771 results about "Insomnia" patented technology

The invention provides a transcranial stimulation control method, a transcranial stimulation control system and a computer readable storage medium, and the method comprises the steps: collecting an electroencephalogram parameter signal, and converting the electroencephalogram parameter signal into an electroencephalogram feature vector; inputting the electroencephalogram feature vector into a large language model, obtaining an initial electrical stimulation signal corresponding to the electroencephalogram feature vector from a stimulation electroencephalogram knowledge model according to the electroencephalogram feature vector, and generating an initial electrical stimulation signal scheme; the initial electrical stimulation signal is optimized through an attention mechanism according to historical response data of a user, a final electrical stimulation signal scheme is output, and the historical response data of the user comprises a historical electrical stimulation signal scheme and user feedback information; and outputting the final electrical stimulation signal scheme to a transcranial stimulation module. The method can improve the insomnia treatment efficiency of the user.

The invention belongs to the technical field of food microorganisms, and relates to lactobacillus plantarum and application thereof in preparation of products for relieving insomnia. The preservation number of the lactobacillus plantarum is GDMCC No: 65061. The lactobacillus plantarum can be applied to efficient fermentation of spina date seed juice, the content of GABA, polypeptide, total phenols and total flavonoids in the spina date seed juice is increased, and the content of spinosin, 6 ''-feruloyl spinosin, jujuboside A, jujuboside B and betulinic acid is increased; the reduction of whole brain coefficient and the increase of liver coefficient caused by long-term insomnia are relieved, the bad condition caused by long-term insomnia in a hippocampus DG region in the brain of the mouse is improved, the sleep time of the mouse is prolonged, and the insomnia symptom of the mouse is relieved; the content of inhibitory neurotransmitters 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in the hypothalamus of the mouse is increased, the content of excitatory neurotransmitter glutamic acid is reduced, and the reduction of organism immunity and oxidative stress of brain tissues caused by insomnia are relieved.

The invention provides a transcranial alternating current stimulation method and system with an automatic adjustment function, and relates to the technical field of transcranial alternating current stimulation, and the method comprises the steps: obtaining, compressing and sampling a multi-channel electroencephalogram signal, carrying out the multi-channel reconstruction through the physiological priori and the related information of adjacent brain regions, extracting the feature parameters of target brain waves, and carrying out the reconstruction of the target brain waves. Based on the parameters, dual-stage transcranial alternating current signals of prior stimulation and post stimulation are output; by introducing an adjacent matrix or a graph Laplacian operator in a compressed sensing acquisition and reconstruction link, high-fidelity recovery of cross-brain region oscillation can be maintained under the conditions of low sampling rate and noise; performing layered screening and dynamic fine tuning on characteristic frequency bands of different brain regions by combining general and individualized prior; the target brain wave phase is locked in advance in the first stimulation stage, and the stimulation intensity of each brain region is independently or cooperatively adjusted in the later stimulation stage, so that the requirement of coupling regulation and control of multiple brain regions is met, and the closed-loop intervention effect on nerve states such as insomnia and anxiety is improved.

The invention discloses a composition for treating insomnia. Comprising probiotic compounds: lactobacillus plantarum, bifidobacterium lactis, lactobacillus crispatus, lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus reuteri, lactobacillus casei, lactobacillus bulgaricus, lactobacillus fermentum, lactobacillus gasseri, lactococcus lactis, bifidobacterium longum, lactobacillus salivarius, bifidobacterium breve, streptococcus thermophilus and lactobacillus paracasei; lactobacillus helveticus; and traditional Chinese medicine components and prebiotics. Probiotics are matched with traditional Chinese medicines with homology of medicine and food, and corresponding prebiotics are supplemented, so that the balance of intestinal flora can be adjusted and information transmission between intestines and cranial nerves can be promoted through the synergistic effect of the probiotics and the corresponding prebiotics, and then gastrointestinal inflammation, ulcer, helicobacter pylori infection, constipation and insomnia are treated or improved; and treating or improving spleen and stomach disharmony, liver qi stagnation, excessive heart fire, fire excess from yin deficiency, heart-kidney disharmony caused by emotion, pressure, diseases and the like, and insomnia caused by the symptoms.

