314 results about "Indocyanine green" patented technology

A system and method for treating cells of a site in the body, such as at a lens capsule or choroid of an eye. The system and method employs an energy emitting device, and a positioning device, adapted to position the energy emitting device at a position in relation to the cells at the site in the body, such as the cells of the choroid or the lens capsule, so that energy emitted from the energy emitting device heats the cells to a temperature which is above body temperature and below a temperature at which protein denaturation occurs in the cells, to kill the cells or impede multiplication of the cells. The energy emitting device can also include a container containing a heated fluid that can include indocyanine green, which heats the cells to the desired temperature. Alternatively, the energy emitting device can include a laser diode, or a probe that emits radiation, such as infrared or ultraviolet radiation, laser light, microwave energy or ultrasonic energy. The system and method can further employ a material delivery device that can be unitary with or separate from the energy emitting device, an can provide a material, such as indocyanine green, to the cells at the site of interest. A light emitting device can be controlled to direct light onto the site of interest to activate the material present at the cells to alter a physical characteristic of the cells.

The present invention relates to a device for observing a sentinel lymph node (SLN) in a human body. More particularly, the present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and/or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.

A method for treating a lesion of an animal, the animal having at least one vessel that carries blood to the lesion, comprising locating the vessel, administering a composition comprising a photodynamic agent, applying energy to the vessel to photocoagulate the vessel and thereby reduce the rate at which the treatment composition exits said lesion and applying energy to said lesion, of a type and an amount sufficient to excite the photodynamic agent, causing the lesion to undergo photodynamic therapy. Preferably, a dye that is both a fluorescent dye and a radiation absorbing dye, such as indocyanine green dye, is added to the treatment composition to allow (a) confirmation of the presence of the treatment composition in the lesion to be detected by fluorescent angiography and (b) the rate of blow flow to be reduced in the blood vessel feeding the lesion using dye enhanced photocoagulation.

A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.

The preferred indicator is an injection of indocyanine green dye which is detected and quantified by causing it to fluoresce at a sensor location, for example, at the human ear. Quantification is carried out by using cardiac output procedures and where called for, the Valsalva Maneuver is monitored at a monitor/controller giving visual cues to the patient and operator as to the quality of the necessary exhalation pressure maintenance.

The invention provides an indocyanine green composite nanoparticle which comprises indocyanine green, a hydrophobic polymer, polyethylene glycol derived phospholipid and a cancer cell membrane. The indocyanine green is encircled by the hydrophobic polymer and forms a sphere-like structure together with the hydrophobic polymer; the polyethylene glycol derived phospholipid penetrates the cancer cell membrane and forms a vesicle structure together with the cancer cell membrane; the sphere-like structure is wrapped in the vesicle structure. The invention further provides a preparation method and application of the indocyanine green composite nanoparticle. When the indocyanine green composite nanoparticle is applied, the indocyanine green composite nanoparticle has an efficient tumor targeting property, the indocyanine green can hardly gather and high stability is realized.

The invention provides indocyanine green nanometer targeted liposome. The indocyanine green nanometer targeted liposome comprises indocyanine green, a phospholipid layer and a folic acid-modified polyethylene glycol derived phospholipid layer, wherein the indocyanine green is surrounded by the phospholipid layer; the folic acid-modified polyethylene glycol derived phospholipid layer comprises polyethylene glycol derived phospholipid and folic acid connected with the polyethylene glycol derived phospholipid through an amido bond; phospholipid in the polyethylene glycol derived phospholipid is inserted in the phospholipid layer; the folic acid is exposed outside the phospholipid layer; the mass ratio of the indocyanine green to the phospholipid to the folic acid-modified polyethylene glycol derived phospholipid is (1-5): (1-3): (1-3). The invention further provides a preparation method of the indocyanine green nanometer targeted liposome and photo-thermal treating application thereof; when the indocyanine green nanometer targeted liposome is applied, the indocyanine green is difficultly gathered, and has excellent stability and a targeting property.

The invention relates to a fluorescence nanometer probe, comprising an inner core formed by polyglycolide lactide, a middle layer formed by phospholipid surrounding on the surface of the inner core and a shell formed by distearoyl phosphatidyl ethanolamine-polyethylene glycol which contains amino or carboxyl and partially penetrates through the middle layer, wherein indocyanine green is dispersed in the inner core. According to the invention, a core-shell structure is formed to ensure that the indocyanine green is wrapped in the polyglycolide lactide, therefore, the indocyanine green is effectively avoided from being aggregated and decomposed and the stability is increased; and the wrapped indocyanine green has a near-infrared fluorescence characteristic to ensure that the background fluorescence penetrating tissues is small and then can be relatively accurately applied to bioluminescence labeling.

