160 results about "Indocyanine green" patented technology

The preparation method comprises the following steps: synthesizing gold nanostars (GNS) by using a seed growth method, coating mesoporous cerium dioxide (mCeO2) by using a template method, and loading a photosensitizer indocyanine green (ICG), so as to form a nano enzyme diagnosis and treatment system with chemical activity, photoactivity and photothermal effects. In the system, the gold nanostars have a good photo-thermal effect due to the multi-branched structure of the gold nanostars; on one hand, the mesoporous cerium dioxide coated on the outer layer has a chemical effect due to the nano-enzyme effect, and on the other hand, the mesoporous structure of the mesoporous cerium dioxide can better load the photosensitizer indocyanine green. All the components have good stability and biological safety, also have peroxidase simulation activity and a drug loading function, can improve the level of reactive oxygen species (ROS) in a tumor microenvironment and load photosensitizer drugs, and have an excellent anti-tumor effect and small side effects.

The invention relates to a gadolinium-doped carbon dot complex based on liver cancer cell membrane coating and a preparation method of the gadolinium-doped carbon dot complex. The gadolinium-doped carbon dot complex is prepared on the basis of gadolinium-doped carbon dots Gd-CDs which are prepared from indocyanine green, citric acid, polyethylene glycol and gadolinic acid through a one-step microwave thermal method and have fluorescence-magnetic resonance bimodal imaging capacity. The Gd-CDs complex Gd-CDs coated HCM is placed in a cell membrane suspension extracted from human hepatoma carcinoma cells HepG2, and the Gd-CDs complex Gd-CDs coated HCM which is uniform in particle size and has the capacity of photothermal and immunotherapy of hepatocellular carcinoma is obtained through extrusion construction of a liposome extruder. The Gd-CDs (at) HCM complex constructed by the invention not only has good bimodal imaging ability, but also has a specific inhibition effect on liver tumor cells, can be applied to preparation of drugs for inhibiting the growth of the liver tumor cells, and realizes a good treatment effect on liver cancer at a nanometer level.

The invention belongs to the technical field of nano biological medicines, and particularly relates to injectable organic composite hydrogel combined with photo-thermal chemotherapy as well as a preparation method and application thereof. The injectable organic composite hydrogel combined with photo-thermal chemotherapy is composed of an orthoester compound and a water-phase hydrogel, the orthoester compound is emulsified and then uniformly dispersed in the hydrogel, and the hydrogel is formed by crosslinking carboxymethyl chitosan and glutaraldehyde. In the injectable organic composite hydrogel combined with photo-thermal chemotherapy provided by the invention, firstly, oily orthoester is utilized to dissolve a cis-platinum prodrug and indocyanine green to obtain an orthoester compound, then the orthoester compound is uniformly emulsified and loaded in the hydrogel, dynamic imine bonds of the hydrogel respond to tumor slightly acidic environment breakage, and then the dynamic imine bonds of the hydrogel are separated from the dynamic imine bonds of the hydrogel, so that the injectable organic composite hydrogel combined with photo-thermal chemotherapy can be used for preparing the injectable organic composite hydrogel combined with photo-thermal chemotherapy. The orthoester compound successfully escapes, along with degradation of the oily orthoester, the cis-platinum prodrug and the indocyanine green are self-assembled through hydrogen bonds to form nanoparticles, the enrichment and retention capacities of the two drugs at the tumor site are enhanced, and the overall curative effect is improved.

The invention relates to the technical field of tumor fluorescence contrast agents, and particularly provides a conjugate of indocyanine green and multi-arm polyethylene glycol or pharmaceutically acceptable salt of the conjugate and a preparation method and application of the conjugate, the conjugate has the structural formula shown in the formula (I), the binding capacity of the conjugate and serum protein is remarkably reduced, and the conjugate can be applied to tumor fluorescence contrast agents. According to the present invention, the tumor targeting property is significantly improved, and the tumor is accumulated and detained in the tumor tissue, such that the targeted treatment or the high-resolution imaging is achieved so as to achieve the accurate tumor positioning and diagnosis, the high application value is provided, and the new method is developed for the tumor imaging and the treatment.

