12results about How to "Extend cycle time" patented technology

The invention discloses an oligomeric amino acid dendritic macromolecular material as well as a preparation method and application thereof, and relates to the technical field of nano materials. The general formula of the oligomeric amino acid dendritic macromolecular material is TPE-(PEG) n-(Lys) x-(Arg) y, wherein TPE is a hydrophobic core, has an aggregation-induced emission characteristic, and can enhance the self-assembly capability and the tracing function of the nano-carrier; pEG is a connecting arm, so that the water solubility and biocompatibility of the material can be improved; lys is a branch skeleton and is a main construction unit of a dendritic macromolecule; arg is a functional terminal, guanidyl of Arg has strong positive charges, electrostatic binding with negatively charged nucleic acid can be promoted, and meanwhile cellular uptake can be enhanced possibly through the membrane penetration effect. The oligomeric amino acid dendritic macromolecular material gives consideration to stability, modifiability and targeting, provides a new scheme for small nucleic acid delivery, and is expected to have far-reaching influence in the fields of precise tumor treatment, gene therapy and multi-modal diagnosis and treatment.

This invention discloses nanoparticles that enhance the near-infrared II fluorescence of indocyanine green, their preparation method, and applications. The nanoparticles are prepared by mixing PLGA-PEG-PLGA and ICG-NHS. The specific method is as follows: S1, dissolve PLGA-PEG-PLGA in a solvent to form a first solution; S2, dissolve ICG-NHS in a solvent to form a second solution; S3, thoroughly mix the first and second solutions, react them, and remove unreacted substances by ultrafiltration to obtain the nanoparticles. The order of steps S1 and S2 is not limited. This invention enhances the emission of ICG through PLGA-PEG-PLGA, extending the application of ICG in the near-infrared II region to the NIR-IIa region (1300nm-1400nm), and effectively prolongs the circulation time of ICG in the blood, thus removing limitations in its application in fields such as tumor and vascular disease diagnosis.

The application discloses a pPAM long-circulating liposome, a preparation method and application thereof, and the long-circulating liposome takes a blank liposome as a carrier, internally carries a plasmid pPAM, and is decorated on the surface with a transferrin-penetratin complex Tf-Pen and an oxytocin receptor antibody OTR Ab； The plasmid pPAM carries a cDNA sequence of a peptide acylglycine alpha amidation monooxygenase PAM; and the blank liposome is composed of DSPC, PEG 2000 , cholesterol and lecithin. The application provides a new direction for development of endogenous polypeptide synthesis enzyme delivery technology and mental drugs, and improves the possibility of preparing new anti-anxiety and depression drugs, relieving mental stress and improving patient compliance.

The utility model discloses a methanol vaporizer with inner fins. The methanol vaporizer comprises a vaporizer body, a liquid inlet pipe is arranged close to the upper end of one side of the device body, and a liquid outlet pipe is arranged close to the lower end; the heat exchanger further comprises an inner sleeve, fins and turbulent flow blocks. The fins are fixed to the outer side of the inner sleeve at intervals, and the outer side faces of the fins are fixedly connected with the inner side face of the device body. Notches are formed in the fins, and the positions of the notches in the adjacent fins are different; the end of the liquid inlet pipe extends to the position above the fin at the uppermost end, and the end of the liquid outlet pipe extends to the position below the fin at the lowermost end. The heat exchanger is good in heat exchange effect, and the influence on a heating assembly in the heat exchanger body is small.

The invention provides a quaternary high-entropy alloy nano enzyme as well as a preparation method and application thereof, and belongs to the technical field of nano biological materials and biological medicines. The quaternary high-entropy alloy nano-enzyme comprises a single-phase alloy and polyvinylpyrrolidone, the single-phase alloy is composed of four metal elements of M, rhodium, iridium and ruthenium, the surface of the single-phase alloy is modified with the polyvinylpyrrolidone, the element M is selected from palladium or platinum, and the particle size of the quaternary high-entropy alloy nano-enzyme is smaller than 10 nm. The quaternary high-entropy alloy nano-enzyme disclosed by the invention can penetrate through a blood brain barrier, is enriched at a cerebral hemorrhage focus, and comprehensively blocks reactive oxygen species (ROS) cascade reaction after cerebral hemorrhage.

The invention provides a nano preparation for preparing a medicine for inhibiting prostatic cancer and a preparation method of the nano preparation, and relates to the technical field of nano medicinal preparations. The nano preparation comprises the following components in parts by mass: traditional Chinese medicine components and a nano carrier, the traditional Chinese medicine component comprises 15-45 parts of a Chinese yam extract, 5-15 parts of a madder extract, 8-20 parts of cuttlebone superfine powder, 10-25 parts of dragon bone superfine powder and 10-25 parts of oyster superfine powder; the nano-carrier comprises 5-20 parts of phospholipid, 2-10 parts of cholesterol, 1-5 parts of fatty acid, 3-15 parts of polyethylene glycol and 1-5 parts of a surfactant. The average particle size of the nano preparation is 80-150 nm, the polydispersity index PDI is smaller than or equal to 0.30, and the encapsulation efficiency is larger than or equal to 75%. According to the invention, active ingredients of traditional Chinese medicines are combined with a nanotechnology, so that the bioavailability and the tumor targeting property are remarkably improved, the pH-responsive release characteristic is achieved, a remarkable inhibition effect on various prostate cancer cell lines is shown, tumor growth can be effectively inhibited, metastasis can be reduced, and a good application prospect is achieved.

