200 results about "Heat shock" patented technology

The invention provides recombinant IV-type collagen as well as a preparation method and application thereof, and relates to the technical field of biochemical engineering. The preparation method of the recombinant IV-type collagen comprises the following steps: obtaining a codon from amino acid of the recombinant IV-type collagen, further obtaining a target gene, and synthesizing the target gene onto an expression vector to obtain a plasmid; transferring the plasmid into an expression host, and screening a positive transformant to obtain an expression strain; and culturing the expression strain, and expressing the target protein to obtain the crude recombinant IV-type collagen. The high-purity recombinant IV-type collagen is prepared through a genetic engineering technology, and the recombinant IV-type collagen can significantly down-regulate inflammatory factors and reduce inflammation; heat injury can be reduced by up-regulating heat shock protein; after heat injury, the recombinant IV-type collagen can obviously lower metal matrix protease of heat injury cells, and also can obviously promote gene expression of type I collagen and type III collagen, improve skin elasticity and moisture content and delay skin aging.

The present application relates to a kind of heat shock flash evaporation loop lift membrane heat exchange test system, including heat exchange pipe, vapor-liquid separator, condenser, metering barrel, vacuum pump, liquid tank, heat shock heater, throttle valve, measurement and control system and high-speed camera, the upper outlet of heat exchange pipe is connected with the import of vapor-liquid separator, the secondary steam outlet of vapor-liquid separator is connected with the hot medium side import of condenser, the hot medium side outlet of condenser is connected with metering barrel and liquid tank respectively, the concentrated liquid outlet of vapor-liquid separator is connected with liquid tank, the outlet of metering barrel is connected with liquid tank, vacuum pump is connected with liquid tank, liquid tank is connected with heat shock heater, heat shock heater is connected with heat exchange pipe, throttle valve is arranged between heat shock heater and heat exchange pipe;High-speed camera is arranged in one side of heat exchange pipe.The present application can realize the experimental test to heat shock flash evaporation loop lift membrane heat exchange technology, and provide support for mechanism research, equipment optimization of heat shock flash evaporation loop lift membrane heat exchange technology.

The invention discloses a method for ultrafast synthesizing pyrochlore type and perovskite type oxides based on Joule heat, which comprises the following steps of: firstly, obtaining a solid precursor by adopting a coprecipitation method, then quickly heating the solid precursor to 700-800 DEG C by using a Joule heat shock technology, cooling to room temperature, and circulating heating-cooling operation for a plurality of times to prepare a series of pyrochlore type (A2B2O7) and perovskite type (ABO3) oxides; the synthesis time is extremely short (lt; the method has the advantages of high yield (more than 2500g / h), high energy efficiency and potential to realize the purpose of high-flux synthesis, and has a good industrial production basis and a wide application prospect.

The present application relates to a kind of heat pump rectification systems based on heat shock flash circulation lift heat exchange, including rectifying tower, lift membrane reboiler, first throttling valve and heat shock heater, the secondary steam outlet of rectifying tower is connected with the heating steam import of lift membrane reboiler, the discharge port of the bottom of rectifying tower is connected with the cold side flow channel import of heat shock heater, and the cold side flow channel export of heat shock heater is connected with the feed inlet of lift membrane reboiler by first throttling valve;The vapor-liquid mixture outlet of lift membrane reboiler is connected with the column still liquid reflux port of rectifying tower, and the steam condensate outlet of lift membrane reboiler is connected with condensate tank, and the liquid outlet of condensate tank is connected with the condensate reflux port of rectifying tower side wall.The present application is combined by heat shock pressurization energy storage and throttling flash kinetic energy release, provides independent and stable lift membrane kinetic energy for lift membrane heat exchange, so that the flow pattern in the tube of lift membrane reboiler directly enters the efficient annular flow stage, improves the industrial applicability of lift membrane heat exchange technology in heat pump rectification system.

