210 results about "Glutaric acid" patented technology

The invention provides a chiral resolution method and application of a 3-aryl substituted glutaric acid monoester compound, and the method comprises the following steps: taking a substance as shown in a formula I as a starting raw material, and carrying out alcoholysis to obtain a racemic intermediate as shown in a formula IV; and splitting the intermediate shown in the formula IV, and then dissociating to obtain the compound shown in the formula III, which has a single spatial configuration and an ee value of more than 99%. A cyclic anhydride substrate with a symmetrical structure is used and reacts with alcohol to obtain racemic 3-aryl substituted glutaric acid monoester, a target configuration with high chiral purity is obtained by screening some resolution reagents and solvents and performing salifying resolution on the 3-aryl substituted glutaric acid monoester, the operation is simple, the resolution reagents are easily available in the market and can be recycled, and the method is suitable for industrial production. The method has the advantages that an expensive chiral catalyst or a harsh enzyme catalysis condition is avoided, the reaction cost is reduced, amplified production is facilitated, the ee value of a target configuration can be increased to 99% or above, and the method is an economic and environment-friendly technical route which is simple in post-treatment and convenient for amplified production.

The invention relates to the technical field of welding materials, and discloses washable semiconductor solder paste and a preparation method and application thereof. The washable semiconductor solder paste comprises scaling powder and tin powder, wherein the mass ratio of the scaling powder to the tin powder is 1: (8-9.6); the soldering flux comprises the following raw material components: a film-forming agent, composite organic acid, a thixotropic agent, a surfactant, an antioxidant and a solvent, wherein the composite organic acid is composed of succinic acid and glutaric acid according to the mass ratio of (1-3): (1-2.5). According to the washable semiconductor solder paste, the particle size, the melting point and the alloy components of the tin powder are controlled, composite organic acid composed of succinic acid and glutaric acid in a specific proportion is adopted in the soldering flux, and other components are matched with one another; the tin powder and the soldering flux in a specific mass ratio are combined, so that the prepared washable semiconductor solder paste is good in wettability, the expansion rate is larger than or equal to 85%, the storage life reaches 3 months, and the washable semiconductor solder paste can be directly cleaned with water after being welded and is high in corrosion resistance and oxidation resistance.

The application relates to an engineering bacterium for high yield of observation blue and a construction method and application thereof, and belongs to the technical field of biological synthesis of natural dyes. The engineering bacterium for high yield of observation blue expresses icd, bpsA, glnA Y405F and gdhA; the engineering bacterium knocks out acnR, yggB, glsK, aceA and ldh. By knocking out the yggB and aceA genes, performing site-directed mutation (Y405F) on the glnA gene, replacing the glsK gene with the glnA Y405F gene, replacing the acnR gene with the icd gene, replacing the ldh gene with the gdhA gene, and integrating the bpsA gene, the application can block the formation of by-products such as lactate and succinic acid in the observation blue synthesis process, improve the flow direction of the citric acid->isocitric acid->alpha-ketoglutaric acid->glutamic acid->glutamine path, and then improve the intracellular glutamine concentration, so that the yield of observation blue is improved.

The invention provides a plasmid, an alpha-ketoglutaric acid engineering strain and a construction method and application of the alpha-ketoglutaric acid engineering strain, the strain is obtained by adopting a directional transformation method, transcriptional levels of katE, katG, sodB and grxA genes are up-regulated, a catR gene and a katA gene are heterologously expressed, a high-copy plasmid pETKG is carried, and the plasmid simultaneously expresses L-glutamate oxidase LGOX genes from Streptomyces sp and Chain A; the strain self-synthesized catalase eliminates H2O2 generated in the process of producing alpha-ketoglutaric acid through enzyme catalysis, engineering bacteria of L-glutamate oxidase LGOX expressed by pETKG plasmids are used for performing whole-cell catalysis on L-sodium glutamate to synthesize alpha-ketoglutaric acid, and the engineering strain is a high-level engineering strain capable of industrially and stably producing alpha-ketoglutaric acid.

