57 results about "Alkalizing agent" patented technology

The present invention relates to a pharmaceutical composition for oral administration comprising a GLP receptor agonist or a pharmaceutically acceptable salt or derivative thereof, one or more penetration enhancers, one or more mucous membrane adhesives, and one or more basifying agents. More preferably, the penetration enhancer is a penetration enhancer based on medium chain fatty acids.

A dyeing composition for keratin fibers, including one or more first direct dyes selected from HC Blue 18, HC Red 18, HC Yellow 16, and salts thereof, one or more second direct dyes selected from Disperse Black 9, Acid Yellow 1, 2-amino-6-chloro-4-nitrophenol and salts thereof, and one or more alkalizing agents.

The invention discloses a soybean protein adhesive film and a preparation method thereof. The soybean protein adhesive film is prepared from the following raw materials: 6 parts of soybean protein, 0.1-1 part of an alkalizer, 0.5-5 parts of a protein denaturant, 1.2-2.4 parts of a polyol plasticizer and 30-60 parts of a solvent. The preparation method comprises the following steps: S1, dispersing soybean protein in a solvent to form a suspension, adding an alkalizer and a protein denaturant to obtain a mixed solution A, and heating and stirring for protein denaturation treatment to obtain a denatured soybean protein solution; s2, adding a polyol plasticizer into the modified soybean protein solution, and uniformly mixing to obtain a film forming solution; s3, coating a substrate with the film forming liquid to form a wet film; and S4, drying the wet film to obtain the soybean protein glue film. By reasonably using the basifier, the protein denaturant and the plasticizer, the solid content of the soybean protein adhesive film is improved, so that the prepared soybean protein adhesive film exists in a solid adhesive film form, the amount of water needing to be evaporated in the hot pressing process is reduced, and the problem that the solid content of traditional liquid soybean meal adhesive is low is thoroughly solved.

The disclosure relates to compositions for altering the color of keratin fibers and methods of using the compositions. The compositions comprise (a) a bonding system comprising: (i) at least one first bonding agent chosen from citric acid and / or salts thereof, and (ii) at least one second bonding agent chosen from amino acids, amino sulfonic acids, salts thereof, or combinations thereof; (b) at least one fatty alcohol; (c) at least one fatty acid; (d) at least one alkyl polyglucoside; (e) at least one alkalizing agent; and (f) at least one solvent. The compositions can further comprise one or more oxidation dyes, couplers, oxidizing agents, or combinations thereof.

Methods for treating fibromyalgia and one or more of its associated symptoms of pain, sleep disturbance and / or fatigue comprising administering to a subject in need thereof, 5.6 mg cyclobenzaprine HCl per day in one or more dosage units by transmucosal administration, the cyclobenzaprine HCl being in a form of a eutectic, and the one or more dosage units further comprising a basifying agent.

Two-component hair care product comprising separately an anhydrous carrier as a first component and an aqueous carrier as a second component, characterized in that the anhydrous carrier a) a branched or unbranched alkane having a chain length of C10 to C30, in an amount of 20 to 90 wt.%, based on the total weight of the first component, b) a branched or unbranched fatty alcohol having a chain length of C8 to C22, in an amount of 5 to 40% by weight, based on the total weight of the first component, (c) an organic acid or an alkalizing agent and d) a pH-sensitive color indicator which shows a color change in the range between pH 3 and 6, in an amount of 0.0001 to 0.05% by weight, based on the total weight of the first component, and the aqueous carrier comprises a cationic surfactant comprising an organic radical with a chain length of C12 to C30, in an amount of 0.5 to 20% by weight, based on the total weight of the second component, wherein the weight ratio of the first component to the second component is 10 to 1 to 1 to 10, further characterized in that the first component and the second component are at a temperature of 20 °C and a pressure of 10 5 Pa are liquid.

Disclosed are novel phenalene-l-one photosensitizers capable of generating singlet oxygen, compositions comprising at least one novel phenalene-l-one photosensitizer, and uses of the novel phenalene-l-one photosensitizers. The compositions are bleaching compositions, comprising at least one phenalene-l-one photosensitizer, at least one persulfate, at least one alkalizing agent and at least one peroxide source. (Formula I)

The invention relates to a solid water-dispersible pharmaceutical composition for use in the treatment of a disease, said treatment comprising dispersing said pharmaceutical composition into an aqueous liquid to produce an enteraliy administrable liquid containing at least 0.5 gram of said pharmaceutical composition and at least 0.3 g / 1 of edaravone, followed by enteral administration of said enteraliy administrable liquid to a human patient in an amount to provide a dose of 30-300 mg of edaravone, said pharmaceutical composition comprising: 2-50 weight % of 3-methyl-l-phenyl-2-pyrazolin-5-one (edaravone); and 3-50 weight % of a water-soluble alkalizing agent. This solid composition containing edaravone can be easily dispersed in an aqueous liquid to prepare an aqueous solution of edaravone that can be ingested by a patient. The solid composition of the invention provides the advantage that when the composition is introduced into water the edaravone dissolves very rapidly and the enteraliy administrable liquid thus obtained has a high oral bioavailability.

