Folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as preparation method and application thereof

A drug-loaded polymer and folic acid targeting technology, which is applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problems of tumor cell recurrence or metastasis, uneven heat distribution, and difficulty in killing cancer cells, and achieve the goal of overcoming In vivo instability and ease of clearance, prolongation of circulation time, effects of long circulation properties
CN108478531AInactive Publication Date: 2018-09-04INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Publication Date
2018-09-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a folate-targeted reduction sensitive drug-carrying polymer nano-micelle as well as a preparation method and application thereof. The delivery carrier is prepared by taking anamphiphilic triblock copolymer PCL-ss-PEG-ss-PCL as a material, and a chemotherapeutic drug adriamycin amycin and a photosensitizer indocyanine green are entrapped in a hydrophobic core of the micelle. Besides, phospholipid DSPE-PEG-NH2 with an active group is introduced into the preparation process, the DSPE end of the phospholipid has strong hydrophobic property and is inserted into the hydrophobic PCL core of the polymer micelle, the flexible hydrophilic PEG long chain exists on the outer surface of the micelle, FA with a targeting effect is connected to a PEG active distal end of the surface of the polymer micelle, and functions of active tumor targeting and reduction response drug release are integrated. The folate-targeted reduction sensitive drug-carrying polymer nano-micelle disclosed by the invention has the advantages of being small in particle size, high in dispersion property, high in drug loading capacity and encapsulation efficiency and excellent in photothermal conversion effect, can realize reduced trigger drug release, fluorescence imaging of tumor sites, tumor targeting drug delivery and chemotherapy-photothermal combination therapy and improve the tumor inhibition effect, and has wide application prospects in the targeted combination therapy aspect of tumors.
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Description

technical field

[0001] The invention relates to a folic acid-targeted reduction-sensitive drug-loaded polymer nanomicelle and its preparation method and application, in particular to a targeted polymer micelle mediated by folic acid and capable of reducing the response to the tumor microenvironment, which can efficiently The inner core of the polymer micelle contains chemotherapeutic drugs and photosensitizers, and has long-term circulation characteristics, can enter tumor cells efficiently, and realizes reduction-sensitive triggered drug release and combined chemotherapy-photothermal therapy of tumors. Background technique

[0002] Polymer micelle was developed 30 years ago. It is a thermodynamically stable colloidal solution formed by spontaneous assembly of amphiphilic polymers in selective solvents due to intermolecular hydrogen bonds, electrostatic interactions and van der Waals forces. A shell structure in which the hydrophilic blocks form the outer shell and the hydro...

Claims

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