134results about How to "Extend cycle time" patented technology

The invention relates to the technical field of atherosclerosis related drugs, in particular to a macrophage membrane functionalized manganese dioxide nano-drug as well as a preparation method and application thereof in treatment of atherosclerosis. The invention relates to a macrophage membrane functionalized manganese dioxide nano-drug, which comprises an HMnO2 carrier, colchicine is loaded on the HMnO2 carrier, and a macrophage membrane is coated outside the HMnO2 carrier. The preparation can be applied to practical operation of preparing medicines for treating atherosclerosis. According to the technical scheme, the technical problem of limited treatment effect caused by single action mechanism of medicines for treating atherosclerosis in the prior art can be solved. The nano-drug in the scheme can remove ROS to play an anti-inflammatory effect, reprogram macrophages and promote cholesterol excretion, and is used for synergistically treating atherosclerosis. The macrophage membrane can target an inflammation part and escape from an immune system. And the side effect of the nano-drug is relatively small, so that the nano-drug has ideal popularization and application prospects.

The invention relates to the technical field of medicine, and discloses an artificial exosome and application thereof in drug delivery, the artificial exosome is prepared into an oil phase based on PLGA and DOTAP, and a water phase based on OCT4 protein and siTrim28; mixing the two phases to obtain a primary emulsion, and adding a PVA aqueous solution to obtain a double emulsion; stirring the double emulsion and volatilizing the solvent to form an emulsified solution, and centrifuging to obtain PLGA nanoparticles; the lipid mixture is prepared from lipid, DPPE-PEG2000, alpha-tocopherol and alpha-lactalbumin, and a lipid film is formed after a solvent is evaporated; the preparation method comprises the following steps: mixing PLGA nanoparticles, a lipid film and membrane protein, uniformly mixing and heating to obtain a film-coated solution, and finally extruding through a cellulose acetate film to obtain the artificial exosome. The artificial exosome disclosed by the invention combines the stability of the PLGA nanoparticles and the biocompatibility of the lipid membrane, and provides new possibility for a drug delivery system.

The invention discloses a kaempferol mesenchymal stem cell membrane biomimetic material which can be targeted to injured tissues more accurately. The bionic nano material is simple in preparation method, high in universality and convenient for large-scale production, and the mesenchymal stem cell membrane is utilized to improve the biocompatibility and targeting property of the carrier and prolong the in-vivo circulation time of the medicine; the bionic nano material prepared by the invention realizes targeted delivery of kaempferol to the liver, and provides a novel treatment mode for acute hepatic failure ALF.

The invention discloses a near-infrared light nano probe as well as a preparation method and application thereof. The preparation method of the near-infrared nano probe comprises the following steps: dissolving polylactic acid-co-acetic acid in an acetonitrile solution, and adding lecithin and 1, 2-dipalmitoyl-sn-glycerol-3-phosphatidyl glycol to obtain a solution A; dissolving indocyanine green in an ethanol solution to obtain a solution B; and mixing the solution A and the solution B, and carrying out ultrasonic treatment to obtain the near-infrared nano probe. The near-infrared light nanoprobe can be used for imaging diagnosis of acute kidney injury, and effectively solves the problems of long diagnosis time, poor stability, high in-vivo clearance rate, low cell absorption rate and the like. Compared with existing ICG nano-particles, the ICG nano-particles are high in biological tissue penetrability, high in resolution ratio, low in phototoxicity and good in fluorescence imaging effect in an acute kidney injury model and have wide application prospects in AKI clinical diagnosis.

The invention belongs to the technical field of medicines, and discloses a cationic lipid C6-A1, a nano-liposome particle composed of the same and a preparation method of the nano-liposome particle, and the stability is improved: the stability of the nano-liposome can be remarkably improved through the structural design and PEG modification of the C6-A1 lipid, and in-vivo degradation is reduced. And the optimized preparation method and introduction of cationic lipid can improve the encapsulation efficiency of drugs and genes. And the PEG modified lipid can reduce the recognition of an immune system, prolong the circulation time of the liposome in blood and improve the targeted transmission capability. The cation characteristic of the C6-A1 is beneficial to the combination and endocytosis of the gene and a cell membrane, and the gene transfer efficiency is improved.

