1607 results about "Formulary" patented technology

The disclosure provides compounds, e.g., compounds of Formula I, and their use in treating medical diseases or disorders, such as cancer. Pharmaceutical compositions and methods of making various indene compounds are provided. The compounds are contemplated to be modulators of Ras (e.g., K-Ras).

Provided herein are compounds, such as compounds of Formula (I), Formula (l-A), Formula (l-AA), or Formula (l-BB), or pharmaceutically acceptable salts of any one thereof, useful for modulating KRAS GD12 and / or other G12 mutants.

Provided herein are compounds, such as compounds of Formula (I), Formula (l-A), Formula (l-AA), or Formula (l-BB), or pharmaceutically acceptable salts of any one thereof, useful for modulating KRAS GD12 and / or other G12 mutants. (I)

The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.Accordingly, the present invention relates to compounds of formula (Id)whereinR1 is H and R2 is selected from one of the substituents (i) and (ii) below; orR1 is selected from one of the substituents (i) and (ii) below and R2 is H; orR1 and R2 are both represented by substituent (i) below; orR1 and R2 are both represented by substituent (ii) below; orR1 is substituent (i) and R2 is substituent (ii); orR1 is substituent (ii) and R2 is substituent (i);wherein * indicates the attachment point; andwherein the carbon atom at the attachment point on substituent (i) is in the S-configuration; or a pharmaceutically acceptable salt thereof.

The invention relates to the technical field of nutrition health care product customization, and discloses a personalized adult nutrition health care product customization system and method. The method comprises the following steps: collecting biological characteristics, dietary habits, health targets and gene detection data of a user, and constructing a nutritional requirement database through labeling and preprocessing; a multi-dimensional nutrition demand tensor is generated through principal component analysis, clustering analysis and the like, the matching degree of a target user and a representative sample is calculated, a weighted matching degree vector is obtained through neural network optimization, and then a personalized nutrition formula substrate is generated and optimized through a genetic algorithm. Kalman filtering is used for adjusting a formula according to real-time health data of a user, monitoring deviation to trigger reconstruction, associating a historical scheme to update a nutrition rule base, and finally outputting a nutrition formula coded as a production instruction, so that accurate personalized customization is realized, and nutrition is safe, reasonable and traceable.

The invention discloses a flotation reagent formula optimization method and system based on data analysis, and the method comprises the steps: monitoring the ore pulp of a flotation tank in real time through an online detection device, obtaining a mineral grade, reagent concentration and foam thickness data set, processing the data set based on a time-delay analysis algorithm, generating a reagent association feature library, and carrying out the optimization of the flotation reagent formula. And clustering the feature library according to medicament types to construct an effect association map, calculating the map by using a multi-objective optimization algorithm to generate a candidate formula set, screening and determining an optimal formula according to cost constraint, and controlling a medicament adding device to execute adjustment. According to the method, the problem that an existing flotation reagent formula optimization technology is lack of reagent synergistic effect quantitative analysis and time sequence correlation modeling is solved, and the scientificity and accuracy of reagent formula optimization are improved.

The specification relates to conjugates comprising a linker of Formula (IA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Provided herein are compounds of formula (I), or pharmaceutically acceptable salts or deuterated forms thereof, wherein ring A, R1, R2, R3, R4, and m are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I) or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I) or pharmaceutically acceptable salt or deuterated form thereof, e.g., in the treatment of a disease that is treatable by administration of a DPP1 inhibitor.

The invention relates to an intelligent algorithm recommendation method and system for pet personalized prescription food. The method comprises the following steps: acquiring physiological information of a pet, and analyzing the physiological information to obtain a specific physiological demand vector; then, combining the demand vector with a nutriology standard database, and calculating to obtain a nutrition proportioning scheme; then, deviation analysis is carried out on the recent diet record and health feedback data of the pet according to the nutrition proportioning scheme, adjustment demand parameters are obtained, and when the adjustment demand parameters exceed a preset threshold value, iterative optimization is carried out on the nutrition proportioning scheme to obtain personalized nutrition proportioning; screening food material combinations according to the personalized nutrition ratio to obtain a prescription food formula recommendation list for each pet; and finally, based on the prescription grain formula recommendation list and the physiological data after ingestion, generating a new prescription grain formula recommendation list. The pet nutrition scheme can be planned in advance, and nutrition balance of pets in different growth stages and health states can be guaranteed comprehensively.

