673results about How to "High inhibition rate" patented technology

The invention discloses an antibiotic Bacillus amyloliquefaciens with powerful bacteriostasis and wide bactericidal spectrum. The strain has been preserved in the China General Microbiological Culture Collection Center and the taxonomy name of the strain is: Bacillus amyloliquefaciens with preservation number CGMCCNo.4777. The antibiotic Bacillus amyloliquefaciens has powerful bacteriostasis, wide bactericidal spectrum, high inhibition rate up to above 93.5% on the rice blast fungus, the Botrytis cinerea and the Phytophthora parasitica; the Bacillus amyloliquefaciens also has very strong stress resistance, and very strong resistance to the acid and alkali, and is suitable to be used as microbial bactericide.

The invention discloses a muting sensitive lactalbumin hydrolysate and a preparation method thereof. The method mainly comprises the following steps: dissolving condensed whey protein in the water, then carrying out denaturation under high temperature, carrying out hydrolysis by using the protamex composed of alkali protease, papain and flavourzyme, treating the lactalbumin hydrating solution with desalinization and drying to obtain the lactalbumin hydrolysate of the invention. The lactalbumin hydrolysate of the invention has high suppression ratio of Beta-lactoglobulin and Alpha- lactalbumin, can reduce or eliminate cow milk allergic reaction; furthermore, the lactalbumin hydrolysate can also produce other active materials, thus also having the functions of promoting immunity, being easy to digest and absorb and reducing blood pressure; and the lactalbumin hydrolysate has high security and no side effect, bitter taste or other bad flavors.

The invention relates to a ferulic acid shown in a general formula (I) and the application of derivatives thereof to pesticides. When used as novel anti-phytoviral agents, the derivatives can well inhibit tobacco mosaic viruses, pepper viruses, tomato viruses, sweet potato viruses, potato viruses, melon viruses, maize dwarf mosaic viruses and the like, and effectively prevent and control the virus diseases of various crops such as tobacco, peppers, tomatoes, melons, grains, vegetables, beans and the like, and are particularly suitable for preventing and controlling tobacco mosaic. Meanings of each group are shown in specifications.

The invention discloses a preparation method and application of cycloastragenol. The preparation method of the cycloastragenol comprises the following steps: by using astragaloside or astrasieversianin as a raw material, oxidizing, reducing, hydrolyzing, extracting and purifying to obtain high-purity cycloastragenol. The method is simple to operate, gentle in condition, good in product quality and high in yield. The cycloastragenol can be applied to preparation of anticancer adjuvant therapeutic medicine. An anticancer adjuvane therapeutic medicine prepared by using the cycloastragenol as a pharmaceutical active ingredient has the anticancer adjuvant therapeutic effect of enhancing the anticancer therapeutic effect, reducing the toxicity of the anticancer medicine, preventing and treating the neutropenia caused by the anticancer medicine therapy.

The invention relates to an anti-allergic composition for relieving as well as an application thereof. The anti-allergic composition for relieving comprises the following components: a first anti-allergic composition, a second anti-allergic composition, an anti-allergic peptide composition, Crambe abyssinica seed oil, bisabolol, and a Cardiospermum halicacabum extract product; the active componentof the first anti-allergic composition comprises 4-tert-butylcyclohexanol and 2-(3-(4-hydroxyphenyl)propanamido)benzoic acid; the active components of the second anti-allergic composition comprise anextract product of Stephania tetrandra, potassium lactate, phenoxyethanol, and dipotassium glycyrrhizinate; the active components of the anti-allergic composition comprise palmitoyl tripeptide-8 andacetyl tetrapeptide-15. The anti-allergic composition for relieving is evaluated by a macrophage nitric oxide inflammation releasing model, inhibition rate of nitric oxide releasing reaches 46.07%, and inhibition rate of histamine reaches 61.59%.

