181 results about "Vaccination" patented technology

The utility model belongs to the technical field of breeding fences, and provides a channel type plateau grazing yak epidemic prevention sampling mating fence which comprises a fence body, a first connecting rod and a second connecting rod. A plurality of first supporting rods and second supporting rods are fixedly connected to the bottom surfaces of the two sets of top rods, a plurality of connecting rods are installed between the two sets of top rods in an array mode, cells are formed between the first supporting rods and the second supporting rods, and surrounding rods are installed in the cells in an array mode; the first door body is fixed at the inlet end of the fence body; the second door body is fixed at the outlet end of the fence body; by arranging the fence body, the first door body and the second door body, the operation efficiency of vaccination, sampling and hybridization is greatly improved, and the current situation that an existing fence is small in yak processing number and low in efficiency is changed.

The utility model discloses a poultry vaccination marking mechanism which comprises an ink jet mechanism, the ink jet mechanism is flat and hollow and is connected with an external liquid pump through a hose, one side of the ink jet mechanism is provided with a nozzle, the other side of the ink jet mechanism is rotatably provided with a limiting ball, one end of the limiting ball is connected with a connecting mechanism through a connecting rod, and the other end of the limiting ball is connected with the connecting mechanism. The input end of the liquid pump is connected with an ink box containing marking ink through a pipeline, and the output end of the liquid pump is connected with the ink jetting mechanism through a hose. The trigger switch of the liquid pump can be linked with the vaccine injector, when the vaccine injector is started to inject vaccines once, the liquid pump operates once, a certain amount of ink is sprayed to feathers on poultry bodies, and the ink-jet mechanism is linked with the vaccine injection mechanism to inject the vaccines into the feathers. Meanwhile, the poultry feather marking device is small and exquisite in design, light, simple in structure, low in use and maintenance cost and suitable for small-scale poultry breeding.

The present invention relates to a composition comprising physiological dendritic cells and at least one mRNA. The invention further relates to a composition comprising physiological dendritic cells and at least one mRNA for vaccination.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

1. The name of the design product: pre-filled syringe (integrated safety type). 2. The use of the design product: injection tools for medical institutions, home care, and vaccination fields. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an information digital integration system of an edge intelligent mobile hospital, and relates to the technical field of mobile application development. Patient nursing record quantity, vaccination quantity, sickbed use quantity, patient medical record quantity needing to be checked, patient quantity needing to be checked, prescription issuing quantity, stock quantity corresponding to various medicines, use quantity corresponding to various medicines and purchase quantity of various medicines corresponding to an intelligent mobile hospital at a specified edge in a specified area are analyzed; according to the method and the system, the workload evaluation coefficient of nurses, the workload evaluation coefficient of doctors and the drug use evaluation coefficient of each drug in the intelligent mobile hospital at the specified edge of the specified region are calculated, so that the workload of medical staff and the use condition of the drugs can be evaluated more accurately; the mobile hospital can control the cost more accurately, resource waste is avoided, and reasonable control over the cost is achieved.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

Method for the installation of a spraying device (10) for spraying a fluid (F), in particular a liquid vaccine solution, towards boxes (20) being conveyed past the spraying device, the boxes preferably containing animals, in particular chickens or chicks, to be vaccinated by spray vaccination, the method comprising: - receiving sensor signals (SS) in a sensor device (21) for detecting boxes (20) being conveyed past the spraying device (1), - receiving box size data (BS), the box size data representing a size of the boxes (20), - automatically determining, based on the box size data and the sensor signals (SS), the speed (S) of the boxes being conveyed past the spraying device (1), and - automatically determining a type (T) and / or number of nozzles (6) to be used for spraying the fluid and / or an, in particular vertical, nozzle position (P) to be set.

1. Name of the product in this design: Animal vaccination station (for veterinary use). 2. Purpose of this design: For vaccinating animals. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of the design product: integrated AI intelligent vaccination chair. 2. The use of the design product: for vaccination chair. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: front view.

The present invention relates to the use of mesenchymal stem cells (MSCs) for enhancing the immune response of elderly or animal subjects to vaccination. According to the application, the defects of spleen stromal cell networks and lymphocyte structures of old subjects can be repaired by applying the MSC in advance, and the immune level of organisms is improved; and the vaccine is injected after a period of time, so that the specific antibody level after vaccine immunization can be improved. The effect can also significantly prevent the elderly subjects from being infected by influenza. Therefore, the MSC has a good application prospect in solving related immune decline of old people.

1. Name of the product in this design: Neonatal Inoculation Table. 2. Purpose of this design: This design is intended for use in administering vaccines to newborns. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A point of care immunization system based upon a range of detection methods to rapidly test a patient in order to ascertain an immunization profile so that vaccinations can be administered to address identified gaps. A point of care system comprised of sample and test strips / cartridges, with said test strips / cartridges configured to meet healthcare requirements of national governing bodies. A point of care system is provided that can function as a stand-alone diagnostic system, a stand-alone kit or with a device.

