49 results about "Thiophenol" patented technology

The application discloses a preparation method of perfluoroalkyl aryl sulfide, and a structural formula of the perfluoroalkyl aryl sulfide is shown as formula (I); the method comprises the following steps: firstly, obtaining corresponding aryl sulphenyl chloride by chlorination of thiophenol; under the condition that fluoride and crown ether exist, obtaining perfluoro-1,1-dimethylbutyl negative ion by addition of D-2 ‑ And the aryl sulphenyl chloride added is subjected to a nucleophilic substitution reaction to synthesize a product (1,1,1,3,3,4,4,5,5,5-decafluoro-2-trifluoromethylpent-2-yl)(aryl)sulfide. The application adopts a reaction strategy of efficient coupling of thiophenol and perfluoroalkyl, and can be used for preparing various fluorine-containing benzene sulfide compounds.

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

This invention provides a polynuclear metal cluster based on salicylaldehyde acetal-2-thiophenol ligand, its preparation method, and its application. The chemical formula of the polynuclear metal cluster is Co4(C 13 H9NOS)6·2CH3CN·CH3OH, where C 13 H9NOS is salicylaldehyde acetal-2-thiophenol, with Co forming a six-coordinate octahedral configuration with N, O, and S. The salicylaldehyde acetal-2-thiophenol ligand in the polynuclear metal cluster of this invention can effectively stabilize the active center of metallic cobalt, resulting in a polynuclear metal cluster with significant OER activity and broad prospects for practical applications.

The application belongs to the technical field of biological medicine, and discloses a synthesis method of aryl F-18 labeled sulfuryl chloride and application of the aryl F-18 labeled sulfuryl chloride in amine compound labeling. The method takes thiophenol derivative as a labeling precursor, obtains F-18 labeled thiophenol intermediate through photocatalytic aryl F-18 fluorination reaction, and then obtains aryl F-18 labeled sulfuryl chloride through N-chlorosuccinimide oxidation chlorination. The obtained aryl F-18 labeled sulfuryl chloride (4-[ 18 F] fluorobenzenesulfonyl chloride) can occur sulfurylization reaction with various amine compounds at room temperature, and the radiochemical conversion rate is as high as 98%. The application is successfully applied to novel synthesis of AMPA receptor PET imaging agent[ 18 F]2 (the conversion rate is 96%, which is much higher than 13% reported in the literature). The application has the advantages of mild reaction condition, high conversion rate and wide substrate application range, and provides an efficient method for innovative preparation of F-18 labeled PET probes.

The invention relates to the field of rubber materials, and particularly discloses a golf ball inner core material, a preparation method thereof and a high-elasticity golf ball. The invention discloses an inner core material of a golf ball. The inner core material comprises the following raw materials in parts by weight: 100 parts of butadiene rubber, 25-30 parts of zinc acrylate, 0.5-1.5 parts of a vulcanizing agent, 4-8 parts of zinc stearate, 0.4-0.8 part of pentachlorothiophenol, 4-8 parts of zinc oxide and 15-20 parts of filler. The golf ball inner core material has the advantages of being good in rebound resilience and good in hitting resistance, the service life can be prolonged, and a better ball hitting feeling can be brought.

The invention discloses a thiophenol-heptamethine cyanine dye derivative as well as self-assembled nanoparticles, a preparation method and application thereof. The derivative is a thiophenol-heptamethine cyanine dye monomer derivative or a 1, 3, 5-benzene trithiophenol-heptamethine cyanine dye triad derivative; the thiophenol or the 1, 3, 5-benzene trithiophenol is connected with a meso-carbon atom of the heptamethine cyanine dye through a sulfur atom, and the heptamethine cyanine dye is formed by connecting two nitrogen-containing heterocyclic ring units through a conjugated methine chain; the nanoparticles are obtained by dropwise adding a derivative solution into water and then removing an organic solvent. The synthesis method of the thiophenol-cyanine dye derivative is simple and easy to implement, stable nanoparticles can be formed, the tumor targeting property can be improved, the aggregation effect far better than that driven by traditional weak interaction is achieved, synchronous optimization of high tumor accumulation and extremely high heat production efficiency is successfully achieved through self-assembly of nanoparticles, and the thiophenol-cyanine dye derivative has good application prospects. An innovative strategy is provided for the development of a high-performance tumor photo-thermal reagent.

