792 results about "Immune system" patented technology

The invention discloses an emergency communication and positioning system and method based on a Beidou satellite. The method comprises the following steps: S1, collecting data in real time; s2, analyzing the emergency state of the user by using a context awareness algorithm; s3, under the condition that the satellite communication signal is stable, transmitting the emergency information to a rescue center according to the calculated priority, if the satellite signal is unstable or interrupted, constructing a self-organizing network, and continuing to transmit the emergency information; s4, dynamically selecting an optimal path based on an adaptive path optimization algorithm inspired by an immune system, and further optimizing path selection through a space-time perception algorithm; s5, according to a priority management mechanism, the emergency information with high priority is processed preferentially, and feedback information is sent; s6, if the first emergency information transmission fails, the system starts a redundant data transmission mechanism; and S7, continuously tracking the state change of the user, and dynamically adjusting the rescue scheme. According to the invention, the situation awareness and immune system optimization algorithm is combined to realize efficient transmission and feedback of emergency information.

The invention relates to the technical field of medical information, in particular to an esophageal cancer multi-mode treatment effect comprehensive evaluation system which comprises a patient data acquisition module, a drug resistance dynamic monitoring and adjusting module, an immune system response dynamic analysis module and a treatment effect evaluation module. The patient data acquisition module is used for acquiring multi-modal health data of a patient; the drug resistance dynamic monitoring and adjusting module analyzes drug resistance signs appearing in the treatment process; the immune system response dynamic analysis module comprehensively evaluates the state change of the immune system; and the treatment effect evaluation module evaluates the treatment effect of the patient in real time based on the drug resistance and immune system response analysis result, and provides treatment adjustment suggestions for the doctor according to the evaluation result. According to the invention, the accuracy of treatment is improved, the risk of treatment failure is reduced, and decision support based on data is provided for doctors.

The invention relates to the technical field of atherosclerosis related drugs, in particular to a macrophage membrane functionalized manganese dioxide nano-drug as well as a preparation method and application thereof in treatment of atherosclerosis. The invention relates to a macrophage membrane functionalized manganese dioxide nano-drug, which comprises an HMnO2 carrier, colchicine is loaded on the HMnO2 carrier, and a macrophage membrane is coated outside the HMnO2 carrier. The preparation can be applied to practical operation of preparing medicines for treating atherosclerosis. According to the technical scheme, the technical problem of limited treatment effect caused by single action mechanism of medicines for treating atherosclerosis in the prior art can be solved. The nano-drug in the scheme can remove ROS to play an anti-inflammatory effect, reprogram macrophages and promote cholesterol excretion, and is used for synergistically treating atherosclerosis. The macrophage membrane can target an inflammation part and escape from an immune system. And the side effect of the nano-drug is relatively small, so that the nano-drug has ideal popularization and application prospects.

The invention discloses a verifiable APT attack chain extraction method based on a cognitive distillation and gating technology. The method comprises the steps of input processing and extraction, dynamic gating weight generation, hierarchical prototype decision making, adversarial robustness guarantee and output. An attack chain time sequence modeling and dynamic gating mechanism is created for the first time, causal constraints are injected through phase perception position coding, semantic fragmentation is avoided through full-word masks, and splitting is conducted in the cracking stage; historical dependence and semantic similarity weight reduction are fused to block noise, and the cutting precision is improved. A cognitive distillation dynamic knowledge evolution system is constructed based on prompt engineering prototype matching and self-attention feature decoupling double engines, so that few-sample reasoning and decision determinacy quantification are realized, technical representation is stripped, a kernel is focused and attacked, and real-time evolution of a knowledge base is promoted; a defense closed loop is constructed by parameterized noise injection and KL divergence, a verifiable countermeasure immune system is established, an attack is simulated to optimize a defense benchmark, probability distribution stability is monitored, the misjudgment rate is extremely low, and a traceable audit log is output.

