro-powder, and carrying out co-fermentation enzymolysis on the mixed micro-powder and activated eurotium cristatum-containing golden flower dark tea powder in water to obtain a biotransformation herbal extracting solution; a coffee extraction step: performing low-temperature extraction and concentration on coffee beans to obtain a coffee concentrated solution; homogenizing and embedding, namely mixing the extracting solution, the concentrated solution and inulin, and performing high-pressure homogenizing treatment; and a drying and forming step: performing vacuum freeze drying on the homogenized feed liquid to obtain powder. The composition comprises the biotransformed herbal component prepared by the method, a coffee component and an inulin component. Herbal raw materials are biologically converted through an extracellular enzyme system of eurotium cristatum, the dissolution rate of functional components is increased, natural bitterness removal and sweetness increase are achieved, the product flavor is improved, and the biological activity is enhanced.

The invention relates to the technical field of agricultural product deep processing and functional food science, in particular to enzymolysis cyperus esculentus powder and a preparation method and application thereof. The preparation method comprises the steps that cyperus esculentus powder and water are mixed, pulped and cured; performing high-speed shearing pretreatment on the slurry; adding a compound enzyme preparation containing amylase, cellulase and protease for enzymolysis; carrying out enzyme deactivation after enzymolysis, and filtering; performing emulsification and two-stage high-pressure homogenization treatment on the filtrate; and finally spray-drying to obtain a finished product. Through the synergistic effect of high-speed shearing and composite enzymolysis, cell walls of cyperus esculentus are effectively broken, macromolecular nutrient substances are converted into micromolecules, and the solubility, taste and nutrition utilization rate of the product are remarkably improved. The prepared enzymolysis cyperus esculentus powder is good in instant solubility, good in flavor and high in stability, and can be widely applied to the fields of solid beverages, special dietary foods and the like.

The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparation. The invention provides a 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic which is formed by combining 3, 5-dihydroxy-4'-pentylbiphenyl and betaine through an intermolecular hydrogen bond, and a preparation method of the 3, 5-dihydroxy-4 '-pentylbiphenyl-betaine eutectic. According to the 3, 5-dihydroxyl-4 '-pentylbiphenyl-betaine eutectic and the preparation method thereof, the eutectic is formed by BP and BET, the solubility and the dissolution rate of BP are improved, the application amount of pesticide molecules is reduced, and the 3, 5-dihydroxyl-4'-pentylbiphenyl-betaine eutectic is applied to various plant pathogenic fungi. Results of the embodiment show that the co-crystals formed by BP and BET are combined through hydrogen bonds in a molar ratio of 1: 1, the dissolution effect of the co-crystals is superior to that of the medicine, and the dissolution effect is not affected by the pH environment. Compared with drugs with the same concentration and the drug eutecticum, the drug eutecticum shows the antibacterial activity advantage superior to that of original drug molecules.

The application provides a method for improving the sensitivity of liquid chromatography-mass spectrometry in detecting vitamin K1 in serum, which comprises the following steps: preparing a sample solution of vitamin K1 to be detected by using a liquid-liquid extraction method to obtain an initial sample solution; and redissolving the initial sample solution by using an aqueous solution containing at least isopropanol as a redissolving agent to obtain a sample solution to be detected; and adding ammonium fluoride after an LC-MS column to improve the mass spectrometry detection sensitivity of the vitamin K1 sample. By using the technical scheme of the application, isopropanol or isopropanol+methanol is used as a redissolving agent to replace methanol in the prior art as a redissolving agent, the mass spectrometry detection sensitivity of VK1 is improved, the recovery rate is improved, the detection method has good stability, and the clinical detection requirements can be met; meanwhile, the ammonium fluoride in the liquid chromatography can be completely replaced, the system pressure of the liquid chromatograph is reduced, and the service life of the chromatographic column is prolonged.

