192 results about "Hydroxybenzoic acid" patented technology

This invention belongs to the technical field of medicinal chemistry, specifically relating to a novel crystal form of cariprazine, specifically the cariprazine-4-hydroxybenzoic acid-methanol-hemihydrate crystal form and its preparation method. The novel cariprazine-fumaric acid crystal form provided by this invention comprises a basic unit of one molecule of cariprazine, one molecule of 4-hydroxybenzoic acid, one molecule of methanol, and 0.5 molecules of water. Its preparation method is simple to operate, the crystallization process is easy to control, and it has good reproducibility. The formation of a eutectic significantly enhances the solubility of cariprazine, exhibiting strong pharmaceutical value.

The present application provides a reversible thermochromic microcapsule pigment which is easily changed to a colored state from a colorless state by heating at a temperature in a living environment temperature range or a temperature close to a daily life temperature, and is sensitively recovered to the colorless state again. The reversible thermochromic microcapsule pigment of the present application is formed by enclosing a reversible thermochromic composition in a microcapsule, the reversible thermochromic composition comprising (A) an electron-donating colored organic compound, (B) a 4-hydroxybenzoic acid ester compound represented by the following general formula (1) as an electron-accepting compound (in the formula, R represents a linear or branched alkyl group having 12 to 22 carbon atoms), (C) a chain hydrocarbon compound or the like as a reaction medium in which reversible electron transfer reactions based on the above (A) and (B) occur, (D) a linear dibasic acid compound having 3 to 22 carbon atoms, and (E) an aromatic hydrocarbon compound or the like having a melting point of 50°C or higher.

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

The application relates to the technical field of functional films for semiconductor material processing, and discloses a low-residual, heat-resistant and anti-static semiconductor wafer cutting protection film. The protection film comprises a functional adhesive layer arranged on the surface of a base film, and the functional adhesive layer is composed of a synergistically modified polymer matrix, an organic small-molecule interface regulator, a heat-resistant toughening agent, an anti-static auxiliary agent, a residual inhibiting auxiliary agent and a rheological adjusting agent. The synergistically modified polymer matrix is formed by synergistic modification of an acrylate main chain polymer, 2-aminoethyl methacrylate, p-benzene dicarboxaldehyde, tannic acid and an amino-terminated polydimethylsiloxane, and the organic small-molecule interface regulator is 2,5-dihydroxybenzoic acid. The preparation method is simple and controllable, and is suitable for the semiconductor wafer cutting process with high requirements for cleanliness, heat resistance and static control.

The invention discloses a use method of 2, 4-dihydroxybenzoic acid dissolving and recrystallizing equipment, the 2, 4-dihydroxybenzoic acid dissolving and recrystallizing equipment comprises a closed dissolving kettle, a crystallization kettle and a mother liquor storage tank, the closed dissolving kettle, a first separator, a first filtrate storage tank and the crystallization kettle are connected in sequence, and the mother liquor storage tank is connected with a second separator. A discharge port of the crystallization kettle is connected with a feed port of a second separator, a filtrate discharge port of the second separator is connected with a liquid inlet of a second filtrate storage tank, and a liquid outlet of the second filtrate storage tank is communicated with a liquid inlet of the mother liquid storage tank through a third pipeline; the second pipeline between the first separation column and the second pump body is communicated with a liquid outlet of the mother liquid storage tank through a fourth pipeline; the second pipeline between the second pump body and the fourth pipeline is communicated with one end of a backflow pipeline, and the other end of the backflow pipeline is communicated with the first pipeline. The 2, 4-dihydroxy benzoic acid dissolving and recrystallizing equipment disclosed by the invention can be used for preparing 2, 4-dihydroxy benzoic acid with the purity of 99.68%, and the content of metal ions is reduced to 0.15 ppm.

The invention relates to the technical field of coatings, in particular to a graphene modified polyurethane coating with an electromagnetic shielding function. The coating is composed of deionized water, a graphene modified polyurethane emulsion, silver nanoparticles and an auxiliary agent, a synergistic modification system of hydroxylated graphene and p-hydroxybenzoic acid is introduced in a polyurethane prepolymerization stage, an organic-inorganic synergistic network with good interface compatibility is formed, the conductivity and electromagnetic shielding effect of the coating are remarkably improved through a formed compact conductive path, and meanwhile the flexibility and adhesive strength of polyurethane are kept. The coating is compact in structure, high in adhesive force, good in conductive continuity and excellent in electromagnetic shielding effect, and can be widely applied to the field of electromagnetic protection of electronic equipment shells, communication devices and aerospace equipment.