The invention discloses an efficient and simple synthesis method of a dibenzotetrathiafulvalene derivative, which is characterized in that benzene-1, 2-thiophenol or a derivative of benzene-1, 2-thiophenol is subjected to dimerization in a solvent containing acetic acid under a solvothermal reaction condition to obtain the dibenzotetrathiafulvalene or the derivative of dibenzotetrathiafulvalene. The solvothermal reaction conditions are mild, the operation is simple, and the method is suitable for large-scale preparation and environment-friendly. No toxic by-product is generated in the reaction, the reaction product does not need to be purified, the high-purity crystal compound can be obtained, the product efficiency is improved, and the selectivity is guaranteed.

The application discloses a metal organic complex with controllable morphology and a preparation method thereof, and belongs to the technical field of metal organic complex preparation. The preparation method of the metal organic complex with controllable morphology comprises the following steps: dissolving cuprous oxide and 4-hydroxythiophenol in anhydrous ethanol to form a mixed solution A; circulating nitrogen into the mixed solution A and performing air extraction and inflation to obtain a mixed solution B; and performing a heating reaction on the mixed solution B under stirring to obtain a reaction liquid capable of controlling the morphology of the metal organic complex; wherein the morphology of the metal organic complex is controlled by controlling the heating reaction time; and the reaction liquid is sequentially filtered, washed and dried to obtain the metal organic complex, wherein the morphology of the metal organic complex is linear or flaky. According to the method, linear or flaky two completely different morphologies can be stably and controllably obtained by only adjusting the heating reaction time, and the flexibility and convenience of morphology control are remarkably improved.

The invention discloses a preparation method of hydrobromic acid vortioxetine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking o-aminothiophenol and Boc2O as initial raw materials, carrying out amino protection to obtain an intermediate 1; reacting the intermediate 1 with 2, 4-dimethyl bromobenzene under an alkaline condition to form a thioether bond, and acidifying to obtain an intermediate 2; carrying out high-temperature cyclization on the intermediate 2 and bis (2-bromoethyl) amine hydrobromide in mesitylene, so as to obtain a crude product of the hydrobromic acid vortioxetine; and recrystallizing the crude product with 95% ethanol to obtain a high-purity final product. The route is simple, only three-step reaction is needed, a noble metal catalyst is not needed in the whole process, and the problem of metal residues is fundamentally avoided; the selected raw materials are easy to obtain, the reaction condition is mild, the operation is simple and convenient, the process is stable, the total yield is good, the product purity is as high as 99.9%, and the method is suitable for large-scale production.

The application discloses an aggregation-induced emission material with high fluorescence quantum yield and large stokes shift, a preparation method and application thereof, and belongs to the technical field of preparation of the aggregation-induced emission material. The preparation method comprises the following steps: obtaining an intermediate by means of Suzuki-Miyaura coupling reaction of an organic boric acid and bromosalicylaldehyde; and adding the intermediate, sodium metabisulfite and aminophenylthiophenol into an organic solvent, and then performing high-temperature reaction to prepare the aggregation-induced emission material. The aggregation-induced emission material is synthesized by means of a two-step method, can be rapidly and mass-produced, and has the advantages of high fluorescence efficiency, large stokes shift, good stability and the like.

The present application relates to the determination of pentachlorothiophenol in rubber, comprising the following steps: (1) pyrolysis gas chromatography mass spectrometry test standard solution; (2) draw standard curve; (3) sample test; (4) sample qualitative judgment; (5) sample quantitative calculation result. The present application optimizes the quantitative method of pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) for detecting the content of pentachlorothiophenol in rubber products, and quickly confirms the content of pentachlorothiophenol in rubber products.

This invention discloses a method for preparing co-assembled nanoparticles of thiophenol-heptamethine dye monomer and its triplet derivative, as well as their applications. The co-assembled nanoparticles comprise thiophenol-heptamethine dye monomer and a triplet derivative. The derivative is formed by linking the sulfur atom of thiophenol to the middle carbon atom of heptamethine dye, and the heptamethine dye is formed by two nitrogen-containing heterocyclic units linked by a conjugated methylene chain. The method involves mixing solutions of the two derivatives and adding them dropwise to water, followed by removal of the organic solvent to obtain co-assembled nanoparticles with uniform particle size. This invention significantly enhances the assembly stability of the nanoparticles while successfully retaining the excellent photothermal conversion efficiency of the triplet derivative, overcoming the technical bottleneck of the difficulty in stabilizing high-heat-generating molecules into particles. It achieves synergistic optimization of the assembly stability and photothermal efficiency of photothermal reagents, providing a novel design strategy and technical support for the development of high-performance tumor photothermal therapy drugs.

