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Folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as preparation method and application thereof

The invention relates to a folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as a preparation method and application thereof. The delivery carrier is prepared by taking anamphiphilic triblock copolymer PCL-ss-PEG-ss-PCL as a material, and a chemotherapeutic drug adriamycin amycin and a photosensitizer indocyanine green are entrapped in a hydrophobic core of the micelle. Besides, phospholipid DSPE-PEG-NH2 with an active group is introduced into the preparation process, the DSPE end of the phospholipid has strong hydrophobic property and is inserted into the hydrophobic PCL core of the polymer micelle, the flexible hydrophilic PEG long chain exists on the outer surface of the micelle, FA with a targeting effect is connected to a PEG active distal end of the surface of the polymer micelle, and functions of active tumor targeting and reduction response drug release are integrated. The folate-targeted reduction sensitive drug-carrying polymer nano-micelle disclosed by the invention has the advantages of being small in particle size, high in dispersion property, high in drug loading capacity and encapsulation efficiency and excellent in photothermal conversion effect, can realize reduced trigger drug release, fluorescence imaging of tumor sites, tumor targeting drug delivery and chemotherapy-photothermal combination therapy and improve the tumor inhibition effect, and has wide application prospects in the targeted combination therapy aspect of tumors.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

System and method for optimized property retrieval of stored objects

A system and related techniques generate an interrogation request from an initiator device, such as a client desktop machine or other machine, to a mobile or other media player, such as a digital camera, MP3 player, video camera or other device or hardware to enumerate the media content contained in that device, along with associated properties. The collection of binary objects which encode the content, such as digital photographs, encoded audio files, digitized video or other media, may include or have associated with them a set of corresponding object properties which help to define each object, such as by defining a pixel color depth, audio codec or other property or attribute. According to embodiments of the invention, the initiator may communicate with the responding device using a media-aware protocol supporting an aggregate object property request, such that the initiator may identify one or all of the set of properties paired with all of the objects to be returned along with an enumeration of those objects. The initiator may then present, for example, a list of song titles along with the corresponding artist, track length, codec, display skins or other attributes or properties to a user, for example to select, delete, copy or otherwise manipulate the underlying objects, which may in one regard be separately retrieved from their identifier and properties. Because properties may be retrieved in conjunction with, at the same time and using a unified retrieval scheme, the need to query each object identifier one by one for associated properties is removed. The throughput and responsiveness of object property retrieval is therefore significantly enhanced.
Owner:MICROSOFT TECH LICENSING LLC

PH/reduction dual-sensitive multifunctional nano-micelle for tumor chemotherapy and photothermal combined therapy and application of pH/reduction dual-sensitive multifunctional nano-micelle

InactiveCN108354901AReduction-sensitiveWith pH/reduction smart responsivenessOrganic active ingredientsEnergy modified materialsDispersityTumor target
The invention relates to a pH / reduction dual-sensitive multifunctional nano-micelle for tumor chemotherapy and photothermal combined therapy and application of the pH / reduction dual-sensitive multifunctional nano-micelle. The pH / reduction dual-sensitive multifunctional nano-micelle is characterized in that a PCL-acetal-PEG polymer with pH sensitive characteristic, a PCL-ss-PEG-ss-PCL polymer withreduction sensitive characteristic and a phospholipid DSPE-PEG-NH2 with an active group are used as raw materials and are blended to prepare a pH / reduction intelligent responsive polymer nano-micelleas a carrier; a chemotherapeutic drug and a photosensitizer coat a hydrophobic core of the micelle; a casing is made of hydrophilic PEG and has the characteristic of long circulation and space stability; a folic acid targeting group is modified on the surface of the micelle by a covalent bond; the drug loading capacity is 4 to 10 percent, and the mass ratio of the chemotherapeutic drug to the photosensitizer is 0.5 to 2; the particle size is smaller than 200 nm. The pH / reduction dual-sensitive multifunctional nano-micelle disclosed by the invention has the advantages of good dispersity, smallparticle size, better photothermal conversion effect and high drug loading capacity and encapsulation efficiency; the effect of improving tumor suppression by tumor targeted administration, fluorescence imaging of a tumor site, pH / reduction triggered drug release and chemotherapy and photothermal combined therapy can be realized; the pH / reduction dual-sensitive multifunctional nano-micelle has a broad clinical application prospect in combined targeting therapy of tumors.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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