2856results about "Drug compositions" patented technology

A recombinant humanized collagen and a preparation method therefor. The recombinant humanized type III collagen can be efficiently and stably expressed in three expression systems of yeast, Escherichia coli, and CHO cells, and has the biological activity superior to that of a commercially available collagen product. The recombinant humanized type III collagen has structural characteristics and functional activity similar to those of a natural collagen, and thus has wide application prospects in biomedical materials, tissue engineering products, cosmetics, foods, health care products or drugs, medical instruments, medical cosmetology and the like.

Compounds are provided having the following structure:or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

The invention discloses a method for improving beef quality, an action mechanism and an experimental method, in a cattle body, vitamin A can activate the expression of EBF2 through an active metabolite RA of the vitamin A, and the EBF2 can inhibit the transcription process of CYP26B1 in a targeted manner to maintain the activity of a retinol signal channel, so that PPAR gamma and downstream lipid metabolism related genes thereof are activated, and the activity of the retinol signal channel is improved. Fatty acid transport and lipid accumulation in fat cells in the cattle muscle are promoted, fat deposition in the cattle muscle is promoted, and the beef quality is improved. By constructing the molecular network for regulating and controlling the formation of the fat in the cattle muscle, a complex regulation and control mechanism for controlling the fat deposition in the cattle muscle can be understood more deeply, a method for improving the beef quality based on regulating and controlling the vitamin A mediated key factor EBF2 is provided, and a new way is provided for improving the beef quality in a targeted manner.

The invention relates to compositions (e.g., pharmaceutical compositions), uses, methods, non-therapeutic and therapeutic methods related to senolytic agents encapsulated or comprised in Muse cell derived extracellular vesicles (e.g. exosomes). Such compositions and methods are useful for specifically killing senescent cells and reverting any symptoms, disorders or diseases associated with senescence.

Telomerase reverse transcriptase (TERT) expression enhancing isoxazole-3-carboxamide compounds, and methods for using the same, are provided. These compounds and methods find use in a variety of applications in which increased expression of telomerase reverse transcriptase is desired.

Compounds having the structure of Formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof; wherein R1, R2, R3, R4, R5, L1, L2, a and z are as defined herein, are disclosed. Use of these compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds, and methods for their use and preparation are also provided.

Provided herein, inter alia, is an engineered non-plant cell that produces a hyoscyamine alkaloid product, a precursor of a hyoscyamine alkaloid product, or a derivative of a hyoscyamine alkaloid product. Also described is a method for producing a scopolamine alkaloid, a precursor of a scopolamine alkaloid product, or a derivative of a scopolamine alkaloid product using a cell.

The invention discloses a pharmaceutical composition for promoting angiogenesis and tissue regeneration and application thereof. The pharmaceutical composition of the present invention comprises an acidic secretory protein rich in cysteine, a disaccharide chain proteoglycan, and an XV-type collagen alpha1 chain. The biological material system loaded with the three types of proteins can promote angiogenesis, and can improve the tissue regeneration efficiency of bone, cartilage and skin defect areas.

To provide a simple method for producing a fluorinated pyrimidone compound that offers potential for diverse derivatization as an intermediate for pharmaceuticals or agrochemicals.SOLUTION: A method for producing a fluorinated pyrimidone compound comprises a step of preparing a fluorinated pyrimidone compound represented by general formula (3) through the reaction of a hexafluoroisobutyric acid ester represented by general formula (1) with an amidinopyridine represented by general formula (2).SELECTED DRAWING: None

Provided herein is a class of ionizable lipid compounds represented by formula (IV), or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

There is provided an oligonucleotide or a pharmaceutically acceptable salt thereof with a novel chemical modification pattern, which has a RNA interfering action and / or a gene expression suppressing action. A sense strand region has a specific modification pattern with a 3'-modified nucleoside, and an antisense strand region has, in a specific region, a modification pattern in which DNA, RNA, 2'-O,4'-C-bridging-modified nucleosides, 2'-MOE RNA or the like are appropriately combined.

The invention relates to the technical field of RNA interference, and particularly discloses an RNA interference fragment of a crustacean hyperglycemia hormone gene and application of the RNA interference fragment. The RNA interference fragment provided by the invention is injected into a third step foot of a river crab in an injection manner and is used for interfering the mRNA expression quantity of a hyperglycemia hormone gene CHH of a crustacean of the river crab. The fighting behavior of the eriocheir sinensis is effectively controlled, the yield in large-scale breeding of the eriocheir sinensis is improved, and economic losses caused by incomplete crabs due to fighting of the eriocheir sinensis are reduced.

The present invention relates to mitochondrial-targeted agents and their utility in increasing telomere length and / or suppressing telomere shortening.

Provided is a compound represented by formula (I) or a salt thereof. In formula (I), A represents a single bond or a substituted or unsubstituted divalent aromatic hydrocarbon group, L represents a substituted or unsubstituted linear or branched chain alkylene group having 1-13 carbon atoms, X represents a group represented by -(CH2CH2O)s-, -(CH2CH2CH2O)s-, -(CH(CH3)CH2O)s-, or -(CH2)tO-, s represents a number of 1-8, and t represents a number of 2-10.