The invention provides a PVDF-PMMA (Polyvinylidene Fluoride-Polymethyl Methacrylate)-based polymer electrolyte membrane as well as a preparation method and application thereof, and belongs to the field of lithium batteries. The invention provides a PVDF-PMMA (Polyvinylidene Fluoride-Polymethyl Methacrylate)-based polymer electrolyte membrane. The PVDF-PMMA-based polymer electrolyte membrane is prepared from the following components: PVDF, PMMA, a lithium salt, an active filler and a phosphine compound, the mass ratio of the PVDF to the lithium salt is (2-15): 1; the mass ratio of the PVDF to the PMMA is (1-10): 1; the ratio of the total mass of the PVDF and the lithium salt to the mass of the active filler is (2-30): 1; the ratio of the total mass of the PVDF and the lithium salt to the mass of the phosphine compound is (5-30): 1. The polarity of the phosphine compound is high, and the phosphine compound can promote dissociation of lithium salt, so that rapid and efficient transmission of lithium ions in the PVDF-PMMA-based polymer electrolyte membrane at room temperature is promoted, and the conductivity of the PVDF-PMMA-based polymer electrolyte membrane is further improved.

The invention discloses a trimethylolethane modified aqueous zinc ion battery electrolyte and an aqueous zinc ion battery. Wherein the aqueous zinc ion battery electrolyte comprises soluble zinc salt, trimethylolethane and water, after a trimethylolethane additive rich in polar groups (-OH) is introduced into the electrolyte, a zinc negative electrode can be covered by trimethylolethane molecules, and the adsorption of H2O is hindered, so that the side reaction is inhibited; and meanwhile, the adsorbed trimethylolethane adjusts the diffusion and nucleation behaviors of Zn < 2 + > on the surface of the negative electrode, and promotes the preferential deposition of a Zn (002) texture, so that dendrite-free Zn deposition is realized, and the problems of dendrite, hydrogen evolution, corrosion and the like of the current aqueous zinc ion battery negative electrode are solved. Besides, the trimethylolethane adsorbed on the surface of the electrode regulates the double electrode layer at the interface of the zinc negative electrode, so that the number of water molecules in the double electrode layer is reduced, the cycle time of the zinc negative electrode can be effectively prolonged, and the device life of the water-based zinc ion battery is prolonged.

The invention belongs to the technical field of medicines, and relates to a cholesterolized rapamycin liposome as well as preparation and application thereof. The invention relates to a cholesterylated rapamycin liposome, which is prepared from cholesterylated rapamycin, phospholipid and a phospholipid PEG (Polyethylene Glycol) derivative. The liposome is mainly composed of a rapamycin cholesterol conjugate, the coupling effect of cholesterol and rapamycin indirectly enables a drug and phospholipid to be tightly combined, compared with free rapamycin, the entrapment efficiency is greatly improved, the leakage rate is reduced (the entrapment efficiency is improved by 8.05%, and the leakage rate is reduced by 100%), the entrapment efficiency of the preparation is as high as 95% or above, and the preparation has good application prospects. The particle size is about 120nm, the PDI is less than 0.2, the drug can be stably delivered in vivo, the circulation time of the drug in vivo is prolonged, the toxic and side effects are reduced, the safety is improved, the stability is good, and the storage, transportation and use are facilitated.

The invention belongs to the technical field of medicines, and particularly relates to enhanced penetration type double-response nanoparticles for co-delivery of chemotherapeutic drugs and gene drugs as well as a preparation method and application thereof. According to the invention, albumin is used as a carrier of gemcitabine, an ROS responsive charge reversible cationic polymer is used as a delivery carrier of siRNA, and gemcitabine drug-loaded albumin and siRNA drug-loaded B-PDEA nanoparticles are coupled through MMP-2 responsive polypeptide to form the drug-loaded nanoparticles. After reaching a tumor area through the active targeting effect of albumin, the nanoparticles can be cut by MMP-2 in a microenvironment and release drug-loaded albumin, so that the size of a delivery system is reduced, and further tumor deep penetration and enhanced gemcitabine uptake are realized; meanwhile, after intracellular high-level ROS is recognized, the loaded siRNA can be selectively released and inhibit CD39 expression, tumor metabolism is adjusted, an immune microenvironment is remodeled and an anti-tumor immune response is activated to further realize chemotherapy sensitization while precise chemotherapy is performed, and the therapeutic efficacy on pancreatic cancer is expected to be enhanced.

