15 results about "Vasoactive" patented technology

The invention relates to a chitosan oligosaccharide-gallic acid carbon dot engineered exosome and a preparation method and application thereof.The preparation method comprises the steps that firstly, chitosan oligosaccharide-gallic acid composite carbon dots (COS / GA-CDs) are synthesized in one step through a hydrothermal method, the COS / GA-CDs engineered exosome (COS / GA-CDs (at) EVs) is constructed by means of the electrostatic self-assembly effect of surface positive charges of the COS / GA-CDs and exosome membrane negative charges, and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs and the COS / GA-CDs (at) EVs are subjected to According to the exosome disclosed by the invention, the inherent vasoactive substances of the exosome are reserved, the antioxidant / anti-inflammatory function and the endothelial cell uptake enhancement effect are given through carbon dot synergism, and the problems that the natural exosome is limited in biological activity, insufficient in stability and low in cell uptake efficiency are solved.

The invention provides an intelligent optimization method and system for personalized intraoperative blood pressure management, and relates to the technical field of intraoperative monitoring. The method comprises the following steps: continuously collecting multi-modal real-time physiological data for describing the circulation state of a patient in an operation process; based on the multi-modal real-time physiological data, constructing a state vector reflecting individual haemodynamics; inputting the state vector into a blood pressure optimization decision model subjected to offline pre-training and online self-adaption to obtain a regulation and control instruction aiming at the vasoactive medicine and / or infusion; adjusting the administration or infusion rate through an execution mechanism according to the regulation and control instruction; and updating the state vector according to the multi-modal real-time physiological data obtained after adjustment, and adaptively correcting the blood pressure optimization decision model to form closed-loop optimization control. According to the invention, the precision, the adaptability and the safety of intraoperative blood pressure control can be obviously improved, and the method has a good clinical application prospect and expansibility.

The invention relates to a polyamino acid electrostatic spinning mineralization bracket with a hierarchical pore structure and a preparation method thereof. A three-dimensional PBLG electrostatic spinning fiber scaffold is prepared through a gas foaming method, and the structural stability of the three-dimensional scaffold is remarkably improved through welding and subsequent in-situ mineralization in a CH2Cl2 steam atmosphere. The prepared bionic fiber scaffold can play a temporary supporting role after being implanted into a defect area, good osteogenesis induction and angiogenesis activity are provided for subsequent bone defect repair, a pore structure formed through foaming can also support ingrowth of new tissues, and the scaffold has good application prospects in the field of bone defect repair and is suitable for popularization and application in the field of bone defect repair. The method can also be expanded to the medical fields of hemostasis, drug delivery and the like.

The invention belongs to the technical field of biological medicine, and particularly relates to a noninvasive controllable flexible biological electronic patch for treating diabetic erectile dysfunction. The erectile dysfunction related to diabetes is difficult to recover due to long-term damage of a cavernous body microenvironment, traditional oral administration or cavernous body injection treatment has poor targeting, non-uniform distribution and complication risk, and long-term curative effect is difficult to realize. The invention provides a flexible and attachable bioelectronic patch which is used for noninvasively, painlessly and controllably adjusting an erectile tissue microenvironment. The device synergistically promotes local vascular active factor expression and endothelial repair through mild electrical stimulation, realizes uniform transdermal delivery of drug molecules, shows high delivery efficiency and cell activity, and significantly improves cavernous body blood flow and cell functions. In an in-vitro cell model and a diabetic animal model, the device shows better vascular regeneration and function recovery effects than traditional medicine or injection therapy.

The application discloses a kind of nano composite hydrogel dressings with reversible adhesion-photothermal sterilization function and preparation method thereof.The preparation method includes the following:1) preparation of metal organic framework ZIF-8, which is immersed in a solution containing cyanidin CY-7 to achieve drug adsorption;DA is then used to coat the surface of the obtained sample to obtain ZIF-8 / CY-7 / PDA particles;2) preparation of 7-carboxymethoxyl-4-methyl coumarin CM with carboxyl at the end;3) through EDC coupling reaction, CM is grafted onto the side chain of dopamine-modified chitosan molecules to obtain CS-DA-CM;4) disperse ZIF-8 / CY-7 / PDA particles and angiogenic components in CS-DA-CM solution to obtain the dressing.The dressing can be injected and used, and can be gelled in situ to achieve adhesion when irradiated with a light source with a wavelength greater than 300 nm, and can be converted back to a solution when irradiated with a light source with a wavelength less than 280 nm;when an infrared wavelength with a wavelength of 820 nm is used, photothermal effect can be excited to achieve photothermal sterilization at the wound site, and photothermal effect can promote blood flow to accelerate wound healing.

