49 results about "Pulmonary disease" patented technology

Aspects of the disclosure relate to compositions and methods for base editing using viral vectors. In some aspects, the disclosure provides an adenine base editor (ABE) utilizing an evolved Cas9 nickase derived from Neisseria meningitidis; and adeno-associated viruses (AAVs) comprising (or encoding) such adenine base editors. In some aspects, compositions described herein are useful for treatment of certain diseases, for example pulmonary diseases.

Provided herein are methods for diagnosing and treating a pulmonary disease, e.g., bronchopulmonary dysplasia (BPD) using proteomics analysis.

The application discloses a medical data processing method and product based on multi-stage transfer learning and multi-modal data collaborative fusion, relates to the technical field of medical data processing and artificial intelligence, and adopts MedicalNet medical special pre-training weights to initialize a classification model backbone network; a three-stage progressive fine-tuning framework is constructed on the basis, field adaptive coarse classification fine-tuning and target task fine classification are performed, and clinical structured data is introduced in the third stage; after high-dimensional image features are reduced in dimension and low-dimensional clinical features are increased in dimension through an adaptive multi-branch multi-level MLP architecture, mid-term deep fusion is performed, the application can effectively mine the complex relationships such as complementation, correlation and cooperation of multi-modal heterogeneous data, improve the lung disease classification precision and model generalization capability, and significantly inhibit the small sample overfitting phenomenon.

A deep learning system that detects and counts A-lines in lung images obtained with the VSI protocol, allowing untrained personnel to perform scans. By segmenting and counting A-lines, the system distinguishes between healthy lungs and conditions such as pneumonia or edema, without a specialist intervention. The Attention U-Net architecture improves accuracy, and A-line counting provides quantitative data for diagnostics. This approach aims to expand access to diagnostics, specially in resource-limited areas, offering a scalable solution for early detection of lung disease.

This invention relates to catheter and handle assemblies for tissue treatment. More specifically, the invention relates to a catheter assembly having an elongated shaft, an ablation component coupled to one end of the shaft, and a handle coupled to the other end of the shaft. The handle facilitates axial and circumferential positioning of the ablation component via the shaft in an airway, tubing, or blood vessel for tissue treatment. Embodiments include using the handle during treatment of lung diseases such as COPD and asthma to facilitate axial and circumferential positioning of the shaft and ablation component through and independently of the working channel of a bronchoscope.

To provide a pharmaceutical composition for treating lung inflammation in a mammalian subject having a granulomatous pulmonary disease.SOLUTION: A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a GHRH antagonist.SELECTED DRAWING: None

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating lung diseases and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials: codonopsis pilosula, astragalus membranaceus, white mulberry root-bark, oyster, salvia miltiorrhiza, houttuynia cordata, loofah sponge, angelica sinensis, ligusticum wallichii, peach kernel, lumbricus, radix stephaniae tetrandrae, radix peucedani, radix stemonae, spina gleditsiae, radix curcumae and acanthopanax. Based on the'lung-intestinal axis' theory, by tonifying qi and lung, clearing heat and eliminating phlegm, promoting blood circulation and dredging collaterals, relieving cough and asthma and remodeling intestinal flora of a patient, the level of inflammatory factors is reduced, and the risk of acute exacerbation is reduced. Clinical application shows that the traditional Chinese medicine composition can effectively improve the clinical symptoms of patients, reduce the levels of IL-1beta, IL-6 and TNF-alpha and regulate the intestinal flora structure, and has good treatment potential.

Proposed is a pulmonary disease screening system and a method for screening pulmonary disease using the same, which is configured to integrate a lung function measurement device and a breath analysis device into a single device and analyze biomarkers in pulmonary diseases by extracting the alveolar gas, the last part of the expired air injected into a lung function measurement device.

The invention discloses a data acquisition and analysis system, belongs to the field of data acquisition and analysis, and provides services and assistance for medical staff and government decision makers by fully utilizing various information including treatment schemes, medication data, inspection data, examination data, image data, epidemiological data and the like. And important support is provided for scientific research of novel coronavirus. The invention is constructed according to the characteristics of pneumovirus, has strong specialty, and connects the epidemiological data with the treatment scheme, examination data, examination data, medication data and image data of the patient according to the identification number or the identity card number of the patient in the data acquisition and analysis process. Public health data and hospital internal information system data are fused, and the COVID-19 virus can be comprehensively known.

