1005results about How to "Extend cycle time" patented technology

Design driven inspection / metrology methods and apparatus are provided. A recipe is a set of instructions including wafer processing parameters, inspection parameters, or control parameters for telling an inspection / metrology system how to inspect / measure a wafer. Design data is imported into a recipe extraction system that recognizes instances of target structures and configures recipe parameters accordingly, thereby reducing manual instrument setup time, improving inspection / measurement accuracy, and improving fabrication efficiency.

A process for direct hydroliquefaction of biomass selected from algae, lignocellulosic biomass and / or of one or more constituents of lignocellulosic biomass selected from the group comprising cellulose, hemicellulose and / or lignin for producing fuel bases comprising two successive hydroconversion stages under high hydrogen pressure in ebullating bed reactors. Hydroconversion takes place in the presence of a supported catalyst of the type for hydroconversion of petroleum residue and a suspension composed of the biomass and a solvent, preferably a hydrogen donor solvent and preferably recycled from the process. The biomass can undergo a pretreatment of drying and / or roasting and / or grinding and / or demineralization prior to hydroliquefaction.

A vehicle part such as a body molding includes a trim piece connected to a bearer piece by a flexible and foldable hinge, which is preferably integrally molded with the trim and bearer pieces in a single injection mold. The trim piece and bearer piece are folded about the molded hinge to rotate towards each other and are snap-fitted together to form an integral body side molding that can be adhesively and / or clippedly affixed to a support surface, such as a vehicle body side panel. Methods for manufacturing and installing such vehicle parts are also disclosed.

The invention relates to the field of specific molecular identification and diagnosis reagent and in particular discloses a near infrared fluorescent dye with structural formulas I and II; and the invention also discloses a near infrared molecular probe which is obtained through covalent bonding between the near infrared fluorescent dye with the structural formulas I and II and a ligand of specific molecules. The near infrared molecular probe can be used for early diagnosis of turmour diseases.

Robotic external pipeline crawler system employs the use of logic control to provide a system capable of constantly and accurately maintaining a position at the vertex of the pipe. This apex positioning can be maintained as it traverses the length of the pipe being inspected. This system is adaptable to both straight and curved pipe, multiple pipe diameters, and will substantially reduce set up time and vertical pipeline support crossing time. The crawler system also employs an advanced bracketry system which allows quick disconnecting and auxiliary powered movement allowing for decreased cycle time across pipe supports. The unique tire interface allows for additional surface area contact making extreme environmental conditions possible.

An apparatus and method of optimizing collision free path planning comprising: initializing a plurality of feasible configuration points, sample points located in a free space, and sample points not located in the free space; determining a goodness rating of the various pluralities of points; generating new candidate points; determining if each new candidate point is a feasible configuration point and adding each to the plurality of feasible configuration points if it is; if not, determining if each new candidate point is located in the free space and adding it to the plurality of sample points located in the free space if it is; if not, adding to the plurality of sample points not located in the free space; determining an updated goodness rating of the various pluralities of points; determining if a termination criteria has been met and reporting a best solution or no solution if it has been met.

A process for cracking an olefin-rich hydrocarbon feedstock which is selective towards propylene in the effluent, the process comprising contacting a hydrocarbon feedstock containing one or more olefinic components of C4 or greater with a crystalline silicate catalyst to produce an effluent having a second composition of one or more olefinic components of C3 or greater, the feedstock and the effluent having substantially the same olefin content by weight therein characterized in that ethylene is added to the feedstock before the feedstock contacts the catalyst.

The invention relates to a temperature-controlled injector for a chemical analysis unit, in particular a gas chromatograph, comprising an injector tube, which can be received by a receiving tube, having a cooling system, which surrounds the receiving tube, through which coolant can flow, which has coolant connections and which is designed as a metallic tube coil, and a resistance heating system for the injector tube, in which injector the receiving tube consists of a material of good thermal conductivity, is electrically insulating towards the outside, and the tube coil rests on the receiving tube, has an electrical resistance which is sufficient to rapidly heat the injector tube and can be acted on by current via electrical connection pieces.

