69 results about "DISEASE RELAPSE" patented technology

The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.

The use of anti-CD20 antibodies as in vivo purging agents for patients receiving bone marrow or peripheral blood stem cell transplant during treatment of B-cell-related diseases, e.g., B-cell lymphomas or leukemias, is disclosed. Such purging may enhance engraftment and/or prevent disease relapse in such patients.

Patients who develop increased numbers of γδ+ cytotoxic T lymphocytes 2–6 months after allogeneic bone marrow transplantation are less likely to relapse than those who do not. The γδ+ T cells isolated from blood of patients with increased γδ+ T cells are CD3+CD4−CD8−CD57+, cytolytic to K562 cells, and express the Vδ1 T cell receptor phenotype. Similar γδ+ T cells can be generated in vitro by culture of donor mononuclear cells which are enriched for γδ+ T cells by immunomagnetic depletion of depleted of CD4+ and CD8+ cells. This γδ-enriched cell preparation was cultured on a combination of immobilized pan-δ monoclonal antibody and irradiated recipient B cell leukemia. After four weeks, the cultures were almost exclusively Vδ1+CD3+CD4−CD8− cells that co-expressed activation-associated antigens CD69, CD25, and HLA-DR. Furthermore, they were cytolytic against the primary leukemia obtained from the recipient and lymphoblastic leukemia cell lines, yet had minimal cytotoxicity against normal donor-derived mononuclear cells or myeloid leulemia cell lines. These observations suggest that donor-derived cytotoxic γδ+ T cells can be generated in vitro, and may provide therapeutic potential for prevention of disease relapse.

The invention provides an aortic dissection aneurysm covered stent which comprises a cylindrical metal supporting portion and a cylindrical covered portion coated on the cylindrical metal supporting portion. A bulging covered portion is coated outside the cylindrical covered portion, and the middle portion of the bulging covered portion bulges outwards. By adopting the above structure, a false lumen crevasse can be sealed and isolated, space of a false lumen can be actively reduced, blood flow speed and blood flow in the false lumen can be changed, and the false lumen is ensured to quickly form thrombus within expected time; the outwards-bulging portion can effectively prevent displacement and sliding caused by blood flow impact after the stent is implanted in a human body, and disease relapse caused by exposure of an original aortic crevasse due to displacement of the stent is avoided.

The present invention provides a method for treating patients with liver diseases by co-administrating a pharmaceutical composition and lamivudine to the patients. The pharmaceutical composition is a herbal mixture which contains, as the core ingredients, the aqueous extracts of the entire plant of Herba Hedyotidis diffusae, the rhizome of Rhizoma Bistortae, the rhizome of Rhizoma Polygoni Cuspidati, and the ripe fruit of Fructus Schisandrae. The present invention also provides methods for preventing a relapse of hepatitis in patients after the lamivudine treatment has been discontinued and for suppressing the development of lamivudine drug resistance in patients by providing the lamivudine-treated patients with the pharmaceutical composition of the present invention.

The invention discloses medicinal liquor for strengthening bone and a preparation method thereof. The medicinal liquor for strengthening bone contains sheep tibia, sheep kidney, cinnamon, medlar, zaocys dhumnades and white spirit. The preparation method for the medicinal liquor for strengthening bone comprises the following steps of: adding cinnamon, medlar, and zaocys dhumnades into sheep tibia lyophilized powder and sheep kidney lyophilized powder, putting a mixture into a cloth bag, putting the cloth bag into a container, adding wine into the container, covering, and heating the container over fire for more than 10 minutes, keeping the container away from the fire, cooling, sealing for immersing for more than 3 days, and shaking everyday and filtering dregs out to obtain the medicinal liquor for strengthening bone. The medicinal liquor is convenient to prepare, stable in medicinal property, and safe and effective; the effect of the medicinal liquor is achieved through the mutual effect of the white spirit and medicines; the curative effect is improved; the medicinal liquor is used for treating wind-toxin and waist and knee weakness which are caused by liver-kidney deficiency, and exogenous and endogenous pathogenic factors, patients who suffer from pain, swelling, and stiffness of shoulders, backs and limbs and have symptoms of rheumatic arthritis, rheumatoid arthritis, and senile degenerative osteoarthritis or patients who suffer from arthralgia, swelling and stiffness after trauma and bone fracture; and the medicinal liquor for strengthening bone can address both the symptoms and root causes, and does not have toxic or side effects; and after the medicinal liquor for strengthening bone is taken by patients, disease relapse is prevented.