The present application relates to a kind of hot exciting flash evaporation loop lift heat exchanger, including upper head, lower head, cylinder, several heat exchange tubes, the upper end surface of cylinder and the upper head form cavity I between, the lower end surface of cylinder and the lower head form cavity II between, cavity I, cavity II and the inner cavity of cylinder are not communicated with each other between, heat exchange tube is fixed in the inside of cylinder by tube sheet, the upper end of heat exchange tube is placed in cavity I and is communicated with cavity I, lower end and cavity II are communicated, cylinder includes lift section cylinder and hot exciting section cylinder, heat exchange tube includes lift section heat exchange tube and hot exciting section heat exchange tube, lift section heat exchange tube and hot exciting section heat exchange tube are communicated by throttling component between, the inner diameter of throttling component is less than the inner diameter of hot exciting section heat exchange tube.The heat exchanger of the present application is provided with a kind of hot exciting flash evaporation loop lift, will hot exciting pressurization energy storage, throttling flash evaporation kinetic energy release, loop lift heat exchange and vapor-liquid separation function integration in same equipment, solve the problem of traditional lift section heat exchanger dependence big temperature difference.

The invention relates to the technical field of medical waste treatment, in particular to a microwave and steam medical waste continuous treatment process which comprises the following process steps: S1, conveying: conveying medical wastes from a feeding system into a crushing system through an elevator for crushing; s2, crushing, wherein the crushed medical waste is conveyed to a sterilization system through a conveying system for sterilization treatment; s3, sterilization is conducted, specifically, when the medical waste reaches a sterilization system, high-temperature and high-pressure steam is introduced into a sterilization bin; s4, exhausting: starting a circulating air pump to pump out harmful gas in the sterilization bin for purification; and S5, after inspection and sterilization are completed, the medical waste is discharged out of the sterilization bin through a discharging pipe. According to the medical waste sterilization device, the interior of the sterilization bin can be kept in a high-temperature and high-pressure state, so that bacteria in medical waste are sterilized, the equipment stability is good, damage caused by cold and heat shock is avoided, and meanwhile the problems of extremely low treatment capacity, high energy consumption, large leakage amount and the like caused by previous intermittent treatment are solved.

The invention discloses a dynamic permeability testing system and method for hydrate core production by a pressure reduction or heat shock method, and the system comprises a dynamic permeability testing unit (1) which is used for the preparation of a natural gas hydrate core sample and the measurement of permeability; the gas and liquid injection unit (2) is used for injecting required gas and liquid into the dynamic permeability testing system; the hydraulic oil control unit (3) is used for applying axial pressure and confining pressure to the dynamic permeability testing system; the gas-liquid separation metering unit (4) is used for metering the gas-liquid flow at the outlet; and the data acquisition monitoring and control unit (5) is used for monitoring data of each unit and controlling each unit to work. According to the invention, the natural gas hydrate-containing rock core can be subjected to pressure drop under the triaxial stress condition or the production dynamic permeability test by a heat shock method.

The invention discloses a method for obtaining a sorted and purified autoimmune vaccine, which comprises the following steps: S1, extracting 30ml of autologous blood sample of a patient, and sorting to obtain CD34 + cells; s2, carrying out flow analysis on the CD34 + cells to ensure that CD34 + is greater than or equal to 90%, counting by using a counting instrument, and adjusting the concentration of the CD34 + cells to be 1 * 106 / mL; s3, the extracted cells are placed in a 42 DEG C constant-temperature water bath kettle for heat shock treatment, and the heat shock treatment lasts for two hours; s4, collecting the cells obtained in the step S3, transferring the cells into liquid nitrogen at-196 DEG C and a water bath kettle at 37 DEG C, and repeatedly freezing and thawing for multiple times; s5, collecting after detecting that no living cells exist by using a cell counter, and centrifuging for 10 minutes at the rotating speed of 6000 r / min under the centrifugal condition of 4 DEG C; s6, after the centrifugation is finished, discarding the supernatant and leaving the precipitate, and resuspending by using normal saline; and S7, irradiating 200 GY through gamma rays for 60 minutes, collecting the sample, sending the sample, and inspecting the sample for later use after the sample is qualified.

The application provides a steam condensate waste heat recycling device, and relates to the field of heat energy recovery.The steam condensate waste heat recycling device comprises a base, a heat preservation cylinder arranged on the base, and a synchronous adjusting mechanism arranged on the heat preservation cylinder.The steam condensate waste heat recycling device can conveniently collect condensate water into a required device, and the high-temperature condensate water can not lose a large amount of heat through a pipeline and a surface of equipment during a transmission process, so that heat energy is not wasted.The synchronous adjusting mechanism drives a conveying pump to quickly transfer the condensate water in the heat preservation cylinder to a required place, so that the condensate water recovery efficiency is improved.The synchronous adjusting mechanism solves the problem of waste of condensate water waste heat in the prior art.The synchronous adjusting mechanism solves the problem of equipment damage caused by heat shock in the prior art.The synchronous adjusting mechanism solves the problem of increased thermal resistance caused by scale accumulation in the prior art.

