2033 results about "Suppressor" patented technology

A sound suppressor for a firearm comprises a cylindrical housing having a rear end cap attached to the housing and having means for mounting to the muzzle of a firearm, a front end cap attached to the housing and having a centrally positioned aperture, and at least one baffle element positioned within the housing between the rear end cap and front end cap. The baffle element comprises a flat plate with an integral rearward-protruding cone with the cone having an entrance aperture and an exit aperture, with the cone having an elongated aperture that extends from the entrance aperture toward the flat plate. An initial coaxial spacer element is positioned between the rear end cap and the baffle element, with the initial coaxial spacer element having at least one gas port and at least one notch at an edge of the initial coaxial spacer element. Inner and outer expansion chambers are formed between the rear end cap, the initial coaxial spacer element and the baffle element. A coaxial spacer element is positioned between the front end cap and the baffle element, and the coaxial spacer element has at least one gas port and at least one notch at an edge of the coaxial spacer element. Inner and outer expansion chambers are formed between the baffle element, the coaxial spacer element and the front end cap.

A radome adapted to reduce backlobes of an associated reflector antenna via application of a conductive ring with an inward facing edge about the periphery of the radome. The conductive ring may be applied extending around the radome periphery to an inside and or outside surface of the radome. The conductive ring may be formed upon the radome by metalising, electrodaging, over molding or the like. Further, the conductive ring may be a metal, metallic foil, conductive foam or the like which is coupled to the radome. An absorber in the form of a ring or a surface coating applied to the radome and or the distal end of the reflector may also be added between the radome and the reflector.

This invention relates to a method for prevention and treatment of aging, age-related disorders and / or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, type 2 diabetes, dementia and some forms of arthritis and cancer in a subject comprising administering to said subject, separately, sequentially or simultaneously a therapeutically effective dosage of each component or combination of statins, bisphosphonates, cholesterol lowering agents or techniques, interleukin-6 inhibitor / antibody, interleukin-6 receptor inhibitor / antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor / antibody, tyrosine kinases inhibitors / antibodies, serine / threonine kinases inhibitors / antibodies, mitogen-activated protein (MAP) kinase inhibitors / antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors / antibodies, Nuclear factor κB (NF-κB) inhibitors / antibodies, IκB kinase (IKK) inhibitors / antibodies, activator protein-1 (AP-1) inhibitors / antibodies, STAT transcription factors inhibitors / antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof, administered separately, in sequence or simultaneously. Inhibition of the signal transduction pathway for Interleukin 6 mediated inflammation is key to the prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, aging, age-related disorders and / or age-related manifestations including osteoporosis, type 2 diabetes, dementia and some forms of arthritis and tumors. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway utilizing interleukin-6 inhibitor / antibody, interleukin-6 receptor inhibitor / antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor / antibody, tyrosine kinases inhibitors / antibodies, serine / threonine kinases inhibitors / antibodies, mitogen-activated protein (MAP) kinase inhibitors / antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors / antibodies, Nuclear factor κB (NF-κB) inhibitors / antibodies, IκB kinase (IKK) inhibitors / antibodies, activator protein-1 (AP-1) inhibitors / antibodies, STAT transcription factors inhibitors / antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism, isoprenoid depletion and / or inhibition of the signal transduction pathway

The present invention provides a power regulation system and method with high speed signal settling capabilities for providing rapid active transient response to a microelectronic device. An active transient response system includes a power supply configured to receive external and / or internal signals indicating the occurrence of transient load conditions and to respond to the transient load conditions based on one or more of these signals. The system may further include a transient suppressor configured for early detection of transients, assisting in transient suppression, and early signaling of transient activity to the power supply.The system provides rapid recovery to steady state operation from the active transient response mode by using a digital compensator to quickly modifying the duty cycle and provide a voltage offset proportional to the transient microprocessor load step. Recovery is further improved by current rephasing techniques.

