512 results about "Vaccination" patented technology

The invention discloses an application of phloretin in preparation of a medicine or a feed additive for treating or preventing swine envelope virus infection, the medicine is phloretin or oral liquid, granules, tablets and powder prepared from phloretin as an effective component and a solvent or an auxiliary material, and the use dosage is 2.5-10mg / kg of the body weight of a pig; or the phloretin is directly added into the feed, and the addition amount of the phloretin is 0.01-0.03% of the total weight of the pig feed. The phloretin or the composition containing the phloretin is used as a medicine or a feed additive, is high in safety and free of toxic and side effects, and has the effects of remarkably inhibiting replication of envelope viruses such as porcine epidemic diarrhea virus, porcine reproductive and respiratory syndrome virus and African swine fever virus and reducing the toxicity of the porcine envelope viruses; the defects of immune failure possibly caused by vaccination, virus variation caused by use of antiviral drugs and the like are overcome, the morbidity and mortality of the piglets infected with the swine envelope virus are effectively reduced, and the effect of preventing and treating or preventing the swine envelope virus infection diseases is achieved.

The present invention relates to methods for predicting whether peptides or polypeptides comprising disease specific amino acid modifications, in particular tumor-associated neo-antigens, comprise epitopes, in particular tumor-associated neo-epitopes, which are useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.

A system for AI-driven predictive healthcare for pandemic prevention, which includes the following: a data collection module configured to capture health-related data from IoT-based wearable devices, electronic health records (EHRs), environmental sensors, and social media in real time; an AI-driven analysis module that is operationally linked to the data collection module and configured to use deep learning and natural language processing (NLP) techniques to process and analyze collected data in order to detect potential disease outbreaks; a predictive modeling module configured to use hybrid epidemiological and AI models to predict disease transmission patterns based on mobility data, population density, and historical infection trends; a warning and response module that automatically generates and disseminates notifications to health authorities, medical professionals, and vulnerable individuals based on predicted outbreak risks; a blockchain-based data security module configured to ensure the secure storage, access control, and verification of health-related data through decentralized ledger technology and smart contracts; and a decision support module that is operationally linked to the predictive modeling module and provides AI-driven recommendations for healthcare resource allocation, vaccination strategies, quarantine measures and public health measures.

Drug delivery nanoparticle compositions and methods for the treatment of a cancer are provided that can be used individually or in combination. These compositions and methods include: (1) exogenous vaccination using neoantigens or tumor-associated antigens to potentiate an anti-tumor immune response; (2) nanoparticle-based drug delivery targeting the liver, aimed at reprogramming the hepatic immune environment to reduce or eliminate tumor antigen tolerance, thereby enhancing the immune system's ability to combat metastatic cancer; and (3) expansion of the liver metastasis treatment platform to target tumor-associated lymphoid structures, supporting the immune response at the primary tumor site. Any of these methods may be optionally combined with chemo-immunotherapy for enhanced efficacy.

The invention relates to the field of aquaculture, in particular to a preparation method and application of a larimichthys crocea iridovirus recombinant live vector vaccine. According to the invention, replication-deficient type 5 adenovirus is selected as a target gene expression vector, a recombinant adenovirus vector comprising main capsid protein of iridovirus is constructed, recombinant virus is obtained, and the safe and effective large yellow croaker iridovirus disease recombinant live vector vaccine is created. According to the vaccine, the larimichthys crocea is immunized in a soaking or bait feeding mode, the CPM of the larimichthys crocea immunized by the vaccine is 12.0%, and the CPM of the fish without being immunized by the vaccine is 62.0%. In addition, the RPS of the inoculated fish and the RPS of the empty carrier control group fish are 80.65% and 9.68% respectively. The method is at a leading level in the field of pseudosciaena crocea biomedicine at present, and creativity is remarkable.

The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

The invention discloses an application of kaempferol in preparation of a medicine for treating or preventing PEDV (Porcine Epidemic Diarrhea Virus) infection. The kaempferol can obviously inhibit the replication of the PEDV in Vero and LLC-PK1 cells through 3C-like protease targeting the PEDV, so that the kaempferol can be used for preparing the medicine for preventing and treating the PEDV. Besides, kaempferol, as a natural substance separated from mulberries, can be used as a feed additive for a long time so as to achieve the purpose of preventing epidemic diseases, and does not cause generation of drug-resistant strains and other toxic and side effects after being used for a long time; the defects of immune failure possibly caused by vaccination, virus variation caused by use of antiviral drugs and the like are overcome.

