260 results about "Immune system" patented technology

The invention discloses a verifiable APT attack chain extraction method based on a cognitive distillation and gating technology. The method comprises the steps of input processing and extraction, dynamic gating weight generation, hierarchical prototype decision making, adversarial robustness guarantee and output. An attack chain time sequence modeling and dynamic gating mechanism is created for the first time, causal constraints are injected through phase perception position coding, semantic fragmentation is avoided through full-word masks, and splitting is conducted in the cracking stage; historical dependence and semantic similarity weight reduction are fused to block noise, and the cutting precision is improved. A cognitive distillation dynamic knowledge evolution system is constructed based on prompt engineering prototype matching and self-attention feature decoupling double engines, so that few-sample reasoning and decision determinacy quantification are realized, technical representation is stripped, a kernel is focused and attacked, and real-time evolution of a knowledge base is promoted; a defense closed loop is constructed by parameterized noise injection and KL divergence, a verifiable countermeasure immune system is established, an attack is simulated to optimize a defense benchmark, probability distribution stability is monitored, the misjudgment rate is extremely low, and a traceable audit log is output.

The present application discloses substituted polycyclic heterocycles compound of Formula (I), pharmaceutically acceptable salt and / or solvate and pharmaceutical compositions thereof useful in the treatment of proliferative disease or condition characterized by a dysregulation of the RAS-ERK pathway such as neoplasm disease or disorder, inflammatory disease or immune system disorder.

The invention relates to the technical field of psychosomatic health management, in particular to a psychological immune system evaluation system and intervention method for cancer patients. And the data acquisition module is used for acquiring and fusing the immune biochemical indexes of the patient, the continuous physiological time sequence signals generated by the wearable device, the digital psychological assessment data and the clinical treatment stage marks, and outputting a structured multi-dimensional time sequence data set through time alignment and feature extraction operation. Through multi-modal data fusion and integrated machine learning analysis, the psychosomatic health risk of the patient can be predicted based on the continuous physiological and psychological data change trend of the patient, and corresponding intervention measures can be triggered before the patient has obvious clinical symptoms by outputting the quantized risk coefficient and the multi-stage early warning signal, so that the accuracy of the patient is improved. Therefore, an intervention mode is promoted to be converted from traditional intervention after evaluation to predictive and preventive intervention.

The invention discloses an arabidopsis thaliana RK3 gene and application of S structural domain receptor kinase RK3 coded by the arabidopsis thaliana RK3 gene in improvement of plant disease resistance, and belongs to the technical field of plant genetic engineering. According to the application of the arabidopsis thaliana RK3 gene to improvement of plant disease resistance, the nucleotide sequence of the arabidopsis thaliana RK3 gene is shown as SEQ ID NO.1, the amino acid sequence of S structural domain receptor kinase RK3 coded by the arabidopsis thaliana RK3 gene is shown as SEQ ID NO.2, and further plants are selected from arabidopsis thaliana, oilseed rape, rice, tomatoes, potatoes, peanuts, soybeans, cotton, tobacco, cucumbers, watermelons and the like. The expression of the plant disease resistance comprises infection resistance to wild-type pseudomonas syringae, effector engineering strains thereof and botrytis cinerea. It is clear that the arabidopsis thaliana RK3 gene and the encoded protein thereof can remarkably enhance the infection resistance of plants to various pathogenic bacteria for the first time, disease prevention and control are achieved by activating the autoimmune system of the plants, and an effective path is provided for reducing chemical pesticide application and promoting agricultural green development.

The invention relates to the field of animal consumer goods, and particularly discloses application of glucan in preparation of animal products for relieving pet stress syndromes. Pet experiments find that beta-1, 3 / alpha-1, 3-glucan can improve the stress syndromes of the indoor cats, specifically, abnormal behaviors of the cats are corrected, and abnormity of multiple systems of organisms such as the immune system, the endocrine system and the urinary system is improved. And when the method is applied to pets, the life quality of the pets can be remarkably improved, more emotional support is provided for pet owners, and the method has practical popularization and application values.