This invention relates to a method for prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, type 2 diabetes, dementia and some forms of arthritis and cancer in a subject comprising administering to said subject, separately, sequentially or simultaneously a therapeutically effective dosage of each component or combination of statins, bisphosphonates, cholesterol lowering agents or techniques, interleukin-6 inhibitor / antibody, interleukin-6 receptor inhibitor / antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor / antibody, tyrosine kinases inhibitors / antibodies, serine / threonine kinases inhibitors / antibodies, mitogen-activated protein (MAP) kinase inhibitors / antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors / antibodies, Nuclear factor κB (NF-κB) inhibitors / antibodies, IκB kinase (IKK) inhibitors / antibodies, activator protein-1 (AP-1) inhibitors / antibodies, STAT transcription factors inhibitors / antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof, administered separately, in sequence or simultaneously. Inhibition of the signal transduction pathway for Interleukin 6 mediated inflammation is key to the prevention and treatment of atherosclerosis, peripheral vascular disease, coronary artery disease, aging and age-related disorders including osteoporosis, type 2 diabetes, dementia and some forms of arthritis and tumors. Inhibition of Interleukin 6 mediated inflammation may be achieved indirectly through regulation of endogenous cholesterol synthesis and isoprenoid depletion or by direct inhibition of the signal transduction pathway utilizing interleukin-6 inhibitor / antibody, interleukin-6 receptor inhibitor / antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor / antibody, tyrosine kinases inhibitors / antibodies, serine / threonine kinases inhibitors / antibodies, mitogen-activated protein (MAP) kinase inhibitors / antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors / antibodies, Nuclear factor κB (NF-κB) inhibitors / antibodies, IκB kinase (IKK) inhibitors / antibodies, activator protein-1 (AP-1) inhibitors / antibodies, STAT transcription factors inhibitors / antibodies, altered IL-6, partial peptides of IL-6 or IL-6 receptor, or SOCS (suppressors of cytokine signaling) protein, or a functional fragment thereof. Said method for prevention and treatment of said disorders is based on inhibition of Interleukin-6 inflammation through regulation of cholesterol metabolism, isoprenoid depletion and / or inhibition of the signal transduction pathway.

A sound suppressor for a firearm for reducing sound and flash levels upon the discharge of a firearm comprises a cylindrical housing, a proximal end cap with means for attachment to a firearm and to the cylindrical housing, a distal end cap with means for attachment to the housing, and a plurality of baffles positioned within the housing and between the proximal end and distal end caps of the suppressor. A separate cylindrical spacer element is positioned between the proximal end cap of the suppressor and the first baffle. This spacer provides axial positioning of the baffles within the cylindrical housing of the suppressor. The distal end cap of the suppressor is provided with a concentric circular hole or aperture for the projectile to pass through the end of the suppressor. In a number of preferred embodiments, the sound suppressor utilizes baffles that use two or more of the disclosed features that enhance reduction of sound and flash, these features being a rearward conical protrusion provided with multi-annular steps, a flange with an external diameter slightly less than the internal diameter of the cylindrical housing, a frontal turbulence generation structure, a frontal turbulence generation structure provided with at least one cut-out, a turbulence generation structure, and gas cross-flow enhancement cuts positioned on the proximal and distal sides of the baffles.

A suppressor for use with a firearm having a barrel with a muzzle and a bore, the suppressor includes an outer casing having a rearward end and a forward end, an evacuator assembly for receiving the muzzle of the firearm carried by the outer casing, and an expansion chamber defined between the outer casing and the evacuator assembly in gaseous communication with an interior volume of the evacuator assembly.

The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible tumor suppressor mir-302 agent into mammalian cells. More particularly, the present invention relates to a method and composition for generating a Tet-On / Off recombinant transgene capable of expressing a manually re-designed mir-302 microRNA (miRNA) / shRNA agent under the control of doxycyclin (Dox) in human somatic / cancer cells and thus inducing certain specific gene silencing effects on the differentiation-associated genes and oncogenes of the cells, resulting in reprogramming the cells into an ES-like pluripotent state.

An electromagnetic noise suppressor of the present invention includes a base material 2 containing a binding agent and a composite layer 3 formed by integrating the binding agent that is a part of the base material 2 and the magnetic material. This electromagnetic noise suppressor has high electromagnetic noise suppressing effect in the sub-microwave band, and enables it to reduce the space requirement and weight. The electromagnetic noise suppressor can be manufactured by forming the composite layer 3 on the surface of the base material 2 by physical vapor deposition of the magnetic material onto the surface of the base material 2. The article with an electromagnetic noise suppressing function of the present invention is an electronic component, a printed wiring board, a semiconductor integrated circuit or other article of which at least a part of the surface is covered by the electromagnetic noise suppressor of the present invention.

In order to form a noise suppressor in a hose of e.g. a motor vehicle, modular portions are connected in series to define suppression chambers with particular noise suppression characteristics. Those characteristics are due to the volume of each chamber, to the size of the apertures from the chambers to the central duct of the suppressor, and optionally due to spacers which are inserted into at least one aperture of the chambers to alter the effective open area of that aperture. Such spacers may also be used in which the noise suppressor is not modular. Where modular portions are used, it is preferable that each chamber is bounded by parts of two modular portions. A wall of one modular portion may then close the chamber in another modular portion, making the manufacture of the modular portions easier. Also disclosed is the use of a mass acting as a damper, which may be a noise suppressor as previously discussed, within a hose. The mass is connected to the hose by resilient means, e.g. electrometric material.

