45 results about "Nerve Blockade" patented technology

A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled release material to obtain a. reversible nerve blockade or anesthesia effect when implanted or injected in a patient, and a non-toxic glucocorticosteroid agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the glucocorticosteroid agent.

A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluding implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.

An apparatus for locating and anesthetizing a nerve enables an anesthesiologist to perform a nerve blockade procedure without an assistant. An anesthetic-filled syringe is releasably mounted to a hands-free, foot-actuated, hydraulic syringe controller. An electric current generator is mounted to the syringe controller and operatively connected to a needle of the syringe. A hands-free, foot-actuated current generator controller determines an amperage of an electrical stimulus output to the needle. The current generator includes audible and visual displays for informing the anesthesiologist of the output amperage. Because the syringe controller and current generator controller allow hands-free operation, an anesthesiologist can continuously use both hands to manipulate and hold the needle in a patient.

Methods and formulations for inducing substantially safer local anesthesia in a patient are provided. The methods comprise administering, to a patient in need thereof, a substrate containing a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material to safely obtain a reversible nerve blockade when implanted or injected in a patient.

The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester anesthetics and mixtures thereof, the at least one drug substance being substantially homogeneously dispersed in the collagen matrix, and the at least one drug substance being present in an amount sufficient to provide a duration of local analgesia, local anesthesia or nerve blockade which lasts for at least about one day after administration.

The invention discloses a handheld ultrasonic guidance nerve block robot, which comprises a clamping mechanism used for clamping an ultrasonic probe, a straight line position regulation mechanism, anarc line posture adjustment mechanism, a radial movement puncture end and a puncture control system, wherein the clamping mechanism, the straight line position regulation mechanism, the arc line posture adjustment mechanism, the radial movement puncture end and the puncture control system are connected in sequence; and the puncture control system is independently connected with the clamping mechanism, the straight line position regulation mechanism, the arc line posture adjustment mechanism and the puncture end to output a control instruction. The handheld ultrasonic image guidance nerve blockrobot with a light structure is used for assisting a doctor in finishing high-accuracy nerve block.

The invention discloses an application of an N-acetanilide cationic compound in preparation of a local nerve blocking drug. The cationic compound is a quaternary ammonium salt compound and has a structure as shown in a formula (I), wherein X is a halogen atom. When used alone, the compound has the characteristics of good safety performance, strong nerve blocking effect and the like, can take a reversible and durable local anaesthesia effect in vivo and can be used as a local anaesthesia drug or an analgesic drug which is long-acting and / or capable of realizing selective blocking. Particularly, a composition composed of the compound and other local anaesthesia drugs has the remarkable characteristics of high effect taking speed, strong effect, long acting time, little nerve injury and the like when used for nerve blocking.

Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the “caine” classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).

An apparatus for performing a nerve block procedure, the apparatus being composed of an echogenic needle or an echogenic soft tissue tunneling device and an echogenic catheter configured for controlled delivery of a medication. The apparatus may further include a sheath such that at least one of the needle or tunneling device and sheath is echogenic. The present invention also encompasses a system for performing a nerve block procedure, the system includes introducing an echogenic needle in the general area of a nerve bundle, positioning the echogenic needle adjacent the nerve bundle utilizing sonic imaging techniques, introducing an echogenic catheter configured for controlled delivery of a fluid through the echogenic needle, withdrawing the echogenic needle, positioning the echogenic catheter adjacent the nerve bundle utilizing sonic imaging techniques, and delivering fluid to the nerve bundle through the echogenic catheter.

An endoscopic procedure for the parasympathetic and sympathetic denervation of the nerves of the ovaries and uterus for management of endocrine dysphoric disorders. The tissues of selected inferior mesenteric and pelvic nerves are heated via introduction of radiofrequency energy at sufficient power and time to induce complete or partial nerve blockade while leaving the supporting tissue structurally intact. In some embodiments, the suspensory ligament of the ovary, the ovarian ligament, and / or the uterosacral ligament are heated to a range of 45° C. to 65° C. for a period of about 5 seconds to about 60 seconds.