The invention discloses an intraoperative hypotension advanced early warning and vasoactive drug automatic titration method. The method comprises the steps that S1, multi-mode physiological signal collection, conveying and time synchronization are conducted on a patient in an operation; s2, performing real-time hypotension prediction based on the multi-head attention network, and outputting three predicted values: a hypotension risk probability, an average arterial pressure predicted value and a short-term average arterial pressure change rate; judging whether to step into a hypotension risk interval and early warning; s3, automatic titration of the closed-loop vasoactive drug: S3.1, closed-loop triggering or exiting is realized according to different conditions; s3.2, performing medicine titration rate increment calculation in a closed-loop mode; and S3.3, carrying out automatic titration and safety protection on the vasoactive drug according to the increment of the drug titration rate. Real-time operation and advanced early warning of the model end side are achieved, a prediction result and vasoactive drug titration form a closed loop, and the system is suitable for various surgical operation scenes needing fine blood pressure management.

To provide a technique for measuring cerebrovascular reactivity.SOLUTION: A method for quantitative measurement of cerebrovascular reactivity (CVR) combines sequential gas delivery with Δ R2 * - based perfusion analysis. The sequential gas delivery imposes a first staged reoxygenation 304 after a first hypoxia 302 and a second staged reoxygenation 310 after a second hypoxia 308. MRI gradient echo imaging records the Δ R2 * time course in the target voxel during each reoxygenation. The sigmoid fit yields perfusion indices including relative cerebral blood flow, relative cerebral blood volume, and mean transit time. Comparison of indices derived from two re-oxygenation sessions yields numerical CVR values that are reproducible between sessions and subjects.SELECTED DRAWING: Figure 3

This invention relates to a method for preparing a mineralized fiber scaffold composite injectable macroporous hydrogel that mimics natural bone emulsion (ECM). The method proposes preparing a PBLG fiber scaffold using electrospinning, gas foaming, and in-situ mineralization. Subsequently, the mineralized fiber scaffold composite injectable macroporous hydrogel is constructed through negative pressure perfusion, mechanical fragmentation, and gel fragmentation and reorganization. The mineralized fiber scaffold composite injectable macroporous hydrogel prepared by this invention can adapt to irregular bone defect areas, providing temporary support after implantation and offering excellent osteogenic induction and angiogenic activity for subsequent bone defect repair. The macroporous structure formed by microgel reorganization also supports the ingrowth of new tissue. This material has promising applications in bone defect repair and can also be extended to other medical fields such as cartilage defect repair and drug delivery.

The present invention relates to the polyherbal composition for optimum vascular activity and cardiac health. The Invention also provides its method of preparation. The composition exhibits beneficial effects in regulating dyslipidaemia, controlling and reducing arterial fat deposition along with reducing elevated levels of serum cholesterol, triglycerides and associated atherosclerosis. The composition also regulates lipid levels and promotes cardiovascular health, as well as improves overall cardiac function.

The invention relates to the technical field of intensive care medical treatment, and discloses a vasoactive drug intelligent infusion system based on real-time physiological data. A physiological data acquisition unit of the system acquires real-time physiological data and performs preprocessing. The physiological state classification unit classifies the preprocessed data according to a preset physiological state interval, and extracts multiple types of physiological features to generate a state feature set. The abnormal state marking unit monitors the switching frequency of the physiological state interval and marks the abnormal state interval when the frequency exceeds a threshold value. The drug reaction feature decomposition unit decomposes the feature set of the non-abnormal state interval based on the similarity between the historical drug reaction stage and the current physiological feature to generate a drug reaction feature subset. And the physiological parameter coupling correction unit is used for performing parameter correction on the subset by utilizing the coupling relationship among the physiological parameters. And the medicine infusion decision-making unit reversely traverses and positions potential medicine requirements along the medicine effect path, and accordingly, the infusion priority is determined, and an infusion instruction is generated.