The invention belongs to the technical field of energy storage, and particularly relates to a method for modifying a zinc negative electrode interface by using silver nanowires, which comprises the following steps: step 1, dispersing the silver nanowires with high length-diameter ratio into an organic solvent at a certain concentration; step 2, performing ultrasonic cleaning on the zinc foil, and then coating the silver nanowire dispersion liquid prepared in the step 1 on the surface of the zinc foil; 3, the zinc foil coated with the silver nanowire dispersion liquid in the step 2 is dried, and the zinc foil attached with the silver nanowires is obtained; and 4, the silver nanowires attached to the zinc foil in the step 3 are subjected to hot welding, and the zinc foil coated with the silver nanowire interconnection network is obtained. The silver nanowire conductive network formed on the surface of the zinc foil enables the current to be uniformly distributed, so that the formation and growth of zinc dendrites are inhibited, and the electroplating / stripping cycle time of the zinc negative electrode is remarkably prolonged; and the silver nanowire conductive network can also adjust the interface property of the zinc negative electrode and the electrolyte, reduce the corrosion current and enhance the stability of the electrode.

The invention discloses a degradable polycarbonate cationic carrier and application thereof, and belongs to the technical field of drugs, the degradable polycarbonate cationic carrier is a nano-micelle formed by self-assembly of diblock polymers, the diblock polymers are represented as A-B, the A block is mPEG, and the B block is PAMA, PDMA or PDEA; the molecular weight of the block A is 2000 to 5000, and the polymerization degree of the block B is 50 to 150. The degradable polycarbonate cation carrier has an mRNA delivery function, and is combined with mRNA through a positive and negative electricity interaction principle, so that the problem of gene waste caused by mRNA loading through a microfluidic method can be solved, and efficient delivery of antigen presenting cells (APC) is realized.

The invention belongs to the technical field of drug carriers, and particularly discloses a preparation method and application of a closed-loop feedback-regulation nano drug delivery system.The preparation method comprises the following steps that a starting material containing a reversible molecular library is provided, and the reversible molecular library is prepared in a buffer salt system; under thermodynamic control, adding anti-cancer drug molecules and guest molecules into the starting material; through a reversible covalent reaction process, molecules in an initial material spontaneously form a self-assembled nano-carrier containing drug molecules under the combined action of the drug molecules and guest molecules. According to the preparation method and application of the closed-loop feedback-regulation nano drug delivery system, reversible covalent reaction, closed-loop feedback-regulation and self-assembly technologies are combined, spontaneous construction of a nano carrier is achieved, and the nano carrier is endowed with excellent drug loading capacity, stability and environmental responsiveness.

The utility model provides novel corrosion-resistant high-efficiency packing, which relates to the technical field of chemical packing and comprises a packing main body and a packing hoop, the packing hoop is arranged on the outer surface of the packing main body, an L-shaped splicing groove is formed in the side surface of the packing hoop, an installation screw hole is formed in the center of the surface of the packing main body, and a guide screen plate is arranged on the bottom surface of the installation screw hole. The two sets of filler bodies are arranged, the splicing assemblies are arranged between the adjacent filler bodies, the two ends of the splicing assemblies are connected with the L-shaped splicing grooves, the mounting studs are inserted into the mounting screw holes, and the adjacent filler bodies are spliced through the splicing assemblies, so that the two filler bodies form one set to be mounted and used, and a sandwich structure is formed for a gas-liquid path; the circulating time of gas and liquid in the tower is prolonged, the gas-liquid separation and flow guide efficiency is improved, meanwhile, the splicing assemblies composed of the filler plates are arranged for use, so that when the surface is damaged, rapid replacement can be achieved, the structure is simple, gas and liquid are treated through multiple channels, corrosion is prevented, and use in the chemical tower is facilitated.