A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

Provided herein is a method of blocking a nerve or neuron by applying an electrical stimulation to the nerve or neuron, wherein the electrical stimulation is of an intensity below the excitation threshold of the nerve or neuron for a length of time sufficient to produce a block of nerve conduction or neuron excitation.

The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester anesthetics and mixtures thereof, the at least one drug substance being substantially homogeneously dispersed in the collagen matrix, and the at least one drug substance being present in an amount sufficient to provide a duration of local analgesia, local anesthesia or nerve blockade which lasts for at least about one day after administration.

A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

The invention discloses a nerve block anesthesia medicine injection pressure measurement alarm device under ultrasound. The device comprises an injector, a pressure sensor, a constraint unit and a mounting base; a nerve block puncture needle is connected to a liquid medicine outlet of the injector through a three-way joint; the pressure sensor is connected with the three-way joint through a connecting mechanism; a single-chip microcomputer and an alarm unit are installed on the side face of the mounting base, a power source is arranged in the mounting base, and the single-chip microcomputer iselectrically connected with the pressure sensor through a telescopic cable; the binding unit comprises a hinge and binding belts; the binding belt is hinged to the mounting base through hinges, the two binding belts are symmetrically arranged up and down, and the ends of the two binding belts are connected through an inserting unit.The nerve block anesthesia medicine injection pressure measurement alarm device is good in use flexibility, convenient to use in the field, high in practicability and convenient to carry.

The invention provides an ultrasound-guided nerve block puncture needle, which can enhance ultrasonic reflection and further clearly image. The nerve block puncture needle comprises a needle tip guiding area, a needle body, a needle base, an extension tube and a needle tail, wherein the needle tip guiding area comprises a puncture end and a guiding part, and a plurality of annular grooves arranged in a linear mode are formed in the shallow surface layer of the tube wall of the guiding part. The puncture needle has remarkably improved ultrasound reflection and clearer developing effects, and the safety and the effectiveness during puncture are effectively improved.

A catheter system includes a medication dispenser located external to a patient. A subcutaneous port displaced internal to the patient and receives a quantity of medication. The port can be filled from the medication dispenser using a Huber needle, or some other suitable needle, fluidically connected to the medication dispenser by tubing. The catheter can be placed in proximity to a patient's nervous system using ultrasound imaging guidance. A method of administering a nerve block to a patient includes the steps of placing a subcutaneous port using ultrasound imaging for guidance and administering medication via a catheter connected to the port.

The invention provides a foot pump type injection pump special for nerve block under ultrasonic guidance, which comprises foot pumps and an injection structure, the injection structure drives a needle cylinder to push or withdraw through the cooperation of a sealing cavity and hydraulic pressure, the number of the foot pumps is two, the two foot pumps respectively pressurize and depressurize the injection structure, and the two foot pumps correspond to the push and withdraw actions of an injector; according to the device, an assistant is not needed, operation is completed by one person independently, ultrasonic nerve positioning and puncture operation are carried out through the two hands respectively, meanwhile, liquid medicine injection and withdrawing are carried out through the action that the foot treads or lifts the pedal, and the work content of a second person is omitted; the size is small, the cost is low, and electronic equipment is not needed.

The invention discloses an angle-adjustable ultrasound-guided nerve block puncture positioning device, which includes a fixing plate, an installation seat is arranged on the left side of the fixing plate, and an ultrasonic probe is arranged on the left side of the installation seat. The front of the fixed plate is fixedly connected with a fixed column, the front of the fixed column is fixedly connected with a fixed ring, the back side of the fixed ring is fixedly connected with a bracket, the inner side of the fixed ring is fixedly connected with a fixed gear, and the fixed plate The back side of the motor is fixedly connected with a motor, the top of the fixed plate is provided with a control switch electrically connected with the motor, the front key of the motor is connected with a rotating shaft, and the outer side of the rotating shaft is fixedly connected with a driving gear. The ultrasound-guided nerve block puncture positioning device has a novel structure and an ingenious conception, and can freely adjust different angles of the puncture head during puncture, so as to improve the accuracy of the needle insertion angle of the puncture head and improve the puncture quality.

