1335 results about "Virus diseases" patented technology

The invention discloses an anti-SARS-CoV-2 fully-humanized monoclonal antibody against SARS-CoV-2. The antibody is obtained by screening through a flow sorting-single cell PCR technology, and has a unique CDR partition. The invention further discloses an application of the antibody in preparation of medicines for treating the 2019-coronavirus disease. The monoclonal antibody disclosed by the invention has efficient and specific anti-SARS-COV-2 activity, also has the characteristics of high expression, complete humanization and good stability, and is suitable for industrial production.

The present invention relates to a pentacyclic triterpanoid derivative of multiple-oxide substitution of the A ring and the C ring and the medicine salt or solvate of the derivative, and the present invention also relates to the preparation method, the drug combination, and medical use of the derivative. The compound of the present invention has the functions of inhibiting the activity of six human tumor cell strains in vitro, such as human prostate cancer cell (PC-3), nasopharyngeal carcinoma cells (CNE), oral squamous carcinoma cell(KB), human lung cancer cell (A549), human hepatoma cell (BEL-7404), and human cervix cancer cell (Hela), and the function of the invention is at the same magnitude of the positive control of cisplatin, thereby the compound can be used as expected antitumor drug. The compound of the present invention also inhibits the alpha glucosidase strongly, and the inhibiting effect is greater than the positive control of acarbose, thereby the compound can be used as expected medicine for preventing and treating diabetes and the treatment of the virus diseases.

The invention relates to a pesticide composition for relieving the phytotoxicity of herbicide. Effective components are a plant growth regulating agent and active polysaccharide, wherein the plant growth regulating agent is any one or a mixed agent of two of compound nitrophenolate and diethylaminoethyl hexanoate; the active polysaccharide is any one or a mixed agent of two of chitosan oligosaccharide and poly-glucosene; and the pesticide composition comprises the effective components in parts by weight of 0.05-90.0 parts of the plant growth regulating agent and 0.05-90.0 parts of the active polysaccharide. The pesticide composition comprehensively utilizes the synergism effect of the plant growth regulating agent and the active polysaccharide to resist disease source force and relieve the phytotoxicity of the herbicide. The pesticide composition is further applicable to crop exogenous damages including hormone phytotoxicity, low-temperature frozen injury, salt alkaline injury and the like, and also can be used for crop diseases of crops virus diseases, verticillium wilts and the like.

The invention discloses a method for preventing and treating tomato yellow leaf curl virus diseases. The method includes cultivating tomatoes in sunlight greenhouses in large rows and small rows; transplanting abutilon theophrasti 15-20 days before the tomatoes are planted in fields; planting one row of abutilon theophrasti at the planting distances of 20cm along the inner side of the root of a north wall of each greenhouse; planting a row of abutilon theophrasti at the planting distances of 2.0m between each two adjacent small field planting rows; pulling out the abutilon theophrasti among the small field planting rows after fruits of fifth panicles of the tomatoes are set. The row spacing of the large rows of the tomatoes planted in the sunlight greenhouses is 80cm, and the row spacing of the small rows of the tomatoes planted in the sunlight greenhouses is 60cm. The leaf age of the abutilon theophrasti is 4 leaves and 1 core when the abutilon theophrasti is transplanted. The method has the advantages that the incidence of the tomato yellow leaf virus diseases can be effectively reduced, and the incidence of tomato yellow leaf virus disease infected tomato varieties can be within the range of 10% under the control generally.

Described herein are chimeric influenza virus gene segments and nucleic acid sequences encoding such chimeric influenza virus gene segments. A chimeric influenza virus gene segment described herein comprises packaging signals found in the non-coding and coding regions of one type of influenza virus gene segment and an open reading frame of a different type of influenza virus gene segment or fragment thereof. Also described herein are recombinant influenza viruses comprising two or more chimeric influenza virus gene segments and the use of such viruses in the prevention and/or treatment of influenza virus disease.

