72 results about "Pharmacologic effects" patented technology

The application discloses a bacteriostatic and acne-removing microemulsion containing plant extracts and a preparation method thereof. The bacteriostatic and acne-removing microemulsion contains a microemulsion loaded with quercetin alone, a microemulsion loaded with sasanquasapernin alone, and a microemulsion loaded with quercetin and sasanquasapernin simultaneously. The bacteriostatic and acne-removing microemulsion containing plant extracts prepared by the application not only solves the problems of stickiness of camellia oil and poor solubility of quercetin, but also has a synergistic inhibitory effect on propionibacterium acnes, achieves the same high-efficiency bacteriostatic effect with a lower drug concentration, saves drug cost, reduces drug irritation, and expands the application of quercetin and sasanquasapernin in the cosmetic and pharmaceutical fields due to the rich pharmacological effect of the plant extracts, low side effect and safety. The microemulsion system prepared by the application is clear, transparent, uniform and stable, the preparation process is simple, the required energy is low, the cost is low, and the system is beneficial to commercial production.

The invention relates to the technical field of health-care food, in particular to a freckle-removing and whitening traditional Chinese medicine composition, a preparation method thereof and freckle-removing and whitening nourishment. Effective components of the freckle-removing and whitening traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 2-6 parts of peach kernels, 1-5 parts of Chinese wolfberry fruits, 1-5 parts of longan aril, 1-5 parts of Chinese dates, 1-4 parts of lily bulbs, 0.5-4 parts of mulberries, 0.2-2.5 parts of poria cocos and 0.1-0.6 part of double-petal red roses. The freckle-removing and whitening traditional Chinese medicine composition has the effect of accelerating melanin dissolution so as to achieve the good effects of removing freckles and whitening the skin color. Meanwhile, the freckle-removing and whitening traditional Chinese medicine composition disclosed by the invention is good in safety, edible, capable of exerting the pharmacological action and synergistic interaction of all the components and multiple in benefits.

The invention discloses a tetrandrine ferulate and its application in the preparation of a medicament for treating pulmonary fibrosis. The pharmacological effects of tetrandrine and ferulic acid, as well as those after salification, are studied. It is found that both have an anti-pulmonary fibrosis effect, and the two can be used in combination to synergistically exert a more excellent anti-pulmonary fibrosis efficacy. At the same time, the solubility of tetrandrine can also be increased. This has not been reported in existing literature. The tetrandrine ferulate of the present invention has lower cytotoxicity, and the cell viability of normal human liver cells LO-2 and human embryonic fibroblasts MRC-5 is higher than that of tetrandrine, which alleviates the burden of liver and lungs to a certain extent and has good safety.

The application discloses application of total flavones of chrysanthemum morifolium ramat and metabolites thereof in preparation of uric acid-lowering or liver and kidney protecting drugs or health care products. The total flavones of chrysanthemum morifolium ramat contain various flavone compounds. In a hyperuricemia model mouse, the total flavones of chrysanthemum morifolium ramat can significantly reduce blood uric acid level, and has a significant protective effect on liver and kidney, and the effect is achieved by inhibiting the activity and expression of xanthine oxidase and adenosine deaminase in the liver, and regulating the expression of uric acid related transporters in the kidney. Meanwhile, metabolites of the total flavones of chrysanthemum morifolium ramat, luteolin-7-O-glucuronide and apigenin-7-O-glucuronide, can also play a pharmacological role in the mouse body. In vitro experiments and mouse primary hepatocytes further prove that luteolin-7-O-glucuronide and apigenin-7-O-glucuronide have an inhibiting effect on the activity and expression level of xanthine oxidase. The application widens the application range of traditional Chinese medicinal materials, and provides a new direction for development of efficient and low-toxic uric acid-lowering and anti-gout drugs or health care products.

