15results about How to "Strong antagonistic effect" patented technology

The application discloses a bacillus urosemiae and a bacteriostatic preparation based on the bacillus urosemiae and application thereof, and belongs to the technical field of microbial application. Paenibacillus urinalis The bacillus urosemiae is in Latin and is preserved in the China Center for Type Culture Collection, Wuhan University, Wuhan, China, has a preservation number of CCTCC NO: M 20242902, and was preserved on December 25, 2024, and is named Y6N9. The bacillus urosemiae can be applied to preparation of a preparation for antagonizing pathogenic bacteria in aquaculture, and has important application value in disease prevention and control of Pelteobagrus fulvidraco.

This invention proposes a new class of compounds that effectively antagonize integrin α4β7, which are compounds represented by formula (Y), or stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs of compounds represented by formula (Y):

This invention provides a strain of *Pseudomonas aeruginosa* RL76, its bacterial suspension, its preparation method, and its applications, belonging to the field of agricultural microbiology technology. The *Pseudomonas aeruginosa* RL76 was deposited at the China General Microbiological Culture Collection Center (CGMCC) on January 26, 2026, with accession number CGMCC No. 37531. This invention utilizes a mixture of filter mud and soil for sugar beet cultivation. It was found that, under the same pathogen inoculation conditions, the filter mud treatment significantly alleviated the occurrence of damping-off disease in sugar beets compared to the non-filter mud treatment, suggesting that the filter mud plays a role in increasing the relative abundance of beneficial microorganisms in the soil. Therefore, this invention isolated a strain of *Pseudomonas aeruginosa* RL76 with highly efficient antagonistic activity against *Rhizoctonia solani* from the rhizosphere soil of sugar beets cultivated using a mixture of filter mud and soil, and for the first time discovered its effective control of sugar beet damping-off disease while also promoting sugar beet growth, representing a groundbreaking achievement.

The invention belongs to the technical field of agricultural microorganisms, and relates to a Trichoderma koningii strain, a strain fermentation broth thereof and an application of the Trichoderma koningii strain in prevention and treatment of pomegranate fusarium wilt. The invention provides a Trichoderma koningii strain, which is classified and named as Trichoderma koningii, is preserved in Guangdong Microbial Culture Collection Center, and has a preservation number of GDMCC NO: 67115. The trichoderma koningii and the strain fermentation liquor thereof provided by the invention have good bacteriostatic ability, can significantly inhibit growth of sweet potato coracocystis spp. Causing pomegranate fusarium wilt, have the inhibition rate of 88.3%, have the advantages of strong bacteriostatic ability, good control effect and high biological safety, and can be widely applied to prevention and treatment of pomegranate fusarium wilt. The bacillus subtilis has a wide application prospect in the aspect of preventing and treating plant diseases caused by the sweet potato coracocystis longirostris.

The invention relates to the technical field of biocontrol bacteria, in particular to application of Gliocladium mucilaginosum RS44 and a composite flora of the Gliocladium mucilaginosum RS44 and Rahnella RS86 in prevention and treatment of corn root rot. The Gliocladium mucilaginosum RS44 provided by the invention is separated from corn roots which are not subjected to root rot in white cities of Jilin Province, has the characteristics of siderophore production and nitrogen fixation, has a better antagonistic effect on pathogenic bacteria fusarium graminearum, has an inhibition rate of 26.39%, has a good prevention and treatment effect on corn root rot, and can promote corn growth. Besides, the composite flora composed of gliocladium mucilaginosum and rahnella RS86 provided by the invention can effectively inhibit the growth of fusarium graminearum, has a good control effect on the corn root rot, reduces the disease index by 26.32%, and can promote the growth of corn.

The invention belongs to the technical field of biology, and particularly relates to a bacillus amyloliquefaciens strain sf28 and application thereof. The bacillus amyloliquefaciens strain sf28 is separated from rhizosphere soil of a peanut southern blight diseased plant, and the bacillus amyloliquefaciens strain sf28 has the effects of resisting fungi and bacteria and can effectively prevent and treat various plant diseases; comprise peanut bacterial wilt, peanut southern blight, peanut fruit rot, peanut root rot, peanut crown rot, ligustrum lucidum canker and tobacco root rot, and the potting test control effect on the peanut southern blight and the peanut bacterial wilt is remarkable.

This application relates to the field of microbial technology, disclosing a Pseudomonas palleroniana bacterium and its applications, including strain AQY14, whose taxonomic name is Pseudomonas palleroniana, strain number 16S rRNA, and which was deposited at the Guangdong Provincial Microbial Culture Collection Center on January 23, 2026, with accession number GDMCC No:67636. Furthermore, this invention also provides a bacterial agent containing live bacteria of the aforementioned strain AQY14 and its culture. The bacterial culture includes fermentation broth, fermentation filtrate, bacterial suspension, and purified bacterial solution obtained by culturing strain AQY14 in a culture medium. The bacterial agent is a liquid preparation. The culture medium includes Ashby medium, R2A medium, and PDA medium. The provided strain AQY14 possesses multiple growth-promoting and biocontrol functions, exhibiting significant synergistic applications. This strain simultaneously possesses multiple plant growth-promoting characteristics such as nitrogen fixation, dissolution of organic and inorganic phosphorus, potassium solubilization, siderophore production, and IAA production.

