1517 results about "Spleen" patented technology

The invention discloses bifidobacterium animalis and application thereof in allergic rhinitis products, and belongs to the technical field of microorganisms. The technical problem to be solved is that the existing common allergic rhinitis treatment means cannot meet the requirements of patients on safety, long-acting effect and treatment cycle. The invention provides an animal bifidobacterium subsp. Lactis Def +, and after an effective dose of animal bifidobacterium subsp. Lactis Def + is applied to a subject, the animal bifidobacterium subsp. Lactis Def + is found to be capable of remarkably relieving the allergic rhinitis symptom. Specifically, the symptoms of sneezing, dry nose and rhinocnesmus are reduced; the number of nasal septum mucosa intrinsic layer inflammation infiltration cells and nasal septum mucosa epithelium pathological changes are reduced; the IgA and IgE levels of serum are reduced; the levels of proinflammatory factors IL-4, IL-5 and IL-13 are reduced; the normal spleen index is maintained; the imbalance state of Th1 / Th2 and Th17 / Treg is effectively improved, and the body immunity is improved; a safe and long-acting scheme is provided for allergic rhinitis diseases.

The invention discloses a traditional Chinese medicine diagnosis and treatment aided decision-making method and system, and relates to the technical field of traditional Chinese medicine intelligent diagnosis and treatment aided decision-making, and the method comprises the steps: carrying out the wavelet transformation analysis of pulse condition waveform time series data, extracting a pulse condition dynamic change feature sequence, inputting a tongue image color change rate and a pulse condition feature change rate into a space-time convolution network, and obtaining a time-space convolution network; generating a tongue pulse dynamic association index and outputting a preliminary syndrome classification; fourier transform analysis is carried out on the spleen channel acupoint impedance spectrum, false-true state judgment is carried out in combination with tongue pulse dynamic correlation indexes, preliminary syndrome classification is corrected, and a false-true state quantification result and corrected syndrome classification are output; and matching the corrected syndrome classification with the traditional Chinese medicine knowledge map, adjusting the dosage according to a virtual-real state quantification result, reversely verifying the drug-syndrome specificity through a curative effect database, screening an optimal treatment scheme, and outputting a personalized diagnosis and treatment scheme. According to the method, the syndrome classification precision is improved, and an objective basis is provided for personalized dose adjustment.

The invention provides a traditional Chinese medicine composition for treating or improving asthma, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: inula flower, tabasheer, Japanese ardisia herb, cymbopogon distans, ligusticum, pyrrosia lingua, pawpaw, yam rhizome, rhizoma atractylodis, walnut meat, maltose, citron and liquorice. The monarch, minister, assistant and guide in the traditional Chinese medicine composition make the best responsibility, the traditional Chinese medicine composition aims at the symptoms of phlegm-qi obstruction and adverse rising of lung qi of asthma, also has the effects of strengthening the spleen, tonifying the kidney, soothing the liver and the like to consolidate the root cause, has the effects of dispelling wind and ventilating the lung, eliminating phlegm and lowering adverse qi, tonifying the spleen and eliminating dampness, warming the kidney and absorbing qi, and regulating the liver and regulating qi, and has the effects of purgation and tonification and treatment of both symptoms and root causes. The traditional Chinese medicine composition can effectively inhibit airway inflammation reaction of asthma model mice and improve clinical symptoms of the asthma mice, and is remarkable in treatment effect. The traditional Chinese medicine composition disclosed by the invention has a relatively high total effective rate for treating asthma, and has more advantages in the aspects of relieving clinical symptoms of asthma patients and improving lung functions.

A method for performing classification of a severity of at least one liver disease from non-invasive radiographic images is disclosed. The method comprises: providing radiographic images of slices of an abdomen of a patient; pre-processing said radiographic images by: segmenting a liver and a spleen, thus achieving a spleen binary mask and a liver binary mask per slice, and normalizing said images with each other, thus achieving normalized radiographic images per slice; for each slice, from the liver binary mask and said normalized radiographic images, extracting a liver parameter; from at least one spleen binary mask, extracting a spleen parameter; and classifying, in function of both parameters and by help of a trained Machine Learning model, the severity of the at least one liver disease between one among a group of liver disease at early stage and a group of liver disease at advanced stage.