The invention relates to the technical field of nutritional supplements. A traditional fat reducing method mainly comprises dieting, high-intensity exercise, medicine weight losing and the like. However, dieting may lead to malnutrition; high-intensity sports are difficult to insist, and sports injury is easily caused; in order to solve the technical problems, the invention discloses a fat-reducing nutritional composition capable of improving metabolism, and the fat-reducing nutritional composition can be used for solving the technical problems of severe side effects such as tachycardia, insomnia and the like caused by medicine weight loss. The composition comprises the following components in parts by weight: 13-21 parts of a bitter gourd extract, 15-31 parts of a garcinia cambogia extract, 13-17 parts of oat fibers, 17-23 parts of whey protein powder, 7-9 parts of linseed oil, 6-14 parts of a green tea extract, 9-15 parts of a calcium supplement and 15-19 parts of a purple perilla seed extract, and can provide energy for a user, supplement immune globulin, lactoferrin and a calcium source, improve the immunity of the user and improve the immunity of the user. The body metabolism level and immunocompetence are improved, absorption of fat in digestive tracts can be effectively inhibited, storage of fat in the body is reduced, fat consumption is promoted, and the fat reducing effect is achieved.

The invention discloses a personalized sleep intervention and first aid method and system based on multi-modal data fusion. The method comprises the steps that physiological index data and motion data of a user are collected in real time through wearable equipment; generating a sleep quality score based on the physiological index data in combination with a preset sleep quality evaluation model; generating a personalized sleep intervention scheme according to the sleep quality score and the motion data; the sleep intervention module is started by manually triggering or automatically detecting the insomnia state of the user; according to the physiological index data monitored in the sleeping process, the indexes exceeding the standard are recorded, and a prompt is given out after waking up the next day, or a first-aid mode is triggered. The personalized dynamic sleep intervention scheme is generated by quantifying the physiological indexes of the user, and the limitation of a single sensor is broken through; sleep intervention can be triggered in multiple modes, the intervention intensity can be dynamically adjusted according to the real-time physiological state, the first-aid mode can be automatically started, and first-aid delay is avoided.

The invention relates to an intelligent bedside instrument for relieving insomnia with assistance of sound waves. The intelligent bedside instrument comprises a sound wave adjusting module, a sound wave resonance relaxing system, a sleep state monitoring module and a personalized feedback system, the sound wave adjusting module sends specific sound waves to the sleep environment, and the sleep environment is automatically optimized based on sleep stage data monitored in real time by adjusting the frequency and intensity of the sound waves. The sound wave resonance relaxing system emits low-frequency sound waves with specific frequency into a bed head or a pillow according to the sleep state of a user, and the low-frequency sound waves are transmitted to the head and the body of the user through the resonance effect and used for relaxing tense muscles, stimulating deep nerves and helping the user to quickly relax and sleep. Through sound wave adjustment, resonance relaxation, accurate sleep state monitoring and a personalized feedback system, the sleep quality of a user is effectively improved, the user is helped to quickly enter deep sleep from a light sleep state, external interference is avoided, a sleep adjustment scheme is continuously optimized through intelligent analysis, and personalized requirements are met.

The invention discloses a multi-source confidence perception insomnia intelligent prescription recommendation method, a medium and equipment, and aims to solve the problem of low recommendation accuracy caused by insufficient multi-source heterogeneous data fusion, single feature representation and missing prediction confidence in the prior art. The method comprises the following steps: coding patient symptoms into a sparse binary matrix; extracting a symptom-traditional Chinese medicine prescription matrix and a symptom-symptom type matrix from the traditional Chinese medicine knowledge map; generating symptom-guided traditional Chinese medicine features and symptom type features through a double-layer graph convolutional neural network; calculating the prediction distribution probability of the traditional Chinese medicine prescriptions and syndromes; based on an energy function, quantifying uncertainty scores of the two; the multi-source probability is dynamically weighted and fused to improve the weight of a high-confidence result; and finally, outputting recommended prescriptions and syndrome type sequences. The accuracy and interpretability of insomnia prescription recommendation are remarkably improved through isomeric map modeling and multi-source confidence fusion, and the method is suitable for a traditional Chinese medicine clinical auxiliary decision making system.

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri ShuiMian with a sleep aiding effect and application of the lactobacillus reuteri ShuiMian. A new ShuiMian strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, PTZ is adopted to construct a zebra fish insomnia model, and research finds that the strain can inhibit eye movement frequency, inhibit brain discharge, reduce dopamine secretion, promote GABA secretion and promote Gabra gene expression, and the zebra fish insomnia model can be used for treating insomnia. The effect of promoting sleep is achieved. Therefore, the strain has a unique sleep-promoting mechanism, can assist in developing novel sleep-promoting medicines in the field of medicines, and provides a safer and more effective treatment scheme for insomnia patients. In the health care industry, a nutritional supplement can be prepared, the mass sleep quality is improved, and the development of sleep health related industries is promoted.

