282 results about "Vaccination" patented technology

The invention discloses an application of kaempferol in preparation of a medicine for treating or preventing PEDV (Porcine Epidemic Diarrhea Virus) infection. The kaempferol can obviously inhibit the replication of the PEDV in Vero and LLC-PK1 cells through 3C-like protease targeting the PEDV, so that the kaempferol can be used for preparing the medicine for preventing and treating the PEDV. Besides, kaempferol, as a natural substance separated from mulberries, can be used as a feed additive for a long time so as to achieve the purpose of preventing epidemic diseases, and does not cause generation of drug-resistant strains and other toxic and side effects after being used for a long time; the defects of immune failure possibly caused by vaccination, virus variation caused by use of antiviral drugs and the like are overcome.

The invention discloses an antigen fusion protein and application thereof in preparation of a live vaccine for preventing infectious bursal disease. Specifically disclosed are antigen fusion proteins comprising a VP2 protein, a trimer tag, and a C3d protein. The invention also discloses recombinant Eimeria heap constructed by using the antigen fusion protein and application of the recombinant Eimeria heap in preparation of IBDV live vaccines. The oocyst of the recombinant Eimeria heap can effectively induce humoral immune response aiming at IBDV as a vaccine active ingredient, the level of an induced antibody is obviously higher than that of an insect strain expressed by a single VP2 antigen, viruses can be more effectively neutralized, the immune protection efficacy is improved, the safety is high, and the oocyst has the potential of serving as a live vector genetic engineering vaccine. The IBDV live vaccine can be orally taken through drinking water or feed, vaccination is simple, large-scale immunization of chicken flocks can be achieved, and the IBDV live vaccine is economical and efficient and has a wide prospect of being applied to prevention and control of the IBDV of the chicken flocks.

The utility model belongs to the technical field of breeding fences, and provides a channel type plateau grazing yak epidemic prevention sampling mating fence which comprises a fence body, a first connecting rod and a second connecting rod. A plurality of first supporting rods and second supporting rods are fixedly connected to the bottom surfaces of the two sets of top rods, a plurality of connecting rods are installed between the two sets of top rods in an array mode, cells are formed between the first supporting rods and the second supporting rods, and surrounding rods are installed in the cells in an array mode; the first door body is fixed at the inlet end of the fence body; the second door body is fixed at the outlet end of the fence body; by arranging the fence body, the first door body and the second door body, the operation efficiency of vaccination, sampling and hybridization is greatly improved, and the current situation that an existing fence is small in yak processing number and low in efficiency is changed.

The utility model discloses a poultry vaccination marking mechanism which comprises an ink jet mechanism, the ink jet mechanism is flat and hollow and is connected with an external liquid pump through a hose, one side of the ink jet mechanism is provided with a nozzle, the other side of the ink jet mechanism is rotatably provided with a limiting ball, one end of the limiting ball is connected with a connecting mechanism through a connecting rod, and the other end of the limiting ball is connected with the connecting mechanism. The input end of the liquid pump is connected with an ink box containing marking ink through a pipeline, and the output end of the liquid pump is connected with the ink jetting mechanism through a hose. The trigger switch of the liquid pump can be linked with the vaccine injector, when the vaccine injector is started to inject vaccines once, the liquid pump operates once, a certain amount of ink is sprayed to feathers on poultry bodies, and the ink-jet mechanism is linked with the vaccine injection mechanism to inject the vaccines into the feathers. Meanwhile, the poultry feather marking device is small and exquisite in design, light, simple in structure, low in use and maintenance cost and suitable for small-scale poultry breeding.

The utility model belongs to the technical field of Tibetan pig disease prevention and treatment, particularly relates to a vaccine injector for Tibetan pig disease prevention and treatment, and aims to solve the problems that when vaccine injection is carried out on Tibetan pigs in the same batch of growth stage, workers often hold injectors with hands to go to pigsties to inject the Tibetan pigs one by one, piglets missing vaccine injection are prone to occurring, and potential risks exist. According to the scheme, the device comprises an electric conveying belt, the electric conveying belt is arranged on a channel between two adjacent pigsties, and two guardrails for preventing piglets from falling off are symmetrically arranged above the electric conveying belt. When the piglet vaccine injection device is used, through the design of the electric conveying belt and the guardrails, a worker can conveniently inject vaccines to piglets one by one, and therefore the situation that the piglets are missed to be vaccinated is avoided; through the design of the adjusting assembly, the distance between the guardrails can be adjusted according to the body types of piglets of different growth batches; through the design of the needle-free injection assembly, stress reaction and cross infection risks caused by traditional needle puncture are avoided.

