181results about How to "Drug stability" patented technology

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid-compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.

Drugs, especially low aqueous solubility drugs, are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aqueous media. The drug matrices preferably are made using a process that includes (i) dissolving a drug, preferably a drug having low aqueous solubility, in a volatile solvent to form a drug solution, (ii) combining at least one pore forming agent with the drug solution to form an emulsion, suspension, or second solution and hydrophilic or hydrophobic excipients that stabilize the drug and inhibit crystallization, and (iii) removing the volatile solvent and pore forming agent from the emulsion, suspension, or second solution to yield the porous matrix of drug. Hydrophobic or hydrophilic excipients may be selected to stabilize the drug in crystalline form by inhibiting crystal growth or to stabilize the drug in amorphous form by preventing crystallization. The pore forming agent can be either a volatile liquid that is immiscible with the drug solvent or a volatile solid compound, preferably a volatile salt. In a preferred embodiment, spray drying is used to remove the solvents and the pore forming agent. The resulting porous matrix has a faster rate of dissolution following administration to a patient, as compared to non-porous matrix forms of the drug. In a preferred embodiment, microparticles of the porous drug matrix are reconstituted with an aqueous medium and administered parenterally, or processed using standard techniques into tablets or capsules for oral administration.

A pharmaceutical preparation for the treatment of attention deficit disorders combines a therapeutically effective amount of digestive enzymes, such as chymotrypsin, and medication used to treat attention deficit disorders, such as Ritalin®, Concert®, Adderall® and Strattera®. The preparation may be in the form of a tablet, capsule or time released formula in order to reduce the amount of pills per dosage. The pharmaceutical preparation ameliorates the symptoms of the attention deficit disorder. The preparation has a stabilizing matrix containing a solidified microcrystalline cellulose which captures and protects therapeutically effective amounts of digestive enzyme particles within the stabilizing matrix.

The present invention provides aqueous oral formulations containing sertraline, or a pharmaceutically acceptable salt thereof, and a sulfoalkyl ether cyclodextrin. The liquid formulations are pleasant tasting, convenient to use, and chemically and physically stable. The liquid formulations can be administered directly or diluted before administration. Unlike the commercially available ZOLOFT™ formulation, the liquid formulations herein do not precipitate upon dilution with water, fruit juices, sodas or other pharmaceutically acceptable oral liquid carriers. The sulfoalkyl ether cyclodextrin-containing formulation provides significant advantages over the marketed non-aqueous formulation and other cyclodextrin-containing formulations of sertraline. The formulation can be self-preserved against microbial growth. The SAE-CD-containing formulation of sertraline can be provided in liquid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid formulations can be prepared. The formulation is available as a clear solution or a suspension.

The invention is to provide an electrode structure of an iontophoresis device and a method of producing the same, excellent in an economical property, an operational property, stability and safety. The electrode structure for the iontophoresis device comprises a backing having a substrate film (1) having a molding portion, an anode side and a cathode side electrode layers (14), (15) formed passing the outer circumferential portion from the inner bottom of the molding portion, and an insulating layer 3 formed in the outer circumferential portion of the molding portion. The molding portion of the backing has a dent portion and an anode side and a cathode side conductive layers (12), (13) are separately installed therein. A cover member (8) is installed to seal between these conductive layers (12), (13) and the insulating layer (3). An adhesive sheet (10) for attachment to the skin is provided to the rear face of the substrate film (1) and a liner (16) for the adhesive sheet is provided on the cover member (8).

The invention discloses the production method of an environmentally-friendly noble metal mineral processing reagent. The method comprises the following steps: putting potassium ferrocyanide and urea after being mixed into a reactor; adding a pH regulator during the slow temperature rise process; heating to the molten state; taking a small amount of molten material detection samples, cooling and dissolving into water; measuring the pH value, enabling the molten material pH value to be 8-14; keeping the molten temperature for 5-60 minutes; and cooling to the normal temperature, thus the environmentally-friendly noble metal mineral processing reagent is obtained. The product obtained from the invention can be widely applied to the production of noble metal mine, such as the soaking, core spray of gold oxide ores, silver oxide ores and copper oxide ores, also can be used in industrial production industries such as electroplating, and used as medicaments for replacing toxic Cymag; and compared with all the other non-toxic or low-toxicity mineral processing reagents, the noble metal mineral processing reagent has the advantages of good effect, stable drug property, environmentally-friendly product, simple production method, low cost and the like.