This invention discloses a bilayer hydrogel scaffold, its preparation method, and its applications, relating to the field of medical repair materials technology. The bilayer hydrogel scaffold comprises upper and lower hydrogel layers made of materials with different degradation rates and mechanical properties, both layers being loaded with nano-fat emulsions. The thickness of the upper hydrogel layer is greater than or equal to the thickness of the lower hydrogel layer. This invention utilizes the differences in degradation rates and mechanical properties of different materials to prepare a bilayer hydrogel scaffold, integrating functions such as promoting nerve repair, promoting vascular activity, and promoting bone activity. It achieves the effect of simultaneously adapting to two different pathological environments within the same implant, thereby avoiding secondary surgery for patients. This invention utilizes photocrosslinking technology to achieve integrated molding of the bilayer structure, ensuring a strong interface bond between the upper and lower layers and eliminating the risk of delamination. Simultaneously, the preparation process is controllable and highly customizable, allowing for flexible adjustment of the scaffold's size and pore structure according to the clinical defect morphology.

The invention discloses a multi-mode invasive pressure sensor based on embedded artificial intelligence induction, and relates to the technical field of medical instruments, the multi-mode invasive pressure sensor comprises a sensor shell, a multi-mode sensing array and a fluid channel communicated with the multi-mode sensing array are integrated in the sensor shell, and a micro pump is arranged at the inlet end of the fluid channel; the system further comprises an embedded manual processing system. By providing an integrated architecture of a multi-modal sensing array and embedded AI processing, an embedded AI algorithm recognizes and corrects waveform distortion caused by over-damping and under-damping in real time, it is ensured that reading of systolic pressure and diastolic pressure accurately reflects real physiological values, the pressure measurement error is reduced, the precision is improved, and the measurement accuracy is improved. According to the present invention, the clinical high precision requirement on the vasoactive drug titration is met, the automatic diagnosis can be performed, the optimal dynamic response state can be rapidly adjusted, the sensor is particularly suitable for the time-sensitive emergency and operation environment, the sensor has the high overall waterproof grade, the clinical routine disinfection can be tolerated, and the service life meets the disposable use requirement.

The present application relates to the technical field of computer information processing, in particular to a dynamic adjustment method of intensive care parameters based on reinforcement learning. The scheme comprises: obtaining patient respiratory mechanics parameter data and continuous invasive arterial blood pressure waveform data; generating a mechanics context vector representing the real-time influence mode and intensity of respiratory mechanics on blood pressure through a mechanics context encoder based on a dual-channel neural network with attention mechanism; inputting the vector and the patient physiological state feature vector into a reinforcement learning agent after concatenation, and outputting an adjustment action of vasoactive drug infusion rate to control the infusion pump to execute; the reward function of the reinforcement learning agent adopts a dynamic target blood pressure value as a reference which decreases with the increase of positive end-expiratory pressure. The method is mainly used for closed-loop automatic adjustment of vasoactive drugs for mechanically ventilated patients in intensive care, to suppress non-pharmacological interference and avoid excessive drug administration.

A method for evaluating the response of the vascular endothelium of a human subject to a stimulus, by observing the reaction of the endothelium before and after the topical application of a vasoactive substance, before and after application of the stimulus. The observation is carried out by at least one camera device, which may be a high-resolution spectrophotometric, THz, infrared, ultraviolet optical coherence tomography, or optical elasticity camera, which device is used to observe a skin area or areas of the subject. One device may take the measurements of the area of skin before and after topical application of a vasocative substance, or two devices may be used contemporaneously to each measure an area of skin with and without the topical substance. The device may be applied to the skin, or remote from the skin, or implanted in or under the skin.

The invention discloses an intelligent vasoactive drug closed-loop infusion system for a cardiac surgery ICU, and relates to the technical field of medical equipment and control, in particular to the intelligent vasoactive drug closed-loop infusion system for the cardiac surgery ICU, which comprises a multi-channel physiological signal acquisition unit for continuously acquiring blood pressure and heart rate signals of a patient, and the central processing and control unit is internally provided with a medicine regulation and control logic module. The regulation and control module automatically generates a control instruction without delay based on comparison between the real-time physiological signal and a preset target range, and directly drives the medicine infusion execution unit to adjust the infusion rate. The system further comprises a safety boundary monitoring unit and a nursing record synchronization interface, so that treatment safety and data synchronization are ensured. Besides, the system can integrate third-party monitoring equipment data, supports multi-drug collaborative management and AI-based individualized target dynamic setting, and realizes intelligent and automatic closed-loop accurate regulation and control of vasoactive drug infusion of critical patients.