The invention relates to the technical field of biology, in particular to a pine bark polyphenol extract as well as a preparation method and application thereof. According to the present invention, the pine tree bark polyphenol extract is obtained through extraction with an ethanol solution, and the pine tree bark polyphenol extract mainly comprises 2-Hydroxy-4-hydroxybenzoic acid, Pinosylvin, Hispidulin, 3, 5-Dimethoxyphenol, 2, 3, 5, 4 '-Tetrahydroxystilbene, 2-O-beta-D-glucose, Quercetin-3-O-glucose, 6-O-Caffeoyl-D-glucose, Galvantinol, MeIAA and Rhapontigenin, and the pine tree bark polyphenol extract can be used for preparing the pine tree bark polyphenol extract, and can be used for preparing the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract, the pine tree bark polyphenol extract and the preparation method thereof, the pine bark polyphenol extract can be used for effectively relieving LPS (lipopolysaccharide)-induced intestinal barrier injury of weaned piglets by regulating intestinal flora (improving Pediococcus abundance and reducing Alloprevotella abundance) and a tryptophan-AhR pathway under the condition that the addition amount of the pine bark polyphenol extract is lower than 0.05 wt%.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention discloses a high-temperature-resistant liquid crystal polymer substrate for ultrathin flexible display, which belongs to the technical field of flexible display and comprises a modified liquid crystal polymer and a functional additive dispersed in the modified liquid crystal polymer. The modified liquid crystal polymer is prepared by polymerizing a monomer composition, and is specifically prepared from 38 to 42 parts of p-hydroxybenzoic acid, 28 to 30 parts of 4, 4 '-biphenol, 5.6 to 6.0 parts of terephthalic acid, 4.4 to 5.0 parts of 2, 6-naphthalic acid, 2.7 to 3.3 parts of isophthalic acid, 9 to 11 parts of 2, 2-bis (3, 5-difluoro-4-hydroxyphenyl) hexafluoropropane, 4.5 to 5.5 parts of N, N'-dihydroxypyromellitic diamine, 9 to 11 parts of 9, 9-bis [4-(4-methoxycarbonyl phenoxy) phenyl] fluorene and 1, 2-bis (4-(4-methoxycarbonyl phenoxy) phenyl] fluorene. The component A is prepared from 5.5 to 6.5 parts of 1, 4-cyclohexanedimethanol; the functional additive comprises an azobenzene derivative, a hot acid generator and a hydrogen bond enhancer; through the synergistic effect of a specific monomer combination, a functional additive and an optimization process, the technical bottleneck that heat resistance, transparency, dimensional stability and flexibility of an existing material are difficult to consider at the same time is broken through.

The invention belongs to the technical field of solid waste treatment and utilization, and particularly relates to modified manganese slag and application thereof in preparation of a cement material. The modified manganese slag disclosed by the invention is prepared by a method comprising the following steps: uniformly mixing maleic anhydride grafted polyethylene, epoxy group modified manganese slag, epoxy group modified nano alumina fiber and epoxy group modified basalt fiber, and then performing melt extrusion to obtain a polyethylene grafted manganese slag-polybasic fiber compound, and uniformly mixing the polyethylene grafted manganese slag-polybasic fiber compound and 5-chlorosulfonyl-2-hydroxybenzoic acid, and carrying out melt extrusion to obtain the modified manganese slag. The basalt fiber and the nano alumina fiber are combined with the manganese slag through chemical bonds and polyethylene long chains to form a compound, so that the combination stability and dispersion uniformity of the basalt fiber, the alumina fiber and the manganese slag can be improved, and the basalt fiber and the alumina fiber can play an anchoring role in a cement material; the mechanical strength and the low-temperature freezing resistance of the cement material are improved.

The present application belongs to the technical field of daily chemical preparation, and particularly relates to a gynecological gel for inhibiting bacteria, regulating microecological balance and tightening vagina and a preparation method thereof. The gynecological gel comprises the following raw materials in mass fractions: 0.5-1 parts of carbomer, 0.04-0.09 parts of sodium hydroxide, 1-3 parts of collagen, 0.01-0.06 parts of sodium hyaluronate, 0.5-1.5 parts of isomaltooligosaccharide, 2-5 parts of propylene glycol, 0.05-0.3 parts of hydroxybenzoic acid methyl ester, 0.02-0.15 parts of hydroxyphenyl ethyl ester, 0.1-1.5 parts of hydrogenated lecithin, 1-6 parts of 1,3-butanediol, 3-5 parts of glycerol, 0.5-1 part of xanthan gum and 70-90 parts of water. The present application uses buckwheat filtrate to prepare collagen, and the active ingredients in the buckwheat filtrate can penetrate the cell membrane of pathogenic bacteria to play an antibacterial role; the collagen can repair the vaginal mucosa barrier and reduce the adhesion and invasion of pathogenic bacteria; therefore, after being compounded with the raw materials such as carbomer, sodium hydroxide, sodium hyaluronate, isomaltooligosaccharide and propylene glycol, the multiple components can synergistically promote the synthesis and repair of collagen fibers and improve the elasticity of tissues.