The invention provides a aquaculture system which uses light energy to realize cycle of water with a media of micro-algae and inhibits the disease occurrence of aquaculture species. The system includes two aquaculture subsystems which are connected through pipes for water cycle of aquaculture. The water-recycled aquaculture system based on micro-algae forms biological cycle chain through reasonable combination of the two aquaculture subsystems to significantly improve the efficiency of aquaculture. The circulating water based on micro-algae transfers surplus nutrient in aquaculture of the first aquatic product to the second aquatic product, and to be used as bait of the second aquatic product. Therefore, the water consumption is reduced and the discharged 'waste' is changed to effective nutrient. The bacteriosis occurrence of aquatic products is inhibited by using natural antibiotics secreted by micro-algae, and in addition, the infection probability of virus diseased is reduced.

The invention is a virus removal and rapid propagation technology of sweet potato variety 'Shangshu 19', comprising the following steps: selecting plants which are robust without diseases and insect pests and have characteristics of the variety from growing plants; clipping stem with stem tip; removing visible leaves; sterilizing; peeling the stem tip with 1-2 leaf primodia via a dissecting needle; quickly inoculating into a differentiation and induction culture medium; trimming the sterilized seedling into stem segments with 1-2 internode(s) and switching into an enrichment medium after virus detection; selecting sterilized seedling in vigorous growth to cut into small segments with 1-2 internode(s) and switch into a rooting medium; carrying out domestication on seedling after rooting. The invention has stem tip in virus removal and stem segment in rapid propagation, solves the problems of severe virus disease for sweet potato, poor quality of new cultured breed, germplasm degradation, low yield and the like propagated by using sweet potato block and stem. The invention can artificially control the growing conditions, can not be influenced by nature, and has the advantages of small amount of material use, economical culturing materials, short growth cycle, large propagation coefficient and convenient management and is favor of industrial production.

The invention discloses a green biological water-flush fertilizer, relating to fertilizers. A manufacturing method is as follows: a, adding animal protein powder, vegetable protein powder, complex bacteria and complex enzyme into an amino acid solution, mixing uniformly, placing the mixture under the temperature of 15-35 DEG C, and after 6-8 days, forming a product A; and b, adding a complex nutrition conditioner, a continuous cropping modifier, a biological insect repellant, a harm removing agent, trace elements, a nitrogen-phosphorus-potassium compound fertilizer into the product A, mixing uniformly and obtaining the green biological water-flush fertilizer. The green biological water-flush fertilizer has the beneficial effects that 1, the sprouting rate can be improved, the fast rootingcan be realized, the sufficient nutrition of plants can be ensured, and premature senility resistance and aging resistance are achieved; 2, the yield and the quality of vegetables, melons and fruits are improved; 3, the utilization ratio, the long-term property, fast effect, long effect and stable efficiency of a base fertilizer are improved; 4, the extremely-good inhibiting effect and improving function are achieved for yellow seedlings, runt seedlings, lobules, leaf roll, blight, pythium debaryanum, droop, dead seedling, rot roots, abnormal rotting disease, virus disease, seedling falling disease and the like; and 5, green and unpolluted foods are beneficial to being produced.

The invention relates to a ferulic acid shown in a general formula (I) and the application of derivatives thereof to pesticides. When used as novel anti-phytoviral agents, the derivatives can well inhibit tobacco mosaic viruses, pepper viruses, tomato viruses, sweet potato viruses, potato viruses, melon viruses, maize dwarf mosaic viruses and the like, and effectively prevent and control the virus diseases of various crops such as tobacco, peppers, tomatoes, melons, grains, vegetables, beans and the like, and are particularly suitable for preventing and controlling tobacco mosaic. Meanings of each group are shown in specifications.

