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82 results about "Immunodeficiency" patented technology
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Immunodeficiency is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Most cases of immunodeficiency are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection, extremes of age, and environmental factors, such as nutrition. In the clinical setting, the immunosuppression by some drugs, such as steroids, can be either an adverse effect or the intended purpose of the treatment. Examples of such use is in organ transplant surgery as an anti-rejection measure and in patients suffering from an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune system, or primary immunodeficiency. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone. Immunodeficiency also decreases cancer immunosurveillance, in which the immune system scans the body's cells and kills neoplastic ones.
TGFβ signal convertor
The present disclosure provides improved compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Owner:REGENERON PHARMACEUTICALS INC
Application of vitamin K3 in preparation of medicine for treating psoriasis
PendingCN121401245AOrganic active ingredientsDermatological disorderAntiendomysial antibodiesVitamin K3
The invention belongs to the technical field of biological medicines, and discloses application of vitamin K3 in preparation of a medicine for treating psoriasis. The invention finds that the compound vitamin K3 can obviously inhibit the activation of the STING downstream immune pathway and has an inhibition effect on the activation of the STING pathway. A mouse psoriasis model is formulated according to the absorption and metabolism characteristics of the inhibitor VK3, and it is proved that the VK3 can significantly inhibit the process of psoriasis and up-regulation of an STING pathway at an affected part in a transdermal drug delivery mode. The STING pathway does not belong to a main pathway affecting the course of disease in most non-immunodeficient inflammatory diseases, so that a better treatment effect may be generated by using the STING pathway in combination with a direct treatment drug (such as an IL-17A antibody for psoriasis). The vitamin K3 is simple in chemical structure, mature in production process and low in preparation cost, has more remarkable price advantage compared with biological agents and small-molecule targeting drugs, and has high popularization value and application prospects.
Owner:SUN YAT SEN UNIV
Colu virus attenuated strain and application thereof
PendingCN121628844ASsRNA viruses negative-senseViral antigen ingredientsImmunodeficiencyHumoral immune reaction
The invention provides a Garlu virus attenuated strain and application thereof, and relates to the field of virology and biological medicine. According to the invention, the screened Garlu virus attenuated strain is a natural attenuated strain derived from a tick sample, can grow in Vero cells, has the titer of more than or equal to 107 TCID50 / mL, does not have clinical pathogenicity to an immunodeficient host, and is safe; after the attenuated strain is used as an immunogen for pre-intervention, infection of a lethal virus strain can be avoided, the survival rate is increased to 100%, adverse effects on growth and life of experimental animals are avoided, particularly, a host can be stimulated to generate humoral immunity and cellular immunity at the same time, and the survival rate of the experimental animals is improved. And moreover, broad-spectrum cross-protection efficacy can be generated on Bandavirus lethal virus strains, and a foundation is laid for improvement of research on Bandavirus live vaccines such as the Colu virus and the like.
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI
Lactobacillus casei MY01 with effect of improving immunity and application of lactobacillus casei MY01
The invention belongs to the technical field of probiotics, and particularly relates to a lactobacillus casei MY01 strain with an effect of improving immunity and application of the lactobacillus casei MY01 strain. A new Lactobacillus casei MY01 strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, a zebra fish immunosuppression model is constructed, and research finds that the Lactobacillus casei MY01 strain can increase the number of macrophages, neutrophil and T cells, increase the expression quantity of if n phi 1, if n phi 3 and if ng genes, inhibit the activity of angiotensin converting enzyme, inhibit the expression quantity of if n is greater than 1, and inhibit the expression quantity of if n is greater than 1, so that the new Lactobacillus casei MY01 strain can be used for preparing the new Lactobacillus casei MY01 strain. The potential effect of improving the immunity is realized. Therefore, the strain can be used in the field of medicine, and can be used for developing immunomodulatory drugs and assisting in treating immunosuppression related diseases, such as chronic infection and tumors; the method can also be applied to the health care product industry, develops health care products for enhancing immunity, and helps people to improve autoimmunity and maintain a healthy state.