The invention provides an Au-ICG (gold-indocyanine green) lipidosome multifunctional nano probe and application thereof. The nano probe consists of a kernel and a shell, wherein the kernel is a nanogold particle of which the surface is wrapped with a poly-dopamine layer and adsorbs indocyanine green; the shell is a DSPE-PEG (distearoyl phosphatidyl ethanolamine-polyethylene glycol) lipidosome film which is coupled with lactobionic acid and is chelated with Gd<3+> ions. The Au-ICG lipidosome multifunctional nano probe disclosed by the invention can be used for various image modes such as MRI (nuclear magnetism imaging), CT (computed tomography) imaging and near infrared fluorescence imaging of the liver cancer; a patient only needs to stand medicine supplying of a contrast agent, and various diagnosis effects can be achieved; furthermore, by virtue of the improvement of the sensitivity, the using amount of the contrast agent can be reduced, so that the toxic and side effect is further relieved; under near infrared illumination at 808 nm, adsorbed ICG molecules can effectively convert light energy into heat energy to produce superhigh heat of 60-70 DEG C, so that liver cancer cells can be killed thermally; therefore, the multifunctional nano probe can be used as a multimodal contrast agent for liver cancer diagnosis and can be used as a photothermal therapy agent for the liver cancer.

The invention relates to methods of identifying, detecting, and locating a tissue(s), nodule(s) or mass(es) and its draining lymph nodes that is/are suspected to be abnormal, typically a neoplasm (i.e., cancer, malignancy, premalignancy) in an individual undergoing an invasive procedure (i.e., surgery or endoscopy) or a non-invasive procedure (ie. radiology). The method involves the use of, for example, indocyanine green (ICG). The uptake of this dye is different by diseased tissues and lymph nodes compared to non-diseased tissues when administered at the appropriate combination of dose and time and monitored with an appropriate device that can excite and capture the signal.

A system, method and apparatus are disclosed for using a transcutaneous detection system to measure the quantity of a circulating organ activity detection analyte in the blood, and thereby assay the activity of an organ. A preferred organ for assay is the human liver and a preferred indicator is indocyanine green (ICG) dye The procedure is under the control of a monitor/controller having a visual display and capable of providing cues to the operator. A sensor array apparatus for use in conjunction with the system monitor/controller is configured for increased sensitivity of assaying organ function.

The invention relates to a preparation method and application of an indocyanine green loaded self-assembled multifunctional nano targeting system. The indocyanine green loaded self-assembled multifunctional nano targeting system can be used for effectively solving the problems of the existing antitumor drugs in tumor therapy that the targeting property is poor, the toxic or side effects are high, the half decay time is short, the dosage of administration is high, the function is single, and the like. Doxorubicin is connected with hydroxychloroquine in a manner of using disulfide bonds as connecting arms so as to form self-assembled nanoparticles, then, indocyanine green is physically adsorbed into the nanoparticles, and then, the nanoparticles are wrapped by phospholipid polyethylene glycol folic acid so as to form the indocyanine green loaded self-assembled multifunctional nano targeting system, wherein each disulfide bond is 3,3'-dithiodipropionic acid or 2,2'-dithio diacetic acid, and the molecular weight of phospholipid polyethylene glycol folic acid is 1-4kDa. The indocyanine green loaded self-assembled multifunctional nano targeting system is simple and convenient in synthesis process, has the advantages of good biocompatibility, high targeting property, reduction sensitivity, hypotoxicity and the like and is an innovation of pharmaceutical preparations for the diagnosis and treatment of tumors.

The invention relates to the field of biologic medicines, and discloses an albumin indocyanine green paclitaxel compound as well as a preparation method and an application thereof. The albumin indocyanine green paclitaxel compound consists of indocyanine green, paclitaxel and human serum albumin, wherein the indocyanine green and the paclitaxel are absorbed onto human serum albumin through a hydrophobic force. The compound is good in water solubility, biocompatibility and dispersity, can generate heat in laser radiation, can promote more material cells, can kill tumor cells, is further high in fluorescence property, and can instruct joint treatment of photo-thermal therapy and chemotherapy in a fluorescence imaging mode. The preparation of the albumin indocyanine green paclitaxel compound is simple to operate and can be applied to on-scale preparation of the albumin indocyanine green paclitaxel compound, and the raw materials are easily available.

Provided is the following indocyanine green (ICG)-containing particle to be used as, for example, a contrast agent for fluorescent imaging or photoacoustic imaging. The leakage of ICG from the particle in a serum is prevented and hence the particle can stably retain ICG. According to a particle characterized by having an aggregate of indocyanine green and a phospholipid, the leakage of ICG from the particle in a serum or the like is prevented and hence ICG can be stably retained in the particle.

The invention provides thermo-sensitive liposome. The thermo-sensitive liposome comprises a chemotherapeutic drug, a photosensitizer, phosphatidylcholine and polyethylene glycol-derived phospholipid, wherein the photosensitizer is indocyanine green or chlorins e6; the grain size of the thermo-sensitive liposome is 40-60 nm; by virtue of living-body fluorescence imaging, a distribution process of the thermo-sensitive liposome can be observed in real time; under a near-infrared light irradiation condition, the chemotherapeutic drug can be quickly and effectively released, so that the chemotherapeutic drug can be enriched at a target part very well; the obtained thermo-sensitive liposome particle has smaller particle diameter less than 100 nm, and good biocompatibility. The preparation method of the thermo-sensitive liposome is simple and easy to operate.

