30 results about "Glutaric acid" patented technology

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

This invention provides a continuous preparation method for dimethyl 2-methylglutarate, carried out in a first microchannel reactor and a second microchannel reactor connected in series. The method includes: feeding 2-methylglutaronitrile and sulfuric acid solution into the first microchannel reactor for hydrolysis; and contacting them with methanol in the second microchannel reactor for esterification. The esterified material is then subjected to phase separation to obtain dimethyl 2-methylglutarate. The mass ratio of 2-methylglutaronitrile to sulfuric acid solution is 1:(5~20). The controlled temperature of the first microchannel reactor is 80~120℃; the controlled temperature of the second microchannel reactor is 65~105℃, and the controlled temperature of the second microchannel reactor is not higher than that of the first microchannel reactor; the mass ratio of 2-methylglutaronitrile to methanol is 1:(1~6). Through the synergistic operation of the microchannel reactor and multiple control parameters, the eutectic precipitation of intermediate products with ammonium sulfate can be avoided, clogging can be prevented, and efficient, high-yield continuous preparation can be achieved.

The application provides application of glutaroyl-CoA dehydrogenase in inducing ferroptosis of liver cancer cells, and belongs to the technical field of biotechnology.The application provides application of glutaroyl-CoA dehydrogenase (GCDH) in preparing products for evaluating risk of liver cancer and evaluating prognosis risk of liver cancer, and the tumor stage and T grade can be estimated by detecting the expression amount of GCDH, and the survival effect of liver cancer patients is evaluated.The application provides application of the overexpression reagent of GCDH in preparing products for inhibiting proliferation of liver cancer cells and inducing ferroptosis of liver cancer cells, and the ferroptosis of liver cancer cells is promoted by overexpressing GCDH in cells, and the colony formation ability of liver cancer cells is reduced.Further, the application provides application of the overexpression reagent of GCDH combined with a CA9 inhibitor in preparing products for inhibiting proliferation of liver cancer cells.

The invention relates to the technical field of tin alloy solder, and discloses a preformed soldering lug with high welding strength, which comprises a soldering flux layer and a soldering lug main body, the soldering flux layer comprises esterified rosin, methyl ester, succinic acid, glutaric acid, cyclohexylamine hydrochloride and isopropanol; the soldering lug main body comprises tin, antimony, silver, bismuth, copper and nickel; by adding silver, bismuth, copper, nickel and metal elements in the alloy into the soldering lug, the mechanical strength of the solder alloy can be improved, compared with common tin-copper alloy, the mechanical strength of the soldering lug is greatly improved, the soldering flux is high in activity but low in corrosivity, stable high-mechanical-strength intermediate layer alloy is formed, and the soldering flux can be applied to the field of soldering. The welding strength and the tensile strength are more excellent, the soldering flux layer and the soldering lug main body have the synergistic effect, so that a welded part has high tensile property after being welded, and the mechanical strength of the solder alloy can be improved by adding silver, bismuth, copper and nickel in the alloy into the soldering lug and metal elements.

The application discloses genetically engineered bacteria for producing alpha-ketoglutaric acid and application. The genetically engineered bacteria are obtained by weakening the expression of alpha-ketoglutaric acid dehydrogenase gene odhA, weakening the expression of glutamate transporter protein gene cg1434, weakening the expression of glutamate synthase key subunit gene gltB, weakening the expression of lactic acid dehydrogenase gene ldh, weakening the expression of glutamate dehydrogenase gene gdh, weakening the expression of serine / threonine protein kinase gene pknG, enhancing the expression of pyruvate carboxylase gene pyc, introducing and expressing glutamate oxidase gene lgox at the site of lactic acid dehydrogenase ldh gene, and enhancing the expression of strong catalase gene katA on the basis of a Corynebacterium glutamicum starting strain. The genetically engineered bacteria can efficiently produce alpha-ketoglutaric acid under the condition of limited ammonia culture, and have a good application prospect.