The invention relates to the technical field of fabrics, and discloses a cool antistatic comfortable fabric and a preparation method thereof.The cool antistatic comfortable fabric is obtained by reacting pentanebis (glycine), 1, 3-bis (3-glycidyl ether oxypropyl) tetramethyldisiloxane, epoxy chloropropane and the like to obtain an epoxy quaternization finishing agent and finishing a cotton fabric. The epoxy quaternization finishing agent contains a flexible siloxane structure, can improve the softness and wrinkle resistance of the cotton fabric, contains quaternary ammonium salt and carboxyl hydrophilic groups, enables the cotton fabric to keep good hydrophilicity and cool hand feeling, contains quaternary ammonium salt cations, can increase the conductivity of the surface of the cotton fabric, and improves the anti-wrinkle performance of the cotton fabric. The surface resistivity is reduced, so that the anti-static performance is improved, and the cotton fabric still keeps good soft anti-wrinkle performance and anti-static performance after being washed for multiple times.

The invention belongs to the technical field of health-care food, and particularly relates to a composition and oral drops with the effects of dispelling the effects of alcohol, protecting the liver and relieving hangover as well as a preparation method and application of the composition and the oral drops. The invention provides a composition taking silybin eutectic crystal, curcumin eutectic crystal, ampelopsis grossedentata extract, pyrroloquinoline quinone disodium salt, reduced glutathione, alpha-ketoglutaric acid, vitamin, hericium erinaceus extract, frankincense extract, licorice extract and the like as main active ingredients, and the composition is subjected to scientific formula screening and functional verification, and has the advantages that the composition has the obvious curative effect, and the curative effect is obvious; the traditional Chinese medicine composition can effectively improve the metabolism of ethanol, protect liver and gastric mucosa, and is helpful for relieving hangover-related symptoms such as fatigue, thirst, sleepiness, headache, dry mouth, stomachache, nausea, hypomnesis, inattention and the like.

The invention aims to disclose a special dietary preparation based on alpha-ketoglutaric acid as well as a preparation process and application thereof, and relates to the technical field of dietary supplements. Every 800 mg of the dietary preparation comprises 50 mg to 100 mg of alpha-ketoglutaric acid or alpha-ketoglutaric acid salt, 5 mg to 12 mg of N-acetylneuraminic acid or N-acetylneuraminic acid salt, 30 mg to 60 mg of ergothioneine, 100 mg to 150 mg of a desert cistanche deserticola water extract or 50 mg to 80 mg of desert cistanche deserticola total glycosides, and auxiliary materials. The alpha-ketoglutaric acid salt is any one or more of alpha-ketoglutaric acid calcium, alpha-ketoglutaric acid sodium and alpha-ketoglutaric acid magnesium; the N-acetylneuraminic acid salt is any one or more of N-acetylneuraminic acid calcium, N-acetylneuraminic acid sodium and N-acetylneuraminic acid magnesium; the special dietary preparation has the beneficial effects that the special dietary preparation simultaneously contains alpha-ketoglutaric acid or alpha-ketoglutaric acid salt, N-acetylneuraminic acid or N-acetylneuraminic acid salt, ergothioneine and the cistanche deserticola aqueous extract, and has the effects of delaying senescence, resisting fatigue, improving the symptom of kidney-yang deficiency and enhancing immunity for males aged more than 45 years old.

The invention discloses a biosensor responding to glutaric acid concentration, and belongs to the technical field of biochemical engineering. According to the invention, regulatory protein and promoter elements are constructed on PSC101 series plasmids to obtain the biosensor responding to glutaric acid concentration. By performing point mutation on a-10 region and a-35 region of the response promoter PgcdH and optimizing expression of regulatory protein through the promoter and RBS engineering, the response sensitivity is improved, the response range is widened, and the application prospect in the field of glutaric acid high-yield strain screening is very wide.