The invention discloses an antigen fusion protein and application thereof in preparation of a live vaccine for preventing infectious bursal disease. Specifically disclosed are antigen fusion proteins comprising a VP2 protein, a trimer tag, and a C3d protein. The invention also discloses recombinant Eimeria heap constructed by using the antigen fusion protein and application of the recombinant Eimeria heap in preparation of IBDV live vaccines. The oocyst of the recombinant Eimeria heap can effectively induce humoral immune response aiming at IBDV as a vaccine active ingredient, the level of an induced antibody is obviously higher than that of an insect strain expressed by a single VP2 antigen, viruses can be more effectively neutralized, the immune protection efficacy is improved, the safety is high, and the oocyst has the potential of serving as a live vector genetic engineering vaccine. The IBDV live vaccine can be orally taken through drinking water or feed, vaccination is simple, large-scale immunization of chicken flocks can be achieved, and the IBDV live vaccine is economical and efficient and has a wide prospect of being applied to prevention and control of the IBDV of the chicken flocks.

The utility model discloses an inoculation table capable of alternately receiving medicines, belongs to the technical field of vaccine distribution automation, and solves the problem of low seedling emergence efficiency of the inoculation table capable of alternately receiving medicines in the prior art. The inoculation table capable of alternately receiving the medicines comprises an electric drawer, a vaccine guide device, a guide switching device, an AGV (Automatic Guided Vehicle) distribution vehicle and a vaccine pouring device, the at least two electric drawers are vertically arranged, the guide switching device can adjust the position of the vaccine guide device so that vaccines can alternately enter the two electric drawers, and the AGV distribution vehicle is used for providing power for movement of the guide switching device and the vaccine pouring device. According to the vaccination table capable of alternately receiving the medicines, vaccines can be alternately put into the two electric drawers through the arrangement of the AGV distribution vehicle, the vaccine pouring device, the guide switching device and the vaccine guide device, and the electric drawers are vertically arranged; two drawers for alternately receiving vaccines can be vertically arranged on one inoculation station, and the comfort level of medical staff is not affected.

The invention is based on the deletion of 21 amino acids from the C-terminal region of the S2 subunit of SARS-CoV2-S protein and transporting the Si subunit, which is fused to S2 to the cell membranes. In this way, the presentation of the antigenic S1 subunit of SARS-CoV2-S protein in large amounts and in its natural structure in the cell membrane and its use as a whole cell or cell membrane has been determined as a new vaccination protocol for the SARS-CoV-2. Designing the S2 subunit of SARS-CoV2-S protein as a carrier, fusing any bacterial, viral, and tumor proteins with antigenic properties and transporting it to the cell membrane will be a comprehensive vaccination protocol that will cover all bacteria, viruses and even tumors.

This disclosure provides, in some aspects, multi-component trans-amplifying RNA (taRNA) vaccines that comprise a first nanoparticle (R-NP) comprising a polynucleotide encoding a replicase and a second nanoparticle (Tr-NP) comprising a polynucleotide comprising a nucleic acid encoding a payload (e.g., antigen), operably linked to a conserved sequence element (CSE) that is cognate to the replicase; methods of production thereof; and methods of use thereof.

The utility model belongs to the technical field of breeding fences, and provides a channel type plateau grazing yak epidemic prevention sampling mating fence which comprises a fence body, a first connecting rod and a second connecting rod. A plurality of first supporting rods and second supporting rods are fixedly connected to the bottom surfaces of the two sets of top rods, a plurality of connecting rods are installed between the two sets of top rods in an array mode, cells are formed between the first supporting rods and the second supporting rods, and surrounding rods are installed in the cells in an array mode; the first door body is fixed at the inlet end of the fence body; the second door body is fixed at the outlet end of the fence body; by arranging the fence body, the first door body and the second door body, the operation efficiency of vaccination, sampling and hybridization is greatly improved, and the current situation that an existing fence is small in yak processing number and low in efficiency is changed.

The invention provides an animal vaccination risk prediction method and system based on a cross-modal large model, and relates to the technical field of vaccination risk prediction. Comprising a multi-modal data acquisition and integration module, a cross-modal feature extraction and semantic alignment module, a pre-training model construction and transfer learning module, a risk prediction and decision support module and a model verification and iterative optimization module. Misjudgment caused by same surface symptoms can be effectively avoided, in animal epidemic disease diagnosis, similar symptoms may be caused by different viruses, a traditional method is easily interfered by surface phenomena, and the optimized method can be used for diagnosis of animal epidemic diseases by constructing a causal diagram, analyzing real causes of symptoms and stripping confounding factors such as environment and physiological status. Through the means, the model can more accurately distinguish virus types, the misjudgment risk is remarkably reduced, and a reliable basis is provided for a subsequent vaccination strategy.