Provided are methods of biasing a response of a vaccine recipient's immune system toward protective sensitization. Methods include administering an agent or substance to the site of a subject of a temporally interacting cell-mediated allergic reaction to enhance the resulting level of protective sensitization.

Provided are compositions and methods for reducing pre-existing antibodies against viral vector or gene-editing related proteins. The compositions showed reduction in various antibody titers by administration of a liposome composition complexed with a protein or fragment thereof of a viral vector. The liposomes comprise phosphatidylcholine and phosphatidylserine, wherein some or all of the PS is present as lyso-PS. The compositions and methods can be used in conjunction with gene therapy and nucleic acid based vector based vaccinations and therapeutics.

This ultrasonic device comprises: a means for generating a drive signal for driving an ultrasonic transducer that emits ultrasonic waves; and a means for projecting ultrasonic waves based on the drive signal onto the skin of a subject at a vaccine vaccination position, and thereby promoting, in the subject, the production of antibodies by the vaccine.

The present invention relates to coronavirus antigens comprising a coronavirus nucleocapsid specific amino acid sequence, compositions and kits comprising them and methods of production thereof. Further included are methods of using said coronavirus antigens for detecting anti-coronavirus antibodies in a sample, and methods of differentiating between immune responses in a patient caused by a natural coronavirus infection or by vaccination against coronavirus.

The invention discloses a vaccination concentration confirmation method and system for animal husbandry veterinary epidemic prevention, and relates to the technical field of vaccination concentration confirmation. The vaccination concentration confirmation method for animal husbandry and veterinary epidemic prevention comprises the following steps: acquiring vaccine light detection image data and vaccine state detection data of a set animal husbandry and veterinary epidemic prevention vaccine; analyzing a spectral concentration response characteristic value based on a pre-trained spectral concentration sensing model; vaccine state detection data of set animal husbandry and veterinary epidemic prevention vaccines are analyzed and processed to obtain state concentration induction characteristic values, and the state concentration induction characteristic values and spectral concentration response characteristic values are comprehensively processed to obtain vaccine inoculation concentration mapping values. The set animal husbandry veterinary epidemic prevention vaccine is subjected to concentration confirmation treatment based on the vaccination concentration mapping value, so that the concentration result can be kept stable under the conditions of local abnormal interference, non-uniform dilution and the like, and the reliability of vaccine concentration judgment is remarkably improved.

The invention relates to the technical field of data analysis, can be applied to the field of medical health, and provides a vaccine recommendation method and device, equipment and a storage medium. According to the method, the matching degree of a target user and candidate vaccines is determined by obtaining validity scores corresponding to the candidate vaccines, adverse reaction probabilities corresponding to the candidate vaccines, risk probability values of target infectious disease infection of the target user and disease severity, and the target infectious disease is detected according to the matching degree of the target user and various candidate vaccines. When the method is applied to the field of medical health, the accuracy of vaccination can be improved, and the vaccination safety of the user can be guaranteed.

The application discloses an ELISA antibody detection kit for identifying Brucella gene deletion live vaccine (M5-90△26 strain) and wild strains and application. The kit comprises enzyme-linked reaction plate 1 and enzyme-linked reaction plate 2. The enzyme-linked reaction plate 1 is coated with LPS extracted from the Brucella gene deletion live vaccine (M5-90△26 strain), and the enzyme-linked reaction plate 2 is coated with a Brucella BP26 antigen epitope polypeptide combination composed of polypeptides with amino acid sequences shown in SEQ ID NO:1-2. The application is suitable for goats and sheep inoculated with the Brucella gene deletion live vaccine (M5-90△26 strain), can effectively distinguish the antibody produced by the Brucella gene deletion live vaccine (M5-90△26 strain) and the antibody produced by wild strain infection, thereby realizing identification and detection, being favorable for prevention and control of brucellosis and optimization of a vaccination strategy, and providing technical support for healthy and sustainable development of animal husbandry.

The invention discloses a method for scar-free healing in treatment of wounds / wounds by miR-185-5p, relates to the field of biological medicine and plastic surgery and beauty repair, and comprises application of scar-free healing in acute / subacute / chronic wounds related to any skin injury (including burn, laceration, bruise, operation, perforation and vaccination) of deep dermis. Wound healing is a series of complex and elaborately-planned overlapping stages arranged according to a time sequence, wherein the stages comprise four stages of hemostasis, inflammation, proliferation and remodeling. No matter at any stage, the skin stability after wound healing and whether scars are formed or not can be directly influenced. The miR-185-5p is used in an animal skin model caused by an acute wound, so that the wound healing time is integrally shortened, the reepithelization formation of the wound is promoted, the number of skin appendages is increased, and the regeneration of hair follicles is promoted. The secretion amount of the collagen I is reduced, and the formation of the collagen III is improved.