The invention discloses a multifunctional tumor targeted low-temperature treatment nano platform and application thereof, and belongs to the technical field of nano biological medicines. According to the multifunctional tumor targeted low-temperature treatment nano platform, the two-dimensional Ti3C2 nano material serves as a carrier, indocyanine green is loaded to serve as a photosensitizer, polydopamine is modified on the surface to improve the stability, and gambogic acid is loaded to serve as an anti-tumor drug and a heat shock protein inhibitor; and a nucleic acid aptamer capable of recognizing specific protein on the cell surface is coupled in a covalent binding manner. The multifunctional tumor targeted low-temperature treatment nano platform is small in particle size, high in dispersion degree and good in biocompatibility, and shows excellent photo-thermal conversion capacity, photodynamic treatment effect and chemotherapy effect in tumor targeted treatment. The apoptosis of tumor cells can be effectively induced under a relatively low temperature condition, and the damage of high temperature to surrounding healthy tissues is remarkably reduced. The tumor focus specific recognition capability is also realized, the high enrichment at the tumor part can be realized, and the treatment effect is enhanced.

The invention belongs to the technical field of photodynamic therapy, and particularly relates to a BODIPY compound, a preparation method and application of the BODIPY compound as a photosensitizer. The invention provides a series of novel-structure small molecule compound photosensitizers which take BODIPY dimers as basic frameworks and are pure I-type photodynamic. Under the combined action of a heavy atom introduced at a specific position, 2, 4, 6-trimethylphenyl and a defined structure R group, the yield of active oxygen is improved, and the regulation and control of the pure I-type photosensitizer are performed by regulating and controlling the energy level. Compared with a common photosensitizer molecule indocyanine green (ICG), the active oxygen yield is about 50 times that of ICG, higher photo-thermal stability is achieved, the applicability of a photodynamic reagent can be remarkably improved, the preparation method is simple, the reaction efficiency is high, the yield is high, and good industrial application prospects are achieved.

The present invention discloses a pH / GSH program-responsive photothermal nanocomposite hydrogel co-drug-carrying system and a preparation method and application thereof, and belongs to the field of anti-tumor materials. The nanocomposite hydrogel co-drug-carrying system of the present invention is a pH-sensitive chitosan hydrogel co-carrying GSH stimulus-responsive drug-carrying nanoparticles encapsulated by hyaluronic acid and indocyanine green. The drug-carrying nanoparticles encapsulate tyrosine kinase inhibitors, and the chitosan hydrogel is obtained by cross-linking chitosan with polyethylene glycol-4-formylbenzoic acid. The nanocomposite hydrogel is easy to administer in situ, and the photothermal conversion of indocyanine green under near-infrared light irradiation is used to accurately thermally ablate the primary tumor; at the same time, the drug-carrying nanoparticles escape from the gel, respond to the release of the loaded tyrosine kinase inhibitor by GSH in the tumor cells, and inhibit tumor recurrence and metastasis. The nanocomposite hydrogel can achieve chemotherapy-photothermal synergistic therapy, enhance the therapeutic effect on tumors and reduce toxic side effects.

The present invention relates to a fluorescent compound based on new indocyanine green IR820 and its preparation and application. The molecular structure of the fluorescent compound is shown in formula (1): Compared with the prior art, the fluorescent probe of the present invention has near-infrared fluorescence emission, good tumor targeting, biocompatibility, low cytotoxicity, and strong biological tissue penetration. It can be used for targeted fluorescence imaging of tumor cells and living tumors, and is expected to be further used in fluorescence surgical navigation.

The invention discloses a water-soluble fibroin-novel indole cyan green nano particle and a preparation method and application thereof, biocompatible silk fibroin and small photo-thermal molecules of novel indole cyan green dye are integrated together, and the water-soluble fibroin-novel indole cyan green nano particle expressed as SF (at) IR820 is obtained. The SF (at) IR820 prepared by the invention can go deep into tumor cells. The SF (at) IR820 can effectively eliminate 4T1 tumor cells in vitro and inhibit tumor growth in vivo when exposed to 808nm laser radiation, a promising strategy is provided for developing an efficient photothermal agent for cancer treatment, and the SF (at) IR820 has certain reference significance and application value.

