749 results about "Glutaric acid" patented technology

This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.

An environmentally-friendly cleaning composition for industrial and consumer applications comprising (a) a blend of dibasic esters, (b) one or more surfactants (c) and, optionally, (d) water or a solvent. The dibasic esters are be derived from a blend of adipic, glutaric, and succinic diacids, and, in one particular embodiment, the blend comprises dialkyl adipate, dialkyl methylglutarate and dialkyl ethylsuccinate, wherein the alkyl groups individually comprise a C₁-C₁₂ hydrocarbon group. The one or more surfactants are typically chosen from alcohol alkoxylate, an alkyl phenol ethoxylate, a terpene, a terpene alkoxylate or any derivates thereof. Optionally, additional components or additives including delaminates such as pinene and d-limonene, fragrances, whiteners, stabilizers, thickeners and the like can be added to the composition. The industrial or consumer application selected from the group consisting of a graffiti cleaner, a painted-substrate cleaner, an ink cleaner, a metal substrate cleaner, a plastic substrate cleaner, an environmentally friendly cleaner, a stain-spot cleaner, an industrial hand cleaner, a resin cleaner, a tar resin cleaner, a textile cleaner, a paint stripper and any combination thereof.

alpha-keto acids and certain precursors and derivatives thereof, particularly those selected from the group which consists of glyoxylic acid, 2-oxo-propanoic acid, 2-oxo-butanoic acid, 3-methyl-2-oxo butanoic acid, 3-methyl-2-oxo pentanoic acid, 4-methyl-2-oxo pentanoic acid, 3-hydroxy-2-oxo-propanoic acid, oxalacetic acid, 2-oxo-glutaric acid, 2-oxo-3-phenyl-propanoic acid, 3-(4-hydroxy-phenyl)-2-oxo-propanoic acid, 2-oxo-1H-indole-3-propanoic acid, 2-oxo-1H-imidazole-4-propanoic acid, 4-methylthio-2-oxo-butanoic acid, 3-mercapto-2-oxo-propanoic acid, 3-hydroxy-2-oxo-butanoic acid, 6-amino-2-oxo-hexanoic acid and 5-guanido-2-oxo-pentanoic acid, and precursors and derivatives thereof that are capable of being formed from or releasing said acids in the use medium, are useful as flavouring ingredients. Such ingredients are useful for preparing flavouring compositions and a wide variety of flavoured foodstuffs to which they impart greater creaminess and bulkiness so that they have heightened effect in the mouth and generally an enhanced mouthfeel. They are also useful for enhancing the sweetness of foods sweetened with natural or artificial sweeteners, and giving it a more natural character.

The invention relates to acid solution used for processing the magnesium alloy surface. The acid solution is water solution which contains acids, inhibitor and wetting agent, wherein, the acids are first acids or mixture of first acids and second acids; the first acids are selected from one type or a plurality of types among citric acids, oxalic acids, tartaric acids, methanoic acids, acetic acids, metacetonic acids, butyric acids, glutaric acids, phenylformic acids, benzene dicarboxylic acids, lactic acids, glycolic acids, glyoxylic acids and amino acids; and the second acids are hydrochloric acids and/or nitric acids. By adoption of the acid solution, the magnesium alloy surface can be fully activated; the membranous layer of a converting film which is formed on the magnesium alloy surface after chemical conversion process is compact, has erosion resistance and good binding force with a paint film. Moreover, the method is a environment-friendly method for processing the magnesium alloy surface.

The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).