The invention relates to the technical field of agricultural microorganisms, and discloses a plant rhizosphere bacillus for antagonizing plant pathogen pectobacterium carotovorum and application, the plant rhizosphere bacillus is bacillus velezensis Mp4-Ha31 and is preserved in the China Center for Type Culture Collection on September 30, 2025, and the preservation number is CCTCC NO: M 20252184. The invention further discloses a preparation method of the plant rhizosphere bacillus for antagonizing the plant pathogen pectobacterium carotovorum and application of the plant rhizosphere bacillus for antagonizing the plant pathogen pectobacterium carotovorum. The plant bacillus velezensis Mp4-Ha31 provided by the invention has the advantages that the antagonism capability on the bacterial plant pathogen pectobacterium carotovorum is relatively strong, the biological pesticide is developed by taking the bacillus velezensis Mp4-Ha31 as an object, and the potential application prospect is realized.

The invention belongs to the technical field of agricultural microorganisms, and relates to bacillus amyloliquefaciens and application thereof. The preservation number of the bacillus amyloliquefaciens D4 is GDMCC No: 66921, the preservation time is September 5, 2025, and the preservation address is Institute of Microbiology, Guangdong Academy of Sciences, Floor 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou. The invention provides a novel bacillus amyloliquefaciens, and the strain has a relatively strong antagonistic effect on potato black shank and sweet potato stem rot, and is beneficial to being applied to the aspect of preventing and treating related diseases. The strain D4 is convenient to produce and prepare, low in cost, simple in process and beneficial to large-scale manufacturing and use. The strain D4 as well as a bacterial suspension and a fermentation broth thereof can be used as active ingredients of prevention and treatment medicaments to be applied to actual production on a large scale.

Yohimbine derivatives, their preparation methods, and uses. This invention discloses compounds of Formula I and pharmaceutical compositions comprising compounds of Formula I. The compounds of Formula I of this invention, as adrenaline receptor α2A (ADRA2A) antagonists or partial antagonists, can treat and / or prevent inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), Crohn's disease (CD), or enteritis.

The bacillus subtilis strain against aeromonas and its application, the bacillus subtilis strain of the present application is named bacillus subtilis (wgb0621), and the preservation number is CCTCC NO: M 2026135. Bacillus subtilis The bacillus subtilis strain has good contact inhibition activity on aeromonas veronii and aeromonas hydrophila, can improve the survival rate of grass carp after being infected with aeromonas, has good safety, and is not dependent on diffusible bacteriostatic substances. The bacillus subtilis strain is suitable for biological prevention and control of aeromonas disease in aquaculture, and has good application prospect.

The invention belongs to the technical field of microorganisms, and discloses an NTase protein, a screening method thereof and application of the NTase protein in preparation of an anti-phage signal system antagonist and / or an antibacterial preparation. The NTase protein provided by the invention specifically comprises an amino acid fragment with a sequence as shown in SEQ ID NO: 1 or a variant fragment with at least 70% sequence identity with the sequence as shown in SEQ ID NO: 1, the NTase protein has an excellent antagonistic effect on a CBASS system of prokaryotes, and the infection efficiency of viruses on prokaryotic cells can be improved by inhibiting the CBASS system; therefore, a better antibacterial effect is achieved, and the compound has a very excellent application prospect in research and development of novel antibacterial drugs.

This invention belongs to the field of microbial and biological control technology, specifically relating to a strain of *Bacillus polymyxa* and its application in biocontrol and growth promotion. Specifically, this invention screens and obtains a strain of *Bacillus polymyxa* (… Paenibacillus polymyxa GLZ219, as demonstrated in experiments, exhibits a high inhibition rate against the pathogen causing tomato neck and root rot; simultaneously, this strain also... Rhizoctonia solani It exhibits good antagonistic effects against nine common plant pathogens and can be widely applied to the green control of various crop diseases. Furthermore, *Bacillus polymyxa* GLZ219 possesses nitrogen-fixing and potassium-solubilizing abilities, and can secrete indoleacetic acid and siderophores, effectively promoting tomato plant growth. Tomato seedlings treated with its fermentation broth show a significant increase in plant height. It can control diseases, improve crop growth, and increase crop yield and quality, demonstrating broad application prospects.

The application discloses a Pseudomonas aeruginosa, which is Pseudomonas aeruginosa EB-Q03-02, and the preservation number is CGMCC No.30779; and the application of the Pseudomonas aeruginosa in preventing and treating Graymold, Pythium aphanidermatum and tobacco blight. The Pseudomonas aeruginosa EB-Q03-02 is separated from the root system of healthy passion fruit, has antagonistic effect on the passion fruit blight, and has obvious antagonistic effect on the passion fruit blight caused by tobacco blight. Further, the Pseudomonas aeruginosa EB-Q03-02 can effectively inhibit the Graymold, Pythium aphanidermatum and tobacco blight, and the inhibition rate is as high as 81% or more.

This invention relates to a strain of *Bacillus belye* H501 and its application in promoting the growth of kelp seedlings, belonging to the field of microbiology. The strain was deposited on December 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC NO. 37160. The strain can grow normally within a salinity range of 15-25℃ and 1-7%, highly matching the kelp seedling cultivation environment, and does not produce alginate lyase, thus not disrupting the natural defense barrier of kelp. Applying this strain to kelp seedling cultivation can shorten the seedling cycle by approximately 3-5 days, effectively reducing energy consumption and labor costs. Furthermore, H501 exhibits significant antagonistic activity against the common aquatic pathogen *Aeromonas hydrophila*, demonstrating potential for biocontrol applications.