The present invention relates to a bleaching and / or lightening composition A for keratin fibres, preferably human keratin fibres, more preferably human hair, comprising: a) tris (hydroxymethyl) aminomethane and / or 2-amino-2-methyl-1, 3-propanediol, and / or salts thereof, and / or mixtures thereof; b) one or more inorganic basifying agents, c) one or more ammonium salts or alkali metal salts or alkaline earth metal salts of peroxysulfates or peroxysulfates.

The present disclosure relates to a solid oral pharmaceutical composition comprising a therapeutically effective amount of pitavastatin or a pharmaceutically acceptable salt, an alkalizing agent and colloidal silicon dioxide. Furthermore, the present disclosure also relates to said composition further comprising a therapeutically effective amount of Ezetimibe.

The present invention relates to a bleaching and coloring composition for keratin fibers, preferably for human keratin fibers, more preferably for human hair, comprising one or more alkalizing agents, one or more bleaching compounds, HC Blue 18 and / or its salts, tetrabromophenol blue and / or its salts.

The presently claimed invention relates to hair colouring formulations comprising 2-amino-1-Propanol (2A1P / Alanilol) as an alkalizing agent. The compositions of the presently claimed invention provide a series of desirable properties to the user such as a pleasant low chemical odour and a high level of hair bleaching with an acceptable damage profile. The compositions of the presently claimed invention further enable formulators to deliver a wider range of shades or colour formulations by reducing the off-toning adducts of oxidative dyes.

Compositions and Processes for Modifying Hair Color: The disclosure relates to compositions for modifying the color of keratin fibers and processes for using the compositions. The compositions include (a) a bonding system comprising (i) at least one first bonding agent selected from alpha-hydroxy acids comprising at least three hydrogen-donating carboxyl groups and / or their salts; (ii) at least one second bonding agent selected from glycine and / or its salts; and (iii) optionally, at least one third bonding agent selected from aminosulfonic acids and / or their salts; (b) at least one fatty alcohol; (c) at least one fatty acid; (d) at least one alkyl polyglucoside; (e) at least one alkalizing agent; and (f) at least one solvent. The compositions may further comprise one or more oxidation dyes, couplers, oxidizing agents, or combinations thereof. Figure: None

The present invention relates to a liquid composition for capsule filling containing acetylcysteine ​​and a soft capsule formulation containing the same. The liquid composition for capsule filling according to the present invention comprises acetylcysteine, polyethylene glycol having an average molecular weight of 300 to 600, and an alkalizing agent. The liquid composition for capsule filling according to the present invention can be used as a filler for soft capsule formulations and can improve the storage stability of acetylcysteine ​​even in the form of a liquid composition. In addition, the soft capsule formulation according to the present invention can exhibit dissolution characteristics of acetylcysteine ​​under various pH conditions.

The present disclosure relates to a solid oral pharmaceutical composition comprising a therapeutically effective amount of pitavastatin or a pharmaceutically acceptable salt, an alkalizing agent and colloidal silicon dioxide. Furthermore, the present disclosure also relates to said composition further comprising a therapeutically effective amount of Ezetimibe.

The invention discloses a method for treating dirt deposition on the secondary side of a steam generator of a nuclear power plant, which comprises the following steps of: filtering and measuring the content of corrosion products in each water supply system of the nuclear power plant by adopting a sampling device with the filtering precision less than or equal to 0.4 mu m; each water supply system of the nuclear power plant comprises a steam drainage system, a condensation water system and a main water supply system. Adding a mixed alkalizer of ethanolamine and ammonia into the steam drainage system to increase the pH value of the steam drainage system; and adding a polyacrylic acid dispersing agent into the main water supply system. By applying the secondary side dirt deposition treatment method for the nuclear power plant steam generator, secondary side dirt deposition of the nuclear power plant steam generator can be effectively reduced. Effective reduction of dirt deposition on the secondary side of the steam generator of the nuclear power plant not only facilitates prolonging of the service life of steam generator equipment, but also is the key of prolonging of the service life of the steam generator from 40 years to 60 years, and unnecessary maintenance and labor cost and overhaul period of a nuclear power unit can be saved.

The present invention relates to a dyeing composition for keratin fibers, comprising one or more alkalizing agents, HC blue 18 and / or its salts, tetrabromophenol blue and / or its salts. The present invention discloses a two-part composition, a kit and a dyeing method.

