360 results about "Vaccination" patented technology

The invention relates to the field of aquaculture, in particular to a preparation method and application of a larimichthys crocea iridovirus recombinant live vector vaccine. According to the invention, replication-deficient type 5 adenovirus is selected as a target gene expression vector, a recombinant adenovirus vector comprising main capsid protein of iridovirus is constructed, recombinant virus is obtained, and the safe and effective large yellow croaker iridovirus disease recombinant live vector vaccine is created. According to the vaccine, the larimichthys crocea is immunized in a soaking or bait feeding mode, the CPM of the larimichthys crocea immunized by the vaccine is 12.0%, and the CPM of the fish without being immunized by the vaccine is 62.0%. In addition, the RPS of the inoculated fish and the RPS of the empty carrier control group fish are 80.65% and 9.68% respectively. The method is at a leading level in the field of pseudosciaena crocea biomedicine at present, and creativity is remarkable.

The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

The invention discloses an application of kaempferol in preparation of a medicine for treating or preventing PEDV (Porcine Epidemic Diarrhea Virus) infection. The kaempferol can obviously inhibit the replication of the PEDV in Vero and LLC-PK1 cells through 3C-like protease targeting the PEDV, so that the kaempferol can be used for preparing the medicine for preventing and treating the PEDV. Besides, kaempferol, as a natural substance separated from mulberries, can be used as a feed additive for a long time so as to achieve the purpose of preventing epidemic diseases, and does not cause generation of drug-resistant strains and other toxic and side effects after being used for a long time; the defects of immune failure possibly caused by vaccination, virus variation caused by use of antiviral drugs and the like are overcome.

The invention discloses an antigen fusion protein and application thereof in preparation of a live vaccine for preventing infectious bursal disease. Specifically disclosed are antigen fusion proteins comprising a VP2 protein, a trimer tag, and a C3d protein. The invention also discloses recombinant Eimeria heap constructed by using the antigen fusion protein and application of the recombinant Eimeria heap in preparation of IBDV live vaccines. The oocyst of the recombinant Eimeria heap can effectively induce humoral immune response aiming at IBDV as a vaccine active ingredient, the level of an induced antibody is obviously higher than that of an insect strain expressed by a single VP2 antigen, viruses can be more effectively neutralized, the immune protection efficacy is improved, the safety is high, and the oocyst has the potential of serving as a live vector genetic engineering vaccine. The IBDV live vaccine can be orally taken through drinking water or feed, vaccination is simple, large-scale immunization of chicken flocks can be achieved, and the IBDV live vaccine is economical and efficient and has a wide prospect of being applied to prevention and control of the IBDV of the chicken flocks.

The utility model belongs to the technical field of breeding fences, and provides a channel type plateau grazing yak epidemic prevention sampling mating fence which comprises a fence body, a first connecting rod and a second connecting rod. A plurality of first supporting rods and second supporting rods are fixedly connected to the bottom surfaces of the two sets of top rods, a plurality of connecting rods are installed between the two sets of top rods in an array mode, cells are formed between the first supporting rods and the second supporting rods, and surrounding rods are installed in the cells in an array mode; the first door body is fixed at the inlet end of the fence body; the second door body is fixed at the outlet end of the fence body; by arranging the fence body, the first door body and the second door body, the operation efficiency of vaccination, sampling and hybridization is greatly improved, and the current situation that an existing fence is small in yak processing number and low in efficiency is changed.

The invention provides an animal vaccination risk prediction method and system based on a cross-modal large model, and relates to the technical field of vaccination risk prediction. Comprising a multi-modal data acquisition and integration module, a cross-modal feature extraction and semantic alignment module, a pre-training model construction and transfer learning module, a risk prediction and decision support module and a model verification and iterative optimization module. Misjudgment caused by same surface symptoms can be effectively avoided, in animal epidemic disease diagnosis, similar symptoms may be caused by different viruses, a traditional method is easily interfered by surface phenomena, and the optimized method can be used for diagnosis of animal epidemic diseases by constructing a causal diagram, analyzing real causes of symptoms and stripping confounding factors such as environment and physiological status. Through the means, the model can more accurately distinguish virus types, the misjudgment risk is remarkably reduced, and a reliable basis is provided for a subsequent vaccination strategy.