The invention discloses a purification method of bovine serum albumin. The purification method comprises the following steps: S1, pre-treating bovine plasma to remove impurities and fibrin; s2, adsorption with tourmaline or sepiolite; s3, protein precipitation through heat shock; and S4, carrying out heparin-agarose chromatography. The bovine serum albumin sample is purified by combining tourmaline or sepiolite with heparin-agarose chromatography, nuclease in the bovine serum albumin sample can be removed, and the product purity is improved; and one-step heat shock is combined with heparin-agarose chromatography, so that the energy consumption is reduced, reagents such as ethanol influencing the protein activity are prevented from being used, the recovery yield is high, and large-scale production is facilitated.

The invention belongs to the technical field of nano material synthesis and volatile organic compounds (VOCs) degradation, and particularly relates to a method for preparing a high-entropy spinel / biochar composite material by using a Joule thermal shock method and application of the high-entropy spinel / biochar composite material. The preparation method comprises the following steps: firstly, forming gel from metal salt precursors and biomass through a sol-gel method, and then rapidly synthesizing the precursors into the high-entropy spinel by adopting Joule thermal shock. The biochar in the composite material prepared by the invention is of a wormlike lamellar structure, and the high-entropy spinel is polygonal particles and is uniformly loaded on the biochar. Due to the high-entropy effect and lattice distortion effect of the composite material, the number of oxygen vacancies of the material can be obviously increased, defect sites can be formed on the surface of the material through instant energy impact, the catalytic performance of the material can be improved, and the catalytic material can efficiently convert methylbenzene into carbon dioxide and water.

The invention discloses a device and a method for testing thermal shock resistance and thermal erosion resistance of a material. The box body is used for providing a closed test chamber; the sample testing platform and the laser head are arranged in the testing chamber, the sample testing platform comprises a rotating shaft and a rotating testing table for loading a testing sample, and the rotating testing table is coaxially and fixedly connected to the rotating shaft; the laser head is arranged above the rotary test table and is connected with a main body of a laser generating device outside the box body, and the laser generating device carries a powder feeding system for feeding out test powder; the rotary driving mechanism is used for driving the rotating shaft to rotate, so that the laser emitted by the laser head periodically acts on a test sample on the rotary test table; and the cooling mechanism is used for cooling the rotary test bench. According to the testing device and the testing method provided by the invention, the working environment of thermal shock and thermal erosion of the material in long-term production can be truly restored and simulated, so that the thermal shock resistance and thermal erosion resistance of the material are tested.

The invention discloses a double-report plasmid system and a construction method and application thereof. The double-report plasmid system comprises a translation report plasmid and an error folding response plasmid; the translation reporter plasmid comprises a target protein gene sequence, an mRNA secondary structure sequence and a luciferase gene sequence; the misfolding response plasmid comprises a heat shock pressure promoter and a fluorescent protein gene. The double-report plasmid system can quantitatively and visually detect translation characteristics and wrong folding conditions of the recombinant protein, the whole operation process is carried out based on a 96-well plate, the double-report plasmid system has the characteristics of low cost, high timeliness, high flux and the like, and the recombinant protein can be rapidly and efficiently soluble (positive: complete soluble; negative: completely insoluble; and in an intermediate state, the solubility is relatively poor), so that the efficiency of recombinant protein expression research is greatly improved.

This invention discloses a method for large-scale breeding of all-female triploid mandarin fish, comprising the following steps: (1) Preparation of all-female diploid fertilized eggs: using male mandarin fish pseudo-males (XX) induced by androgens and female mandarin fish (XX) selected from superior strains as parent fish, collecting sperm and eggs, mixing the two, adding water at a temperature of 28℃ to activate sperm for fertilization, and obtaining all-female diploid fertilized eggs; (2) Heat shock induction of triploids: after the all-female diploid fertilized eggs are fertilized in the above-mentioned water at a temperature of 28℃ for 8 minutes, they are immediately transferred to water at a temperature of 39~41℃ for 1~2 minutes for heat shock induction, and all-female triploid fertilized eggs are obtained; (3) Seedling hatching and cultivation: the fertilized eggs induced by heat shock in step (2) are transferred to the hatching system for hatching, and then conventional seedling cultivation is carried out to obtain all-female triploid mandarin fish seedlings. The mandarin fish fry produced by this method have a high female rate, triploid rate, and survival rate.

