47 results about "Ginkgo leaf extract" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a composition for improving obesity and promoting cardiovascular health as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 5 to 20 parts of glycine betaine, 1 to 5.5 parts of choline chloride, 0.5 to 4 parts of L-theanine, 1 to 15 parts of alpha-ketoglutarate calcium, 0.5 to 3 parts of black ginger extract, 0.05 to 0.25 part of black pepper extract, 0.5 to 3 parts of ginkgo leaf extract and 1 to 6 parts of black garlic juice powder. According to the invention, the eight components are selected and are scientifically combined in an optimal quantity ratio range, and the prepared composition can better reduce the inflammation level of a body, regulate abnormal blood fat, improve the lipid metabolism disorder state and effectively reduce impulsive diet behaviors, so that comprehensive improvement of obesity and cardiovascular related risks is realized, and the health-care effect of a human body is improved. The body is effectively assisted to maintain metabolic health.

The invention discloses a tea leaf theanine composition for protecting a central nervous system as well as a preparation method and application thereof, relates to the field of common foods and health-care foods, and aims to solve the problems that most of existing central nervous protection products are single components or are simply compounded, the synergistic effect is weak and the bioavailability is low. The preparation method comprises the following steps: S1, mixing the tea leaf theanine, the emblic leafflower fruit powder, the ginkgo leaf extract, the wolfberry fruit powder and other raw materials according to a specific ratio, and performing high-temperature sterilization and cooling to obtain a fermentation substrate; s2, inoculating a composite activation microbial inoculum composed of plant lactobacillus, lactobacillus acidophilus and lactobacillus reuteri, and carrying out constant-temperature anaerobic fermentation; and S3, freezing and centrifuging at 4 DEG C, concentrating with an RO membrane, and freezing and drying to obtain the composition. The viable count of the complex microbial inoculant reaches 2.0 * 10 < 9 >-3.0 * 10 < 9 > CFU / mL, and the strain ratio and the fermentation process are optimized. The composition has a synergistic effect of multiple components, can efficiently protect nervous centralis, and is suitable for preparing related common food, health food or functional food.

The invention relates to the technical field of traditional Chinese medicine health-care products, and particularly discloses an earthworm protein peptide composition for improving vascular embolism and a preparation method thereof.The earthworm protein peptide composition is prepared from, by weight, 28-34 parts of earthworm protein peptide, 20-26 parts of active pharmaceutical ingredients, 1-5 parts of ginkgo biloba extract, 12-15 parts of corn oligopeptide powder and 4-8 parts of auxiliary materials; lumbricus protein peptide, active pharmaceutical ingredients, ginkgo biloba extract and corn oligopeptide powder are used as raw materials, a solubilizing component is added in the preparation process, the solubilizing component is prepared by mixing functional extract, nattokinase and tween-80 according to a certain proportion, the functional extract is prepared by coating grape seed extract with hydroxypropyl-beta-cyclodextrin, and the solubilizing component is prepared by mixing the functional extract, the nattokinase and the tween-80 according to a certain proportion. Through the synergistic effect of the components, the antithrombotic effect of the earthworm protein peptide composition is synergistically enhanced.

The invention provides a fluffy oil-control composition, a preparation method and application of the fluffy oil-control composition in shampoo products, and belongs to the technical field of cosmetics. The fluffy oil control composition is prepared from a plant extract and lauroyl alanine, the plant extract is a mixture of a rice husk extract, a salvia officinalis extract, a ginkgo leaf extract and a rosemary extract, and the antibacterial and oil-control effects of the composition are obviously improved by controlling the mass ratio of the plant extract to the lauroyl alanine and the specific components of the plant extract; when the fluffy oil-control composition is applied to shampoo, the fluffy feeling of hair can be obviously improved.