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

The invention relates to the technical field of catalysts, in particular to a preparation method of an iron-cobalt oxide and Beta molecular sieve composite catalyst and application of the iron-cobalt oxide and Beta molecular sieve composite catalyst to demethoxylation of lignin derivative vanillic acid. Meanwhile, due to the interaction of iron and cobalt species, the acid site of the catalyst is enhanced, and adsorption and activation of a substrate are facilitated; the iron-cobalt oxide is combined with the Beta molecular sieve, and the reaction activity of demethoxylation is improved through cooperation of metal / zeolite; the Co0 / Fe0. 04Co0. 96O-Beta composite catalyst is used for a vanillic acid demethoxylation catalytic reaction, the reaction is performed for 2 hours under the condition of 0.4 MPa H2 and 0.4 MPa CO2, the substrate conversion rate reaches 96.07%, the p-hydroxybenzoic acid selectivity reaches 86.96%, and the target product yield is 83.54%.

The present invention provides a vasospasm inhibitor and an oral composition for inhibiting vasospasm that can suppress abnormal vasoconstriction (vasospasm). [Solution] A vasospasm inhibitor and an oral composition for inhibiting vasospasm, containing as an active ingredient at least one compound selected from the group consisting of 2,5-dihydroxybenzoic acid, trans-3-caffeoylquinic acid, trans-4-caffeoylquinic acid, trans-5-caffeoylquinic acid, and 2-hydroxybenzoic acid, or a salt thereof.

The invention relates to the technical field of medical crystallization, and particularly discloses benzocain-2, 6-dihydroxy benzoate monohydrate as well as a preparation method and application thereof. The benzocain-2, 6-dihydroxy benzoate monohydrate has the following characteristic diffraction peaks in an X-ray powder diffraction pattern which is determined by adopting rays: the diffraction angle values are 6.28 degrees, 12.48 degrees, 15.12 degrees, 17.40 degrees, 19.44 degrees, 22.92 degrees, 23.88 degrees, 26.46 degrees and 27.76 degrees. According to the invention, benzocaine is taken as an active ingredient, 2, 6-dihydroxybenzoic acid monohydrate is taken as a salt-forming agent, and the formed salt can obviously improve the water solubility, antibacterial property and stability of benzocaine; and the preparation method is simple to operate, low in energy consumption, low in solvent consumption, even free of solvent, good in product reproducibility and beneficial to industrial production.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The application belongs to the field of enzyme engineering and biotechnology, and discloses a 4-hydroxybenzoic acid hydroxylase mutant and application thereof in synthesis of gallic acid or a salt thereof. The 4-hydroxybenzoic acid hydroxylase mutant is obtained through directional evolution modification and high-throughput screening, and has an increased protocatechuate hydroxylase activity by more than 4 times. The 4-hydroxybenzoic acid hydroxylase mutant is expressed by using E. coli, and the obtained recombinant E. coli can efficiently catalyze the conversion of protocatechuate into gallic acid. The 4-hydroxybenzoic acid hydroxylase mutant is expressed in the recombinant E. coli for producing protocatechuate, and the obtained recombinant E. coli can de novo synthesize gallic acid from glucose as a substrate, and the yield reaches 58.65 g / L, and the residual amount of protocatechuate is only 0.33 g / L. The application solves the problem of a large amount of residual protocatechuate in the fermentation process of the existing strains, and can provide an efficient enzyme element for the creation of gallic acid industrial strains.

The application belongs to the technical field of medicines, and specifically discloses an anti-depression m-hydroxybenzoic acid compound and a preparation method and application thereof; the m-hydroxybenzoic acid compound Hyperioxides A-F provided by the application has not been reported; the six compounds have good anti-depression effects, and further research shows that the compounds Hyperioxide A, Hyperioxide D, Hyperioxide E and Hyperioxide F have significant protective effects on SH-SY5Y cells induced by corticosterone, and are superior to positive drugs fluoxetine and Luoyoutei, and can be used for developing drugs for treating depression.