The invention discloses a postoperative portal vein pressure prediction system, which relates to the technical field of portal vein pressure prediction, and is characterized in that three-dimensional structure regions of interest of the liver and the spleen are segmented based on preoperative and postoperative abdomen enhanced CT vein phase image data of a patient; image omics features including first-order statistical features, texture features and shape features are extracted from the segmented regions of interest of the three-dimensional structures of the liver and the spleen, and core feature screening is carried out on the extracted features; integrating the screened core features with clinical hemodynamic parameters and surgical parameters to construct a multi-modal prediction model of the portal vein pressure gradient; and predicting and outputting a portal vein pressure gradient predicted value by using the multi-modal prediction model of the portal vein pressure gradient, and determining a postoperative portal vein pressure gradient risk grade of the patient. The portal vein pressure gradient prediction method solves the problems of insufficient dynamic evaluation capability, multi-modal information integration and risk layering application in the prior art, and realizes non-invasive and accurate prediction of the portal vein pressure gradient.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating liver depression and spleen deficiency syndrome metabolism-related fatty liver disease, which is prepared from the following raw materials in parts by weight: 8 to 10 parts of ginseng, 10 to 15 parts of radix bupleuri, 10 to 15 parts of radix curcumae, 6 to 9 parts of ginger processed pinellia, 6 to 10 parts of fructus amomi, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of semen hoveniae, 10 to 15 parts of radix rehmanniae, 8 to 10 parts of rhizoma polygoni cuspidati and 6 to 9 parts of lignum dalbergiae odoriferae. The traditional Chinese medicine composition is used for treating the metabolism-related fatty liver diseases from the aspects of liver depression, spleen deficiency and phlegm-blood stasis, starts from the core pathological chain of liver depression, spleen deficiency, phlegm-dampness and blood stasis, has the functions of soothing the liver, tonifying the spleen, resolving dampness, reducing fat and promoting blood circulation to remove meridian obstruction, and is particularly suitable for patients with liver depression, spleen deficiency and metabolism-related fatty liver diseases. Clinical tests prove that the traditional Chinese medicine composition has a good treatment effect on patients with liver depression and spleen deficiency syndrome metabolism-related fatty liver diseases, the total effective rate reaches 94% or above, and the traditional Chinese medicine composition is mild in medicine property, good in safety, stable in curative effect, not prone to relapse and suitable for being taken for a long time.

The invention discloses a preparation method of deer spleen aminopeptide powder in the field of bioactive substance extraction and functional material compositing, and the performance of the deer spleen aminopeptide powder is improved by compositing a multi-stage functional modified material and deer spleen aminopeptide. The preparation method comprises the following steps: cleaning, homogenizing and crushing fresh deer spleen, extracting with a phosphate buffer solution, adjusting the pH value, carrying out enzymolysis, inactivating enzyme, and treating with an ultrafiltration membrane and a nanofiltration membrane in a specific molecular weight range to obtain a concentrated solution; and mixing the concentrated solution with a multi-stage functional modified material under proper conditions, sterilizing, pre-freezing, and freeze-drying to obtain the deer spleen aminopeptide powder. Wherein the modified material is constructed through quaternization modification, nanopore loading, enzyme inhibitor coupling and targeting ligand modification, and has the functions of charge repulsion, steric hindrance, enzyme inhibition and targeting recognition. The deer spleen aminopeptide powder prepared by the invention has high stability and good bioavailability, and is suitable for functional food or health care products.

The invention discloses a highly inert Gd-DOTA-based contrast agent with a hydrophobic side chain as well as a preparation method and application of the highly inert Gd-DOTA-based contrast agent, and two novel Gd-DOTA-based contrast agents Gd-L1 and Gd-L2 are successfully developed by respectively connecting hydrophobic 3-phenyl propylamine and 3, 3-diphenyl propylamine to Gd-DOTABA. The two novel Gd-DOTA-based contrast agents remarkably improve the chemical inertness of the complex, the dissociation half-life period of the complex in a 1 M HCl solution at 37 DEG C is about 5 times that of Gd-DOTA, and a powerful guarantee is provided for clinical safety; the MRI (Magnetic Resonance Imaging) performance of the liver in a mouse shows that Gd-L1 is equivalent to commercially available Gd-BOPTA and is suitable for imaging of a liver and gall system; after the Gd-L2 is combined with the human serum albumin, the longitudinal relaxation rate is obviously increased (r1 = 14.8 mM <-1 > s <-1 >, 1.4 T, 37 DEG C), the blood elimination half-life period in a rabbit model is about 18 minutes, and the Gd-L2 is suitable for vascular MRI (Magnetic Resonance Imaging). The two contrast agents avoid the spleen residual problem, the organ accumulation possibility is reduced, and a safer and more efficient MRI diagnostic tool is provided for clinic.