The invention discloses a soft capsule containing a ginkgo leaf extract and preparation equipment, and relates to the field of ginkgo leaf extraction. The preparation equipment of the soft capsule containing the ginkgo biloba extract comprises an extraction tank and a fermentation tank, and further comprises a spiral groove formed in the fermentation tank; the air bag is connected into the fermentation tank in a sliding manner; the air bag capable of moving up and down and rotating is arranged in the fermentation tank, the stirring rod on the air bag is used for stirring the fermented material, the fermented material is uniformly fermented, suction force can be generated through the grinding shaft rotating along the side wall of the extraction tank, ginkgo leaves floating in water are adsorbed, and the fermentation effect is improved. And then the ginkgo leaves are in contact with the side wall of the extraction tank for extrusion, water is discharged, the ginkgo leaves do not need to be fished out, the ginkgo leaves on the grinding shaft do not need to be cleaned, the working efficiency is improved, and extraction of the ginkgo leaves is facilitated.

The invention relates to a fermented traditional Chinese medicine composition for preventing and treating piglet viral diarrhea as well as a preparation method and application thereof, and relates to the technical field of livestock breeding. The feed is prepared by taking traditional Chinese medicine components as basic raw materials and adding probiotics for fermentation, and the traditional Chinese medicine components comprise the following raw materials in parts by weight: 0.5-1.5 parts of cardamine violifolia dry powder, 5-15 parts of Chinese pulsatilla root, 10-20 parts of coptis chinensis, 10-20 parts of golden cypress, 10-20 parts of ash bark, 4-8 parts of turmeric, 6-10 parts of pumpkin seeds and 4-8 parts of a ginkgo leaf extract feed additive. Through cooperation of multiple components, the immunity and antioxidant functions of the body are enhanced, the structural integrity of the intestinal tract is maintained, piglet diarrhea caused by PEDV infection is effectively relieved, and growth and development of the piglet are promoted; local specialty crops are selected as medicines, and theoretical basis and practical reference are provided for deep processing of local genuine medicinal materials and PED prevention and control.

The invention belongs to the field of animal feed, and particularly relates to a feed composition for improving body functions of camels and nutritional effects of camel milk and application of the feed composition. The feed composition takes first-crop alfalfa hay as a basic raw material, contains corn flour, soybean meal, flax residues, oil sunflower residue powder, rose willow powder, sea-buckthorn powder, elaeagnus angustifolia powder, alhagi sparsifolia powder or peganum harmala powder, soybean grass powder and cistanche deserticola residue powder, and is further matched with a Chinese wolfberry extract and a ginkgo leaf extract to serve as a functional additive. The feed is suitable for the camels in the lactation period, can improve the immunity and oxidation state of the camels, and improves the content of immunoglobulin, amino acid, folic acid, taurine, unsaturated fatty acid and other components in the milk of the camels. The obtained camel milk is suitable for producing dairy products with nutrient enrichment value. The feed is natural in component source and good in palatability, and can be widely applied to the field of camel breeding.

1. The name of this design product: Packaging box (Nianniankang Ginkgo Leaf Essence). 2. Purpose of this design product: Mainly used for the packaging of Nianniankang Ginkgo Leaf Essence. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The design for which protection is sought includes color.

The application discloses a kind of preparation and application of broad-spectrum antibacterial antiviral nanometer zinc and compound nanometer zinc, belongs to the technical field of medical materials.The ginkgo leaf extract is mixed with zinc salt aqueous solution, reduction reaction is carried out under the action of ultrasonic and stirring, and nanometer zinc solution is obtained.Vitamin C and N-acetyl cysteine are added to nanometer zinc solution, reduction reaction is continuously carried out under the action of ultrasonic and stirring, then mixed with equal volume of water solution containing anti-inflammatory antipyretic analgesic component uniformly, and compound nanometer zinc solution is obtained.Nanometer zinc solution or compound nanometer zinc solution obtained is mixed with equal mass of sodium hyaluronate hydrogel uniformly to obtain nanometer zinc gel or compound nanometer zinc gel.The method of the application avoids the toxic side effects caused by using chemical reducing agents such as hydrazine hydrate and sodium borohydride for preparing nanometer zinc.The nanometer zinc and compound nanometer zinc of the application have excellent characteristics of broad-spectrum and high-efficiency antibacterial antiviral, and have good application prospect.