The present invention is directed to methods for detecting a colon cancer, methods for determining whether a colon cancer is stable or progressive, methods for determining a risk for disease relapse, and methods for determining a response by a subject having a colon cancer to a therapy.

The invention relates to the technical field of pesticides, in particular to a single or compound oligochitosan preparation and an application of the single or compound oligochitosan preparation in tomato virus disease control. Tomato virus diseases are controlled by separately applying an aqueous oligochitosan solution or adding one or more of biocontrol bacteria and/or organic fertilizer, inorganic fertilizer and inorganic compound fertilizer to oligochitosan, and the problems of low virus control rate, disease relapse and pesticide residue existence of a conventional chemical pesticide for controlling the tomato virus diseases are solved. The required oligochitosan has an abundant source, has the characteristics of microscale, high efficiency, low cost and avoidance of environment pollution in agriculture, is different from a traditional biological pesticide and chemical pesticide in the aspect of plant regulation and control effect, can promote crop growth, improve crop quality and induce plant disease resistance, produces immunizing and killing functions on multiple fungi, bacteria and viruses, and is very suitable for industrial mass production.

The invention relates to the technical field of medical apparatus, in particular to a minimal-invasion surgical fetching system capable of smashing a specimen by pneumoperitoneum, and the system can take out an internal bulk-mass-lesion excised tissue during a surgery. The system includes a fetching bag device, the fetching bag device includes a bag body, a bag opening of the bag body is provided with an extendable ring, and the system further includes a sealing cover matched with the extendable ring, an air-inflation device for inflating the bag body and a smashing device for smashing pathological tissues. An air inflation channel for the air inflation device and a smashing channel for the smashing device are arranged on the sealing cover, air seal is conducted between the air inflation channel and the air inflation device, and the air seal is conducted between the smashing channel and the smashing device. The fetching system capable of conducting rotary cutting on foreign matters by pneumoperitoneum can take out bulk-mass pathological tissues from smaller incisions, and internal residual pathological tissues are avoided. The fetching system is safe and reliable, and reduces the risk of disease relapse of patients.

A diagnostic assay for cancer such as lung cancer is disclosed. The assay can also be used to follow patients during treatment and for assessment of disease relapse after treatment. The assay utilizes biomarkers for tumor formation identified in a transgenic mouse model. The assay is used to identify a therapeutic indication for a patient based on the patient's biomarker expression. The biomarker and fragments thereof are also useful for treating cancer, for example lung or colon cancer.

The invention relates to a single-sided bacterial cellulose/polypropylene composite sticking patch suitable for intra-abdominal repair and a preparation method of the single-sided bacterial cellulose/polypropylene composite sticking patch. The single-sided bacterial cellulose/polypropylene composite sticking patch is a double-layer sticking patch with a bacterial cellulose layer and a polypropylene layer, and the preparation method comprises the following steps: floating sterilized polypropylene meshes on the surface of a bacterial cellulose culture solution, standing for compound culture 3-5 days, then taking out a fermentation product, and treating the fermentation product by using chemical reagents of acids, alkalis and the like to obtain the single-sided bacterial cellulose/polypropylene composite sticking patch for repairing abdominal wall coloboma. According to the composite sticking patch provided by the invention, the bacterial cellulose layer serving as an abdominal cavity surface is good in biocompatibility and can reduce adhesion of abdominal internal organs; and the polypropylene layer serving as an abdominal wall surface can be firmly fixed with an abdominal wall by virtue of adhesion with the abdominal wall, thereby ensuring the repairing effect and reducing the disease relapse rate.