The invention discloses scaling powder for no-clean lead-free low-silver welding paste. The scaling powder comprises, by weight percentage, 3-13% of active agent, 0.2-1.5% of surface active agent, 0.2-3.0% of emulgator, 3.0-10.0% of thixotropic agent, 3-8% of film-forming agent, 0.1-1% of antioxidant, 0.1-0.5% of corrosion inhibitor and the rest of solvent. The active agent is composed of four or five components in succinic acid, oxalic acid, salicylic acid, glutaric acid, citric acid, adipic acid, lactic acid, benzoic acid, malic acid and triethanolamine. The scaling powder for the no-clean lead-free low silver welding paste does not contain halogen, the corrosion to a circuit board is greatly lowered, the printing quality of the welding paste is good without bridging or turned-down edges, a welding point is good in forming after returning, the brazing connecting defect is greatly lowered, the residue is small without solder balls, the cleaning is not needed, the welding paste is directly used for assembling, the Sn-0.45 Ag-0.68 Cu or Sn-0.3 Ag-0.7 Cu low silver welding paste manufactured by using the scaling powder does not contain the halogen and rosin, the organic chemistry smoke is small, and the pollution to the environment is small.

There is provided an aqueous dispersion for CMP with an excellent balance between chemical etching and mechanical polishing performance. The aqueous dispersion for CMP of the invention is characterized by comprising an abrasive, water and a heteropolyacid. Another aqueous dispersion for CMP according to the invention is characterized by comprising an abrasive, water, a heteropolyacid and an organic acid. Yet another aqueous dispersion for CMP according to the invention is characterized by comprising colloidal silica with a primary particle size of 5-100 nm, water and a heteropolyacid. Preferred for the heteropolyacid is at least one type selected from among silicomolybdic acid, phosphorotungstic acid, silicotungstic acid, phosphoromolybdic acid and silicotungstomolybdic acid. Preferred for the organic acid is at least one selected from among oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, phthalic acid, malic acid, tartaric acid and citric acid.

Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative therof; or a diamine derivative. The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.

The invention discloses a multifunctional nutrient ecological dense agent, and preparation and application methods thereof. A formula of the multifunctional nutrient ecological dense agent comprises a solution (A) and a solution (B), wherein the solution (A) is an EM compound probiotic fermentation solution; the solution (B) consists of an organic nutrition adsorbed and complexed chelation carrier and a combined inducer; the EM compound probiotic fermentation solution is prepared by fermentation, activation and expanding propagation of an EM solid bacterial agent; the organic nutrition adsorbed and complexed chelation carrier is a concentrated molasses fermentation solution; active components of the combined inducer are selected from a group consisting of photosynthetic induction factors, tetramethyl glutaric acid, RE nitrate acid rare earth for agricultural use, activator protein, chitosan oligosaccharide, salicylic acid, S-abscisic acid, trehalose, a rooting agent, uniconazole and forchlorfenuron; the solution (A) and the solution (B) are separately stored, and are mixed for preparation before being used. The multifunctional nutrient ecological dense agent is applicable to horticultural crops in greenhouses and large lands, and can be used with ecological cultivation soil in a cooperating manner for high-quality ecological cultivation; by virtue of various application modes such as seed soaking, dripping and spraying, multiple targets of supplying organic nutrition, regulating and inducing resistance to disease and pest, and performing adversity protection are achieved.

Diet cola beverage and other beverage products and methods for making the same are disclosed. The diet cola beverages comprise water, at least one natural, potent, non-nutritive sweetener, at least one natural, low potency, low calorie sweetener, an acidulant comprising at least one of lactic, citric, tartaric, malic, fumaric, cinnamic, maleic, adipic, glutaric, and succinic acids, a caramel colorant, and cola flavor.

The invention discloses a ferric-carbon biologic particle and a preparation method and application thereof. The preparation method of the ferric-carbon biologic particle comprises the following steps: 1) drying, smashing, pyrolyzing, grinding, sieving and washing forestry and agricultural residues to obtain charcoal; 2) soaking the charcoal in a NaOH solution to perform surface activation treatment; 3) sequentially utilizing a polyethyleneimine/ethanol solution and a glutaric acid solution to treat the charcoal with the surface activated to obtain a charcoal particle with amino grafted on the surface, 4) dispersing a soluble molysite solution or a ferrite solution into absolute ethyl alcohol, adding the charcoal particle and a NaBH4 solution, loading nanometer zero-valent iron generated in reaction on the charcoal particle to obtain the ferric-carbon biologic particle. The ferric-carbon biologic particle is good in dispersibility, high in load rate of the nanometer zero-valent iron, good in soil remediation effect, stable in effect, simple in preparation technology, low in energy consumption, low in cost, economical, practical and suitable for being widely used as a remediation material of soil which is polluted by heavy metal.