The invention relates to the technical field of natural product extraction, and particularly discloses a method for extracting astaxanthin from haematococcus pluvialis. According to the method, a deep eutectic solvent (DES) composed of sodium alpha-ketoglutarate and lactic acid is adopted as an extraction medium, the molar ratio of the sodium alpha-ketoglutarate to the lactic acid is 1: 1-1: 4, water bath ultrasonic extraction is carried out at the temperature of 25-50 DEG C, and the liquid-solid ratio is 10: 1-40: 1. Experiments show that under the optimal condition, the astaxanthin extraction rate and the DPPH free radical scavenging rate are obviously superior to those of a traditional solvent method. The method has the characteristics of greenness, high efficiency and simplicity and convenience in operation, and provides a new strategy for astaxanthin extraction.

The invention relates to the field of synthetic biology, metabolic engineering and fermentation engineering, and discloses a genetically engineered bacterium and application thereof in production of alpha-ketoglutaric acid.The genetically engineered bacterium comprises the steps that the genetically engineered strain with escherichia coli BW25113 or corynebacterium glutamicum ATCC13032 as a host is constructed; overexpression type isocitrate dehydrogenase genes are integrated through chromosomes, alpha-ketoglutarate dehydrogenase complex genes are knocked out, NADPH invertase is overexpressed through plasmids, and exogenous AKG transporter protein is introduced, so that metabolic flux directional regulation and control and product efflux enhancement are realized; meanwhile, a staged fermentation process is adopted and comprises dynamic gradient adjustment of inorganic phosphorus concentration and two-stage pH control. According to the method, the AKG yield of 78.2 g / L can be obtained under the 5L tank scale, the sugar acid conversion rate reaches 0.68, and the method has the advantages of being high in yield, low in byproduct and controllable in cost. The obtained AKG is suitable for a plurality of fields such as medical intermediates, functional foods and cell culture additives, and has wide industrial application prospects.

The invention discloses a cephalotaxus hainanensis Ch2OGD1 gene and application thereof, and belongs to the technical field of gene engineering. The Ch2OGD1 gene is used for coding a 2-oxoglutaric acid dependent dioxygenase (2OGD) type Pictet-Spengler enzyme, and the Pictet-Spengler enzyme is used for coding a Pictet-Spengler enzyme. Through a tobacco transient expression system and in-vitro enzyme activity determination, the Ch2OGD1 is proved to be capable of specifically catalyzing the condensation of dopamine and 4-hydroxyphenylpropanal to generate 1-phenethyl isoquinoline. The invention provides a directional preparation method of 1-phenethyl isoquinoline based on the Ch2OGD1 gene, provides a key enzyme element for biosynthesis of a cephalotaxine alkaloid precursor compound, and provides a technical basis for expanding the application of the gene in plant genetic engineering. And a potential technical path is provided for relieving the problem of resource shortage of cephalotaxine alkaloids.

The invention discloses a flue gas wet desulphurization composite nano synergist and a preparation method thereof, the flue gas wet desulphurization composite nano synergist comprises the following components by mass: 60-70 parts of organic acid, 10-20 parts of a nano metal oxide compound, 5-10 parts of a surfactant, 3-8 parts of a pH value regulator, and 3-8 parts of a dispersant; the organic acid is a mixture of adipic acid and glutaric acid; the nano metal oxide compound is a mixture of nano titanium dioxide, nano zinc oxide and nano copper oxide, and the mass ratio of the nano titanium dioxide to the nano zinc oxide to the nano copper oxide is (2-5): (1-4): 1. The problems that in an existing desulfurization process, the desulfurization efficiency is low, the limestone utilization rate is not high, equipment is prone to scaling and corrosion, and desulfurization by-products are poor in quality are solved. The desulfurization synergist can significantly improve the desulfurization efficiency, reduce the operation cost, reduce the damage to equipment, and improve the overall performance and stability of a desulfurization system.