The invention discloses a Shaotangshang weinong shengji ointment and the preparing method thereof, prepared of the following Chinese medicinal drugs in the weight proportion: Rhizoma Coptidis, Baical Skullcap Root, weeping forsythia, Radix Arnebiae, Amur Corktree Bark, Liquorice Root, Dragon's Blood, Borneol, and Catechu Cutch 15-30g each, Giant Knotweed Rhizome, prepared Frankincense, Rhizoma Corydalis, prepared Myrrha, Mongolian Dandelion Herb, Rhubarb, Dahurian Angelica Root, and Tree Peony Bark 45-60g each, Chinese Angelica and Rehmannia Root 60-90g each, raw sesame oil 500-3000g, and beeswax 225-540g. And the preparing method: immersing these Chinese medicinal drugs but Dragon's Blood, Borneol, and Catechu Cutch in sesame oil for three days in the summer and for seven days in the spring, autumn and winter each; heating to boil at room temperature, then using slow fire to decoct until the Dahurian Angelica Root turns sallow; adding in beeswax and melting, and filtering out residues; before the filtrate solidifies, adding in the powdery Dragon's Blood, Borneol, and Catechu Cutch and uniformly blending, and 3-4 hours later, obtaining prunosus ointment; placing the pronosus ointment in a shady and cool and dry place and staying overnight, and obtaining the finished product after removing the fire poison.

The present invention discloses a novel anti-PD-L1 compound and applications thereof, and a composition containing the novel anti-PD-L1 compound, and provides a substituted biaryl compound representedby a formula I, a pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a stereoisomer, a tautomer or a prodrug thereof. The formula I is defined in the specification.

The present invention discloses an aromatic ring-containing compound and an application thereof, and provides an aromatic ring-containing compound represented by formula I, and a pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a stereoisomer, a tautomer or a prodrug thereof. The compound I provided by the invention has the advantages of high activity, high bioavailability, stable drug, and oral administration.

The invention discloses a gold and silver leaching agent prepared from cyanate. The gold and silver leaching agent is characterized in that low-valence iron or low-valence iron salt is mixed with the cyanate at the weight ratio of 1:(2-50) to obtain the leaching agent. The invention also discloses a using method of the leaching agent. The method comprises the following steps of (1) adding the gold and silver leaching agent into ores or fine ores, wherein 100 to 5000 grams of gold and silver leaching agent is added into every ton of ores or fine ores; (2) adjusting the pH value of ore pulp to be more than 9.5; (3) adding a proper amount of water to regulate the concentration of the ore pulp to be 15 to 70 percent; (4) stirring the ore pulp for 10 to 30 hours; (5) recovering gold and silver. The gold and silver leaching agent can be widely applied to the production of a noble metal mine; the leaching agent can dissolve gold and silver, and form a complex with gold and silver ions to facilitate the dissolution of gold and silver; the leaching agent and the method can also be used in the industrial production industries of electroplating and the like to replace chemicals with toxic sodium cyanide; compared with all other nontoxic or low-toxicity beneficiation chemicals, the leaching agent has the characteristics of good effects, stable potency, environmental friendliness, simplicity of a production method, low cost and the like.

The invention relates to a medicine for treating burns and scalds, in particular to a burn and scald cooling and pain-relieving ointment for treating burns and scalds and a preparation method thereof. The raw materials of the burn and scald relieving pain ointment of the present invention include coptis, scutellaria baicalensis, cold water stone, raw burnet, raw rhubarb, cortex cortex, knotweed, borneol, sesame oil and beeswax. The preparation steps of the cool and pain-relieving ointment for burns and scalds of the present invention are as follows: (1) weighing raw materials; (2) soaking Coptidis rhizome, Scutellaria baicalensis, Hanshui stone, raw Burnet, raw rhubarb, Cortex Phellodendron and Polygonum cuspidatum in sesame oil; (3) soaking Put the mixed solution into the container and heat it to boiling with a stove, then change to low heat and boil the rhubarb rhizome, scutellaria baicalensis, raw Burnet, raw rhubarb, Cortex Phellodendron and Polygonum cuspidatum to dry up and suspend; (4) Add beeswax to the container, melt and filter to remove slag; (5) Add borneol to the filtered mixture and stir evenly, and it will become a light yellow ointment after 3 to 4 hours; (6) Put the ointment in a cool place overnight, and after detoxification, the finished product of burn and scald cooling pain relief ointment is obtained .

The invention relates to a method for preparing vital wheat gluten flour, and belongs to processing methods of edible protein. The method comprises the following steps: a. adding water to wheat flour to be made into flour dough; b. naturally curing and washing the flour dough with the water to obtain a gluten flour clot; and c. freezing and drying the gluten flour clot to obtain the vital wheat gluten flour, wherein, the freezing temperature is minus 5-minus 6 DEG C, and the freezing time is 8-10 hours.