This invention discloses a high-temperature resistant nylon resin and its synthesis method. The high-temperature resistant nylon resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, toluene diisocyanate, organic copper chrome black, acrylate copolymer, and a high-temperature antioxidant. This high-temperature resistant nylon resin possesses excellent mechanical properties, flame retardant properties, and laser direct forming properties, and can be widely used in communication fields requiring flame retardancy and laser direct forming capabilities.

This invention discloses a culture medium and process for alleviating ammonium accumulation in cells. The concentrations of the substances added to the culture medium are as follows: 2 g / L glutamate, 0 g / L glutamine, 2 g / L aspartic acid, 2 g / L asparagine, 1 g / L serine, 1 g / L pyruvate, 0.5 g / L α-ketoglutarate, 0.5 g / L oxaloacetic acid, 0.5 g / L proline, 0 g / L glucose, 8 g / L galactose, and 0.1% glycerol. Compared with the prior art, the advantages of this application are: this method mainly achieves the purpose of maintaining cell viability and reducing the cell metabolic byproduct ammonium ions by adjusting the proportion of substances related to cell metabolic pathways and adding additional cell protectants; using the optimized culture medium of this invention, the cell viability can be increased from 42.38% to 95.21% and the ammonium ion concentration can be reduced from 6.308 mM to 0.914 mM by day 7.

The application belongs to the technical field of plant growth promoters, and particularly relates to application of choline glutaric acid in improving yield and quality of corns. A structural formula of the choline glutaric acid is shown in the figure. The choline glutaric acid is used as a growth regulator, which is helpful to improve the yield of corns, increase the protein content of grains and improve the quality.

The present application relates to a kind of low cost, high hardness epoxy resin for powder coating, which is obtained by reaction of alkali lignin, ethylene glycol monobutyl ether, resorcinol, 3-ethyl-3-methyl glutaric acid, epichlorohydrin, sodium hydroxide, bisphenol A and other raw materials. The present application not only obtains high hardness, excellent comprehensive performance pure epoxy powder coating epoxy resin product, but also provides an industrialization scheme for the comprehensive application of alkali lignin, with better market prospect and application value.

The application belongs to the technical field of chemical industry, and particularly relates to a method for oxidizing cyclopentanone, which comprises the following steps: contacting an oxygen-containing gas with cyclopentanone in the presence of a solvent and a catalyst; and the catalyst contains a zirconium salt. By using the catalyst containing the zirconium salt, the conversion rate of the raw material cyclopentanone and the selectivity of the product glutaric acid in the method for preparing glutaric acid by oxidizing cyclopentanone are improved, the occurrence of a side reaction is reduced, the burden of separating impurities in a synthetic liquid is reduced, and a good technical effect is achieved.

This invention discloses a block-shaped piroxicam crystal and its direct compression formulation method, relating to the field of pharmaceutical formulation technology. The block-shaped piroxicam crystal is prepared according to the following steps: crude piroxicam is dissolved in a solvent, an organic acid and polyvinylpyrrolidone are added, the mixture is cooled and crystallized, and then filtered, washed, and dried to obtain block-shaped piroxicam crystals. The solvent is acetonitrile or ethyl acetate; the organic acid is glutaric acid or citric acid. The active pharmaceutical ingredient powder prepared by this invention has an angle of repose ≤35°, good flowability, which ensures smooth material transportation, mixing, and tableting processes, resulting in small tablet weight differences and high content uniformity. The finished tablet has a hardness ≥90 kgf, high mechanical strength, and a friability ≤0.02%, exhibiting extremely strong wear and breakage resistance, making it less prone to damage during production, packaging, and transportation. The 15-minute dissolution rate ≥50% balances formability and dissolution, facilitating rapid drug release and improving in vivo bioavailability.