Compositions and Methods for Modifying Hair Color: This disclosure relates to compositions for modifying the color of keratin fibers and methods for using the compositions. The compositions include (a) a bonding system comprising (i) at least one first bonding agent selected from citric acid and / or salts thereof, and (ii) at least one second bonding agent selected from amino acids, aminosulfonic acids, salts thereof, or combinations thereof; (b) at least one fatty alcohol; (c) at least one fatty acid; (d) at least one alkyl polyglucoside; (e) at least one alkalizing agent; and (f) at least one solvent. The compositions may further include one or more oxidizing dyes, couplers, oxidizing agents, or combinations thereof. Figure for abstract: 1

The present invention provides an omeprazole enteric-coated capsule and a preparation method thereof. The omeprazole enteric-coated capsule comprises omeprazole enteric-coated pellets and a capsule shell. The omeprazole enteric-coated pellets sequentially comprise, from the inside to the outside: a blank drug core layer, a first protective layer, a drug-loading layer, a second protective layer, an isolation layer and an enteric-coated layer. For the omeprazole enteric-coated capsule prepared by the present invention, through the introduction of the first protective layer, the second protective layer, an alkalizing agent, etc., the drug has good stability and release property.

The present disclosure provides a particulate matter including (1) a hydrolyzed polyvinyl alcohol copolymer of vinyl acetate and one or more unsaturated acids, and (2) an alkalizing agent, and methods of manufacturing and use thereof.

The present disclosure relates to a solid oral pharmaceutical composition comprising a therapeutically effective amount of pitavastatin or a pharmaceutically acceptable salt, an alkalizing agent and colloidal silicon dioxide. Furthermore, the present disclosure also relates to said composition further comprising a therapeutically effective amount of Ezetimibe.

Compositions and Methods for Changing Hair Color The disclosure relates to compositions for changing the color of keratinous fibers and methods of using the compositions. The compositions comprise (a) a binding system comprising (i) at least one first binding agent selected from lactic acid and / or salts thereof, and (ii) at least one second binding agent selected from amino acids and / or salts thereof; (b) at least one fatty alcohol; (c) at least one fatty acid; (d) at least one alkyl polyglucoside; (e) at least one alkalizing agent and (f) at least one solvent. The compositions may further comprise one or more of oxidation dyes, couplers, oxidizing agents or combinations thereof. Figure for abstract: none

A single-agent air-oxidative hair coloring product according to an aspect of the present disclosure contains (A) gallic acid or a derivative thereof, (B) an alkalizing agent, and (C) an oxidative dye. A method for producing a single-agent air-oxidative hair coloring product containing a plurality of components including (A) gallic acid or a derivative thereof, (B) an alkalizing agent, and (C) an oxidative dye according to another aspect of the present disclosure comprises: adding component (A) to a stirring tank and stirring; adding component (B) to the stirring tank and stirring; and adding component (C) to the stirring tank and stirring. In another aspect of the present disclosure, component (A) is added to the stirring tank and stirred before component (B) is added to the stirring tank or after component (B) is added to the stirring tank and stirred.

This disclosure is also based on the discovery that it is possible to eliminate the sweetener from a fexofenadine zwitterion dihydrate suspension and still achieve satisfactory taste masking by including the sweetener solely in the external phase. In addition, this disclosure is based on the discovery that it is possible to use an inert matrix containing only mannitol when turning suspensions of fexofenadine zwitterion dihydrate into granules. Accordingly, this disclosure is directed to sugar-free chewable fexofenadine tablets comprising sprayed and dried fexofenadine granules comprising a mannitol matrix and a composition devoid of a sweetener, said composition comprising fexofenadine zwitterion dihydrate, a wetting agent, a binder, an alkalizing agent, and a buffer; and an external phase comprising a flavoring agent, a disintegrant, the wetting agent, a diluent, a sweetener, and one or more lubricant. The disclosure also includes methods of making these tablets. In one embodiment, the method of producing a sugar- free chewable fexofenadine tablet includes: generating fexofenadine granules by spraying and drying a liquid fexofenadine suspension devoid of a sweetener comprising fexofenadine zwitterion dihydrate, a wetting agent, a binder, an alkalizing agent, and a buffer onto a mannitol matrix; and compressing the fexofenadine granules with an external phase comprising a flavoring agent, a disintegrant, the wetting agent, a diluent, a sweetener, one or more lubricant.