The invention discloses an electrotransfection buffer solution and application of the electrotransfection buffer solution in exosome loaded polypeptide, and relates to the technical field of biology. The electrotransfection buffer solution is prepared from the following components: 80 to 120 mM of trehalose, 6 to 10 mM of dipotassium phosphate, 12 to 16 percent of iodixanol and a buffer solution. The invention also provides a method for carrying out exosome drug loading by using the electrotransfection buffer solution, more efficient loading of palmitoyl pentapeptide-4 by the exosome is realized, the loading capacity of molecules is improved on the premise of not losing the exosome, a higher collagen expression level can be obtained, and the method disclosed by the invention can be applied to large-scale and large-scale production. And the subsequent yield requirement is met.

To provide a hybrid liposome exosome that can deliver an active component with a higher concentration to target cells, and the like. According to a peptide-binding hybrid liposome exosome comprising in a lipid bilayer an exosome marker protein selected from CD63, CD81, and CD9 and peptide-binding lipid derivatives in which a peptide binds to a hydrophilic part of a complex lipid, it is possible to impart an additional function regarding endosome release from the peptide-binding hybrid liposome exosome after being incorporated into endosomes of target cells, and thereby it is possible to provide a carrier for a drug delivery system that can deliver an active component with a higher concentration into target cells.

The present invention relates to a preparation of Combretum micranthum G. Don for use in human or animal subjects for the treatment and / or prevention of pain. The present invention further relates to a pharmaceutical or non-pharmaceutical composition containing a preparation of Combretum micranthum G. Don according to the invention, for use in human or animal subjects for the treatment and / or prevention of pain.

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.

Disclosed herein are a peptoid compound and a peptoid conjugate such as a peptoid-lipid conjugate, and preparation methods therefor and the use thereof in a small molecule drug and nucleic acid delivery. Further disclosed herein are a lipid particle containing the peptoid-lipid conjugate, such as a liposome and a lipid nanoparticle, and a small molecule drug and / or a nucleic acid delivery composition containing the peptoid-lipid conjugate or the lipid particle. The peptoid-lipid conjugate, lipid particle, and small molecule drug and / or nucleic acid delivery composition that can be used for the small molecule drug and nucleic acid delivery of the present invention enable highly efficient compounding, protection, intracellular and targeted delivery and release of the small molecule drug and biomolecules, such as nucleic acids, in tissues and organs both in vitro and in vivo.

The invention relates to the technical field of genetic engineering, in particular to recombinant humanized collagen and a preparation method thereof. The recombinant humanized III-type collagen provided by the invention can be efficiently and stably expressed under three expression systems of yeast, escherichia coli and CHO cells, and has biological activity superior to that of commercially available collagen products. The recombinant humanized III-type collagen disclosed by the invention has structural characteristics and functional activity similar to those of natural collagen, so that the recombinant humanized III-type collagen has wide application prospects in the aspects of biomedical materials, tissue engineering products, cosmetics, foods, health care products or medicines, medical instruments, medical cosmetology and the like.

The present invention relates generally to novel mixtures of (2E)-3-(1, 3-benzodioxol-5-yl)-N-phenyl-N-(tetrahydro-3-furyl)-2-acrylamide and to the use thereof.

A drug delivery platform providing flexible fine tune of cell therapy is disclosed herein. Particularly, an engineered fusion protein is coupled with a high affinity ligand carrying at least one payload of drug to be internalized by the transplanted cell to observe or regulate transplanted cell therapy effects.

To provide a novel autophagy derivative.SOLUTION: The autophagy derivative contains Equisetum arvense L. and / or Ligustrum Lucidum Aiton.SELECTED DRAWING: None

This autophagy activator contains at least one of compounds represented by any one of structural formulas (1)-(6).

Compositions and methods for editing, e.g., introducing double-stranded breaks, within the KLKB1 gene are provided. Compositions and methods for treating subjects having hereditary angioedema (HAE), are provided.

The invention belongs to the technical field of health-care food, and particularly relates to a medicinal and edible tea substitute beverage for relieving summer-heat and resolving dampness as well as a preparation method and application thereof, and the medicinal and edible tea substitute beverage is prepared from the following raw materials in parts by weight: 3-20 parts of agastache rugosus, 2-20 parts of elsholtzia, 5-30 parts of codonopsis pilosula and 1-15 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition adopts a traditional Chinese medicine syndrome differentiation and treatment method to dispel summer heat, relieve exterior syndrome, resolve dampness with aromatics, regulate qi and strengthen the middle warmer, and can well improve or relieve the heatstroke symptom of subjects.

To provide crystals of dihydrosphingomyelin with a reduced water content, and a production method that enables the production of the crystals of dihydrosphingomyelin with a reduced water content.SOLUTION: The present invention provides a crystal of dihydrosphingomyelin represented by the following formula (1), having peaks at diffraction angles (2θ)=3.3±0.2°, 4.9±0.2°, 6.6±0.2°, 10.0±0.2°, 13.4±0.2°, 16.8±0.2°, 18.5±0.2°, 20.2±0.2°, 21.9±0.2°, and 23.7±0.2° in powder X-ray diffraction.SELECTED DRAWING: None

Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.

The invention provides a novel compound for targeted delivery of an oligonucleotide drug and a conjugate combined with the oligonucleotide drug, the novel compound can deliver one or more different oligonucleotide drugs, and the compound has a structure shown as a formula (I), a formula (II) or a formula (III). # imgabs0 #