Owner:GUANGDONG WANWUYI BACTERIA BIOTECHNOLOGY CO LTD
Boletus brownii xylan palmitate as well as preparation method and application thereof
The invention discloses boletus brownii xylan palmitate as well as a preparation method and application thereof. The boletus brownii xylan palmitate is xylan palmitate which is formed by alpha-(1-> 4)-xylose as a main chain, alpha-(1->)-glucose as a branch chain and palmitic acid molecules through ester bonds. The invention further discloses a preparation method of the boletus brownii xylan palmitate and application of the boletus brownii xylan palmitate in the aspect of immunoregulation. The boletus brownii xylan palmitate can be used as a dietary supplement or a food additive for immunodeficiency patients and tumor patients.
Owner:YANTAI UNIV
Multipartite receptor and signaling complexes
PendingUS20250242024A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntigenAutoimmune condition
The present disclosure provides adoptive T cell therapies that have improved architectures for targeting antigens and recruiting multimeric immune signaling complexes for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Owner:REGENERON PHARMACEUTICALS INC
Drug conjugates of imidazo quinoline amine derivatives, compositions and methods thereof
The present invention provides novel drug-linker conjugates and antibody-drug conjugates of imidazo quinoline amine derivatives, which have agonistic activity against Toll-like receptors (TLRs), in particular TLR7 and / or TLR8, also provided are pharmaceutical compositions and methods of treatment against certain diseases or conditions mediated by or associated with TLR7 and / or TLR8 (e.g., graft rejection, autoimmunity, inflammation, allergy, asthma, infection, sepsis, cancer, and immunodeficiency).
Owner:CANWELL BIOTECH LTD
Anti-CD28 antibodies and uses thereof
The invention relates to an anti-CD28 antibody or an antigen binding fragment thereof, and a multispecific antibody constructed based on the antibody or the antigen binding fragment thereof, such as an anti-CD3 * CD28 bispecific antibody and an anti-tumor associated antigen (TAA) * CD3 * CD28 trispecific antibody. The invention also relates to a nucleic acid molecule encoding the antibody or the antigen binding fragment thereof, a vector and a cell comprising the nucleic acid molecule, a pharmaceutical composition comprising the antibody or the antigen binding fragment thereof, and application of the antibody or the antigen binding fragment thereof, especially application of the antibody or the antigen binding fragment thereof in treating tumors or immunodeficiency diseases.
Owner:CYTOCARES (SHANGHAI) INC
Cpg oligodeoxynucleotide with regulating body immune capacity and its application
ActiveCN118909014BOrganic active ingredientsAntibacterial agentsImmunodeficiencyImmune dysregulation
The application discloses CpG-containing oligodeoxynucleotide (ODN) with the function of regulating the body's immune capacity and application thereof. The oligodeoxynucleotide in the application is different from the design concept of traditional A-type CpG ODN in sequence and structure, embodies the complex drug-making rule and overcomes the problem of traditional A-type CPG in drug-making. The oligodeoxynucleotide has excellent activity of regulating the body's immune function in vitro and in vivo, can stimulate the production of I, II and III type interferons, regulates the Th1 type immune response, and inhibits the Th2 type and Th17 type inflammatory response. Therefore, the oligodeoxynucleotide can prevent and treat allergic diseases caused by Th2 type immune response, including allergic rhinitis, atopic dermatitis, asthma, chronic obstructive pulmonary disease, eosinophil and Th17 related diseases, can prevent and treat the infection and spread of respiratory or non-respiratory pathogenic microorganisms including viruses, bacteria, fungi and parasites, can improve the immune level of the elderly and immunodeficient population, can convert "cold tumor" into "hot tumor", improve the effect of cancer immunotherapy, can prevent and treat central nervous system diseases related to immune dysfunction such as Alzheimer's disease, and can be applied to other diseases related to immune dysfunction.
