137 results about "Thiophenol" patented technology

The invention discloses a preparation method of a dotenorad key intermediate, and belongs to the technical field of compound synthesis. In the preparation method of the dotenorad key intermediate, provided by the invention, 2-aminothiophenol and formaldehyde are used as raw materials to carry out cyclization reaction to prepare a compound as shown in a formula 1, and then the compound as shown in the formula 1 and 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3, 3 According to the method, 3-(3, 5-dichloro-4-methoxybenzoyl chloride)-2, 3-dihydro-1, 3-benzothiazole is used as a raw material, an amidation reaction is carried out on 3, 5-dichloro-4-methoxybenzoyl chloride in an aqueous solution of an organic solvent, and the key intermediate 3-(3, 5-dichloro-4-methoxybenzoyl)-2, 3-dihydro-1, 3-benzothiazole of dotenorad can be effectively prepared; the obtained dotenorad key intermediate is relatively high in yield and purity; moreover, benzothiazoline which is widely used in the prior art does not need to be used in the preparation method, an activating agent or a solubilizer does not need to be used, the operation method is simple, reaction conditions are mild, and the method is suitable for actual industrial production.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for detecting related substances in 2-aminothiophenol. According to the detection method of the 2-aminothiophenol related substances, provided by the invention, a reversed-phase HPLC (High Performance Liquid Chromatography) determination method is provided, the detection of the 2-aminothiophenol related substances can be realized, the specificity, linearity, precision, sensitivity, precision and durability of the method are good, and the method is suitable for quality control of 2-aminothiophenol.

The invention is applied to the technical field of compound preparation, and discloses a synthesis method of o-aminothiophenol, which comprises the following steps: uniformly mixing 2-chloronitrobenzene, water and strongly basic anion exchange resin, heating, dropwise adding a hydrosulfide aqueous solution, carrying out heat preservation reaction, cooling and filtering after the reaction is finished, and drying to obtain the o-aminothiophenol. Eluting the filter cake with liquid alkali, acidifying and layering to obtain an o-aminothiophenol crude product, and distilling to obtain the product. The thiophenol and the basic group of the resin are salified, the main reaction for generating 2-nitrothiophenol is promoted in the early stage, and the generation of a nitroreduction byproduct 2-aminochlorobenzene is greatly reduced, so that the product yield is greatly improved; the product stability is improved by salifying, so that disulfides are prevented from being formed by bimolecular oxidation of thiophenol, reduction is not needed, the product can be obtained by acidification after alkali elution, the process is shortened, and the cost is reduced; the production process is simple to operate, pressure reaction is avoided, the requirement on equipment is low, and the yield is high and can reach 95% or above; the purity of the obtained product can reach 99% or above.

The application discloses a preparation method of perfluoroalkyl aryl sulfide, and a structural formula of the perfluoroalkyl aryl sulfide is shown as formula (I); the method comprises the following steps: firstly, obtaining corresponding aryl sulphenyl chloride by chlorination of thiophenol; under the condition that fluoride and crown ether exist, obtaining perfluoro-1,1-dimethylbutyl negative ion by addition of D-2 ‑ And the aryl sulphenyl chloride added is subjected to a nucleophilic substitution reaction to synthesize a product (1,1,1,3,3,4,4,5,5,5-decafluoro-2-trifluoromethylpent-2-yl)(aryl)sulfide. The application adopts a reaction strategy of efficient coupling of thiophenol and perfluoroalkyl, and can be used for preparing various fluorine-containing benzene sulfide compounds.

The present invention relates to a method for enhancing the photooxidative coupling reaction of 4-aminothiophenol and its application, the method comprising: adding 4-nitrothiophenol to the photocatalytic oxidative coupling reaction system of 4-aminothiophenol, performing a catalytic reaction under the mediation of 4-nitrothiophenol, and oxidizing 4-aminothiophenol to 4,4'-dimercaptoazobenzene. The present invention proposes for the first time to enhance the photooxidative coupling reaction of 4-aminothiophenol by the mediation of 4-nitrothiophenol, which can be judged by the phenomenon that the Raman characteristic peak intensity of the photooxidative coupling product 4,4'-dimercaptoazobenzene is significantly enhanced, and it is found that the Raman characteristic peak intensity under the method is significantly greater than the linear sum of the characteristic Raman peak intensities of 4,4'-dimercaptoazobenzene detected by the catalytic reaction of two thiophenols alone. The method provides a new idea for enhancing and regulating the photooxidative coupling of 4-aminothiophenol.