The invention provides a compound or an N-oxide, a solvate, a pharmaceutically acceptable salt or a stereoisomer thereof, and also provides a composition containing the compound and application of the compound and the composition to delivery of a therapeutic agent or a prophylactic agent. According to the invention, the types of cationic lipid compounds are enriched, and more choices are provided for effective delivery of nucleic acid drugs, gene vaccines, small molecule drugs, polypeptides or protein drugs. After the lipid nanoparticles are formed with other lipid components, mRNA or drug molecules can be effectively delivered into cells to exert biological functions.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating meniere disease membrane hydrolost and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: rhizoma alismatis, rhizoma atractylodis macrocephalae, poria cocos, gastrodia elata, ginger processed pinellia, pericarpium citri reticulatae and fresh ginger. The traditional Chinese medicine composition disclosed by the invention is small in dosage and special in effect, and dialectical compatibility is performed according to the phlegm-dampness theory of traditional Chinese medicine, combined with the pathological basis of the meniere disease and based on the treatment rules of transforming fluid retention, inducing diuresis, tonifying spleen and calming liver, so that the aim of treating both symptoms and root causes is achieved. Animal experiments prove that the traditional Chinese medicine composition can obviously relieve the cochlear hydrops degree of a rat with membranous hydrolost.

The invention provides a spleen peptide for promoting growth and tonifying spleen as well as a preparation method and application thereof, and belongs to the technical field of biochemistry. The invention provides a preparation method of spleen peptide capable of promoting growth and tonifying spleen. The preparation method comprises the following steps: degreasing spleen particles of healthy animals, fermenting after degreasing, performing subcritical water extraction, performing protease enzymolysis, fermenting an enzymolysis product, clarifying fermentation liquor, and then performing filtration, nanofiltration and spray drying treatment. According to the preparation method, the preparation process of the spleen peptide is reasonably set, so that the prepared spleen peptide is high in protein content, low in average molecular weight, easy to absorb and utilize, free of fat detection, capable of tonifying the spleen and promoting growth, capable of being dissolved into water to form transparent liquid, capable of being processed into tablets, powder and oral liquid, also capable of being used in common food, high in yield and suitable for popularization and application. The method is suitable for industrial popularization.

The invention relates to a composition for treating large yellow croaker pyramidoniasis as well as a preparation method and application thereof, and belongs to the technical field of aquaculture. The composition comprises the following components: curcumin, bile acid, beta glucan, bacillus subtilis freeze-dried powder, marine red yeast freeze-dried powder, vitamin C, vitamin E and ethylicin. When the feed additive is added into basal feed to feed large yellow croakers infected with the trypanosomiasis, the death rate of sick fishes can be effectively reduced, the polypide loading capacity is remarkably reduced, and pathological injuries of livers and spleens of the large yellow croakers are relieved. In addition, the composition can also improve the non-specific immunity of the fish body, improve the liver function, enhance the antioxidant capacity of the liver, and improve the lipase activity of the intestinal tract at the same time. Therefore, the composition can be used as a medicine or a feed additive for treating the large yellow croaker pyramidoniasis, has the advantages of small dosage and remarkable effect, and provides a new technical approach for solving the problem that the current large yellow croaker pyramidoniasis lacks an effective prevention and control means.

The invention provides an interactive recognition measurement method and device based on an AI non-enhanced CT image, and relates to the technical field of medical image processing. The method comprises the following steps: establishing an image task queue based on a batch liver and spleen CT image set; inputting each liver and spleen CT image in the batch liver and spleen CT image set into a pre-trained organization structure recognition model in sequence according to the first task queue, and determining a segmentation mask corresponding to a target organization structure region; interaction data is received to generate a calibration mask, the model is optimized by combining the segmentation mask and the calibration mask, and the optimized model is used for processing the remaining liver and spleen CT images in the second task queue until recognition of all the liver and spleen CT images is completed; and determining a CT value measurement result of each liver and spleen CT image through a pixel gray value in the mask region. According to the scheme, the tissue structure recognition precision and the CT value measurement stability and accuracy of batch liver and spleen CT images during recognition and measurement can be improved.