The invention discloses a plant extract-based bisphenol-free acidic color fixing agent and a preparation method thereof, the color fixing agent adopts natural plant polyphenol as a raw material, the use of bisphenol compounds as a raw material is avoided, and bisphenol substances may induce an oxidative stress system of a human body, disturb an endocrine system and an immune system or cause in-vivo balance disorder, so that the color fixing agent has a good color fixing effect. Even the risk of increasing diabetes and heart disease is caused, and even certain reproductive toxicity is caused. The plant polyphenol compound used for preparing the color fixing agent is non-toxic and harmless, and no toxic substance is left in the color fixing agent finished product. The water-soaking-resistant color fastness and the soaping-resistant color fastness of the bisphenol-free acidic color fixing agent can be both improved to level 3 or above.

Provided is a lipid formulation which is substantially free from cholesterol and which is mixed with nucleic acid to form lipid nucleic acid nanoparticles which are capable of transfecting cells of the immune system in a less destructive manner than electroporation.

Systems and methods for computer modeling in medicine. A sort of period table of medical models is described for personalized diagnostics, prognostics and therapeutics, including at least 80 major categories of medical models. Generative artificial intelligence and geometric deep learning techniques, and algorithms including 2D and 3D graph machine learning and GenAI algorithms, are described, tailored and applied to diagnostic disease description, prognostic prediction and therapeutic development and management, including generation of novel synthetic drugs. The AI and machine learning techniques and algorithms are applied to understand each individual's genetic, RNA and protein anomalies that represent the source of many unique patient diseases. AI-enabled software agents assist physicians and researchers in building patient medical models. Several personalized medicine applications of individualized medical modeling include cardiovascular disease, cancer, neurological disorders, immune system disorders and genetic diseases.

The present application discloses substituted polycyclic heterocycles compound of Formula (I), pharmaceutically acceptable salt and / or solvate and pharmaceutical compositions thereof useful in the treatment of proliferative disease or condition characterized by a dysregulation of the RAS-ERK pathway such as neoplasm disease or disorder, inflammatory disease or immune system disorder.

The invention discloses an establishment method and application of a mouse gastric cancer orthotopic transplantation model, and the establishment method comprises the following steps: injecting a mouse gastric adenocarcinoma cell line MKC1 (Mus musculus) into a mouse gastric tissue, and feeding to obtain the mouse gastric cancer orthotopic transplantation model. Compared with the prior art, the mouse gastric cancer in-situ model established in the invention has the advantages of strong repeatability in the construction process and good passage stability, especially can form tumor subcutaneously in a C57BL / 6 mouse with a sound immune system, has a therapeutic response to immunotherapeutic drugs such as anti-PD-1 monoclonal antibody, and is suitable for research on gastric cancer immune microenvironment and drug resistance mechanism of immunotherapeutic drugs.

The disclosure relates to methods, compositions, and combinations for detoxification in a patient comprising performing therapeutic plasma exchange (TPE) on the patient. The disclosure also relates to methods, compositions, and combinations for removing toxins in a patient as a result of chronic exposure to the toxins, comprising performing one or more TPE sessions on the patient and administering an oral composition to the patient. The methods, compositions, and combinations of the disclosure may also be used to replenish biomarkers indicative of a healthy state of the body in order to improve immune system function or patient longevity, and / or reduce oxidative stress or inflammation. The methods, compositions, and combinations of the disclosure may also be used to reduce the level of atherosclerosis, improve cognitive function, prevent early cancer development, promote immune health, and / or treat health conditions or diseases such as autoimmune diseases, cancers, Alzheimer's disease, Parkinson's disease, chronic fatigue syndromes, or fibromyalgia. Additionally, the methods, compositions, and combinations of the disclosure may comprise an intravenous supplementation, wherein each TPE session is followed by administration to the patient of an IV composition. The disclosure further relates to oral compositions and IV compositions for use in the methods, compositions, and combinations of the disclosure.