Owner:NANJING JSIAMA BIOPHARMACEUTICALS LTD
Hemoglobin-related gene for diagnosing immune status and use thereof
PCT designated stageWO2026005512A1Microbiological testing/measurementBiological testingImmunodeficiencyRelated gene
The present invention relates to a composition for diagnosing immunodeficiency or a method for providing information for diagnosis thereof. By using the composition and the method according to one aspect, it is possible to simply and effectively diagnose immune-deficient conditions such as immunosuppression or immune paralysis.
Owner:SUNG KWANG MEDICAL FOUND
AAVR knockout mouse in combination with human liver chimerism and methods of use and production of the same
PendingUS20260007122A1Compounds screening/testingCell receptors/surface-antigens/surface-determinantsImmune compromisedKnockout animal
The present disclosure provides an immunodeficient or immune-impaired chimeric non-human animal with a deletion or impairment of adeno-associated virus receptor (AAVR), comprising human hepatocytes, methods for preparing the chimeric non-human animal comprising human hepatocytes and methods of utilizing the chimeric non-human animal comprising human hepatocytes to evaluate transduction efficiency of adeno-associated viruses (AAV), and determine mechanism of inhibition / modification of AAV transduction in human hepatocytes.
Owner:AVACHROME INC
Method of induction of immune cells into a memory-like state
PCT designated stageWO2025166096A1Genetically modified cellsBlood/immune system cellsAutoimmune conditionLymphocyte
The present invention pertains to the field of cellular immunotherapy. More precisely, it is directed to therapeutic interventions against cancer, immunodeficiency, infectious diseases, and autoimmune conditions utilizing human memory-like cytotoxic lymphocytes, including T cells, Natural Killer (NK) cells, Natural Killer T (NKT) cells, monocytes and other relevant cell types. Disclosed are methods for the isolation and induction of these cells into a memory-like state, which can find application in therapeutic contexts as well as in non-therapeutic contexts, such as in research endeavors.
Owner:INNDURA THERAPEUTICS INC
Borylated amino acid compositions for use in boron neutron capture therapy and methods thereof
PendingJP2026010043AInorganic boron active ingredientsEnergy modified materialsNeutron captureImmunodeficiency
To provide new and improved methods of treating cancer, immune disorders, and other diseases utilizing borylated amino acids and neutron capture therapy (NCT).SOLUTION: Disclosed herein are borylated amino acid ("BAA") compositions and methods of making BAAs. Accordingly, BAAs can be administered to patients as neutron capture agents and can provide methods of treating cancer, immune disorders, and other diseases by utilizing neutron capture therapy modalities. The invention described herein relates to the field of boron neutron capture therapy (BNCT). In particular, the present invention relates to borylated amino acid ("BAA") or ("BAAs") compositions that can be used as a vehicle for neutron capture therapy in humans. The invention further relates to the treatment of cancer and other immune disorders and diseases.SELECTED DRAWING: None
Owner:TAE LIFE SCIENCES LLC
Non-human autoimmune disease model animal, myositis model animal, method for producing same, and use thereof
PCT designated stageWO2025258683A1Microbiological testing/measurementBlood/immune system cellsImmunologic disordersPeripheral blood mononuclear cell
Provided is a non-human autoimmune disease model animal derived from an immunodeficient non-human animal as a pathologic model animal in which symptoms of an autoimmune disease are more faithfully reproduced, wherein peripheral blood mononuclear cells (PBMCs) derived from a heterologous animal subjected to CD8-positive T cell removal treatment are transfected, and symptoms of an autoimmune disease are exhibited.