The utility model discloses a poultry vaccination marking mechanism which comprises an ink jet mechanism, the ink jet mechanism is flat and hollow and is connected with an external liquid pump through a hose, one side of the ink jet mechanism is provided with a nozzle, the other side of the ink jet mechanism is rotatably provided with a limiting ball, one end of the limiting ball is connected with a connecting mechanism through a connecting rod, and the other end of the limiting ball is connected with the connecting mechanism. The input end of the liquid pump is connected with an ink box containing marking ink through a pipeline, and the output end of the liquid pump is connected with the ink jetting mechanism through a hose. The trigger switch of the liquid pump can be linked with the vaccine injector, when the vaccine injector is started to inject vaccines once, the liquid pump operates once, a certain amount of ink is sprayed to feathers on poultry bodies, and the ink-jet mechanism is linked with the vaccine injection mechanism to inject the vaccines into the feathers. Meanwhile, the poultry feather marking device is small and exquisite in design, light, simple in structure, low in use and maintenance cost and suitable for small-scale poultry breeding.

The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

The utility model belongs to the technical field of Tibetan pig disease prevention and treatment, particularly relates to a vaccine injector for Tibetan pig disease prevention and treatment, and aims to solve the problems that when vaccine injection is carried out on Tibetan pigs in the same batch of growth stage, workers often hold injectors with hands to go to pigsties to inject the Tibetan pigs one by one, piglets missing vaccine injection are prone to occurring, and potential risks exist. According to the scheme, the device comprises an electric conveying belt, the electric conveying belt is arranged on a channel between two adjacent pigsties, and two guardrails for preventing piglets from falling off are symmetrically arranged above the electric conveying belt. When the piglet vaccine injection device is used, through the design of the electric conveying belt and the guardrails, a worker can conveniently inject vaccines to piglets one by one, and therefore the situation that the piglets are missed to be vaccinated is avoided; through the design of the adjusting assembly, the distance between the guardrails can be adjusted according to the body types of piglets of different growth batches; through the design of the needle-free injection assembly, stress reaction and cross infection risks caused by traditional needle puncture are avoided.

The present invention relates to a composition comprising physiological dendritic cells and at least one mRNA. The invention further relates to a composition comprising physiological dendritic cells and at least one mRNA for vaccination.

The present disclosure introduces an AI-based system (100) and method for predicting the risk of acute exacerbation of chronic obstructive pulmonary disease (COPD) over three months. The system interfaces with consumer devices through REST APIs, ensuring secure communication via HTTPS. Client modules collect and pre-process raw data for integrity and compatibility. This data is then sent to the server (104) which is then transmitted to Input module, the input module (112) authenticates and validates it. The module processes personal details, respiratory history, allergies, vaccination and medication history, and demographic data for air quality analysis. The prediction module (116) uses a CART Model with 90% accuracy to evaluate COPD risk. Based on predefined thresholds, the clinical pathway module (118) and risk prediction response module (120) offer personalized treatment protocols and clinical decision support. The system complies with ISO 13485 standards for safety and reliability.

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

1. The name of the design product: pre-filled syringe (integrated safety type). 2. The use of the design product: injection tools for medical institutions, home care, and vaccination fields. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses an information digital integration system of an edge intelligent mobile hospital, and relates to the technical field of mobile application development. Patient nursing record quantity, vaccination quantity, sickbed use quantity, patient medical record quantity needing to be checked, patient quantity needing to be checked, prescription issuing quantity, stock quantity corresponding to various medicines, use quantity corresponding to various medicines and purchase quantity of various medicines corresponding to an intelligent mobile hospital at a specified edge in a specified area are analyzed; according to the method and the system, the workload evaluation coefficient of nurses, the workload evaluation coefficient of doctors and the drug use evaluation coefficient of each drug in the intelligent mobile hospital at the specified edge of the specified region are calculated, so that the workload of medical staff and the use condition of the drugs can be evaluated more accurately; the mobile hospital can control the cost more accurately, resource waste is avoided, and reasonable control over the cost is achieved.