A method for manufacturing a die bonding film includes a first step of preparing a raw material varnish containing silver-containing particles manufactured by a reductive method or silver-containing particles of which the surfaces are treated with a surface treatment agent, a glutaric acid, and an organic solvent, a second step of mixing the raw material varnish to obtain an adhesive varnish, and a third step of applying the adhesive varnish to a support film, and removing the organic solvent to obtain a die bonding film. The content of the silver-containing particles is 70% by mass or more, on the basis of the total solid content of the adhesive varnish.

The invention discloses a synthesis method of a glutaric acid ester compound, which comprises the following steps: reacting a propionate compound as shown in a formula 1 with a diazo compound as shown in a formula 2 in a solvent in a nitrogen atmosphere in the presence of a reducing agent under the illumination condition of visible light, and after the reaction is completed, separating out the glutaric acid ester compound, thereby obtaining the glutaric acid ester compound. And separating and purifying the reaction mixture to obtain the glutaric acid ester compound as shown in the formula 3. The propionate compound and the diazo compound are used as reaction substrates, the compound can be generated through reaction under mild conditions, the yield of the target product is improved, operation is easy and convenient, the reaction conditions are mild, the price of raw materials and solvents used in the whole process is low, and cost control is facilitated.

The invention discloses a reverse-age anti-aging traditional Chinese medicine compound composition containing 2-oxoglutaric acid and a preparation method of the reverse-age anti-aging traditional Chinese medicine compound composition. The composition comprises ganoderma lucidum peptide, astragalus peptide, ginseng peptide, 2-oxoglutaric acid, gamma-aminobutyric acid, rehmannia, cistanche, Chinese yam, rhizoma polygonati, honeysuckle, dendrobium officinale and turmeric. The ganoderma lucidum peptide, the astragalus peptide, the ginseng peptide and other components cooperate with one another, so that free radicals can be removed, oxidation reaction can be inhibited, cell membranes can be stabilized, cell oxidative damage can be reduced, and senescence can be delayed. Components such as honeysuckle and turmeric can inhibit inflammation signal channels and reduce inflammatory factors, dendrobium officinale can regulate inflammatory cells, and astragalus membranaceus peptide and ginseng peptide can enhance immunity and reduce inflammatory hazards. In the cellular level, 2-oxoglutaric acid is used for supplying energy and regulating genes, and gamma-aminobutyric acid is used for improving sleep and promoting repair; on the whole, the multiple components can tonify vital qi, nourish viscera, improve qi and blood and improve skin and mental states. Through cooperation of multiple aspects, the disease risk is reduced.

SOLVENT COMPOSITIONS The present invention relates to a solvent composition for solvent-based paints or other coatings characterized in that it comprises a combination of dimethyl glutarate and at least one other compound selected from isobutyl acetate, ethyl lactate, dimethyl 2-methylglutarate, 2-methyltetrahydrofuran, ethyl acetate, cyclopentyl methyl ether, dithoxymethane, dimethyl carbonate, dimethyl succinate, benzyl alcohol, dimethyl adipate, and glyceryl triacetate. Fig. 1

The invention belongs to the technical field of antirust agents, and particularly relates to an imidazoline derivative as well as a preparation method and application thereof. The structural general formula of the imidazoline derivative is shown in the specification, and in the structural general formula, R1 is C10-C21 straight-chain alkyl, R2 is-C2H4NHCH2-, and R3 is C12-C18 straight-chain alkyl. The preparation method comprises the following steps: adding fatty primary amine into beta-ketoglutaric acid, and reacting to obtain an intermediate; adding alkyl amine ethyl imidazoline into the intermediate, simultaneously adding an aldehyde compound and a solvent, reacting at 120-140 DEG C for 3-5 hours, and carrying out reduced pressure distillation and filtration to obtain a target product. The imidazoline derivative disclosed by the invention has excellent oil solubility, anti-rust performance and antifriction performance.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