The present invention discloses a method for extracting effective active ingredients from Buddleja buddhist flower and its application. The method comprises the following steps: first subjecting the crushed Buddleja buddhist flower to ethanol reflux extraction and concentration, and then extracting the obtained Buddleja buddhist flower alcohol extract with petroleum ether, ethyl acetate, and n-butanol respectively. The remaining aqueous phase is concentrated under reduced pressure, purified by a D101 macroporous resin column, and the target product obtained after drying is structurally identified as a verbascoside monomer compound. The method of the present invention can better control the quality standards of Buddleja buddhist flower and pave the way for a more in-depth study of its pharmacological effects by effectively separating the verbascoside compounds from the Buddleja buddhist flower, thereby laying the foundation for the clinical development of new drugs with anti-tumor, antioxidant, and immunomodulatory activities.

The present invention discloses a liquid formulation of L-serine or a pharmaceutically acceptable salt thereof and a method for preparing the same. Specifically, the present invention relates to a liquid formulation and a method for preparing the same, wherein the liquid formulation comprises a high concentration of L-serine or a pharmaceutically acceptable salt thereof, has excellent stability and safety, and exhibits excellent pharmacological effects.

The invention discloses application of traditional Chinese medicine monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the same) in preparation of drugs for treating nerve injury diseases and a preparation method of the drugs for treating the nerve injury diseases. The pharmacological action mechanism of the monomer poplar bud flavin is deeply explored, and animal model application effect verification proves that the monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the homologues) can obviously improve core symptoms of cerebral apoplexy, autism, Alzheimer's disease and depression models, is high in safety, and can be used for preparing a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression models. The invention also develops a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression, which takes the poplatin as a core component (including homologues of the poplatin and extracts / mixtures containing the poplatin), and is expected to provide new research results and application schemes for treatment of nerve injury diseases such as cerebral apoplexy, autism, Alzheimer's disease, depression and the like. The important significance is realized on improving the treatment effect.

According to the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the surface stem cells, the brand new pharmacological action of the dipsacus asper saponin VI in targeted promotion of the differentiation of the epidermal stem cells is found for the first time, the cognitive limitation of the prior art is broken through, a brand new target spot and direction are provided for research and development of innovative drugs for wound repair, and the application of the dipsacus asper saponin VI in regulating and controlling the differentiation of the epidermal stem cells is realized. A medicine containing teasel saponin VI is adopted, epidermal stem cells are taken as a core target, wound reepithelialization is accelerated by promoting directional differentiation of the epidermal stem cells, the mechanism is clear, the targeting property is high, a core link capable of directly hitting wound healing is adopted, epidermal stem cell differentiation is regulated in a targeted manner, and meanwhile, the medicine has the synergistic effects of resisting inflammation and promoting angiogenesis; the obvious application potential is realized on refractory wounds such as diabetic feet and pressure sores.

This invention provides a novel application of IdeS, which is used to prepare products addressing photoaging of the skin. These products include skincare products and pharmaceuticals for the prevention and / or treatment of photoaging. The pharmaceuticals are in the form of ointments, and the skincare products are used as adjunct treatments for preventing and treating photoaging. IdeS treatment significantly improves the extensive erythema, wrinkles, desquamation, inflammation, and thickened stratum corneum observed in photoaging model mice. It has been developed as a novel biological therapeutic drug with strong pharmacological effects, few side effects, and avoidance of allergic reactions, thus providing a basis for the clinical treatment of photoaging and photodamage.

The present invention relates to a liposome composition for oral administration, the composition comprising a GLP-1 analog. The liposome according to the present invention has both excellent encapsulation efficiency and encapsulation content of the GLP-1 analog drug, and the prepared liposome composition resists digestive enzymes in the gastrointestinal tract and does not easily degrade when administered orally, thus having excellent stability, and has a high absorption rate in the body, and thus exhibits excellent pharmacological effects.

The invention provides application of Laetanine in preparation of a medicine for preventing and / or treating gastric ulcer, and belongs to the technical field of biological medicine. The medicine prepared from the Laetanine has the effects of relieving gastric ulcer pain, reducing the pH value of gastric juice and reducing the ET-1 content in plasma at the same time. Research confirms that the Lapanine can enable the pH value of gastric juice of a rat to tend to a normal value, increase the contents of PGE2 and T-SOD in plasma and reduce the contents of ET-1, TNF-alpha and IL-6 in the plasma, that is, the Lapanine has the effects of relieving gastric ulcer pain, reducing the pH value of the gastric juice and reducing the content of ET-1 in the plasma at the same time, the specific pharmacological action of the Lapanine in gastric ulcer is further confirmed, and a foundation is laid for clinical use.