The invention relates to the technical field of psychosomatic health management, in particular to a psychological immune system evaluation system and intervention method for cancer patients. And the data acquisition module is used for acquiring and fusing the immune biochemical indexes of the patient, the continuous physiological time sequence signals generated by the wearable device, the digital psychological assessment data and the clinical treatment stage marks, and outputting a structured multi-dimensional time sequence data set through time alignment and feature extraction operation. Through multi-modal data fusion and integrated machine learning analysis, the psychosomatic health risk of the patient can be predicted based on the continuous physiological and psychological data change trend of the patient, and corresponding intervention measures can be triggered before the patient has obvious clinical symptoms by outputting the quantized risk coefficient and the multi-stage early warning signal, so that the accuracy of the patient is improved. Therefore, an intervention mode is promoted to be converted from traditional intervention after evaluation to predictive and preventive intervention.

The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).

Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and / or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and / or activate or increase circulation of one or more immune cells (such as natural killer cells and / or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.

The invention provides an anti-cancer active component optimization method for breast cancer treatment, which comprises the following steps: analyzing a potential interference path of an anti-cancer active component on immune system cell viability by adopting a computational chemistry simulation method according to a preliminary structural function mapping relationship, and determining a specific molecular mechanism range of immune system weakening; according to the synergistic effect evaluation result, optimizing the structural parameters of the active components through a molecular docking algorithm, adjusting the binding affinity of the active components with tumor cell targets and pathogenic bacteria targets, and determining a final structural optimization scheme; aiming at the final structure optimization scheme, verifying the expression of the modified active component on tumor inhibition and antibacterial ability by adopting simulation data of an in-vitro activity test, and obtaining a verification data set of comprehensive performance; and aiming at the updated active component design data, through a multi-objective optimization model, balancing the synergism of an anti-cancer effect and a health protection mechanism, and determining a final compound structure configuration suitable for complex requirements of a clinical environment.

The invention discloses a recurrence-resistant cell strain for colorectal cancer large segmentation radiotherapy and application, and relates to the technical field of cell biology. The colorectal cancer large segmentation radiotherapy recurrence-resistant cell strain is preserved in the China Center for Type Culture Collection on January 2, 2025, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: C202533. By constructing the colorectal cancer large segmentation radiotherapy recurrence-resistant cell strain, a new biological material is provided for studying the radiotherapy recurrence-resistant colorectal cancer. The cell strain is screened in a mouse body with a sound immune system, has better physiological correlation, and is beneficial to research on the influence of an immune microenvironment on tumor cell radiotherapy resistance and the remodeling effect of radiotherapy resistant cells on the immune microenvironment. The cell strain can also monitor tumor recurrence after radiotherapy in real time through fluorescence imaging.

The invention discloses a mouse-derived gastric adenocarcinoma cell line MKC1 and application thereof. The mouse gastric adenocarcinoma cell line MKC1 (Mus musculus) is preserved in the China Center for Type Culture Collection, the preservation date is June 15, 2024, and the preservation number is CCTCC (China Center for Type Culture Collection) NO: C2024183. The cell line belongs to a murine gastric adenocarcinoma cell line, can be stably passaged, is high in growth speed, and can form primary tumors in a C57BL / 6 mouse body with a sound immune system. In addition, the cell line has the advantages of being high in repeatability, stable and single in property and the like, and is suitable for related research of gastric cancer immune microenvironment, tumor drug resistance, invasion and metastasis and the like.

The invention provides a plant lactobacillus IOB602 for improving the protection mechanism of retinal cells under blue light and application of the plant lactobacillus IOB602, and relates to the technical field of microorganisms. The lactobacillus plantarum is classified and named as lactobacillus plantarum, and the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) No.16021. The strain improves the activity of retinal epithelial cells, reduces the content of cell proinflammatory factors IL-6, IL-1beta and TNF-alpha, relieves inflammation, is beneficial to recovery of the expression of antioxidant enzymes, and effectively improves macular region edema by reducing the content of vascular endothelial growth factors; the activity of catalase, superoxide dismutase and glutathione peroxidase is improved; the content of proinflammatory factors IL-6, IL-1beta and TNF-alpha in mouse serum is reduced, and the immune system of a body is regulated, so that the protection mechanism of retinal cells in a blue light environment is improved.