This invention discloses an internal standard-assisted petal-shaped SERS nanoprobe, its preparation method, and its applications. The internal standard-assisted petal-shaped SERS nanoprobe of this invention is a core-molecule-shell structure gold nanoprobe consisting of a gold nanosphere core, an internal standard modifying molecule, a petal-shaped gold nanoshell, and a recognition molecule, 4-nitrobenzenethiophenol. The internal standard modifying molecule is a Raman signal molecule with nitrile, alkyne, or azide functional groups. This invention uses a Raman signal molecule as an internal standard modifying molecule to modify the gold nanosphere core. The corrected working curve exhibits good reproducibility and small error, improving the reliability of the detection results. Growing a petal-shaped gold nanoshell on the molecular layer of the internal standard modifying molecule enhances the SERS activity both inside and outside the SERS substrate, and the petal-shaped shell increases the surface area of ​​the SERS substrate. Furthermore, the recognition molecule of this invention enables ratiometric Raman detection of hydrogen sulfide, effectively reducing background signal interference and improving detection sensitivity.

The invention discloses a synthesis method of diaryl methyl sulfide under a biological compatibility condition, which comprises the following steps: adding a p-methylene benzoquinone derivative and a thiophenol thiol derivative into a reaction solvent, stirring and reacting for 4 hours at room temperature to obtain a reaction solution, filtering and removing the reaction solvent of the reaction solution to obtain diaryl methyl sulfide. And purifying by thin layer chromatography / column chromatography to obtain the diaryl methyl thioether compound. The p-methylene benzoquinone derivative used in the method is easy to synthesize, high in conversion rate and wide in applicable substrate range, and in addition, the method is simple in step, convenient to operate and high in product yield, does not use any metal compound, and has the advantages of being high in atom economy and environmentally friendly.

This invention belongs to the field of electrocatalytic materials technology, and relates to a nitrogen-sulfur co-doped mesoporous carbon catalyst, its preparation method, and its application. The catalyst is a nitrogen-sulfur co-doped carbon-based material, obtained by self-assembly and high-temperature carbonization using F127 as a template agent and m-aminothiophenol as a precursor. The catalyst possesses abundant active sites, optimized electronic structure, and mesoporous morphology, exhibiting high activity, high selectivity, and excellent stability in the electrocatalytic oxygen reduction reaction, making it suitable for efficient and environmentally friendly electrosynthesis of hydrogen peroxide.

This invention relates to a method for preparing and applying an ordered silver nanoparticle@bismuth nanosheet@copper mesh array. First, bismuth nanosheets are grown on the surface of a copper mesh through an etching reaction using an immersion method. Then, silver nanoparticles are sputtered onto the surface of the bismuth nanosheets, resulting in an ordered silver nanoparticle@bismuth nanosheet@copper mesh array film. This array film is then immersed in a 4-p-aminobenzaldehyde (4-ABZ) solution, adsorbing 4-ABZ molecules onto the surface of the silver nanoparticle@bismuth nanosheet@copper mesh array as signal probe molecules. The silver nanoparticle@bismuth nanosheet@copper mesh array with adsorbed 4-ABZ molecules is then placed as a substrate in a packaging environment containing seafood, meat, or other meat-derived foods. The SERS signal intensity of the 4-ABZ molecules on the substrate surface is used to monitor the freshness of the meat-derived foods. As the freshness of the meat-derived foods decreases, the SERS signal of the 4-ABZ molecules on the substrate surface gradually decreases. Meanwhile, the silver nanoparticle@bismuth nanosheet@copper mesh array also exhibits excellent SERS signal response and signal uniformity for organic dye pollutant molecules such as rhodamine 6G and 4-aminobenzylthiophenol (4-ATP), and has important application prospects in the field of environmental monitoring.

The invention relates to the technical field of nanometer material synthesis and catalysis, in particular to a gold nanocluster and a preparation method thereof, a catalyst and a preparation method and application of the catalyst. The molecular formula of the gold nanocluster is Au40 (TBBT) 24 (TPMP); wherein the TBBT is 4-tert-butyl thiophenol, and the TPMP is tri (m-phenyl) phosphine. According to the present invention, the gold nano-particles have the accurate number of atoms and the determined molecular structure, the synergistic effect of the mixed ligands (mercaptan and phosphine) on the surface of the gold atomic nucleus further regulates the electronic structure and the surface property of the cluster, and the adsorption and activation ability of the substrate molecule is optimized so as to improve the catalytic efficiency and the stability; especially for reduction reactions such as reduction of 4-nitrophenol, the cluster can realize efficient catalytic conversion under mild conditions.