Anesthetics covalently conjugated onto biodegradable and biocompatible hydrophilic polymers via hydrolysable linkages provide controlled release of local anesthetics in vivo in an effective amount fornerve blockade with reduced toxicity relative to the unconjugated anesthetic agent. The rate of anesthetic release can be tuned by changing the hydrophilicity of the polymer. Exemplary formulations of Poly (glycerol sebacate) (PGS), optionally including Poly ethylene glycol (PEG) polymers conjugated to Tetrodotoxin (TTX) (PGS-PEG-TTX and PGS-TTX), and methods of use thereof are provided Nerve blockade from PGS-PEG-TTX and PGS-TTX was associated with minimal systemic and local toxicity to the muscle and the peripheral nerves. TDP-TTX conjugates homogeneously dispersed into PEG200 are also described. PEG200 not only worked as a medium, but also worked as a chemical permeation enhancer (CPE) to enhance the effectiveness of TTX.

The invention discloses a medical nerve block needle with a resistance feedback structure and a use method thereof, and particularly relates to the technical field of medical treatment, the medical nerve block needle comprises a needle body, a sealing tube is arranged in the needle body, the left end of the sealing tube is fixedly connected with the right end of a needle tip, a plurality of medicine openings are formed in the outer surface of the sealing tube, and the right end of the needle tip is fixedly connected with an elastic structure. The operation of compressing the elastic structure can be realized by increasing the puncture resistance of the needle tip, so that the sealing tube can be retracted into the needle body in the puncture process, the problem of blood backflow is prevented, meanwhile, the problem of failure caused by drug pollution is avoided, and when the elastic structure deforms due to resistance, the movement of a first piston can be controlled under the action of air pressure, then the resistance feedback effect can be achieved, timely adjustment of medical staff is facilitated, and the medical nerve block needle is simple in structure, easy to operate, low in manufacturing cost and good in use value.

The invention discloses a preparation method of a medicine porous sustained-release body. The method comprises the following steps of a) preparing a micron-sized porous sphere structure; b) combining the porous sphere structure with medicine molecules; and c) drying the combination of the porous sphere structure and the medicine molecules to obtain the medicine porous sustained-release body, wherein the porous sphere structure comprises a uniform macroporous sphere structure, a uniform mesoporous sphere structure and a non-uniform porous sphere structure. Correspondingly, the invention further provides the medicine porous sustained-release body prepared by using the preparation method. After entering the body, the medicine porous sustained-release body effectively realizes development under ultrasound by utilizing the scattering effect of the medicine porous sustained-release body on mechanical waves; and the action position of the medicine can be accurately positioned through ultrasonic development of the medicine porous sustained-release body, the action time of the medicine can be prolonged through the sustained-release effect of the medicine porous sustained-release body, and the accuracy of nerve block treatment and the bioavailability of the medicine are improved.

A system for infusing medication into a mammalian subject is provided. The system includes an injection system for controlling a flow of fluid from a fluid reservoir to a needle. A sensor is provided that detects a characteristic indicative of the fluid pressure in the needle. The injection system controls the flow of fluid to the needle in response to the characteristic detected by the sensor and the sensor continuously detects the characteristic as the needle is inserted into the subject. The system further includes a conductive element for providing electric nerve stimulation, wherein the system provides electric nerve stimulation in response to the sensor detecting a pressure exceeding an upper limit.