The present invention relates to vaccine compositions, most particularly vaccine compositions wherein the antigenic component is large (e.g. greater than 50 kDa), or is multimeric (i.e. composed of subunits). Such antigenic components are of particular interest as they may represent antigenic components from pathogens against which vaccines are currently not available. The present invention relates to a composition comprising particles displaying an antigenic component, wherein the composition comprises an antigenic component comprising a first peptide tag and a portion comprising a second peptide tag, wherein the antigenic component and the portion are linked by an isopeptide bond between the first and second peptide tags, and wherein the antigenic component is greater than 50 kDa, or alternatively is multimeric.

The utility model discloses a poultry vaccination marking mechanism which comprises an ink jet mechanism, the ink jet mechanism is flat and hollow and is connected with an external liquid pump through a hose, one side of the ink jet mechanism is provided with a nozzle, the other side of the ink jet mechanism is rotatably provided with a limiting ball, one end of the limiting ball is connected with a connecting mechanism through a connecting rod, and the other end of the limiting ball is connected with the connecting mechanism. The input end of the liquid pump is connected with an ink box containing marking ink through a pipeline, and the output end of the liquid pump is connected with the ink jetting mechanism through a hose. The trigger switch of the liquid pump can be linked with the vaccine injector, when the vaccine injector is started to inject vaccines once, the liquid pump operates once, a certain amount of ink is sprayed to feathers on poultry bodies, and the ink-jet mechanism is linked with the vaccine injection mechanism to inject the vaccines into the feathers. Meanwhile, the poultry feather marking device is small and exquisite in design, light, simple in structure, low in use and maintenance cost and suitable for small-scale poultry breeding.

The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

The invention discloses a population antibody concentration dynamic evaluation method based on neural network simulation calculation. The method comprises the following steps: S1, acquiring a multi-modal immunology related data set; s2, generating a complete multi-modal feature data set; s3, constructing a deep learning model based on the multi-modal feature data set; s4, training the segmented neural network model; s5, inputting the multi-modal immunology related data of the to-be-evaluated crowd into the trained sectional neural network model, and generating a prediction result of the individual antibody concentration changing along with time; s6, summarizing prediction data of a plurality of individuals according to the prediction result of the individual antibody concentration changing along with time, and establishing a population overall antibody concentration dynamic distribution model; and S7, providing vaccination optimization strategy suggestions and crowd immune intervention schemes in combination with data output. The invention provides key technical support for immune monitoring and vaccination strategy optimization.

The utility model belongs to the technical field of Tibetan pig disease prevention and treatment, particularly relates to a vaccine injector for Tibetan pig disease prevention and treatment, and aims to solve the problems that when vaccine injection is carried out on Tibetan pigs in the same batch of growth stage, workers often hold injectors with hands to go to pigsties to inject the Tibetan pigs one by one, piglets missing vaccine injection are prone to occurring, and potential risks exist. According to the scheme, the device comprises an electric conveying belt, the electric conveying belt is arranged on a channel between two adjacent pigsties, and two guardrails for preventing piglets from falling off are symmetrically arranged above the electric conveying belt. When the piglet vaccine injection device is used, through the design of the electric conveying belt and the guardrails, a worker can conveniently inject vaccines to piglets one by one, and therefore the situation that the piglets are missed to be vaccinated is avoided; through the design of the adjusting assembly, the distance between the guardrails can be adjusted according to the body types of piglets of different growth batches; through the design of the needle-free injection assembly, stress reaction and cross infection risks caused by traditional needle puncture are avoided.

Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and / or concentration of anti-SARS-CoV-2 antibodies in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths. In certain non-limiting embodiments, the kits, microfluidics devices, and methods can distinguish between anti-SARS-CoV-2 antibodies generated in response to vaccination from anti-SARS-CoV-2 antibodies generated in response to infection.

The present invention relates to a composition comprising physiological dendritic cells and at least one mRNA. The invention further relates to a composition comprising physiological dendritic cells and at least one mRNA for vaccination.

This invention presents novel lipid and lipidoid nanoparticle (LNP and LiNP) formulations enhanced with specifically characterized surfactants. These surfactants exhibit unique Langmuir isotherm properties, ensuring optimal stabilization of the nanoparticles. The described formulations improve the stability, reduce aggregation, and mitigate challenges faced during purification, such as filtration clogging or fouling. Integral to the innovation is a method for determining the suitability of surfactants as stabilizers based on predetermined Langmuir isotherm values and filtration speeds. The stabilized nanoparticles, when formulated with therapeutic agents, have demonstrated potential in medical applications, particularly in the realm of mRNA delivery, vaccination and immunization.