The utility model discloses a powder collection device of powder coating powder outlet, which aims to solve the technical problem that the existing laboratory sample printing small capacity high speed mixer lacks a dustproof mechanism in the powder collection process of the powder outlet, and the dust of the powder coating may be inhaled by the human body, which may cause respiratory tract irritation or long-term lung disease. The utility model discloses a high speed mixer, a mixing barrel arranged on the top of the high speed mixer, a lower drive motor group fixedly connected to the center of the bottom surface of the mixing barrel, a hinged barrel cover arranged on the edge of the top of the mixing barrel, a discharge channel fixedly arranged on the edge of the bottom surface of the mixing barrel, a manual discharge door fixedly arranged on the inlet of the discharge channel and a receiving barrel. The discharge channel comprises a discharge port. The discharge port is detachably sleeved with a first dustproof cloth and a second dustproof cloth which are through from top to bottom. The first dustproof cloth is located outside the second dustproof cloth. The first dustproof cloth is circumferentially arrayed with a plurality of deformable metal strips along the vertical direction.

The invention relates to a catheter and handle assembly for treating tissue. More specifically, the present invention relates to catheter assemblies having an elongate shaft, an ablation assembly coupled to one end of the shaft, and a handle coupled to the other end of the shaft. The handle facilitates axial and circumferential positioning of the ablation assembly through the shaft in the airway, conduit or vessel for treatment of tissue. Embodiments include the use of a handle to facilitate axial and circumferential positioning of the shaft and ablation assembly through and independent of the working channel of the bronchoscope during the treatment of pulmonary diseases such as COPD and asthma.

Provided are an inhalable pharmaceutical preparation, an apparatus using same, and use thereof in treating pulmonary diseases. The inhalable pharmaceutical preparation comprises a propellant, at least two active pharmaceutical ingredients, a cosolvent, and an anti-aggregation agent, wherein the cosolvent is selected from ethanol and absolute ethanol, and the propellant is tetrafluoropropene.

The present application relates to a method for detecting lung disease by cough sound, which specifically comprises: removing non-cough sound segments from original cough audio to obtain cough audio, and obtaining the start and end time of each single cough segment in the cough audio; generating a logarithmic mel-cepstrum matrix corresponding to each single cough segment according to the start and end time of each single cough segment, and calculating a position encoding matrix corresponding to each single cough segment; obtaining a feature matrix of the cough audio according to the logarithmic mel-cepstrum matrix and the position encoding matrix corresponding to each single cough segment; multiplying the normalized feature matrix of the cough audio by a proportion factor, adding the obtained product to the feature matrix of the cough audio, and inputting the result into a classification network for classification. The present application also relates to a device comprising a cough sound detection unit, an audio signal processing unit, a splicing unit, a normalization unit and a classification network unit. The method and device of the present application can improve the accuracy of the detection result.

The present invention provides compounds for use in the treatment of pulmonary diseases, particularly asthma, wherein the compounds bind to the cytokines IL-13 and TSLP. The treatment according to the invention is capable of reducing the level of exhaled nitric oxide (FeNO) by at least 18 ppb compared to placebo. The treatments of the invention are also capable of reducing eosinophil count, increasing FEV1 and / or reducing airway inflammation.

Provided herein are compositions and methods for treating and preventing pulmonary diseases. In particular, provided herein are surfactant protein A (SP-A) peptide analogs (e.g., SP-A peptidomimetics) and their use in treating and preventing pulmonary diseases (e.g., asthma or COPD).

The invention provides methods and compositions relating to identification and use of genetic information from the FOXO3A gene that can be used for determining and increasing an individual's likelihood of longevity and of retaining physical and cognitive function during aging, and for determining and decreasing an individual's likelihood of developing a cardiovascular-, metabolic- or age-related disease, including coronary artery (heart) disease, stroke, cancer, chronic pulmonary disease, diabetes, Parkinson's disease and dementia.

The compound 1,1-dioxido-2,3-dihydrothiophen-3-yl 4-phenoxybenzenesulfonate, pharmaceutical compositions thereof, and use of the compound and the pharmaceutical compositions for treating cancer and pulmonary diseases are disclosed.

Pharmaceutical compositions comprising imatinib or a derivative thereof for treatment of a pulmonary disease via inhalation. Methods of treating a pulmonary disease include administering by inhalation an effective amount of imatinib or a derivative thereof to a patient in need thereof. In aspects, the pharmaceutical composition provided herein comprises an aqueous solution or suspension of imatinib or a derivative thereof that is formulated for inhalational administration.

The application discloses a medical data processing method and product based on multi-stage transfer learning and multi-modal data collaborative fusion, relates to the technical field of medical data processing and artificial intelligence, and adopts MedicalNet medical special pre-training weights to initialize a classification model backbone network; a three-stage progressive fine-tuning framework is constructed on the basis, field adaptive coarse classification fine-tuning and target task fine classification are performed, and clinical structured data is introduced in the third stage; after high-dimensional image features are reduced in dimension and low-dimensional clinical features are increased in dimension through an adaptive multi-branch multi-level MLP architecture, mid-term deep fusion is performed, the application can effectively mine the complex relationships such as complementation, correlation and cooperation of multi-modal heterogeneous data, improve the lung disease classification precision and model generalization capability, and significantly inhibit the small sample overfitting phenomenon.