The invention belongs to the technical field of edible mushroom cultivation, and discloses a culture medium for promoting growth of edible mushroom hyphae and a preparation method and application of the culture medium. The culture medium comprises the following raw materials in parts by weight: 50-90 parts of cottonseed hulls, 10-30 parts of bran, 3-15 parts of corn flour, 2-10 parts of ferula asafetida root powder, 1-3 parts of ginkgo biloba extract, 4-8 parts of humic acid, 3-5 parts of perlite, 1-3 parts of sodium alginate, 1-3 parts of lime and 0.5-2 parts of chitosan. The raw materials are reasonable in compatibility, the obtained culture medium can remarkably promote rapid growth of edible mushroom hyphae and enhance stress resistance, the hyphae are dense and high in survival rate, and infectious microbes are avoided. The ferula asafetida root powder and the ginkgo leaf extract have a synergistic effect, so that the absorption and utilization efficiency of the hyphae on nutrient substances is further enhanced, and the ferula asafetida root powder and the ginkgo leaf extract jointly promote rapid growth and branching of the hyphae.

The invention relates to application of ginkgo leaf exosomes in preparation of a medicine for treating hearing loss, and belongs to the field of medical technologies and biomedical materials. According to the application of the ginkgo leaf exosome in preparing the medicine for treating the hearing loss, the ginkgo leaf exosome can scavenge free radicals, so that inner ear hair cell apoptosis is inhibited, the inner ear active oxygen content is reduced, and the effect of treating the hearing loss is achieved. Therefore, the technical problems that in the prior art, the bioavailability of the ginkgo leaf extract is low, and the metabolism rate of active ingredients in the body is high are solved.

The invention provides a preparation method of a composition for relieving tinnitus symptoms, which comprises the following steps: stirring and mixing a ginkgo leaf extract, an organic solvent and soya bean lecithin to obtain a component primary solution; adding gamma-aminobutyric acid and alpha-lipoic acid into the component primary liquid, uniformly mixing, and concentrating and purifying to obtain a phospholipidized complex; uniformly mixing soybean lecithin, sitosterol and an organic solvent, concentrating, adding a buffer solution to prepare a liposome mixed solution, carrying out ultrasonic dispersion, adding the phospholipid complex, stirring to obtain a core-shell structure mixed solution, filtering, and freeze-drying to obtain core-shell structure powder; the composition for relieving the tinnitus symptom is obtained by adding the active components and the auxiliaries into the core-shell structure powder, granulating and filling into capsules, a stable core-shell structure is formed by the prepared phosphatidylated complex and lipidosome, the fat solubility and stability of the composition are improved, and the blood-brain barrier transmittance is also improved.

The invention relates to the technical field of traditional Chinese medicine and health food, in particular to a composition for assisting in improving memory, application and a preparation. The composition for assisting in improving the memory comprises the following components in parts by weight: 2-9 parts of ginseng, 2-9 parts of ligusticum wallichii, 3-10 parts of gastrodia elata and 0.2-0.8 part of a ginkgo leaf extract. The preparation method of the composition comprises the following steps: adding water into gastrodia elata for extraction, filtering to obtain medicine residues and an extracting solution, concentrating the extracting solution, adding ethanol for fractional precipitation, and merging precipitates to obtain gastrodia elata polysaccharide; adding the medicine residue, ginseng and ligusticum wallichii into ethanol, extracting, filtering, concentrating under reduced pressure, and drying to obtain extract powder; and finally, mixing the gastrodia elata polysaccharide, the extract powder and the ginkgo leaf extract. Exploration is carried out on extraction methods of all the components, and efficacy experiments prove that the finally prepared composition has a remarkable memory improving effect.

The application belongs to the technical field of cosmetics, and provides an anti-aging composition, a preparation method thereof and application thereof in the cosmetic field.The anti-aging composition comprises rhodiola extract, radix paeoniae extract, ginkgo leaf extract and glutathione; the various plant extracts and the combination of active peptides and plant extracts have significant synergies, and are widely applied in the preparation of cosmetics with anti-aging effects; the composition can effectively improve skin aging problems from multiple aspects; in addition, the anti-aging composition is natural, mild and safe, the preparation method is simple, and the application is conducive to large-scale production.

1. The name of this design product: Packaging box (Antai Water-soluble Ginkgo Leaf Extract). 2. Purpose of this design product: Mainly used for the packaging of Antai Water-soluble Ginkgo Leaf Essence. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture. 5. The design for which protection is sought includes color.