This invention discloses a high-temperature resistant polyamide resin and its synthesis method. The high-temperature resistant polyamide resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, 2,2'-(1,3-phenylene)-dioxazoline, organic carbon nanotubes, benzoic acid, and a high-temperature resistant antioxidant. This high-temperature resistant polyamide resin possesses excellent mechanical properties, flame retardant properties, and electromagnetic shielding properties, and can be widely used in communication devices requiring flame retardancy and electromagnetic shielding.

This invention belongs to the field of bioengineering and relates to glutamate oxidase mutants and their application in the biotransformation of α-ketoglutarate. The glutamate oxidase is derived from *Streptomyces molybdenum*, and a series of mutants were obtained through saturation mutation of its 536th amino acid residue. Among them, mutant C536E exhibits significantly enhanced enzyme activity. After expression, induction, and purification, the specific enzyme activity of the mutant is 2.06 U / mg, which is approximately 56% higher than that of wild-type glutamate oxidase. This invention also provides a method for constructing the glutamate oxidase mutant and its application in the preparation of α-ketoglutarate. Compared with existing technologies, the mutants provided by this invention have higher catalytic efficiency and show good application potential in the biotransformation of α-ketoglutarate.

The present application belongs to the field of biotechnology, and particularly relates to a kind of production alpha-ketoglutaric acid recombinant escherichia coli engineering strain and its construction method and application.The present application engineering strain A09 can realize high-efficiency catalysis to high-concentration L-glutamic acid sodium without adding any membrane breaker such as Triton X-100.Under the condition of high-intensity catalysis for 6 hours, the cell membrane structure of the bacterial cell is kept intact without obvious damage.This characteristic completely eliminates the problems such as cell toxicity, product purification complexity, cost increase and process safety reduction caused by the use of surfactant in traditional methods, realizes the perfect unity of "cell integrity" and "high catalytic efficiency", and provides an unprecedented technical solution for the large-scale, industrialized and low-cost production of alpha-ketoglutaric acid.

The application discloses a continuous hydrolysis and extraction purification integrated process of 3-isobutyl glutaric acid, and relates to the technical field of 3-isobutyl glutaric acid. A micro-channel hydrolysis reaction liquid is generated; a high-dispersion acidification mixed liquid is obtained; a high gravity continuous mass transfer and liquid-liquid separation are carried out by using a high-speed rotating centrifugal field, a primary organic extraction phase rich in a target product is extracted; liquid-liquid complex washing is carried out under pulse oscillation, and a purified extraction phase is obtained; organic extraction solvent is gasified and stripped, and a supersaturated liquid material without solvent residue is collected at the bottom; under a multi-stage programmed cooling gradient, nucleation and crystal growth are induced, and a high-purity 3-isobutyl glutaric acid product is extracted after online solid-liquid separation. The application significantly improves the generation quality of a target intermediate and the robustness of a reaction system.

The present invention discloses an anti-aging composition synergistically enhancing mitochondrial function with AKG and PQQ, belonging to the technical field of anti-aging. The composition comprises AKG, PQQ disodium salt, Agaricus bisporus extract, and a single excipient. AKG, in anhydrous crystal form as 2-oxoglutaric acid, directly participates in mitochondrial energy metabolism and provides core substrate support. PQQ disodium salt promotes mitochondrial biogenesis, ensuring structural renewal and maintaining mitochondrial activity. The β-glucan and ergothioneine naturally contained in the Agaricus bisporus extract further support the normal physiological state of mitochondria through synergistic effects. The single excipient is only physically mixed with the active ingredients, reducing interference caused by excipient interactions and ensuring that the efficacy of each active component is fully exerted.

