23 results about "Arthropathy" patented technology

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

An object is to provide a joint function-improving composition which is useful for prevention or treatment of various arthropathies such as osteoarthritis including knee osteoarthritis as a typical example and rheumatoid arthritis because the composition has an action of promoting growth of chondrocytes and an action of suppressing the production of an inflammation factor, a cartilage matrix degradation factor, a pain factor or a neuronal outgrowth factor by synoviocytes and to provide a joint function-improving product containing the composition such as a food or a drink, feed and a medicine. A joint function-improving composition containing bacterial cells and / or a culture of a bacterium belonging to genera Lactobacillus, Lactococcus, Streptococcus or Bifidobacterium and a joint function-improving agent, a joint function-improving food or drink, a joint function-improving nutritional composition, joint function-improving feed or a joint function-improving pharmaceutical agent which is characterized by containing the joint function-improving composition.

Methods of determining the risk of developing adjudicated arthropathy (AA) and / or progression to total joint replacement (TJR) and determining the treatment response to an NGF antagonist or NSAID treatment in a subject by determination of an OA proteomic risk score for the subject are presented herein.

Methods of determining the risk of developing adjudicated arthropathy (AA) and / or progression to total joint replacement (TJR) and determining the treatment response to an NGF antagonist or NSAID treatment in a subject by determination of an OA proteomic risk score for the subject are presented herein.

The invention relates to the field of diagnostic kits, in particular to application of an IGHV family molecule as a diagnostic marker in preparation of a diagnostic kit for psoriasis (PSO) and arthropathy type psoriasis (PsA), and the IGHV family molecule is selected from IGHV3-72, IGHV5-51, IGHG3, IGHV1-69, IGHV3-73 and / or IGHV3-9. Wherein the prediction efficiency of the IGHG3 is the highest, and the area under the curve (AUC) is 0.826 (95% CI: 0.693-0.959). IGHV family molecules are specifically expressed in psoriasis, the diagnosis specificity is high, and the cross reaction with other autoimmune diseases can be reduced; the invasive operation of skin biopsy can be avoided through nail sample detection; the kit is suitable for early screening of PSO, early diagnosis and prediction of PsA and dynamic monitoring of curative effect, and is widely applied.

The invention discloses an orthopedic intelligent rehabilitation training device with a pressure sensing function, which comprises two bottom plates connected together in a 360-degree rotation manner, a support pad for supporting the shank of a patient is regularly arranged at the upper end of the first bottom plate, and adjustable lifting pads are regularly arranged at the front end or the front and rear ends of the support pad; the adjustable lifting pad is used for adjusting the height of feet or legs of the patient; training pedals elastically connected with the second bottom plate are regularly arranged at the upper end of the second bottom plate, and elastic pieces for providing elastic force are regularly arranged between the training pedals; training shoes for a patient to wear are regularly arranged on the surface of the training pedal. The intelligent rehabilitation training device for the orthopedics department can help patients after the orthopedics department and the surgery department to carry out effective muscle contraction training of ankle joint motion range, thigh quadriceps femoris muscle, triceps calf muscle and the like, and rehabilitation training of patients suffering from knee joint diseases and lower limb fractures in the early-stage postoperative bed-lying period or patients who cannot sit for a long time and the like; meanwhile, the blood flow rate can be improved, and blood circulation is promoted.

The present invention relates a composition for use in increasing the longevity and / or enhancing healthy aging of a subject, particularly a human subject, and methods thereof. The composition comprises at least one of: isoscabertopin; 1,7-Bis (hydroxyphenyl)-4-hepten-3-one; eupafolin; isokuranetin, (E) - aldosecologanin, or any combination thereof, and increases expression of or activates a transcription factor selected from the group consisting of: nuclear factor (erythroid-derived 2)-like 2 (NRF2), Forkhead box O3 (FOXO3) and Grainy head 1 (GRHL1). Non-therapeutic or therapeutic uses and methods are disclosed herein. The extending longevity includes stimulating innate immunity, resistance against oxidative stress, inhibition of tumor cell growth, treating or preventing age-related diseases and disorders, which include: inflammation and inflammatory diseases, non-communicable diseases including: cardiovascular diseases, arthropathies, cancer, neurodegenerative diseases, diabetes, frailty, decline of physical fitness, decline of physical endurance or combinations thereof.