The invention discloses an oligomeric amino acid dendritic macromolecular material as well as a preparation method and application thereof, and relates to the technical field of nano materials. The general formula of the oligomeric amino acid dendritic macromolecular material is TPE-(PEG) n-(Lys) x-(Arg) y, wherein TPE is a hydrophobic core, has an aggregation-induced emission characteristic, and can enhance the self-assembly capability and the tracing function of the nano-carrier; pEG is a connecting arm, so that the water solubility and biocompatibility of the material can be improved; lys is a branch skeleton and is a main construction unit of a dendritic macromolecule; arg is a functional terminal, guanidyl of Arg has strong positive charges, electrostatic binding with negatively charged nucleic acid can be promoted, and meanwhile cellular uptake can be enhanced possibly through the membrane penetration effect. The oligomeric amino acid dendritic macromolecular material gives consideration to stability, modifiability and targeting, provides a new scheme for small nucleic acid delivery, and is expected to have far-reaching influence in the fields of precise tumor treatment, gene therapy and multi-modal diagnosis and treatment.

The utility model belongs to the technical field of nitrogen-containing sewage treatment, and particularly relates to a short-range denitrification reactor which comprises a reaction tank, a cooling and stirring assembly is mounted in the reaction tank and comprises a coiled pipe, the two ends of the coiled pipe penetrate through the reaction tank and are rotationally connected with the reaction tank, and the cooling and stirring assembly is mounted in the reaction tank. The two ends of the coiled pipe are fixedly connected with rotating joints respectively; according to the sewage treatment device, the first driver drives the coiled pipe to rotate, so that stirring liquid is stirred, fusion of a medicament and sewage is accelerated, reaction is promoted, cold water in the water storage tank is guided into the coiled pipe by the circulating pump to form circulating flow, and then heat exchange with the sewage is performed when the coiled pipe rotates; when the coiled pipe rotates, the coiled pipe can be in full contact with the sewage in the reaction tank, and compared with the prior art, the cooling effect of the sewage in the reaction tank is integrally improved.

The invention discloses an application of a secretory curl-associated protein 2 gene as a new target for treating uterine scars, the secretory curl-associated protein 2 gene (sFRP2) promotes the progress of the uterine scars, interferes, silences and inhibits the uterine scars, and the sFRP2 is knocked out, so that the occurrence and development of the scar uterus can be relieved, the pregnancy rate of women can be increased, and the adverse pregnancy outcome can be reduced. In order to further improve the curative effect that sFRP2 gene expression is inhibited by sFRP2-targeted small interfering RNA (issFRP2) so as to inhibit uterine scar formation, ionizable lipid, distearoyl phosphatidylcholine (DSPC), cholesterol and 1, 2-dimyristoyl-rac-glycerol-3-methoxy polyethylene glycol (DMG-PEG) are mixed and dissolved in ethanol according to a certain molar ratio, issFRP2 is dissolved in a citric acid buffer solution, and the issFRP2-targeted small interfering RNA (issFRP2) is added into the citric acid buffer solution so as to obtain a mixed solution; an ethanol phase and a water phase are mixed through a microfluid device, and the mixed solution is dialyzed in a PBS solution for two hours to prepare lipid nanoparticles. And then mixing the polycarbophil, the poloxamer and the lipid nanoparticles to prepare the composite hydrogel. The hydrogel can locally release sisFRP2 in the uterus, inhibit fibrosis, reduce collagen deposition and repair uterine scars. The hydrogel is good in biocompatibility and noninvasive, can realize slow release of the medicine, avoids repeated administration, has no obvious side effect on a maternal body and a fetus, and can also be used for other fibrosis-related diseases.

The present invention discloses a tumor-targeting typhoid toxin B subunit mimetic peptide and its application. The typhoid toxin B subunit mimetic peptide is selected from any one of the six polypeptides YQPB-1: COOH-Thr-Gly-Ser-Gly-Asn-Ala-Asn-Val-NH2. The application of the typhoid toxin B subunit mimetic peptide or its dimer and multimer described in the present invention in the preparation of diagnostic reagents or tumor therapeutic drugs targeting tumors. The present invention has developed a series of new mimetic peptides that simulate the typhoid toxin B subunit (PltB) secreted by Salmonella typhi. The YQPB-X series of mimetic peptides can specifically bind to tumor cells with high expression of gangliosides. In vivo optical imaging and results have confirmed that they have excellent imaging results for various tumors such as neuroblastoma, non-small cell lung cancer, melanoma, breast cancer and osteosarcoma.