1. The name of this design product: Packaging box (Nianniankang Ginkgo Leaf Essence). 2. Purpose of this design product: Mainly used for the packaging of Nianniankang Ginkgo Leaf Essence. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention discloses a composition for preventing and treating mastitis and its application, relating to the technical field of traditional Chinese medicine preparation. The composition for preventing and treating mastitis comprises a sunflower extract, a ginkgo leaf extract, and aloe vera gel. The aloe vera gel, sunflower extract, and ginkgo leaf extract are compounded and used to obtain a composition having the effects of clearing heat and detoxifying, antibacterial and anti-inflammatory, reducing swelling and relieving pain, and promoting menstruation and lactation. Furthermore, hydrogen has antioxidant properties, high permeability, and biosafety, and can enhance the effect of the composition on the site of inflammation.

The invention provides application of a feed additive to removal of mycotoxin in feed, and particularly relates to the technical field of feed additives. The feed additive disclosed by the invention consists of the following components in parts by mass: 16-21 parts of lycopene; the traditional Chinese medicine composition is prepared from 7-14 parts of carrot extract, 9-15 parts of fructus lycii extract, 11-15 parts of radix astragali seu hedysari extract, 2-5 parts of radix ginseng extract, 6-13 parts of fructus momordicae extract, 8-17 parts of folium ginkgo extract, 12-19 parts of green tea extract, 11-16 parts of honeysuckle flower extract, 6-12 parts of lucid ganoderma extract, 4-9 parts of grape seed extract, 5-10 parts of mulberry extract and 3-7 parts of rhodiola rosea extract. The feed additive disclosed by the invention can be used for effectively reducing mycotoxin residues in livestock and poultry bodies and also can be used for effectively reducing residues of various mycotoxins in animal products.

The invention provides an aquatic feed containing ginkgo biloba extract and a preparation method thereof, and relates to the technical field of aquatic feeds, and the preparation method comprises the following steps: mixing fish meal, soybean meal, rapeseed meal, corn protein powder, monocalcium phosphate, a compound vitamin premix, a compound mineral premix, a binder, residual wheat flour and conventional auxiliary materials of the feed; according to the aquatic feed containing the ginkgo biloba extract and the preparation method of the aquatic feed, the ginkgo biloba extract in a specific proportion is added into a formula of the aquatic feed, and the processes of premixing, mixing, conditioning, granulating, drying and cooling are combined, so that uniform dispersion and stable preparation of the ginkgo biloba extract in the feed are realized; according to the aquatic feed containing the ginkgo biloba extract, the problems of oxidative stress, inflammatory response and immunosuppression of the pelteobagrus fulvidraco under the ammonia stress condition can be pointedly relieved, and the functional application value of the feed is improved.

The invention discloses a method for simultaneously enriching and preparing ultra-high-purity caffeic acid and narcissoside from ginkgo leaves, which comprises the following steps: quickly extracting crushed ginkgo leaves by using a pure methanol solvent in combination with an ultrasonic wall breaking manner at room temperature. Carrying out vacuum filtration on the extracting solution, carrying out rotary evaporation and concentration until no alcohol smell exists, and treating and removing impurities by using an ultrafiltration membrane to obtain a clear solution; and carrying out vacuum drying on the solution to obtain the solid ginkgo leaf extract. The narcissoside and the caffeic acid are prepared from the extract redissolved by methanol through high performance liquid chromatography column fixed peak collection, and the HPLC (high performance liquid chromatography) purities of the narcissoside and the caffeic acid can reach 30-50%. After the first liquid chromatography conditions are adjusted, the solution rich in narcissoside and caffeic acid is subjected to second high performance liquid chromatography accurate peak determination collection, and the HPLC purity of the obtained narcissoside and caffeic acid can reach 99.50% or above. The method is simple and convenient to operate, short in extraction and enrichment time and high in selectivity and reproducibility, and the prepared product is ultrahigh in purity.