1. Name of the product in this design: Handheld Ultrasonic Therapy Device. 2. Purpose of this design: To relieve pain and inflammation caused by soft tissue injuries such as muscles, tendons, and ligaments, and to assist in the treatment of joint conditions such as arthritis to reduce stiffness and pain. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A method of treating a subject having an articular disorder by administration of a long-acting liposomal composition. A preferred liposomal composition includes a phosphatidylcholine as the sole active ingredient, wherein the phosphatidylcholine is selected from the group consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phosphocholine, N-palmitoyl-D-erythro-sphingosylphosphorylcholine, and a combination thereof. A preferred administration is by a single intra-articular injection once or every 4 to 12 months to afford pain relief and / or reduction of irritation in the joint of the subject.

The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

The present invention relates to a complex for promoting cartilage differentiation comprising stem cells or a culture thereof and a cartilage cell-free crush, a method for fabricating cartilage by using the complex, cartilage fabricated via the method, a pharmaceutical composition comprising the complex for preventing or treating arthropathy, a method for preventing or treating arthropathy using the composition, a composition for inducing cartilage cell differentiation comprising the prepared cartilage cells, and a method for fabricating cartilage using the prepared cartilage cells. The complex for promoting cartilage differentiation comprising the stem cells or the culture thereof and the cartilage cell-free crush provided in the present invention is not only differentiated into cartilage cells without side effects even in vivo, but also promotes differentiation of inherent stem cells in vivo into cartilage cells via a paracrine effect exhibited in the differentiated cartilage cells to effectively regenerate the damaged cartilage, and thus the complex may be widely used for treatment of arthropathy involving the cartilage damage.

The utility model relates to a flushing device for a joint focus part in a minimally invasive surgery, which is characterized by comprising a sheath tube, a waterway assembly, an endoscope sheath main body and a locking assembly, one end of the sheath tube is arranged in an inner hole of the endoscope sheath main body and is detachably connected with the endoscope sheath main body, and the waterway assembly comprises a water valve seat, an upper water valve and a lower water valve. The water valve seat is sleeved on the periphery of the front end of the endoscope sheath body, the upper water valve and the lower water valve are mounted on two sides of the water valve seat and used for water injection and water discharge respectively, the upper water valve and the lower water valve are communicated with an inner hole of the endoscope sheath body, and a space between the inside of the sheath tube and the outer wall of the arthroscope inserted into the sheath tube forms a flushing channel. The locking assembly is arranged on the periphery of the rear end of the arthroscope sheath body, and the arthroscope handle and the arthroscope sheath body are sealed and locked through the locking assembly. According to the utility model, blood and bone debris can be synchronously cleaned during an operation, so that an operation site is always kept clean, the visual field is clear, and the operation progress and the operation quality are effectively improved.

The application discloses a kind of cross-modal spinal structure damage quantification method and system, belong to medical image processing and depth learning auxiliary evaluation technical field.The method obtains the median sagittal CT image and standard lumbar lateral X-ray film of the same examinee, after standardization pretreatment, respectively input the double-flow Swin Transformer feature extraction network with same structure but independent weight;Again through bidirectional cross-modal attention module, with one side modal feature through bottleneck type gate network generates channel level attention weight, act on opposite side modal feature and introduce residual connection;After the features of bidirectional calibration are spliced, input multi-head MLP classifier, output the structural damage severity classification (Grade 0 / 1 / 2) of four corner points (front upper, front lower, back upper, back lower) of vertebral unit.The self-excitation logic of general attention is transformed into cross-modal mutual excitation logic in the application, explicitly uses CT tomographic structure prior to suppress X-ray projection artifact, and uses X-ray overall topological constraint CT local feature, realizes AUC=0.9128, QWK=0.7879 on internal independent test set, and the grade consistency is significantly better than simple feature splicing and primary clinician, provides objective and efficient quantification tool for the standardization follow-up of ankylosing spondylitis and other spinal joint disease structural damage.