The application discloses a kind of for tape bottom layer on ultraviolet light solidification dip coating ink, the ultraviolet light solidification dip coating ink is composed of the following weight parts of component: photocuring oligomer: 30-50 parts, functional active monomer: 20-50 parts, photo initiator: 3-6 parts pigment: 5-35 parts, dispersing agent: 1-3 parts, surface auxiliary agent: 1-2 parts;The synthesis steps of the photocuring oligomer are: after epoxy E51 is mixed with octandioic acid, under the condition of nitrogen protection, temperature is controlled 115 DEG C, reaction 3-4h, when acid value is less than 10mgKOH / g, reduce reaction temperature to 85-95 DEG C, add polymerization inhibitor, slowly drop catalyst and glutaric acid-3-ethyl-3-oxetane monomethyl ester, drop adding time is controlled at 30-40min, and reaction 7-8h, when acid value is less than 10mgKOH / g, control reaction temperature to 65-75 DEG C, add isocyanatoethyl acrylate and reaction 5-6h, obtain photocuring oligomer with oxetane and acrylate structure simultaneously.The application has the characteristics of low viscosity, good leveling performance, has very good adhesion on steel tape, and solidification speed is relatively fast.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

New derivatives of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4c] pyridine-3-carboxamide (Apixaban) able to increase its water solubility. These derivatives are cocrystals derivatives ofApixaban of different acids, from which the most outstanding are the following: Apixaban Malonic Acid derivative, Apixaban-a-Ketoglutaric Acid derivative, Apixaban-Gallic Acid derivative, Apixaban-Maleic Acid derivative, Apixaban-L-Tartaric Acid derivative, and Apixaban Citric Acid derivative.

The invention belongs to the technical field of crystal form drug molecules, and particularly relates to a preparation method and application of a baricitinib and glutaric acid eutectic acetonitrile solvate. The eutectic compound disclosed by the invention is good in solubility, and the bioavailability of the baricitinib is remarkably improved. The preparation process is simple. Good medical industrial application prospects are realized.

The invention discloses a genetically engineered bacterium for synthesizing N-acetyl blue as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium is prepared by knocking out a lactic dehydrogenase gene ldh and inserting a phosphoketolase gene xfpK on a knockout site, knocking out a pyruvate oxidase gene poxB and inserting a phosphate transacetylase gene pta on a knockout site of a microorganism for producing N-acetyl blue, and knocking out an aconitase inhibition factor gene acnR, inserting a glutamate dehydrogenase gene gdhA on a knockout site, knocking out a glutamine synthetase adenylation transferase gene glnE, and inserting an alpha-ketoglutarate dehydrogenase inhibition factor gene odhI on a knockout site to obtain the strain. According to the method, the supply of the precursor acetyl coenzyme A is enhanced by introducing a non-oxidative glycolysis pathway, the pH dynamic regulation system balances the metabolic flux, and the double breakthrough of the yield and the carbon recovery rate of the N-acetyl blue is realized by combining a two-stage fermentation process.

The present invention relates to the technical field of crop breeding, and specifically discloses a composition for Co-60γ ray irradiation mutagenesis breeding of Dendrocalamus brandisii, which is composed of an irradiation pretreatment solution and an irradiation post-treatment solution. The present invention also provides a method for breeding Dendrocalamus brandisii by Co-60γ ray irradiation mutagenesis, which includes soaking the seeds of Dendrocalamus brandisii in an irradiation pretreatment solution containing L-hydroxyproline to fully imbibe them, irradiating them with Co-60γ rays at a semi-lethal dose, and then treating them with an irradiation post-treatment solution containing 2-hydroxyglutaric acid, glutathione and vitamin C. The method of the present invention effectively improves the mutagenesis efficiency of Dendrocalamus brandisii by adding L-hydroxyproline as an inducer for specific pretreatment before irradiation, adding 2-HG as an irradiation sensitizer, and adding GSH and Vc as radiation protectors for post-treatment after irradiation. Mutant plants with excellent traits are screened and can be used as new germplasms or new varieties of bamboo.