A system for treating various medical conditions in humans includes a medical or therapeutic laser operating at wavelengths in the near infrared range of between 1250 nm-1267 nm, with a target wavelength of 1260 nm, at power levels between 2 Watts and 60 Watts, and for a period not to exceed 60 seconds per dose. The emitted laser light energizes, e.g., the stem cell niche or mitochondria of the human tissue to which it is applied, both directly and indirectly via activation of cell signaling intermediaries including but not limited to heat shock proteins, thereby stimulating cell activity to promote healing and reduce pain. In this specific wavelength range, water absorption of the laser light energy is plateaued which effectively acts as a conduit allowing the laser light energy to be transferred deeper into the tissue without causing thermal damage to the skin and tissue.

The application discloses a kind of cultivation methods of konjak, belong to konjak planting technical field, the present application is to the pretreatment konjak seed potato of sterilization in nitrogen and ozone mixed atmosphere steam treatment, not only strengthen the growth potential of konjak seed potato, and fully activated the catalase in seed potato, create excellent intracellular environment for promoting subsequent seed potato germination, heat shock seed potato is soaked in activation liquid and activated, brassinolide, calcium sulfate, ethiofencarb and sodium complex nitrophenol in activation liquid activate the cytokinin oxidase in cell, and then regulate seed potato germination speed and germination quality, effectively solve the problem of low seedling rate of offspring konjak and yield decline.The activation seed potato is sowed in nutrient soil, effectively improves the content of nutrient substance in harvested konjak.

The utility model relates to a thermal shock resistance testing device for a thermal contraction belt or sleeve, which comprises a support, a shaft rod, a pressing sheet and a sample strip, two ends of the shaft rod are rotatably arranged at the top of the support through bearing seats, the sample strip is tightly pressed by the pressing sheet and is tightly attached to the outer circle of the shaft rod, the pressing sheet is fixed with the shaft rod through a screw, and a handle is eccentrically arranged at one end of the shaft rod. According to the utility model, the test process is simplified, the sample strip is hung on the rotatable shaft rod, and the sample strip is bent while whether the sample strip flows or drops is observed, so that the crack test of the sample strip is facilitated, the test efficiency is greatly improved, and the device is suitable for batch test.

This invention discloses a method for efficiently inducing allopolyploid fish fry, belonging to the field of fish breeding technology. The method of this invention includes the following technical steps: (1) Induction of spawning in distant hybridization parents: Selecting female and male parent fish from different subfamilies of Cyprinidae, and collecting mature eggs and semen respectively; (2) Obtaining hybrid fertilized eggs: Mixing the collected eggs with semen, and performing dry artificial insemination to obtain hybrid fertilized eggs; (3) Inducing allopolyploidy: Placing the fertilized eggs in a water bath for heat shock treatment to inhibit the expulsion of the second polar body or inhibit the first cleavage, and then quickly transferring the treated fertilized eggs to aquaculture water to continue hatching fry. The method of this invention combines the method of distant hybridization between subfamilies with the method of heat shock induction. After induction using this method, the multiplication rate of hatched fry can reach 100%, which significantly improves the yield of allopolyploid fish fry from distant hybridization.

The invention discloses an automatic cell transformation work station and a working method thereof, and belongs to the technical field of molecular biology experiment automation, the automatic cell transformation work station comprises a work station box body, the work station box body is internally provided with a constant temperature oscillation mechanism, a metal bath mechanism, two water bath mechanisms, a pipetting mechanism and a transfer mechanism; the pipetting mechanism is used for adding each sample into the deep hole plate; the constant-temperature oscillation mechanism is used for performing oscillation recovery culture on a sample in the deep-hole plate at a constant temperature; the metal bath mechanism is used for carrying out constant-temperature heat preservation on a sample in the PCR plate; the two water bath mechanisms are respectively used for carrying out cold bath treatment and heat shock treatment on a sample in the deep hole plate; and the transfer mechanism is used for transferring the deep-hole plate. The device integrates constant-temperature oscillation, metal bath heat preservation, water bath cold shock and water bath heat shock, the automation degree of an experiment is improved, human intervention is reduced, the pollution risk is reduced, and the experiment efficiency is improved.