The invention discloses an EGFR (epidermal growth factor receptor) targeted nano-drug carrier and a preparation method thereof, the EGFR targeted nano-drug carrier comprises drug-loading nanoparticles, an erythrocyte membrane coating the drug-loading nanoparticles and GE11 peptide connected to the erythrocyte membrane, and the drug-loading nanoparticles are formed by connecting tannic acid, ellagic acid and 1, 4-phenyldiboronic acid through boric acid ester bonds. The EGFR targeted nano-drug carrier disclosed by the invention can be enriched at an EGFR overexpressed tumor site in a targeted manner, and can be effectively prevented from being cleared by an immune system, and the drug loaded by the drug-loaded nanoparticles is released in a high-active oxygen environment, so that the treatment effect on tumors can be improved, and the toxic and side effects on normal tissues can be reduced; and photothermal therapy and chemotherapy effects can be simultaneously generated under NIR illumination, and the anticancer efficiency can be remarkably improved through the synergistic effect of the photothermal therapy and the chemotherapy.

Disclosed in the present invention are a biomimetic vascularized iPSC-hep spheroid for liver regeneration, and a preparation method therefor. The biomimetic vascularized iPSC-hep spheroid is a microcapsule with a porous hyaluronic acid methacryloyl as a shell and a human-induced pluripotent stem-cell-derived hepatocyte spheroid as an inner phase, and human umbilical vein endothelial cells adhere to the surface of the shell. The biomimetic vascularized iPSC-hep spheroid of the present invention promotes effective communication between hiPSC-heps and HUVECs, and provides barrier protection for an encapsulated hiPSC-hep spheroid so as to avoid attack by the immune system. Compared with dispersed cells, the cell-to-cell interaction in the cell spheroid improves cell-to-cell communication, helps to simulate the physiological heterogeneous structure and cell microenvironment of the liver, and can more effectively repair an acutely failing liver.

Disclosed are multi-peptide compositions and / or methods of use of the multi-peptide compositions for patients with resected (or definitively treated) high-risk uveal melanoma. Pharmaceutically acceptable embodiments administered to patients may raise an immune system response against uveal melanoma cells, leading to a decrease in uveal melanoma cell number. Further embodiments may take the form of an adjuvant therapy or a neoadjuvant therapy, as monotherapy or in combination with other therapies.

The present disclosure relates to a composition for balancing the immune system of a neonatal or infant subject, the composition comprising an effective amount of 2 '-fucosyllactose, 3-fucosyllactose, 3'-sialyllactose, 6 '-sialyllactose, and lactose-N-tetrasaccharide.

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.

The invention provides cold-pressed food suitable for small dogs and a preparation method of the cold-pressed food, and belongs to the field of dog food. The preparation method of the cold-pressed food suitable for the small dogs comprises the following steps: preparing the composite functional microcapsules, preparing granules, and spraying and forming. According to the preparation method of the cold-pressed food suitable for the small dogs, the calcium-phosphorus ratio can be accurately controlled on the premise of ensuring high calcium, and the cold-pressed food is rich in nutrient substances beneficial to normal development and efficient operation of autoimmune systems, cardiovascular systems and liver and kidney systems of the small dogs; the defects that nutritional ingredients are easy to lose efficacy, the particle hardness matching property is poor and the overall stability is poor in the preparation or storage process can be effectively avoided.

The invention discloses TCN1 (Trancobalamin 1, cobalamin 1) and application of an inhibitor of the TCN1 in preparation of products for diagnosing and treating diseases of an autoimmune system. According to the invention, expression in psoriasis tissues is up-regulated and promoter DNA methylation is down-regulated into genes to screen TCN1 genes, an over-expression TCN1 HaCaT cell line is constructed, and it is verified that the over-expression TCN1 HaCaT cell line participates in keratinocyte proliferation and IL-17 activation as an autoantigen, can be used as a diagnostic marker and a therapeutic target of autoimmune skin diseases such as psoriasis and the like, and has broad application prospects. And a new direction is provided for mechanism research and treatment of autoimmune skin diseases such as psoriasis.

The application discloses a Lactiplantibacillus plantarum strain LP-14 and application thereof, the Lactiplantibacillus plantarum strain LP-14 is preserved in the China General Microbiological Culture Collection Center on June 3, 2024, and the preservation number is CGMCC No.30841.The application also provides application of the Lactiplantibacillus plantarum strain LP-14 in planting industry.Compared with the prior art, the Lactiplantibacillus plantarum strain LP-14 fermentation liquor can be applied to soil or leaf surface or seed surface, can rapidly reproduce by utilizing nutrients in the environment, can continuously inhibit other pathogenic bacteria and other microorganisms to occupy a microecological position advantage, avoid reproduction of harmful microorganisms, or directly stimulate the immune system of plants and seeds by contact and absorption of leaf surface and seeds, and improve the systemic resistance of plants.