The utility model discloses an indocyanine green precise puncture and injection device under a laparoscope, which belongs to the field of medical instruments and comprises a needle tube outer cylinder, a middle propelling device arranged in the needle tube outer cylinder, an internal propelling device arranged in the middle propelling device, a negative pressure drainage piece arranged at the head of the needle tube outer cylinder, and a negative pressure drainage piece arranged at the tail of the needle tube outer cylinder. An outer hose is arranged at the other end of the negative pressure drainage piece, a suction cup head is arranged at the other end of the outer hose, an inner hose is arranged at the head of the middle propelling device, the inner hose penetrates through the negative pressure drainage piece and then extends into the outer hose, an injection needle is arranged at the head of the inner hose, and an electrocoagulation wire is arranged in the suction cup head and connected with the injection needle. According to the utility model, an operator can accurately complete puncture and injection operations under a laparoscope; the problem that when indocyanine green is injected, a needle is withdrawn and after the needle is withdrawn, the medicament overflows to pollute the tissue surface is solved; electric coagulation hemostasis can be implemented in the whole operation process; and the medicine injection dosage can be controlled more accurately.

The invention discloses a ZIF-8 composite material loaded with SSZ and ICG as well as a preparation method and application thereof, and belongs to the field of nano medicine. The preparation method comprises the following steps: mixing salazosulfapyridine, indocyanine green and zinc nitrate hexahydrate to obtain a mixed solution; adding 2-methylimidazole into the mixed solution, and stirring to generate ZIF-8 nanoparticles loaded with salazosulfapyridine and indocyanine green; removing uncombined impurities in the ZIF-8 nano-particles by means of centrifugation and washing, so as to obtain the ZIF-8 composite material loaded with SSZ and ICG; in the ZIF-8 synthesis process, indocyanine green and salazosulfapyridine are entrapped at the same time through a co-dissolution method, and compared with traditional'post-loading 'or'multi-step entrapment', the technological process is greatly simplified, and the drug entrapment efficiency and structural stability are improved; meanwhile, the composite material has good biocompatibility and enhanced cytotoxicity in breast cancer cells, and a novel efficient strategy is provided for combined treatment of breast cancer.

The invention discloses a near-infrared fluorescent probe based on magnesium boride, a probe product as well as a preparation method and application of the near-infrared fluorescent probe. The near-infrared fluorescent probe based on magnesium boride is of a pH response type and is prepared by a method comprising the following preparation steps: (1) completely dissolving indocyanine green and polyvinylpyrrolidone in a solution to obtain a mixed solution; (2) keeping the mixed solution obtained in the step (1) away from light and continuously mixing for preset time; (3) adding magnesium boride into the system in the step (2), and continuously mixing the system in a preset time under a dark condition, so that the magnesium boride is combined with the indocyanine green and the polyvinylpyrrolidone; (4) centrifuging the solution obtained in the step (3) at 200-300rmp, and taking supernate; then, centrifuging the supernate at the speed of more than or equal to 12,000 rmp, and taking precipitate; and (5) obtaining a powder product from the precipitate obtained in the step (4), thereby obtaining the near-infrared fluorescent probe based on magnesium boride.

The present application relates to an antifungal microneedle patch and its preparation method and application, the antifungal microneedle patch includes backing layer and the needle head arranged on the surface of the backing layer;The needle head constitutes n×n array on the surface of the backing layer;The surface of the needle head includes fatty acid coating containing antibacterial drug;The inside of the needle head includes photosensitizer;The n is selected from integer.The antibacterial drug is lipophilic triazole antifungal drug.The fatty acid is selected from saturated fatty acid containing 6-12 carbon atoms.The present application innovatively combines antifungal drug itraconazole and photo-thermal agent / photosensitizer indocyanine green, loads in microneedle, can carry out painless minimally invasive local administration, through the antibacterial action, photo-thermal effect and photodynamic effect of antifungal drug released under the excitation of near-infrared light, realize the effective killing to fungi, and will not cause irreversible damage to normal tissue.

A flexible near-infrared II region photodetector based on two-dimensional material nanoribbons relates to the technical field of optoelectronic devices, and solves the problems of poor flexibility and low responsivity of existing near-infrared II region photodetectors. It includes: a flexible substrate; an inorganic nanoribbon array disposed on the upper surface of the flexible substrate; a metal electrode disposed on the upper surface of the inorganic nanoribbon array; an organic modification layer connecting the inorganic nanoribbon array, and the near-infrared II region spectral absorption rate of the organic modification layer is not lower than that of methylene blue, porphyrin compounds or indocyanine green in the near-infrared II region. The preparation method is: preparing an inorganic nanoribbon array on the flexible substrate; preparing an organic modification layer on the inorganic nanoribbon array. The present invention improves the optoelectronic conversion efficiency of the device through the energy band distribution and coupling between two-dimensional organic and inorganic materials; improves the responsivity of the device in the near-infrared II region; can be attached to the surface of a living body for real-time detection of a moving living body.

