697 results about "Poloxamer" patented technology

The present disclosure describes pharmaceutically stable high concentration liquid formulations of antibody. Such formulations comprise, in addition to the antibody, at least one anti-aggregating agent selected from arginine or lysine, buffer and poloxamer 188. In addition, the present disclosure provides high concentrated antibody formulation having high monomer, low aggregates and desirable viscosity.

The invention provides a nitrification inhibitor and a preparation method thereof as well as stable urea and a preparation method thereof, and relates to the technical field of fertilizers. The nitrification inhibitor provided by the invention is prepared from the following components in percentage by mass: 20 to 45 percent of 3, 4-dimethyl pyrazole phosphate (DMPP), 30 to 70 percent of amino acid and the balance of auxiliaries, the auxiliary agent is one or more of polysaccharide, polyvinylpyrrolidone, poloxamer and carbomer. According to the invention, the DMPP and the amino acid are compounded, the amino acid is used as a stabilizer of the DMPP, so that the stability of the DMPP can be remarkably improved, and meanwhile, the polymer additive is used as an adhesive, so that the stability of the DMPP can be further improved. The nitrification inhibitor provided by the invention has excellent stability; the stable urea can be obtained by adopting an endogenous adding mode and adding the stable urea into the urea with relatively low loss, and the stable urea has multiple effects of improving the urea utilization rate, improving the crop quality, improving the soil biological environment, improving the soil fertility and the like.

The invention provides a neurosteroid derivative solid dispersion, a preparation method and application thereof, and a medicine containing a hot-melt extrusion solid dispersion, and belongs to the technical field of pharmacy. The preparation method comprises the following steps: carrying out melt extrusion on a raw material mixture at 125-160 DEG C to obtain the neurosteroid derivative solid dispersion, the mixed material comprises an active component, a plasticizer and a carrier material in a mass ratio of 10: (1-15): (10-90); the active component comprises at least one of a neurosteroid derivative (with a structure as shown in a formula 1), an isomer, a solvate and a pharmaceutically acceptable salt thereof; the plasticizer is selected from one or more of polyethylene glycol, poloxamer and Tween, and the average molecular weight of the polyethylene glycol is 1t; 6000, 6000; active components in the neurosteroid derivative solid dispersion exist in an amorphous state. The neurosteroid derivative in the neurosteroid derivative solid dispersion disclosed by the invention has relatively high oral bioavailability. # imgabs0 #

The invention provides a high-water-absorption sodium alginate hydrogel dressing which is composed of a solution A and a solution B. The solution A is a sodium alginate solution, and the solution B is a calcium ion solution which comprises poloxamer, zinc hyaluronate and carbomer 941. The mass concentration range of the sodium alginate solution is 1%-7%, and the concentration range of the calcium ion solution is 100-400 mM; the volume ratio of the solution A to the solution B is (1: 2)-(3: 1). The smooth and transparent moist dressing can be rapidly obtained, the dressing can be customized according to the shape and size of a wound, the moisture retention rate is 86% or above, the swelling rate is 4000% or above, wound seepage can be absorbed, the moist environment of the wound is kept, and therefore wound healing is promoted.

The invention discloses a pharmaceutical composition, a preparation containing the pharmaceutical composition, a kit containing the pharmaceutical composition, and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises the following components: an active pharmaceutical ingredient and a hot melt adhesive, wherein the mass percent of the active pharmaceutical ingredients is 0.3%-50%; the hot melt adhesive is poloxamer P188 and / or poloxamer P407; the mass percent of the hot melt adhesive in the pharmaceutical composition is 5%-30%. According to the pharmaceutical composition, the preparation containing the pharmaceutical composition and the kit containing the pharmaceutical composition, the stability of the active pharmaceutical ingredients can be improved while the active pharmaceutical ingredients are rapidly released to achieve rapid effect, swallowing of a patient can be further improved, and the medication compliance of the patient in actual taking can be improved.