The invention provides a continuous squeezing type pharmaceutical extraction device, which relates to the technical field of squeezing pharmaceutical extraction, and comprises an extraction rack, a feed hopper, a crushing mechanism, a conveying mechanism, a primary squeezing mechanism, a secondary squeezing mechanism, a filtering mechanism, a liquid storage tank, a residue collection box, a driving shaft, a transmission gear set, a manual rocking handle, a guide slide rail, a support cross beam and a fixing bolt, by arranging the crushing mechanism, medicinal materials can be fully crushed, the contact area between the medicinal materials and an extraction solvent is increased, and the dissolution rate of effective components is increased; through a multi-stage filtering mechanism, fine residues in the liquid medicine can be effectively separated, and the purity of the liquid medicine is improved; by means of the pure mechanical continuous structural design of smashing, conveying, two-stage squeezing and multi-stage filtering, full-process automatic treatment of medicinal materials from feeding to finished medicine liquid is achieved, and compared with a traditional sectional type extraction device, the operation efficiency is improved by 60% or above.

The application discloses a kind of tea branch orange superfine powder with anti-inflammatory efficacy and a preparation method thereof.The tea branch orange superfine powder comprises the following raw material components by mass fraction: 15-30 parts of tea branch orange pericarp powder, 30-50 parts of tea branch orange pulp powder, and 4-8 parts of tea branch orange seed powder.By efficiently compounding different parts of tea branch orange, the best anti-inflammatory effect is achieved, and the efficient use of whole fruit is realized, which is conducive to reducing environmental pollution and resource waste and improving economic benefits.The preparation method is to sequentially use high-voltage pulsed electric field, pressure difference puffing and vacuum freeze drying to separate the pulp and seeds, and then dry low-temperature superfine grind tea branch orange pericarp, pulp and seeds, and compound the raw material components to obtain tea branch orange superfine powder with anti-inflammatory efficacy.The synergistic effect of multiple processing technologies significantly improves the dissolution of functional active substances such as anti-inflammatory components, and the tea branch orange superfine powder with good anti-inflammatory effect is obtained by combining component compounding.

The invention discloses a coal gangue microwave-chemical synergistic activation method and activated coal gangue, the coal gangue microwave-chemical synergistic activation method comprises the following steps: (1) crushing coal gangue to obtain a crushed product; (2) mixing the crushed product with a composite activator, and performing microwave treatment to obtain an activated product; the composite activating agent comprises waste alkali liquor, fly ash aluminum extraction residues and water glass; and (3) drying, cooling and grinding the activated product to obtain the activated coal gangue. The microwave-chemical synergistic activation method for the coal gangue is high in activation efficiency, efficient destruction of crystal lattices of coal gangue minerals is achieved through the synergistic effect of microwaves and the composite activating agent, the activation time is shortened, the silicon-aluminum dissolution rate is increased, the silicon dissolution rate reaches 80% or above, the aluminum dissolution rate reaches 70% or above, the problem that single chemical activation is low in efficiency is solved, and the method is suitable for industrial production. And the obtained activated coal gangue product has high activity.

This utility model relates to the field of white willow bark processing equipment, and discloses a white willow bark raw material crushing and alkalization device, including a mixing box and a processing box. The right side of the mixing box and the left side of the processing box are connected by a conveying mechanism. A crushing mechanism is arranged inside the processing box, and a proportioning mechanism is arranged on the top of the mixing box. The proportioning mechanism includes a proportioning cylinder and a vertical pipe fixedly connected to the proportioning cylinder. The bottom of the vertical pipe is fixedly connected to the inner wall of the mixing box, and a connecting pipe is fixedly connected to the bottom of the vertical pipe. An annular pipe is fixedly connected to the end of the connecting pipe away from the vertical pipe. In this utility model, the proportioning accuracy of the alkali solution is improved by the design of two sets of proportioning cylinders and their scale lines in the proportioning mechanism. The stirring blades in the mixing box, driven by a third drive motor, ensure that the white willow bark raw material and the alkali solution are fully mixed, providing uniform and stable reaction conditions for the subsequent alkalization reaction and improving the extraction efficiency of effective components.