The invention relates to the technical field of medical instruments, in particular to a laparoscopic indocyanine green injection needle which comprises an injection part, an infusion tube, a clamping part and a needle head, the injection part is used for injecting indocyanine green, one end of the infusion tube is connected with the injection part, the other end of the infusion tube is connected with the clamping part, and the needle head is connected with the clamping part so that the injection part, the infusion tube, the clamping part and the needle head can be communicated. When indocyanine green is injected into the injection part, the indocyanine green can flow out of the needle head through the injection part, the infusion tube and the clamping part in sequence, and the clamping part is used for being clamped by operating forceps. According to the indocyanine green injection needle used under the laparoscope, the step that a fixed wing is removed by using a traditional needle head is omitted, inconvenience and risks caused by automatic trimming are avoided, the risk that an object falls off due to the fact that a fixed wing rubber block is cut off is avoided, the operation difficulty of indocyanine green injection in a laparoscopic surgery is reduced, and the operation efficiency is improved. And the operation process is simpler, more convenient and safer.

The application discloses a kind of nanomotor composite material with eccentric core-echinus shell structure and its preparation method and application, the nanomotor composite material has core-shell structure, its core is made of carbon material, it is filled between core-shell by indocyanine green and staphylolytic enzyme material and is constituted, shell is SiO2@carbon material and is constituted, with echinus porous structure, and indocyanine green and staphylolytic enzyme are loaded on surface;The core of the shell does not coincide with the ball center.The nanomotor composite material of the application is irradiated under the NIR, and it is combined with photosensitizer ICG and carbon material in material, and its asymmetric eccentric structure can make composite material uneven heating, produce self-heating driving force, realize staphylolytic enzyme and ROS for MRSA biofilm targeted action.The nanomotor is applied to preparation of drug for promoting diabetic wound healing, has excellent tissue penetration capacity and drug efficiency, and shows efficient synergistic antibacterial performance.

The present invention belongs to the field of photodynamic therapy technology, and more particularly to a BODIPY compound, a preparation method and its use as a photosensitizer. The present invention provides a series of novel small molecule compound photosensitizers with BODIPY dimer as basic skeleton and pure type I photodynamic. By the combined action of heavy atoms, 2,4,6-trimethylphenyl groups and limited structure R groups introduced at specific positions, the reactive oxygen species yield is increased, and the regulation of pure type I photosensitizer is carried out by regulating energy levels. Compared with common photosensitizer molecule indocyanine green (ICG), the reactive oxygen species yield is about 50 times that of ICG, has higher photothermal stability, can significantly increase the applicability of photodynamic agents, and the preparation method is simple, the reaction efficiency is high, the yield is high, and there is good industrial application prospect.

The application relates to a synthesis method of red luminescent carbon dots with a targeting diagnosis and treatment potential of hepatocellular carcinoma, which comprises the following steps: 1) adding 5-fluorouracil and indocyanine green into deionized water, uniformly mixing, and forming a uniform mixed solution; 2) heating the mixed solution obtained in the step 1) at 160-200 DEG C for 5-9 h, and cooling to room temperature; 3) filtering and dialyzing the solution obtained in the step 2), and obtaining a pure 5-FICD solution; and 4) freeze-drying the solution obtained in the step 3), and obtaining the product. The method takes anticancer drug 5-fluorouracil and photosensitizer indocyanine green as precursors, synthesizes a low-toxicity red light carbon dot through a simple hydrothermal method, improves the shortcoming that a chemotherapy drug has a large side effect, and realizes the targeted killing of hepatocellular carcinoma cells.

The utility model relates to a fluorescence camera shooting bayonet and an endoscope system. The fluorescence camera shooting bayonet is sequentially provided with a front protection sheet, an optical lens group and a band elimination optical filter in the direction from the object side to the image side. The plane where the band-stop optical filter is located intersects with the plane where the front protection sheet is located. According to the three-dimensional endoscope, the distortion is small, an MTF modulation function tends to the diffraction limit, the maximum radiuses of imaging confusion spots in different view fields are all within the Airy spot radius range, the three-dimensional endoscope can achieve clear imaging within the wide waveband range, ghost images of the endoscope are eliminated, and observation and operation convenience of a user is improved; a prism model is further added, and endoscope visible light imaging and endoscope ICG (indocyanine green) fluorescence imaging can be simultaneously carried out by using a fluorescence camera shooting bayonet.