The invention discloses a pharmaceutical composition, a preparation containing the pharmaceutical composition, a kit containing the pharmaceutical composition, and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises an active pharmaceutical ingredient and a hot melt adhesive, wherein the active pharmaceutical ingredient is voriconazole, and the hot-melt adhesive is selected from an A-type hot-melt adhesive, namely poloxamer P188 and / or poloxamer P407, and a B-type hot-melt adhesive, namely poloxamer P188 and / or poloxamer P407; or the B-type hot melt adhesive is polyethylene glycol 6000; the mass percent of the B-type hot melt adhesive in the pharmaceutical composition is 12%-25%; the pharmaceutical composition is a pharmaceutical composition in the form of hot-melt granulated particles. According to the pharmaceutical composition and the preparation and the kit containing the pharmaceutical composition, the stability of active pharmaceutical ingredients can be improved, swallowing of a patient can be further improved, and the medicine taking compliance of the patient during actual taking can be improved.

The invention relates to the technical field of oral membranes, in particular to a multilayer oral membrane and a preparation method thereof. The invention provides an oral membrane composition, which comprises semeglutide and pharmaceutically acceptable auxiliary materials, and is characterized in that the composition is formed by combining a drug-containing biological adhesion layer and a backing layer, and the backing layer mainly comprises a membrane forming material, a solvent and a plasticizer; the drug-containing biological adhesion layer mainly comprises semeglutide, a film-forming material, an adhesive, a pH regulator, a flavoring agent and a solvent. By preparing the double-layer oral membrane, the semeglutide is administrated through the oral cavity, and after the insoluble or slowly eroded / dissolved backing layer (preventing saliva from dissolving the medicine) and the adhesive layer containing the main medicine are combined together, the one-way delivery of the main medicine can be realized; through experiments, it is accidentally found that when temperature-sensitive materials such as poloxamer are added to be combined with a conventional adhesive for use, the residence time of the medicine in the oral mucosa can be remarkably prolonged, the curative effect of the medicine is improved, and the main mechanism is that after the medicine is administered, in the oral temperature environment, after the medicine makes contact with mucus on the surface of the oral mucosa, the oral mucosa does not adhere to the oral mucosa. And after the entanglement and piling effects among poloxamer micelles are intensified to form gel, the gel and a conventional adhesive are cooperated to improve the adhesion between the oral membrane and the oral mucosa. Besides, the medicine can be removed at any time, blood sugar can be better controlled, T2DM complications can be better reduced, a more ideal taking mode is provided for weight loss patients, and a new administration mode is provided for reducing blood sugar and reducing weight. The prepared oral cavity membrane is small in size, light in weight, thin, convenient to apply, carry and transport, safe and environmentally friendly to use and capable of meeting the requirements of old people and travelers.

The invention discloses an adapalene external preparation and a preparation method thereof, and relates to the technical field of adapalene preparation preparation. The adapalene gel comprises the following raw materials in percentage by mass: 4.5-7.5% of adapalene, 3.5-8% of a gel base material, 2-4.5% of cellulose, 0.5-2% of a penetration enhancer, 18-25% of a water-retaining agent, 2-5% of a surfactant, a pH value regulator and the balance of water, the dosage of the pH value regulator is based on the standard that the pH value of the adapalene external preparation is regulated to 7-7.5; the gel base material comprises poloxamer or carbomer, and further comprises sa-hao seed gum, and the use amount of the sa-hao seed gum accounts for 25-35% of the total mass of the gel base material. According to the adapalene external preparation provided by the invention, the irritation of adapalene to the skin is basically eliminated by utilizing the effects of the gel base material consisting of poloxamer or carbomer and sa-hao seed gum and the surfactant; the adhesive has good cohesiveness and water-retaining property, can keep the affected part moist after being smeared, promotes medicine absorption, and avoids being wiped off or automatically falling off; the stability is improved, and the medicine slow release time is indirectly prolonged.

The invention provides secondary modified silica sol and a preparation method and application thereof.The secondary modified silica sol is prepared from silica sol, a primary modified component, a secondary modified component and water, the primary modified component comprises mPEG5K-silane and poloxamer 188, and the secondary modified component comprises waterborne acrylic emulsion and span 80; the specific raw materials are adopted to carry out secondary modification on the silica sol, so that the obtained secondary modified silica sol is large in viscosity and high in adhesion, the casting back layer slurry containing the secondary modified silica sol is high in wet strength, the collapsibility of an investment casting back layer is improved, the residual strength of a shell is reduced, the quick-drying effect is strong, and the service life of the casting back layer slurry is prolonged. And in the subsequent sand cleaning process, the shell can be vibrated quickly, the residual sand powder is extremely little, the quality and performance of the material are effectively kept, the surface quality of the casting is good, the production efficiency is greatly improved, and the manufacturing cost is saved.