The invention provides a ternary positive electrode material lithium ion battery electrolyte, and relates to the technical field of a lithium ion battery. The ternary positive electrode material lithium ion battery electrolyte comprises a carbonate ester organic solvent, a lithium salt and an additive, wherein the lithium salt is lithium hexafluorophate, the lithium hexafluorophate accounts for 12-18% of the total mass of the lithium salt and the carbonate ester organic solvent, and the additive accounts for 5-15% of the total mass of the lithium salt and the carbonate ester organic solvent. The carbonate ester organic solvent is used, so that the solvent is high in solubility of the lithium salt and low in viscosity; and meanwhile, fluoroethylene carbonate is used as a low-temperature additive, the electrolyte is compatible with the electrochemical performance such as capacity and internal resistance, the ternary positive electrode material battery also has excellent cycle property, and the cycle time of the battery under a low-temperature condition is prolonged.

The invention discloses a preparation method of a polyene-containing taxol nanoparticle mixed micelle preparation and a freeze-drying agent, which prepares docetaxel PLA-PEG nanoparticles or micelle or nanoparticle mixed micelle through a modified solvent evaporation method, takes PLA-PEG copolymer as a carrier, and wraps docetaxel in a PLA hydrophobic core. When in use, the docetaxel PLA-PEG containing long cycle freeze-dried preparation only needs to be added with water and is dissolved, and uniform nanoparticle suspension, micellar solution or mixed micellar nanoparticle suspension can be prepared. The preparation method does not need tween-80 and ethanol solubilization, only takes the biodegradable PLA-PEG as the carrier, and does not contain any surfactant; and compared with the docetaxel injection on sale, the preparation can reduce the toxicity and the adverse reactions of the medicine, and improve the clinical application safety of the medicine.

The invention is directed to a friction stir welding tool cleaning method and apparatus for fixed and retractable pin tools. The method and apparatus use a heating component, a temperature indicator component, a controller component, and a rotatable tool cleaner component for cleaning fixed pin tools. An additional bore cleaner component is used for cleaning retractable pin tools. Heat is applied to a friction stir welding tool having a surface with weld process residue material until the process residue material is sufficiently plasticized, and then the tool cleaner component is applied to the heated tool to remove the plasticized residue on the pin and shoulder surfaces of the tool, and for retractable pin tools, the bore cleaner component is applied to the heated tool to remove the plasticized residue in the tool bore.

A thermostat, of the type that employs latching relays to connect thermostat power to the various wires of the thermostat run, has a re-pulse feature that supplies latching pulses at a given interval, e.g., three hours, to ensure that the relays are in their proper state agreeing with the thermostat mode and the room temperature relative to the setpoint(s). In the case that the room air temperature is changing in a manner contrary to the current heating or cooling mode, which may indicate the latching relay has been knocked or bumped and needs to have its proper state re-established, the thermostat microprocessor issues pulses to the latching relay(s) more frequently, e.g., each 30 minutes, and the re-pulses may have a longer pulse width, e.g., increased from 20 ms to 25 ms.

The invention belongs to the technical field of biomedical nanomaterials, and discloses a pH-responsive schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as a preparationmethod and application thereof. The nanoparticle provided by the invention comprises a mesoporous silica nanoparticle, a drug loaded inside the mesoporous silica nanoparticle, and a polymer modifiedon a surface of the mesoporous silica nanoparticle; and the polymer modified on a surface of the mesoporous silica nanoparticle is specifically P (PEGMA-co-MAEBA) modified on the surface of the mesoporous silica nanoparticle by an imine bond. The nanoparticle material provided by the invention has good biocompatibility, and realizes controlled release of the drug by utilizing an acid-sensitive imine bond; the drug is hardly released around normal cells, but the imine bond is broken in a slightly acidic environment of tumor cells, and the polymer falls off to rapidly release the drug, thereby realizing targeted therapy for the tumors; and the nanoparticle material is applicable to the field of controlled release of drugs.

