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247 results about "Inducible gene" patented technology
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Inducible genes - The operon model. Definition. An inducible gene is a gene that is expressed in the presence of a substance (an inducer) in the environment. This substance can control the expression of one or more genes (structural genes) involved in the metabolism of that substance.
Novel substitution mutant receptors and their use in an nuclear receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
InactiveUS20050266457A1Improve efficiencyGreat degree of sequence similarityBiocideBacteriaHigh-Throughput Screening AssaysGenomics
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Novel ecdysone receptor-based induicible gene expression system
InactiveUS20070161086A1Fusion with DNA-binding domainAntibody mimetics/scaffoldsHigh-Throughput Screening AssaysBiotechnology
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
Owner:PRECIGEN INC
Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Induction of gene expression using a high concentration sugar mixture
Owner:GENENCOR INT INC
Multiple inducible gene regulation system
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
Owner:RHEOGENE INC DE
Stem-regulated, plant defense promoter and uses thereof in tissue-specific expression in monocots
InactiveUS20070016979A1Strong specificityDriving expression of insecticidal proteinsBacteriaFermentationBiotechnologyTissue specific
The invention is directed to isolated promoters from stem-regulated, defense-inducible genes, such as JAS promoters. The promoters are useful in expression cassettes and expression vectors for the transformation of plants. Particularly, the invention provides transgenic plants of rice and sugarcane that have been modified such that expression of a heterologous coding sequence is directed by an JAS promoter and is limited to stem tissues or may be upregulated by the presence of a defense-inducing agent. The invention also discloses methods for producing the expression vectors and transgenic plants.
Owner:TEXAS A&M UNIVERSITY
Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
InactiveUS20080263687A1FungiFusion with DNA-binding domainHigh-Throughput Screening AssaysBiotechnology
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:RHEOGENE INC DE
Novel ecdysone receptor-based inducible gene expression system
Owner:RHEOGENE INC DE
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
ActiveUS20080145935A1Improve efficiencyGreat degree of sequence similarityPeptide/protein ingredientsTissue cultureHigh-Throughput Screening AssaysGenomics
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:RHEOGENE INC DE
Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:PRECIGEN INC
Novel ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor / invertebrate retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:RHEOGENE INC DE
Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
ActiveUS8076517B2Inhibit expressionUrea derivatives preparationOrganic active ingredientsGene expression levelOrganism
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
Owner:PRECIGEN INC
Induction of Gene Expression Using a High Concentration Sugar Mixture
Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
Owner:ENGLAND GEORGE R +2
Arabidopsis argos, a novel gene involved in organ development
The present invention is directed to a novel auxin-inducible gene, ARGOS, that is involved in organ development, including size control, in plants. Methods of influencing this development are also described, as are transformed cells and transgenic plants comprising the described sequences.
Owner:TEMASEK LIFE SCIENCES LABORATORY
Compositions and methods for inducing gene expression
InactiveUS7053062B2High expressionIncreased formationVirusesFusion with DNA-binding domainA-DNABiological activation
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and / or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
Owner:GENZYME CORP
Multiple Inducible Gene Regulation System
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
Owner:RHEOGENE HLDG
Novel substitution mutant receptors and their use in an ecdysone receptor-based inducible gene expression system
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Owner:PRECIGEN INC
Method for selective expression of therapeutic genes by hyperthermia
A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide encoding a therapeutic polypeptide, wherein the polynucleotide is operatively linked to a heat-inducible promoter; (b) administering the construct to a warm-blooded vertebrate at a site at or near the tumor; and (c) applying heat to the site at or near the tumor to express the therapeutic polypeptide, whereby anti-tumor activity is observed.
Owner:DUKE UNIV
Inducible expression vectors and methods of use thereof
The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.
Owner:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZONA
Transcription factors, DNA and methods for introduction of value-added seed traits and stress tolerance
Abscisic acid-inducible gene expression in different plant tissues is enhanced synergistically by the co-expression of a B3-domain transcription factor and various bZIP-domain transcription factors, or a different B3-domain transcription factor. Using these transcription factors in novel formulations, as shown by examples, will confer value-added traits to transgenic plants, including, but not limited to, higher levels of heterologous gene expression, drought and salt tolerance, viability and productivity under stress, and enhanced nutrient reserves and seed properties.
Owner:TEXAS TECH UNIVERSITY
Corn drought inducible gene promoters and activity analysis thereof
InactiveCN102154289ASolving the food crisisSolve problems such as ecological deteriorationVector-based foreign material introductionAngiosperms/flowering plantsBiotechnologyDNA fragmentation
The invention discloses corn drought inducible gene promoters and activity analysis thereof, which belong to the technical field of bioengineering. The invention provides the sequences of the obtained corn drought inducible promoters and provides a drought inducible plant expression vectors for corn transfer, and a transgenic plant transferred by the plant expression vector and polymerase chain reaction (PCR) primers suitable for amplifying a DNA fragment having a sequence SEQ ID No.1. The prompters can be used for promote the high-efficiency expression of an anti-drought gene, are used in drought-resistance transgenic plants and have an active significance for solving food crisis, ecological deterioration and the like in drought areas.
Owner:JILIN UNIV
Diacylhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
Owner:PRECIGEN INC
Tobacco PDS gene fragment-containing cucumber mosaic virus RNA2 attenuated mutant type plasmid vector and application thereof
ActiveCN108486148AMeet basic requirementsSsRNA viruses positive-senseVirus peptidesNicotiana tabacumPlasmid Vector
The invention discloses a tobacco PDS gene fragment-containing cucumber mosaic virus RNA2 attenuated mutant type plasmid vector and application thereof. The plasmid vector contains a CMVFny strain RNA2 complete sequence, and a tobacco PDS gene 199bp fragment is inserted behind a 2a protein termination codon. The plasmid vector and a wild CMVFny RNA1 and wild CMVFny RNA3-containing plasmid are inoculated to nicotiana benthamiana through an agrobacterium infiltration method, so that weakly pathogenic symptoms can be displayed, and the capacity of inducing gene silencing can be judged with nakedeyes without depending on an instrument; great convenience is provided for deep researches on attenuated vaccines.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Riboswitch inducible gene expression
InactiveUS20180119156A1Rapid substantial cassationPromote growthVector-based foreign material introductionAptamerIntein
An intronic, self-splicing riboswitch is configured for enzyme-product specificity by introducing an appropriate aptamer. This then provides a sensing-expression construct, whereby the presence of an enzyme product in the cell triggers self-splicing of the intron sequence to restore the reading frame of the reporter gene and as such to drive expression of the gene product. The sensing construct expresses a protein which marks the cell or permits its growth or survival in or on an otherwise selective media. In this way, introduction or the presence of such product sensing-reporter constructs in cells can be harnessed to provide a multi-parallel rapid screening of cells or libraries for desirable enzyme variants.
Owner:WAGENINGEN UNIV
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Owner:RHEOGENE INC DE
Boron-Containing Diacylhydrazines
The present disclosure provides boron-containing diacylhydrazines having Formula I:and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
Owner:PRECIGEN INC
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