The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by atherosclerosis. The method may be used for classification of individuals in order to optimize treatment or monitoring the individuals during the course of or prior to or after treatment. The individual may suffer from any type of cardiovascular disease or disorder. The method also detects and determines whether diagnostically or prognostically significant levels of YKL-40 molecules are present in a biological sample. Furthermore the level of YKL-40 may be used to predict disease relapse.

The invention discloses a physique diagnosis and treatment system. The system comprises a diagnosis module (1) and a treatment module (2); the treatment module (2) is provided with a computer diagnosis and treatment terminal (3); the computer diagnosis and treatment terminal (3) is provided with an operation and storage chip, an input device and an output device; the operation and storage chip stores disease treatment software and personal health data; the diagnosis module (1) is provided with a sphygmomanometer (4), a glucometer (5), a weight monitor (6) and a body temperature monitor (7). Bythe adoption of the technical scheme, the computer network technology is utilized, the disease diagnosis and treatment level is comprehensively improved, overall adjustment is carried out from the perspective of physique, intervention measures can be actively taken from the early stage of diseases, and the diseases are avoided to the largest extent; root causes can be found according to physiquecharacteristics after diseases occur, physique conditioning is carried out on the basis of symptomatic treatment, the diseases are avoided to the greatest extent, the diseases do not develop, and disease relapse is avoided.

The invention discloses a bionic rehabilitation wheelchair with physiological monitoring, comprising: a medical locator, a physiological monitoring module, a route guidance module, a drive control mechanism, an alarm module and a control module. In the present invention, the setting of the medical locator lays the foundation for the patient and wheelchair user to locate the responsible doctor in real time, which is helpful for the wheelchair user to find the responsible doctor in time for help when the condition of the wheelchair user turns urgent, thereby avoiding the risk of accidents. In the present invention, through the combination of the route guidance module and the drive control mechanism, the wheelchair can automatically find the responsible doctor, thereby ensuring that the wheelchair user can receive timely diagnosis and treatment in the case of repeated illnesses, and ensure life safety.

The invention discloses a meningeoma nursing medicine and a preparation method thereof. The nursing medicine is a formula formed by combining traditional Chinese medicine and western medicine, wherein the western medicine comprises the following components: dichloro diethylamine, cyclophosphamide, ifosfamide, melphalan, chlorambucil, thiotepa, mitomycin, busulfan, lomustine, carmustine, temozolomide and carboplatin. The traditional Chinese medicine comprises the following components: Oldenlandia diffusa, dangshen, honey-fried licorice root, fructus forsythiae, realgar, edible tulip, Schisandra chinensis, ginseng, soroseris, beautyberry leaf, radix curcumae, hawthorn, pheretima, gastrodia elata, Minoru thorns, Rehmannia Glutinosa, Ligusticum wallichii, Angelica sinensis, Polygonum cuspidatum, bamboo leaf, radix semiaquilegiae, red flower, white paeony root, pubescent holly root, fried monkshood, herba eupatorii, ambergris, fingered citron, Radix Aucklandiae, radix scutellariae, radix bupleuri and serrate rabdosia herb; the meningeoma nursing medicine has the advantages of obvious treatment effect, low disease relapsing rate and low side effect.

The invention provides an intelligent respiratory disease diagnosis and treatment system and a method for controlling and applying the same. The intelligent respiratory disease diagnosis and treatmentsystem comprises a server. The server comprises one or a plurality of processors. The processors are configured for executing computer program modules. The intelligent respiratory disease diagnosis and treatment system is characterized in that the computer program modules include a diagnosis publishing system module, an asthma management scheme execution system module and a user equipment accessauthentication system module. The intelligent respiratory disease diagnosis and treatment system and the method have the advantages that respiratory disease diagnosis/treatment schemes and treatment scheme execution are seamlessly connected with one another, accordingly, positive feedback and loop of (doctor) diagnosis -> treatment (patient self-management) and treatment (patient self-management)-> (doctor) diagnosis can be implemented during asthma disease treatment, the control and cure efficiency can be improved, and disease relapse and even deterioration due to asthma self-management failures can be prevented.