This invention discloses a method for preparing organothioether compounds, using thiophenol compounds and olefins as raw materials, and reacting them with an alkalizing agent and a catalyst in a solvent under blue light irradiation at room temperature. The method involves using a tert-butanol salt to abstract a hydrogen atom at the S-position of R-thiophenol, generating an R-thiophenol anion. Under light irradiation, the R-thiophenol anion loses electrons to generate an R-thiophenol free radical. The R-thiophenol free radical then passes through Fe... 3+ The method involves catalytic reaction with olefins to yield organosulfur ethers. This well-designed method does not rely on halogens, is relatively reactor- and environmentally friendly, achieves a yield of up to 65%, and is cost-effective. It provides a novel approach for the synthesis of organosulfur ethers and shows promise for industrial applications.

The invention relates to the technical field of capsule preparation, and discloses a high-stability isavuconazole sulfate capsule and a preparation method thereof.The preparation method comprises the following steps that S1, isavuconazole sulfate, a polymer carrier, a disintegrating agent and a surfactant are dissolved in an organic solvent to obtain an organic phase, and a water-soluble stabilizer is dissolved in purified water to obtain a water phase; s2, dropwise adding the organic phase into the water phase by using an injection pump while stirring, continuously stirring after dropwise adding to form primary emulsion, homogenizing the primary emulsion, adding a spray drying protective agent, stirring for dissolving, performing spray drying, performing cyclone separation, collecting powder, and drying until the water content is less than or equal to 3.0 to obtain a pretreated prodrug; and S3, mixing the pretreated prodrug, a filler, an alkalizer and a lubricant, and filling a capsule shell with the mixture to obtain the capsule. The isavuconazole sulfate capsule prepared by the invention has high drug loading capacity, excellent in-vitro dissolution performance and outstanding long-term chemical and physical stability, and provides a high-quality oral preparation choice for clinic.

Disclosed are novel phenalene-1-one photosensitizers capable of generating singlet oxygen, compositions comprising at least one novel phenalene-1-one photosensitizer, and uses of the novel phenalene-1-one photosensitizers. The compositions are bleaching compositions, comprising at least one phenalene-1-one photosensitizer, at least one persulfate, at least one alkalizing agent and at least one peroxide source.

The invention provides a preparation method of modified carboxymethyl cellulose, the modified carboxymethyl cellulose and a pole piece. The preparation method comprises the following steps: S100, alkalization reaction: treating a cellulose raw material by adopting an alkalizer to obtain an alkalized material; s200, etherification reaction: treating the alkalized material with an etherifying agent to obtain modified carboxymethyl cellulose; wherein the chemical general formula of the etherifying agent is X-R-M, X is halogen, R is an organic group, and M is sulfonic acid group or sulfonate. The modified carboxymethyl cellulose obtained by the invention is used as a dispersing agent or a thickening agent used in the preparation of a pole piece, so that the direct-current internal resistance of a battery cell can be reduced.

The invention belongs to the technical field of hydroxypropyl starch ether, and relates to a preparation method of low-cost potato hydroxypropyl starch ether.The preparation method comprises the steps that an alkalizing agent, a solvent and an inhibitor are fully mixed, then potato starch is added for alkalization, then an etherifying agent is added, heating is conducted for modification, potato hydroxypropyl starch ether is obtained, and after a reaction product is subjected to desolvation, the potato hydroxypropyl starch ether is obtained. And drying is not needed, and crushing can be directly carried out. The preparation method has the advantages of small solvent addition amount, high utilization rate of the alcohol solvent and the etherifying agent, low reaction temperature and expansion pressure control, safety, high efficiency, small environmental pollution, improvement of the production stability and great reduction of the production cost; the produced product has the advantages of high hydroxypropyl content, high viscosity, high solution transparency, low ash content and the like; the process is simple, the cost is low, industrial production is facilitated, and the market prospect is wide.

An antibacterial catheter and a preparation method therefor, and an external drainage device. The antibacterial catheter (1) comprises a catheter main body, wherein the materials of the catheter main body comprise silica gel. A solvent used during the preparation process of the antibacterial catheter (1) comprises hexafluoroisopropanol. The catheter main body is swelled by means of using the solvent, such that the antibacterial agent is dispersed inside the catheter main body. The catheter main body of the antibacterial catheter (1) is swollen by means of the solvent, and the solvent used contains hexafluoroisopropanol. Hexafluoroisopropanol has a good swelling effect on a catheter main body containing silica gel, and does not require the addition of an additional alkalizing agent, penetrant or drug solubilizer, or the use of subsequent treatments, such as heating or autoclaving. The external drainage device (4) can be connected to the antibacterial catheter (1). By means of the outer drainage device (4), it is convenient to adjust the height of a drainage drip bottle (300), and the accuracy and convenience of the reading of the drainage drip bottle (300) is improved; and it is convenient fix a liquid collection bag. In addition, the structure of the outer drainage device (4) is simple.