44 results about "Pharmacologic effects" patented technology

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The application discloses application of total flavones of chrysanthemum morifolium ramat and metabolites thereof in preparation of uric acid-lowering or liver and kidney protecting drugs or health care products. The total flavones of chrysanthemum morifolium ramat contain various flavone compounds. In a hyperuricemia model mouse, the total flavones of chrysanthemum morifolium ramat can significantly reduce blood uric acid level, and has a significant protective effect on liver and kidney, and the effect is achieved by inhibiting the activity and expression of xanthine oxidase and adenosine deaminase in the liver, and regulating the expression of uric acid related transporters in the kidney. Meanwhile, metabolites of the total flavones of chrysanthemum morifolium ramat, luteolin-7-O-glucuronide and apigenin-7-O-glucuronide, can also play a pharmacological role in the mouse body. In vitro experiments and mouse primary hepatocytes further prove that luteolin-7-O-glucuronide and apigenin-7-O-glucuronide have an inhibiting effect on the activity and expression level of xanthine oxidase. The application widens the application range of traditional Chinese medicinal materials, and provides a new direction for development of efficient and low-toxic uric acid-lowering and anti-gout drugs or health care products.

The invention discloses application of traditional Chinese medicine monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the same) in preparation of drugs for treating nerve injury diseases and a preparation method of the drugs for treating the nerve injury diseases. The pharmacological action mechanism of the monomer poplar bud flavin is deeply explored, and animal model application effect verification proves that the monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the homologues) can obviously improve core symptoms of cerebral apoplexy, autism, Alzheimer's disease and depression models, is high in safety, and can be used for preparing a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression models. The invention also develops a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression, which takes the poplatin as a core component (including homologues of the poplatin and extracts / mixtures containing the poplatin), and is expected to provide new research results and application schemes for treatment of nerve injury diseases such as cerebral apoplexy, autism, Alzheimer's disease, depression and the like. The important significance is realized on improving the treatment effect.

According to the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the surface stem cells, the brand new pharmacological action of the dipsacus asper saponin VI in targeted promotion of the differentiation of the epidermal stem cells is found for the first time, the cognitive limitation of the prior art is broken through, a brand new target spot and direction are provided for research and development of innovative drugs for wound repair, and the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the epidermal stem cells is realized. A medicine containing teasel saponin VI is adopted, epidermal stem cells are taken as a core target, wound reepithelialization is accelerated by promoting directional differentiation of the epidermal stem cells, the mechanism is clear, the targeting property is high, a core link capable of directly hitting wound healing is adopted, epidermal stem cell differentiation is regulated in a targeted manner, and meanwhile, the medicine has the synergistic effects of resisting inflammation and promoting angiogenesis; the obvious application potential is realized on refractory wounds such as diabetic feet and pressure sores.

This invention provides a novel application of IdeS, which is used to prepare products addressing photoaging of the skin. These products include skincare products and pharmaceuticals for the prevention and / or treatment of photoaging. The pharmaceuticals are in the form of ointments, and the skincare products are used as adjunct treatments for preventing and treating photoaging. IdeS treatment significantly improves the extensive erythema, wrinkles, desquamation, inflammation, and thickened stratum corneum observed in photoaging model mice. It has been developed as a novel biological therapeutic drug with strong pharmacological effects, few side effects, and avoidance of allergic reactions, thus providing a basis for the clinical treatment of photoaging and photodamage.

The present invention relates to a liposome composition for oral administration, the composition comprising a GLP-1 analog. The liposome according to the present invention has both excellent encapsulation efficiency and encapsulation content of the GLP-1 analog drug, and the prepared liposome composition resists digestive enzymes in the gastrointestinal tract and does not easily degrade when administered orally, thus having excellent stability, and has a high absorption rate in the body, and thus exhibits excellent pharmacological effects.

The invention provides application of Laetanine in preparation of a medicine for preventing and / or treating gastric ulcer, and belongs to the technical field of biological medicine. The medicine prepared from the Laetanine has the effects of relieving gastric ulcer pain, reducing the pH value of gastric juice and reducing the ET-1 content in plasma at the same time. Research confirms that the Lapanine can enable the pH value of gastric juice of a rat to tend to a normal value, increase the contents of PGE2 and T-SOD in plasma and reduce the contents of ET-1, TNF-alpha and IL-6 in the plasma, that is, the Lapanine has the effects of relieving gastric ulcer pain, reducing the pH value of the gastric juice and reducing the content of ET-1 in the plasma at the same time, the specific pharmacological action of the Lapanine in gastric ulcer is further confirmed, and a foundation is laid for clinical use.