The invention discloses a rhizoma menispermi medicinal material and formula granule UPLC (Ultra Performance Liquid Chromatography) identification method, which is characterized in that specified values of relative retention time of the rhizoma menispermi medicinal material and formula granule are determined through a high performance liquid chromatography, and the relative retention time of a corresponding test solution is respectively within + / -10% of the corresponding specified values of the rhizoma menispermi medicinal material and formula granule. The method can effectively identify the rhizoma menispermi medicinal material and the formula granules, can be used for identifying rhizoma menispermi and counterfeit berba aristolochiae mollissimae and subprostrate sophora medicinal materials and formula granules, and can also be used for identifying rhizoma coptidis, cortex phellodendri, caulis sinomenii and other medicinal materials containing alkaloid components and formula granules. The method overcomes the defects of the existing method, and has the characteristics of simplicity in operation, good stability, rich chromatographic peak information amount, good repeatability and high stability.

The invention relates to an intelligent wafer etching process in the technical field of information, and the process comprises the steps: obtaining the etching rates of different materials under various liquid medicine formulas, constructing an etching rate database covering various material systems, screening out a material combination with high etching selectivity by comparing the etching rate differences in the database, and carrying out the etching of the material combination. Determining a targeted liquid medicine formula optimization direction; a multi-parameter online monitoring unit is installed in etching equipment, the concentration of liquid medicine is measured in real time through an optical fiber spectrometer, the temperature and the pH value of the liquid medicine are measured in real time through a thermocouple and a pH electrode, when monitoring parameters exceed a set range, a liquid medicine proportion adjusting program is started, and dynamic regulation and control over the property of the liquid medicine are achieved by controlling the liquid inlet amount and the liquid outlet amount. And the stability and the consistency of the etching process are ensured.

The invention discloses an internet-based pharmaceutical equipment intelligent monitoring and process optimization method and system, and relates to the technical field of pharmaceutical equipment process optimization, and the method comprises the steps: recognizing the potential non-uniform characteristics of an upstream process, predicting the dynamic change trend of the upstream process, and then evaluating the influence on the temperature, pressure and flow through combining with a neural network model, thereby achieving the intelligent monitoring and process optimization of the upstream process. And dynamically adjusting downstream parameters. And when the deviation exceeds a threshold value, fusing the state data of the equipment to judge the deviation of the stirring speed, inquiring a formula compatible database to generate an optimized downstream process parameter set, and verifying the batch consistency. And the real-time monitoring cycle automatically updates data, activates the real-time monitoring cycle, automatically updates the upstream process and the downstream process when dynamic change occurs, and ensures stable output of pharmaceutical batch quality. Real-time cooperative monitoring of all procedures in pharmaceutical production is achieved through the internet technology, downstream process parameters are automatically adjusted according to dynamic changes of the upstream procedures, and production efficiency and quality stability are improved.

The invention relates to the technical field of formula foods for special medical purposes, and discloses a low-GI formula food suitable for diabetics and a preparation method thereof, the low-GI formula food comprises the following raw materials by weight: 4-6% of protein, 2-4% of fat, 10-15% of carbohydrate, 2.5-4.5% of dietary fiber, 0.3-0.5% of mineral, 0.3-0.5% of vitamin, 3-5% of food additive, and the balance purified water. The full-nutrition formula food for the diabetes mellitus with special medical application meets the metabolic characteristics and nutritional requirements of people suffering from the diabetes mellitus in China, and provides a more scientific nutrition intervention means for people suffering from the diabetes mellitus in China.

The invention belongs to the technical field of health-care products, and particularly relates to a formula helpful for improving sleep and a preparation method thereof. Comprising the following raw material components in parts by weight: 90-110 parts of spina date seed powder, 45-55 parts of casein hydrolysate peptide powder, 15-22 parts of gamma-aminobutyric acid, 18-22 parts of lucid ganoderma powder, 15-22 parts of lily powder, 18-20 parts of poria cocos powder, 12-15 parts of tea leaf theanine and 1-4 parts of lactobacillus plantarum JYLP-326. According to the formula for improving sleep provided by the invention, the limitation of an existing insomnia treatment means is broken through through a three-dimensional synergistic network of traditional Chinese medicines, probiotics and functional components, and the formula realizes systematic improvement on insomnia core symptoms through multi-channel synergy of nerve regulation, intestinal brain axis intervention and immune balance, namely rapid induction of sleep.

Provided herein are compounds of Formula (I), Formula (II), Formula (III), a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or a pharmaceutically acceptable salt or deuterated form thereof, wherein R1, R2, R3, R4, RD, RG, p and q are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of formula (I), or a compound selected from any of the compounds in Table 1, Table 2, Table 3, Table 4 or pharmaceutically acceptable salt or deuterated form thereof, and methods of using a compound of formula (I), Formula (II), Formula (III), or pharmaceutically acceptable salt or deuterated form thereof, e.g., in treating 5-HT2A receptor associated diseases or disorders. (I), (II), (III).