This invention discloses a fluorescent probe for detecting hypochlorite based on the synergistic effect of ESIPT and AIE in a benzothiazole structure, its preparation method, and its application, belonging to the field of fluorescent probe technology. The invention uses 2-aminobenzylthiophenol and 2-hydroxy-5-methoxybenzaldehyde as starting materials, condensing them to form a benzothiazole derivative as the fluorescent core. A diaminomaleitrile recognition group is introduced through an aldehyde-amine condensation reaction to synthesize the fluorescent probe. After the probe undergoes a specific oxidation reaction with hypochlorite, the C=N double bond breaks, and the ESIPT and AIE effects are synergistically activated, resulting in a significant enhancement of fluorescence. This probe exhibits a fast response, a linear range of 0-200 μM, a detection limit of 29.1 nM, excellent selectivity and anti-interference properties, and stability under pH 6-10 conditions, making it suitable for highly sensitive detection of hypochlorite in aqueous solutions and complex systems.

The invention provides a diesel engine lubricating oil composition and a preparation method thereof. The diesel engine lubricating oil composition of the present invention comprises: (A) a viscosity index improver; (B) a boronized ashless dispersant and / or a polyisobutylene succinate ashless dispersant; (C) sulfonate and / or sulfurized alkylphenate metal detergents; (D) zinc dialkyl dithiophosphate; (E) a dialkyl dithiocarbamate; (F) an amine type antioxidant; (G) a thiophenol ester type antioxidant; (H) lubricating base oil; wherein the viscosity index improver is a copolymer of methyl acrylic acid C8-C12 alkyl ester, methyl acrylic acid C13-C18 alkyl ester and N-vinyl imidazole. The diesel engine lubricating oil composition has excellent soot dispersion, wear resistance and high-temperature cleaning performance, and can meet the requirements of API CI-4, ACEA E4 and E7-grade high-performance diesel engine lubricating oil.

The invention belongs to the technical field of natural compounds, pharmaceutical and chemical intermediates and related chemistry, and discloses a method for selective alkylation of substituted thiophenol, which is characterized in that substituted thiophenol is used as a raw material, sodium borohydride is used as a reduction polymerization inhibitor, quaternary ammonium salt is used as an alkylation reagent, and the substituted thiophenol is prepared by selective alkylation in a solvent in the presence of alkali. The method provided by the invention has the advantages of high product selectivity and simple operation and post-treatment. The addition of sodium borohydride reduces and inhibits polymerization of the raw materials, greatly improves the conversion rate and yield of the reaction, reduces the synthesis cost, and provides possibility for industrialization. Meanwhile, the use of a high-activity and high-toxicity methylation reagent is avoided, and the environmental harm is reduced.

The invention belongs to the technical field of synthesis of organic compounds, and provides a novel method for preparing a 3-thiophenyl indole nitrogen heterocyclic compound. According to the method, under the conditions of acid and illumination, dimethyl sulfoxide serves as a green oxidizing agent, direct coupling of an indole compound and a thiophenol compound is utilized, a direct oxidative dehydrogenation coupling mode is adopted, reaction functional groups do not need to be configured in advance, conversion to the 3-thiophenyl indole nitrogen heterocyclic compound is achieved in one step, raw materials are cheap and easy to obtain, conditions are mild and green, and the method is suitable for industrial production. The method is simple and safe to operate and has a relatively high economic prospect.

The invention belongs to the technical field of electro-catalytic materials, and relates to a nitrogen-sulfur co-doped mesoporous carbon catalyst and a preparation method and application thereof, the catalyst is a nitrogen-sulfur co-doped carbon-based material, and is obtained through self-assembly and high-temperature carbonization treatment by taking F127 as a template agent and taking m-aminothiophenol as a precursor. The catalyst has abundant active sites, an optimized electronic structure and mesoporous morphology, shows high activity, high selectivity and excellent stability in an electrocatalytic oxygen reduction reaction, and is suitable for an efficient and environment-friendly hydrogen peroxide electrosynthesis process.

This invention discloses a method for preparing sulfur-containing ether compounds, comprising the following steps: in the presence of sodium hydride and lithium iodide, o-iodoaryl ether undergoes a coupling reaction with thiophenol or thiol to prepare the sulfur-containing ether compound. This invention prepares aryl sulfides from o-iodoaryl ether and thiophenol / thiol under NaH and LiI conditions. Compared with other conventional methods, this method does not require transition metal catalysis, has mild reaction conditions, and is simple to operate, providing a novel method for synthesizing sulfur-containing ether compounds with broad application prospects.