Speech-free noise estimation by cancellation of speech content from an audio input where the speech content is estimated by noise suppression. Adaptive noise cancellation with primary and noise-reference inputs and an adaptive noise cancellation filter from estimating primary noise from noise-reference input. Speech Suppressor (Noise Estimation) applied to noise-reference input provides speech-free noise estimates for noise cancellation in the primary input.

A gas-operated firearm has a barrel defining a bore with a gas block defining a chamber communicating with the bore via a gas passage. A gas regulation element has a first position and a second position, and serves to provide different gas flow characteristics in the different positions. The latch element gives the user audible or tactile feedback upon installation of an accessory device when the gas regulation element is a correct position suited to use of the accessory, and not when in the other position unsuited to accessory usage. The accessory may be a sound suppressor, and the latch may serve to secure the gas regulation element against position change. The latch may engage a circular array of elements on the rear face of the suppressor, and may have an angled cam face to provide ratcheting engagement for installation, and to resist removal or loosening without deliberate actuation of the latch.

A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.

An electromagnetic interference suppressor of substantially unpressurized sheet form is obtained by applying and drying a magnetic paint, and comprises 30 to 80% by volume of soft magnetic powder and 20 to 70% by volume of a binder. The binder is an elastomer or a resin that a glass transition point and / or a softening point is 50° C. or more and a storage modulus (E′) is 107 Pa (JIS K 7244-1) or more in a state containing neither solvent nor filler at room temperature. This electromagnetic interference suppressor exerts a superior electromagnetic interference suppressing effect.

A multi-level floating flame gas fireplace comprises a pair of supporting members, a burner assembly and a plurality of trays. The burner assembly includes a pair of tube members spaced parallel in vertical orientation and is secured between inner portions of each supporting member, a plurality of burners evenly spaced and extended forwardly between the pair of tube members. A plurality of orifices and at least one sound suppressor are provided in the burners to provide even flow or distribution of gas and to reduce noise. Each tray is positioned below each burner and attached between the supporting members. The trays are filled up with a glass media like fire glasses and the burners are covered with the fire glasses. Thus, the structure of the fireplace becomes invisible and when the burners are turned on, the fireplace showcases layers of the floating flames suspended in a stepped back manner.

A suppressor for a firearm includes a first gas expansion section of relatively large size sufficient to reduce the temperature and pressure of the gas expelled from a muzzle during discharge of the firearm to a level that avoids rapid degrading of structural members such as baffles in the suppressor that are downstream of the muzzle. The gas is channeled through multiple paths to distribute its energy more equally. Preferably, the suppressor is formed with a lightweight, thermally-conductive composite portion. The composite portion provides lightweight, bursting strength with good thermal conductivity and little contribution to vibrational instability of the muzzle to which it is attached. The composite portion may be of a carbon fiber, silicon, boron, or metallic base. In one embodiment, a first expansion chamber is in communication with the muzzle and with a second expansion chamber and in another embodiment, the first expansion chamber communicates with the muzzle and with the second expansion chamber The composite portions of the suppressor provide good bursting strength and heat conductivity with light weight. In some embodiments, a series of baffles creates turbulence in the gas, slowing its motion and distributing the energy more evenly over space.

The present invention provides reagents such as cells, cell lines, and vectors, that can be used to identify mammalian genes whose expression products (RNA or protein) play a role in RNA interference (RNAi) and / or to identify chemical modulators of RNAi, or for other purposes. The invention further provides a variety of methods for identifying such genes or modulators. In particular, the invention provides a mammalian cell comprising a nucleic acid that encodes a selectable marker and one or more nucleic acid templates for transcription of an RNAi-inducing agent integrated into the genome of the cell, wherein the RNAi-inducing agent reduces expression of the marker and is not naturally found in the cell. Additional cells and cell lines comprising nucleic acids that encode one or more additional markers are also provided. According to certain of the inventive methods cells such as these are mutagenized, transfected or infected with a library of genetic suppressor elements, or contacted with a test compound. Cells in which RNAi is inhibited or activated are identified using an appropriate selective condition or screening method. The identity of the mutated or inhibited gene or the identity of the compound is then determined.

Methods and compositions which increase the concentration of an inhibitory RNA specific for a target sequence in a cell are provided. In one embodiment, the methods and compositions employ a first polynucleotide comprising a silencing element for a target pest sequence operably linked to a promoter active in the plant cell; and, a second polynucleotide comprising a suppressor enhancer element comprising the target pest sequence or an active fragment or variant thereof operably linked to a promoter active in the plant cell. The combined expression of the silencing element with the target pest sequence, or an active variant or fragment thereof, leads to the amplification of the inhibitory RNA produced from the silencing element over the achievable with only the expression of the silencing element alone. Thus, the various methods and compositions of the invention provide improved methods for the delivery of inhibitory RNA to a target organism.