This invention relates to the field of aquatic product deep processing technology, and discloses a squid salad processing method based on gradient temperature cooking. The squid salad is made from cooked squid rings, mixed vegetables, and a salad dressing containing a specific compound emulsifying stabilizer. The processing method includes: subjecting pre-treated squid to acoustic-thermal coupled gradient cooking, sequentially undergoing three stages: ultrasonic-assisted low-temperature sol-gelation, silent medium-temperature heat-induced gelation, and high-temperature safe setting; subsequently, immediately immersing it in an ice-water mixture for gradient heat-blocking cooling, draining, and then mixing with the dressing. This invention effectively solves the problems of severe moisture loss and tough texture in traditional processes by precisely controlling the timing of ultrasonic intervention and three-stage temperature control, combined with the heat shock effect, giving the product a crispy exterior and tender interior texture. Simultaneously, the use of compound stabilizers improves the emulsification stability and water-holding capacity of the dressing in a high-humidity matrix, increasing the yield of the finished product.

The application discloses a low-temperature constant-temperature cold source utilizing adsorption latent heat, which is provided with an adsorption container filled with an adsorbent and filled with a working gas, and utilizes the adsorption latent heat generated when the working gas is desorbed to provide the cold source. The low-temperature constant-temperature cold source utilizes the adsorption latent heat generated when the working gas is desorbed to provide the cold source for a cooling platform. The application does not have any active moving parts, and has the characteristic of no vibration; the adsorption of the working gas on the surface of the adsorbent can occur in a wide temperature range higher than the boiling point of the working gas, so that the cooling can be provided in a wide temperature range; the utilization of the adsorption latent heat as the cold source can cope with greater heat shock, has better temperature stability, and has the advantages of simple device structure, easy-to-obtain material, convenient operation, low cost and the like.

To provide a heating control device, a heating control method and a program enabling energy saving while suppressing heat shock to a user.SOLUTION: A cloud server 1 includes: a hot water filling start detection section 2111 that detects start of hot water filling; a temperature acquisition section 2114 that acquires indoor temperature information indicating a temperature of at least one of a bathroom and an undressing room and a room temperature information indicating a temperature of a room of a user when the start of hot water filling is detected; a heating necessity determination section 2115 that determines the necessity of heating at least one of the bathroom and the undressing room on the basis of the indoor temperature information and the room temperature information; and a control information generation section 116 that generates control information for controlling at least one of a bathroom heating device installed in the bathroom to heat the bathroom and an undressing room heating device installed in the undressing room to heat the undressing room when the heating necessity determination section determines the necessity of heating at least one of the bathroom and the undressing room.SELECTED DRAWING: Figure 16

The invention discloses engineering probiotics for targeted therapy of colitis and a construction method and application thereof.The construction method of the engineering probiotics for targeted therapy of colitis comprises the following steps that 1, PelB and optimized Fc and IL-4 genes are connected with homologous arms through PCR, seamless cloning is conducted, and then the PelB and optimized Fc and IL-4 genes are inserted into pBAD33 plasmids to construct recombinant plasmids; step 2, transferring the plasmids obtained in the step 1 into competent E.coliDH5alpha through a heat shock method, carrying out sequencing verification after bacterial colony PCR verification, so as to determine whether the recombinant plasmids are successfully constructed or not; and step 3, under the condition that the recombinant plasmid is successfully constructed, transferring the recombinant plasmid into competent EcN by utilizing a heat shock method, screening by adopting a chloramphenicol-resistant LB solid plate, culturing a bacterial colony obtained by screening in an LB liquid culture medium containing chloramphenicol, and centrifugally collecting and storing. The invention realizes the characteristics of targeting an inflammation site and treating inflammation.