The invention provides o-formammidotiazol-benzamide derivatives, and a preparation method and applications thereof. The o-formammidotiazol-benzamide derivatives have the chemical structure general formula represented by the formula I or the formula II. The invention discloses the structure general formula of the compounds, the synthesis method and the applications of the compounds as insecticides, acaricides and bactericides; the compounds are mixed with agriculturally acceptable auxiliary agents or synergistic agents for use in processing crafts of preparing the insecticides, the acaricides and the bactericides. The invention also discloses the applications of the compounds in combination with the commercial insecticides, the acaricides, the bactericides, anti-plant virus agents and plant activators for prevention and treatment of agriculture, forestry, horticulture plant diseases, insect attacks, acarus attacks and virus diseases, and the preparation method of the compounds.

The invention provides a pesticide composition, and in particular relates to an active pesticide composition, compounding one or more of toxic fluoride phosphate, the weight ratio of toxic fluoride phosphate to other active substances is 30:0.15 to 3.3:30, and the content of effective components by weight is 1%-90%. The compound composition can be processed into water dispersible powder, suspending agent, microemulsion, aqueous emulsion, water dispersible granule, dry suspension emulsion and seed coating agent and the like, after accessory ingredient or carrying agent is added. The composition can be used to prevent and treat virus diseases caused by rice stripe virus, rice dwarf virus, maze rough dwarf virus, rice black-streaked dwarf virus, tomato virus, cucumber mosaic virus and tobacco mosaic virus, and has the beneficial effects of enhanced effect, concurrent treatment, postponed pesticide resistance, decreased dosage of toxic fluoride phosphate and reduced cost.

Provided herein are polypeptides comprising portions of the influenza virus hemagglutinin, compositions comprising such polypeptides that can be used as immunogens in vaccines and methods of their use to generate an immune response against multiple influenza subtypes in a subject.

The invention provides lignin derivatives as well as a preparation method and use thereof. The invention relates to compounds containing lignin, and the compounds have a chemical structure general formula represented by a formula I. The invention discloses a structural general formula and a synthetic method of the compounds, application of the compounds used as an antiviral agent and a bactericide, and a processing technology for preparing the antiviral agent and the bactericide by mixing the compounds with agriculturally acceptable auxiliaries or synergists. The invention further discloses application of the compounds in preventing and treating diseases, insect attack, mite attack and virus diseases in agriculture, forestry and horticulture in combination with an insecticide, a miticide, a bactericide, acetylglucosyl bromide and a plant activator and preparation methods of the compounds. The invention further discloses antineoplastic activity of the compounds and application thereof in treating tumors.

The invention provides a formulation composite comprising toxic fluoride phosphate and at least one growth regulator. According to the weight part, the toxic fluoride phosphate accounts for 10%-80% of the formulation composite, the growth regulator accounts for 0.0001%-2% of the formulation composite, the formulation composite also comprises an assistant, an surface active agent, a solvent and a carrier accepted by agriculture, and the formulation composite can be prepared into wettable powder, suspending agent, missible oil, microemulsion, emulsion in water, water dispersible granule, dry suspending agent, seed coating agent and other agents. The formulation composite can be used for preventing and curing tobacco mosaic virus, cucumber mosaic virus, and various virus diseases caused by viruses on rice, such as tobacco mosaic, cucumber mosaic, tomato virus disease, pepper virus disease, rice virus disease and the like and achieves the effects of improving efficacy, treating in a compatible manner, delaying medicine resistance, reducing the using amount of toxic fluoride phosphate and the like.

The invention provides a novel coronavirus antigen epitope and application thereof. A super computer is used for simulating S, E, M and N protein structures of the novel coronavirus, and novel coronavirus epitopes SEQ ID NO 1-38 are obtained through calculation. The epitopes have very good immunogenicity; an antibody generated by inducing a part of epitope polypeptide has the effect of neutralizing the novel coronavirus; the antigen epitope can be combined with antibodies in serum of novel coronavirus patients at home and abroad, has the potential of resisting various novel coronavirus strains, and also has the potential of identifying and applying different strains. The epitope provided by the invention can be used for (1) research and development of novel coronavirus vaccines and universal coronavirus vaccines such as MERS viruses and SARS viruses; and (2) preparing a novel coronavirus antibody, and further detecting and typing viruses and treating diseases caused by the viruses. Thenovel coronavirus antigen epitope has a wide application prospect in the aspects of prevention of coronavirus and propagation and outbreak thereof, and detection and diagnosis of virus strains.