The invention discloses a spleen-targeted nano platform construction method suitable for tumor vaccination, and particularly relates to the field of vaccines.The spleen-targeted nano platform construction method comprises the steps that S1, CL15H6-DOPS LNPs, spherical polymer vesicles and erythrocyte membrane coated nano-particles are selected as spleen-targeted nano-carriers; s2, integrating an immunologic adjuvant; mn < 2 + > doped LNPs, ultrasonic response lipidosome and a CD3 antibody are selected to be coupled to serve as an integration material; s3, delivering in vivo; animal models are selected for in-vivo delivery and curative effect verification, and B16F10 melanoma mice, MC38 colon cancer mice and non-human primates are selected as the animal models respectively. By optimizing the chain length and the surface topological structure (such as spherical polymer vesicles) of the liposome, the spleen enrichment rate is remarkably increased, and the red marrow myeloid cell uptake efficiency is enhanced. By combining with common delivery of a manganese adjuvant, an STING channel is activated, secretion of type I interferon is promoted, and the proportion of antigen-specific CD8 + T cells and the tumor inhibition rate are increased.

The invention belongs to the technical field of cancer immunotherapy, and particularly relates to iterative radiation-resistant tumor cell debris, a preparation method thereof and an application thereof in tumor resistance. The anti-radiation tumor cells generated by repeated radiation exposure show higher TMB (Tetramethylbenzidine) and induce stronger immunoreaction, so that a personalized vaccine is developed based on the method, and the frozen fragment vaccine is obtained by freeze thawing and inactivation of the radiation-resistant tumor cells. The RR-FDV exhibits enhanced immunogenicity as compared to a conventional radiosensitive counterpart. In the present disclosure, RR-FDV exhibits superior activation of antigen presenting cells, while in vivo, it recruits more dendritic cells to the vaccination site, promotes DC-mediated antigen presentation, and induces stronger antigen-specific T cell toxicity.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The invention discloses a multi-modal data-based vaccination behavior correction method, system and device, and relates to the technical field of vaccination behavior correction, the method comprises the following steps: constructing a multi-modal data sensing module; establishing a multi-modal data processing channel, and collecting inoculation video data, inoculation injection data and inoculation physiological signal data; performing feature extraction to obtain an inoculation visual feature set, an inoculation injection feature set and an inoculation physiological feature set; performing decision level fusion to generate an inoculation behavior feature set; and carrying out abnormity identification and correction prompting on the inoculation behavior feature set, determining inoculation behavior correction information, and carrying out vaccination correction and inoculation whole process recording. The technical problems that in the prior art, no means for standard correction and whole-process recording of vaccination behaviors exist, and vaccination accuracy and safety are difficult to guarantee are solved, and the technical effects that intelligent correction and whole-process recording of the vaccination behaviors are achieved, and vaccination standardization and safety are improved are achieved.

Provided are methods for inducing immune responses against pathogens in a mammal. The methods comprise administering a single cycle adenovirus (SC-Ad) comprising a nucleic acid sequence encoding an immunogen of said pathogen to said mammal. The SC-Ad is administered by inhalation and infects a cell of said mammal, thereby causing expression of said immunogen leading to the induction of said immune response. New infectious virions are not produced. The methods may be of particular utility in vaccination for respiratory pathogens. Corresponding medical uses of the SC-Ads are also provided.

Method for the installation of a spraying device (10) for spraying a fluid (F), in particular a liquid vaccine solution, towards boxes (20) being conveyed past the spraying device, the boxes preferably containing animals, in particular chickens or chicks, to be vaccinated by spray vaccination, the method comprising: - receiving sensor signals (SS) in a sensor device (21) for detecting boxes (20) being conveyed past the spraying device (1), - receiving box size data (BS), the box size data representing a size of the boxes (20), - automatically determining, based on the box size data and the sensor signals (SS), the speed (S) of the boxes being conveyed past the spraying device (1), and - automatically determining a type (T) and / or number of nozzles (6) to be used for spraying the fluid and / or an, in particular vertical, nozzle position (P) to be set.