The invention discloses a load ICGamp. The invention discloses ZIF-8 nano-particles of CBF, and belongs to the technical field of preparation of nano-drug particles. The multifunctional nanoparticles are formed by simultaneously encapsulating indocyanine green (ICG) and cinobufagin (CBF) components by ZIF-8, and the drug loading capacities of the two drugs are both not lower than 5%. The preparation method comprises the following steps: slowly adding a solution containing cinobufagin and zinc nitrate into a mixed solution containing indocyanine green, bovine serum albumin and 2-methylimidazole, and carrying out centrifugal filtration, washing and drying on a reaction product to obtain the cinobufagin zinc oxide. The multifunctional nano-particles prepared by a one-step synthesis method are uniform in particle size and good in stability, indocyanine green and cinobufagin are uniformly distributed in a carrier, the multifunctional nano-particles have pH and near-infrared light dual response drug release characteristics, triple synergy of chemotherapy, photothermal therapy and photodynamic therapy can be realized, and the multifunctional nano-particles are simple in preparation process and suitable for popularization and application.

This invention discloses a multifunctional tumor-targeted cryotherapy nanoplatform and its applications, belonging to the field of nanobiomedicine technology. The multifunctional tumor-targeted cryotherapy nanoplatform of this invention uses two-dimensional Ti3C2 nanomaterials as a carrier, loaded with indocyanine green as a photosensitizer, surface-modified with polydopamine to improve stability, and loaded with gambogeylic acid as an anti-tumor drug and a heat shock protein inhibitor. It is covalently coupled with nucleic acid aptamers that can recognize cell surface-specific proteins. The multifunctional tumor-targeted cryotherapy nanoplatform has small particle size, high dispersion, and good biocompatibility, and exhibits excellent photothermal conversion ability, photodynamic therapy effect, and chemotherapy effect in tumor-targeted therapy. It can effectively induce tumor cell apoptosis under relatively low temperature conditions, significantly reducing the damage of high temperature to surrounding healthy tissues. It also has the ability to specifically recognize tumor lesions, achieving high enrichment at the tumor site and enhancing the therapeutic effect.

The invention belongs to the technical field of antibacterial photodynamics, and provides antibacterial photodynamics for treating periodontitis by regulating ROS (reactive oxygen species) through microenvironment response and a preparation method of the antibacterial photodynamics. Comprising the following steps: preparing tin sulfide oxide by taking sodium dodecyl benzene sulfonate, tin chloride pentahydrate and L-cysteine as raw materials; zinc nitrate, copper nitrate, urea and thioacetamide are used as raw materials to prepare nano-enzyme; the antibacterial photodynamic material is prepared by taking indocyanine green, bacterial targeting peptide, nano enzyme, tin sulfide oxide and dihydromyricetin as raw materials. The microenvironment response antibacterial photodynamic force aiming at periodontitis infection and treatment characteristics is constructed, the antibacterial photodynamic force is constructed by a strategy of combining bacterial infection microenvironment response ROS programmed regulation and control, precise and long-acting treatment and immune regulation and control, and the curative effect and scene of the antibacterial photodynamic force for treating periodontitis are improved and widened.

The invention relates to a high-sensitivity treatment-free negative image CTP plate material and a preparation method thereof, and belongs to the technical field of CTP plate materials, the treatment-free negative image CTP plate material comprises a plate base and a photosensitive layer, the photosensitive layer contains a modified graphene oxide composite material, the modified graphene oxide composite material can promote rapid conduction of heat, strengthen scratch resistance and improve the sensitivity of the photosensitive layer, and the modified graphene oxide composite material is essentially formed by compounding an infrared absorption dye new indocyanine green onto nitrogen-aluminum co-doped graphene oxide, so that the infrared absorption dye new indocyanine green can be effectively absorbed by the nitrogen-aluminum co-doped graphene oxide; the specific preparation method comprises the following steps: doping nitrogen and aluminum elements in graphene oxide by using urea and aluminum nitrate nonahydrate to prepare nitrogen-aluminum co-doped graphene oxide, and then adding amino-modified new indocyanine green to react by taking dehydration esterification as a reaction principle, thereby obtaining the nitrogen-aluminum co-doped graphene oxide. The amino-modified novel indocyanine green is prepared from a short-carbon-chain diamine compound and novel indocyanine green under the action of amino and halogen.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to an indocyanine green preparation and a preparation method and application thereof. The preparation is a liquid preparation or a freeze-dried preparation, raw materials for preparing the preparation include indocyanine green, phospholipid, cholesterol, a freeze-drying protective agent, water and a pH regulator, the pH regulator is selected from one or more of sodium citrate, potassium citrate, sodium tartrate, sodium acetate, sodium lactate and sodium succinate, and the pH of the preparation is adjusted to 6.0-8.5. By means of a specific organic acid salt buffer system and a specific preparation process (the freeze-drying protective agent is added before lipid film deposition), the application can specifically inhibit the growth of impurities with RRT 0.7 and RRT 0.3, respectively, and significantly improve the chemical stability of the preparation. Meanwhile, the preparation can realize accurate positioning of sentinel lymph nodes and second and third lymph nodes, and can be used for preparing a lymph tracer. The application effectively solves the technical problems of rapid impurity growth, poor stability and inaccurate multi-stage lymph positioning of the existing ICG preparation.