The present invention relates to a pharmaceutical composition in the form of a sterile and injectable dosage form comprising a controlled release dosage form comprising colchicine for use in the treatment of arthropathy, such as osteoarthritis, aggressive hand osteoarthritis and any other type of chondropathy, by intraarticular injection of said pharmaceutical composition into the joint, such as osteoarthritis, aggressive hand osteoarthritis, and any other type of chondropathy. The present invention relates to colchicine, in particular colchicine, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages, in which 80% by weight of colchicine is released for more than one month, and in which colchicine is present in a concentration of 1 to 27.5 mg per mL of sterile and injectable dosage, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages. The invention also relates to a sterile and injectable pharmaceutical composition comprising a controlled release dosage form containing colchicine, which has a suitable in vitro dissolution characteristic. The invention also relates to a formulation in powder form and to a pharmaceutical composition in sterile and injectable dosage form form suitable for intra-articular injection comprising colchicine, in particulate form comprising a polymer matrix, and to a related kit or article of manufacture.

The present disclosure relates to a knee joint lesion detection method and device, an electronic device and a storage medium, and relates to the technical field of knee joint lesion detection. The method comprises: performing similarity information calculation on a T1 first image and a T2 second image in an acquired knee image, and obtaining a corresponding third image based on the similarity information; synthesizing the T1 first image, the T2 second image and the third image to obtain a to-be-processed image; and performing knee joint lesion detection on the to-be-processed image based on a preset target detection model. The present disclosure can realize knee joint lesion detection.

The present invention relates to a pharmaceutical composition suitable for intra-articular injection, comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine. Furthermore, the present invention relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine, wherein the controlled-release dosage form containing colchicine is in the form of fine particles. Furthermore, the present invention relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine, wherein the controlled-release dosage form containing colchicine is in the form of fine particles, a kit, and the use of the pharmaceutical composition or kit in the treatment of crystal-associated acute inflammatory arthritis and amorphous acute inflammatory arthritis, particularly crystal-associated arthropathy or erythema or acute type tendinitis and capsulitis, by intra-articular injection of the pharmaceutical composition into the joint, providing immediate and overall treatment-long analgesia.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis and an extraction process thereof. The traditional Chinese medicine composition is prepared from 10-30 g of thorny elaeagnus root, 10-30 g of bark of himalayan coralbean, 10-30 g of kadsura longepedunculata root, 5-15 g of waxberry root, 5-15 g of ardisia crenata, 5-15 g of rose mallow root, 5-15 g of glabrous sarcandra herb and 3-9 g of wikstroemia canescens root. The extraction process comprises the following steps: crushing the traditional Chinese medicine components, sieving with a 12-mesh sieve, uniformly mixing, adopting 60-80% ethanol as an extraction solvent, performing ultrasonic extraction under the conditions that the ultrasonic power is 500-700W, the frequency is 20-30KHz, the extraction temperature is 40-60 DEG C, the extraction time is 30-90min and the material-liquid ratio is (8-12): 1 (mL / g), performing suction filtration, and complementing the original volume to obtain an extracting solution. By optimizing the extraction process, the extraction efficiency and the quality stability are ensured; the extracting solution of the traditional Chinese medicine composition can remarkably reduce the thickness of toes of mice, adjust oxidative stress indexes, improve joint pathological injuries and regulate and control JAK2 / STAT3 pathway related protein expression, so that the effect of resisting rheumatoid arthritis is achieved.

The utility model relates to the technical field related to arthropathy, and discloses an assisted joint recovery device for the department of rheumatism and immunology. The fixing assembly comprises a first fixing piece, a second fixing piece and a third fixing piece, the second fixing piece is arranged at the other end of the first connecting rod. The connecting piece is arranged on the connecting rod I; a movable assembly is further arranged on the fixed assembly, and the movable assembly comprises a sliding rail arranged on a second fixed part; when in use, the knee joint assisting device is fixed on a leg through the fixing assembly, the knee joint can be bent during walking, then the second connecting rod is driven to move downwards to compress the spring, and then the spring automatically rebounds after receiving pressure, so that the second connecting rod is driven again to move upwards, and the purpose of assisting a joint patient in walking is achieved. The problem that a traditional joint assisting recovery device does not have the function of assisting a patient in walking is solved, during daily rehabilitation training, bending training of knee joints can be completely exercised by means of the device, and the functionality and practicability of the device are greatly improved.