The invention discloses a terminal amidocyanogen star-shaped lactic and glycolic acid/polyethyleneglycol segmented copolymer, a preparation method, drug-loaded nano-micelle and application thereof. The preparation method of the terminal amidocyanogen star-shaped lactic and glycolic acid/polyethyleneglycol segmented copolymer: (1) glycolide, polyhydroxy activator, stannous octoate and lactide are added into a polymerized tube sealing for vacuumized nitrogen permutation and reaction, and terminal hydroxyl star-shaped lactic and glycolic acid can be obtained; (2) butanedioic anhydride is added for reaction to prepare terminal carboxyl group star-shapedl actic and glycolic acid; (3) the terminal carboxyl group star-shaped lactic and glycolic acid is dissolved in anhydrous toluene, then doublepointed amidocyanogen polyethyleneglycol, N and N'- dicyclohexylcarbodiimide are added for reaction, solvent is evaporated to dryness and aether is added for sedimentation to prepare the terminal amidocyanogen star-shaped lactic and glycolic acid/polyethyleneglycol segmented copolymer which can form about 100nm of micelle automatically in water solution. Hydrophobic nature drugs can be loaded in the caryon of the micelle and putamen surface of the micelle is rich of high activity and freedom terminal amidocyanogen arms that can couple with various bioactivators to achieve the effect of targeted release.

A slowly-releasing nano-particle of curcumin is prepared from the nano-particle of curcumin and the degradable polymer chosen from polylactic acid and the polylactic acid-hydroxyacetic acid copolymer by emulsion-solvent diffusion technique. It has high water dispersity and long releasing time (more than 2 weeks).

The invention relates to a surface material with protein adsorption resistant property and a preparation method thereof, belonging to the technical field of biological materials. The surface material is an organic silicon surface material polymerized by monomer molecules with diionic property and organic silicon, has good protein adsorption resistant property and can be extensively applied to the fields of marine antifouling materials and biomedical materials. The surface material which has the protein adsorption resistant property through surface modification is prepared by carrying out graft polymerization on the monomer molecules with the diionic property on the surface of an organic silicon substrate; the surface material is combined with water molecules in a marine environment to form a water film on the surface of the material and can prevent the adsorption of proteins on the surface of the material because the water molecules contained in the water film are compactly arranged, thereby inhibiting the further adhesion of marine fouling organisms on the surface of the material and achieving the effect of effectively preventing and removing the fouling of marine organisms; in addition, the invention has wide application prospect.

The invention prepares composite water evaporation inhibitor through adopting the built technology. The technical characteristics are that long-chain fatty alcohol and short-chain alcohol are remixed into molecular film base material, stable solution is prepared through dissolving appropriate spreading solvent which is chosen in ambient temperature, thereby obtaining the water evaporation inhibitor. The water evaporation inhibitor which is obtained through the process can automatically spread out on the water level to form an insoluble molecular film, which has favorable temperature interference resistance ability, matter interference resistance and self-restoring ability, and the efficiency of inhibiting water evaporation is reduced as time prolongs, thereby having excellent stability. The preparation process of the invention is simple, and can be prepared in-situ. The water evaporation inhibitor which is prepared has extensive application prospect in water resource protection field, has great significance for solving the problem of water scarcity in arid area and reducing water resource loss, and can bring out enormous economic benefits and social benefits.

The invention discloses a ruthenium-anthraquinone conjugate, the preparation process thereof and the application as a photo-dynamic therapy photosensitizer. The general formula of the ruthenium-anthraquinone conjugate of the invention is [Ru(L)2HAIP].(PF6)2, the general formula of the HAIP is 1,8- dihydroxy -9,10- anthraquinoneimidazole [4,5-f][1,10] phenanthroline, the general of the L is bpy or phen. The preparation process for the ruthenium-anthraquinone conjugate comprises the following procedures: 1. the synthesis of the HAIP: 1,8- dihydroxy -9,10- anthraquinone-3-aldehyde is reacted with the phenanthroline5,6-diketone to produce the HAIP; 2. Ru(L)2Cl2 is reacted with HAIP and NH4PF6 to produce the [Ru(L)2HAIP].(PF6)2. The invention takes the aloe-emodin as the raw material and the ruthenium polypyridyl complex has single chemical composition; the synthesis route is simple and the yields are higher; during the experiment, the compound shows the light suppression to the growth of cancer cells.