The present invention relates to a composition comprising physiological dendritic cells and at least one mRNA. The invention further relates to a composition comprising physiological dendritic cells and at least one mRNA for vaccination.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

1. The name of the design product: pre-filled syringe (integrated safety type). 2. The use of the design product: injection tools for medical institutions, home care, and vaccination fields. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an information digital integration system of an edge intelligent mobile hospital, and relates to the technical field of mobile application development. Patient nursing record quantity, vaccination quantity, sickbed use quantity, patient medical record quantity needing to be checked, patient quantity needing to be checked, prescription issuing quantity, stock quantity corresponding to various medicines, use quantity corresponding to various medicines and purchase quantity of various medicines corresponding to an intelligent mobile hospital at a specified edge in a specified area are analyzed; according to the method and the system, the workload evaluation coefficient of nurses, the workload evaluation coefficient of doctors and the drug use evaluation coefficient of each drug in the intelligent mobile hospital at the specified edge of the specified region are calculated, so that the workload of medical staff and the use condition of the drugs can be evaluated more accurately; the mobile hospital can control the cost more accurately, resource waste is avoided, and reasonable control over the cost is achieved.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The invention discloses a multi-modal data-based vaccination behavior correction method, system and device, and relates to the technical field of vaccination behavior correction, the method comprises the following steps: constructing a multi-modal data sensing module; establishing a multi-modal data processing channel, and collecting inoculation video data, inoculation injection data and inoculation physiological signal data; performing feature extraction to obtain an inoculation visual feature set, an inoculation injection feature set and an inoculation physiological feature set; performing decision level fusion to generate an inoculation behavior feature set; and carrying out abnormity identification and correction prompting on the inoculation behavior feature set, determining inoculation behavior correction information, and carrying out vaccination correction and inoculation whole process recording. The technical problems that in the prior art, no means for standard correction and whole-process recording of vaccination behaviors exist, and vaccination accuracy and safety are difficult to guarantee are solved, and the technical effects that intelligent correction and whole-process recording of the vaccination behaviors are achieved, and vaccination standardization and safety are improved are achieved.

Provided are methods for inducing immune responses against pathogens in a mammal. The methods comprise administering a single cycle adenovirus (SC-Ad) comprising a nucleic acid sequence encoding an immunogen of said pathogen to said mammal. The SC-Ad is administered by inhalation and infects a cell of said mammal, thereby causing expression of said immunogen leading to the induction of said immune response. New infectious virions are not produced. The methods may be of particular utility in vaccination for respiratory pathogens. Corresponding medical uses of the SC-Ads are also provided.

Method for the installation of a spraying device (10) for spraying a fluid (F), in particular a liquid vaccine solution, towards boxes (20) being conveyed past the spraying device, the boxes preferably containing animals, in particular chickens or chicks, to be vaccinated by spray vaccination, the method comprising: - receiving sensor signals (SS) in a sensor device (21) for detecting boxes (20) being conveyed past the spraying device (1), - receiving box size data (BS), the box size data representing a size of the boxes (20), - automatically determining, based on the box size data and the sensor signals (SS), the speed (S) of the boxes being conveyed past the spraying device (1), and - automatically determining a type (T) and / or number of nozzles (6) to be used for spraying the fluid and / or an, in particular vertical, nozzle position (P) to be set.

In one aspect, an EID button tag is provided herein for tagging and identifying cattle as being inoculated against brucellosis, the EID button tag including: a shell having a central opening; a transponder located in the shell; a male punch having a disc-shaped punch body and a stem extending distally therefrom, the stem having a head configured for irreversible insertion into the central opening, wherein a mounting opening is formed through the punch body with a mounting channel extending distally from the mounting opening and coaxially along the stem; and, a vaccination identification button having a disc-shaped visual identification body and a mounting stem extending distally therefrom, wherein the mounting stem is configured for irreversible insertion into the mounting channel. The punch body and the visual identification body are primarily tinted with different colors to provide visual identification of a head of cattle being inoculated against brucellosis.

1. Name of the product in this design: Animal vaccination station (for veterinary use). 2. Purpose of this design: For vaccinating animals. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the field of aquaculture, in particular to a preparation method and application of a recombinant live vector vaccine for infectious hematopoietic necrosis of fish. In order to solve the problem of prevention and control of the infectious hematopoietic necrosis of the fish in the aquatic product industry, a replication-defective adenovirus type 5 is selected as a target gene expression vector to construct a recombinant adenovirus vector comprising a glycoprotein gene and a nucleoprotein gene of the infectious hematopoietic necrosis virus of the fish, and a recombinant virus is obtained; the safe and effective recombinant live vector vaccine for the infectious hematopoietic necrosis of the fish is created. According to the vaccine, immunization is carried out on fishes in a soaking or bait feeding mode, the total CPM of the fishes immunized by the vaccine is 6.67%, and the total CPM of the fishes in a non-immunized control group is 94.00%. In addition, the RPS of the vaccination group fish and the RPS of the empty vector control group fish are 92.90% and 9.22% respectively. The method is at a leading level in the field of fish biological medicines at present and has remarkable creativity.

1. The name of the design product: integrated AI intelligent vaccination chair. 2. The use of the design product: for vaccination chair. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: front view.