The invention provides a phenoxy (hetero) aryl ether with anti-proliferative activity. The invention of the present application includes novel aromatic molecules useful in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders, such as disorders of the hematopoietic system, including the blood system, in human and veterinary medicine.

Provided herein are immunoconjugate molecules containing a TNF-α polypeptide and a masking moiety capable of inhibiting and activating the TNF-α activity under suitable conditions. Also provided herein are methods for producing the immunoconjugate molecules. Finally, provided herein are the therapeutic uses of the immunoconjugate molecules due to their modulating effects on the immune system for treating diseases such as cancer and other chronic infectious diseases.

The present disclosure provides anti-B7-H3 antibody variants with enhanced antigen binding affinity. The present disclosure also provides methods for using the anti-B7-H3 antibody for treating a cancer or modulating the immune system in a subject.

This invention discloses a method for preparing a core-shell microneedle patch loaded with dual nanoparticles, comprising: preparing silica nanoparticles loaded with oxyhemoglobin and dihydroporphyrin e6; preparing calcium carbonate nanoparticles loaded with aPD-1 antibody; dispersing the silica nanoparticles loaded with oxyhemoglobin and dihydroporphyrin e6 in a polyvinyl alcohol solution to prepare the shell structure of the microneedles; preparing a polymer hydrogel; dispersing the calcium carbonate nanoparticles loaded with aPD-1 antibody in the polymer hydrogel to prepare the core structure of the microneedles; and casting the polyvinyl alcohol solution onto the backing of the microneedles to finally obtain the core-shell microneedle patch loaded with dual nanoparticles. The core-shell microneedle patch loaded with dual nanoparticles prepared by this invention can deliver nanoparticles to the tumor site, where the nanoparticles respond to the tumor microenvironment and activate the body's own immune system, thereby achieving a therapeutic effect on tumors.

The present invention relates to a liquid-phase, supplementary feed composition containing coenzyme Q10 and, more specifically, to a liquid-phase, supplementary feed composition containing coenzyme Q10, conjugated linoleic acid, fructooligosaccharide, L-carnitine, and taurine at specific contents, whereby the composition can prevent aging and onset of cardiovascular diseases and cardiac disease, activate the immune system, and provide a diet effect in companion animals.

The present application relates to the technical field of information security, and more particularly to a dynamic white list management method and system based on immune-Kalman collaborative evolution, which comprises the following steps: receiving the observation data of the service access request collected and sent by the edge access gateway; predicting and updating the state vector of the current service baseline through the Kalman filter state estimator to obtain the prior state prediction value and the prediction residual; dynamically adjusting the "self-non-self" judgment threshold of the immune system, if it is judged as self, the characteristics of the service access request are fed back to the Kalman filter state estimator as observation samples and updated; if it is judged as non-self, an isolation instruction is generated and sent to the software defined network controller, and a denial of access instruction is sent to the edge access gateway; based on the prediction residual and the comprehensive health degree index, the running state of the system is judged, and the corresponding matching strategy is selected from the preset white list matching strategy set and sent to the edge access gateway for execution.

The present invention is directed to phage therapy for the treatment and control of bacterial infections, in particular urinary tract infections caused by Escherichia coli. More specifically, the present invention is directed to novel bacteriophage strains, cocktails thereof and variants thereof; and to methods using the same in the treatment, reduction or prevention of bacterial infections. The cocktail is used as a first line treatment against urinary tract infections, in particular in cancer patients, diabetic patients, or patients with a weakened immune system. Disclosed herein is a pharmaceutical composition comprising one or more purified strains of bacteriophage, each purified strain having a genome with at least 98% sequence identity to a nucleotide sequence selected from SEQ. ID No. 1, SEQ ID NO. 4, SEQ ID NO. 5 and SEQ ID NO. 6 and / or variants thereof. The pharmaceutical composition may also be used in combination with other therapies for urinary tract infections such as antibiotics. The pharmaceutical composition may also be used in a method of diagnosis of the causative agent of a bacterial infection. A bacteriophage comprising at least 95% sequence identity with SEQ. ID No. 1, SEQ ID NO. 5 or SEQ ID NO. 6 is also disclosed.

Provided are a jellyfish polypeptide, and a preparation method therefor and a use thereof. The jellyfish polypeptide provided by the present disclosure or a jellyfish polypeptide obtained by using the preparation method provided by the present disclosure exhibits a significant inhibitory effect on multiple tumors including colorectal cancer, lung cancer and prostate cancer, and also has a regulating function on mammalian immune systems.