This invention discloses an anti-aging composition that synergistically enhances mitochondrial function using AKG-PQQ, relating to the field of anti-aging technology. The composition comprises AKG, disodium PQQ, button mushroom extract, and excipients. By combining AKG, disodium PQQ, button mushroom extract, and a single excipient, AKG, as 2-oxoglutarate, directly participates in mitochondrial energy metabolism in anhydrous crystalline form, providing core substrate support for mitochondrial function. Disodium PQQ promotes mitochondrial regeneration, ensuring mitochondrial structural renewal and physiological activity. The naturally occurring β-glucan and ergothioneine in the button mushroom extract form a synergistic effect, maintaining the normal physiological state of mitochondria from multiple dimensions. The single excipient only physically mixes with the active ingredients, avoiding interference from interactions between multiple excipients and ensuring the full effectiveness of each active ingredient.

The present application belongs to the field of gene drug delivery, and particularly relates to a kind of lipid compound with glutaric acid skeleton and lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation based thereon.The compound with the structure of formula (I) of the present application can be prepared into lipid carrier alone or together with other lipid compounds.The lipid carrier has high encapsulation efficiency for nucleic acid drugs, which helps to improve the delivery efficiency of nucleic acid drugs in vivo;Multiple biodegradable functional groups are contained, so that the lipid metabolism is fast, and the biological safety is high.Moreover, the lipid carrier can also deliver nucleic acid drugs to organs that need to be enriched, and has good application prospect.

The present application belongs to the solder paste material field of surface assembly technology, and relates to a low-temperature solder paste and a preparation method thereof. The low-temperature solder paste contains a tin-bismuth-based alloy powder and a soldering paste. The soldering paste contains rosin, an active agent, a thixotropic agent, a surfactant, a corrosion inhibitor and an organic solvent. The active agent is a composite of an organic amine and an organic acid. The organic amine is at least one selected from ethylenediamine, monoethanolamine, triethanolamine and ethylamine. The organic acid is at least one selected from 2-pyridine carboxylic acid, oxalic acid, succinic acid, glutaric acid, malonic acid, phthalic acid and dodecanedioic acid. The boiling point of the organic solvent is 190-280 DEG C. The solder paste provided by the present application not only has low-temperature property and is suitable for applications with more low-temperature welding requirements, solves the problem that the medium and high-temperature solder paste is not widely used, but also has the characteristics of less solder beads after welding and low residue.

The present application relates to the technical field of nylon film material, in particular to a preparation method and application of a slow-crystallization high-transparency MXD6 copolymer nylon biaxial stretching film, wherein the preparation method comprises the following steps: first, reacting adipic acid, a binary acid containing an ether bond and m-xylylenediamine in deionized water to generate an MXD6 salt, then copolymerizing the MXD6 copolymer salt to obtain an MXD6 polymer, and adding perfluoroglutaric acid in the copolymerization process; after the reaction is completed, the copolymer MXD6 granules are obtained through extrusion and granulation, and the MXD6 copolymer nylon biaxial stretching film is obtained through biaxial stretching. The MXD6 copolymer nylon biaxial stretching film prepared by the present application has the characteristics of slow crystallization and high transparency.

The application discloses a kind of green enzymatic polycondensation synthesis polyamide 6,5 method, with dimethyl glutarate and 1,6-hexanediamine as raw material, using Novozym435 immobilized lipase as biological catalyst, by direct enzymatic polycondensation reaction preparation biobased polyamide 6,5.The method uses toluene as reaction medium, combined with vacuum by-product, molecular sieve water absorption balance control strategy, realizes the green efficient synthesis of polyamide 6,5, product has excellent thermal stability (melting point 221 DEG C, maximum decomposition temperature 434 DEG C), suitable for melt spinning and other industrial processes, compared with traditional chemical synthesis method, greatly reduce energy consumption, reduce the use of toxic chemicals, provide a new way for the green manufacturing of polyamide.

To provide a method for producing modified wood material with high dimensional stability. [Solution] A method for producing modified wood material, comprising: 1) impregnating an untreated wood material with at least one acid selected from citric acid, malic acid, and glutaric acid, and glycerin to obtain a drug-impregnated wood material; and 2) heating the drug-impregnated wood material obtained in step 1.