The present application relates to tetrahydroprotoberberine THPB derivatives, and particularly relates to application of a tetrahydroprotoberberine THPB derivative GP10 in preparation of a medicine for improving or treating epilepsy and neuroinflammation; the new candidate compound GP10 discovered by the present application has significant anti-epilepsy activity, not only expands the pharmacological effect spectrum of THPBs, but also provides a new strategy for research and development of anti-epilepsy drugs or auxiliary treatment drugs. Meanwhile, the present application research proves that GP10 can interfere with the structure of DAMP molecules, affect the combination of DAMP molecules and PRR and the downstream signal transduction, and the mechanism is verified through in-vivo and in-vitro experiments, which provides a new theoretical basis and thought for development of anti-inflammatory drugs.

The present invention relates to a sustained-release pharmaceutical composition using a GLP-1 receptor agonist. Specifically, microparticles comprising semaglutide are prepared using a 5-hydroxydopamine-modified self-crosslinkable hyaluronic acid derivative (SAMH) as a carrier, and the semaglutide is gradually released over a long period of time upon injection into the body, thereby providing excellent effects on blood glucose control and weight management. The sustained-release pharmaceutical composition according to the present invention maintains a low viscosity before administration to the human body, thus being easily administered by injection, and is self-crosslinked and hydrogelated after administration to the human body, and thus can maintain the pharmacological effect of the semaglutide for a long period of time with only a single administration.

Provided is a novel compound that is useful as an antiviral drug, exhibits strong drug efficacy in low dosages, can be used safely, and has reverse transcriptase inhibitory activity. This compound is expressed by formula (I) (wherein ring A is (i-a) or (i-b) (where R1 represents a halogen or the like, R2 represents a halogen or the like, R3 represents hydrogen or the like, L represents –O– or the like, R4 represents hydrogen or the like, ring B represents an optionally substituted five-membered or six-membered aromatic heterocycle ring or the like, and n represents an integer of 1-3), and Z is (Z) (where each R6 independently represents a halogen or the like, and m represents an integer of 0-2)).

The invention discloses a Chinese herbal medicine pain-relieving formula and a preparation process thereof, relates to the technical field of traditional Chinese medicines, and solves the technical problems of complex formula, slow effect taking speed and single dosage form in the existing technical scheme. The Chinese herbal medicine pain-relieving formula comprises the following raw materials in parts by weight: 1 part of radix tinosporae, 1 part of sinomenium acutum, 1 part of radix tinosporae and 1 part of sinomenium acutum. The preparation method comprises the following steps: cleaning the raw material medicines of tinospora cordifolia and sinomenium acutum, and removing impurities; carrying out drying treatment on the pretreated raw material medicines; mixing the dried raw material medicines, and crushing into fine powder; the formula provided by the invention is refined, the pharmacological action of each component is clear, and the tinospora cordifolia clears away heat and toxic materials and relieves swelling Sinomenium acutum dispels wind, eliminates dampness, promotes qi circulation and dredges The two medicines are combined to clear heat without damaging yang and promote the circulation of qi without consuming vital energy and act together, so that the dual effects of clearing heat, removing toxicity, promoting the circulation of qi and dredging collaterals are realized; the invention provides a plurality of dosage form choices, so that the formula can flexibly adapt to the requirements of different disease courses, different scenes and different patient groups.

The invention discloses a gemfibrozil deuterated derivative as shown in a formula (I) as well as a preparation method and application thereof, and belongs to the field of organic and pharmaceutical synthesis. The method is simple in preparation process and low in cost. The gemfibrozil deuterated derivative synthesized by the method has the advantages of high purity and high deuterated rate. The invention also discloses an application of the gemfibrozil deuterated derivative in treatment of hyperlipidemia. The pharmacological action of the gemfibrozil deuterated derivative disclosed by the invention is obviously improved, and toxic metabolites of the gemfibrozil deuterated derivative are obviously reduced.