The invention belongs to the technical field of microbial fermentation, and particularly relates to a lactobacillus rhamnosus fermentation composition, a preparation method and application of the lactobacillus rhamnosus fermentation composition in the aspects of improving the tumor cell induced inflammation level and preventing and inhibiting breast tumors. The invention provides a lactobacillus rhamnosus fermentation composition. The lactobacillus rhamnosus fermentation composition is prepared from a raw material and lactobacillus rhamnosus NKU ML1-2, the raw materials comprise raspberry, poria cocos, cape jasmine, rehmannia, liquorice and orange peel. The lactobacillus rhamnosus fermentation composition has the effects of nourishing yin and clearing heat, soothing liver and regulating qi, and strengthening spleen and stomach. Results of embodiments show that the lactobacillus rhamnosus fermentation composition can prevent proliferation, invasion and migration of breast cancer tumor cells to a certain extent, and has an improvement effect on the level of inflammation induced by the tumor cells.

The invention discloses a hematopoietic preparation for treating androgenetic alopecia and a preparation method of the hematopoietic preparation. The hematopoietic preparation is prepared from 5-30 parts of radix polygoni multiflori preparata, 5-30 parts of wine ligustrum lucidum ait, 5-30 parts of mulberry, 5-30 parts of eclipta, 5-30 parts of radix paeoniae alba, 5-30 parts of astragalus membranaceus and 5-30 parts of rhizoma cibotii. The medicine composition and the specific dosage are obtained through a large number of experimental screening and clinical medication experience screening. The whole formula takes tonifying liver and kidney and benefiting essence and blood as the monarch, and takes tonifying spleen and qi and removing heat to cool blood as the minister and assistant, based on the traditional Chinese medicine theory that essence is stored in kidney and is warmed on hair, by inhibiting DHT generation, resisting hair follicle apoptosis and improving scalp microcirculation, the traditional Chinese medicine composition has the remarkable effect of treating androgenetic alopecia, is weak in toxic and side effects, and can be prepared into various clinical dosage forms.

The invention provides a pharmaceutical composition for treating simple obesity as well as a preparation method and application thereof, and belongs to the field of medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-20 parts of astragalus membranaceus, 5-10 parts of radix stephaniae tetrandrae, 6-12 parts of bighead atractylodes rhizome, 10-15 parts of poria cocos, 6-10 parts of rhizoma alismatis, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of cassia twig, 15-20 parts of semen coicis, 5-10 parts of pericarpium arecae, 5-10 parts of mangnolia officinalis, 5-10 parts of fructus aurantii, 3-10 parts of lotus leaves, 10-15 parts of semen cassiae, 10-15 parts of salvia miltiorrhiza, 5-12 parts of hawthorn and 5-10 parts of liquorice. Research results prove that the pharmaceutical composition disclosed by the invention is precise and appropriate in formula, can effectively reduce body weight and body fat, provides a new choice for clinically treating simple obesity caused by spleen deficiency and excessive dampness, and has a good application prospect.

The invention relates to a recombinant complement protein and application thereof in preparation of anti-leukemia drugs, and belongs to the technical field of biological medicines. The invention discloses a method for treating acute leukemia by single drug, namely injecting recombinant C1QBP protein, which has a remarkable effect on treating acute leukemia, can be used for remarkably inhibiting proliferation of leukemia cells in marrow, spleen and peripheral blood of a hematopoietic system and also inhibiting infiltration of the leukemia cells in extramedullary organs (skin and the like), so that the whole-body tumor load is reduced, and the curative effect of treating acute leukemia is improved. The lifetime of leukemia mice is obviously prolonged. The recombinant C1QBP protein is combined with a clinical first-line chemotherapy regimen for use, has a synergistic effect, has a stronger effect of inhibiting leukemia cell proliferation compared with a single chemotherapy drug, can significantly prolong the lifetime of leukemia mice, and plays a role in reducing toxicity and enhancing efficacy. The invention proves that the complement C1Q binding protein has the effect of treating leukemia for the first time, provides a preparation method and a drug combination scheme, and has relatively high clinical transformation prospect and application value.

