6results about How to "Strong antagonistic effect" patented technology

This invention proposes a new class of compounds that effectively antagonize integrin α4β7, which are compounds represented by formula (Y), or stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs of compounds represented by formula (Y):

This invention provides a strain of *Pseudomonas aeruginosa* RL76, its bacterial suspension, its preparation method, and its applications, belonging to the field of agricultural microbiology technology. The *Pseudomonas aeruginosa* RL76 was deposited at the China General Microbiological Culture Collection Center (CGMCC) on January 26, 2026, with accession number CGMCC No. 37531. This invention utilizes a mixture of filter mud and soil for sugar beet cultivation. It was found that, under the same pathogen inoculation conditions, the filter mud treatment significantly alleviated the occurrence of damping-off disease in sugar beets compared to the non-filter mud treatment, suggesting that the filter mud plays a role in increasing the relative abundance of beneficial microorganisms in the soil. Therefore, this invention isolated a strain of *Pseudomonas aeruginosa* RL76 with highly efficient antagonistic activity against *Rhizoctonia solani* from the rhizosphere soil of sugar beets cultivated using a mixture of filter mud and soil, and for the first time discovered its effective control of sugar beet damping-off disease while also promoting sugar beet growth, representing a groundbreaking achievement.

Yohimbine derivatives, their preparation methods, and uses. This invention discloses compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I. The compounds of Formula I of this invention, as adrenaline receptor α2A (ADRA2A) antagonists or partial antagonists, can treat and / or prevent inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), Crohn's disease (CD), or enteritis.

The bacillus subtilis strain against aeromonas and its application, the bacillus subtilis strain of the present application is named bacillus subtilis (wgb0621), and the preservation number is CCTCC NO: M 2026135. Bacillus subtilis The bacillus subtilis strain has good contact inhibition activity on aeromonas veronii and aeromonas hydrophila, can improve the survival rate of grass carp after being infected with aeromonas, has good safety, and is not dependent on diffusible bacteriostatic substances. The bacillus subtilis strain is suitable for biological prevention and control of aeromonas disease in aquaculture, and has good application prospect.

This invention relates to a strain of *Bacillus belye* H501 and its application in promoting the growth of kelp seedlings, belonging to the field of microbiology. The strain was deposited on December 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC NO. 37160. The strain can grow normally within a salinity range of 15-25℃ and 1-7%, highly matching the kelp seedling cultivation environment, and does not produce alginate lyase, thus not disrupting the natural defense barrier of kelp. Applying this strain to kelp seedling cultivation can shorten the seedling cycle by approximately 3-5 days, effectively reducing energy consumption and labor costs. Furthermore, H501 exhibits significant antagonistic activity against the common aquatic pathogen *Aeromonas hydrophila*, demonstrating potential for biocontrol applications.