The invention belongs to the technical field of traditional Chinese medicine, and discloses a plaster for treating bone joint and soft tissue disease pain and a preparation method thereof. The plasteris prepared from Chinese herbal medicines including impatiens balsamina, notopterygium root, dipsacus root, ligusticum wallichii, flos daturae, little multibanded krait, croton, radix angelicae, radix morindae officinalis, pillbug, rhizoma drynariae, radix stephaniae tetrandrae and the like. The plaster is rigorous and proper in compatibility and unique in preparation method, and has the effectsof warming channels and dispelling cold, dispelling wind and eliminating dampness, promoting blood circulation to remove meridian obstruction, relieving swelling and pain, promoting reunion of fractured bones and the like. The plaster is remarkable in curative effect, takes effect quickly, shortens the disease course, and is high in cure rate, convenient to use, free of toxic and side effects andlow in cost. The plaster has unique remarkable curative effects on cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, sciatica, lumbar spinal stenosis, rheumatic arthritis, lumbar muscle strain, osteoproliferation, waist and limb joint pain, closed fracture, sprain, contusion, soft tissue injury and other bone joint and soft tissue diseases.