This invention relates to the field of asphalt mixtures and discloses a cold-mix asphalt mixture and its preparation method. The cold-mix asphalt mixture comprises: epoxy cold-mix asphalt, coarse aggregate, fine aggregate, mineral powder, and modified lignin fiber; the epoxy cold-mix asphalt comprises: base asphalt, diluent, modified epoxy resin, curing agent, SBR emulsion, and silane coupling agent; the modified epoxy resin is prepared using modified carboxyl-terminated low-polyester epoxy resin E44; the modified carboxyl-terminated low-polyester is prepared by replacing cyanuric chloride with pentaerythritol phosphate and then further substituting it with diethylene glycol to prepare a hydroxyl-terminated modified intermediate, which is then polyesterified by reacting glutaric acid with the hydroxyl-terminated modified intermediate; the modified lignin fiber is prepared by reacting lignin fiber, 2,2,6,6-tetramethylpiperidineamine, and formaldehyde through a Mannich reaction. The asphalt mixture prepared by this invention has good high and low temperature resistance, as well as excellent UV aging resistance and flame retardant effect.

The application provides an AKG-containing anti-aging functional food raw material with improved metabolic absorption rate, which is composed of the following components in parts by weight: diketopiperazine (AKG) 10-30 parts, black pepper extract 1-5 parts, turmeric 5-15 parts, and glutathione 8-20 parts; wherein the content of piperine in the black pepper extract is not less than 95%; and the glutathione is reduced glutathione with a purity of not less than 98.0%. The application takes AKG as a core synergistic absorption carrier, fully utilizes its inherent properties of regulating intestinal microenvironment, promoting intestinal mucosal repair, and activating absorption-related signal pathways, and forms a closed-loop synergy with the metabolic enzyme inhibition of black pepper extract, the intestinal anti-inflammatory effect of turmeric extract, and the antioxidant protection effect of glutathione, so as to crack the oral absorption barrier of the three core functional components from multiple dimensions and improve the metabolic absorption rate.

An aqueous suspension or colloid composition comprising dimethyl glutarate, a further dialkyl ester which is not a sugar ester or dimethyl glutarate, a glycoside surfactant, an essential oil, and a su

This invention discloses a biomarker combination for glioma risk screening or auxiliary diagnosis and its application. The biomarker combination comprises creatine, lactate, succinic acid, N,N-dimethylglycine, 2-oxoglutarate, acetic acid, and glutamate. Based on the biomarker combination provided by this invention, a clinical diagnostic model for assessing glioma risk can be constructed using algorithms such as multivariate logistic regression. The constructed clinical diagnostic model has high sensitivity and specificity, and can quickly and accurately assess the glioma risk of subjects, making it suitable for early screening and auxiliary diagnosis of adult gliomas.

The object of the present invention concerns a hair restructuring association comprising or alternatively consisting of: (a) a quaternary ammonium salt of formula (I) and (b) at least one sulpho-derivative of vegetable fatty acids, wherein R5, R6 are independently chosen between hydrogen and a radical R0, R0 consists of the following structure of formula (II), R1 is chosen from the group consisting of: hydrogen, methyl, isopropyl, sec-butyl, isobutyl, ethylenemethylthio, benzyl, para-hydroxybenzyl and 3-methylene-1H-indole, R2, R3, R4 are independently chosen from the group consisting of: methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, mX− is chosen from the group consisting of: formic acid, acetic acid, unsaturated monocarboxylic acids, adipic acid, aldaric acid, oxalic acid, phthalic acid, azelaic acid, sebacic acid, malonic acid, succinic acid, tartaric acid, glutaric acid, pimelic acid, maleic acid, malic acid, fumaric acid and suberic acid, isocitric acid, citric acid, fatty acids, acidic amino acids, keto acids and aromatic carboxylic acids, m is an integer number comprised between 1 and 22, n is comprised between 2 and 20.