The present application relates to tetrahydroprotoberberine THPB derivatives, and particularly relates to application of a tetrahydroprotoberberine THPB derivative GP10 in preparation of a medicine for improving or treating epilepsy and neuroinflammation; the new candidate compound GP10 discovered by the present application has significant anti-epilepsy activity, not only expands the pharmacological effect spectrum of THPBs, but also provides a new strategy for research and development of anti-epilepsy drugs or auxiliary treatment drugs. Meanwhile, the present application research proves that GP10 can interfere with the structure of DAMP molecules, affect the combination of DAMP molecules and PRR and the downstream signal transduction, and the mechanism is verified through in-vivo and in-vitro experiments, which provides a new theoretical basis and thought for development of anti-inflammatory drugs.

Provided is a novel compound that is useful as an antiviral drug, exhibits strong drug efficacy in low dosages, can be used safely, and has reverse transcriptase inhibitory activity. This compound is expressed by formula (I) (wherein ring A is (i-a) or (i-b) (where R1 represents a halogen or the like, R2 represents a halogen or the like, R3 represents hydrogen or the like, L represents –O– or the like, R4 represents hydrogen or the like, ring B represents an optionally substituted five-membered or six-membered aromatic heterocycle ring or the like, and n represents an integer of 1-3), and Z is (Z) (where each R6 independently represents a halogen or the like, and m represents an integer of 0-2)).

The invention discloses a Chinese herbal medicine pain-relieving formula and a preparation process thereof, relates to the technical field of traditional Chinese medicines, and solves the technical problems of complex formula, slow effect taking speed and single dosage form in the existing technical scheme. The Chinese herbal medicine pain-relieving formula comprises the following raw materials in parts by weight: 1 part of radix tinosporae, 1 part of sinomenium acutum, 1 part of radix tinosporae and 1 part of sinomenium acutum. The preparation method comprises the following steps: cleaning the raw material medicines of tinospora cordifolia and sinomenium acutum, and removing impurities; carrying out drying treatment on the pretreated raw material medicines; mixing the dried raw material medicines, and crushing into fine powder; the formula provided by the invention is refined, the pharmacological action of each component is clear, and the tinospora cordifolia clears away heat and toxic materials and relieves swelling Sinomenium acutum dispels wind, eliminates dampness, promotes qi circulation and dredges The two medicines are combined to clear heat without damaging yang and promote the circulation of qi without consuming vital energy and act together, so that the dual effects of clearing heat, removing toxicity, promoting the circulation of qi and dredging collaterals are realized; the invention provides a plurality of dosage form choices, so that the formula can flexibly adapt to the requirements of different disease courses, different scenes and different patient groups.

The invention discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors, belongs to the technical field of anti-tumor traditional Chinese medicines, and discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-25 parts of ginseng, 15-18 parts of selfheal, 12-18 parts of seaweed, 12-19 parts of astragalus membranaceus, 10-16 parts of angelica sinensis, 18-30 parts of oldenlandia diffusa, 10-15 parts of fleece-flower root, 10-14 parts of poria cocos, 10-16 parts of thunberg fritillary bulb, 8-14 parts of pseudobulbus cremastrae seu pleiones and 8-17 parts of curcuma zedoary. Through the specific pharmacological action, growth and proliferation of thyroid tumor cells are inhibited, the development speed of tumors can be slowed down, the malignancy degree of the tumors can be reduced, apoptosis of the thyroid tumor cells can be induced, and the number of the tumor cells can be effectively reduced by inducing apoptosis of the tumor cells, so that the anti-tumor purpose is achieved.

The invention discloses a traditional Chinese medicine compound beewax thermal therapy transdermal drug product as well as preparation and application thereof, and belongs to the technical field of external treatment of traditional Chinese medicines. The product is composed of 70%-90% of natural beeswax and 10%-30% of a traditional Chinese medicine compound, and the traditional Chinese medicine compound is selected from medicines for promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and the like according to indications; the preparation method comprises the steps of traditional Chinese medicine pretreatment, beewax melting, medicine mixing and forming. During application, treatment is completed through medicinal wax heating, skin pretreatment, medicinal wax application, treatment maintenance and subsequent treatment. The physical effect of beeswax thermal therapy and the pharmacological effect of traditional Chinese medicine are synergistically combined, the continuous thermal effect of beeswax can promote blood circulation, improve the transdermal efficiency of the medicine and enhance the activity of the medicine, and the curative effect is remarkable; the natural beewax is good in biocompatibility, gastrointestinal tract stimulation and the first-pass effect of the liver are avoided through transdermal drug delivery, and the safety is high; the medicine is standardized in preparation, simple and convenient to operate, suitable for primary medicine and families, capable of treating various diseases such as painful diseases and soft tissue injury and high in clinical application value.