The invention discloses ultra-coarse tungsten carbide and a preparation method thereof, and the preparation method comprises the following steps: providing ultra-coarse tungsten oxide particles with the water content of 3-5 wt%, the average particle size of the ultra-coarse tungsten oxide particles being 28-45 [mu] m; loading the ultra-coarse tungsten oxide particles into a boat, placing the boat in a closed reduction furnace, introducing hydrogen, and carrying out a reduction reaction to obtain ultra-coarse tungsten particles; wherein the temperature of the reduction reaction ranges from 950 DEG C to 1100 DEG C, the boat loading amount ranges from 2.8 Kg / boat to 3.5 Kg / boat, the circulation time ranges from 45 min / boat to 60 min / boat, the hydrogen flow ranges from 8 m < 3 > / h to 15 m < 3 > / h, and the hydrogen dew point ranges from-65 DEG C to-75 DEG C; the ultra-coarse tungsten particles and carbon are mixed, and a carbon mixed material is obtained; performing high-temperature carbonization on the carbon-containing mixture to obtain tungsten carbide particles; the tungsten carbide particles are crushed and sieved, the ultra-coarse tungsten carbide is obtained, and the average particle size of the ultra-coarse tungsten carbide ranges from 30 micrometers to 60 micrometers. According to the method, the ultra-coarse tungsten particles with high purity and more uniform particle size distribution can be obtained.

This invention discloses nanoparticles that enhance the near-infrared II fluorescence of indocyanine green, their preparation method, and applications. The nanoparticles are prepared by mixing PLGA-PEG-PLGA and ICG-NHS. The specific method is as follows: S1, dissolve PLGA-PEG-PLGA in a solvent to form a first solution; S2, dissolve ICG-NHS in a solvent to form a second solution; S3, thoroughly mix the first and second solutions, react them, and remove unreacted substances by ultrafiltration to obtain the nanoparticles. The order of steps S1 and S2 is not limited. This invention enhances the emission of ICG through PLGA-PEG-PLGA, extending the application of ICG in the near-infrared II region to the NIR-IIa region (1300nm-1400nm), and effectively prolongs the circulation time of ICG in the blood, thus removing limitations in its application in fields such as tumor and vascular disease diagnosis.

The invention provides a tumor targeted nano drug delivery system and a preparation method and application thereof, the tumor targeted nano drug delivery system comprises a PD-L1 monoclonal antibody, radix pseudostellariae cyclic peptide B and an mPEG-PLGA-NH2 nano carrier, the radix pseudostellariae cyclic peptide B is encapsulated in the mPEG-PLGA-NH2 nano carrier, and the outer surface of the mPEG-PLGA-NH2 nano carrier is modified with the PD-L1 monoclonal antibody. The tumor-targeted nano drug delivery system has good anti-cancer activity and biocompatibility, has longer circulation time and higher bioavailability, is obviously superior to free drugs in the aspects of tumor resistance and immunoregulation, and is expected to be applied to preparation of tumor-targeted drugs, especially gastric cancer-targeted drugs.

The invention relates to the technical field of biological medicine, in particular to a shape memory nanocomposite as well as a preparation method and application thereof. The shape memory nano composite material comprises an anisotropic nano capsule and a photo-thermal material located in the anisotropic nano capsule, the anisotropic nano capsule is converted into a spherical nano capsule under illumination, and the material of the anisotropic nano capsule comprises a thermal response shape memory polymer. And the photo-thermal material is a biodegradable photo-thermal material. A biodegradable photo-thermal material is contained inside the anisotropic nanocapsule, and a cancer cell membrane can be adsorbed outside the anisotropic nanocapsule. Due to the anisotropy of the nanocapsule, the blood circulation time can be prolonged, meanwhile, the nanocapsule has the tumor targeting property, and the immune escape ability and the tumor targeting property of the nanocapsule are further improved through bionic modification of a cancer cell membrane. When reaching a tumor part, the near-infrared light can be utilized to realize intelligent shape transformation, so that cancer cell internalization is finally promoted, and the tumor photo-thermal treatment effect is improved.