The present invention relates to a novel lipid compound for tissue-specific delivery, and a lipid nano-particle (LNP) composition comprising the same, the lipid nano-particle comprising a modified lipid compound as a component, according to the present invention, internal active substances are selectively delivered into cells of specific tissues such as lymph nodes, spleen, retina, cancer, brain, liver and the like in vivo, thereby preventing side effects and safely exhibiting a desired level of effect. The tissue-specific non-viral LNP delivery vectors can be effectively used for prevention of infectious diseases and treatment of rare and refractory (hereditary) diseases (diseases which are effectively and selectively delivered to in-vivo targeted sites, such as macular degeneration, diabetic retinal degeneration, hereditary retinal degeneration, cancer, cerebral diseases, liver diseases and the like).

The invention provides a preparation method of a Witzia ciliaris IOB502 microbial inoculum and an application of the Witzia ciliaris IOB502 microbial inoculum in the aspect of recovering intestinal motility, the Witzia ciliaris IOB502 microbial inoculum is prepared by adopting a method of carrying out low-oxygen stress staged fermentation on chickpeas by adopting the Witzia ciliaris IOB502, and the generation of vitamins B1 and B2 can be promoted. The microbial inoculum does not affect physiological development of important organs such as liver, spleen and small intestine of mice, can improve defecation symptoms of the mice with constipation, increase defecation times and water content of excrement, improve intestinal movement of the mice with constipation, promote smooth passage of intestinal contents, effectively improve colon injury of the mice with constipation, and improve the constipation rate of the mice with constipation. Comprising mucous membrane layer thinning and mucus secretion reduction.

The invention relates to the technical field of disease animal models, in particular to a construction method, an evaluation method and application of a bipolar affective disorder liver stagnation and spleen deficiency syndrome combined animal model. According to the method, a liver depression and spleen deficiency syndrome modeling method is adopted for model construction, evaluation indexes are formulated by combining manic and depression behavior expressions of mice and innovatively combining typical expressions of liver depression and spleen deficiency, a liver depression and spleen deficiency syndrome animal model evaluation method is explored, and a thought is provided for achieving standardization and normalization of liver depression and spleen deficiency syndrome model evaluation. The modeling method is simple and economical, provides an experimental animal model for syndrome differentiation treatment of diseases, particularly provides a corresponding animal model for traditional Chinese medicine syndrome differentiation treatment and new drug pharmacological experiments, accelerates the progress of traditional Chinese medicine disease syndrome research and new drug development, provides technical service for drug evaluation, and has great application value.

The invention provides a traditional Chinese medicine composition for treating ovarian reserve function decline. The traditional Chinese medicine composition is prepared from the following medicines in parts by mass: 9-30 parts of radix astragali preparata, 6-20 parts of roasted rhizoma atractylodis macrocephalae, 10-15 parts of poria cocos, 2-10 parts of radix glycyrrhizae preparata, 6-20 parts of semen cuscutae, 9-20 parts of radix dipsaci (dipsacus root), 6-12 parts of herba lycopi and 6-15 parts of lily. Experimental results show that the traditional Chinese medicine composition is suitable for improving the ovarian function of a patient suffering from spleen-kidney deficiency type ovarian reserve function decline.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for improving obesity and metabolic syndrome and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 28 parts of radix astragali seu hedysari, 8 to 20 parts of radix codonopsis, 20 to 35 parts of rhizoma dioscoreae, 8 to 24 parts of semen lablab album, 6 to 20 parts of rhizoma atractylodis macrocephalae stir-fried with bran, 20 to 35 parts of raw semen coicis, 3 to 10 parts of rhizoma pinelliae preparata, 6 to 15 parts of pericarpium citri reticulatae, 10 to 20 parts of poria cocos, 6 to 15 parts of rhizoma alismatis, 6 to 15 parts of raw liquorice root, 10 to 20 parts of semen hoveniae, 10 to 20 parts of lotus leaf and 8 to 15 parts of raw fructus crataegi. The composition has the effects of invigorating spleen, replenishing qi, resolving dampness and removing turbidity, can effectively control the weight gain of obese patients and improve the metabolic disorder condition of metabolic syndrome, is safe, effective and stable, has small side effects, and has very good research and development values.