This invention discloses a method for synthesizing potassium 4-methoxysalicylate based on supramolecular-assisted methylation, belonging to the field of organic synthesis technology. The process is based on supramolecular chemistry principles and includes the following steps: (1) Preparation of a macrocyclic host molecule-methylating agent complex loaded with a methylating agent: The macrocyclic host molecule and the methylating agent are reacted at pH 7-9 and 25-40℃ to form a complex solution; (2) One-pot preparation of the target product: 2,4-dihydroxybenzoic acid is salted with potassium hydroxide, potassium carbonate is added, and the above complex solution is added dropwise. A selective methylation reaction is carried out at 55-65℃. After the reaction is complete, post-treatment yields the product. This invention utilizes the molecular recognition function of the macrocyclic host to achieve highly selective methylation of the 4-hydroxyl group under mild conditions. This process has the advantages of simple operation, high safety, low waste, and recyclable host molecules. The yield of potassium 4-methoxysalicylate can reach over 85%, and the purity exceeds 99.0%.

This invention relates to a method for identifying and detecting urinary biomarkers of whole-grain wheat intake. These biomarkers include glycine conjugates of 3,5-dihydroxybenzoic acid, sulfate conjugates of o-aminophenol, sulfate conjugates of 2-acetaminophen, sulfate conjugates of 3,5-dihydroxyphenylvaleric acid, glucuronic acid conjugates of o-aminophenol, or glucuronic acid conjugates of 2-acetaminophen. The invention also relates to a high-throughput screening method for urinary biomarkers of whole-grain wheat intake. A whole-grain wheat dietary intervention experiment was designed, and through comparative analysis of human urinary metabolic profiles, non-targeted metabolomics technology was used to screen for urinary metabolic biomarkers of whole-grain wheat, providing a method for accurately assessing whole-grain wheat intake.

This application relates to a MALDI reactive matrix, 5-methoxy-2-hydroxybenzoyl hydrazine, for the analysis of reducing sugars, belonging to the field of sugar biochemical analysis technology. This application provides the application of 5-methoxy-2-hydroxybenzoyl hydrazine as a MALDI reactive matrix in combination with 2,5-dihydroxybenzoic acid in the analysis of reducing sugars. Specifically, 5-methoxy-2-hydroxybenzoyl hydrazine is the reactive matrix, possessing a hydrazine reactive group that can react with the hemiacetal terminus of reducing sugars. 2,5-dihydroxybenzoic acid acts as a catalyst, significantly promoting the efficient reaction between 5-methoxy-2-hydroxybenzoyl hydrazine and reducing sugars. The 5-methoxy-2-hydroxybenzoyl hydrazine / 2,5-dihydroxybenzoic acid composite matrix provided in this application can form a uniform co-crystallization with reducing sugars, exhibiting good signal reproducibility (RSD < 10%) and good linearity in the range of 0.2~20 pmol / μL (R0). 2 > 0.999).

This invention relates to a polyester polyol, a polyurethane resin, their preparation methods, and applications, belonging to the field of synthetic leather technology. The raw materials for preparing the polyester polyol, by weight percentage, include 7-15% polyethylene glycol, 22-39% p-hydroxybenzoic acid, 31-46% vanillic acid, and 12-24% 1,3-propanediol. The raw materials for preparing the polyurethane resin, by weight percentage, include 4-20% of the above-mentioned polyester polyol, 3-19% aliphatic polycarbonate diol, 1-4% isocyanate A, 1-4% isocyanate B, 1-4% aromatic polyester diol, and 60-80% solvent A. This invention, through formulation design of the polyester polyol and polyurethane resin, produces synthetic leather with high blackness and high gloss, which can maintain this high blackness and high gloss effect for a long time.

The invention discloses high-performance LCP (Liquid Crystal Polymer) resin and a preparation method thereof, and relates to the technical field of LCP resin. According to the preparation method, p-hydroxybenzoic acid, p-tert-butylcatechol and 5-vinyl isophthalic acid are taken as key monomers, LCP base resin with a side chain containing double bonds and tert-butyl is synthesized, then the LCP base resin and alkenyl-terminated polyarylester are subjected to melt extrusion, and the high-performance LCP resin is prepared. According to the present invention, the polyarylester and the alkenyl-terminated polyarylester form the micro-cross-linked structure during the processing, such that the excessive orientation of the molecular chain is effectively inhibited, the anisotropy is reduced, the melt strength and the processability are significantly improved, and the obtained resin has characteristics of high mechanical property and improved toughness, and is especially suitable for preparing the high-performance LCP material.