The invention discloses an application of a magnetic resonance contrast agent in targeting the adrenal cortex. The magnetic resonance contrast agent is prepared by the following method: 18.5 mg of gadolinium trifluoromethanesulfonate, gadolinium chloride or gadolinium nitrate is weighed and dissolved in 2 ml of water, and then 2 ml of Na2CO3 / NaHCO3 buffer solution with a pH of 9-12 is added to precipitate it, and the precipitate is resuspended with water after centrifugation to form a suspension, and then human serum albumin or bovine serum albumin is dissolved in water, and is added dropwise to the suspension during shaking, and after adding a magnetic particle, the supernatant is centrifuged after stirring and reacting at 25-45°C, and finally the supernatant is ultrafiltered, concentrated and filtered with a 100K ultrafiltration tube to obtain a magnetic resonance contrast agent; the magnetic resonance contrast agent is used to target the adrenal cortex and can be taken up by macrophages in the adrenal cortex. The contrast agent has a mechanism for targeting the adrenal cortex, and the contrast agent is taken up by macrophages in the adrenal cortex. The magnetic resonance contrast agent can have a targeting enhancement effect on the adrenal cortex for at least 7 days.

The invention relates to a self-assembled modified polyolefin diaphragm as well as a preparation method and application thereof, and belongs to the technical field of electrochemistry. The technical problems that in the prior art, a polyolefin diaphragm is poor in thermal stability, mechanical performance and wettability, the side reaction of an electrode-diaphragm interface is serious, and dendritic lithium dendrites easily cause internal short circuit of a battery are solved. The preparation method of the self-assembled modified polyolefin diaphragm comprises the following steps: performing deposition modification of layered hydroxide on the surface of the polyolefin diaphragm through vacuum filtration to obtain a modified layer, and performing phase interface conversion on the modified layer through an electrochemical in-situ method to form a stable transition interface layer. The preparation method has the advantages of low production cost, simple operation process and the like, and the diaphragm prepared by the method has good thermal stability, mechanical property and chemical activity, can inhibit dendritic crystal growth to realize long-life cycle of the battery, and is suitable for large-scale production and industrial application.

The application discloses a pPAM long-circulating liposome, a preparation method and application thereof, and the long-circulating liposome takes a blank liposome as a carrier, internally carries a plasmid pPAM, and is decorated on the surface with a transferrin-penetratin complex Tf-Pen and an oxytocin receptor antibody OTR Ab； The plasmid pPAM carries a cDNA sequence of a peptide acylglycine alpha amidation monooxygenase PAM; and the blank liposome is composed of DSPC, PEG 2000 , cholesterol and lecithin. The application provides a new direction for development of endogenous polypeptide synthesis enzyme delivery technology and mental drugs, and improves the possibility of preparing new anti-anxiety and depression drugs, relieving mental stress and improving patient compliance.

The invention belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, and particularly relates to construction of albumin-bound adriamycin prodrugs and prodrug self-assembled nanoparticles and application of the albumin-bound adriamycin prodrugs and the prodrug self-assembled nanoparticles in preparation of antitumor drugs. The invention provides a novel albumin binding type adriamycin prodrug, self-assembled nanoparticles containing the prodrug are constructed, and the in-vivo circulation time of the drug is remarkably prolonged through specific binding of maleimide or acryloyl chloride and in-vivo albumin, so that tumor targeting of the drug is realized; meanwhile, the drug can be intelligently released in tumor cells due to the reduction-sensitive disulfide bond, the toxic and side effects on normal cells are reduced, and the drug has a wide clinical transformation prospect.