1. The name of the design product: multifunctional vaccination platform. 2. The use of the design product: intelligent vaccination equipment integrating information registration, vaccine use management, and vaccination. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention relates to the use of mesenchymal stem cells (MSCs) for enhancing the immune response of elderly or animal subjects to vaccination. According to the application, the defects of spleen stromal cell networks and lymphocyte structures of old subjects can be repaired by applying the MSC in advance, and the immune level of organisms is improved; and the vaccine is injected after a period of time, so that the specific antibody level after vaccine immunization can be improved. The effect can also significantly prevent the elderly subjects from being infected by influenza. Therefore, the MSC has a good application prospect in solving related immune decline of old people.

The present invention relates to vaccine compositions, most notably vaccine compositions wherein the antigenic component is large, for example over 50 kDa, or multimeric, i.e. comprised of subunits. Such antigenic components are of particular interest, because they may represent antigenic components from pathogens that currently it is not possible to vaccinate against. The invention relates to a composition comprising a particle displaying an antigenic component, wherein said composition comprises an antigenic component comprising a first peptide tag, and a moiety comprising a second peptide tag, wherein the antigenic component and the moiety are linked via an isopeptide bond between said first and second peptide tags, and wherein the antigenic component is over 50 kDa, or alternatively is multimeric.

The invention discloses a lipid compound for delivering a therapeutic agent as well as a preparation method and application thereof. The invention relates to a lipid compound, which is a compound with a structural formula I or a pharmaceutically acceptable form thereof. The lipid compounds may be used in combination with other lipid components, such as neutral lipids, cholesterol, and polymer-bound lipids, to form lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes (e.g., vaccination), enriching the species of ionizable lipid compounds.

1. Name of the product in this design: Neonatal Inoculation Table. 2. Purpose of this design: This design is intended for use in administering vaccines to newborns. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention relates to lipid nanoparticle compositions. Provided herein are lipids that can be used in combination with other lipid components, such as neutral lipids, cholesterol, and polymer-conjugated lipids, to form lipid nanoparticles for the delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination.

The new alpharetrovirus-based particles are suitable for high efficiency of transiently transducing animal cells. e.g. human or murine cells, and which efficiently introduce coding and non-coding RNA contained in the alpharetrovirus-based particles into target cells The alpharetrovirus-based particles also provide for high efficiency of the activity and / or integrity of the RNA that is introduced into the animal cells, as the particles protect the incoming RNA from degradation during entry. The transferred RNA can be of non-coding nature (e.g. single guide (sg) RNA. short-hairpin (sh) RNA. micro RNA. or long non-coding (Inc) RNA. or the RNA may encode proteins or peptides. e.g. receptors. transcription factors. cellular enzymes, antigens for use in vaccination, gene / protein therapy and / or gene editing nucleases, recombinases and transposases.

A point of care immunization system based upon a range of detection methods to rapidly test a patient in order to ascertain an immunization profile so that vaccinations can be administered to address identified gaps. A point of care system comprised of sample and test strips / cartridges, with said test strips / cartridges configured to meet healthcare requirements of national governing bodies. A point of care system is provided that can function as a stand-alone diagnostic system, a stand-alone kit or with a device.

To provide a method for using Antrodia cinnamomea essential oil for anesthetic treatment of spotted seabass, in which a problem to be solved is the feasibility of using Antrodia cinnamomea essential oil, which is a natural plant extract, as a new anesthetic to anesthetize live fish, and reduction in stress reaction and tissue damage in the process of anesthetizing live fish.SOLUTION: After spotted seabass is anesthetized by adding Antrodia cinnamomea essential oil in water, the morphological structure of the gill tissue of the spotted seabass and the influence on physiological, biochemical, and oxidative stress are studied, and the blood biochemical stress level, antioxidant enzyme activities, and immune indexes of the spotted seabass are measured to provide a theoretical basis for the anesthetic treatment of the sea fish. As compared with the expensive MS-222 and linalool, the price of Antrodia cinnamomea essential oil is 1 / 10 thereof, which can effectively reduce the cost of anesthesia, is particularly suitable for vaccination, blood collection, weighing, and transportation of live fish, etc., and has a higher economic benefit.SELECTED DRAWING: Figure 2

Provided are methods of biasing a response of a vaccine recipient's immune system toward protective sensitization. Methods include administering an agent or substance to the site of a subject of a temporally interacting cell-mediated allergic reaction to enhance the resulting level of protective sensitization.

Provided are compositions and methods for reducing pre-existing antibodies against viral vector or gene-editing related proteins. The compositions showed reduction in various antibody titers by administration of a liposome composition complexed with a protein or fragment thereof of a viral vector. The liposomes comprise phosphatidylcholine and phosphatidylserine, wherein some or all of the PS is present as lyso-PS. The compositions and methods can be used in conjunction with gene therapy and nucleic acid based vector based vaccinations and therapeutics.