The invention discloses a traditional Chinese medicine plant combination anti-hair loss and hair growth formula optimization method based on a neural network algorithm, and the method comprises the following steps: S1, collecting hair health data of a user, and building a personalized health file; s2, based on the health record, analyzing the physiological and psychological states of the user in real time, and establishing an emotion-hair growth feedback mechanism to evaluate the risk of alopecia; s3, analyzing the health archive by using a deep neural network, predicting an alopecia trend and generating a personalized alopecia prevention and hair growth scheme; s4, matching optimal plant components and proportions through a neural network optimization model, and dynamically adjusting a pharmacodynamic model; s5, adaptively adjusting the plant formula proportion through a quantum neural adaptability learning mechanism; s6, simulating different formula effects through the virtual test platform, optimizing the formula and feeding back to the health file; and S7, forming a closed-loop feedback mechanism through continuous user feedback and physiological monitoring results, and regularly optimizing the formula. Through personalized analysis and dynamic adjustment, an accurate anti-hair loss and hair growth solution is provided.

The invention provides a construction method of fingerprint spectrums of katsumadai medicinal material, standard decoction and formula granules thereof, which comprises the following steps: preparing a mixed reference solution from alpinetin, pinocembrin, cardamonin and alnudinone; preparing a test solution from the alpinia katsumadai medicinal material, the standard decoction or the formula granules; respectively detecting the reference solution and the test solution by adopting a high performance liquid chromatography, and constructing fingerprints of the alpinia katsumadai medicinal material, the standard decoction and the formula granules of the alpinia katsumadai medicinal material; wherein the conditions of the high performance liquid chromatography are as follows: a mixed solution of acetonitrile and methanol is taken as a mobile phase A, a phosphoric acid aqueous solution with the volume concentration of 0.08%-0.12% is taken as a mobile phase B, and a gradient elution procedure is adopted. The method has the advantages of being simple, stable and high in specificity, and a comprehensive, effective and rapid evaluation method is provided for quality control of alpinia katsumadai medicinal materials, standard decoction and formula granules of the alpinia katsumadai medicinal materials.

The invention discloses a construction method and an identification method of characteristic chromatograms of a senecio scandens medicinal material as well as decoction pieces, standard decoction and formula granules thereof, and relates to the technical field of traditional Chinese medicine identification. The construction method of the specific chromatogram comprises the following steps: extracting a to-be-detected sample with methanol to obtain a test solution; the method comprises the following steps: dissolving 5-caffeoylquinic acid, chlorogenic acid, caffeic acid, 4-caffeoylquinic acid, rutin, hyperoside, isoquercitrin and 4, 5-dicaffeoylquinic acid with methanol to obtain a reference solution; and a liquid chromatograph is adopted for determination. A chromatographic column of the liquid chromatograph takes phenyl-methyl polysiloxane as a stationary phase, acetonitrile as a mobile phase A and 0.05 vol%-0.3 vol% formic acid aqueous solution as a mobile phase B for gradient elution. The information of the characteristic chromatogram constructed by the method is rich, and the quality of the senecio scandens medicinal material, decoction pieces, standard decoction and formula granules can be quickly and comprehensively reflected.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to an optimization method and system for a stir-frying process of traditional Chinese medicine decoction pieces. Acquiring formula information and process requirements of the target traditional Chinese medicine decoction pieces; retrieving a stir-frying process scheme of the similar traditional Chinese medicine decoction pieces from the traditional Chinese medicine stir-frying expert knowledge base; fusing the stir-frying process scheme to generate initial parameters; performing a first round of stir-frying; collecting process data through a multi-mode sensor; an expert evaluates and provides an adjustment suggestion; generating a parameter adjustment scheme in combination with expert suggestions and process data; executing multiple rounds of interactive optimization; and recording the optimal frying process parameters and storing the optimal frying process parameters in a knowledge base. A closed-loop optimization system is formed by constructing a knowledge retrieval mechanism driven by formula information, a multi-modal sensing monitoring system, a parameter adjustment strategy combining expert evaluation and data analysis and an interactive iterative optimization framework. The technical problems of difficulty in knowledge reuse, single process monitoring, lack of system support for parameter adjustment, insufficient man-machine collaboration and the like in the traditional Chinese medicine stir-frying process are solved.