The invention discloses a method for detecting whitening efficacy of melothria heterophylla root extracts and relates to natural melothria heterophylla root extracts. The method comprises the following steps: (1) preparing a tyrosinase solution, an L-tyrosine solution and a PBS (phosphate buffer saline) solution as base solutions, then preparing four to-be-detected solutions, namely an arbutin solution, a supercritical CO2 extracted melothria heterophylla root extract solution, a water extracted melothria heterophylla root extract solution and an alcohol extracted melothria heterophylla root extract solution, quantitatively adding each base solution and one of the four to-be-detected solutions in four test tubes and shaking the solutions to be uniform; (2) heating the four test tubes in a water bath kettle, respectively determining the absorbance of each solution in each test tube under a wave length of 475nm and calculating the inhibition ratio of the to-be-detected solution with the concentration to tyrosinase; and (3) repeating the steps (1) and (2), determining the inhibition ratio of the other to-be-detected solutions to tyrosinase, determining the inhibition ratio of the other to-be-detected solutions with different concentrations to tyrosinase, and then according to the comparison of determination results, obtaining the whitening efficacy of each melothria heterophylla root extract and arbutin under the same concentration as well as the whitening efficacy of each melothria heterophylla root extract or arbutin under different concentrations.

The invention discloses a bio-organic fertilizer for preventing and treating soil-borne diseases. The bio-organic fertilizer is prepared from the following raw materials: a microbial inoculum, peanutoil pressing residues, corn starch, filter mud, beef extract, soybean cake, monopotassium phosphate, urea, molasses, potassium sulfate, water and the like. The microbial inoculum is composed of Bacillus polymyxa and further comprises any one or a mixture of more than one of Bacillus amyloliquefaciens, Bacillus mucilaginosus and Bacillus pumilus. The invention also provides a preparation method andan application method of the bio-organic fertilizer. The bio-organic fertilizer disclosed by the invention is also rich in organic carbon and organic nitrogen, so that the colonization and function exerting capabilities of functional microorganisms in soil are improved, the growth of pathogenic microorganisms is favorably inhibited, and soil-borne diseases such as root rot, bacterial wilt, seedling blight, damping-off, canker and root-knot nematode disease are effectively prevented. The use amount of chemical fertilizers and pesticides can be reduced, guiding significance is provided for production of harmless agricultural products, and good social benefits and economic benefits are achieved.

The invention belongs to the technical field of composite reverse osmosis membranes and particularly relates to a preparation method of a modified pollution-resistant hybridized reverse osmosis membrane. According to the preparation method, by introducing a combined inorganic nano-particle of a graphene oxide nano-particle, nano-Ag and nano-SiO2 an dissolving the combined inorganic nano-particle by virtue of a compound organic solvent, the result shows that an inorganic nano-material has relatively good dispersity in a polymer film matrix and further has relatively good consistency between twophases of the inorganic nano-particle and a polymer. A polyamide functional layer is hybridized and is grafted with hydrophilous an NH2-PEG-OH molecular chain through chemical reaction, so that the hydrophily of a membrane is improved, and the prepared composite membrane has relatively excellent antibacterial property, pollution resistance and thermal stability and further has huge prospects in industrial water treatment.

Cepharanthine is used as effective component in preparing medicine for resisting SARS virus. Within the safe dosage range, the present invention has high inhibition rate to SARS virus and powerful effect of preventing SARS virus infection. The medicine can alleviate the syndromes of SARS patient and has fast after cure, less toxicity, high stability and other advantages.

The invention relates to microbiology and biotechnology, and particularly discloses spore-producing bacillus amyloliquefaciens for inhibiting plant pathogenic fungi and an application of spore-producing bacillus amyloliquefaciens in prevention and treatment of gray mold. The Bacillus amyloliquefaciens 1841 is preserved in the China General Microbiological Culture Collection Center with preservation number of CGMCC No. 15465 on March 20, 2018. The strain is introduced from Russia and has broad antibacterial spectrum and high inhibition rate. Fermentation liquor and bacteriostatic substances ofthe strain and a preparation prepared from the fermentation liquor are used for preventing and treating gray mold caused by botrytis cinerea and other fungal diseases, and the bacillus amyloliquefaciens has good effect, can be industrially produced, and is simple to use, non-toxic, pollution-free, green, environmentally friendly and the like, and a preparation process is simple.