The invention relates to a folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as a preparation method and application thereof. The delivery carrier is prepared by taking anamphiphilic triblock copolymer PCL-ss-PEG-ss-PCL as a material, and a chemotherapeutic drug adriamycin amycin and a photosensitizer indocyanine green are entrapped in a hydrophobic core of the micelle. Besides, phospholipid DSPE-PEG-NH2 with an active group is introduced into the preparation process, the DSPE end of the phospholipid has strong hydrophobic property and is inserted into the hydrophobic PCL core of the polymer micelle, the flexible hydrophilic PEG long chain exists on the outer surface of the micelle, FA with a targeting effect is connected to a PEG active distal end of the surface of the polymer micelle, and functions of active tumor targeting and reduction response drug release are integrated. The folate-targeted reduction sensitive drug-carrying polymer nano-micelle disclosed by the invention has the advantages of being small in particle size, high in dispersion property, high in drug loading capacity and encapsulation efficiency and excellent in photothermal conversion effect, can realize reduced trigger drug release, fluorescence imaging of tumor sites, tumor targeting drug delivery and chemotherapy-photothermal combination therapy and improve the tumor inhibition effect, and has wide application prospects in the targeted combination therapy aspect of tumors.

The present invention relates to a dental firing furnace having a firing space and at least one carrier for dental material, in particular a muffle, which can be loaded into the firing space, and, in particular, a pressing device for pressing a ceramic blank inserted in the muffle, at least one physical variable of the firing space and / or of the carrier and / or of the muffle and / or of the ceramic blank being detected. A processing program of the dental furnace (10) that can be set is based on the detected physical variable.

A system and related techniques generate an interrogation request from an initiator device, such as a client desktop machine or other machine, to a mobile or other media player, such as a digital camera, MP3 player, video camera or other device or hardware to enumerate the media content contained in that device, along with associated properties. The collection of binary objects which encode the content, such as digital photographs, encoded audio files, digitized video or other media, may include or have associated with them a set of corresponding object properties which help to define each object, such as by defining a pixel color depth, audio codec or other property or attribute. According to embodiments of the invention, the initiator may communicate with the responding device using a media-aware protocol supporting an aggregate object property request, such that the initiator may identify one or all of the set of properties paired with all of the objects to be returned along with an enumeration of those objects. The initiator may then present, for example, a list of song titles along with the corresponding artist, track length, codec, display skins or other attributes or properties to a user, for example to select, delete, copy or otherwise manipulate the underlying objects, which may in one regard be separately retrieved from their identifier and properties. Because properties may be retrieved in conjunction with, at the same time and using a unified retrieval scheme, the need to query each object identifier one by one for associated properties is removed. The throughput and responsiveness of object property retrieval is therefore significantly enhanced.

The invention relates to a pH / reduction dual-sensitive multifunctional nano-micelle for tumor chemotherapy and photothermal combined therapy and application of the pH / reduction dual-sensitive multifunctional nano-micelle. The pH / reduction dual-sensitive multifunctional nano-micelle is characterized in that a PCL-acetal-PEG polymer with pH sensitive characteristic, a PCL-ss-PEG-ss-PCL polymer withreduction sensitive characteristic and a phospholipid DSPE-PEG-NH2 with an active group are used as raw materials and are blended to prepare a pH / reduction intelligent responsive polymer nano-micelleas a carrier; a chemotherapeutic drug and a photosensitizer coat a hydrophobic core of the micelle; a casing is made of hydrophilic PEG and has the characteristic of long circulation and space stability; a folic acid targeting group is modified on the surface of the micelle by a covalent bond; the drug loading capacity is 4 to 10 percent, and the mass ratio of the chemotherapeutic drug to the photosensitizer is 0.5 to 2; the particle size is smaller than 200 nm. The pH / reduction dual-sensitive multifunctional nano-micelle disclosed by the invention has the advantages of good dispersity, smallparticle size, better photothermal conversion effect and high drug loading capacity and encapsulation efficiency; the effect of improving tumor suppression by tumor targeted administration, fluorescence imaging of a tumor site, pH / reduction triggered drug release and chemotherapy and photothermal combined therapy can be realized; the pH / reduction dual-sensitive multifunctional nano-micelle has a broad clinical application prospect in combined targeting therapy of tumors.