This invention discloses a fermented traditional Chinese medicine product, its preparation method, and its application, belonging to the field of traditional Chinese medicine fermentation technology. The product uses peppermint, astragalus, wolfberry, mulberry bark, anemarrhena, arborvitae leaf, scrophularia, cimicifuga, elsholtzia, angelica, lily, ginkgo, licorice, schisandra, eleutherococcus senticosus, ophiopogon japonicus, and dried ginger as raw materials, sorghum as a co-fermentation raw material, and brewing liquid as a fermentation enhancer. The process involves pretreatment of the traditional Chinese medicine, co-cooking with sorghum, saccharification with small-grain starter, segmented fermentation, extraction and purification, and post-treatment. This invention utilizes a "compound traditional Chinese medicine ~ sorghum" co-fermentation system, combined with the microbial community and active substances rich in brewing liquid, to increase the dissolution rate of active ingredients such as astragaloside A, lily polysaccharide, and wolfberry polysaccharide in the traditional Chinese medicine by more than 50%, while simultaneously converting them into easily absorbed small molecule derivatives. The finished product has an alcohol content controlled at 6-8 degrees, which not only promotes the absorption of active ingredients but also possesses synergistic effects of clearing the lungs and regulating qi, tonifying qi and benefiting the lungs, moistening the lungs and relieving cough, and clearing heat and resolving phlegm. The process enables the resource utilization of yellow water from brewing, reducing costs by 35%, and the product exhibits excellent stability, making it suitable for industrial production. It also has significant value in the field of lung function regulation and health care.

This invention discloses a method for preparing tangerine peel wine-roasted tea vinegar, its preparation method, drinking method, and set of utensils. The invention uses Xinhui tangerine peel wine, Xinhui tangerine peel strips aged for more than 3 years, and tea leaves at a specific degree of fermentation as core raw materials. Through an integrated process of "immersion-roasting with wine and fire-inducing steeping under negative pressure," the stable instantaneous negative pressure simultaneously achieves the directional and gentle acetylene transformation of ethanol via acetaldehyde intermediates, the removal of the cold and irritating properties of tea leaves, and the synergistic and efficient extraction of multiple flavor sources and active substances within tens of seconds. This invention transforms traditional methods into a quantifiable and repeatable standardized process, solving the technical problems of existing technologies such as the strong cold nature of lightly fermented teas, the dependence of high-quality mellow taste on long-term aging, the difficulty in quickly integrating multiple flavor sources, and the inability to standardize and replicate traditional methods. The resulting beverage has a pH value of 3.0~4.5 and an ethanol residue of ≤0.5% vol, possessing both flavor harmony and wide drinkability, facilitating standardized, reproducible, and widespread application.

This utility model discloses a non-ferrous metal smelting waste residue grading and recycling device, including a base plate, a defluorination unit, and a waste residue screening unit. An installation frame is welded to the left side of the top surface of the base plate, and the defluorination unit is fixed to the top surface of the installation frame. A solid-liquid separation box is welded to the side wall of the installation frame. An agitator is fixed to the inside of the defluorination unit by bolts. In this utility model, the waste residue screening unit achieves high-frequency synchronous vibration of the upper and lower screen buckets through a linkage structure of "motor, transmission rod, disc cam, and spring," completing three-stage particle size classification in one go. Compared with the existing multi-equipment combination of "cyclone separator + high-frequency screen," this significantly improves the grading efficiency. The coarse, medium, and fine slags after grading by the double-layer screen buckets can be used to extract metallic aluminum, alumina and calcium fluoride, and to produce building materials, respectively. There is no waste residue stockpiling, the solid waste utilization rate is high, and the risk of land occupation and slag leakage pollution is reduced.

The application aims to establish a solubilization system for improving the dissolution of silymarin and prepare silymarin-loaded polymer microspheres, and belongs to the technical field of pharmaceutical preparations. The silymarin polymer microspheres prepared by the solubilization system can significantly improve the dissolution of silymarin. The method for preparing the silymarin polymer microspheres in the application is as follows: S1: uniformly mixing pre-activated corn starch, nicotinamide and O / W emulsifier in deionized water to form an aqueous phase; S2: dissolving silymarin in ethyl acetate to form an oil phase; S3: slowly adding the oil phase to the aqueous phase and stirring at high speed to prepare an emulsion; S4: placing the emulsion in an ice water bath for several hours, centrifuging, taking the precipitate, and freeze-drying to obtain silymarin microspheres.