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

The invention discloses a preparation method of an Elobixibat intermediate 2, 4-dibromo-5-methoxybenzene sulfonyl chloride (I), and belongs to the field of preparation of drug intermediates. The method comprises the following steps: oxidizing 3-methoxythiophenol serving as a raw material with hydrogen peroxide to generate a compound II, halogenating the compound II with bromine to generate a compound III, and finally oxidizing and chlorinating with zirconium chloride and hydrogen peroxide to generate the compound 2, 4-dibromo-5-methoxybenzenesulfonyl chloride (I). The preparation method of the intermediate compound III has the advantages of stable property, high yield, high purity, good product appearance, simple post-treatment, suitability for industrial production and the like.

This invention provides a polynuclear metal cluster based on salicylaldehyde acetal-2-thiophenol ligand, its preparation method, and its application. The chemical formula of the polynuclear metal cluster is Co4(C 13 H9NOS)6·2CH3CN·CH3OH, where C 13 H9NOS is salicylaldehyde acetal-2-thiophenol, with Co forming a six-coordinate octahedral configuration with N, O, and S. The salicylaldehyde acetal-2-thiophenol ligand in the polynuclear metal cluster of this invention can effectively stabilize the active center of metallic cobalt, resulting in a polynuclear metal cluster with significant OER activity and broad prospects for practical applications.

The invention discloses a benzothiazole-tetraphenyl ethylene derivative as well as a preparation method and anti-counterfeiting application thereof, 4-(1, 2, 2-triphenyl vinyl) acetophenone and o-aminothiophenol are reacted in dimethyl sulfoxide by taking I2 as a catalyst, and after the reaction is finished, separation and purification are performed to obtain a compound molecule 1-1. And 2, carrying out heating reaction on the obtained compound 1-1 and malononitrile under the action of alkali and a solvent, and separating and purifying to obtain a compound 1-2. The compound disclosed by the invention is low in preparation cost, simple and convenient to operate and simple in method, the compound shows fluorescence characteristics and can be applied to the fields of printing and dyeing, printing ink, cosmetics and the like, and meanwhile, the synthesis method can be used for synthesis in the fields of fine organic chemical engineering such as luminescent materials and trace detection technologies.

The invention discloses a method for efficiently preparing benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures by catalyzing aromatic benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide and NHC catalytic oxidation cross dehydrogenation coupling of amine, alcohol, phenol, thiol and thiophenol through carbene, and is characterized in that benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide, a nucleophilic reagent, a carbene catalyst and alkali are used as raw materials for preparing the benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivatives with various structures. The preparation method comprises the following steps: putting benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide as a raw material, an oxidant and a solvent in an air atmosphere, reacting at room temperature or under a heating condition, removing the solvent in vacuum to obtain a coarse material, and performing silica gel column chromatography purification on the coarse material to obtain the target compound benzo [e] [1, 2, 3] oxathiazide 2, 2-dioxide derivative. The reaction is carried out under extremely mild conditions, the substrate range is wide, and the tolerance of functional groups is good. In addition, the biological activity research of the target compound shows that the compound has the potential of being developed into an effective antifungal agent for crop protection. The compound can be used as a potential candidate drug for inhibiting phytopathogen fungi, and has good research and development value.

The invention discloses a surface-enhanced Raman probe as well as preparation and application thereof. The surface-enhanced Raman probe comprises a silver nanorod and a 4-amino thiophenol molecular layer adsorbed on the surface of the silver nanorod, pATP molecules and the surface of the silver nanorod form an Ag-S bond through sulfydryl (-SH) to form AgNRs (at) PATP, the two AgNRs (at) PATP molecules easily form a corresponding azo compound DMAB, and a pi-pi conjugated structure between the DMAB and nitro explosive molecules can effectively promote electron transfer, combine into AgNRs (at) PATP (at) TNT and generate a hot spot signal, so that a Raman signal is enhanced, the detection limit is reduced, the accuracy is high, and the method is suitable for industrial production. The trace detection of the nitro explosives is realized.