The present invention relates to a thioether compound having soft drug properties, and a pharmaceutical composition and use thereof. The compound has a structure of formula I. The thioether structure of the compound of the present invention has pharmacological activity, and after exerting pharmacological effects, it is rapidly converted into sulfoxide and sulfone metabolites that do not have pharmacological activity according to an established metabolic pathway, so that it can be achieved that the toxicity of prototype drugs, active metabolites and reactive metabolites to a body is avoided while exerting therapeutic effects, and the safety is relatively higher

The invention discloses application of ethyl sulfate in preparation of a medicine for preventing and / or treating inflammatory bowel diseases, and belongs to the technical field of medicines. The invention finds that ethyl sulfate has the effect of preventing and / or treating inflammatory bowel disease for the first time: the ethyl sulfate can obviously improve the survival index of an inflammatory bowel disease model mouse and reduce the disease activity index; the symptoms of weight loss, stool character, inflammation-related diarrhea and bloody stool are relieved; the length of colon tissue is improved, and the size and number of tumors in colorectum are reduced; the pharmaceutical composition has the effects of inhibiting the level of proinflammatory cytokines (TNF-alpha, IL-8, IL-1beta and IL-6), recovering the level of anti-inflammatory cytokines (IL-10 and INF-gamma), inhibiting the enzymatic activity of MPO and MDA and improving the enzymatic activity of SOD and GSH-Px, so that the inflammatory reaction and oxidative stress reaction in the inflammatory bowel disease microenvironment are improved, and the pharmaceutical composition has the pharmacological action of preventing and / or treating the inflammatory bowel disease.

The invention discloses a traditional Chinese medicine composition for treating tumors caused by internal stagnation of toxic blood stasis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 47-49 parts of longpimpinella pedicularis, 24-26 parts of black ants and 24-26 parts of toad skin. According to the invention, only the three medicinal materials, namely Longdiland, black ant and toad skin, are adopted, the formula is simple, the medicinal materials are wide in source and controllable in cost, the pharmacological actions of the three medicinal materials are complementary, Longdiland enhances immunity and resists inflammation, black ant regulates immunity, resists inflammation and relieves pain, toad skin directly plays an anti-tumor role, the effects of attacking hard mass, breaking stasis, resisting cancer and diminishing swelling are realized, and a precise formula is prepared aiming at the pathogenesis of internal stagnation of toxic blood stasis; clinical verifications prove that the traditional Chinese medicine can effectively relieve clinical symptoms of tumors caused by internal accumulation of toxic stasis and control recurrence and metastasis of the tumors; meanwhile, the body immunity of patients is improved, the life quality is improved, the survival time is prolonged, and compared with existing partial traditional Chinese medicine preparations, the curative effect is clearer, and the pertinence is higher. The invention further discloses a preparation method of the traditional Chinese medicine composition.

The application discloses application of a compound in preparation of a medicine for treating androgen alopecia, and relates to the technical field of biological medicines. The foreskin mesenchymal stem cell extracellular small vesicle has water-soluble and fat-soluble double-soluble characteristics, can be absorbed through the skin, and is administered in a manner of intravenous administration / mist administration and the like. The foreskin mesenchymal stem cell extracellular small vesicle is used as a carrier to load curcumin, so that the absorption of the curcumin can be effectively improved, the pharmacological effect of the curcumin can be improved, and the targeting and anti-inflammatory efficiency can be improved. Moreover, the compound obtained by loading the foreskin mesenchymal stem cell extracellular small vesicle with curcumin can easily penetrate into the skin, directly acts on the hair follicles damaged by androgen, has a good effect of treating androgen alopecia, and can significantly promote hair regeneration.

This application relates to the field of pharmaceutical preparations, and discloses a compound preparation composition containing olopatadine and brimonidine for nasal use, and its preparation method. The compound preparation composition for nasal use comprises 0.01-0.5% olopatadine and 0.01-0.5% brimonidine by weight percentage. The compound preparation composition of this invention, with olopatadine and brimonidine used in combination, significantly improves efficacy compared to monotherapy, showing a good synergistic effect, and achieves multiple pharmacological effects with a single dose, greatly improving the convenience of medication and long-term treatment compliance.