The invention relates to a lung selective biomacromolecule delivery system as well as a construction method and application thereof, and belongs to the field of biomedical materials. The biomacromolecule delivery system disclosed by the invention comprises a biomacromolecule compound, wherein the biomacromolecule compound is a polymer; the biomacromolecular compound is obtained by self-assembly of a metal-organic cage, polyethylene glycol, polyethyleneimine and a biomacromolecular drug. The delivery system disclosed by the invention has efficient lung selectivity on an active matter level, and the bioavailability of a biomacromolecular drug in lung tissues is remarkably improved, so that the delivery system has good safety and wide application prospects.

This invention discloses a liposome, a drug-loaded liposome, its preparation method, and its applications. The liposome comprises a liposome backbone and a targeting ligand; wherein the liposome backbone comprises the following components: phospholipids, cholesterol, cationic lipids, and PEGylated phospholipids; the cationic lipids are (2,3-dioleoyl-propyl)-trimethylammonium chloride and / or 1,2-dioleoyl-3-trimethylammonium propane; and the targeting ligands are sodium hyaluronate and / or hyaluronic acid. This liposome possesses excellent basic properties and excellent targeting ability; after encapsulating the active pharmaceutical ingredients (doxacin hydrochloride and berberine hydrochloride), its targeting ability can be further enhanced in practical applications, thereby increasing its efficacy.

The invention provides a milk exosome coated PLGA (poly (lactic-co-glycolic acid)) nano antituberculosis drug system as well as preparation and application thereof. The structure of the system is as follows: anti-tuberculosis drug-milk exosome-coated PLGA-anti-tuberculosis drug. The antituberculous drug is selected from one or a combination of more of aminoquinolones, benzothiazoles, aryl quinoline, nitrobenzamides and benzothiazinone antituberculous drugs. According to the nano antituberculosis drug system, the circulation time of nano particles in blood is prolonged, and the bioavailability of the drug is improved. The cellular uptake efficiency of the nanoparticles is enhanced, and the drug delivery effect is improved. The immunological rejection and the potential toxicity are reduced, and the treatment safety is improved.

The invention relates to the field of cancer treatment, and particularly discloses a synthetic method and application of a dual-response bimetallic nano-catalyst, and the synthetic method comprises the following steps: 1, synthesizing CuFeMOF nanoparticles; (2) synthesizing CuFeMOF (at) GOx nano particles; step 3, synthesizing a CuFeMOF (at) GOx (at) Mem) nano particle structure catalyst; under the action of an erythrocyte membrane, after the CuFeMOF (at) GOx (at) Mem is accumulated in a tumor tissue, GOx catalyzes glucose to generate H2O2 and gluconic acid, the gluconic acid aggravates reduction of PH in the tissue, the CuFeMOF (at) GOx (at) Mem is further activated to release Fe < 3 + > and Cu < 2 + >, then the Fe < 3 + > and the Cu < 2 + > are converted into Fe < 2 + > and Cu < + > by GSH, and Fe < 2 + >-mediated Fenton reaction is activated; in addition, Cu < + > can further promote conversion from Fe < 3 + > to Fe < 2 + >, and the CDT (chemodynamic therapy) effect is enhanced. The capacity of continuously accumulating Fe < 2 + > and eliminating GSH is shown through the amplification effect among GSH, Fe and Cu ions. In conclusion, according to the nano system, the effect of the CDT is greatly improved through a triple regulation mechanism of H2O2 self-supply, catalyst self-circulation and GSH self-elimination, and a unique method is provided for improving the anti-tumor potential of the CDT.

The invention discloses a hybrid cell membrane disguised hexagonal boron nitride nano-particle as well as a preparation method and application thereof, relates to the technical field of medicines, and aims to solve the problems of poor targeting property and biocompatibility of a boron carrying agent, insufficient in-vivo stability and tumor accumulation capacity of nano-particles and the like in BNCT tumor treatment in the prior art. The composite material comprises hexagonal boron nitride nanoparticles and a hybrid cell membrane coating the peripheries of the hexagonal boron nitride nanoparticles, and the hybrid cell membrane is formed by fusing a macrophage cell membrane and a tumor cell membrane. The targeting property and biocompatibility of the boron carrying agent and the in-vivo stability and tumor accumulation capacity of nanoparticles can be effectively enhanced, and the BNCT treatment effect of glioma is improved.