The invention relates to the field of 26S proteasome inhibition and modulation by niclosamide and to a method for treating diseases related to increased proliferation, immune system, inflammation and neurodegenerative disorders by inhibition and modulation of the 26S proteasome in living cells, and to a niclosamide-containing compound for use in this treatment.

The invention belongs to the technical field of disease drugs, and particularly relates to application of an engineered attenuated coxsackie B3 virus vector (CVB3 (mu)) in preparation of drugs for treating traumatic craniocerebral injury. According to the application disclosed by the invention, after severe craniocerebral injury of a mouse, CVB3 (mu) can remodel a host immune system through single intraperitoneal injection treatment, so that the absorption speed of encephaledema on an affected side can be remarkably increased, and the effect of treating traumatic craniocerebral injury is achieved; in addition, the CVB3 (mu) has remarkable safety.

The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).

The invention belongs to the technical field of disease drugs, and particularly relates to application of a recombinant attenuated coxsackie B3 virus loaded with an anti-inflammatory factor in preparation of drugs for treating traumatic craniocerebral injury. The virus can regulate and control a peripheral immune phenotype capable of inhibiting inflammation, after severe craniocerebral injury of a mouse, a host immune system is remodeled through single intraperitoneal injection treatment, a treatment effect is achieved in improving an immune microenvironment in the acute stage of TBI, the neuroprotective effect is observed in the early stage and the late stage of TBI, and safety is achieved.

The invention relates to a pyrimidopyrrole derivative and application thereof in medicine, in particular to a compound shown in a general formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or a co-crystal of the compound, an intermediate and a preparation method of the compound, and application of the compound in BTK related diseases such as tumors or autoimmune system diseases. # imgabs0 #

The invention discloses an arabidopsis thaliana RK3 gene and application of S structural domain receptor kinase RK3 coded by the arabidopsis thaliana RK3 gene in improvement of plant disease resistance, and belongs to the technical field of plant genetic engineering. According to the application of the arabidopsis thaliana RK3 gene to improvement of plant disease resistance, the nucleotide sequence of the arabidopsis thaliana RK3 gene is shown as SEQ ID NO.1, the amino acid sequence of S structural domain receptor kinase RK3 coded by the arabidopsis thaliana RK3 gene is shown as SEQ ID NO.2, and further plants are selected from arabidopsis thaliana, oilseed rape, rice, tomatoes, potatoes, peanuts, soybeans, cotton, tobacco, cucumbers, watermelons and the like. The expression of the plant disease resistance comprises infection resistance to wild-type pseudomonas syringae, effector engineering strains thereof and botrytis cinerea. It is clear that the arabidopsis thaliana RK3 gene and the encoded protein thereof can remarkably enhance the infection resistance of plants to various pathogenic bacteria for the first time, disease prevention and control are achieved by activating the autoimmune system of the plants, and an effective path is provided for reducing chemical pesticide application and promoting agricultural green development.

The invention relates to the technical field of conditioners, in particular to a conditioner for improving crop stress resistance and a preparation method thereof, and the conditioner comprises the following raw materials: plant hormones, trehalose, humic acid, a complex microbial inoculant, modified nano sodium alginate, modified nano zinc oxide, lactic acid, a green tea extract and a licorice extract. The modified nano-sodium alginate, the modified nano-zinc oxide and the lactic acid play a role through a synergistic effect, the modified nano-sodium alginate and nutrient substances form a modified nano-sodium alginate gel compound through physical adsorption and chemical effects, stress-resistant peptides on the surface of the compound directly activate immune systems of crops, synthesis of stress-resistant proteins is promoted, and the stress resistance of the crops is improved. The modified nano-zinc oxide enhances the absorption of nutrient substances by crop root cells, assists the activation of crop immune systems, and synergistically enhances the disease resistance and stress resistance of crops, and the lactic acid effectively stabilizes the pH value of the conditioner, relieves the oxidation pressure of crops under adverse conditions, and enhances the physiological stability of crops.