The invention belongs to the technical field of biology, and particularly relates to a fusion protein of SARS-CoV-2, and a vaccine composition of the fusion protein. The fusion protein and the prepared vaccine composition containing the fusion protein overcome the defects of poor immunogenicity and the like of subunit vaccines, can induce the specific immune response aiming at SARS-CoV-2, and achieve the purposes of inhibiting the replication of SARS-CoV-2, inhibiting the spread of SARS-CoV-2 or preventing the settlement of SARS-CoV-2 common strains and variant strains in SARS-CoV-2 host bodies. The fusion protein and the vaccine composition containing the fusion protein can effectively prevent and/or treat novel coronavirus pneumonia (Corona Virus Disease 2019, COVID-19). The fusion protein can be recombined and expressed in large quantities by the aid of the genetic engineering technology, the consumed time is short, and the large-scale production can be facilitated.

The invention provides 1,2,3-thiadiazole-1,3,4-thiadiazole derivatives, and a preparation method and application thereof. The invention relates to 1,2,3-thiadiazole-containing heterocyclic compounds with the chemical structural general formula shown as the specification. The invention discloses the structural general formula of the compounds, a synthesizing method of the compounds, application ofthe compounds serving as pesticides, bactericides, anti-plant-virus agents and plant activating agents, and a process for preparing the pesticides, the bactericides, the anti-plant-virus agents and the plant activating agents by mixing the compounds and agriculturally acceptable adjuvants or synergists. The invention also discloses application of the compounds when the compounds are combined withcommodities of the pesticides, the bactericides, the anti-plant-virus agents and the plant activating agents in prevention and control of agricultural, forestry, horticultural and health diseases, insect pests and virus diseases, and a preparation method of the compounds.

The invention relates to a bactericidal composition containing prothioconazole, which contains active ingredient A and active ingredient B, wherein active ingredient A is selected from prothioconazole, and active ingredient B is selected from thiophanate-methyl, multibacterium One of Ling and prochloraz, wherein the weight ratio of active ingredient A to active ingredient B is 1:80 to 80:1, made into wettable powder, water dispersible granule, suspending agent, suspoemulsion, water emulsion, Microemulsion, used to control powdery mildew, sheath blight, fusarium wilt, leaf spot, rust, sclerotinia, viral disease, anthracnose, gray mold, ring spot, bakanae disease, rice blast, early blight, Diseases such as green mold, pedicle rot, penicillium, flax spot, scab, blight, etc. have the characteristics of small dosage, resistance to rain erosion, and obvious synergistic effects.

The invention provides a high-efficiency, rapid and safe compound pharmaceutical composition for curing virus diseases of animals and a preparation method thereof. The compound pharmaceutical composition comprises the following components of forsythia fruit, isatis root, bamboo leaf, scutellaria root, honeysuckle flower, isatis leaf, milkvetch root, longspur epimedium, glossy privet fruit, dried rehmannia root, red sage root, chuanxiong rhizome, dark plum, peppergrass, tendril-leaved fritillary bulb, tangerine peel, lilyturf root, liquorice and florfenicol. The pharmaceutical composition has the function of superactive antivirus, has strong antivirus and antibiosis actions, remarkable therapeutic effect, fast effect, complete treatment and no relapse, is not easy to generate drug resistance and can be effectively used for preventing and curing the virus diseases of animals. The compound pharmaceutical composition can be powder preparation formulation. The invention also provides feed containing the compound pharmaceutical composition.