The present application relates to the fine chemical technology field, specifically to a kind of preparation of bis (4-tolyl sulfenyl) di-deuteromethane method.The domestic research and synthesis of bis (4-tolyl sulfenyl) di-deuteromethane are less reported, only a few foreign literatures provide corresponding preparation method.Aiming at the above problems, the present application provides a kind of preparation of bis (4-tolyl sulfenyl) di-deuteromethane method, the present application is reacted by 4-methyl phenyl sulfenol and 1-(chloro di-deuteromethyl)-1,4-diazabicyclo [2.2.2] octane-1-ammonium chloride in the acetonitrile solution containing HI, bis (4-tolyl sulfenyl) di-deuteromethane is successfully prepared, the synthetic route of the present application is simple and efficient, raw material is easy to obtain, and has good commercial value.

The application belongs to the technical field of biological medicine, and discloses a synthesis method of aryl F-18 labeled sulfuryl chloride and application of the aryl F-18 labeled sulfuryl chloride in amine compound labeling. The method takes thiophenol derivative as a labeling precursor, obtains F-18 labeled thiophenol intermediate through photocatalytic aryl F-18 fluorination reaction, and then obtains aryl F-18 labeled sulfuryl chloride through N-chlorosuccinimide oxidation chlorination. The obtained aryl F-18 labeled sulfuryl chloride (4-[ 18 F] fluorobenzenesulfonyl chloride) can occur sulfurylization reaction with various amine compounds at room temperature, and the radiochemical conversion rate is as high as 98%. The application is successfully applied to novel synthesis of AMPA receptor PET imaging agent[ 18 F]2 (the conversion rate is 96%, which is much higher than 13% reported in the literature). The application has the advantages of mild reaction condition, high conversion rate and wide substrate application range, and provides an efficient method for innovative preparation of F-18 labeled PET probes.

The invention relates to the field of rubber materials, and particularly discloses a golf ball inner core material, a preparation method thereof and a high-elasticity golf ball. The invention discloses an inner core material of a golf ball. The inner core material comprises the following raw materials in parts by weight: 100 parts of butadiene rubber, 25-30 parts of zinc acrylate, 0.5-1.5 parts of a vulcanizing agent, 4-8 parts of zinc stearate, 0.4-0.8 part of pentachlorothiophenol, 4-8 parts of zinc oxide and 15-20 parts of filler. The golf ball inner core material has the advantages of being good in rebound resilience and good in hitting resistance, the service life can be prolonged, and a better ball hitting feeling can be brought.

The invention relates to a method for adsorbing sulfydryl or thiophenol molecules on the surface of a platinum catalyst to enhance electro-catalysis formic acid oxidation and methanol oxidation, in particular to a method for enhancing formic acid and methanol electro-oxidation reaction by modifying a platinum electrode with cysteamine molecules to form a platinum-cysteamine heterogeneous interface, and belongs to the technical field of catalytic energy. According to the invention, mercaptan / thiophenol molecules represented by cysteamine (CYS) are modified on the surfaces of platinum nanoparticles through chemical adsorption, so that a molecule-metal composite catalytic system with an optimized electronic structure is constructed. X-ray photoelectron spectroscopy, in-situ Raman spectroscopy and theoretical calculation prove that the catalytic performance of surface adsorption molecules is remarkably improved through a dual-action mechanism, on one hand, the electronic structure of platinum is regulated and controlled to reduce a reaction energy barrier, on the other hand, interface charge transfer kinetics is promoted, and the oxidation process of formic acid through a formate path is effectively optimized. The technical scheme has universality to various mercaptan / thiophenol molecular systems, and the strategy can also be used for improving the performance of methanol oxidation reaction. The invention provides a novel catalytic material system for developing efficient direct formic acid and methanol fuel cells, and has important application value in the field of clean energy conversion devices.