In one aspect, an EID button tag is provided herein for tagging and identifying cattle as being inoculated against brucellosis, the EID button tag including: a shell having a central opening; a transponder located in the shell; a male punch having a disc-shaped punch body and a stem extending distally therefrom, the stem having a head configured for irreversible insertion into the central opening, wherein a mounting opening is formed through the punch body with a mounting channel extending distally from the mounting opening and coaxially along the stem; and, a vaccination identification button having a disc-shaped visual identification body and a mounting stem extending distally therefrom, wherein the mounting stem is configured for irreversible insertion into the mounting channel. The punch body and the visual identification body are primarily tinted with different colors to provide visual identification of a head of cattle being inoculated against brucellosis.

1. Name of the product in this design: Animal vaccination station (for veterinary use). 2. Purpose of this design: For vaccinating animals. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the field of aquaculture, in particular to a preparation method and application of a recombinant live vector vaccine for infectious hematopoietic necrosis of fish. In order to solve the problem of prevention and control of the infectious hematopoietic necrosis of the fish in the aquatic product industry, a replication-defective adenovirus type 5 is selected as a target gene expression vector to construct a recombinant adenovirus vector comprising a glycoprotein gene and a nucleoprotein gene of the infectious hematopoietic necrosis virus of the fish, and a recombinant virus is obtained; the safe and effective recombinant live vector vaccine for the infectious hematopoietic necrosis of the fish is created. According to the vaccine, immunization is carried out on fishes in a soaking or bait feeding mode, the total CPM of the fishes immunized by the vaccine is 6.67%, and the total CPM of the fishes in a non-immunized control group is 94.00%. In addition, the RPS of the vaccination group fish and the RPS of the empty vector control group fish are 92.90% and 9.22% respectively. The method is at a leading level in the field of fish biological medicines at present and has remarkable creativity.

A system (1) includes an electronic processor (16, 20) integrated with or in wireless communication with an associated monitoring device (10). The electronic processor is programmed to receive physiological sensor data (13) of an associated human subject measured using the associated monitoring device (10); determine whether the associated human subject has indicia of onset an illness by applying a pre-trained artificial intelligence (AI) model (24) to the received physiological sensor data; and output a warning (26) in response to a determination that the associated human subject has indicia of onset of the illness. The pre-trained AI model is pre-trained to determine whether the human subject has received a vaccination.

1. The name of the design product: integrated AI intelligent vaccination chair. 2. The use of the design product: for vaccination chair. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: front view.

The present invention relates to methods for predicting whether peptides or polypeptides comprising disease specific amino acid modifications, in particular tumor-associated neo-antigens, comprise epitopes, in particular tumor-associated neo-epitopes, which are useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.

Provided herein are compositions and methods for the treatment of infectious diseases including COVID and Long COVID. The compositions and methods can be used to treat symptoms relating to infectious disease infection or vaccination as well as for immune system response enhancement to infection and vaccination. A composition includes Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) proteins and / or nucleic acids or functional fragments thereof. A method includes the treatment of infectious diseases such as COVID and long COVID, and for enhancement of immunogenic response to infectious diseases using the compositions disclosed herein.

1. The name of the design product: multifunctional vaccination platform. 2. The use of the design product: intelligent vaccination equipment integrating information registration, vaccine use management, and vaccination. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention relates to the use of mesenchymal stem cells (MSCs) for enhancing the immune response of elderly or animal subjects to vaccination. According to the application, the defects of spleen stromal cell networks and lymphocyte structures of old subjects can be repaired by applying the MSC in advance, and the immune level of organisms is improved; and the vaccine is injected after a period of time, so that the specific antibody level after vaccine immunization can be improved. The effect can also significantly prevent the elderly subjects from being infected by influenza. Therefore, the MSC has a good application prospect in solving related immune decline of old people.