The invention discloses a long-acting analgesic compound as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a mixed solution containing a polymer, a local anesthetic, a non-steroidal anti-inflammatory drug and a solvent into drug-loaded microspheres through an electrostatic spraying technology; the preparation method comprises the following steps: dissolving poloxamer and a natural polymer material in water to obtain a hydrogel solution; and uniformly mixing the drug-loaded microspheres and a hydrogel solution to prepare the long-acting analgesic compound. The long-acting analgesic compound comprises drug-loaded microspheres and hydrogel, the long-acting analgesic compound and the hydrogel are both of a three-dimensional porous network structure, the drug-loaded microspheres are evenly dispersed in the hydrogel, and the drug-loaded microspheres are of a solid spherical structure. The advantages of electrostatic spraying microspheres and hydrogel are combined, the preparation method is mild in condition and simple in process, and the preparation process is non-toxic and harmless; the long-acting analgesic compound has the advantages of thermosensitivity, injectability, high drug loading rate and the like, and can be effectively applied to preparation of analgesic products.

The invention relates to the technical field of biological gel preparations, in particular to an injectable temperature-sensitive biological gel preparation as well as a preparation method and application thereof, and the injectable temperature-sensitive biological gel preparation is prepared from the following components in parts by weight: 80 to 100 parts of exosome solution, 11 to 20 parts of poloxamer and 1 to 5 parts of long-chain polysaccharide hydrophilic polymer. The stem cell exosome hydrogel injection provided by the invention is prepared from temperature-sensitive hydrogel and stem cell exosome, the temperature-sensitive hydrogel is in a liquid state at low temperature and can be sucked into the needle cylinder and injected out, and when the body surface temperature exceeds 30 DEG C, the exosome of the temperature-sensitive hydrogel can form a gel state; the exosome injection gel can be conveniently fixed at an injection part, so that the exosome can be released for a longer time, the exosome injection gel is in a liquid state during filling and injection, the operation is convenient, and when the temperature is increased to 30 DEG C after injection, the hydrogel is in a gel state and is fixedly adhered to the injection part, so that the action time of the exosome is prolonged.

The invention discloses a preparation method of praziquantel soluble powder, a liquid preparation and other dosage forms. According to the method, lactose, poloxamer, PVP (Polyvinyl Pyrrolidone) or PVA (Polyvinyl Alcohol) are used for preparing praziquantel soluble powder or a liquid preparation and other dosage forms. According to the scheme, the praziquantel preparation which is low in cost, easy and convenient to operate, high in dissolving speed and good in stability is provided.

[Problem] To provide a pharmaceutical composition containing a fusion protein comprising an antibody and a lysosomal enzyme as an active ingredient, which is stable enough to permit its distribution to the market.[Solution] A lyophilized formulation containing; a fusion protein comprising an antibody and a lysosomal enzyme as an active ingredient, and further containing a neutral salt, a disaccharide, a nonionic surfactant, and a buffer. Such a lyophilized formulation includes, for example, as an active ingredient, a fusion protein comprising an anti-transferrin receptor antibody and human iduronate-2-sulfatase, and further containing sodium chloride as the neutral salt, sucrose as the disaccharide, poloxamer as the nonionic surfactant, and phosphate buffer as the buffer.