The present invention relates to a regenerated cellulose fiber which contains a hydrophobic substance selected from the group consisting of alkyl ketene dimers, alkenyl ketene dimers, alkyl succinic anhydrides, alkenyl succinic anhydrides, alkyl glutaric acid anhydrides, alkenyl glutaric acid anhydrides, alkyl isocyanates, alkenyl isocyanates, fatty acid anhydrides as well as mixtures thereof incorporated in the cellulose matrix.

A high concentration, aqueous liquid surfactant composition is disclosed, comprising at least one amphoteric or anionic surfactant and a liquid-stabilizing amount of at least one liquid-stabilizing agent. The liquid-stabilizing agent is a succinic acid derivative, glutaric acid derivative or a combination thereof. The composition is pourable and pumpable at ambient room temperature.

The present invention provides a process for preparing supported zinc dicarboxylate catalysts with high activity for the copolymerization of carbon dioxide and epoxides by supporting zinc dicarboxylate on silica support. The zinc dicarboxylate may be synthesized from zinc oxide and dicarboxylic acid such as succinic acid, glutaric acid, adipic acid, pimelic acid and suberic acid. The silica support can be selected from the group consisting of aerosil, silica gel for chromatography or reagent grade silicon dioxide. The supporting process is performed in a planetary ball grinder under vacuum.

The invention discloses a flue gas desulfurization synergist which comprises the following components in percent by weight: 30-80 percent of adipic acid or glutaric acid, 5-30 percent of one of sodium chloride, sodium sulfate, and magnesium sulfate, and 1-50 percent of dioctyl sulfosuccinate sodium salt. A using method of the flue gas desulfurization synergist is characterized by comprising the steps of: firstly, preparing lime into limestone slurry of 50-300PPm, adding 300-1000mg/L of gas desulfurization synergist in the limestone slurry, mechanically stirring uniformly, and then pumping the limestone slurry added with the gas desulfurization synergist into a desulfuration reaction tower by using a limestone slurry pump. By using the gas desulfuration synergist, the desulfuration efficiency is improved by 5-15 percent, the consumption of limestone is reduced, the scale formation and the blockage of equipment are reduced, and the operation electric energy is saved.

The invention relates to an edible fungus dreg biological organic fertilizer, which mainly comprises the following raw materials in percentage by weight: 75 to 80 percent of edible fungus dreg, 8 to 10 percent of urea, 5 to 8 percent of monoammonium phosphate, 4 to 6 percent of potassium sulfate, 1 to 1.5 percent of microbial bacteria and 0.2 to 0.3 percent of regulator, wherein the regulator is a mixture consisting of tetramethyl glutaric aciduria, diethyl aminoethyl hexanote (DA-6) and 5-nitroguaiacol sodium. The organic fertilizer is used for agricultural production, has effects of improving soil, improving soil fertility, reducing fertilizer loss, improving fertilizer utilization rate and improving crop yield and quality, and is an irreplaceable novel fertilizer product.

The invention relates to the field of pharmaceutical preparations, in particular to a timing pulsed release micro-pill of a zolpidem salt, which is characterized in that the center of the micro-pill is a blank pill core, an external time-lag layer is coated by low-permeability acrylic resin containing quaternary ammonium salt radicals, and a medicament layer and an organic acid layer are arranged between the blank pill core and the time-lag layer, wherein the organic acid layer contains a mixture of two organic acids, and the mixture of the two organic acids is prepared by mixing one of succinic acid, glutaric acid and adipic acid, and one of citric acid, malic acid and tartaric acid. Combining with sleep characteristics of early awakening crowds, the prepared micro-pill has certain release time lag and releases quickly after a period of time lag so that a patient obtains effective blood concentration on the point of awakening so as to prolong the sleep time of the patient.