An antihypentenssive Chinese medicine for treating hypertension is prepared from 5 Chinese-medicinal materials including eucommia bark, motherwort, prunella spike, scutellaria root, etc through mixing and extracting.

This invention relates to a new pharmaceutical formulation of voriconazole, in particular a formulation comprising one or more poloxamers.

The invention relates to a medicine for curing hyperthyroidism and a method of preparing the medicine. The medicine is composed of 10 to 40 portion of fresh yam, 10 to 40 portion of raw oyster, 10 to 40 portion of fortune's drynaria rhizome, 10 to 40 portion of milkvetch root, 10 to 40 portion of pumice, 10 to 40 portion of climbing groundsel herb, 10 to 40 portion of spicaprunellae, 10 to 40 portion of sargassum, 10 to 40 portion of thallus eckloniae, 10 to 40 portion of white mustard seed, 5 to 20 portion of thunberg fritillary bulb, 5 to 20 portion of tuber pinelliak, 5 to 20 portion of angelica, 5 to 20 portion of ampelopsis japonica, 5 to 20 portion of pipewort, 5 to 20 portion of tangshen, 5 to 20 portion of trigone, 5 to 20 portion of rhizoma zedoariae, 2 to 8 portion of cyclophosphamide and 0.3 to 1 portion of tapazole by the weight percent, which are processed through a series of procedures, including medicine selection, drying arrow crushing, sifting arrow sterilization arrow preparation and packaging. The invention is characterized by quick effect, short period of treatment, high therapeutic effect, little toxicity and side effect, convenience in being taken and prevention of recurrence, etc.

A gasket insertion method for inserting a gasket into an outer cylinder includes providing an outer cylinder having a base end opening section; providing a gasket having a recessed section that is open at a base end of the gasket and that includes a flat bottom surface; pushing the gasket into a sleeve configured to be inserted into the outer cylinder, by relatively moving an inserter in a tip end direction with respect to the sleeve while a flat tip end surface of a tip end section of the inserter abuts the bottom surface of the recessed section; inserting the sleeve into the outer cylinder through the base end opening section; and arranging the gasket inside the outer cylinder by relatively moving the sleeve in a base end direction with respect to the outer cylinder while maintaining relative axial positions of the outer cylinder, the gasket, and the inserter.

The invention discloses traditional Chinese medicine health tea and a manufacturing method. The manufacturing method comprises the following steps: firstly, Tieguanyin Tea is soaked and boiled in a liquor composed of ganoderma lucidum, radix codonopsitis, poria, atractylodes macrocephala and hoantchy roots; after the liquor is absorbed completely, the Tieguanyin Tea is changed into Tieguanyin Tea added with herbal medicines through baking; finally, xanthium sibiricum seeds, didiplis diandra, radix glycyrrhizae and anoectochilus roxburghii are added in a matching manner, so that the processing of the bagged traditional Chinese medicine health can be finished. The method achieves the purpose of perfectly combining tea drinking and health preserving of traditional Chinese medicine; the manufactured traditional Chinese medicine health tea is long in preservation time and convenient to use, has the efficacy of clearing away heat and toxic material, nourishing and protecting the liver, alleviating a hangover, reducing internal heat and eliminating cold, and is particularly suitable for people who have deficiency-cold in spleen and stomach or have internal heat at the throat.

A pharmaceutical preparation for the treatment of attention deficit disorders combines a therapeutically effective amount of digestive enzymes, such as chymotrypsin, and medication used to treat attention deficit disorders, such as Ritalin®, Concerta®, Adderall® and Strattera®. The preparation may be in the form of a tablet, capsule or time released formula in order to reduce the amount of pills per dosage. The pharmaceutical preparation ameliorates the symptoms of the attention deficit disorder. The preparation has a stabilizing matrix containing a solidified microcrystalline cellulose which captures and protects therapeutically effective amounts of digestive enzyme particles within the stabilizing matrix.

The present invention relates to a Chinese medicine for effectively curing arthrosis and its preparation method. Said preparation method includes the following steps: mixing all the medicinal raw materials according to a certain weight mixing ratio, placing them into an earthenpot, successively and respectively adding 3kg, 2.5kg and 2kg of water to decocte them for three times, every time is 30min, filtering to respectively obtain three medicine liquors, mixing three medicine liquors together and placing them into an earthenpot, boiling to obtain a viscous medicine liquid, drying and removing water content to obtain dried medicine product, then placing the dried medicine in a container, adding pure alcohol until their weight is 1kg, uniformly mixing them so as to obtain the invented finished product liquid medicine for external application. It can be effectively used for curing the diseases of rheumatic arthritis, rheumatoid arthritis, necrosis of femoral head, ankylosing spondylitis, prolapse of lumbar intervertebral disk, hyperosteogeny, sciatica, cervical spondylopathy, scapulohumeral periarthritis, painful heels and affection by cold after delivery, etc. with obvious therapeutic effect.