The invention relates to application of an amide ligand and a copper catalyst in preparation of thioether compounds. The compound is prepared from a substituted aromatic polyhalide compound and a thiophenol compound through a reaction under the action of an amide ligand and a cuprous catalyst, R1-X + R2SH-> R1-SR2, the structural formula of the amide ligand is shown in the specification, and the cuprous catalyst is cuprous halide or cuprous oxide.

The invention belongs to the field of functional dyes in fine chemical engineering, and particularly relates to a novel near-infrared aggregation-induced emission dye and a probe as well as a preparation method and application of the novel near-infrared aggregation-induced emission dye. The near-infrared aggregation-induced emission dye provided by the invention has double-electron donor characteristics of triphenylamine and thiophene, can emit near-infrared aggregation-induced fluorescence with a peak value of 660nm in an aqueous solution, has an excitation wavelength in a visible light region, and has relatively small background fluorescence and scattering signals. The near-infrared aggregation-induced emission probe provided by the invention belongs to a lightening type fluorescent probe, has high specificity and detection speed on 2, 6-dimethylthiophenol, and has practical application value in food samples.

This invention discloses a method for preparing organothioether compounds, using thiophenol compounds and olefins as raw materials, and reacting them with an alkalizing agent and a catalyst in a solvent under blue light irradiation at room temperature. The method involves using a tert-butanol salt to abstract a hydrogen atom at the S-position of R-thiophenol, generating an R-thiophenol anion. Under light irradiation, the R-thiophenol anion loses electrons to generate an R-thiophenol free radical. The R-thiophenol free radical then passes through Fe... 3+ The method involves catalytic reaction with olefins to yield organosulfur ethers. This well-designed method does not rely on halogens, is relatively reactor- and environmentally friendly, achieves a yield of up to 65%, and is cost-effective. It provides a novel approach for the synthesis of organosulfur ethers and shows promise for industrial applications.

The invention discloses a polysulfide aromatic hydrocarbon compound as well as a preparation method and application thereof in detection of polarity and / or viscosity, and belongs to the technical field of fine chemical engineering. The polysulfide aromatic hydrocarbon compound takes a benzene ring as a core, six thiophenol substituent groups are introduced around the benzene ring, then six galactose groups are modified, and the structure of the polysulfide aromatic hydrocarbon compound is shown as a formula (I). The compound has the property of light excitation induced aggregation luminescence, and does not emit light when being dispersed in water. Under the illumination of 365 nm, the luminescence of the compound is enhanced, and the compound can be used for detecting polarity and viscosity. Along with reduction of environmental polarity, the luminescence enhancement multiple of the compound is increased, and blue shift is carried out from 515 nm to 482 nm. Along with the increase of environmental viscosity, the luminous enhancement multiple of the compound at 500nm is increased. (I)

The invention discloses a method for reducing a nitro compound into amine by formate under photocatalysis. According to the method, an aromatic nitro compound or an aliphatic nitro compound is subjected to a reduction reaction under the protection of inert gas by taking dimethyl sulfoxide as a reaction medium, taking formate as a hydrogen donor and a reducing agent and taking mercaptan or thiophenol as a hydrogen atom transfer reagent under the conditions of visible light irradiation and heating; a corresponding aromatic amino compound or aliphatic amino compound is formed. According to the method, visible light is adopted to induce reduction of the nitro compound, so that the reaction efficiency is improved, the use of a photocatalyst is avoided, dangerous articles such as hydrogen or complex reducing agents do not need to be added, transition metal and acid substances do not participate in the reaction process, and generation of transition metal waste and waste acid is avoided.

The invention belongs to the technical field of chemical synthesis of drugs, and particularly discloses a novel synthetic route of an anti-hyperuricemia drug dotinirad (Dotinirad, the CAS number is 1285572-51-1, and the chemical name is 3-(3, 5-dichloro-4-hydroxybenzoyl)-1, 1-dioxo-2, 3-dihydro-1, 3-benzothiazole). The invention further discloses a preparation method of the dotinirad, the CAS number is 1285572-51-1, and the chemical name is 3-(3, 5-dichloro-4-hydroxybenzoyl)-1, 1-dioxo-2, 3-dihydro-1, 3-benzothiazole. According to the route, p-hydroxybenzoic acid which is low in price and easy to obtain serves as a starting raw material, a target product is obtained through four-step reaction of chlorination, acylating chlorination, amide condensation and oxidation, the method has the advantages of being short in step, mild in condition and high in yield, use of 2-aminothiophenol which is odorous and unstable is avoided, benzothiazole which is more stable and low in price is used as a raw material, and the method is suitable for industrial production. The concept of green chemistry is met. The industrial production cost is remarkably reduced, and an efficient and reliable technical scheme is provided for large-scale production of the dotenorad.