DEEP LEARNING-BASED DEVICE FOR EARLY LUNG DISEASE DETECTION

The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating pulmonary diseases and a preparation method and application thereof.The traditional Chinese medicine composition comprises the following raw materials: radix codonopsis, radix astragali, cortex mori, oyster, radix salviae miltiorrhizae, hedyotis diffusae, luffa, angelica sinensis, ligusticum wallichii, persicae semen, earthworm, radix stephaniae tetrandrae, radix peucedani, radices baphlai, kadsurae caudice, radix notoginseng and acanthopanax.The present application is based on the theory of lung-intestine axis, and can improve the clinical symptoms of patients, reduce the levels of IL-1beta, IL-6 and TNF-alpha, regulate the structure of intestinal flora, and has good treatment potential by tonifying qi and tonifying lung, clearing heat and reducing phlegm, promoting blood circulation and dredging collaterals, relieving cough and asthma, and remodeling intestinal flora of patients.

A positive expiratory pressure-generating device for reducing breathlessness in a subject with one or more pulmonary disorders is disclosed. The device is rigid and hollow and can be held in the mouth of the subject. The device has at least one air chamber, at least one opening in the portion of the device that is held in the mouth and at least one additional airflow orifice. The device is configured to increase expiratory resistance and can be supported by the mouth of the subject without the need for additional support by hands, another device or other means.

The utility model relates to the technical field of cooling fans, in particular to an active oxygen water spray cooling fan which comprises a shell with an opening in the side face and a water spray outlet fixedly installed at the opening and further comprises a water spray pipeline connected with an inlet of the water spray outlet, and the water spray pipeline comprises a water pump, a water flow pipeline, a BDD active oxygen generator, an atomization device and a spray head which are sequentially connected. A light plasma generator is arranged between the nozzle outlet and the water mist outlet, and the light plasma generation direction of the light plasma generator is aligned with the outlet of the water mist outlet. According to the active oxygen water spray cooling fan, the bdd active oxygen generator is arranged in the water conveying pipeline, used for generating water mist, of a conventional cooling fan, water is prepared into active oxygen water in the pipeline, then the active oxygen water is sent to the atomization spray head to be sprayed out, biological pollution in water is reduced through the water mist formed through active oxygen water sterilization, and the water mist is sprayed out. Lung diseases caused by the fact that workers in a service area inhale untreated water mist are reduced.

This invention discloses a medicinal and edible homologous composition and its application in the preparation of drugs or foods for improving chronic lung diseases, belonging to the field of pharmaceutical technology. The medicinal and edible homologous composition of this invention uses donkey-hide gelatin and astragalus as the principal ingredient, apricot kernel and burdock seed as the assistant ingredient, loquat leaf as the adjuvant ingredient, and platycodon and licorice as the auxiliary and guiding ingredients. Through the use of volatile oil extraction and re-addition techniques, as well as the separate "melting" of donkey-hide gelatin, the heat-sensitive volatile oil components in the raw medicinal materials are preserved, and a networked regulatory mode of "synthesis promotion-degradation inhibition-signal enhancement" is constructed, achieving deep activation of the cAMP pathway. The medicinal and edible homologous composition has pharmacological activities that improve lung function and inhibit airway inflammation. The activity is significantly superior to that of donkey-hide gelatin, roflumilast, and hormones used alone; the medicinal and edible homologous composition exhibits excellent synergistic effects in the treatment of COPD and asthma, and has improving and therapeutic effects on chronic lung diseases induced by inflammation, bronchoconstriction, and mucus secretion, and can delay the progression of COPD and asthma, providing a new approach and direction for the preparation of drugs or foods that improve chronic lung diseases; this invention can provide core technical support for the secondary development of traditional Chinese medicine compound prescriptions and the creation of new drugs, thereby effectively promoting the modernization of traditional Chinese medicine.

Endobrochial implants and delivery systems therefor are disclosed herein. In some embodiments, a delivery system can be used for deploying an implant at a treatment location, where the implant includes a tubular region with one or more interstitial regions. A delivery system can, for example include a flexible elongate member having an implant mounting surface, wherein the implant mounting surface comprises a conformable material configured to adapt to the one or more interstitial regions of the implant when the implant is radially collapsed on the implant mounting surface, thereby engaging the implant. The delivery system can also include a sheath at least partially covering the elongate member, wherein the sheath is movable relative to the elongate member to at least partially expose the implant mounting surface.