The invention discloses an intelligent medicine delivering robot comprising a robot body, a medicine containing box arranged on the top of the robot body, a mechanical arm mechanism, a driving mechanism and a control mechanism, wherein the mechanical arm mechanism is used for identifying medicine information, grabbing the identified medicine and placing the medicine into the medicine containing box, one end of the mechanical arm mechanism is installed on the top of the robot body, the drive mechanism is used for driving the robot body to move to a preset position of a patient, the drive mechanism is connected with the robot body, and the control mechanism is used for providing movement path navigation and guide for the drive mechanism, arranged in the robot body and connected with the drive mechanism. Compared with the traditional technology, the intelligent medicine delivering robot is reasonable in design, simple in structure, convenient to use and capable of replacing medical staffto conduct accurate positioned matched medicine delivery to the patients, so that the work burden of the medical staff is lightened, and the operation efficiency of the hospital is improved beneficially.

The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin / rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.

The invention discloses a medicine for eliminating phlegm and stopping cough, relieving dyspepsia and activating blood and dissolving stasis and a preparation method thereof. The medicine is a sugarless seabuckthorn granule made up of a seabuckthorn extract (a solid matter), mannite, dextrine, soluble starch and steviosin. The medicine has advanced production technique, good drug effect, low dosage, and is convenient for taking and carrying. In addition, the medicine solves the problems on drug taking for patients with diabetes, obesity, cardiovascular diseases and decayed tooth, and obtains unexpected effects.

The invention discloses medicinal liquor for strengthening bone and a preparation method thereof. The medicinal liquor for strengthening bone contains sheep tibia, sheep kidney, cinnamon, medlar, zaocys dhumnades and white spirit. The preparation method for the medicinal liquor for strengthening bone comprises the following steps of: adding cinnamon, medlar, and zaocys dhumnades into sheep tibia lyophilized powder and sheep kidney lyophilized powder, putting a mixture into a cloth bag, putting the cloth bag into a container, adding wine into the container, covering, and heating the container over fire for more than 10 minutes, keeping the container away from the fire, cooling, sealing for immersing for more than 3 days, and shaking everyday and filtering dregs out to obtain the medicinal liquor for strengthening bone. The medicinal liquor is convenient to prepare, stable in medicinal property, and safe and effective; the effect of the medicinal liquor is achieved through the mutual effect of the white spirit and medicines; the curative effect is improved; the medicinal liquor is used for treating wind-toxin and waist and knee weakness which are caused by liver-kidney deficiency, and exogenous and endogenous pathogenic factors, patients who suffer from pain, swelling, and stiffness of shoulders, backs and limbs and have symptoms of rheumatic arthritis, rheumatoid arthritis, and senile degenerative osteoarthritis or patients who suffer from arthralgia, swelling and stiffness after trauma and bone fracture; and the medicinal liquor for strengthening bone can address both the symptoms and root causes, and does not have toxic or side effects; and after the medicinal liquor for strengthening bone is taken by patients, disease relapse is prevented.

The invention provides an induction method of callus of a sterile seedling prepared from the root bud of Amomum villosum Lour. The induction method comprises the following steps: taking the sterile seedling of the root bud of the Amomum villosum Lour. as an explant, sterilizing, inoculating and performing induction culture to obtain the callus, wherein an induction medium for induction culture isMS+1.0 to 2.5 mg / L 6-BA+0.5 to 1.5 mg / L 2,4-D+0.5 to 1.5 mg / L NAA; the illumination time of a culture environment is 10 h, the light intensity is 2000 Lx, and the culture temperature is 25 DEG C. Thestem and the root tip of the sterile seedling of the rhizome of the Amomum villosum Lour. Are used as the explant, and the asexual reproduction can retain the complete medicinal properties of a parent, and variation is not easy to generate, thereby making the medicine property stable and ensuring the effect of the drug treatment, and the explant material is easy to obtain and can be taken at any time for breeding culture.