A sound suppressor suppresses sound and flash by creating interacting paths of gas. While a first portion of the gas follows a first path through the suppressor, a second portion of the gas is diverted radially from the first path to a second path and then repeatedly made to cross the first path by a series of baffles with alternating radial passages so that the two portions of gas interfere and interact with each other, and therefore quickly give up much of their kinetic energy before they exit the suppressor. Preferably, the baffles defining the second path impart a swirl to the second portion of gas to cause the present suppressor to flush itself of carbon and metal particles. The interaction of the two portions also accelerates completion of combustion of the gas to thereby reduce flash.

A compact narrow band interference suppressor. The narrow band interference suppressor includes a plurality of interference signal elimination circuits, a frequency compensation circuit, an AGC amp, and an AD converter that are connected in series. Each interference signal elimination circuit includes a mixer for synthesizing a local oscillation signal of a variable frequency oscillator to eliminate an interference signal with a band elimination filter. The frequency compensation circuit includes a mixer for synthesizing a signal having a frequency generated by the variable frequency oscillator to restore the signal to the frequency band of the signal input to the narrow band interference suppressor by the variable frequency oscillator. The AD converter converts the polarity of the signal in accordance with the number of times the signal passes through the mixer.

A device for suppressing noise from a firearm. In one aspect, the suppressor has an elongate body that defines a bullet pathway extending longitudinally therethrough. The elongate body may define a plurality of adjacent chambers spaced along its longitudinal axis. The suppressor may also have at least two elongate body shells configured to selectively substantially envelop the elongate body and substantially enclose each of the adjacent chambers. The body shells of the suppressor are designed to be easily removed to clean the chambers of the suppressor.

Disclosed are methods for suppressing the induction of inducible nitric oxide synthase in a cell comprising contacting said cell with an effective amount of at least one induction suppressor of inducible nitric oxide synthase or a cytokine are disclosed. The induction suppressor can be an inhibitor of mevalonate synthesis, an inhibitor of the farnesylation of Ras, an antioxidant, an enhancer of intracellular cAMP, an enhancer of protein kinase A (PKA), an inhibitor of NF-kβ activation, an inhibitor of Ras / Raf / MAP kinase pathway, an inhibitor of mevalonate pyrophosphate decarboxylase or an inhibitor of farnesyl pyrophosphate.

A firearm noise suppressor having an internal base frame member with a plurality of inserts mounted thereto. In one form the suppressor is provided with a slip chamber allowing gas to be forwarded to a longitudinally forward chamber for pre-compression of gas therein.

A device for suppressing noise from a firearm. In one aspect, the suppressor has an elongate body that defines a bullet pathway extending longitudinally therethrough. The elongate body may define a plurality of adjacent chambers spaced along its longitudinal axis. The suppressor may also have at least two elongate body shells configured to selectively substantially envelop the elongate body and substantially enclose each of the adjacent chambers. The body shells of the suppressor are designed to be easily removed to clean the chambers of the suppressor.

In one example, a firearm sound suppressor includes a housing including a front end and a rear end. The rear end includes a flange that partially encloses the rear end and defines a rear aperture. The firearm sound suppressor also includes a back end member disposed substantially within the rear end of the housing and including a rear surface disposed in abutment with an inner surface of the flange to prevent the back end member from passing through the rear aperture. Other embodiments are also contemplated.

A noise suppressor device for attaining perceptually preferable noise suppression is disclosed. The device minimizes reduction in quality even in the presence of increased noises. The device is adaptable for use in voice communications systems and speech recognition systems employed in a variety of kinds of noisy environments. The device includes a spectrum subtracter and a spectrum amplitude suppressor that operate on the basis of perceptual weights.

A firearm barrel accessory that quick connects and disconnects to a firearm barrel by rotating is described. The accessory may be a firearm suppressor with a silencer barrel, a mount retention ring located inside the silencer barrel that includes longitudinal grooves that lead to circumferential grooves that have a first radial side and a second radial side. The firearm barrel is attached to a muzzle break that may include a plurality of lugs that fit into longitudinal grooves. After placement in the longitudinal grooves, the silencer barrel and mount retention ring are rotated / twisted about the silencer barrel longitudinal axis so that the circumferential grooves move relative to the lugs until the lugs contact the second radial side, at which point the mount retention ring ceases to rotate while the silencer barrel continues to rotate. A ratchet retention ring may exert tension on the mount retention ring in the rearward direction.