The invention relates to the field of medical supplies and particularly relates to a double-cavity injector capable of being used for ultrasonic guided nerve block. The injector comprises an injectorbody, an injector shunt end and an extension tube, wherein the injector shunt end consists of a first shunt tube, a second shunt tube, a base, an adjusting disc and an injector mastoid; the first shunt pipe and the second shunt pipe are communicated with the base, the base is connected with the mastoid in a sealed mode, the adjusting disc is provided with a first hole and a second hole respectively, and the adjusting disc is adjusted to rotate through an adjusting handle, so that the first shunt pipe and the second shunt pipe are communicated with the first hole and the second hole respectively, and on-off adjustment is achieved; the first shunt tube and the second shunt tube are respectively communicated with the medicine bag and the injector body. According to the injector, the hidden danger of injection pollution caused by replacing the injector back and forth in the processes of extracting and injecting normal saline and locally anesthetizing liquid medicine during nerve block under the guidance of ultrasonic waves is effectively solved.

The invention belongs to the technical field of medical instruments, and particularly relates to a nerve block medicine injection system capable of adjusting injection resistance. The nerve block medicine injection system comprises a workbench, an injection device, a main machine and a pedal device, the injection device and the main machine are installed on the workbench; the injection device comprises a hollow fixing box, a positioning assembly for fixing an injector and a driving assembly for pushing injection, and the positioning assembly comprises a pressure sensor for monitoring injection resistance; the main machine is used for receiving and displaying injection pressure information; and the pedal device is connected with the driving assembly and used for controlling the injection mode and speed. The defects in the prior art are overcome, the resistance in the injection process is displayed in real time, a single person is helped to operate, and the safety of nerve block medicine injection is improved.

The invention discloses an ultrasound developable high-adhesion drug sustained-release body for nerve block. The drug sustained-release body is a micron-order sphere structure of a medical material, the diameter of the sphere is 1-50 [mu] m, the sphere adhesion material realizes in-vivo adhesion through surface modification of adhesion molecules, and under the ultrasonic guidance, the development under the ultrasonic is realized by utilizing the scattering effect of the device on mechanical waves. The ultrasonic developable drug sustained-release body can accurately locate the action position of the drug, the action time of the drug can be prolonged through the adhesion and sustained-release effects of the drug sustained-release body, and the accuracy of nerve block treatment and the bioavailability of the drug are improved.

The invention discloses a nerve block system based on ultrasonic intelligent recognition, the nerve block system comprises an ultrasonic probe, an insertion needle head is arranged on the ultrasonic probe, and an anti-shake progressive mechanism is connected to the ultrasonic probe. According to the invention, the speed-limiting liquid discharging mechanism and the anti-shaking progressive mechanism are matched, and position stabilization and shake prevention during liquid medicine injection and flow speed reduction of the injection amount are realized; during specific implementation, the positions of the ultrasonic probe and the insertion needle head are fixed through the anti-shake progressive mechanism before the insertion needle head goes deep into the body of a patient, and after fixation is completed, the anti-shake progressive mechanism drives and controls the amount of the insertion needle head going deep into the body of the patient, meanwhile, the position of the insertion needle penetrating into the body of the patient is detected in real time through the ultrasonic probe and is imaged on an external imaging device to prevent the insertion needle from penetrating into the position mistakes, then liquid medicine is conveyed towards the inserted needle head through speed-limiting liquid discharging mechanism, and when the liquid medicine enters the insertion needle head, the conveying force of the liquid medicine is reduced so as to prevent the liquid medicine from rapidly impacting the deep part of the insertion needle head.

The invention discloses an ultrasound-guided puncture and nerve block auxiliary positioning device, which includes an adjustment mechanism, a lifting support rod and a positioning mechanism. , resetting groove, headrest, supporting desktop, display screen and computer mainframe, one side of the supporting bed board is dug with a horizontal chute, and the inside of the horizontal chute is connected with a horizontal screw rod for rotation, and the horizontal chute of the horizontal chute The horizontal slider is slidingly connected inside, and the horizontal screw passes through the middle of the horizontal slider, and the horizontal screw is screwed to the horizontal slider. By setting up an infrared auxiliary device and positioning mechanism, combined with computer integration , making it easier for the puncture needle and the scanning section to be on the same plane, increasing the imaging effect, inputting information in advance when a certain position needs to be punctured, and the computer can give a reminder at the position closest to the puncture, improving the success rate of puncture and reducing complications and anesthesia dosage.