This invention provides a continuous preparation method for dimethyl 2-methylglutarate, carried out in a first microchannel reactor and a second microchannel reactor connected in series. The method includes: feeding 2-methylglutaronitrile and sulfuric acid solution into the first microchannel reactor for hydrolysis; and contacting them with methanol in the second microchannel reactor for esterification. The esterified material is then subjected to phase separation to obtain dimethyl 2-methylglutarate. The mass ratio of 2-methylglutaronitrile to sulfuric acid solution is 1:(5~20). The controlled temperature of the first microchannel reactor is 80~120℃; the controlled temperature of the second microchannel reactor is 65~105℃, and the controlled temperature of the second microchannel reactor is not higher than that of the first microchannel reactor; the mass ratio of 2-methylglutaronitrile to methanol is 1:(1~6). Through the synergistic operation of the microchannel reactor and multiple control parameters, the eutectic precipitation of intermediate products with ammonium sulfate can be avoided, clogging can be prevented, and efficient, high-yield continuous preparation can be achieved.

The invention relates to the technical field of catalysts, and discloses a boron-doped zinc glutarate nanoflower catalyst as well as a preparation method and application thereof, and the Nano-ZnGA-B nanocatalyst has a nanoflower morphology formed by cross assembly of thin sheets with relatively small sizes and relatively thin sheet layers. According to the preparation method, a nano-ZnGA-B nanoflower catalyst is synthesized by taking a surfactant containing amide carbonyl as a modifier and taking a boron-containing ligand as a dopant through a hydrothermal method, and the nano-ZnGA-B nanoflower catalyst is prepared through a simple and efficient chemical method. The catalyst shows excellent catalytic performance, and can catalyze the polymerization of propylene oxide and carbon dioxide under mild temperature (60-70 DEG C) and pressure conditions (3-4 MPa) to prepare the polypropylene carbonate with high thermal stability and good comprehensive performance, so that the degradable polypropylene carbonate product has wider application prospect and market value in industrial production.

The invention discloses a preparation method of a novel bio-based copolyester material, and belongs to the field of green high polymer materials. According to the method, a furan carboxylic acid source, a pentanediol source and glutaric acid are used as raw materials, and the poly (neopentyl glycol glutarate-co-neopentyl glycol furandicarboxylate) series random copolyester is synthesized through ester exchange and condensation polymerization. The method comprises the following operation steps: mixing a furan carboxylic acid source, a pentanediol source and glutaric acid according to a molar ratio, adding a catalyst, sequentially carrying out heating reaction in an inert gas atmosphere, carrying out vacuum polycondensation, dissolving and precipitating, and drying to obtain a target product. The obtained copolyester material is controllable in composition and stable in structure, and has good thermal stability (Tdmaxgt; the glass transition temperature (4-64 DEG C) is adjustable, the mechanical property is excellent, the highest elongation at break can reach 917%, and the Young modulus can reach 1963 MPa. The material performance can be continuously regulated and controlled along with the monomer feeding ratio, and the material has wide application prospects in the aspects of elastomers, high-barrier thermoplastic materials and the like. The method is simple in process, raw materials are easy to obtain, and the method is suitable for sustainable development of the high-performance full-bio-based plastic.

COMPOSITIONS AND PROCESSES FOR REMOVING HAIR COLOR The disclosure relates to compositions and processes for removing color from keratinous fibers such as hair. The compositions include (a) at least one reducing agent selected from glutaric acid, glyoxylic acid, thiolactic acid, thioglycolic acid, glycolic acid, citric acid, or combinations of two or more of these, (b) at least one amino acid, (c) optionally, at least one amine compound, and (d) at least one solvent. Figure for abstract: none

Provided are co-crystals of Compound (I) and glutaric acid useful in the treatment of cancer and methods of preparing the same, pharmaceutical compositions thereof and uses for the treatment of cancer comprising administering the co-crystals described herein to a patient in need thereof.