10 results about "Vasoactive" patented technology

The invention relates to a chitosan oligosaccharide-gallic acid carbon dot engineered exosome and a preparation method and application thereof.The preparation method comprises the steps that firstly, chitosan oligosaccharide-gallic acid composite carbon dots (COS / GA-CDs) are synthesized in one step through a hydrothermal method, the COS / GA-CDs engineered exosome (COS / GA-CDs (at) EVs) is constructed by means of the electrostatic self-assembly effect of surface positive charges of the COS / GA-CDs and exosome membrane negative charges, and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs are subjected to According to the exosome disclosed by the invention, the inherent vasoactive substances of the exosome are reserved, the antioxidant / anti-inflammatory function and the endothelial cell uptake enhancement effect are given through carbon dot synergism, and the problems that the natural exosome is limited in biological activity, insufficient in stability and low in cell uptake efficiency are solved.

The invention belongs to the technical field of biological medicine, and particularly relates to a noninvasive controllable flexible biological electronic patch for treating diabetic erectile dysfunction. The erectile dysfunction related to diabetes is difficult to recover due to long-term damage of a cavernous body microenvironment, traditional oral administration or cavernous body injection treatment has poor targeting, non-uniform distribution and complication risk, and long-term curative effect is difficult to realize. The invention provides a flexible and attachable bioelectronic patch which is used for noninvasively, painlessly and controllably adjusting an erectile tissue microenvironment. The device synergistically promotes local vascular active factor expression and endothelial repair through mild electrical stimulation, realizes uniform transdermal delivery of drug molecules, shows high delivery efficiency and cell activity, and significantly improves cavernous body blood flow and cell functions. In an in-vitro cell model and a diabetic animal model, the device shows better vascular regeneration and function recovery effects than traditional medicine or injection therapy.

To provide a technique for measuring cerebrovascular reactivity.SOLUTION: A method for quantitative measurement of cerebrovascular reactivity (CVR) combines sequential gas delivery with Δ R2 * - based perfusion analysis. The sequential gas delivery imposes a first staged reoxygenation 304 after a first hypoxia 302 and a second staged reoxygenation 310 after a second hypoxia 308. MRI gradient echo imaging records the Δ R2 * time course in the target voxel during each reoxygenation. The sigmoid fit yields perfusion indices including relative cerebral blood flow, relative cerebral blood volume, and mean transit time. Comparison of indices derived from two re-oxygenation sessions yields numerical CVR values that are reproducible between sessions and subjects.SELECTED DRAWING: Figure 3

This invention relates to a method for preparing a mineralized fiber scaffold composite injectable macroporous hydrogel that mimics natural bone emulsion (ECM). The method proposes preparing a PBLG fiber scaffold using electrospinning, gas foaming, and in-situ mineralization. Subsequently, the mineralized fiber scaffold composite injectable macroporous hydrogel is constructed through negative pressure perfusion, mechanical fragmentation, and gel fragmentation and reorganization. The mineralized fiber scaffold composite injectable macroporous hydrogel prepared by this invention can adapt to irregular bone defect areas, providing temporary support after implantation and offering excellent osteogenic induction and angiogenic activity for subsequent bone defect repair. The macroporous structure formed by microgel reorganization also supports the ingrowth of new tissue. This material has promising applications in bone defect repair and can also be extended to other medical fields such as cartilage defect repair and drug delivery.

The present invention relates to the polyherbal composition for optimum vascular activity and cardiac health. The Invention also provides its method of preparation. The composition exhibits beneficial effects in regulating dyslipidaemia, controlling and reducing arterial fat deposition along with reducing elevated levels of serum cholesterol, triglycerides and associated atherosclerosis. The composition also regulates lipid levels and promotes cardiovascular health, as well as improves overall cardiac function.