The invention relates to a method for producing alpha-ketoglutaric acid by virtue of an enzymic method. The method comprises the following steps: respectively synthesizing a glr gene and a daao gene and constructing expression vectors pET24a-glr and pET24a-daao; after double digestion of the expression vectors pET24a-glr and pET24a-daao respectively, connecting the expression vectors pET24a-glr and pET24a-daao to construct a double expression vector pET24a-glr-daao and transforming the double expression vector to escherichia coli to prepare a genetically engineered bacterium which simultaneously expresses glutamate racemase and D-amino acid oxidase; adding a wet thallus of the genetically engineered bacterium into water in a fermentation tank, then adding L-glutamic acid and catalase, and finally adjusting the pH by virtue of sodium hydroxide to prepare a reaction system for reaction; separating and purifying alpha-ketoglutaric acid converted in the reaction system after reaction. The method provided by the invention is low in cost, high in conversion rate (over 84%) and product concentration, and suitable for industrial application.

Dry dipercarboxylic acid material and methods of using dry dipercarboxylic acid particulates to form novel sterilizing solutions or liquid chemical germicides. The dipercarboxylic acids or organic diperoxygen compounds can be synthesized and isolated as solid powders with an extended shelf life. The powders are also soluble in water for quickly preparing liquid disinfectant solutions, whenever and wherever desired, from a potable water source. The dry dipercarboxylic acid materials are selected from diperglutaric acid, diperadipic acid, diperpimelic acid, dipersuberic acid, and diperazelaic acid. Upon dissolution into water, these compounds have demonstrated the ability to inactivate high numbers of spores, including sterilization of medical equipment in 10 minutes at room temperature.

The present invention provides a new binary organic acid production strain, preparation and applications thereof, particular a genetically modified engineering strain for binary organic acid synthesis. According to the present invention, an exogenous binary organic acid synthesis positive regulation gene is introduced into the engineering strain, and/or a binary organic acid synthesis negative regulation gene is down-regulated; compared to the starting strain, the binary organic acid production capacity of the engineering strain is significantly improved, wherein the binary organic acid comprises malic acid, succinic acid, fumaric acid, oxaloacetic acid, glutaric acid, and adipic acid; and the experiment results prove that the genetically modified engineering strain being subjected to the up-regulation of one or a plurality of the positive regulation genes and/or the down-regulation of one or a plurality of the positive regulation genes can resist the high temperature, effectively utilizes monosaccharides, polysaccharides, glycan or mixed saccharides, and particularly utilize the cheap carbon source (such as cellulose and the like) to synthesize the binary organic acid in the high-yield manner.

The invention provides a method for preparing and synthesizing a statin medicinal intermediate, namely, an (R)-3-hydroxy-glutaric acid ethyl ester or a hydroxy substituted derivative of the (R)-3-hydroxy-glutaric acid ethyl ester with high optical activity by performing chiral separation on a racemic 4-cyano-group-3-hydroxy butyric acid ethyl ester or a hydroxy substituted derivative of the 4-cyano-group-3-hydroxy butyric acid ethyl ester and a strain. The method comprises the following steps: performing a conversion reaction in a reaction system in which a compound shown in a formula (11) is used as a substrate and an enzyme obtained by fermenting and culturing rhodococcus erythropolis CCTCC No:M 209244 or CCTCC No:M 209194 is used as a catalyst at the temperature of between 10 and 50 DEG C; and after the reaction, separating and purifying reaction liquid to obtain the compound shown in formula (I). The method realizes obtaining the (R)-3-hydroxy-glutaric acid ethyl ester or the hydroxy substituted derivative of the (R)-3-hydroxy-glutaric acid ethyl ester with high optical activity by catalyzing and hydrolyzing the racemic 4-cyano-group-3-hydroxy butyric acid ethyl ester or the hydroxy substituted derivative of the 4-cyano-group-3-hydroxy butyric acid ethyl ester in one step under the condition of not hydrolyzing an ester group in the substrate or producing any byproduct, and overcomes the defects of more byproducts, low target product yield, low optical purity and the like brought by a conventional synthetic method in a hydrolyzing process, such as a chemical method.