The application belongs to the technical field of medical devices, and particularly relates to a nested loosing needle device for injectable medicine, which comprises an injection structure, an injection needle body and a loosing needle body. The injection needle body is arranged on the port of the injection structure and used for puncturing the skin and injecting medicine. The loosing needle body has an inner through hole and is used for being sleeved on the outer periphery of the injection needle body to realize the switching between the two states of the exposed injection needle body and the retracted loosing needle body. One end of the loosing needle body is smoothly connected with the injection needle body and used for puncturing the skin. The composite sleeve design realizes the loosing and medicine injection functions of the needle device, significantly reduces the operation times, reduces the pain of patients, and improves the treatment efficiency and safety for complex diseases such as connective tissue diseases, bone joint diseases and soft tissue diseases. The design fills the blank of the multifunctional needle device in the prior art and has significant clinical application value.

The utility model discloses a lumbar and dorsal muscle exerciser for spinal degenerative joint diseases, and relates to the technical field of medical fitness equipment. The device structurally comprises a base plate, a spine exerciser, two waist and back exercisers and two electric lead screw double-sliding-block mechanisms. The spine exerciser is fixed in the middle of the base plate; the two waist and back exercisers are installed on the two sides of the spine exerciser in a hinged mode through hinged supports. The stability and the use convenience are considered through the design of the base plate, the spine exerciser is used for carrying out rolling massage on the spine in a targeted mode, the waist and back exerciser is installed in a hinged mode to meet the waist and back muscle exercise requirements of different patients, and the possibility of accurately adjusting the turning angle is provided through an electric lead screw double-sliding-block mechanism; the rolling effect and the exercise experience are enhanced through the protruding parts on the roller with the shaft; the design details jointly improve the applicability, the safety and the effectiveness of the exerciser, so that the exerciser becomes an ideal choice for daily rehabilitation exercise of the patient with the spinal degenerative joint disease.

The invention discloses a preparation method and application of oral microspheres containing chlorella and ginseng polysaccharide, and belongs to the technical field of biological medicine. The oral microspheres are prepared in a water-in-oil manner by utilizing a microfluidic technology, the microspheres are loaded with chlorella and ginseng polysaccharide, and a thermal response gel network is formed by taking methylacryloylated gelatin as a carrier. The prepared microspheres are stable in the stomach environment, can be gelated and gradually degraded under the induction of temperature in the intestinal tract after being orally taken, and slowly release active ingredients, so that the intestinal targeted delivery efficiency of the microspheres is effectively improved. The oral microspheres have multiple functions of regulating intestinal flora, repairing intestinal barriers, reducing intestinal permeability and regulating system immunity, and can remarkably improve intestinal and joint pathological manifestations related to rheumatoid arthritis. Furthermore, the joint cavity injection glucocorticoid is combined, so that the synergistic treatment of intestinal tracts and joints can be realized, and the anti-inflammatory and tissue protection effects are enhanced. The system is good in safety and stable in preparation process, and has wide application potential in rheumatoid arthritis and other chronic inflammatory diseases.

A method of treating a subject having an articular disorder by administration of a long-acting liposomal composition. A preferred liposomal composition includes a phosphatidylcholine as the sole active ingredient, wherein the phosphatidylcholine is selected from the group consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phosphocholine, N-palmitoyl-D-erythro-sphingosylphosphorylcholine, and a combination thereof. The method provides a pain relief to the subject for at least 6 months which is manifested by a reduction from baseline or untreated control of at least 15 as determined by average of global pain achieved at about 26 weeks following administration.

The utility model discloses a temporomandibular joint disease relaxation decompression device which comprises a base plate, the base plate is in an arch shape matched with a dental arch, and a telescopic dental pad is arranged on the base plate. According to the relaxation decompression device for the temporomandibular arthropathy, the thickness can be flexibly adjusted, and flexibility and comfort are both considered.