The invention discloses a quick and long-acting gynecological antibacterial gel and a preparation method thereof. According to the formula of the gynecological antibacterial gel, a plurality of key components are selected and combined, and the gynecological antibacterial gel specifically comprises the following components in parts by weight: 5-15 parts of poloxamer, 0.5-1 part of carbomer, 0.5-1 part of N, N-dicarboxymethyl alanine trisodium salt, 0.2-0.1 part of carboxymethyl cellulose and 50-250ppm stable chlorine dioxide powder. The preparation method of the gynecological antibacterial gel comprises the five steps of chlorine dioxide chelating solution preparation, gel matrix preparation, gel forming, pH value adjustment and finished product packaging, all the steps are accurately controlled, and the product quality is ensured. The invention provides a gynecological gel product which is high in initial flowability, can be quickly gelated in vivo and has a quick long-acting antibacterial function, solves the problems of non-ideal antibacterial effect, inconvenience in use, insufficient safety and the like of an existing gynecological nursing product, ensures the safety and stability of the product, overcomes many defects of a traditional product, and has a good application prospect. And a better choice is provided for female reproductive health care.

A cannabidiol-containing hemostatic composition, comprising, in parts by mass, 0.05 to 2 parts of cannabidiol, 2 to 40 parts of Bletilla striata extract, 5 to 40 parts of Panax notoginseng extract, 5 to 40 parts of Corydalis yanhusuo extract, 20-80 parts of polyvinylpyrrolidone, 1-20 parts of poloxamer, 0.01-5 parts of an antioxidant, 0.05-10 parts of polyethylene glycol and 30-120 parts of absolute ethyl alcohol. The hemostatic composition can be used as a liquid bandage for emergency treatment of the surface of a wound on the skin.

The invention discloses an aprepitant nano suspension pharmaceutical composition and a preparation method thereof. The aprepitant nano suspension pharmaceutical composition comprises aprepitant, a space stabilizer, an electrostatic stabilizer and water, the steric stabilizer is selected from one or more of poloxamer F188, poloxamer F407 and polyvinylpyrrolidone K30, and the steric stabilizer is selected from one or more of poloxamer F188, poloxamer F407 and polyvinylpyrrolidone K30; the electrostatic stabilizer is lauryl sodium sulfate or PCM. By selecting a specific stabilizer and a preparation method, subcutaneous injection of aprepitant is realized, the stability of the medicine is remarkably improved, and the medicine loading capacity is increased. In addition, according to the method, the preparation process is simplified, the formula screening time is shortened, and therefore the overall preparation time is shortened.

The invention provides an enzyme protective agent for a continuous glucose sensor and the continuous glucose sensor, the enzyme protective agent comprises the following components: poloxamer and a zwitterionic polymer, and the mass percent concentration of the poloxamer is 0.1%-2%, and the mass percent concentration of the zwitterionic polymer is 0.5%-5%. By adopting the technical scheme provided by the invention, the poloxamer and the zwitterionic polymer are introduced, so that an enzyme layer coating process can be optimized, a coffee ring effect can be inhibited, and the consistency and monitoring accuracy of the sensor can be improved; and on the premise of keeping the signal transmission performance of the sensor unchanged, the activity and long-term stability of the biological enzyme preparation in the production, storage, transportation and use processes are remarkably improved.

The invention provides a self-assembled temperature-sensitive hydrogel for neural restoration and a preparation method thereof. The hydrogel comprises the following raw materials: poloxamer, an acellular matrix and a neural factor in a mass concentration ratio of (5-10): (10-20): (1-4), preferably 5: 15: 1. The preparation method comprises the following steps: respectively preparing a poloxamer solution and an acellular matrix solution, mixing and heating the poloxamer solution and the acellular matrix solution to form a double-network three-dimensional gel structure, adding the nerve factors, stirring or ultrasonically dispersing, and heating to form the bioactive hydrogel. The hydrogel can rapidly form a stable three-dimensional structure at the body temperature, a support is provided for nerve repair, cell adhesion and proliferation are supported, and the added nerve factors are beneficial to maintaining the activity of neurons. Meanwhile, the hydrogel is in a liquid state at a low temperature, is convenient to inject, is fixed at a body temperature, is adjustable in degradation rate, is non-toxic, is suitable for local nerve injury treatment, and improves the bioavailability and safety of a nerve repair material.