The present invention discloses a method for the preparation of a protein peptide, peptide powder prepared thereby, and use of the peptide powder in hypouricemic food products or health care products. The peptide powder is capable of inhibiting the activity of xanthine oxidase and effectively reducing uric acid. The method in an example of the present invention comprises: mincing the tuna, heating with steam or water to obtain a pretreated tuna, enzymolysing the pretreated tuna, deactivating the enzyme, centrifuging, removing impurities to obtain a supernatant, concentrating, and drying to obtain the peptide powder of interest.

The invention relates to wide-spectrum bacillus subtilis BSXE-1601 for inhibiting aquatic product pathogenic vibrio, and further relates to a compound bacterial preparation taking the bacillus subtilis as the main ingredient. Meanwhile, the invention also relates to a preparation method of the compound bacterial preparation by taking the bacillus subtilis as the main ingredient. The bacillus subtilis BSXE-1601 is preserved in China General Microbiological Culture Collection Center (CGMCC), the culture preservation number is CGMCC NO. 15949, and the preservation data is June 19th, 2018. The bacillus subtilis can effectively inhibit growth of various kinds of vibrios such as vibrio parahaemolyticus, vibrio alginolyticus, vibrio vulnificus and vibrio harveyi, meanwhile can promote growth of farmed animals to some extent, and improves the survival rate and bait utilization rate.

The invention discloses application of flavone type allelochemicals in spartina alterniflora to algae growth inhibition. The application comprises the steps that the flavone type allelochemicals in spartina alterniflora are added into an algae containing water body, so that the concentration of the flavone type allelochemicals in the water body is greater than 0.1g/L. The flavone type allelochemicals capable of inhibiting the algae growth are extracted from the spartina alterniflora; the outbreak of harmful algae can be treated and controlled; the resource utilization of the spartina alterniflora can also be realized.

The invention relates to multipiptide protein active substance in a kind of bloody clam (Arca subcrenata Lischke; Scapharca subcrenata), the prepn. method and the uses. The prepn. method is that bloody clam is homogenated to obtain superantant which is treated by chromatography in ion exchange column, desalt, chromatograph separation in gel colum to be combined to several peaks with molecular weight 3-15 KDa which is concentrated and dried to obtain multipeptide protein active substance. Said active substance has 73.72 percent of cancer-inhibiting ratio and can be made as anti-cancer medicine.

The invention provides a PTX derivative which can inhibit the multidrug resistances of tumor cells, its preparation method, and its use in the inhibition of the multidrug resistances of the tumor cells. The molecular formula of the PTX derivative is Pluronic-(S-S-PTX)2, wherein Pluronic represents a surfactant Pluronic having a structural general formula being (HO-[CH2CH2O]X-[CH2CH(CH3)O]Y-[CH2CH2O]X-H, x and y are numbers of groups, x is an integer between 2 and 100, and y is an integer between 30 and 70; PTX is an antitumor drug paclitaxel; S-S- is a disulfide bond; and two PTX molecules are connected with one Pluronic molecule through the disulfide bond.

The invention relates to an azoxystrobin nanocapsule with a shell-core structure and a preparation method thereof. The azoxystrobin nanocapsule is prepared from a pesticide active ingredient, namely, azoxystrobin and a chitosan-polylactic acid graft copolymer as a packaging material; the weight ratio of azoxystrobin to chitosan-polylactic acid graft copolymer is (20:1) to (1:2); azoxystrobin is enveloped by a carrier to form the capsule with the shell-core structure; the particle size of the capsule is 280nm to 4.5 microns; the encapsulation efficiency of the capsule on the pesticide active ingredient azoxystrobin is over 70%, the drug-loading capacity is over 10%, the accumulated release rate within 400 hours can be up to over 80%, a plurality of fungal diseases on vegetables, fruit trees and grapes can be effectively prevented and controlled, and azoxystrobin nanocapsule has an important application value.