The present application relates to a kind of traditional Chinese medicine composition for treating cervical spondylosis and its preparation method and use, belong to the field of traditional Chinese medicine.The traditional Chinese medicine composition of the present application is prepared from the following weight ratio of raw medicinal materials: Huangqi 14.4-21.6 parts, Baishao 14.4-21.6 parts, Jixueteng 14.4-21.6 parts, Gegen 14.4-21.6 parts, Sangzhi 14.4-21.6 parts, Gouqi 7.2-10.8 parts, Tianma 7.2-10.8 parts, Chuanqiong 7.2-10.8 parts, Lingshenteng 7.2-10.8 parts, Zexie 7.2-10.8 parts, Baizhu 7.2-10.8 parts, Sanqi 2.4-3.6 parts.The present application also provides the preparation method and use of the traditional Chinese medicine composition.The present application is aimed at the complex syndrome type of "deficiency of liver and kidney combined with phlegm-dampness blocking meridians cervical spondylosis", introduces Zexie and Baizhu drug pair, and combines water and removes dampness, and has the effect of invigorating spleen and drying dampness, is specially used for treating phlegm-dampness dizziness, and the compatibility of "Tianma" significantly enhances the ability of resolving phlegm, calming wind and stopping dizziness.At the same time, Chuanqiong is introduced to promote blood circulation and qi, and goes up to head and eyes to stop pain, and Jixueteng, Lingshenteng and Gegen form synergistic compatibility, the medicinal property is mild, the curative effect is remarkable, the side effect risk is low, and it is suitable for long-term nursing of cervical spondylosis.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method and application thereof. According to the technical scheme, the traditional Chinese medicine composition is characterized by being prepared from, by weight, 10-50 parts of radix codonopsis, 5-20 parts of roasted rhizoma atractylodis macrocephalae, 5-10 parts of rhizoma pinellinae praeparata, 2-8 parts of rhizoma coptidis, 8-40 parts of poria cocos, 5-15 parts of radix salviae miltiorrhizae, 3-6 parts of rhizoma zingiberis, 5-15 parts of rhizoma cyperi, 1-20 parts of radix actinidiae chinensis and 1-5 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition provided by the invention can improve the pathological morphology of stomach tissues, increase the expression of PG I and the ratio of PG I to PG II, reduce the level of inflammatory factors and improve the atrophy degree of gastric mucosa, and is used for treating stomachache, distention and fullness, anorexia, gastric noisy and other symptoms caused by spleen and stomach qi deficiency, qi stagnation and blood stasis and damp-toxin interjunction of patients with chronic atrophic gastritis.

Disclosed in the present invention are a targeted immunotolerance vaccine, a preparation method therefor, and use thereof. The present invention separately modifies a rheumatoid arthritis-related autoantigen peptide and CTLA4 Ig with DSPE-PEG (DP) to prepare a targeted formulation DP-antigen peptide and a targeted formulation DP-CTLA4, which are then mixed to obtain the vaccine. The vaccine described in the present invention, after intravenous injection, binds to albumin in vivo by means of DSPE, "hitchhiking" on albumin to target and enrich in inflammatory lesions, the spleen, the liver, and other tolerance-inducing sites, inhibiting T cell activation, and inducing anergy and apoptosis of rheumatoid arthritis autoantigen-specific T cells, thereby achieving immunotolerance treatment and prevention of rheumatoid arthritis.

The invention relates to a traditional Chinese medicine composition for treating cervical spondylosis and a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 14.4 to 21.6 parts of radix astragali seu hedysari, 14.4 to 21.6 parts of radix paeoniae alba, 14.4 to 21.6 parts of caulis spatholobi, 14.4 to 21.6 parts of radix puerariae, 14.4 to 21.6 parts of ramulus mori, 7.2 to 10.8 parts of fructus lycii, 7.2 to 10.8 parts of rhizoma gastrodiae, 7.2 to 10.8 parts of rhizoma chuanxiong, 7.2 to 10.8 parts of radix clematidis, 7.2 to 10.8 parts of rhizoma alismatis, 7.2 to 10.8 parts of rhizoma atractylodis macrocephalae and 2.4 to 3.6 parts of radix notoginseng. The invention further provides a preparation method and application of the traditional Chinese medicine composition. Aiming at a compound syndrome type of liver and kidney deficiency combined with phlegm-damp collateral blocking cervical spondylosis, the rhizoma alismatis and bighead atractylodes rhizome pairs are introduced to achieve the effects of clearing damp, promoting diuresis, tonifying spleen and drying dampness together, and the traditional Chinese medicine is specially used for treating phlegm-damp dizziness and is matched with the rhizoma gastrodiae, so that the effects of reducing phlegm, stopping wind and stopping dizziness are remarkably enhanced. Meanwhile, ligusticum wallichii capable of promoting blood circulation and qi circulation is introduced to move upwards to relieve pain and forms synergistic compatibility with caulis spatholobi, herba clematidis and radix puerariae, and the traditional Chinese medicine composition is mild in medicine property, remarkable in curative effect, low in side effect risk and suitable for long-term nursing of cervical spondylosis.

