17 results about "Autoimmune Reactions" patented technology

The invention provides a pharmaceutical composition for bone joints as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following components in parts by weight: 20 to 2000 parts of N-acetylglucosamine and 10 to 1000 parts of non-denatured type II collagen. In the compound composition of the N-acetylglucosamine and the non-denatured type II collagen, the two core components play a complementary role: the N-acetylglucosamine is focused on promoting synthesis of a cartilage matrix and provides a material basis for cartilage repair; the non-denatured type II collagen reduces damage of autoimmune response to cartilage through immunoregulation, the non-denatured type II collagen and the non-denatured type II collagen have a synergistic effect, the symptoms such as arthralgia and swelling can be relieved, the joint structure can be improved from the double angles of repairing and protecting, and particularly the treatment effect on patients with severe osteoarthritis is remarkably superior to that of a single-component preparation; and an innovative and efficient choice is provided for the treatment of osteoarticular diseases.

The present invention relates to the field of medical technology, and specifically to the use of salvianolic acid B in the preparation of drugs for treating IPEX. The present invention proves through in vivo animal experiments that salvianolic acid B has a good anti-inflammatory effect and can effectively alleviate the autoimmune reaction of Treg-deficient SF mice. In the present invention, the cations in the salvianolic acid B salts can be iron ions, calcium ions, sodium ions, potassium ions or magnesium ions, preferably magnesium ions; the dosage form of the drug for treating IPEX can be any dosage form described in pharmacy, and can be an oral liquid form, an injection form, a tablet form or a capsule form. By utilizing the key role of salvianolic acid B in IPEX disease, it can be prepared into a drug, providing a theoretical basis and a new treatment idea for the treatment of primary immunodeficiency diseases with traditional Chinese medicine; salvianolic acid B is easy to obtain, can be quickly put into production and obtain a high-efficiency preparation, and has important application value.

The present invention relates to a composition for preventing or treating autoimmune diseases. In particular the present invention relates to a composition that prevents or treats the disease by specifically targeting the immune cells responsible for the autoimmune reaction. Thus one aspect relates to a composition comprising DDA and TDB or MMG, retinoic acid or analogues thereof, and at least one autoimmune antigen for use in prevention or treatment of autoimmune diseases.

The present disclosure provides, inter alia, molecules comprising an autoantibody binding domain and at least one modified Fc domain. The present disclosure also provides methods and compositions that allow for selective depletion and / or neutralization of pathogenic autoantibodies.

The present invention relates to a CAR and to regulatory T-cells (Treg) expressing the CAR for use in the treatment of multiple sclerosis (MS) and / or Alzheimers disease (AD). The CAR, especially Treg expressing the CAR, are suitable for suppressing adverse immune reactions occurring in MS and / or AD due to the high specificity of the CAR for myelin basic protein (MBP) or myelin oligodendrocyte glycoprotein (MOG), which are primary targets of autoimmune reactions in MS and AD.

The invention discloses a drug-induced autoimmune response prediction method based on oversampling and classification modeling. The method comprises the steps that a drug-induced autoimmune response data set is acquired and preprocessed; the SNN-DPC is adopted to cluster the preprocessed data set; according to the JS divergence, selecting and marking clusters with class distribution similar to global distribution, and calculating the number of samples needing to be generated for the marked clusters based on a Kulczynski index and Gaussian density; synthesizing an oversampling sample in the mark cluster through density weighted three-point interpolation; performing LOF noise removal on the synthetic samples and rejecting boundary samples to form a balanced data set; and training and selecting an optimal classifier to construct a prediction model, and outputting a prediction category and probability. According to the method, data distribution is balanced through generated high-quality minority samples, the recognition capability of a classification model on drug-induced autoimmune positive samples is effectively enhanced, the accuracy of drug immunotoxicity prediction is greatly improved, and immunotoxicity evaluation in the drug research and development process can be assisted.

The invention generally relates to a novel ‘One Process’ for production of polypeptides comprising an anti-idiotypic, mirror image of the antigenic determinants of an agent of interest such as a disease-causing agent. In particular, the polypeptides are used to pre-treat samples prior to indirect ELISA assays and in its incorporation in vaccines. When used in indirect ELISA assays, the result is a significant reduction in false positives, while its inclusion in vaccines provides an additive induction of immunity in humans and different animal species by the proteinaceous mirror image of weak immunogens including, lipid, carbohydrate, and low molecular weight molecules of the agent of interest. The incorporation of anti-idiotypes produced by the ‘One Process’ in vaccines induces antibodies that is used in cocktail of therapeutics for treatment of injurious antigens and autoimmune reactions in humans and animals.

The application discloses a cell membrane modified nanocomposite as well as a preparation method and application thereof. The nanocomposite comprises, from outside to inside, a membrane structure outer layer, a piezoelectric material middle layer and a magnetostrictive material core structure, wherein the outer surface of the membrane structure contains protein molecules. Under the stimulation of an external magnetic field, the nanocomposite can regulate Th1 / Th2 balance, promote Th2 cell polarization and enhance T cell proliferation, thereby reducing T cell-mediated autoimmune reactions and maintaining host immune homeostasis, and has a wide application prospect in the treatment of arthritis.

