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Ginkgo leaf extract, injection containing said extract and its preparing method

A technology of ginkgo biloba and its extracts, which is applied in the field of traditional Chinese medicine, can solve the problems of poor water solubility, difficulty in absorption, and unfavorable clinical use, etc., and achieve the effect of clear solution, definite curative effect, and favorable clinical use

Inactive Publication Date: 2007-01-24
厦门国宇知识产权研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, there are many reports about Ginkgo biloba extract injection, such as CN1193753C discloses a kind of Ginkgo biloba injection prepared by using fresh Ginkgo biloba extract, which can greatly improve the content of total flavonoids and ginkgolides, but, due to Compared with flavonoid glycosides, flavonoids have poor water solubility and are difficult to absorb in the body. Therefore, it is more necessary to increase the content of flavonol glycosides in injections, not just the content of flavonoids
CN1517088A discloses a kind of Ginkgo biloba extract injection, this injection is to add special excipient poloxamer 188 in the commercially available Ginkgo biloba extract to make the pH of the injection alkaline, but this document does not solve the problem of Ginkgo biloba in the injection. The problem of low content of esters and flavonol glycosides, and the relatively high content of ginkgo phenols, proteins, tannins and other substances are not conducive to clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation of embodiment 1 Ginkgo biloba extract

[0063] Take 1 kg of dried ginkgo leaves, pulverize them with a pulverizer, add 60% ethanol to reflux and extract twice, each reflux extraction time is 1 hour, the amount of ethanol added each time is 5 times the weight of ginkgo leaves, filter and concentrate the filtrate to ginkgo leaves 0.3 times the weight, refrigerated for 3 hours, scraped off the oil slick, added water for injection 0.03 times the weight of ginkgo biloba each time, stirred and washed once, combined the washing liquid and the concentrated solution, added water for injection to 1 times the weight of ginkgo leaves, refrigerated for 16 hours, filtered, the filtrate was concentrated under reduced pressure to 0.2 times the weight of ginkgo leaves, put it at room temperature, added 85% ethanol to make the alcohol content to 80%, refrigerated for 16 hours, filtered, concentrated, The above-mentioned cold storage, filtration, and concentration processe...

Embodiment 2

[0065] The preparation of embodiment 2 Ginkgo biloba extract

[0066] Get dry ginkgo leaf 1kg, after pulverizing with pulverizer, add 70% ethanol reflux extraction once, reflux extraction time 2 hours, the amount of ethanol that adds is 10 times of ginkgo leaf weight, filters and concentrates filtrate to 0.8 times of ginkgo leaf weight, Refrigerate for 24 hours, scrape off the slick oil, add water for injection 0.1 times the weight of the ginkgo leaf to the scraped slick oil, stir and wash once, combine the washing liquid and the concentrated solution, add water for injection to 3 times the weight of the ginkgo leaf , refrigerated for 84 hours, filtered, the filtrate was concentrated under reduced pressure to 0.5 times the weight of ginkgo leaves, put it at room temperature, added 90% ethanol to make the alcohol content to 80%, refrigerated for 84 hours, filtered, concentrated, the above refrigeration, filtration, concentration process Repeat three times. The filtrate is adso...

Embodiment 3

[0069] The preparation of embodiment 3 Ginkgo biloba extract

[0070] Take 1 kg of fresh ginkgo leaves, crush them into a paste with a beater, add 80% ethanol to reflux and extract three times, each time for reflux extraction for 2 hours, the amount of ethanol added each time is 8 times the weight of ginkgo leaves, filter and concentrate the filtrate to ginkgo leaves 0.4 times the weight, refrigerated for 20 hours, scraped off the slick oil, added 0.04 times the weight of ginkgo leaves with water for injection, stirred and washed once, after combining the washing liquid and the concentrated solution, added water for injection to the ginkgo biloba 3 times the weight of the leaves, refrigerate for 72 hours, filter, concentrate the filtrate under reduced pressure to 0.5 times the weight of ginkgo leaves, put it at room temperature, add 95% ethanol to make the alcohol content to 80%, refrigerate for 48 hours, filter, concentrate, and refrigerate , filtering, and concentrating are ...

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Abstract

The present invention discloses a kind of ginkgo leaf extract, injection containing the said extract and its preparation process. The ginkgo leaf extract contains flavonol glycoside 18-40 wt%, bilobalide 2.5-25 wt%, and heavy metals less than 9.4 ppm, with the bilobalide comprising bilobalide A, bilobalide B and bilobalide C in the weight proportion of 7-27 to 3-20 to 4-40. The ginkgo leaf extract with high effective component content and high purity, and the prepared medicine preparation, especially injection, has obvious curative effect on cardiac and cerebral vascular diseases, clinical use safety and no side effect.

Description

technical field [0001] The present invention relates to an extract, an injection containing the extract and a preparation method thereof, in particular to a ginkgo leaf extract mainly containing ginkgolides and ginkgo total flavonol glycosides, a traditional Chinese medicine injection containing the extract and its preparation The method belongs to the field of traditional Chinese medicine. Background technique [0002] Ginkgo biloba extract can improve cardiovascular and cerebrovascular circulation, treat cardiovascular and cerebrovascular diseases, improve memory, scavenge oxygen free radicals, and delay aging. It has dual effects of treatment and health care. Ginkgo biloba injection prepared by extracting Ginkgo biloba has been used clinically for many years and has achieved good results. Its main active ingredients are total flavonol glycosides of ginkgo biloba and ginkgolides. Ginkgolides mainly include ginkgolides A, B, C, M and J, among which ginkgolide B has the hig...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/08A61P9/00A61P9/10A61K127/00
Inventor 郭东宇
Owner 厦门国宇知识产权研究有限公司
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