The invention discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors, belongs to the technical field of anti-tumor traditional Chinese medicines, and discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-25 parts of ginseng, 15-18 parts of selfheal, 12-18 parts of seaweed, 12-19 parts of astragalus membranaceus, 10-16 parts of angelica sinensis, 18-30 parts of oldenlandia diffusa, 10-15 parts of fleece-flower root, 10-14 parts of poria cocos, 10-16 parts of thunberg fritillary bulb, 8-14 parts of pseudobulbus cremastrae seu pleiones and 8-17 parts of curcuma zedoary. Through the specific pharmacological action, growth and proliferation of thyroid tumor cells are inhibited, the development speed of tumors can be slowed down, the malignancy degree of the tumors can be reduced, apoptosis of the thyroid tumor cells can be induced, and the number of the tumor cells can be effectively reduced by inducing apoptosis of the tumor cells, so that the anti-tumor purpose is achieved.

The application discloses application of a glycosyltransferase Bs-YjiC in Bacillus subtilis 168 and comprises the following steps: catalyzing reaction of ginsenoside Rg2, the glycosyltransferase Bs-YjiC and uridine diphosphate glucose, so as to glycosylate C 20 hydroxyl group of the ginsenoside Rg2 to generate ginsenoside Re; or catalyzing reaction of notoginsenoside R2, the glycosyltransferase Bs-YjiC and uridine diphosphate glucose, so as to glycosylate C 20 hydroxyl group of the notoginsenoside R2 to generate notoginsenoside R1; the application utilizes the glycosyltransferase Bs-YjiC of microbial origin to catalyze C 20 hydroxyl group glycosylation of the ginsenoside Rg2 or the notoginsenoside R2, and since the ginsenoside Re and the notoginsenoside R1 have important pharmacological effects, the glycosyltransferase Bs-YjiC of microbial origin can be utilized to catalyze synthesis of the ginsenoside Re and the notoginsenoside R1 beneficial to human health.

The invention belongs to the field of solid beverages, and provides a sophora flower and kudzuvine root composite solid beverage and a preparation method thereof.The solid beverage is prepared from 15-45 parts of sophora flower extract, 25-65 parts of kudzuvine root extract, 5-15 parts of prebiotics mixture, 1-10 parts of natural flavoring agent, 0.5-5 parts of auxiliary materials and 1-8 parts of antioxidant ingredients; according to the sophora flower and kudzuvine root composite solid beverage provided by the invention, various raw material components are scientifically proportioned, so that the traditional pharmacological effects of sophora flowers and kudzuvine roots are reserved, various health elements are also blended, the intestinal health and immunity are remarkably enhanced, and meanwhile, natural plant extracts are added as auxiliary components, so that the health-care effect is good. The flos sophorae, the radix puerariae and the prebiotic composition form a synergistic effect, so that the effects of the beverage in the aspects of cardiovascular protection, oxidation resistance and inflammation resistance are further improved, and more comprehensive health support is provided for consumers.

The application discloses a chemical structural formula of a biphenyl sulfonamide compound of a bis-benzimidazole, and also discloses application of the compound in preparation of a pharmaceutically acceptable salt or solvate, application of the compound and the pharmaceutically acceptable salt or solvate in preparation of a medicine for treating endothelin-dependent or angiotensin II-dependent diseases. Meanwhile, the biphenyl sulfonamide compound of the bis-benzimidazole can also be used in combination by changing substituted functional groups. The biphenyl sulfonamide compound of the bis-benzimidazole, the prepared pharmaceutically acceptable salt or solvate and the medicine prepared by the compound have pharmacological activities, and have pharmacological effects in animals including human beings, and are particularly useful in treatment or prevention of IgA nephropathy, focal segmental glomerulosclerosis, nephrotic syndrome, chronic kidney disease, diabetic nephropathy, hypertension, coronary heart disease and myocardial infarction.