The invention relates to the field of animal consumer goods, and particularly discloses application of glucan in preparation of animal products for relieving pet stress syndromes. Pet experiments find that beta-1, 3 / alpha-1, 3-glucan can improve the stress syndromes of the indoor cats, specifically, abnormal behaviors of the cats are corrected, and abnormity of multiple systems of organisms such as the immune system, the endocrine system and the urinary system is improved. And when the method is applied to pets, the life quality of the pets can be remarkably improved, more emotional support is provided for pet owners, and the method has practical popularization and application values.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

The invention relates to the technical field of biology, in particular to a tumor postoperative vaccine as well as a preparation method and application thereof. The method comprises the following steps: resuspending tumor cells in a first solution containing metal ions for incubation, collecting the tumor cells, resuspending the tumor cells in a second solution containing mineralized ions for incubation, enabling the metal ions to react with the mineralized ions to obtain metal inorganic salt, forming a mineralized shell layer on the surfaces of the tumor cells, and resuspending the tumor cells to obtain the tumor postoperative vaccine. And due to the mineralized shell layer, the vaccine has the capability of activating a signal channel in an antigen presenting cell through mechanical stimulation, so that an immune system is favorably activated, and the anti-tumor capability of the vaccine is improved. In addition, tumor cells are inactivated in the vaccine preparation process and keep a complete form, and presentation of a complete tumor antigen is facilitated, so that a relatively good anti-tumor effect is obtained.

The invention relates to the technical field of biological preparations, and discloses an efficient body function repairing active small molecule peptide preparation and a preparation method thereof.The efficient body function repairing active small molecule peptide preparation is prepared from 15-22 parts of collagen peptide, 5-9 parts of glutathione, 10-18 parts of whey protein peptide, 5-8 parts of vitamin C, 2-4 parts of vitamin E, 1-3 parts of zinc element, 5-15 parts of astragalus membranaceus extract, 3-8 parts of probiotics and 10-20 parts of a delivery carrier. The molecular weight range of the original protein peptide, the glutathione and the whey protein peptide is 500 to 2000Da. According to the invention, collagen peptide, glutathione, whey protein peptide, vitamins and other components are proportioned to realize an anti-oxidation-repair-anti-inflammatory synergistic effect, and vitamin C, vitamin E, zinc element and an astragalus extract are added to cover multi-dimensional repair of an immune system, so that comprehensive body function repair is realized.

The present invention provides a site-directed mutated influenza virus gene non-coding region nucleic acid fragment and its application in improving the expression efficiency of mRNA vaccines. The provided site-directed mutated influenza virus gene non-coding region nucleic acid fragment has a sequence of SEQ ID NO: 3. The present invention also provides an mRNA fragment for translating and expressing in a host, which contains a coding frame for encoding a target protein, and the 5′UTR and / or 3′UTR of the mRNA fragment is the site-directed mutated influenza virus gene non-coding region nucleic acid fragment. In view of the problems that the existing mRNA vaccine has low translation efficiency, relatively insufficient activation of the immune system, and difficulty in producing the expected immune protection effect, the present invention provides a method for site-directed mutagenesis of a non-coding region derived from an influenza virus M gene fragment, which can be used as the 5′UTR and / or 3′UTR of the target expression sequence, and can improve the translation efficiency of the target mRNA.

Provided are a method for diagnosing cancer, a diagnosis kit and compositions useful for measurement of NK cell activity. The incidence of cancer may be diagnosed by monitoring changes in the in vivo immune system through measurement of NK cell activity in blood. Thus, the incidence of cancer may be readily predicted as described herein using a blood sample from a subject.