A fusion protein, and compositions, kits, granulated antigens, vaccines and pharmaceutical compositions comprising the same. The invention also relates to a fusion protein and a composition comprising the fusion protein, a kit and application of the granulated antigen in preparation of a pharmaceutical composition or a vaccine. The granulated antigens are particularly suitable for vaccine production and vaccination and have advantages in the prevention and / or treatment of viral infections.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

The invention relates to the technical field of biological medicine, and provides a Chinese herbal medicine vesicle-LNP hybrid tumor mRNA vaccine and application thereof. The tumor mRNA vaccine disclosed by the invention is obtained by hybridizing Chinese herbal medicine nano-vesicles and lipid nano-particles loaded with tumor antigen mRNA. According to the invention, the characteristic of good biocompatibility of Chinese herbal medicines is utilized, so that the safety risk of the cationic lipid carrier is reduced. By combining the characteristics of Chinese herbal medicines, the nano-vesicles are extracted, so that the LNP is promoted to more effectively target antigen-presenting cells, the uptake level of the antigen-presenting cells is promoted, the phagocytosis of mRNA is enhanced, and the targeting and transcriptional expression level of mRNA can be enhanced. Finally, the Chinese herbal medicine nano vesicle-LNP hybrid tumor mRNA vaccine can strengthen the curative effects of inhibiting tumor progression, tumor recurrence and tumor metastasis after the tumor mRNA vaccine is inoculated, and a path is opened up for the combination of the tumor mRNA vaccine and richer immunotherapy means.

The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid ether metal chelate, a radiohalogenated phospholipid ether, or other targeted radiotherapy (TRT) agent that is differentially retained within malignant solid tumor tissue, and either (a) performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or (b) performing immunotherapy in the subject by systemically administering to the subject an immunostimulatory agent, such as an immune checkpoint inhibitor. In a non-limiting example, the radioactive phospholipid ether metal chelate or radiohalogenated phospholipid ether has the formula:wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half-life of greater than 6 hours and less than 30 days, or wherein R1 comprises a radioactive halogen isotope. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

1. The name of the design product: pre-filled syringe (integrated safety type). 2. The use of the design product: injection tools for medical institutions, home care, and vaccination fields. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an information digital integration system of an edge intelligent mobile hospital, and relates to the technical field of mobile application development. Patient nursing record quantity, vaccination quantity, sickbed use quantity, patient medical record quantity needing to be checked, patient quantity needing to be checked, prescription issuing quantity, stock quantity corresponding to various medicines, use quantity corresponding to various medicines and purchase quantity of various medicines corresponding to an intelligent mobile hospital at a specified edge in a specified area are analyzed; according to the method and the system, the workload evaluation coefficient of nurses, the workload evaluation coefficient of doctors and the drug use evaluation coefficient of each drug in the intelligent mobile hospital at the specified edge of the specified region are calculated, so that the workload of medical staff and the use condition of the drugs can be evaluated more accurately; the mobile hospital can control the cost more accurately, resource waste is avoided, and reasonable control over the cost is achieved.

The invention discloses a spleen-targeted nano platform construction method suitable for tumor vaccination, and particularly relates to the field of vaccines.The spleen-targeted nano platform construction method comprises the steps that S1, CL15H6-DOPS LNPs, spherical polymer vesicles and erythrocyte membrane coated nano-particles are selected as spleen-targeted nano-carriers; s2, integrating an immunologic adjuvant; mn < 2 + > doped LNPs, ultrasonic response lipidosome and a CD3 antibody are selected to be coupled to serve as an integration material; s3, delivering in vivo; animal models are selected for in-vivo delivery and curative effect verification, and B16F10 melanoma mice, MC38 colon cancer mice and non-human primates are selected as the animal models respectively. By optimizing the chain length and the surface topological structure (such as spherical polymer vesicles) of the liposome, the spleen enrichment rate is remarkably increased, and the red marrow myeloid cell uptake efficiency is enhanced. By combining with common delivery of a manganese adjuvant, an STING channel is activated, secretion of type I interferon is promoted, and the proportion of antigen-specific CD8 + T cells and the tumor inhibition rate are increased.

The present application relates to scaffolds for treating solid tumor cells and evasion variants. Implantable stents are described that treat solid tumors and evasion variants and provide effective vaccination against cancer recurrence. The scaffold includes a genetically reprogrammed lymphocyte and a lymphocyte activating portion.