Owner:TANABE PHARMA CORP
Novel latilactobacillus curvatus strain having immunoenhancing efficacy and immunoenhancing composition comprising same
PCT designated stageWO2026075443A1BacteriaAnimal feeding stuffPhosphorylationNatural Killer Cell Inhibitory Receptors
The present invention relates to a novel Latilactobacillus curvatus strain WiKim0169 having immunoenhancing efficacy, and an immunoenhancing composition comprising same. In the present invention, it was found that the Latilactobacillus curvatus strain WiKim0169, which is a novel kimchi-derived strain, significantly increases splenic NK cell activity and increases the production of inflammatory mediators, immunoglobulins, and cytokines, thereby alleviating immunosuppressive responses. In addition, it was confirmed that the Latilactobacillus curvatus strain WiKim0169 has an effect of alleviating immune dysfunction by increasing the mRNA expression levels of iNOS, COX2, TNF-α, IL-1β, IL-6, IL-2, IL-12, and IL-10 in splenic tissue and increasing the phosphorylation levels of NF-κB and IκBα. Therefore, according to the present invention, the composition comprising the Latilactobacillus curvatus strain WiKim0169, which is a novel kimchi-derived strain, as an active ingredient is expected to be usefully employed as a pharmaceutical and functional food composition for immunoenhancement.
Owner:PHARMSVILLE
Tgfbeta signal convertor
The present disclosure provides improved compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Owner:REGENERON PHARMACEUTICALS INC
Anti-CD28 antibody and use thereof
Provided are an anti-CD28 antibody or an antigen-binding fragment thereof, and a multi-specific antibody constructed on the basis of the antibody or the antigen-binding fragment thereof. The multi-specific antibody comprises an anti-CD3×CD28 bispecific antibody and an anti-tumor-associated antigen (TAA)×CD3×CD28 trispecific antibody. Further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a vector and a cell comprising the nucleic acid molecule, a pharmaceutical composition comprising the antibody or the antigen-binding fragment thereof, and the use of the antibody or the antigen-binding fragment thereof, in particular for the treatment of tumors or immunodeficiency diseases.
Owner:CYTOCARES (SHANGHAI) INC
Mouse gastric adenocarcinoma cell line MPC as well as construction method and application thereof
PendingCN120442547AMicrobiological testing/measurementMicroorganism based processesCancer cellMouse tumor
The invention discloses a mouse gastric adenocarcinoma cell line MPC as well as a construction method and application thereof, and belongs to the technical field of preparation of tumor cell lines and tumor models. The mouse gastric adenocarcinoma cell strain MPC is preserved in China Center for Type Culture Collection, has Cdh1 and Tp53 gene mutations at the same time, has stable cell biological characteristics and typical adenocarcinoma characteristics, can form tumors in immunodeficient and normal immune mice, can be used for preparing a mouse tumor model for occurrence, development and metastasis of gastric cancer, and has a good application prospect. The method is applied to important researches such as molecular biology, cytobiology, detection kit development, new drug research and development and the like.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating myelodysplastic syndrome
The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for preventing or treating myelodysplastic syndrome and related complications thereof. The traditional Chinese medicine composition comprises sculellaria barbata, astragalus membranaceus, angelica sinensis, nightshade, radix curcumae, red ginseng, duchesnea indica, saussurea involucrata, cyclea verticillata and salvia miltiorrhiza. The traditional Chinese medicine composition has a good prevention and treatment effect on myelodysplastic syndrome and related complications thereof, can effectively inhibit proliferation of hematological tumor cells, and also can inhibit proliferation of the myelodysplastic syndrome by increasing the hemoglobin level, reducing the inflammatory cytokine level and reducing the proportion of peripheral blood T cells. Anemia, inflammation and low immune function caused by the myelodysplastic syndrome can be treated. The invention provides an effective strategy for prevention or treatment of myelodysplastic syndrome and related complications thereof, and provides a new direction for application of the traditional Chinese medicine composition.
Owner:GUIYANG XINTIAN PHARMA CO LTD +1
Engineered T cells
The present disclosure provides improved compositions for adoptive T cell therapy for treating, preventing, or ameliorating at least one symptom of cancer, infectious diseases, autoimmune diseases, inflammatory diseases, and immunodeficiency, or conditions associated therewith.