A system and method that enables users to provide authenticated medical records (e.g., vaccination records, viral anti-body test results, etc.) to a third-party (e.g., a venue) to gain access to the third-party is provided. In this way, the third party may confirm that the user is sufficiently immune to a particular disease (e.g., COVID-19) and may thereby minimize the threat of the user introducing the contagious disease to the third party. The system includes a biometric data recognition system that authenticates the identity of a user, a medical records acquisition system that acquires the medical records of the authenticated user, and a system for the displaying or otherwise providing the medical records to the third-party for review. The system also includes a system identification card that includes the user's contact information, alphanumeric characters associated with the user's driver's license number, medical records of the user, and other elements.

This disclosure relates to coronavirus assays, diagnostic methods, treatment methods, and compositions related thereto. In certain embodiments, this disclosure relates to ACE2 receptor binding domain peptides and uses in serological assays and vaccination methods.

Immunotherapeutic Monoclonal Antibody Complexes or Conjugates (IMAC) comprising readily accessible antibodies designed and approved for clinical use are provided using a one-step method that combines killing of existing cancer cells in parallel with induction of long-lasting anti-cancer vaccination. Methods for their use, alone or in combination with cancer killer cells including intentionally mismatched donor T cells, NK cells concomitantly with additional anti-cancer or immune activating agents, or activation of patient's own immune system for personalized treatment of cancer and elimination of undesirable non-malignant cells are also provided. In addition, treatment method based on IMAC can be applied for in vivo vaccination against cancer using an existing malignant lesion as internal anti-cancer vaccine by engagement of patients antigen presenting cells for induction of long-lasting anti-cancer vaccination in situ against residual or recurrent disease.

Engineered filamentous bacteriophage particle are provided, and DNA extracted from such phage particles, including: (a) a filamentous bacteriophage capsid comprising a peptide antigen displayed on a surface of the capsid; and (b) a single stranded DNA molecule (ssDNA) encapsulated within the capsid, wherein the single stranded DNA molecule; wherein (i) the ssDNA comprises at least 12% unmethylated CG dinucleotides; (ii) the ssDNA comprises sequences encoding bacteriophage (A) fl-ori, (B) fl-term, and (C) packaging signal; and (iii) the ssDNA comprises less than 50% bacteriophage ssDNA.

The present disclosure provides a vaccine against cancers that express MHC-II. That includes hormone positive breast cancers and some prostate cancers and melanoma. It is possible, based on a genomic test of the individual, to either (1) design a personal vaccine consisting of a polytope based on epitopes from the TAA that in most cases display on MHC-II and not on MHC-I, or (2) select previously manufactured sequences based on epitopes from the TAA as constituents of the vaccine, such that the cancer after vaccination will reveal itself to the immune system and get eradicated while there are little side effects in that the vaccine will not make the immune system harm the healthy tissue.

The present invention relates to artificial nucleic acid molecules comprising at least one open reading frame and at least one 3'-untranslated region element (3'-UTR element) and / or at least one 5'-untranslated region element (5'-UTR element), wherein said artificial nucleic acid molecule is characterized by a high translation efficiency. Said translation efficiency is at least partially due to said 5'-UTR element or said 3'-UTR element, or due to both said 5'-UTR element and said 3'-UTR element. The present invention further relates to the use of said artificial nucleic acid molecules in gene therapy and / or gene vaccination. Furthermore, novel 3'-UTR elements and 5'-UTR elements are provided.

The present invention provides methods of modulating an immunological disorder or an immune response. The methods include administering to a subject or a cell an effective amount of an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier. Compositions including an autoimmune antigen and an anti-inflammatory cytokine included in an aluminum-based carrier are also provided.

This utility model relates to the field of animal husbandry, and more particularly to a vaccination assistance device for animal husbandry. It includes a limiting frame with a frame door installed on one side. A limiting structure is provided on one side of the limiting frame, and the limiting structure includes a servo motor. The servo motor and the limiting frame are fixedly connected. A first sprocket is fixedly connected to the output end of the servo motor. A chain is driven through the arc surface of the first sprocket. Two connecting blocks are fixedly connected to one side of the limiting frame. The two connecting blocks, close to each other, are rotatably connected to the same screw. The arc surface of the screw has reverse threads at both ends. This utility model provides a vaccination assistance device for animal husbandry that can limit the animal's movement during vaccination, thereby improving vaccination efficiency and increasing personnel safety.