The invention discloses a Chinese medicinal composition for treating postpartum lochiorrhagia of dairy cattle. The Chinese medicinal composition comprises the following Chinese medicinal raw materials in part by weight: 50 parts of szechuan tangshen root, 30 parts of bupleurum, 30 parts of largetrifoliolious bugbane rhizome, 60 parts of white paeony root, 45 parts of rehmannia root, 25 parts of baical skullcap root, 25 parts of phellodendron, 25 parts of notoginseng root, 25 parts of dragon's blood, 25 parts of root of red-rooted salvia, 25 parts of motherwort herb, 65 parts of raw hawthorn fruit, 25 parts of tangerine peel and 10 parts of liquoric root, and is prepared from the following Chinese medicinal raw materials in part by weight: 80 parts of astragalus, 50 parts of szechuan tangshen root, 30 parts of bupleurum, 30 parts of largetrifoliolious bugbane rhizome, 60 parts of white paeony root, 45 parts of rehmannia root, 25 parts of baical skullcap root, 25 parts of phellodendron, 25 parts of root of red-rooted salvia, 25 parts of motherwort herb, 65 parts of raw hawthorn fruit, 25 parts of tangerine peel and 10 parts of liquoric root. The invention has the advantages that: the Chinese medicinal composition is convenient to take, low in treatment cost, wide in medicinal sources and cheap in price and has an obvious curative effect, disease relapse is prevented after patients are cured, the effective rate of and the cure rate of the Chinese medicinal composition treating the postpartum lochiorrhagia of dairy cattle are 100 percent.

The invention discloses a traditional Chinese medicine pill for treating intracranial tumor-induced epilepsy, belonging to the technical field of traditional Chinese medicine and pharmacy. According to the prescription, the pill is prepared from carefully selected traditional Chinese herbal medicines with effects of diminishing swelling, suppressing tumors, relieving dizziness, dredging collaterals and relieving convulsion and is particularly prepared from the following traditional Chinese medicinal raw materials in parts by weight: 10-15 parts of gastrodia elata, 15-30 parts of semen lepidii, 15-30 parts of scorpio, 15-30 parts of centipedes, 6-10 parts of euphorbia kansui, 4-10 parts of borneol, 15-30 parts of ground beetles, 10-15 parts of arisaema cum bile, 6-10 parts of kaladana and 4-10 parts of cinnamon. Lots of clinical observations prove that the pill has a remarkable curative effect on brain-tumor secondary epilepsy. Compared with Western medicines, the traditional Chinese medicine pill disclosed by the invention has the advantages of high treatment effective rate and stable and long-lasting effect, low disease relapse rate; and the pill does not need to be taken any more after being taken for 2-6 courses of treatment and has a low toxic and side effect.

The invention relates to the technical field of medicines, in particular to a medicine for treating proliferation of the mammary gland. The medicine comprises, by weight, 50-95 parts of uniflower swisscentaury roots, 70-130 parts of cluster mallow fruits, 40-60 parts of chinese rose flowers, 65-90 parts of tribulus terrestris, 45-85 parts of polygala amflra, 50-100 parts of concha meretricis seu cyclinae, 30-60 parts of chlorite schist, 100-200 parts of indian rorippa herb, 60-90 parts of rhizoma cyperi, 30-50 parts of longstamen onion bulb, 40-80 parts of radix aristolochiae, 50-90 parts of campsis grandiflora, 10-50 parts of garden balsam, 40-80 parts of gastrodin, 70-120 parts of phillyrin, 70-120 parts of lilies, 60-120 parts of fructus lycii, 80-150 parts of lotus seeds, 20-60 parts of sanchi flowers, 150-250 parts of bananas and 150-250 parts of grapes. The medicine can cure the symptoms of proliferation of the mammary gland, also can prevent disease relapse fundamentally, is remarkable in treatment effect, and can be easily absorbed by a human body. Clinic tests show that the total effective rate of the medicine reaches 100%.