The invention discloses a thiophenol-heptamethine cyanine dye derivative as well as self-assembled nanoparticles, a preparation method and application thereof. The derivative is a thiophenol-heptamethine cyanine dye monomer derivative or a 1, 3, 5-benzene trithiophenol-heptamethine cyanine dye triad derivative; the thiophenol or the 1, 3, 5-benzene trithiophenol is connected with a meso-carbon atom of the heptamethine cyanine dye through a sulfur atom, and the heptamethine cyanine dye is formed by connecting two nitrogen-containing heterocyclic ring units through a conjugated methine chain; the nanoparticles are obtained by dropwise adding a derivative solution into water and then removing an organic solvent. The synthesis method of the thiophenol-cyanine dye derivative is simple and easy to implement, stable nanoparticles can be formed, the tumor targeting property can be improved, the aggregation effect far better than that driven by traditional weak interaction is achieved, synchronous optimization of high tumor accumulation and extremely high heat production efficiency is successfully achieved through self-assembly of nanoparticles, and the thiophenol-cyanine dye derivative has good application prospects. An innovative strategy is provided for the development of a high-performance tumor photo-thermal reagent.

The invention discloses an efficient and simple synthesis method of a dibenzotetrathiafulvalene derivative, which is characterized in that benzene-1, 2-thiophenol or a derivative of benzene-1, 2-thiophenol is subjected to dimerization in a solvent containing acetic acid under a solvothermal reaction condition to obtain the dibenzotetrathiafulvalene or the derivative of dibenzotetrathiafulvalene. The solvothermal reaction conditions are mild, the operation is simple, and the method is suitable for large-scale preparation and environment-friendly. No toxic by-product is generated in the reaction, the reaction product does not need to be purified, the high-purity crystal compound can be obtained, the product efficiency is improved, and the selectivity is guaranteed.

The invention discloses a green light-emitting diode device and a preparation method thereof. FAPbBr3 perovskite nanocrystals are synthesized by a ligand-assisted reprecipitation method, wherein FABr and PbBr2 serve as FA sources, Pb sources, and Br sources, chloroform serves as an antisolvent, and acetonitrile serves as a reaction quencher. The green light-emitting diode device comprises a substrate printed with an anode, a hole transport layer, a hole injection layer, a light-emitting layer, a first electron transport layer, a second electron transport layer, and a cathode, which are arranged in sequence from bottom to top. By adding thiophenol as a new organic ligand to acetonitrile to replace part of the traditional ligand, the surface defects of the material are significantly passivated, thereby improving the photoluminescence quantum yield of the material and the photoelectric performance of the LED prepared from the material. Unlike traditional ligands, thiophenol does not contain a long alkyl chain but has a benzene ring with better conductivity, so the electrical performance of the LED prepared using the thiophenol is also improved. In addition, it can be proved that the introduction of thiophenol does not affect the emission wavelength of the LED.

The present invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing thiosemicarbazone compounds. The method for synthesizing thiosemicarbazone compounds uses (isocyanimino) triphenylphosphine and one of thiophenol substances, thiol substances, and disulfide substances as reactants, and uses methanol or a mixed solution of methanol and water as a solvent for reaction. After separation and purification, thiosemicarbazone compounds are obtained. The synthesis method of the present invention has mild conditions, does not require additional metals and additives, the product is easy to separate and has a high yield, and the reaction is green and efficient.

The invention relates to the technical field of tire rubber manufacturing, and discloses an electric vehicle tire tread rubber composition containing a thiophenol lignin hybrid material and a mixing method of the electric vehicle tire tread rubber composition, and the thiophenol lignin hybrid material is added into the rubber composition. The thiophenol lignin hybrid material is a hydrophobic thiophenol material obtained through reaction modification of lignin and sulfur, can be directly applied to traditional dry-method mixing, effectively improves the dispersity of lignin in rubber, improves the mechanical property and stability of a rubber material, reduces rolling resistance, realizes effective replacement of carbon black, and is simple in process, convenient to operate, convenient, fast and efficient. And large-scale industrial production can be realized more easily.