The invention provides a cinnamaldehyde nanoemulsion bacteriostatic agent and a preparation method thereof. The cinnamaldehyde nanoemulsion bacteriostatic agent takes 0.9-1.2% of cinnamaldehyde as an antibacterial ingredient and is prepared into nanoemulsion from 9-10% of surfactants, 4-5% of cosurfactants, 11-13% of oil and water, thereby being excellent in water solubility and making use of the cinnamaldehyde for preventing and controlling pathogenic microorganisms in a water body possible. Compared with the prior art, the cinnamaldehyde nanoemulsion bacteriostatic agent and the preparation method thereof have the advantages that environmental pollution caused by use of antibiotics and chemical disinfectants can be avoided; the cinnamaldehyde nanoemulsion bacteriostatic agent has good bacteriostatic and bactericidal effects, and pathogenic bacteria are less prone to production of drug tolerance; the preparation method is simple, net content of the cinnamaldehyde is high, quality of the cinnamaldehyde is stable, and accordingly, the cinnamaldehyde nanoemulsion bacteriostatic agent is suitable for large-scale production; the cinnamaldehyde nanoemulsion bacteriostatic agent, which is soluble in water and stable in property after dissolving in water, can be widely applied to disinfection of an aquaculture pond water body and prevention and control of common aquaculture fish pathogenic bacteria.

The invention discloses a traditional Chinese medicine thread for treating sore and ulcer diseases and a preparation method thereof. The traditional Chinese medicine thread is formed by dipping and attaching the following raw materials in parts by weight on a medical thread: 8-4 parts of roots of lilac daphne, 5-1 part of brucea javanica kernel, 5-1 part of croton seed, 5-1 part of Uroctea charcoal, 5-1 part of charred schizonepeta and 8-4 parts of dragon's blood. When the traditional Chinese medicine thread is used in clinic, the acute and chronic stages of sore and ulcer diseases are effectively considered, and the traditional Chinese medicine thread has the composite treatment effects of removing necrotic tissues, detoxifying, expelling pus, stopping bleeding, astringing and promoting tissue regeneration.

The present invention discloses a substituted phenyl compound and an application thereof, and provides a substituted phenyl compound represented by formula I, or pharmaceutically acceptable salt, a hydrate, a solvate, a metabolite, a stereoisomer, a tautomer or a prodrug thereof. The compound I provided by the invention has the advantages of high activity, high bioavailability, stable drug and oral administration.

The invention discloses a preparation and production method for medicinal liquor and belongs to the technical field of production process methods for the medicinal liquor which has the effects of treating diseases, preventing diseases, protecting health and the like. The preparation method comprises the following steps of: placing 500g of notoginseng root and 150g of safflower in a container, adding 1,000g of homemade 60-degree rice wine, soaking for 30 to 40 days, filtering, adding 5g of borneol, stirring uniformly to prepare the externally applied medicinal liquor. The invention has the advantages that: the externally applied medicinal liquor is quick in response, does not have side effects and reduces medical cost of patients, and the total effective rate is about 98 percent.

The present invention discloses a traditional Chinese medicine health preserving tea which is made from the following raw materials in parts by weight: 8-15 parts of wild chrysanthemums, 7-11 parts of Chinese wolfberry fruits, 2-6 parts of black beans, 15-20 parts of radix puerariae, 6-13 parts of salvia miltiorrhiza, 3-7 parts of poria cocos, 7-15 parts of panax notoginseng, 1-5 parts of lysimachia christinae, 1-4 parts of thlaspi arvense, 2-6 parts of solanum lyratum, 7-12 parts of herba hedyotidis diffusae, 3-9 parts of radix anemones rivularis, 15-25 parts of pu'er tea, 5-10 parts of honey, 3-8 parts of red dates, and 1-5 parts of crystal sugar. The various traditional Chinese medicines are matched with the pu'er tea for drinking, which is a perfect combination of drinking tea and health-care and body preserving traditional Chinese medicines. The prepared traditional Chinese medicine health preserving tea is long in preservation time, is easy to use, is gentle in medicine properties, is accurate in dosage, has efficacies of clearing heat and clearing away toxins, nourishing and protecting liver, dispelling alcoholism, soothing liver and strengthening spleen, and removing fire and dispelling cold, and can improve hepatic microcirculation, promote metabolism of liver to alcohol, medicines, and poisons, eliminate dizziness, fatigue, nausea, liver discomfort and other symptoms of people working overtime and late at night, and regulate and promote liver health in a long-term drinking.

The present invention relates to a composition for inhibiting after-cataract including a hydrophilic sulfasalazine; a high content of hyaluronic acid; and a carrier containing an aqueous solution, and a method of preparing a composition for inhibiting after-cataract including the steps of adding hyaluronic acid powder to a hydrophilized sulfasalazine; and mixing the same with a specific condition.