The invention discloses a pure traditional Chinese medicinal formula for treating intractable respiratory diseases of sows and piglets. The pure traditional Chinese medicinal formula comprises, by weight, 20-25g of codonopsis pilosula, 25-40g of licorice roots, 25-50g of honeysuckles, 30-40g of astragalus membranaceus, 15-20g of scutellaria baicalensis, 20-30g of coptis chinensis, 25-40g of radix ophiopogonis, 30-50g of hawthorn fruits, 20-40g of ligusticum wallichii, 30-50g of fructus forsythia, 20-40g of white peony roots and 10-30g of cortex phellodendri. The pure traditional Chinese medicinal formula has the advantages of non-existence of antibiotics, high efficiency, economy, comprehensive treatment, non-existence of side effects, and ultralow disease recurrence rate or non-existence of disease recurrence.

The invention discloses a foot exercising machine for removing the dead skin and enhancing the skin tolerance of the surface of the foot palm and a using method of the foot exercising machine. The foot exercising machine comprises a vibration plate, a refrigerating device, a polarization device, a hanging structure, an ultraviolet irradiation device and an infrared sterilization device, wherein the vibration plate is used for supporting the feet, and the infrared sterilization device is used for killing out pathogenic bacteria. The metal vibration plate is paved with screened natural sand grains. The refrigerating device is used for enabling the vibration plate and the sand grains to keep low temperature through circulating water cooling or semiconductor refrigerating or compressor refrigerating. The polarization device and the spring bearing type vibration plate hanging structure are installed on the bottom portion of the vibration plate. A driving motor of the polarization device is stepless speed regulating motor. The ultraviolet irradiation device is installed on the lower portion of the left side of the vibration plate. The infrared sterilization device is installed on the upper portion of the left side of the vibration plate. The capacity of the human body for resisting the foot skin disease relapse is improved, the foot exercise machine is an effective foot exercising device without the side effect, and the remarkable foot health state improving effect can be brought to people in tepidity moist regions.

The invention provides traditional Chinese medicine composition for treating diabetic peripheral neuropathy during foot bath. The traditional Chinese medicine composition comprises raw materials as follows: ramulus cinnamomi, folium artemisiae argyi, Chinese angelica, asarum, angelica dahurica, liquorice, radix cyathulae, flos carthami, centipedes, notopterygium incisum, stigma maydis, dandelion, forsythia suspense, rhizome curcumae, medicinal Indianmulberry roots, herba ecliptae, ampelopsis japonica, semen euryales, moutan barks, portulaca oleracea, radix polygoni multiflori and polygonum cuspidatum sieb. Selected medicines of the traditional Chinese medicine composition are compatible, compatibility of the medicines accords with traditional Chinese medicine and modern medicine and pharmacology theories and accords with the sovereign, minister, assistant and courier principle of traditional Chinese medicine, the traditional Chinese medicine composition is safe and effective in treatment of diabetic peripheral neuropathy, liquid medicine can be directly absorbed, the course of the disease can be shortened obviously, the pain is relieved, and meanwhile, the traditional Chinese medicine composition has the health-care functions of body strengthening and disease relapse preventing.

The invention discloses a traditional Chinese medicine composition for treating a liver-kidney deficiency type motor neuron disease. The traditional Chinese medicine composition is prepared from the following raw medicines: codonopsis pilosula, Chinese yam, human placenta, astragalus membranaceus, angelica sinensis, prepared rhizome of rehmannia, dogwood, rhizoma curculiginis, the bark of eucommia, herba cistanche, semen allii tuberosi, dendrobe, the root of bidentate achyranthes, eclipta, tortoise shell, polygonum multiflorum, stellariayunnanensis Franch, raspberry, mulberry, flatstem milkvetch seed, chicken liver, magnetite, Chinese photinia leaf, caulis spatholobi and liquorice. The traditional Chinese medicine composition disclosed by the invention has the effects of nourishing liver and kidneys, nourishing yin and clearing away heat and is mainly used for treating long-term yin deficiency affecting yang caused by the liver-kidney deficiency type motor neuron disease. Prepared from the traditional Chinese medicinal materials with different properties according to a rigorous formula, the traditional Chinese medicine composition plays a direct effect on a focus of infection, and is short in healing period, good in curative effect and less in disease relapse possibility after the disease is cured; moreover, the traditional Chinese medicine composition is simple and convenient to prepare in a preparation process, small in toxic and side effects and convenient to take; the medicament is easy to prepare and low in cost.