The invention discloses a hydrophobized thiol-modified silver nanostar paper-based material, a preparation method, and an application thereof, and belongs to the field of perchlorate detection. The method comprises the following steps: first, using NaCl to displace citrate modified on the surface of a silver nanostar sol, and then removing excess chloride ions to obtain the displaced silver nanostar sol; then, using 4-aminothiophenol to perform thiol modification on the displaced silver nanostar sol to obtain the thiol-modified silver nanostar sol; and finally, loading the thiol-modified silver nanostar sol on filter paper by vacuum filtration to obtain a paper-based substrate. The paper-based substrate is then hydrophobized using polydimethylsiloxane to obtain the hydrophobized thiol-modified silver nanostar paper-based material. The method is simple and reliable, and can achieve trace and rapid detection of perchlorate in water by synthesizing an AgNS structure with high plasmon activity, and then performing thiol modification, loading the paper-based substrate, and hydrophobizing the paper-based substrate.

The invention discloses a novel photoinitiator as well as a preparation method and application thereof, a thiophenol group substituted by methyl, ethyl or isopropyl is introduced into a molecular structure of the photoinitiator, so that the absorption wavelength of the photoinitiator is adaptive to a UV-LED light source of 365-405nm, and the problem that the existing photoinitiator is insufficient in matching with the UV-LED light source is solved. The preparation method comprises the following steps: carrying out acylating chlorination on 2, 4, 6-trimethylbenzoyl phenylphosphonic acid through thionyl chloride, condensing the 2, 4, 6-trimethylbenzoyl phenylphosphonic acid and substituted p-thiophenol in an organic solvent, and purifying to obtain a target product, and the preparation process is simple and convenient to operate and suitable for industrial production. The obtained photoinitiator shows good compatibility and efficient curing efficiency in a UV-LED photocuring system, can be widely applied to the fields of printing ink, photocureable coatings, UV adhesives and the like, and has important significance in promoting popularization of a UV-LED curing technology.

The application discloses a metal organic complex with controllable morphology and a preparation method thereof, and belongs to the technical field of metal organic complex preparation. The preparation method of the metal organic complex with controllable morphology comprises the following steps: dissolving cuprous oxide and 4-hydroxythiophenol in anhydrous ethanol to form a mixed solution A; circulating nitrogen into the mixed solution A and performing air extraction and inflation to obtain a mixed solution B; and performing a heating reaction on the mixed solution B under stirring to obtain a reaction liquid capable of controlling the morphology of the metal organic complex; wherein the morphology of the metal organic complex is controlled by controlling the heating reaction time; and the reaction liquid is sequentially filtered, washed and dried to obtain the metal organic complex, wherein the morphology of the metal organic complex is linear or flaky. According to the method, linear or flaky two completely different morphologies can be stably and controllably obtained by only adjusting the heating reaction time, and the flexibility and convenience of morphology control are remarkably improved.

The invention discloses a 2, 4-dimethylthiophenol and triphenylphosphine co-protected silver nanocluster and a preparation method thereof.The center of the silver nanocluster is a sulfur atom, the central sulfur atom is connected with six silver atoms in the form of mu-6 to form a cube framework, and a sulfur-silver conjugated network is constructed; a sulfur atom of the triphenylphosphine ligand is located at the center of a cube surface, and ligand electron cloud is connected with an inner core through an Ag-S bond to form a cross-plane charge transmission path, so that the electron delocalization dimension is further widened; the symmetric framework of the cube and the number of fixed ligands constrain the size of the cluster. The electron-space structure of the silver nanocluster is reconstructed at the atomic scale through a sulfur centralization inner core and multistage ligand connection strategy, the inherent limitation of a metal inner core is broken through, and a new material basis is provided for high-sensitivity sensing, efficient photocatalysis and stable photoelectric devices.

The invention discloses a preparation method of hydrobromic acid vortioxetine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking o-aminothiophenol and Boc2O as initial raw materials, carrying out amino protection to obtain an intermediate 1; reacting the intermediate 1 with 2, 4-dimethyl bromobenzene under an alkaline condition to form a thioether bond, and acidifying to obtain an intermediate 2; carrying out high-temperature cyclization on the intermediate 2 and bis (2-bromoethyl) amine hydrobromide in mesitylene, so as to obtain a crude product of the hydrobromic acid vortioxetine; and recrystallizing the crude product with 95% ethanol to obtain a high-purity final product. The route is simple, only three-step reaction is needed, a noble metal catalyst is not needed in the whole process, and the problem of metal residues is fundamentally avoided; the selected raw materials are easy to obtain, the reaction condition is mild, the operation is simple and convenient, the process is stable, the total yield is good, the product purity is as high as 99.9%, and the method is suitable for large-scale production.