The invention relates to the technical field of deep processing of tea leaves, and discloses a preparation process of medicinal and edible fermented tea, which sequentially comprises the steps of tea base prefabrication, medicine source enzymatic hydrolysate preparation, dietary fiber auxiliary material recovery, inoculated fermentation and gradient drying. The method is characterized in that a physical structure beneficial to microbial colonization is constructed by controlling the cell breakage rate of tea bases; a compound enzyme system containing cellulase, pectinase and beta-glucosidase is adopted for carrying out directional hydrolysis on raw materials such as rhizoma polygonati and radix puerariae, bitter glycoside is converted into sweet aglycone, and an ultramicro dietary fiber auxiliary material is prepared to serve as a fermentation carrier; after the eurotium cristatum is inoculated, the uniform growth of the golden flowers and the formation of flavor substances are promoted through two-stage temperature-control and humidity-control fermentation; and finally performing gradient drying to obtain a finished product. The process effectively solves the problems of few eurotium cristatum, heavy medicine flavor and rough taste of the traditional medicinal and edible fermented tea, realizes deep fusion of fungus fragrance and medicine fragrance tea fragrance, and has the advantages of flourishing eurotium cristatum, smooth soup feeling and stable quality.

This invention discloses a solid dispersion, a pharmaceutical composition, a method for preparing the same, and its application. The solid dispersion of this invention comprises: (1) a compound of formula () or a pharmaceutically acceptable salt thereof; and (2) a polymer carrier, wherein the polymer carrier comprises one or more of copovidone, povidone, and hydroxypropyl methylcellulose; formula ().

This invention belongs to the field of feed additives, and particularly relates to a montmorillonite-co-loaded silymarin nanosuspension and its preparation method. The montmorillonite-co-loaded silymarin nanosuspension comprises montmorillonite, silymarin, liquid phospholipids, and chitosan, wherein silymarin is loaded onto the surface and interlayer of montmorillonite via liquid phospholipids, forming a nano-dispersion system with a particle size distribution of 150–320 nm. The montmorillonite-co-loaded silymarin nanosuspension and its preparation method provided by this invention achieve efficient loading, nano-dispersion, and liver-targeted delivery of silymarin.

The application provides a compound omeprazole dry suspension and a preparation method thereof, and relates to the technical field of pharmaceutical preparations.The compound omeprazole dry suspension comprises the following raw materials: omeprazole, sodium bicarbonate, magnesium silico-aluminate, hard stearic acid modified hydrotalcite, low acyl gellan gum, hydroxypropyl methyl cellulose and trehalose.The application provides a compound omeprazole dry suspension and a preparation method thereof, and the compound omeprazole dry suspension with specific particle size is prepared through specific proportioning of auxiliary materials and a specific preparation process, and the stability and solubility are significantly improved.

The invention discloses vigor-nourishing wine and a preparation process thereof, and relates to the technical field of health-preserving wine preparation processes, the vigor-nourishing wine comprises 10-30 parts of semen cuscutae, 10-25 parts of polygonum multiflorum, 10-25 parts of codonopsis pilosula, 10-25 parts of astragalus membranaceus, 8-20 parts of herba epimedii, 8-20 parts of radix puerariae, 5-15 parts of angelica sinensis, 5-15 parts of poria cocos, 5-15 parts of cassia twig, 5-15 parts of medlar, 5-15 parts of jujube and 5-15 parts of schisandra chinensis. Semen cuscutae and radix polygoni multiflori are used as monarch drugs to tonify kidney and replenish essence and consolidate basis; codonopsis pilosula and astragalus membranaceus are used as ministerial drugs to tonify qi and spleen and strengthen healthy energy and consolidate superficies; herba epimedii, radix puerariae, angelica sinensis and the like are used as assistants and guides for promoting blood circulation to remove meridian obstruction and regulating yin and yang The twelve medicinal materials have a synergistic effect and have the effects of tonifying primordial qi, regulating yin and yang and dredging meridians and collaterals.