This invention belongs to the field of medicinal chemistry, specifically relating to a mitochondrial-dequinoline chloride-hyaluronic acid compound, its preparation method, and its application. The rotenol-dequinoline chloride-hyaluronic acid compound has the following structural formula, where n is 2. Based on the anticancer activity of rotenone, this invention utilizes reduction, esterification, and two amide reactions to successfully link rotenol, dequinoline chloride, and hyaluronic acid via amide bonds. Subsequently, these components are successfully self-assembled into spherical nanoparticles using ultrasound, constructing a rotenol-dequinoline chloride-hyaluronic acid nanosystem for tumor therapy. After targeted delivery of these nanoparticles to tumor cells, both rotenol and dequinoline chloride synergistically act on the mitochondria, forming a dual-drug delivery system that generates a large amount of ROS, thereby inducing apoptosis and effectively inhibiting tumor growth and migration.

This invention provides the application of the LHPP gene in liver cancer immunotherapy and liver cancer immunotherapy drugs. Reagents that promote LHPP gene expression can be used to prepare liver cancer immunotherapy drugs. This invention also provides an mRNA nanomedicine, which is prepared by the following method: [The invention then describes a process involving Meo-PEG-Dlink]. m A PLGA solution, an aqueous solution of LHPP gene mRNA, and a cationic liposome solution were mixed and added dropwise to water under stirring to obtain a nanosolution. The nanosolution was then transferred to an ultrafiltration membrane and centrifuged. This invention is the first to discover that LHPP can participate in the immunotherapy of liver cancer and is associated with the survival prognosis of liver cancer. LHPP enhances STAT1 nuclear translocation by affecting the expression of autophagy-regulated IFNβ, thereby promoting the expression of T cell-related chemokines secreted by liver cancer cells, and ultimately promoting CD8+ expression. + T cell infiltration. Therefore, the LHPP gene can serve as a novel target for immunotherapy of liver cancer. The mRNA nanomedicine described has advantages such as long circulation time in the blood, high accumulation in tumors, rapid mRNA release, and low cost.

The present invention relates to processes for the preparation of Tyk2 inhibitors. In particular, the present invention relates to improved processes for the synthesis of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide, Compound I, which is currently in clinical trials for the treatment of autoimmune and autoinflammatory diseases such as psoriasis.

This invention discloses a bioactive nanomicelle based on idebenone. By designing idebenone molecules with hydrophobic ends and functionalized hydrophilic polyethylene glycol, it exhibits excellent responsiveness, antioxidant properties, and cellular safety, making it suitable as a carrier for delivering drugs, genes, or other bioactive molecules for therapeutic and diagnostic applications. This invention also discloses a method for preparing this idebenone-based bioactive nanomicelle. The method for synthesizing the amphiphilic polymer of IDBP is simple, with mild reaction conditions, easy synthesis, convenient post-processing, high yield, and easy industrial production. The prepared amphiphilic polymer exhibits spontaneous assembly behavior in aqueous solution, forming a stable nanomicelle structure. This demonstrates the great potential of idebenone-based bioactive nanomicelles in drug delivery, potentially improving drug stability, bioavailability, and targeting.

A method for forming a folded edge of a component includes providing a first blank and a second blank. The method further includes applying an adhesive to the top surface of the first blank with an adhesive dispenser. The method further includes positioning a second blank over the first blank, where a lower surface of the second blank is positioned over a top surface of the first blank such that an adhesive is applied between the lower surface of the second blank and the top surface of the first blank. The method further includes folding the first edge of the first blank over the second blank such that a portion of the top surface of the first blank overlies the upper surface of the second blank. A dispensing end portion of the adhesive dispenser defines an opening that is wider in the width direction than in the height direction.

The invention discloses a trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition and application, and relates to the technical field of delivery and drug combination, and the trabectedin-loaded nano-micelle and oxaliplatin-loaded drug combination composition comprises trabectedin-loaded nano-micelle and oxaliplatin. The invention also discloses an application of the combined pharmaceutical composition in preparation of antitumor drugs. According to the invention, a pH-sensitive amphiphilic biodegradable material (such as PCL-PEOz) and a chemical drug are self-assembled to form stable micelles, so that the bioavailability of the drug is improved, the critical concentration of the micelles is reduced, and long-acting circulation in vivo is realized; the system can be combined with oxaliplatin for use, so that the sensitivity of tumor cells to oxaliplatin is promoted, the synergistic effect of chemotherapy and immunotherapy is exerted, the treatment effect of malignant tumors is improved, and the tumor microenvironment is improved.