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis. The composition is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 15-25 parts of gentian, 20-30 parts of selfheal, 18-22 parts of chrysanthemum, 20-30 parts of mint, 15-25 parts of scutellaria, 12-16 parts of gardenia, 15-25 parts of peony bark, etc. The composition can clear liver fire, clear stomach fire, soothe the liver and harmonize the stomach, promote blood circulation and soften the liver, strengthen the spleen and replenish qi, and reduce stomach qi and lung qi, thereby jointly treating reflux esophagitis of liver and stomach stagnation heat type with significant effect. The invention also discloses a preparation method thereof.

The invention provides a traditional Chinese medicine composition and application thereof in preparation of anti-fatigue health care wine, and relates to the technical field of traditional Chinese medicine preparation and traditional Chinese medicine health care. The traditional Chinese medicine composition takes medicinal and edible traditional Chinese medicinal materials as raw materials, is prepared from herba cistanche, radix acanthopanacis semticosi, radix asparagi, fructus phyllanthi, pollen typhae, fructus canarii, herba cichorii, folium microcotis, semen canavaliae and fructus citri, and has the effects of tonifying kidney and spleen, tonifying qi and yin and combining clearing and tonifying. The traditional Chinese medicine composition and the health-care wine prepared from the traditional Chinese medicine composition provided by the invention have an excellent anti-fatigue effect, and can be used for remarkably prolonging the weight-bearing exhaustion swimming time of mice, remarkably reducing the plasma urea nitrogen content of the mice after exercise, remarkably improving the hepatic glycogen content of the mice and remarkably improving the blood lactic acid clearance of the mice after exercise; the obvious physical fatigue relieving effect is realized. The compound is expected to be developed into anti-fatigue medicines or health-care products.

The invention belongs to the field of traditional Chinese medicine preparations, and provides a pure traditional Chinese medicine preparation for treating depression and a preparation method of the pure traditional Chinese medicine preparation. The preparation method comprises the following steps: S1, weighing raw materials according to a formula, putting the raw materials into a clean container, adding water which is 8-12 times of the total weight of the raw materials, and soaking at room temperature for 1-2 hours; s2, transferring the soaked raw materials and liquid medicine into a decoction container, boiling with strong fire, then turning into slow fire, and decocting for 1.5-2.5 hours in a slightly boiling state; according to the pure traditional Chinese medicine preparation disclosed by the invention, through reasonable compatibility of various traditional Chinese medicinal materials, all the components have a synergistic effect, and the effects of soothing liver and regulating qi, strengthening spleen and harmonizing stomach, nourishing heart and tranquilizing mind, promoting blood circulation to remove blood stasis, reducing phlegm and clearing damp are jointly achieved; the pure traditional Chinese medicine preparation can effectively improve the symptoms of low mood, restless mood, insomnia and dreaminess, inappetence and hypodynamia of depression patients, and clinical practice verifies that the pure traditional Chinese medicine preparation prepared by the invention has a remarkable effect in the aspect of treating depression compared with existing conventional anti-depression western medicines.

The invention belongs to the technical field of cellular immunity, and particularly relates to calcium-doped manganese phosphate engineered red blood cells based on a biomimetic mineralization technology and application of the calcium-doped manganese phosphate engineered red blood cells in immunotherapy. Calcium ions, manganese phosphate, acidic polypeptide and a carboxyl activator are deposited on the surfaces of red blood cells, the acidic polypeptide provides a negative electricity environment, the concentration of calcium and manganese on red blood cell membranes is increased, and a mineralization layer of calcium ions and manganese ions is formed; the carboxyl activator can activate carboxyl of amino acid on acidic polypeptide and is covalently bound with other molecules; calcium can improve the stability of the manganese phosphate crystal, optimize the release of manganese ions and activate a cGAS-STING pathway in the DC; the natural half-life period of red blood cells reaches 120 days, rapid clearing of the liver can be avoided, the aged red blood cells are swallowed by spleen DC, and cross presentation of antigens is promoted. The calcium-doped manganese phosphate engineered erythrocyte provided by the invention can promote the maturation, migration, homing and antigen presentation functions of dendritic cells, and enhance the ability of the dendritic cells to activate CD8 + T cells.