The invention discloses a medical nerve block needle with a resistance feedback structure and a use method thereof, and particularly relates to the technical field of medical treatment, the medical nerve block needle comprises a needle body, a sealing tube is arranged in the needle body, the left end of the sealing tube is fixedly connected with the right end of a needle tip, a plurality of medicine openings are formed in the outer surface of the sealing tube, and the right end of the needle tip is fixedly connected with an elastic structure. The operation of compressing the elastic structure can be realized by increasing the puncture resistance of the needle tip, so that the sealing tube can be retracted into the needle body in the puncture process, the problem of blood backflow is prevented, meanwhile, the problem of failure caused by drug pollution is avoided, and when the elastic structure deforms due to resistance, the movement of a first piston can be controlled under the action of air pressure, then the resistance feedback effect can be achieved, timely adjustment of medical staff is facilitated, and the medical nerve block needle is simple in structure, easy to operate, low in manufacturing cost and good in use value.