The invention discloses a cloud platform system and method oriented to biological omics big data calculation, and relates to the technical field of maintenance or management devices. The system comprises a system management module, a data management module, an application management module, a process management module, a task management module, a data visualized operation module and a user and authority management module. The cloud platform system is seamlessly connected with a high-performance calculation cluster system through a distributed type calculation and management mode of the high-performance calculation cluster system, the WEB technology and the computer remote calling, remote controlling and cloud calculating and other technological means, the management and utilization of big data are achieved, and the deep mining, analysis and utilization of biological omics big data by means of online, visual and free customization processes and tools are achieved. By means of the system, the application of the high-performance calculation cluster system in the field of biological omics big data can be promoted, and the deep mining, analysis and industrial application of biological omics big data can also be promoted.