The invention discloses a novel temperature-sensitive hydrogel for liver cancer TACE treatment, and belongs to the technical field of medicines. Hydrogel is prepared from Poloxamer-407 and then mixed with Fe3O4 nano-particles to obtain the temperature-sensitive hydrogel, the temperature-sensitive hydrogel can be used as an embolism material for hepatic artery chemoembolism, intravascular embolism can be achieved, the temperature-sensitive hydrogel has degradability, permanent embolism in blood vessels is avoided, and the temperature-sensitive hydrogel can be used as an embolism material for hepatic artery chemoembolism. The development of a liver cancer treatment technology is facilitated.

Formulations for antibodies and / or antigen-binding molecules (ABMs) that bind to Porphyromonas gingivalis are described. The formulations may be used in treating infections involving P. gingivalis, such as periodontal disease. The formulations comprise at least one of histidine, saline, acetic acid, citrate phosphate, sucrose, and / or Poloxamer P188. In some embodiments, the formulations may also be pH adjusted.

The invention provides a vitamin D3 liquid composition, the vitamin D3 liquid composition comprises vitamin D3 and polyethylene glycol-15-hydroxystearate, the pH value of the vitamin D3 liquid composition is 7.1-7.6, and the vitamin D3 liquid composition does not contain ethanol, propylene glycol, polyethylene glycol, poloxamer or polyvinylpyrrolidone. The aqueous solution composition is stable and uniform, is more suitable for injection compared with an oil solution, and can be used for preventing and treating vitamin D deficiency.

A formula of the adapalene gel comprises glabridin serving as a high humectant, glycerol and butanediol, and further comprises propylene glycol, a carbomer homopolymer type C, poloxamer, disodium ethylene diamine tetraacetate, methyl p-hydroxybenzoate, a pH regulator and purified water. The content of glabridin is 1%-3%, preferably 2%. During preparation, the carbomer homopolymer C is dispersed in a uniform dispersion of propylene glycol, butanediol and glycerol under stirring, and then is hydrated with purified water under stirring. The adapalene mask has the advantages that the formula and the preparation method are reasonable in design, irritation to the skin can be effectively reduced on the premise that the treatment effect of adapalene is guaranteed, and the skin is helped to keep moisture.

The invention provides a formula of a temperature-sensitive recombinant human epidermal growth factor hydrogel composition, temperature-sensitive gel takes poloxamer as a drug carrier, and a terminal sterilization mode is filtration sterilization. The temperature-sensitive recombinant human epidermal growth factor hydrogel composition provided by the invention has unique advantages in the aspects of degerming process, temperature sensitivity, stability and practical applicability.

The invention provides a permeation promoting composition containing PDRN and glabridin and application of the permeation promoting composition in functional skin care products. The composition comprises the following components in percentage by mass: 0.01%-5% of glabridin, 0.1%-10% of glycyrrhizic acid ester stearate, 0.01%-2% of DNA sodium, 0.1%-10% of poloxamer, 0.05%-8% of carbomer, 0.5%-5% of sodium hyaluronate and the balance of one or more of water or solvents such as butanediol, glycerol, 1.3-propylene glycol and the like. In the composition, poloxamer is self-assembled in a system to form micelles, glabridin is wrapped in an inner core, and a PEO chain segment on an outer layer is combined with hyaluronic acid through a hydrogen bond to form a molecular-level wrapping structure, so that the problem of instability of glabridin is effectively solved, meanwhile, the problem of agglomeration of glabridin can be effectively avoided, and the whitening effect of glabridin is effectively promoted. Meanwhile, the glabridin, the glycyrrhizic acid ester stearate, the DNA sodium, the poloxamer, the carbomer and the hyaluronic acid are synergistically matched, so that the composition has good whitening, anti-wrinkle and penetration promoting effects.

The present invention provides an oregano essential oil inclusion complex with high encapsulation rate, high stability and anti-inflammatory and soothing effects, a preparation method and applications thereof. The composition of the oregano essential oil inclusion complex includes oregano essential oil, an encapsulating agent and an emulsifier. The emulsifier includes poloxamer, PPG-13-decyltetradeceth-24 and sodium bis(lauroylglutamyl)lysinate. The present invention does not use organic reagents such as absolute ethanol and ethyl acetate to participate in the encapsulation of oregano essential oil, which greatly ensures the safety of the oregano essential oil inclusion complex. Instead, it creatively uses common emulsifiers in cosmetics to participate in the essential oil encapsulation. The three emulsifiers cooperate with each other and have a synergistic effect in improving the encapsulation rate of oregano essential oil, enhancing the product stability and safety, so that the final encapsulation rate of oregano essential oil is as high as over 95%, and it has outstanding performance in terms of stability, safety, anti-inflammatory and soothing effects, water solubility and formulation compatibility.