The invention provides a traditional Chinese medicine formula with effects of releasing stasis and removing stasis, which belongs to the technical field of traditional Chinese medicines, and is innovatively and creatively embodied in three aspects: in the aspect of medicinal material composition, plateau herbal medicines are taken as main raw materials, scientific compatibility of low-altitude herbal medicines is fused, a comprehensive and powerful combination is formed, and a synergistic effect is exerted; complex diseases are handled to achieve the purpose of releasing stasis and eliminating stagnation; according to the manufacturing process, different processing methods are adopted according to different herbal characteristics, and through precise process control and advanced appliance application, such as strict drying temperature and time control, fine washing and baking steps, precise decoction process by means of modern scientific appliances and the like, the full release of the medicine effect is ensured, and the loss of the medicine effect is reduced; the stability and the consistency are improved; the use method is innovative, four modes of soaking, eating, drinking and atomizing are used together and matched dialectically, the method adapts to differences of patients, and pertinence and effectiveness are improved. In actual production, the process is simplified, time and cost are reduced, large-scale production is easy, market requirements are met, quality and fineness are emphasized, side effects are reduced, safety, treatment experience and life quality are improved, breakthrough improvement is brought, and efficient, safe and convenient treatment requirements of patients are met.

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X1 and X2 are independently C or N, provided that zero or one of X1 and X2 is N; Ring A represented by the structure is: or; and Q, R1, R2, R3, R4, R6, and p are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

The invention relates to the technical field of medical information processing, in particular to a liver, gall and pancreas postoperative intelligent support system and method for dynamic nutrition metabolism analysis, and the system comprises a multi-source metabolism data collection module which obtains the body composition, stool spectrum and enteral nutrition parameter data of a patient in real time, the dynamic metabolic state modeling module constructs a patient postoperative metabolic state model by using the data and evaluates the patient postoperative metabolic state model, the multi-objective optimization decision module calculates and generates an optimal nutrition scheme through a multi-level objective function based on an evaluation result, and the precise nutrition formula generation module generates a detailed nutrition formula and infusion parameters according to the optimal nutrition scheme. The complication early warning and feedback module calculates complication risk levels, sends early warning information and feeds back and adjusts a nutrition scheme according to the collected data and evaluation results, the metabolic state of the patient is evaluated comprehensively and accurately, precise nutrition support and complication early warning are achieved, and the nursing level of the liver, gall and pancreas postoperative patient is improved.

This disclosure provides compounds of Formula (I) (e.g., Formula (I-a), (I-a1), (I-b), or (I-c)), or pharmaceutically acceptable salts thereof, that induce degradation of a BCL6 protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing compounds of Formula (I) (e.g., Formula (I-a), (I-a1), (I-b), or (I-c)), or pharmaceutically acceptable salts thereof, as well as methods of using and making the same

The present invention provides a fluorescent chemical sensor array for detecting infant formula milk powder and a method for detecting infant formula milk powder using the same. The fluorescent chemical sensor array includes the following sensor units: a first sensor unit, which is a compound having the structure shown in Formula I (i.e., PPE2); a second sensor unit, which is a compound having the structure shown in Formula II (i.e., PPE-SO3); and a third sensor unit, which is a compound having the structure shown in Formula III (i.e., PPE-N1). In Formula I, Formula II, and Formula III, n is independently 9-60. The present invention can use the fluorescent chemical sensor array and the LDA pattern recognition algorithm to detect and distinguish different types, different origins, and different brands of infant formula milk powder, and can optimize the sensor array to achieve the purpose of differentiating detection with the least number of sensing units.

Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof. Another method includes: administering once-daily to the subject in need thereof, an oral load dose formulation having from 240 mg to 480 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof, and thereafter administering once-daily to the subject, an oral maintenance dose formulation having 80 mg to 160 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N′-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

The invention discloses a preparation process of crocodile penis peptide wine for improving kidney deficiency, and relates to the technical field of biology, the process comprises the steps of raw material pretreatment, collaborative graded enzymolysis, starter propagation, sand feeding, sand roughening, starter addition and stacking fermentation, distillation for wine taking and fine adjustment. Wherein the synergistic graded enzymolysis adopts a mixed enzymolysis technology, lecithin and phytic acid are added, and natural pH gradient is combined, so that the problems of wine precipitation and taste layering are effectively solved, and the product stability and the polypeptide retention rate are improved. Meanwhile, a traditional Chinese medicinal material compound formula is fused in the process, and the health-care effect is enhanced through the synergistic effect of enzymolysis and fermentation. The wine can significantly increase the content of testosterone in serum and the physical endurance, and improve the symptom of kidney deficiency. The method is mature in process, high in product quality and suitable for large-scale production.

Disclosed herein is a method for execution by a drug delivery device for determining an optimal dose of a liquid drug for current cycle of a medication delivery algorithm, the method utilizing a stepwise evaluation of a model and a cost function across a coarse search space consisting of coarse discrete quantities of the drug and a refined search space consisting of refined discrete quantities of the drug.