Owner:GENE MEDICAL IMMUNOTHERAPY LLC +1
Fusion protein of Anti-tigit antibody and il2 or variant thereof, and application thereof
PendingUS20250333507A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntiendomysial antibodiesAntigen Binding Fragment
Provided are a fusion protein of an anti-TIGIT antibody and IL2 or a variant thereof, and an application thereof. Specifically, a fusion protein is provided, which comprises: (a) a first polypeptide comprising an anti-TIGIT antibody or an antigen-binding fragment thereof; and (b) a second polypeptide comprising interleukin-2 (IL-2) or a variant thereof having a lymphocyte growth promoting activity, the second polypeptide being fused to the first polypeptide. Also provided are an application of such a fusion protein in positively regulating immune cell activity and / or improving immune responses; and / or, an application thereof in the treatment of cancer, immunodeficiency or inflammatory diseases, or infectious diseases.
Owner:SHANGHAI CELGEN BIO PHARMA CO LTD
Application of Lactobacillus rhamnosus fermented ginseng freeze-dried powder in the preparation of immunomodulatory drugs
This invention discloses the application of *Lactobacillus rhamnosus*-fermented ginseng freeze-dried powder in the preparation of immunomodulatory drugs, belonging to the field of bio-fermentation and immunomodulation technology. The *Lactobacillus rhamnosus*-fermented ginseng freeze-dried powder is prepared by fermenting ginseng with *Lactobacillus rhamnosus*. The rare ginsenosides include at least one of Ck, Rk1, Rh4, and Rg5. The immunomodulatory drug is used to improve cyclophosphamide-induced immunodeficiency. The amount of *Lactobacillus rhamnosus*-fermented ginseng freeze-dried powder added to the immunomodulatory drug is 10%-50% (mass fraction). The preparation method of the *Lactobacillus rhamnosus*-fermented ginseng freeze-dried powder is as follows: S1, ginseng pretreatment; S2, strain activation; S3, fermentation culture; S4, freeze-dried powder preparation. This invention has the technical effects of high bioavailability of ginseng active ingredients, significant immunomodulatory effect, good safety, and effective improvement of cyclophosphamide-induced immunodeficiency.
Owner:JILIN AGRI SCI & TECH COLLEGE
Camptothecin analogs, conjugates, and methods of use
Camptothecin analogs of formula (I), (II), (III) are described, as well as conjugates comprising these camptothecin analogs. These camptothecin analogs and conjugates are useful as therapeutic agents, particularly for the treatment of cancer, infectious diseases, inflammatory diseases, autoimmune diseases, and immunodeficiency diseases.
Owner:NONA BIOSCIENCES (SUZHOU) CO LTD
Culture method of immunodeficient nude mice
The invention relates to the technical field of experimental animal culture, and discloses an immunodeficient nude mouse culture method, which comprises a genotype early-stage identification step based on the morphological characteristics of newborn suckling mouse beards, and specifically comprises the following steps: observing the beards in the mandibular and perinasal areas of a suckling mouse within 12 hours after the suckling mouse is born; if the number of the beards is less than 10, the length is less than 0.5 mm, the beards are curled and hair follicles are sparsely distributed, judging that the beards are homozygotes (nu / nu); if the number is larger than 20, the length is larger than or equal to 1.2 mm, and the seeds grow vertically and are arranged tightly, the seeds are judged to be heterozygotes (n < u / + >). According to the culture method of the immunodeficient nude mice, early-stage accurate screening and efficient culture of the homozygous nude mice can be realized through fine identification of beard forms of newborn suckling mice and milk replacement management of heterozygous breeding mice.