1. The name of this design product: Packaging box (Xingfu Youni Ginkgo Leaf Essence). 2. Purpose of this design product: Mainly used for the packaging of Xingfu Youni Ginkgo Leaf Essence. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application discloses a composition with the effects of balancing cortisol, balancing pressure and soothing and application thereof, and belongs to the technical field of functional skin care products. The composition is prepared by compounding paeonia root extract, gardenia fruit extract, mint extract, albizzia lebbeck seed extract, anemarrhena asphodeloides root extract, ginkgo leaf extract and dipeptide-1 in specific mass fractions. The components in the composition have a synergistic effect, can intervene in the excessive activation of the HPA axis from the upstream, balance the cortisol level from the root cause, relieve chronic stress, can significantly reduce the symptoms of skin sensitivity and the level of inflammatory factors, effectively inhibit the inflammatory response and soothe the skin sensitivity. The application solves the technical defects of the prior art that the existing products only have the effect of surface soothing and cannot block the continuous influence of stress on the skin, and provides a solution that takes both the symptoms and the root cause into consideration for the stress-related skin problems.

The invention relates to the technical field of medicines, in particular to stable and efficient doxycycline hydrochloride soluble powder and a preparation method thereof. The efficient and stable doxycycline hydrochloride soluble powder is prepared from composite cyclodextrin, an enteric polymer, beta-carotene and a ginkgo leaf extract. Through beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin composite inclusion and enteric polymer wrapping technologies, the inclusion rate is increased, protection on phenolic hydroxyl groups / enol hydroxyl groups in doxycycline is enhanced, oxidation and hydrolysis are reduced, targeted release of intestinal tracts is realized, and drug failure caused by gastric acid stimulation is avoided.

The invention belongs to the technical field of health care product formulas, and particularly relates to a buccal tablet formula capable of increasing the content of nicotinamide mononucleotide, which comprises the following components in parts by weight: 20-30 parts of nicotinamide mononucleotide; 6 to 12 parts of a nano-scale fullerene inclusion; 5 to 20 parts of fructo-oligosaccharide; 6 to 17 parts of microcrystalline cellulose; 5 to 10 parts of lactose; 3 to 10 parts of mannitol; 2 to 4 parts of hydroxypropyl methyl cellulose; 0.3 to 1 part of magnesium stearate; 1-5 parts of a spina date seed extract; 1-5 parts of a ginkgo leaf extract; 3-7 parts of vitamins; and 0.5-2 parts of fruit juice concentrate. The content of nicotinamide mononucleotide can be effectively increased, the stability is enhanced, and the absorption and utilization rate is increased.

The present invention relates to a method for extracting and purifying ginkgolide B. The method comprises: (1) crushing ginkgo leaves, adding a mixed acid solution for soaking and extraction; (2) concentrating ginkgo leaf extract 1, boiling, adding talcum powder, filtering, refrigerating, and filtering; (3) adding ethyl acetate to extract 2, separating the layers, adding water, separating the layers, filtering, and spin-drying; (4) dissolving the crude extract in ethanol, eluting through a superacidic alumina chromatography column; (5) concentrating the eluate, refrigerating, filtering, and drying; (6) adding the crude ginkgolide B to a mixed solution of n-heptane and ethanol for crystallization. This method not only solves the problems of low extraction rate in steam distillation and large amount of solvent loss in organic solvent extraction, but also improves the yield of ginkgolide B while ensuring the purity of ginkgolide B. It has the advantages of simple preparation process, easy operation, low organic solvent consumption, low cost, high yield and purity, and is suitable for industrial production.

The invention relates to the technical field of fertilizers, in particular to a ginkgo leaf stock solution, a flavone-rich plant nutrition fertilizer and a preparation method and application of the ginkgo leaf stock solution and the flavone-rich plant nutrition fertilizer. The invention provides a preparation method of a ginkgo leaf stock solution, which comprises the following steps: taking pure grain white spirit as an extraction solvent, and performing stepped temperature control soaking to obtain a ginkgo leaf extracting solution; the ginkgo leaf stock solution is prepared by compounding the ginkgo leaf extracting solution with ammonium zinc sulfate, potassium alginate, humic acid and sodium dihydrogen phosphate, and the ginkgo leaf stock solution can effectively promote plant growth, improve stress resistance, increase flavone accumulation and increase yield; the ginkgo leaf stock solution and the pure grain fermentation mother solution are compounded to prepare the nutrition fertilizer, the advantages of combination of organic and inorganic components and combination of nutrition and biological stimulation are fully exerted, the content of total flavonoids in crops can be effectively increased, meanwhile, crop growth is remarkably promoted, and the crop yield is increased.