The invention provides a cationic polymer-loaded paclitaxel/indocyanine green (ICG) co-delivery micelle and a preparation method thereof. To simultaneously load the chemotherapeutic paclitaxel and the photosensitizer ICG, an amphiphilic degradable cationic nano-micelle MPEG-PCL-PEI is used as a loading medium for the chemotherapeutic paclitaxel; a cationic polymer block is introduced into a polymer MPEG-PCL which forms the nano-micelle, so surface charges of the micelle can be changed; negatively-charged ICG molecules are adsorbed through interaction between positive and negative charges, and sustained release of paclitaxel and ICG is realized; so a novel method is provided for integrated diagnosis and treatment of tumors. According to the invention, the triblock cationic polymer synthesized from an amphiphilic polymer-grafted cationic fragment can simultaneously load the chemotherapeutic paclitaxel and the photosensitizer ICG approved by FDA, so compounding of the chemotherapeutic and fluorescence molecules is realized, and fluorescent imaging of a tumor site as well as target drug delivery for a tumor is complished.

The invention discloses a near-infrared light response nanoparticle which comprises a nano-carrier, a nano-carrier entrapped substance, a photosensitizer and a near-infrared light response phase change material for packaging, wherein the nano-carrier entrapped substance comprises an H2S donor and an anticancer drug. Hydrophobic DATS, hydrophilic indocyanine green and epigallocatechin gallate are encapsulated into mesoporous polydopamine nanoparticles by utilizing the amphiphilic property of myristyl alcohol, and finally, the MPDA-ICG/DATS/EGCG@TD nanoparticles are obtained. After the nano system is irradiated by near-infrared laser, ICG in the nano system can effectively convert NIR into heat; and the phase change material TD responds to temperature rise and is changed into liquid from solid, so that rapid release of DATS and EGCG is promoted.

The invention discloses a fundus disease laser photo-thermal treatment system based on gold nanorods. The fundus disease laser photo-thermal treatment system based on the gold nanorods comprises the gold nanorods, a treatment laser source, a fundus imaging system and a personal computer (PC) control platform. The gold nanorods are combined by a gold seed method, and grows according to surface active agent hexadecyl trimethyl ammonium bromide micelle shaped template in an orientated mode, silver ion concentration in solution is changed to control draw ratio of the gold nanorods, and after modification of polyamide-amine type arborization high polymer, vessel contrast agent indocyanine green is connected with pathology novel vascular endothelial cell peculiar arginine-glycine-aspartic acid polupeptide in a covalent mode to assist working.

The invention discloses a door control type medicine composition integrating cancer imaging and phototherapy and a preparation method. The preparation method comprises the following steps: (1) preparing CuS@mSiO2 nano particles in a core-shell structure; (2) preparing ammoniated CuS@mSiO2 nano particles; and (3) preparing CuS@mSiO2-TD/ICG. Each CuS@mSiO2 nano particle in the core-shell structure, prepared in the invention, is provided with a silicon dioxide shell with a suitable thickness, so that the common load of indocyanine green and TD can be guaranteed; the CuS@mSiO2-TD/ICG can well play a preferable door control role, and the release of indocyanine green is controlled; and during systemic circulation, the effect of opto-thermodynamics and photodynamics combination therapy is achieved. The door control type medicine composition has good water solubility and biocompatibility. The therapeutic effect of tumors can be effectively strengthened, and the toxic and side effects are reduced. The preparation technology is simple, the method is stable and reliable, the reaction controllability is high, and the used raw materials are easily obtained and are low in cost.

A membrane visualization instrument may include a flow control mechanism having a flow control mechanism distal end and a flow control mechanism proximal end, a visualization fluid chamber of the flow control mechanism, a visualization fluid guide having a visualization fluid guide distal end and a visualization fluid guide proximal end, and a hypodermic tube having a hypodermic tube distal end and a hypodermic tube proximal end. The visualization fluid guide proximal end may be disposed within the flow control mechanism. The hypodermic tube proximal end may be disposed within the visualization fluid guide. A visualization fluid, e.g., indocyanine green dye, kenalog, trypan blue dye, etc., may be disposed within the visualization fluid chamber. A compression of the flow control mechanism may be configured to irrigate the visualization fluid out of the hypodermic tube proximal end.

A three-dimensional imaging of skin angiopathy and intelligent treatment system, belonging to technology field of medical equipment, comprising: optical fiber used to inject laser into skin tissue, optical fiber used to convey laser reflected or refracted by skin to optical flame detector, near infrared ray optical flame detector / charge-coupled device, Doppler / coherent signal processing system, computer real-time detection and control system working station, laser parameter controller and laser device. The laser device is infrared laser of 805 nm. The invention employs the selective absorption of infrared laser by indocyanine green, which biological tissue adsorbs little and realizes the selective damage to blood vessel. The wavelength of laser of 805-810 nm is much longer than that of currently use, which is 595 nm, so the penetration is deeper which treats deeper blood vessel better, choosing optimum laser parameter automatically by intelligent blood vessel skin damage treating probe, which avoids artificial error, improves treatment effect, reduce purpura and times of repeat treatment.