The invention provides a method for detecting the content of fluticasone propionate cream. The method comprises the following steps: preparing an internal standard substance solution, preparing a test solution, preparing a reference substance solution, detecting and analyzing. According to the method, the cream is dispersed by heating in a water bath, the problem of uneven dissolution of the cream is solved, and the solution is centrifuged and filtered in a low-temperature environment of 6-10 DEG C to remove matrix impurities, so that the treatment efficiency of a cream sample can be improved, and the influence of personnel operation on a detection result can be effectively reduced; the accuracy of a detection result is improved. Besides, heptyl 4-hydroxybenzoate is selected as an internal standard substance, the retention behavior of heptyl 4-hydroxybenzoate is matched with that of fluticasone propionate, the solubility of heptyl 4-hydroxybenzoate in 65% ethanol is consistent, matrix adsorption and extraction errors can be effectively corrected, and the accuracy and reproducibility are remarkably superior to those of an existing method.

A sulfur-modified iron-nitrogen-carbon catalyst and its preparation and application. The present application relates to a preparation method of a series of sulfur-doped iron-nitrogen-carbon catalysts with high catalytic activity obtained by changing the addition amount of thiourea in the catalyst synthesis process and its application. Even under the water quality conditions containing a series of high-concentration inorganic anion humic acid, the catalyst can still achieve high-efficiency degradation of hydroxybenzoic acid. The sulfur atom doping plays a very important role in improving the activity of the main catalytically active site Fe-N4 activated persulfate, forming a catalytic reaction system dominated by singlet oxygen active groups, and realizing selective degradation of organic pollutants with different molecular structures, not only meeting the requirements of high catalytic activity, high stability and high adaptability of the catalyst, but also providing an effective preparation method for improving the catalytic activity of the traditional Fe-N4 structure site, which has good prospects in the application field of degrading organic wastewater containing a large amount of complex matrix.

The application provides a supramolecular glass and a preparation method thereof. The preparation method of the glass comprises the following steps: taking cyclodextrin as a host molecule, taking hydroxybenzoic acid as a guest molecule, mixing the host molecule and the guest molecule, adding a certain amount of water, heating and reacting until a transparent semi-hardened product is obtained; then, the product is hot-pressed and cooled to room temperature to obtain the supramolecular glass; wherein the amount of water added is 5-10 wt% of the mass of the host molecule and the guest molecule. The method can prepare a glass with high transmittance, and the preparation method is simple, raw materials are easy to obtain, the preparation process is non-toxic and harmless, and the method is green and environmentally friendly.

The invention discloses an enhanced halogen-free nylon composite material based on polyamide-6 and a preparation method thereof. According to the composite material, synergistic modified polyamide-6 serves as a matrix, maleic anhydride and 3-aminopropyltriethoxysilane are introduced under the melting or reaction condition to conduct synergistic modification on the polyamide-6, 2, 5-dihydroxybenzoic acid is further added to serve as an organic small molecule function regulating agent, and the composite material is prepared. Meanwhile, the halogen-free flame retardant, the reinforcing filler, the compatilizer, the antioxidant and the processing aid are matched to construct a multi-component synergistic effect system. The composite material can obtain excellent halogen-free flame retardant property under the condition of lower flame retardant dosage, has higher mechanical strength, toughness and processing stability, and is suitable for the fields of electronic and electric appliances, automobile parts and engineering structure materials.

The present invention provides a vasospasm inhibitor and an oral composition for inhibiting vasospasm that can suppress abnormal vasoconstriction (vasospasm). [Solution] A vasospasm inhibitor and an oral composition for inhibiting vasospasm, containing as an active ingredient at least one compound selected from the group consisting of 2,5-dihydroxybenzoic acid, trans-3-caffeoylquinic acid, trans-4-caffeoylquinic acid, trans-5-caffeoylquinic acid, and 2-hydroxybenzoic acid, or a salt thereof.

The invention relates to the technical field of pharmaceutical co-crystals, and particularly discloses a benzocain-3, 5-dihydroxybenzoic acid co-crystal as well as a preparation method and application of the benzocain-3, 5-dihydroxybenzoic acid co-crystal. The benzocain-3, 5-dihydroxy benzoic acid eutectic crystal provided by the invention comprises benzocaine and 3, 5-dihydroxy benzoic acid, and the molar ratio of the benzocaine to the 3, 5-dihydroxy benzoic acid is 1: (0.8-1.2). According to the benzocain-3, 5-dihydroxybenzoic acid eutectic crystal prepared by the invention, the equilibrium solubility, antibacterial property and stability of benzocaine can be effectively improved; the preparation method of the benzocain-3, 5-dihydroxy benzoic acid eutectic crystal provided by the invention is simple in process, easy to control the crystallization process and good in reproducibility, and has relatively good economical efficiency and industrial production value.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.