The invention discloses a traditional Chinese medicine compound beewax thermal therapy transdermal drug product as well as preparation and application thereof, and belongs to the technical field of external treatment of traditional Chinese medicines. The product is composed of 70%-90% of natural beeswax and 10%-30% of a traditional Chinese medicine compound, and the traditional Chinese medicine compound is selected from medicines for promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and the like according to indications; the preparation method comprises the steps of traditional Chinese medicine pretreatment, beewax melting, medicine mixing and forming. During application, treatment is completed through medicinal wax heating, skin pretreatment, medicinal wax application, treatment maintenance and subsequent treatment. The physical effect of beeswax thermal therapy and the pharmacological effect of traditional Chinese medicine are synergistically combined, the continuous thermal effect of beeswax can promote blood circulation, improve the transdermal efficiency of the medicine and enhance the activity of the medicine, and the curative effect is remarkable; the natural beewax is good in biocompatibility, gastrointestinal tract stimulation and the first-pass effect of the liver are avoided through transdermal drug delivery, and the safety is high; the medicine is standardized in preparation, simple and convenient to operate, suitable for primary medicine and families, capable of treating various diseases such as painful diseases and soft tissue injury and high in clinical application value.

The present invention relates to a thioether compound having soft drug properties, and a pharmaceutical composition and use thereof. The compound has a structure of formula I. The thioether structure of the compound of the present invention has pharmacological activity, and after exerting pharmacological effects, it is rapidly converted into sulfoxide and sulfone metabolites that do not have pharmacological activity according to an established metabolic pathway, so that it can be achieved that the toxicity of prototype drugs, active metabolites and reactive metabolites to a body is avoided while exerting therapeutic effects, and the safety is relatively higher

The invention discloses application of ethyl sulfate in preparation of a medicine for preventing and / or treating inflammatory bowel diseases, and belongs to the technical field of medicines. The invention finds that ethyl sulfate has the effect of preventing and / or treating inflammatory bowel disease for the first time: the ethyl sulfate can obviously improve the survival index of an inflammatory bowel disease model mouse and reduce the disease activity index; the symptoms of weight loss, stool character, inflammation-related diarrhea and bloody stool are relieved; the length of colon tissue is improved, and the size and number of tumors in colorectum are reduced; the pharmaceutical composition has the effects of inhibiting the level of proinflammatory cytokines (TNF-alpha, IL-8, IL-1beta and IL-6), recovering the level of anti-inflammatory cytokines (IL-10 and INF-gamma), inhibiting the enzymatic activity of MPO and MDA and improving the enzymatic activity of SOD and GSH-Px, so that the inflammatory reaction and oxidative stress reaction in the inflammatory bowel disease microenvironment are improved, and the pharmaceutical composition has the pharmacological action of preventing and / or treating the inflammatory bowel disease.

The present invention provides the use of chlorogenic acid in the preparation of a drug for preventing and treating aortic dissection. By establishing a recognized animal disease model, the pharmacological effects of chlorogenic acid are studied, and it is found and verified that chlorogenic acid has the effects of reducing the morbidity and mortality of aortic dissection; slowing down aortic dilation; and protecting the smooth muscle layer. This proves the use of chlorogenic acid in preventing and treating aortic dissection, and provides a solid pharmacodynamic basis for new clinical research and application of the drug.

The invention discloses a stent based on a full-drug-based structure function integrated composite coating and a preparation method and application thereof, and belongs to the technical field of medical instruments.The stent comprises a stent body, tannic acid coatings and EP-C9 polypeptide coatings are sequentially arranged on the outer surface of the stent body from inside to outside, the tannic acid coatings and the EP-C9 polypeptide coatings are alternately arranged, and the tannic acid coatings and the EP-C9 polypeptide coatings are sequentially arranged on the outer surface of the stent body from inside to outside. One tannic acid coating and one EP-C9 polypeptide coating are marked as one group, N groups are arranged in total, and N is greater than or equal to 1. The stent has excellent antithrombotic and anti-inflammatory functions and has no carrier residue side effect, components of the coating are functional molecules and structural molecules and are completely absorbed by a body after playing pharmacological action, and the problem that a traditional stent has inflammation and thrombus risks is fundamentally solved.