Pharmaceutical composition comprising one or more cannabinoids (e.g., cannabidiol; 15-25 % w / w), one or more cyclodextrins or cyclodextrin derivatives (e.g., α-cyclodextrin (alpha-CD) or hydropropyl-β

The nitric oxide gel for treating endometrial injury is composed of a gel matrix and a nitric oxide gas solution, the nitric oxide gas solution is uniformly dispersed in the gel matrix, and the volume ratio of the gel matrix to the nitric oxide gas solution is 3: 1-1: 3. The gel matrix is composed of one or more of poloxamer and derivatives thereof, povidone, carbomer and cellulose derivatives, and the nitric oxide gas solution is formed by dispersing nitric oxide gas in absolute ethyl alcohol or water-free and oxygen-free polyhydric alcohol which is in a liquid state at the temperature of 25 DEG C. According to the nitric oxide gel for treating the endometrial injury, the limitation bottleneck of the nitric oxide gel for treating the endometrial injury is overcome, meanwhile, the safe, effective, convenient and economical requirements of clinical treatment are met, and the effect of nitric oxide on treating the endometrial injury is fully exerted.

The invention discloses an oral care composition and a method for improving the structural stability of the composition. The oral care composition comprises: 1) peroxide; 2) a fluoride ion source; 3) an antioxidant; 4) a thickening agent; 5) an orally acceptable carrier; wherein the antioxidant is prepared from one or two of butylated hydroxytoluene and butylated hydroxyanisole; and the thickening agent comprises poloxamer. Also disclosed are methods of improving the structural stability of an oral care composition comprising a peroxide and a fluoride ion source. When a fluoride ion source is added into the oral care composition containing peroxide, the composition is unstable in structure, and the paste is liquefied, while an antioxidant is further added into the formula of the oral care composition, and the antioxidant contains butylated hydroxytoluene or butylated hydroxyanisole, so that the oral care composition containing peroxide can be used for preparing the oral care composition containing peroxide. And when the thickening agent contains poloxamer, the condition that the paste structure of the composition is unstable can be improved.

The invention relates to the technical field of western-style clothes processing, in particular to an anti-wrinkle western-style clothes fabric and a processing technology thereof.The anti-wrinkle western-style clothes fabric is prepared by finishing base cloth through finishing liquid, the base cloth is wool blended fabric, and the wool blended fabric comprises wool, polyester fibers, lyocell fibers, spandex and conductive fibers; the finishing liquid is prepared from the following raw materials in parts by weight: 1 to 4 parts of polyoxyethylene sorbitan monooleate, 0.1 to 1 part of cocamidopropyl betaine, 2 to 6 parts of a fiber protecting agent, 80 to 120 parts of carboxyl-terminated hyperbranched polyester, 40 to 60 parts of butanetetracarboxylic acid, 30 to 50 parts of poloxamer, 0.1 to 2 parts of a silane coupling agent, 2 to 4 parts of an aziridine cross-linking agent and 900 to 1100 parts of water; the fabric has the advantage that the crease resistance of the business suit fabric is improved.

The invention belongs to the technical field of material sterilization, and particularly relates to application of poloxamer as an irradiation protective agent in sodium carboxymethyl cellulose hydrogel sterilization. Research finds that by adding poloxamer into sodium carboxymethyl cellulose, the poloxamer can be used as an irradiation protective agent to effectively protect sodium carboxymethyl cellulose hydrogel from being damaged by high-energy rays, so that the inherent structure and performance of the sodium carboxymethyl cellulose hydrogel are maintained, introduction of new impurities is avoided, the purity and safety of the sodium carboxymethyl cellulose hydrogel are maintained, the implementation process of protection measures is reduced, and the cost is reduced. Therefore, the method is more suitable for large-scale production, and has good practical application value.