There is provided a computer-implemented method for determining sleep misperception of a subject during a sleep session. The method comprises receiving sleep condition information. The sleep condition information comprises at least one of SDB information and insomnia information. The SDB information is representative of a sleep disordered breathing (SDB) condition of the subject based on a number of SDB events of the subject per unit of time. The computer-implemented method comprises receiving sleep quality information representative of a quality of sleep of the sleep session experienced by the subject. The computer-implemented method comprises determining a degree of sleep misperception based on the sleep condition information and the sleep quality information. The sleep misperception is representative of a difference between a subjective total sleep time of the sleep session experienced by the subject and an objective total sleep time of the subject in the sleep session.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention belongs to the technical field of health-care products, and particularly relates to a formula helpful for improving sleep and a preparation method thereof. Comprising the following raw material components in parts by weight: 90-110 parts of spina date seed powder, 45-55 parts of casein hydrolysate peptide powder, 15-22 parts of gamma-aminobutyric acid, 18-22 parts of lucid ganoderma powder, 15-22 parts of lily powder, 18-20 parts of poria cocos powder, 12-15 parts of tea leaf theanine and 1-4 parts of lactobacillus plantarum JYLP-326. According to the formula for improving sleep provided by the invention, the limitation of an existing insomnia treatment means is broken through through a three-dimensional synergistic network of traditional Chinese medicines, probiotics and functional components, and the formula realizes systematic improvement on insomnia core symptoms through multi-channel synergy of nerve regulation, intestinal brain axis intervention and immune balance, namely rapid induction of sleep.

The invention discloses a sleep aiding method and system based on brain wave data, and the method comprises the steps: synchronously collecting brain waves, electrocardiosignals, environmental noise and user voice data through a flexible electrode array, constructing a multi-mode causal graph, and dynamically recognizing the type of a noise source (electromagnetic interference or psychological noise); the method comprises the following steps of: generating a target antagonistic intervention signal (such as reverse sound wave counteracting electromagnetic noise and binaural rhythm relieving psychological pressure) according to the target antagonistic intervention signal, generating dynamically adaptive light pulse and tactile vibration parameters in combination with a psychological-physiological collaborative model, and synchronously outputting sound, light and tactile intervention signals through a multi-modal actuator. Through causal reasoning and multi-sensory cooperative regulation and control technologies, accurate inhibition of noise interference and personalized induction of the sleep state are realized, the sleep time is remarkably shortened, the deep sleep duration is prolonged, and the method is particularly suitable for complex noise environments and anxiety-related insomnia scenes.

The embodiment of the invention discloses a sleep diagnosis method, device and equipment based on a breathing machine, and belongs to the technical field of sleep diagnose.The breathing machine comprises an electroencephalogram monitoring unit, an electro-oculogram monitoring unit and an electrocardio monitoring unit, and the method comprises the steps that electroencephalogram information is obtained through the electroencephalogram monitoring unit; through the electro-oculogram monitoring unit, electro-oculogram information is obtained; eCG information is obtained through an ECG monitoring unit; based on the electroencephalogram information, the electro-oculogram information and the electrocardio information, performing insomnia type diagnosis by combining user input information obtained based on ISI, and determining an insomnia type; and adding the OSA obstructive sleep apnea severity in the insomnia type, and generating a sleep diagnosis report. According to the method and the device, the accuracy of the insomnia type is improved, the timeliness of insomnia type diagnosis is improved, the insomnia type diagnosis is combined with the user experience, the accuracy of the insomnia type diagnosis is further improved, and the accuracy of a sleep diagnosis report is improved.

The invention relates to the technical field of foods and medicines, and discloses a composition of medicinal and edible food extracts for treating insomnia, which comprises the following components in percentage by weight: 8.92%-9.9% of gamma-aminobutyric acid (GABA), 2.97%-3.96% of phosphatidylserine, 29.7%-39.64% of spina date seed extract, 29.7%-39.64% of poria cocos extract, 0.59%-0.79% of tea leaf theanine extract and 5.95%-6.94% of fish collagen peptide. The mask comprises the following components in percentage by weight: 5.95%-6.94% of honey, 0.59%-0.79% of collagen tripeptide, 0.59%-0.79% of sodium hyaluronate, 0.59%-0.79% of rice bran oil powder, 0.59%-0.79% of haematococcus pluvialis, 0.59%-0.79% of acerola cherry extract, 0.01% of nicotinamide and 0.59%-0.79% of grape seed extract. The composition for treating insomnia based on the concept of homology of medicine and food not only overcomes the limitation of the existing therapy, but also has higher safety, wide adaptability and good user acceptability, and has positive significance for improving the life quality of insomnia people, improving the overall health level and improving the skin elasticity and luster.