The application discloses a preparation method of cordyceps sinensis, and relates to the technical field of medicine preparation. A specific implementation mode of the method comprises the following steps: cooling the cleaned cordyceps sinensis to a first temperature which is lower than a eutectic point, so that the water in the cordyceps sinensis is completely frozen to form ice crystals; performing at least one freeze-thaw cycle, wherein the freeze-thaw cycle comprises the following steps: increasing the temperature to a second temperature which is higher than 0 DEG C, so that the frozen cordyceps sinensis is thawed, and then the temperature is decreased to the first temperature at a second decreasing rate, so that the cordyceps sinensis is re-frozen; placing the cordyceps sinensis in a vacuum environment, and performing at least one pressure change treatment; and performing temperature increasing drying under the vacuum condition, until a predetermined water content is reached. The implementation mode significantly improves the dissolution rate of effective substances when the user takes the cordyceps sinensis, and improves the bioavailability of the cordyceps sinensis; uniform, loose and crisp textures are formed, so that a unique taste of melting in the mouth is brought, and the problem of hard taste and poor palatability of traditional freeze-dried cordyceps sinensis is solved.

This invention discloses a method and apparatus for recovering carbon sources from residual sludge through multi-stage ultrasonic treatment, relating to the field of wastewater treatment technology. The method for recovering carbon sources from residual sludge through multi-stage ultrasonic treatment includes the following steps: (1) subjecting the residual sludge to a first-stage ultrasonic treatment with an acoustic energy density of 0.8 W / mL to 1.2 W / mL and an ultrasonic treatment time of T1; (2) subjecting the sludge treated in step (1) to a second-stage ultrasonic treatment with an acoustic energy density of 0.4 W / mL to 0.7 W / mL and an ultrasonic treatment time of T2; (3) subjecting the sludge treated in step (2) to a third-stage ultrasonic treatment with an acoustic energy density of 0.1 W / mL to 0.3 W / mL and an ultrasonic treatment time of T3; wherein T1+T2+T3 < 10 min. Using this invention, carbon sources can be efficiently recovered while reducing the disruption of functional microorganisms and retaining some extracellular polymers to maintain the activity of functional microorganisms.

A compound feed additive for improving egg quality, its preparation method, and its application are disclosed. The raw materials of the compound feed additive are composed of the following by weight percentage: 65-75% three-stage temperature-controlled fermented mulberry leaf powder, 8-12% compound probiotic microcapsule preparation, and 15-25% functional carrier. 5-8% of the compound feed additive prepared according to this invention is added to the basal diet of laying hens and fed continuously for 42-56 days. The three-stage temperature-controlled fermentation of this invention reduces the tannin content in mulberry leaves from 7.2 mg / g to below 4.7 mg / g, with a degradation rate ≥30%. The low tannin content improves feed palatability and effectively solves the problem of decreased feed intake caused by high-dose mulberry leaf addition.

The application relates to the technical field of medicines, in particular to an icotinamide tablet of icotinib and a preparation method thereof; the icotinamide tablet of icotinib comprises the following components: icotinamide, an amphiphilic carrier, a microenvironment regulator and pharmaceutically acceptable adjuvants, wherein the mass ratio of the icotinamide, the amphiphilic carrier and the microenvironment regulator is 1:(1-3):(0.5-1.5), the amphiphilic carrier is Soluplus, and the microenvironment regulator is meglumine; the application discloses an icotinamide tablet of icotinib and a preparation method thereof; the three components of icotinamide, the amphiphilic carrier Soluplus and the microenvironment regulator meglumine are ground together, the solubility and the dissolution of the medicine in a high-calcium medium can be effectively improved, the postprandial bioavailability is increased, and the stability is good.