Owner:ZHEJIANG VITAL RIVER LAB ANIMAL TECH CO LTD
CD33 targeted immunotherapies
The present disclosure provides improved CD33 targeting polypeptides and compositions for adoptive T cell therapies for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Owner:REGENERON PHARMACEUTICALS INC +1
2-amino-4-methylquinazoline compounds, processes for their preparation, uses and pharmaceutical compositions
This invention relates to 2-amino-4-methylquinazoline compounds, their preparation methods, uses, and pharmaceutical compositions. Specifically, it provides a compound represented by Formula I, which is a phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor that can be used to prevent and / or treat diseases related to PI3Kδ activity, such as tumors, autoimmune diseases, immunodeficiency diseases, inflammation, kidney diseases, cardiovascular diseases, metabolic / endocrine disorders, or neurological diseases.
Owner:INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
Multipartite receptor and signaling complexes
PendingUS20250312451A1Peptide/protein ingredientsAntibody mimetics/scaffoldsAntigenAutoimmune condition
The present disclosure provides adoptive T cell therapies that have improved architectures for targeting antigens and recruiting multimeric immune signaling complexes for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.
Owner:REGENERON PHARMACEUTICALS INC
Dosage forms for local injection containing eltrombopag for use in treating degenerative diseases and improving stem cell homing - Patent Application 20070122999
PendingJP2025542310APowder deliveryOrganic active ingredientsImmunologic disordersAutoimmune condition
The present invention relates to a controlled-release pharmaceutical composition comprising at least a controlled-release pharmaceutical dosage form containing EPAG, the controlled-release pharmaceutical composition being suitable for local injection into an affected area. The present invention also relates to a controlled-release pharmaceutical composition in powder form for preparing the pharmaceutical composition suitable for local injection, and a kit for preparing the pharmaceutical composition comprising an aqueous injection vehicle and a controlled-release dosage form or a mixture of controlled and immediate-release dosage forms containing EPAG, the pharmaceutical composition optionally including an excipient. The composition is useful for local injection in patients to improve stem cell homing and / or treat non-malignant hematological disorders, malignant hematological diseases, primary immunodeficiencies, autoimmune diseases, inborn errors of metabolism, and / or degenerative diseases / injuries.
Owner:PK MED SAS
Method for constructing immunodeficient Chinese hamster by knocking out Prkdc gene based on CRISPR / Cas9 technology
The invention relates to the technical field of transgenosis, in particular to a method for knockout of a Prkdc gene based on a CRISPR / Cas9 technology to construct an immunodeficient Chinese hamster. According to the invention, the CDS region of the Chinese hamster Prkdc gene is knocked out by utilizing a CRISPR / Cas9 technology, gRNA for targeted knockout of the Chinese hamster Prkdc gene is provided, and the application of a gene editing technology in the Chinese hamster is widened. The method for constructing the Prkdc gene knockout Chinese hamster animal model by using the CRISPR / Cas9 system has the advantages of high accuracy, simplicity, feasibility and short period, and provides service for research on immunodeficiency animal models and pathogenesis of human tumor diseases. The invention detects that the expression of T and B lymphocytes is reduced, which indicates that the Chinese hamster immunodeficiency animal model is successfully prepared. The application range of the Chinese hamster is widened, and a new species is provided for an immunodeficiency animal model.
Owner:SHANXI MEDICAL UNIV
Embryo-like model and construction method and application thereof
The invention provides a construction method of an embryo-like model, which comprises the following steps: culturing primitive state stem cells in vitro or injecting the primitive state stem cells into an immunodeficient animal body for differentiation to obtain the embryo-like model. According to the method, in the process of preparing the embryo-like model, cell factors and small molecular pathway interference factors do not need to be added, gene editing is not needed, only a single starting cell type is adopted, and the method has the advantages of being simple and high in repeatability, facilitates large-scale preparation and application, and has wide application prospects. And the prepared embryo-like model has all embryo external cell lineages and all embryo internal cell lineages except for trophoderm, and can simulate the development process from an implanted embryo of a Carbonate-resistant group 3 stage to a Carbonate-resistant group 9 stage nerve embryo, so that the embryo-like model can be used for preparing various progenitor cell lineages, modeling diseases, screening drugs and carrying out scientific research.
Owner:SHENZHEN HUADA GENE INST +1