The invention provides a novel polypeptide modified tumor targeted liposome of a targeted integrin receptor. The novel polypeptide is mainly formed by covalent linkage of ring-shaped RGD and cell penetrating peptides, and not only has the selective targeting capability of an integrin receptor, but also can achieve mediated endocytosis; the liposome mainly comprises phospholipid, cholesterol, lipid-polyethyleneglycol and lipid-polyethyleneglycol-novel polypeptide ligand chimeric substance, and is a very potential tumor targeted treatment carrier.

The invention relates to a multi-function nano prodrug system based on a dendrimer, which belongs to the technical field of biomedicines and nano medical science. The nano system comprises four function parts: an outermost layer RGD (arginyl-glycocoll-aspartate) cyclic peptide as an active targeting head group (1), a polyethylene glycol (PEG) hydrophilic chain segment (2) connected with the targeting head group and the dendrimer, an anti-tumour drug (3) connected with the dendrimer by an acid sensitive chemical bond and a dendrimer kernel (4). The general formula of the nano system is RGD-PEG-Dendrimer-DOX (doxorubicine), wherein the macromolecule attribute of a dendrimer vector makes a vector system passively target to tumor tissues through an EPR (Enhanced Permeability and retention) effect; the RGD cyclic peptide makes the vector system actively target to the tumor tissues through the interaction of a ligand and a receptor and promotes the endocytosis of the tumor tissues; the acid sensitive chemical bond ensures that a drug-carrying system is stable in systemic circulation and releases active drugs after arriving tumor positions and entering an acid organelle to perform the function of cytotoxicity.

The invention discloses long-circulating solid lipid docetaxel nanoparticles and a preparation method thereof. The long-circulating solid lipid docetaxel nanoparticles comprise the following materialsin therapeutic effective dose: docetaxel, lipid materials, long-circulating auxiliary materials and an emulsifier. The long-circulating solid lipid docetaxel nanoparticles have small particle size, high encapsulation rate and good stability, and not only improve the solubility and the stability of the docetaxel, reduce the toxicity of the docetaxel, but also prolong the circulating time of a medicament in blood, and improve the therapeutic index of the medicament, so that the preparation has the characteristics of low toxicity, low allergy, high efficiency and targeting in clinical application.

The invention belongs to the field of medicine preparation and particularly relates to a docetaxel solid lipid nanoparticle and a preparation method thereof. The docetaxel solid lipid nanoparticle consists of an effective curative dose of docetaxel, solid lipid materials, liquid lipid materials, an emulsifying agent, additives, long-circulating auxiliary materials and water for injection. The docetaxel solid lipid nanoparticle provided by the invention has the characteristics of stable docetaxel structure, phagocytosis prevention of an in-vivo reticuloendothelial system and active tumor targeting, and can be stably stored.

The present invention features processes of making tablets having reduced internal fractures. In one aspect, the processes comprise the steps of (1) compressing a pre-tabletting material in a die to form a tablet, where an internal surface of the die is lubricated with at least one lubricant and the pre-tabletting material comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer; and (2) ejecting said tablet from said die. In another aspect, the processes employ a granular or powdery pre-tabletting material which comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer, wherein 90% of the particles in the pre-tabletting material are smaller than 400 μm.

An injection-molded plastic part cooling tube has an extruded cylindrically shaped tube with an inside surface and an outside surface. An extruded cooling channel is disposed inside the cylindrically shaped tube, between the inside surface and the outside surface. A method for forming an injection-molded-plastic-part cooling tube includes the step of extruding a hollow aluminum tube having an inside surface, an outside surface, and at least one cooling channel in the hollow aluminum tube between the inside surface and the outside surface. Alternative cooling tubes include a tubular porous insert for vacuum forming molded articles.

The present invention is intended to realize a hold posture inspection of a plurality of components sucked by a plurality of nozzle rows provided on a head with a single scanning operation, thereby reducing the time for the hold posture inspection and improving the accuracy thereof. In order to achieve such objections, the present invention includes: a head on which at least two nozzle rows are disposed, each of which includes at least one nozzle; a circuit board holding unit for holding a circuit board on which components conveyed by the head are mounted; and an inspection unit, provided on a moving path of the head from a supplying unit to the circuit board holding unit, for inspecting hold postures of the components held by the nozzles of the head and including sensors for posture inspection independent for the respective nozzle rows.