The invention discloses a probiotic preparation, the preparation is composed of an effective amount of anti-TGF-beta1 monoclonal antibody, an effective amount of probiotics and other auxiliary materials, and amino acid sequences of a heavy chain variable region and a light chain variable region of the anti-TGF-beta1 monoclonal antibody are shown as SEQ ID NO.1 and SEQ ID NO.2. The invention further discloses a preparation method of the probiotic preparation. The probiotic preparation disclosed by the invention can effectively improve sleep quality and solve the problem of insomnia generally faced by modern people. By combining the probiotics with the anti-TGF-beta1 monoclonal antibody, the preparation not only can regulate the intestinal microecology, but also can promote sleep by influencing the nervous system, and has a remarkable improvement effect. Meanwhile, the preparation method disclosed by the invention is simple, economical and suitable for large-scale production, and has a good market application prospect.

The invention discloses a multi-modal traditional Chinese medicine insomnia differentiation method based on multi-task deep learning, which comprises the following steps: S1, collecting tongue images and clinical text symptoms of an insomnia patient, and respectively constructing a data set I and a data set II; s2, based on the data set I and the data set II, constructing and training a multi-mode traditional Chinese medicine insomnia differentiation model; and S3, inputting the standardized tongue picture image and the structured symptom vector of the patient into the multi-mode traditional Chinese medicine insomnia dialectical model to obtain a nine-classification result matched with the traditional Chinese medicine insomnia type. According to the method, tongue body segmentation, cross-modal representation construction, quality perception fusion and multi-task prediction can be automatically completed in actual deployment, and probability distribution of nine types of symptoms and a final conclusion are output on a symptom task.

The invention provides a traditional Chinese medicine composition. Compared with the prior art, the traditional Chinese medicine composition has the advantages that the traditional Chinese medicines are reasonably matched, so that all the components have the effect of synergistically improving insomnia, and uncomfortable symptoms such as exhaustion, cognitive competence impairment and irritability of insomnia patients are improved; meanwhile, a transcriptome sequencing technology is adopted, the effect of the traditional Chinese medicine composition on signal channels of patients with insomnia and mild and moderate senile dementia is analyzed and studied, and it is found that the traditional Chinese medicine composition can remarkably reverse disease-related channels on disease-related cell models, remarkably reverse insomnia disorder channels in neuronal cells and microglia cells, and remarkably reverse insomnia disorder channels in neuronal cells and microglia cells. Disorder pathways of mild and moderate senile dementia diseases are obviously reversed in neuronal cells and vascular endothelial cells; therefore, the traditional Chinese medicine composition can be used for improving insomnia and preventing and treating mild and moderate senile dementia, and the traditional Chinese medicine composition is prepared from medicinal and edible medicinal materials and is safe and reliable.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in preparation of medicines for preventing and treating stress insomnia. The composition provided by the invention is composed of vinegar-processed rhizoma cyperi, green tangerine peel, pinellia ternate, poria with hostwood, salvia miltiorrhiza, ginseng, rhizoma acori graminei, nacre mother of pearl, crude dragon bone and ginger, and the comprehensive advantages of the composition in treatment of stress insomnia are shown through a multi-target and multi-channel regulation mechanism in combination with significant regulation effects of GO function enrichment and KEGG signal channels. The multi-layer action mechanism provides a unique treatment potential for the formula, and particularly has an important clinical application prospect in the aspect of coping with complex stress response and nerve dysfunction.