Provided herein are methods and compositions involving chromene derivatives acting as TCR or TCR-Nck inhibitors, and CAR-T therapies. The provided methods include the use of a chromene derivative in combination with a CAR-T therapy for treating a disease or disorder, for preventing or reducing an autoimmune reaction associated with a CAR-T therapy, and for increasing or improving a CAR-T therapy effectiveness.

The present invention relates to a CAR and to regulatory T-cells (Treg) expressing the CAR for use in the treatment of multiple sclerosis (MS) and / or Alzheimers disease (AD). The CAR, especially Treg expressing the CAR, are suitable for suppressing adverse immune reactions occurring in MS and / or AD due to the high specificity of the CAR for myelin basic protein (MBP) or myelin oligodendrocyte glycoprotein (MOG), which are primary targets of autoimmune reactions in MS and AD.

The application discloses a use of an active ingredient in repairing heart tissue damage. Specifically, the application discloses an active ingredient which can be used for repairing heart tissue damage and treating diseases related to lymphatic vessel abnormalities, and the active ingredient comprises a TBX1 protein, a coding sequence of the TBX1 protein, or a promoter of the TBX1 protein, or a combination thereof. The TBX1 protein can promote the proliferation of heart lymphatic vessel endothelial cells, play an immune regulation role, promote the establishment of an immune inhibition microenvironment in myocardium after heart tissue damage, inhibit an autoimmune reaction after the heart tissue damage, relieve concurrent heart tissue inflammation, and promote the repair and regeneration of the damaged heart tissue.

The present disclosure is directed to the identification and use of lipids involved in auto-immune reactions and foreign body responses. A. set of phospholipids was observed to preferentially deposit on immune-evasive implants, and these phospholipids upregulated RNA transcripts of anti-inflammatory proteins in murine macrophages. Additionally, a set of fatty acid lipids was observed to preferentially deposit on immunogenic implants, and these fatty acid lipids upregulated RNA transcripts of inflammatory proteins in murine macrophages. Using selected lipids, implantable devices can be engineered to avoid or to attract host immune responses, thereby regulating the length of time the devices are maintained in vivo.

The present invention relates to a composition for preventing or treating autoimmune diseases. In particular the present invention relates to a composition that prevents or treats the disease by specifically targeting the immune cells responsible for the autoimmune reaction. Thus one aspect relates to a composition comprising DDA and TDB or MMG, retinoic acid or analogues thereof, and at least one autoimmune antigen for use in prevention or treatment of autoimmune diseases.

The invention relates to a thymus tissue immune microenvironment B cell and high endothelial minor vein detection kit, which comprises a quantum dot labeled antibody CD19, a quantum dot labeled antibody CD1d, a quantum dot labeled CD31 and a quantum dot labeled PNAd, and after a quantum dot coupled specific antibody is specifically combined with a B cell on a tissue slice sample and an antigen on the high endothelial minor vein, the antibody CD19, the antibody CD1d, the quantum dot labeled CD31 and the quantum dot labeled PNAd can be used for detecting the thymus tissue immune microenvironment B cell and the high endothelial minor vein. The quantification or positioning of B cells and high endothelial small veins by quantum dots can be realized; a traditional multicolor immunofluorescence technology is replaced, a method of directly carrying a specific antibody by using quantum dots is used, the experiment time is saved, and the working efficiency is improved; the thymus immune microenvironment detection kit can detect the expression conditions of B cells and Breg cells in a thymus immune microenvironment and the expression of high endothelial minor veins, can observe the relative spatial positions of the cells and blood vessels, and directly reflects the states of immune infiltration and autoimmune response in the thymus immune microenvironment. Wide application prospects are realized in the fields of thymus related immunity and tumors.

The present disclosure provides, inter alia, molecules comprising an autoantibody binding domain and at least one modified Fc domain. The present disclosure also provides methods and compositions that allow for selective depletion and / or neutralization of pathogenic autoantibodies.

The invention discloses preparation and application of a double-targeting polypeptide drug based on gold nanoparticles, and belongs to the technical field of preparation of leucoderma drugs. MC1R agonist peptide 1 and T96 are coupled to the gold nanoparticles; multiple treatment effects of protecting melanocytes, promoting melanin synthesis and inhibiting autoimmune response can be realized at the same time, and a brand new thought and method are provided for treatment of vitiligo.

The invention discloses a cell membrane modified nano composite material as well as a preparation method and application thereof. The nanocomposite sequentially comprises a membrane structure outer layer, a piezoelectric material middle layer and a magnetostrictive material core structure from outside to inside, and the outer surface of the membrane structure contains protein molecules. Under the stimulation of an external magnetic field, the nano composite material disclosed by the invention can regulate Th1 / Th2 balance, promote Th2 cell polarization and enhance T cell proliferation, so that T cell mediated autoimmune response is relieved, host immune homeostasis is maintained, and the nano composite material has a wide application prospect in treatment of arthritis.