The scheme relates to a method for producing soluble human acetaldehyde dehydrogenase 2 in escherichia coli in the field of enzyme engineering, and the method comprises the following steps: firstly, inserting a human ALDH2 gene into a pET30a (+) plasmid through Nde I and Xho I restriction enzyme cutting sites to form a recombinant expression vector; then, transforming the recombinant vector into escherichia coli by utilizing a heat shock method, and screening out recombinant engineering bacteria which are correctly sequenced; and finally, inoculating and culturing the engineering bacteria under proper conditions, adding lactose as an inducer (the final concentration is 0.2-0.3 mM), inducing for 4-8 hours under the conditions of 25-35 DEG C and 100r / min, and then collecting thalli. The thalli are suspended by a buffer solution, treated by a cell crusher and centrifuged to obtain crude enzyme, and the crude enzyme is further purified to obtain the soluble recombinant human-derived ALDH2. According to the method disclosed by the invention, the production of the soluble humanized acetaldehyde dehydrogenase 2 from the escherichia coli is realized.

A germinant composition for activating one or more wild-type and / or super-dormant spores, particularly Bacillus spores, comprises L-isoleucine or L-valine or both. A germinant composition may also comprise a buffer, a source of potassium, an industrial preservative, and one or more other L-amino acids. Wild-type and / or super-dormant spores may be incubated with a germinant composition by heating to an incubation temperature of 26 to 60° C. for an incubation period of 30 minutes to 36 hours. Incubation may be a single step process without pre-activation or heat shock or a two-step process. A method of pre-activation comprises combining spores with a germinant composition and either bioprocessing or heat treating and then drying. An incubated bacteria solution preferably comprises at least 50% activated spores after an incubation period of 24 hours and more preferably after 1 hour.

An agent for modulating expression of a heat shock protein gene, comprising a Lactobacillus sp. derived from Artemisia indica var. maximowiczii or Angelica keiskei. Also described are compositions comprising the same, as well as methods of making and using such agents and compositions.

The utility model discloses an experimental device for detecting the thermal shock performance of a protective coating. The experimental device comprises an experimental table, a cooling water tank, a motor, a turntable, a connecting rod and a flame spray gun, the experiment table comprises a frame body, a table plate and a supporting plate; an avoiding hole is formed in the table plate, the bottom end of the cooling water tank is fixed to the supporting plate, and the top end of the cooling water tank upwards penetrates out of the avoiding hole and is provided with a cooling water filling opening; the motor is fixed on the bedplate; the turntable is positioned above the cooling water filling port and is in transmission connection with an output shaft of the motor; the connecting rods are radially arranged along the turntable, first ends of the connecting rods are fixed on the turntable, clamps are fixed at second ends of the connecting rods, and the clamps can clamp a to-be-tested metal piece coated with a protective coating; the flame spraying gun is installed on the platen, and the flame spraying end of the flame spraying gun faces the rotating disc. The experimental device for detecting the thermal shock performance of the protective coating disclosed by the utility model is time-saving and labor-saving, and a metal piece to be detected coated with the protective coating can be rapidly and repeatedly heated and cooled.

This invention relates to the field of cosmetics, specifically to a composition containing copper peptides for repairing photothermal damage and its application. The composition comprises a complex polypeptide, galactosomal yeast fermentation product filtrate, and cyanobacterial extract; wherein the complex polypeptide includes copper peptides, yeast polypeptides, and hexapeptide-11. This invention, by combining specific complex polypeptides with galactosomal yeast fermentation product filtrate and cyanobacterial extract, increases the expression level of heat shock proteins, thereby achieving excellent efficacy in repairing photothermal damage. Furthermore, this composition is mild and non-irritating, and can be widely used in cosmetics.

Compounds, compositions and methods for improving the viability and / or function of cells or for the in vitro, ex vivo or in vivo protection of cells, tissue, graft or organs from various damages are described. The reagents and composition are based on activation of the heat shock response activation and / or the antioxidant response and include for example. HSP90 co-factor inhibitor such as Celastrol or Celastrol analogs used alone or in combination with an adjunct agent (e.g., a NRF-2 activator, antioxidant, etc.). Therapeutic enhancement may also include increase in paracrine effector production and signaling. Methods for improving the resistance of cells, tissue, grafts or organs to damages or stress, such as hypoxic or oxidative stress-induced cell death, and / or for improving the viability and retention of transplanted or transfused cells are also described. Therapeutic treatment or prevention of ischemic injury (e.g. myocardial infarct, ischemia / reperfusion injury) and related stressors (hypoxia, oxidative stress, inflammation, sepsis / shock, etc) are also provided.