The invention provides an essential oil composition. The essential oil composition is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of safflower essential oil, 0.5-1.5 parts of ligusticum wallichii essential oil and 0.5-1.5 parts of angelica sinensis essential oil. The invention also provides application of the essential oil composition in preparation of external medicines for preventing or / treating qi-blood disorder. According to the invention, a synergistic effect mechanism of medicine and massage is adopted, on one hand, pharmacological action is exerted through percutaneous absorption of active substances such as essential oil, and on the other hand, local blood circulation is remarkably promoted, muscle spasm is relieved and medicine permeation efficiency is enhanced by means of a massage technique, so that deep fusion of medicine effect and physical treatment effect is realized, and the traditional Chinese medicine composition takes effect quickly and lasts long; the essential oil raw materials are combined, so that the synergistic interaction effect is achieved; the first-pass effect and gastrointestinal tract adverse reaction can be effectively avoided, and the composition is high in safety and suitable for long-term use.

The invention belongs to the technical field of chemical synthesis of medicines, and particularly relates to a preparation process of azelastine hydrochloride, which comprises four steps of condensation reduction, hydrochloric acid hydrolysis, cyclization and hydrochloric acid salification. According to the method, the reaction efficiency, the product yield and the purity are improved, the production cost and the operation difficulty are reduced, and a stable, cost-controllable and repeatable preparation process is formed. The prepared azelastine hydrochloride is a long-acting anti-allergic drug, has dual effects of resisting histamine and inflammation, has high affinity to a receptor, effectively blocks histamine release of mast cells and basic granulocytes, has wide pharmacological effects on leukotriene, kinin, platelet activating factors and other inflammatory chemical mediators, and can be used for preparing an anti-allergic drug. Therefore, azelastine can effectively relieve typical symptoms of allergic conjunctivitis, such as pruritus, conjunctival congestion, lacrimation, conjunctival edema and the like.

This invention discloses the application of Hispidin in the preparation of FXR antagonists, belonging to the field of biomedical technology. This invention provides the application of Hispidin in the preparation of FXR antagonists. Hispidin can target and bind to FXR and possesses FXR antagonistic activity, thereby reversing the pathological signaling pathways caused by excessive FXR activation. This invention expands the new pharmacological effects and applications of Hispidin, not only providing new candidates for the regulation of FXR-related signaling pathways, but also offering new research directions for the development of drugs for the prevention and treatment of bile acid metabolism disorders, lipid metabolism disorders, glucose metabolism disorders, and related diseases, demonstrating promising application prospects.

A liquid preparation and a method for preparing the liquid preparation are disclosed. The liquid preparation contains a high-concentration L-serine or a pharmaceutically acceptable salt thereof, and shows an excellent stability and safety. The liquid preparation exhibits excellent pharmacological effects and is suitable for preventing or treating a central nervous system disease.

The invention provides a linear mucopolysaccharide substance taking hyaluronic acid as a parent structure and a preparation method of the linear mucopolysaccharide substance, and belongs to the technical field of medicines. The invention relates to a linear mucopolysaccharide substance with hyaluronic acid as a parent structure, which is formed by repeatedly connecting glucuronic acid and N-acetylglucosamine as disaccharide units, and a preparation method of the linear mucopolysaccharide substance. A repeatedly-connected structural unit in the linear mucopolysaccharide substance is a combined structure which is shown in a formula (1) and synthesized by disaccharide units in hyaluronic acid and alkaline organic compounds acceptable to a human body or base groups of the alkaline organic compounds. The hyaluronic acid linear mucopolysaccharide substance does not change the basic parent structure of the conventional hyaluronic acid and does not touch the problem of quality control of new drugs, and the alkaline organic compound or the group thereof can be selected from a compound or a component with biological activity / pharmacological action, so that the curative effect can be improved, and the cost can be reduced. And individual medication selection requirements of different patients can be met.

The invention belongs to the field of traditional Chinese medicine, and particularly discloses an embedded suture prepared from horsetail hair and application of the embedded suture to preparation of a medicine for treating facioplegia, and the embedded suture is prepared from tail hair of equine animals; the tail hair of equus animals is prepared into an embedded suture product, the embedded suture can provide lasting and stable treatment stimulation in vivo, a patient can maintain the curative effect for a long time after receiving the embedded suture treatment once, frequent treatment is not needed, meanwhile, the embedded suture serves as a traditional Chinese medicine raw material, effective components are slowly released in vivo, and the curative effect is good. According to the present invention, the formula is reasonable, the pharmacological effects of heat clearing, detoxification, channel clearing and collateral activating are performed, the rehabilitation is promoted, the perfect combination of physical stimulation and pharmaceutical chemical stimulation is achieved, the main component of the horsetail hair is keratin, the compatibility with the human tissue is good, the material cost is low, the treatment cost is reduced, and the extremely high hygienic economic benefit is provided.