The present invention relates to a method for preparing a tropical fish feed by using brine shrimp, and a tropical fish feed prepared thereby, and, more specifically, to: a method for preparing a tropical fish feed by using brine shrimp, and a tropical fish feed prepared thereby, the method feeding spirulina and Haematococcus to hatched brine shrimp to prepare a tropical fish feed, and thus can promote the growth of tropical fish, boost the immune system and improve the consumption, digestion, absorption and palatability for tropical fish.

The present disclosure relates to a novel recombinant influenza virus, in which an interferon-beta gene, which is a foreign gene associated with an antiviral action, is introduced to an NS1 gene which is an influenza virus gene that is expressed first in the host to suppress the host immune system when infected with the influenza virus, and, in contrast to existing research, the interferon-beta is separated from the NS1 protein to carry out an intrinsic function of interferon-beta of inducing an antiviral action.

There is a great amount of people suffering from hair loss or baldness due to stress, hormonal changes, male baldness, side effects of drugs or vaccines, aging or immune system problems; and there are also some people who do not have the aforementioned problems but still have a need for increasement of hair volume. To solve the aforementioned problems, a use of polymer dot in manufacture of a composition for the enhancement of hair growth or the prevention of hair loss is provided, in order to enhance hair growth of a patient with hair loss or baldness and to prevent hair loss of a non-patient. The polymer dot includes a carbon dot.

The invention discloses a bronchial lung dysplasia severity prediction method and related equipment, and belongs to the technical field of machine learning, and the method comprises the steps: obtaining the clinical data of a target object; preprocessing the clinical data of the target object, constructing a training set and a verification set according to a preset proportion, and screening to obtain a target variable; based on the target variable, constructing a plurality of bronchial lung dysplasia severity prediction models by using the training set, and performing model performance evaluation on the plurality of constructed bronchial lung dysplasia severity prediction models in the verification set; and obtaining a bronchial lung dysplasia severity prediction model with the optimal performance so as to complete bronchial lung dysplasia severity prediction. The clinical data of the target object is combined with the machine learning algorithm, so that the dynamic change of the immune system of the premature infant can be reflected more comprehensively, the prediction accuracy of the severity of early bronchial pulmonary dysplasia is improved, and scientific data support is provided for clinical treatment selection.

Synthetic hemocompatible vascular grafts manufactured from polyvinyl alcohol-based biomaterials containing crystalline segments of polyvinyl alcohol, which are long-term fully functioning vascular grafts that provide no activity towards immune systems in recognizing surfaces as foreign bodies that would normally lead to fibrosis, platelet activation and subsequent thrombi formation, and thus occlusion of the grafts.

The invention provides methods and compositions for modulating the immune system of an individual. The methods provided herein entail administering a composition comprising a killed or inactivated Mycobacterium or antigenic fragments derived therefrom. Also provided herein are methods for assessing alteration of immune system functioning following administration of a composition comprising aa killed or inactivated Mycobacterium or antigenic fragments derived therefrom.

The invention discloses an optimized formula of plant organic nano-selenium for activating an immune system, inhibiting cancer cell proliferation, preventing cancers, preventing tumors, resisting oxidation and resisting aging, and belongs to the technical field of functional food formulas. According to the formula, selenium-enriched yeast and dl-alpha-tocopheryl acetate are used as main materials, L-ascorbic acid can be selectively added, auxiliary materials such as microcrystalline cellulose and starch sodium octenylsuccinate are matched to prepare a capsule preparation, and the content of functional components in a single preparation is precisely controlled as follows: 90-100 micrograms of selenium and 40-50 mg of vitamin E, or 90-100 micrograms of selenium, 40-50 mg of vitamin E and 40 mg of vitamin C. According to the invention, synergistic interaction is realized through scientific proportioning of functional components, a fat-soluble and water-soluble dual anti-oxidation system is constructed, an organism immune system can be effectively activated, cancer cell proliferation can be inhibited, and meanwhile, the composition has multiple effects of preventing cancers, preventing tumors, resisting oxidation and resisting aging; the preparation method is simple and convenient in process, easy in parameter control and suitable for industrial large-scale production, the prepared preparation is high in active ingredient stability, excellent in bioavailability, high in safety and capable of being widely applied to preparation of related functional foods, and all raw materials are food-grade. The technical problems that an existing selenium compound formula is unreasonable in proportion, poor in efficacy synergy and poor in preparation performance are solved.

Compounds (I), compositions, and methods for use in degrading Aurora kinase are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising Aurora kinase degraders, as well as methods for treating cancer using Aurora kinase degraders.