The invention relates to the technical field of preparation of bath foam, and particularly discloses bath foam capable of promoting digestion and a preparation method of the bath foam. The bubble bath liquid capable of promoting digestion comprises 305-935 parts of water, 51.7-158 parts of glycerin, 8-12 parts of a yam root extract, 3-8 parts of a radish seed extract, 1-5 parts of a wrinkled gianthyssop herb extract, 1-5 parts of a bighead atractylodes rhizome rhizome extract, 3-8 parts of a poria cocos extract, 1-5 parts of a licorice root extract, 3-8 parts of a citrus peel extract, 3-8 parts of a malt extract, 1-5 parts of a fructus forsythiae extract and 1-5 parts of a chrysanthemum extract. The composition is prepared from the following raw materials in parts by weight: 1-5 parts of ramulus uncariae tomentosae extract, 1-5 parts of radix ophiopogonis extract, 1-5 parts of herba lophatheri extract, 0.5-1.5 parts of orange peel oil, 1-3 parts of burdock seed extract, 1-5 parts of jujube extract, 0.5-1.5 parts of gleditsia sinensis seed extract and 1.9-5.9 parts of p-hydroxyacetophenone. The soup has the effects of promoting the circulation of qi, harmonizing the stomach, appetizing, removing food retention, clearing internal heat, reducing stomach fire, clearing away the heart-fire, relieving restlessness and tranquilizing by nourishing the heart.

The invention relates to the technical field of compounding of piroctone olamine salts, and particularly discloses an anti-corrosion composition containing piroctone olamine salts. The invention relates to an anti-corrosion composition containing piroctone olamine salt. The anti-corrosion composition is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of piroctone olamine salt, 30 to 40 parts of propylene glycol, 5 to 10 parts of pentanediol, 3 to 7 parts of folium ginkgo extract, 10 to 15 parts of nano zinc ricinoleate and 4 to 6 parts of sodium lauroyl sarcosinate. According to the present invention, the maximum antibacterial rates of the obtained preservative composition containing the piroctone olamine salt on malassezia furfur ATCC44344 at 5 min, 10 min and 30 min are respectively 74.2%, 95.3% and 99.9%, such that the antibacterial property of the preservative composition containing the piroctone olamine salt is improved.

The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for preventing and / or treating hypoxic injury and application, the pharmaceutical composition is prepared by compounding ginseng stem and leaf total saponins, ginkgo leaf extract and ligustrazine according to the mass ratio of (45-55): (45-55): (0.8-1.5); the hypoxia injury comprises cerebral hypoxia injury and myocardial hypoxia injury. The pharmaceutical composition provided by the invention has the functions of preventing and / or treating myocardial injury, brain tissue and motor hypofunction caused by hypoxia.

The present invention relates to the technical field of microbial fermentation, and particularly relates to an auxiliary lipid-lowering composition, a preparation method thereof, and an application thereof. A preparation method of an auxiliary lipid-lowering composition includes Step 1: First, mix apples, white hyacinth beans, red grapes, euryale ferox seeds, and lilies, then add water to form a slurry, and sterilize to obtain a fermentation substrate; Step 2: Inoculate Trichoderma reesei and ferment to obtain an initial fermented product; Step 3: Inoculate Candida krusei and ferment to obtain a second fermented product; Step 4: Take the supernatant of the second fermented product and inoculate Bifidobacterium breve, and ferment to obtain a third fermented product; Step 5: Take the third fermented product, filter and sterilize it to obtain an auxiliary lipid-lowering fermented product; Step 6: Mix the auxiliary lipid-lowering fermented product, freeze-dried natto powder, and ginkgo leaf extract evenly to obtain an auxiliary lipid-lowering composition. The auxiliary lipid-lowering composition of the present application has both safety and high bioavailability.