The invention belongs to the field of medical treatment, and relates to a modeling method and system of a clinical significant portal hypertension risk assessment model, the method comprises the following steps: step 1: obtaining patient detection index data, the patient detection index comprising a 15-minute retention rate of indocyanine green measured by a pulse dye density method; the patient detection index data is divided into a training set and a verification set; the training set and the verification set both comprise clinical significant portal hypertension patient data and non-bed significant portal hypertension patient data; and 2, establishing a clinical significant portal hypertension risk assessment model by using the training set and the verification set based on the 15-minute retention rate of indocyanine green measured by a pulse dye density method.

The present disclosure relates to an apparatus and method for early evaluation of lymphedema occurrence by determining the regularity of lymphatic contractions, the apparatus comprising a memory for storing at least one instruction for early evaluation of lymphedema occurrence, and a processor for performing operations according to the instruction, wherein the processor: monitors, by using indocyanine green lymphography, the occurrence of lymphedema in an animal model in which lymph nodes have been resected to disconnect lymphatic circulation in an upper limb from the proximal region; measures lymphatic contraction signals at a distal site to detect the onset of and changes in lymphatic circulation disorder; compares the measured lymphatic contraction signals with the lymphatic contraction signals from a normal site; monitors changes in the lymphatic contraction signals at the distal site; and determines the presence of lymphedema on the basis of the monitoring results.

The invention aims to provide a preparation method and application of a gouty arthritis microenvironment response type diagnosis and treatment integrated nanoprobe, and belongs to the technical field of biomedical nanomaterials. Natural tea extract tea polyphenol is used as a raw material, polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer is used as a template, a soft template method is utilized, and the gouty arthritis microenvironment response type diagnosis and treatment integrated nanoprobe is prepared. And stirring, centrifuging and freeze-drying to synthesize the mesoporous tea polyphenol nano-particles. Meanwhile, indocyanine green with fluorescence emission in a near-infrared second region and a steroid anti-inflammatory drug dexamethasone are connected to the two ends of an active oxygen response type ketal thiol bond respectively, and the active oxygen response type nano-particles are synthesized through stirring, dialysis and freeze drying. And finally, loading the response type nano-particles in mesoporous tea polyphenol by a solvent impregnation method to realize anti-inflammatory and anti-oxidation treatment of gouty arthritis at different stages.

The present invention relates to an enhanced sonodynamic therapeutic agent using a liposome having the ability to transfer oxygen, and more particularly, to lipid nanoparticles having the ability to transfer oxygen in which perfluorocarbon (PFC) and indocyanine green (ICG) are loaded inside liposomes to increase the efficiency of sonodynamic therapy.

The present application provides a kind of hydrogel dressing with photothermal / photodynamic synergistic antibacterial activity and its preparation method, belong to biological medical tissue engineering material technical field, the present application is by the indocyanine green (ICG) with photodynamic (PDT) treatment ability and the hollow prussian blue nanoparticle Pt-HPB with photothermal treatment ability doped with platinum as photosensitizer, combined with the hydrogel made of oxidized sodium alginate and polylysine, these antibacterial nanoparticles are supported by the hydrogel with good water dispersibility, a kind of composite hydrogel (Pt-HPB-BSA & ICG@Gel) with photothermal photodynamic synergistic antibacterial ability is prepared, as the medical dressing of wound infection antibacterial treatment and promoting wound repair.