This invention discloses a bilayer hydrogel scaffold, its preparation method, and its applications, relating to the field of medical repair materials technology. The bilayer hydrogel scaffold comprises upper and lower hydrogel layers made of materials with different degradation rates and mechanical properties, both layers being loaded with nano-fat emulsions. The thickness of the upper hydrogel layer is greater than or equal to the thickness of the lower hydrogel layer. This invention utilizes the differences in degradation rates and mechanical properties of different materials to prepare a bilayer hydrogel scaffold, integrating functions such as promoting nerve repair, promoting vascular activity, and promoting bone activity. It achieves the effect of simultaneously adapting to two different pathological environments within the same implant, thereby avoiding secondary surgery for patients. This invention utilizes photocrosslinking technology to achieve integrated molding of the bilayer structure, ensuring a strong interface bond between the upper and lower layers and eliminating the risk of delamination. Simultaneously, the preparation process is controllable and highly customizable, allowing for flexible adjustment of the scaffold's size and pore structure according to the clinical defect morphology.

The invention discloses a multi-mode invasive pressure sensor based on embedded artificial intelligence induction, and relates to the technical field of medical instruments, the multi-mode invasive pressure sensor comprises a sensor shell, a multi-mode sensing array and a fluid channel communicated with the multi-mode sensing array are integrated in the sensor shell, and a micro pump is arranged at the inlet end of the fluid channel; the system further comprises an embedded manual processing system. By providing an integrated architecture of a multi-modal sensing array and embedded AI processing, an embedded AI algorithm recognizes and corrects waveform distortion caused by over-damping and under-damping in real time, it is ensured that reading of systolic pressure and diastolic pressure accurately reflects real physiological values, the pressure measurement error is reduced, the precision is improved, and the measurement accuracy is improved. According to the present invention, the clinical high precision requirement on the vasoactive drug titration is met, the automatic diagnosis can be performed, the optimal dynamic response state can be rapidly adjusted, the sensor is particularly suitable for the time-sensitive emergency and operation environment, the sensor has the high overall waterproof grade, the clinical routine disinfection can be tolerated, and the service life meets the disposable use requirement.

The present application relates to the technical field of computer information processing, in particular to a dynamic adjustment method of intensive care parameters based on reinforcement learning. The scheme comprises: obtaining patient respiratory mechanics parameter data and continuous invasive arterial blood pressure waveform data; generating a mechanics context vector representing the real-time influence mode and intensity of respiratory mechanics on blood pressure through a mechanics context encoder based on a dual-channel neural network with attention mechanism; inputting the vector and the patient physiological state feature vector into a reinforcement learning agent after concatenation, and outputting an adjustment action of vasoactive drug infusion rate to control the infusion pump to execute; the reward function of the reinforcement learning agent adopts a dynamic target blood pressure value as a reference which decreases with the increase of positive end-expiratory pressure. The method is mainly used for closed-loop automatic adjustment of vasoactive drugs for mechanically ventilated patients in intensive care, to suppress non-pharmacological interference and avoid excessive drug administration.

A method for evaluating the response of the vascular endothelium of a human subject to a stimulus, by observing the reaction of the endothelium before and after the topical application of a vasoactive substance, before and after application of the stimulus. The observation is carried out by at least one camera device, which may be a high-resolution spectrophotometric, THz, infrared, ultraviolet optical coherence tomography, or optical elasticity camera, which device is used to observe a skin area or areas of the subject. One device may take the measurements of the area of skin before and after topical application of a vasocative substance, or two devices may be used contemporaneously to each measure an area of skin with and without the topical substance. The device may be applied to the skin, or remote from the skin, or implanted in or under the skin.

The invention discloses an intelligent vasoactive drug closed-loop infusion system for a cardiac surgery ICU, and relates to the technical field of medical equipment and control, in particular to the intelligent vasoactive drug closed-loop infusion system for the cardiac surgery ICU, which comprises a multi-channel physiological signal acquisition unit for continuously acquiring blood pressure and heart rate signals of a patient, and the central processing and control unit is internally provided with a medicine regulation and control logic module. The regulation and control module automatically generates a control instruction without delay based on comparison between the real-time physiological signal and a preset target range, and directly drives the medicine infusion execution unit to adjust the infusion rate. The system further comprises a safety boundary monitoring unit and a nursing record synchronization interface, so that treatment safety and data synchronization are ensured. Besides, the system can integrate third-party monitoring equipment data, supports multi-drug collaborative management and AI-based individualized target dynamic setting, and realizes intelligent and automatic closed-loop accurate regulation and control of vasoactive drug infusion of critical patients.