The invention belongs to the technical field of traditional Chinese medicine extraction and medicine, and particularly relates to an anthraquinone compound and an extraction method and application thereof. The anthraquinone compound is extracted from oldenlandia diffusa. The invention provides an anthraquinone compound extracted from oldenlandia diffusa, and the anthraquinone compound has a novel structure and pharmacological activity, and provides a material basis for research on the medical effect of the oldenlandia diffusa. The data result of the embodiment of the invention shows that the anti-leukemia effect of the anthraquinone compound provided by the invention provides a powerful basis for exploring potential anti-leukemia new drugs. In addition, the invention also provides a method for preparing the compound from oldenlandia diffusa, and the whole preparation process is simple to operate, easy to control and suitable for industrial production.

The invention relates to the technical field of new pharmacological action of a compound Nxa, and particularly discloses application of the compound Nxa in preparation of a medicine for treating Alzheimer's disease and a medicine composition of the compound Nxa. The chemical name of the compound Nxa is 2, 3, 4, 4 '-tetrahydroxybenzophenone-1, 2-diazido naphthoquinone-5-sulfonate, the molecular formula of the compound Nxa is C22H18O11, the new application of the compound Nxa in treatment of the Alzheimer's disease fills the blank in the field of micromolecule GLP-1 RA special for treating AD, and a new drug choice is provided for treatment and alleviation of the Alzheimer's disease.

This invention discloses a dihydroquercetin cocrystal, its preparation method, and its applications. The dihydroquercetin cocrystal is prepared by combining dihydroquercetin extracted from species such as Siberian larch with small molecule substances, including betaine, L-proline, benzamide, nicotinamide, or isonicotinine. The dihydroquercetin cocrystal of this invention exhibits high thermal stability and higher apparent solubility and dissolution rate compared to dihydroquercetin itself. This facilitates the full utilization of dihydroquercetin's various pharmacological effects, such as antioxidant, antitumor, anti-apoptotic, anti-inflammatory, cardiomyocyte protection, hypoglycemic, improvement of vascular endothelial cell function, antiplatelet aggregation, and influence on bone metabolism. Furthermore, the preparation method is simple, allowing for large-scale industrial production and offering significant economic benefits.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating headache and a preparation method thereof. According to the treatment principle, concha haliotidis and gastrodia elata have the effects of calming the liver, suppressing yang, dispelling wind and relieving pain, mother-of-pearl has the effects of calming the liver, suppressing yang, soothing the nerves and arresting convulsion, cape jasmine is bitter and cold in taste and can clear away heat of the heart, the lung and triple jiao, fried tribulus terrestris has the effects of calming the liver, relieving depression and promoting blood circulation to dispel wind, ligusticum wallichii and radix saposhnikoviae have the effects of dispelling wind and relieving pain, angelica sinensis has the effects of promoting blood circulation to remove blood stasis and dredging collaterals, cynanchum paniculatum has the effects of dispelling wind, resolving dampness and relieving pain, and pollen typhae has the effects of stopping bleeding and relieving pain. Radix angelicae has the effects of dispelling wind and relieving pain; animal experiments show that the traditional Chinese medicine composition obviously prolongs the appearance time of red ears, shortens the disappearance time of the red ears, obviously reduces the scratching frequency, can improve behavioral symptoms of rat migraine caused by nitroglycerin, plays a pharmacological role in treating the migraine, and provides a safe and efficient treatment scheme for the migraine.

The application discloses a traditional Chinese medicine capsule of Herba Epimedii and Radix Morindae Officinalis and a preparation method thereof, relates to the technical field of traditional Chinese medicine preparations, and overcomes the defects of single-component preparation target, large side effect of hormone-containing drugs and unreasonable traditional compound prescription, etc.

The invention discloses application of Auranofin in preparation of a medicine for preventing and / or treating ischemic cardiomyopathy and heart failure, and belongs to the field of biological medicine. In-vivo and in-vitro experiments prove that the Auranofin can remarkably improve cardiac function indexes after myocardial ischemia reperfusion injury, so that the Auranofin has a definite pharmacological action in the aspects of preventing and treating ischemic cardiomyopathy and heart failure, a new candidate scheme is provided for the drug treatment of the diseases, and the application of the Auranofin in the treatment of ischemic cardiomyopathy and heart failure is developed. Meanwhile, the application prospect of the Auranofin in the field of cardiovascular diseases is expanded, and the Auranofin has important theoretical value and clinical transformation potential.