The invention belongs to the technical field of biological medicine, and particularly relates to application of valproic acid in preparation of medicine for preventing and / or treating lung fibroblast and lung tissue senescence, the medicine induces the senescent lung fibroblast to excessively accumulate active oxygen in the cell, so that excessive autophagy of the cell is induced, senescent cell apoptosis is caused, and the effect of preventing and / or treating lung fibroblast and lung tissue senescence is achieved. And finally, the lung aging is relieved. The invention provides a new medicine source for preventing, intervening, delaying and researching aging of lung fibroblasts and lung tissues. The medicine for promoting apoptosis of aging cells in vitro or in the lung tissues, provided by the invention, is safe, relatively strong in pharmacological action, small in side effect and definite in curative effect.

The invention discloses a traditional Chinese medicine composition for treating tumors caused by internal stagnation of toxic blood stasis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 47-49 parts of longpimpinella pedicularis, 24-26 parts of black ants and 24-26 parts of toad skin. According to the invention, only the three medicinal materials, namely Longdiland, black ant and toad skin, are adopted, the formula is simple, the medicinal materials are wide in source and controllable in cost, the pharmacological actions of the three medicinal materials are complementary, Longdiland enhances immunity and resists inflammation, black ant regulates immunity, resists inflammation and relieves pain, toad skin directly plays an anti-tumor role, the effects of attacking hard mass, breaking stasis, resisting cancer and diminishing swelling are realized, and a precise formula is prepared aiming at the pathogenesis of internal stagnation of toxic blood stasis; clinical verifications prove that the traditional Chinese medicine can effectively relieve clinical symptoms of tumors caused by internal accumulation of toxic stasis and control recurrence and metastasis of the tumors; meanwhile, the body immunity of patients is improved, the life quality is improved, the survival time is prolonged, and compared with existing partial traditional Chinese medicine preparations, the curative effect is clearer, and the pertinence is higher. The invention further discloses a preparation method of the traditional Chinese medicine composition.

The invention discloses a method for efficiently extracting and purifying radix clematidis volatile oil, and relates to the technical field of radix clematidis extraction.The method includes the steps that raw materials are prepared, and power equipment and raw materials needed by extraction and purification are prepared in advance; the volatile oil in the radix clematidis is extracted by adopting a supercritical CO2 extraction technology, an optimal extraction process of the volatile oil is screened through a single-factor test and an orthogonal test, and the volatile oil is separated and collected, so that compared with a traditional steam distillation method, the extraction effect is more excellent, and a component with relatively high content in the volatile oil of the radix clematidis is linoleic acid; an important reference basis is provided for research on effective components and pharmacological effects of the radix clematidis volatile oil, radix clematidis volatile oil extraction data and corresponding analysis results are managed, visualized and stored, and the intelligent level of radix clematidis volatile oil extraction and purification management is improved.

The application discloses application of a compound in preparation of a medicine for treating androgen alopecia, and relates to the technical field of biological medicines. The foreskin mesenchymal stem cell extracellular small vesicle has water-soluble and fat-soluble double-soluble characteristics, can be absorbed through the skin, and is administered in a manner of intravenous administration / mist administration and the like. The foreskin mesenchymal stem cell extracellular small vesicle is used as a carrier to load curcumin, so that the absorption of the curcumin can be effectively improved, the pharmacological effect of the curcumin can be improved, and the targeting and anti-inflammatory efficiency can be improved. Moreover, the compound obtained by loading the foreskin mesenchymal stem cell extracellular small vesicle with curcumin can easily penetrate into the skin, directly acts on the hair follicles damaged by androgen, has a good effect of treating androgen alopecia, and can significantly promote hair regeneration.

This application relates to the field of pharmaceutical preparations, and discloses a compound preparation composition containing olopatadine and brimonidine for nasal use, and its preparation method. The compound preparation composition for nasal use comprises 0.01-0.5% olopatadine and 0.01-0.5% brimonidine by weight percentage. The compound preparation composition of this invention, with olopatadine and brimonidine used in combination, significantly improves efficacy compared to monotherapy, showing a good synergistic effect, and achieves multiple pharmacological effects with a single dose, greatly improving the convenience of medication and long-term treatment compliance.