The invention relates to the field of insomnia treatment, in particular to a traditional Chinese medicine composition for treating insomnia caused by upper heat, lower cold and middle-jiao deficiency, which comprises the following Chinese herbal medicines: smoked plum, processed monkshood, cassia twig, ginseng, angelica sinensis, asarum, rhizoma zingiberis, pericarpium zanthoxyli, golden cypress, coptis chinensis, bitter wine, polished round-grained rice, honey, lily, tuber fleeceflower stem, hericium erinaceus, polygala tenuifolia and poria with hostwood. The pill is prepared from a traditional Chinese medicine composition of dark plum, processed monkshood, cassia twig, ginseng, angelica sinensis, asarum, rhizoma zingiberis, pericarpium zanthoxyli, golden cypress, coptis chinensis, bitter wine, polished round-grained rice, honey, lily, tuber fleeceflower stem, hericium erinaceus, polygala tenuifolia and poria with hostwood. The traditional Chinese medicine composition can comprehensively improve insomnia symptoms caused by upper heat, lower cold and middle-jiao deficiency, and is quick in effect taking, high in safety and small in side effect.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating insomnia and a preparation method and application thereof. The traditional Chinese medicine composition for treating insomnia disclosed by the invention is derived from a classic famous prescription combination, and provides an effective prescription for solving the problem of insomnia of marine navigation personnel, so that the health guarantee ability of people such as navy long-voyage and underwater navigation officers and soldiers, marine exploration personnel, fishermen and ocean crew in China is improved.

The invention belongs to the technical field of functional preparations, and discloses a composite emulsion for improving insomnia and a preparation method thereof. The composite emulsion is prepared from the following components in percentage by volume: 70 to 95 percent of modified fucoidin solution with the concentration of 0.5 to 3 mg / mL, and the balance of melatonin-containing medium chain triglyceride, the content of the melatonin in the composite emulsion is 0.02 wt%. The compound emulsion is strong in stability and high in bioavailability, and can effectively resist an acid environment in a stomach and protect melatonin from being delivered to intestinal tracts. Through verification, the average core sleep duration of a subject taking the compound emulsion is increased by 21.05% compared with that of the subject taking melatonin only; the average waking time is shortened by 40% compared with that of melatonin, and the effect is remarkable.

A closed-loop percutaneous ear vagus nerve stimulation system acting on insomnia, the system comprising: an electrocardiogram monitor for monitoring the heart rate of a patient; the power supply module is used for supplying power to the electrocardiogram monitor; the heart rate variability sensor is used for sensing heart rate data, collecting the heart rate data and transmitting the heart rate data to the feedback controller; the feedback microcontroller is used for receiving and processing the heart rate data and identifying abnormal heart rate data generated before or during the attack of insomnia; the pulse generator is used for outputting electric pulses to the percutaneous auricular concha area vagus nerve stimulator; and the percutaneous auricular concha area vagus nerve stimulator is used for stimulating the auricular concha area vagus nerve by adopting a vagus nerve stimulating electrode.

The invention provides a formula of sleep-aiding essential oil containing cedar himalaya, relates to the technical field of sleep-aiding essential oil, and aims to solve the problems of single effect, poor stability and insufficient skin tolerance of existing sleep-aiding essential oil. The formula comprises the following components in parts by weight: 0.5-5 parts of Himalaya cedar essential oil, 80-95 parts of base oil, 1-10 parts of synergistic sleep-aiding essential oil, at least one of lavender essential oil, chamomile essential oil and sandalwood essential oil, and 0.1-1 part of optional antioxidant. During preparation, the components are ensured to be uniform through a process of stirring at a constant temperature of 25-35 DEG C and mixing at a rotating speed of 200-300rpm, the pH value of the product is 5.5-7.0, the retention rate of the active components is greater than or equal to 90% after the product is stored in a dark place at 25 DEG C for 6 months, and the use mode is that the product is smeared on wrists / necks / soles 1-2 hours before sleep, and 0.5-2mL of the product is smeared on each time. Tests show that the sleep time of insomnia people can be shortened to 15-22 min after the essential oil is continuously used for 28 days, the PSQI score is reduced by 40%-54%, the skin irritation is zero, the essential oil is suitable for preparing external sleep-aiding essential oil cream, ball bottles and other products, and a safe and efficient solution is provided for sleep disorder people.

The invention discloses a plant lactobacillus and application thereof in preparation of gamma-aminobutyric acid and improvement of sleep, and relates to the technical field of biology. According to the present invention, the plant lactobacillus XBMU-SN-23 has been preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 19, 2025, and the preservation number is CGMCC No.37118. The present invention further provides applications of the plant lactobacillus XBMU-SN-23 in gamma-aminobutyric acid preparation and sleep improvement. A metabolite of the strain XBMU-SN-23 has a sleep aiding function, and can regulate and control a neurotransmitter system to improve sleep quality by up-regulating GABA, 5-HT, IL-1 and MT, down-regulating Glu and DA and regulating protein quantity expression of a 5-HT1A receptor, a GABAAR alpha 1 receptor and a GABAAR gamma 2 receptor. Therefore, the plant lactobacillus XBMU-SN-23 has a wide application prospect in the product for preventing or treating insomnia.