The application discloses an aggregation-induced emission material with high fluorescence quantum yield and large stokes shift, a preparation method and application thereof, and belongs to the technical field of preparation of the aggregation-induced emission material. The preparation method comprises the following steps: obtaining an intermediate by means of Suzuki-Miyaura coupling reaction of an organic boric acid and bromosalicylaldehyde; and adding the intermediate, sodium metabisulfite and aminophenylthiophenol into an organic solvent, and then performing high-temperature reaction to prepare the aggregation-induced emission material. The aggregation-induced emission material is synthesized by means of a two-step method, can be rapidly and mass-produced, and has the advantages of high fluorescence efficiency, large stokes shift, good stability and the like.

The present application relates to the determination of pentachlorothiophenol in rubber, comprising the following steps: (1) pyrolysis gas chromatography mass spectrometry test standard solution; (2) draw standard curve; (3) sample test; (4) sample qualitative judgment; (5) sample quantitative calculation result. The present application optimizes the quantitative method of pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) for detecting the content of pentachlorothiophenol in rubber products, and quickly confirms the content of pentachlorothiophenol in rubber products.

Copolymers comprising recurring units of a phenyl glycidyl ether and alkylene oxides are disclosed. Some of the copolymers comprise a di- or polyfunctional nucleophilic initiator and recurring units of the phenyl glycidyl ether and an alkylene oxide. The di- or polyfunctional nucleophilic initiator is an alcohol, phenol, amine, thiol, thiophenol, sulfinic acid, or deprotonated species thereof. Other copolymers comprise a monofunctional nucleophilic initiator selected from thiols, thiophenols, aralkylated phenols, sulfinic acids, secondary amines, C10-C20 terpene alcohols, and deprotonated species thereof. Pigments dispersions comprising the copolymers are also disclosed. The copolymers meet the growing needs of the industry with their ease of manufacture, diverse structures, and desirable performance attributes for dispersing a wide range of organic and inorganic pigments. Agricultural applications for the copolymers are also disclosed.

This invention discloses a method for preparing co-assembled nanoparticles of thiophenol-heptamethine dye monomer and its triplet derivative, as well as their applications. The co-assembled nanoparticles comprise thiophenol-heptamethine dye monomer and a triplet derivative. The derivative is formed by linking the sulfur atom of thiophenol to the middle carbon atom of heptamethine dye, and the heptamethine dye is formed by two nitrogen-containing heterocyclic units linked by a conjugated methylene chain. The method involves mixing solutions of the two derivatives and adding them dropwise to water, followed by removal of the organic solvent to obtain co-assembled nanoparticles with uniform particle size. This invention significantly enhances the assembly stability of the nanoparticles while successfully retaining the excellent photothermal conversion efficiency of the triplet derivative, overcoming the technical bottleneck of the difficulty in stabilizing high-heat-generating molecules into particles. It achieves synergistic optimization of the assembly stability and photothermal efficiency of photothermal reagents, providing a novel design strategy and technical support for the development of high-performance tumor photothermal therapy drugs.

This invention discloses an internal standard-assisted petal-shaped SERS nanoprobe, its preparation method, and its applications. The internal standard-assisted petal-shaped SERS nanoprobe of this invention is a core-molecule-shell structure gold nanoprobe consisting of a gold nanosphere core, an internal standard modifying molecule, a petal-shaped gold nanoshell, and a recognition molecule, 4-nitrobenzenethiophenol. The internal standard modifying molecule is a Raman signal molecule with nitrile, alkyne, or azide functional groups. This invention uses a Raman signal molecule as an internal standard modifying molecule to modify the gold nanosphere core. The corrected working curve exhibits good reproducibility and small error, improving the reliability of the detection results. Growing a petal-shaped gold nanoshell on the molecular layer of the internal standard modifying molecule enhances the SERS activity both inside and outside the SERS substrate, and the petal-shaped shell increases the surface area of ​​the SERS substrate. Furthermore, the recognition molecule of this invention enables ratiometric Raman detection of hydrogen sulfide, effectively reducing background signal interference and improving detection sensitivity.