This invention belongs to the field of biotechnology. Specifically, it discloses a method for preparing recombinant protein using rice seeds. The method involves dehulling rice seeds to obtain rice flour, which is then enzymatically hydrolyzed using cellulase and neutral protease in a buffer solution. This process efficiently hydrolyzes the cellulose in the rice cell wall and some impurities. The buffer solution reduces protein salting out and increases the dissolution rate of recombinant human lactoferrin. Activated carbon is used to initially adsorb and remove impurities such as natural pigments and phenolic substances from the rice seeds. The mixture is then subjected to chromatography using CM Sepharose FF, SP Sepharose XL, and CM Sepharose FF columns, effectively improving the purity and recovery rate of the recombinant human lactoferrin. Simultaneously, the enzymatic hydrolysis and fractionation chromatography effectively reduce the iron saturation in the recombinant human lactoferrin.

The application provides a brexpiprazole oral film, a preparation method and application thereof. The brexpiprazole oral film comprises the following components: an active drug and a film-forming material, wherein the active drug is 7-[4-(4-benzo[B]thiophene-4-yl-1-piperazine) butoxy]-2(1H)-quinolinone as shown in formula I and / or a pharmaceutically acceptable salt thereof, the particle size D 90 ≤70 μm of the active drug; the film-forming material is one or more of hydroxypropyl methyl cellulose, polyvinyl alcohol and hydroxypropyl cellulose; and the brexpiprazole oral film does not contain dimethyl silicone oil. The brexpiprazole oral film of the application has a good dissolution rate, does not have a sand feeling after being dissolved in the oral cavity, has a uniform appearance, good flexibility, does not settle during the preparation of the film liquid, and has a uniform content.

The application discloses a kind of solid dispersion nanoparticles and preparation method thereof, belong to medical technology field, using SAS process to obtain drug-carrier solution to further prepare telmisartan binary solid dispersion and telmisartan ternary solid dispersion.The application uses the above-mentioned one kind of solid dispersion nanoparticles and preparation method thereof, using SAS method successfully prepares telmisartan binary solid dispersion, ternary solid dispersion;And the construction of SAS method to telmisartan solid dispersion system, breaks through the limitation of traditional method, can accurately control particle size, stable formation amorphous drug to improve dissolution, can also protect the activity of heat-sensitive component and realize low solvent residue, with process flexibility and industrialization potential.

The present application relates to a kind of dry suspension preparations of montelukast sodium, belong to the field of pharmaceutical pharmacy.The dry suspension preparation component is composed of montelukast sodium, carbomer, fumed silica, corn starch, sucrose, cherry powder essence, banana powder essence.By montelukast sodium and carbomer primary coating, again with fumed silica coating, enhanced protective layer, avoid the continued destruction of external light, oxygen, good stability effect is obtained.Through accelerated test, long-term test investigation, appearance, dissolution, content, related substances are superior to prior art.Preparation process uses large particle size solid drug substance, avoids the loss of raw material in preparation process, product preparation process is simple, easy to operate, quality meets the requirements, facilitate commercial production.

The invention relates to the technical field of corrosion prevention and tissue regeneration promotion, in particular to a preparation method for preparing corrosion prevention and tissue regeneration promotion based on a wall breaking technology, and the corrosion prevention and tissue regeneration promotion is prepared from the following raw materials in parts by weight: 30-60 parts of calcined calamine, 15-30 parts of myrrh, 1-2 parts of sal ammoniac, 10-20 parts of realgar, 15-30 parts of borax, 1.5-3 parts of borneol and 15-30 parts of frankincense. Optionally, the composition also comprises 0.5-1 part of pearl. The traditional preservative and tissue regeneration promoting traditional Chinese medicine formula is optimized, the calcined calamine, the frankincense and the myrrh are taken as cores and matched with the sal ammoniac, the realgar, the borax and the borneol, all the medicines are combined, the synergistic effects of removing slough, promoting tissue regeneration, activating blood, detoxifying, preventing corrosion and resisting bacteria are achieved, healing of skin ulcers, scrofula, fester and other wounds can be effectively promoted, wound infection is inhibited, and compared with an existing formula, the effects are more comprehensive, and the effects are better. And pearls can be added according to requirements, so that the closing effect is further improved.