The invention provides a composition of probiotics and application of the composition in treatment of insomnia. More specifically, sleep promoting peptide CSM-3 obtained through specific screening is further added into the composition, and the sleep promoting peptide can improve the activity rule of rats suffering from insomnia in an open field and can promote synthesis of 5-HIAA so as to improve sleep. After the polypeptide and probiotics are combined for use, the effect of obviously promoting the sleep increase of mice can be achieved, and the application prospect is good.

The invention belongs to the field of traditional Chinese medicine preparations, and provides a pure traditional Chinese medicine preparation for treating depression and a preparation method of the pure traditional Chinese medicine preparation. The preparation method comprises the following steps: S1, weighing raw materials according to a formula, putting the raw materials into a clean container, adding water which is 8-12 times of the total weight of the raw materials, and soaking at room temperature for 1-2 hours; s2, transferring the soaked raw materials and liquid medicine into a decoction container, boiling with strong fire, then turning into slow fire, and decocting for 1.5-2.5 hours in a slightly boiling state; according to the pure traditional Chinese medicine preparation disclosed by the invention, through reasonable compatibility of various traditional Chinese medicinal materials, all the components have a synergistic effect, and the effects of soothing liver and regulating qi, strengthening spleen and harmonizing stomach, nourishing heart and tranquilizing mind, promoting blood circulation to remove blood stasis, reducing phlegm and clearing damp are jointly achieved; the pure traditional Chinese medicine preparation can effectively improve the symptoms of low mood, restless mood, insomnia and dreaminess, inappetence and hypodynamia of depression patients, and clinical practice verifies that the pure traditional Chinese medicine preparation prepared by the invention has a remarkable effect in the aspect of treating depression compared with existing conventional anti-depression western medicines.

A transcutaneous nerve stimulation system includes a multifunctional earphone assembly that receives a sound signal from a sound source or other sources (such as a signal generator). An amplifier receiving the sound signal from the sound source or independent signal generator amplifies the sound signal to generate an amplified electrical signal. A stimulator, which includes multiple conductive electrode contacts, is coupled to the amplifier to receive the amplified electrical signal. The electrode contacts may protrude from an earbud / headphone or extend from an adjustable probe arm. The amplified electrical signal is used to apply electrical stimulation while the earphone assembly emits audible sounds according to the sound signal. The combined functionality enhances compliance with treatment regimens involving electrical stimulation of vagus nerves and other regions of a subject. Potential indications include, without limitation, major depressive disorder, epilepsy, chronic pain, pre-diabetes, insomnia, cardiovascular disorders, tinnitus, autism, daily stress, and anxiety.

The invention relates to an insomnia diagnosis and typing method based on multi-modal signal fusion, which comprises the following steps of: acquiring multi-source physiological signals of a testee during a rest period at night to construct a multi-modal information source during a sleep period; performing rhythm recognition and consistency judgment on the collected signals, calculating the rhythm change trend of each modal signal in a preset time window, and determining whether a signal fragment with physiological rhythm synchronization imbalance exists or not according to the rhythm collaboration among modals; performing inter-modal logic consistency analysis on the rhythm anomaly signal segments, identifying contradictory states of different modals in the same time window, and marking the contradictory states as modal conflict nodes; extracting an activation sequence of each modal signal according to a sequential relationship of the conflict nodes so as to determine a dominant modal of the insomnia behavior; analyzing a state transition behavior of the multi-mode signal through a sliding time window, identifying a nonlinear fracture section of a sleep state, and determining an insomnia occurrence time section and jump characteristics in combination with a mode activation sequence so as to realize insomnia diagnosis and typing judgment.

The invention relates to the field of animal model construction, in particular to a construction method and application of an insomnia zebrafish model. According to the method, a model is constructed by adopting a combined induction mode of continuous white light illumination and superposition of blue light irradiation and pentyltetrazole treatment in the period, so that rapid induction of the insomnia phenotype of the zebra fish is realized. According to the method, environment and chemical factor synergistic induction is combined, and the insomnia degree is represented through multi-dimensional indexes. The zebrafish insomnia model is successfully and stably established, and the zebrafish insomnia model can be used for screening medicines or foods for improving insomnia caused by synergistic effects of environment and chemical factors, and has the advantages of short period, comprehensive phenotype and high reproducibility.