41 results about "Arthropathy" patented technology

The present invention addresses the problem of providing: synovium-derived mesenchymal stem cells that stably exhibit an excellent therapeutic effect on joint diseases; an arthropathy therapeutic agent that contains the synovium-derived mesenchymal stem cells; a method for producing the synovium-derived mesenchymal stem cells; and a method for selecting synovium-derived mesenchymal stem cells for use as an arthropathy therapeutic agent. The present invention provides synovium-derived mesenchymal stem cells that express at least one of a hepatocyte growth factor, a transforming growth factor β-inducing protein, and tumor necrosis factor superfamily 15.

The traditional Chinese medicine fumigation cylinder is provided with a medicine boiling box, a steam outlet pipe fixedly penetrates through the center of the top of the medicine boiling box, and a slow flow box is fixed to the top of the steam outlet pipe; comprising a drainage plate fixed to the inner top face of the flow slowing box, and a backflow pipe is fixed to the edge of the bottom of the drainage plate; the fixing pipe penetrates through the top of the slow flow box, a fumigation barrel is fixedly installed at the top of the fixing pipe, and a containing groove is formed in the side face of the fumigation barrel; an air conveying channel is formed in the inner wall of the fumigation barrel, and the other end of the connecting hose is connected with a movable ring. According to the traditional Chinese medicine fumigation cylinder for treating the arthropathy in the traditional Chinese medicine mode, steam generated in the traditional Chinese medicine steaming process can intercept a large amount of liquid contained in gas, then contact between the liquid and the human body is reduced, a small number of air nozzles are arranged, medicine can be sprayed in a concentrated mode, comprehensive fumigation on joints is achieved, and therefore the medicine effect can be improved.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

The invention discloses ointment for relieving swelling and ostealgia and promoting tissue regeneration and a preparation method thereof, and relates to the field of traditional Chinese medicine, and the ointment is prepared from the following raw materials: catechu, cape jasmine, trogopterus dung, kadsura root-bark, madder, dragon's blood, rheum officinale, frankincense and myrrh. According to the swelling-eliminating ostealgia granulation-promoting ointment and the preparation method thereof, by scientifically compounding a plurality of traditional Chinese medicinal materials capable of promoting blood circulation to remove blood stasis and promoting granulation to relieve pain and combining with an accurate grinding process and an optimized proportion of a honey matrix, the medicine permeability and bioavailability of the ointment are remarkably improved; the traditional Chinese medicine composition has multiple effects of relieving swelling and pain, promoting blood circulation to remove blood stasis, relaxing tendons and activating collaterals, and promoting tissue regeneration and strengthening muscles and bones, and particularly has a more remarkable curative effect on edema pain caused by rheumatism, rheumatoid, gout and various osteoarthropathy and diseases such as early bone fracture, bone fracture and fracture.

The present invention relates to a pharmaceutical composition suitable for intraarticular injection comprising an anesthetic and an immediate release or controlled release dosage form comprising colchicine. It also relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate release or controlled release dosage form comprising colchicine wherein the controlled release dosage form comprising colchicine is in particulate form. It also relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate release or controlled release dosage form comprising colchicine wherein the controlled release dosage form comprising colchicine is in particulate form, relates to a pharmaceutical composition, to a kit and to the use of said pharmaceutical composition or kit in the treatment of crystal-related and non-crystal-related acute inflammatory arthritis, in particular crystal-related arthropathy or sudden or acute forms of tendinitis and bursitis, by intra-articular injection of said pharmaceutical composition into the joint, and to the use of said pharmaceutical composition or kit in the treatment of crystal-related and non-crystal-related acute inflammatory arthritis, in particular crystal-related arthropathy or sudden or acute forms of tendinitis and bursitis, and to provide pain relief immediately and throughout the treatment.

An object is to provide a joint function-improving composition which is useful for prevention or treatment of various arthropathies such as osteoarthritis including knee osteoarthritis as a typical example and rheumatoid arthritis because the composition has an action of promoting growth of chondrocytes and an action of suppressing the production of an inflammation factor, a cartilage matrix degradation factor, a pain factor or a neuronal outgrowth factor by synoviocytes and to provide a joint function-improving product containing the composition such as a food or a drink, feed and a medicine. A joint function-improving composition containing bacterial cells and / or a culture of a bacterium belonging to genera Lactobacillus, Lactococcus, Streptococcus or Bifidobacterium and a joint function-improving agent, a joint function-improving food or drink, a joint function-improving nutritional composition, joint function-improving feed or a joint function-improving pharmaceutical agent which is characterized by containing the joint function-improving composition.

The invention discloses a self-adaptive fluid insole and a shoe comprising the same. The self-adaptive fluid insole comprises an adjusting fluid pad, a flexible pressure sensor, an empty groove, a fixing bolt, a transmission line and a line groove. The fluid adjusting pad is located at the bottom end of the shoe pad and internally provided with fluid; the flexible pressure sensor comprises a sensing part located above the adjusting fluid pad and a driving circuit located behind the heel or on the sole, the sensing part is in attached contact with the foot sole of the patient, and compensation supporting force is further provided according to detected pressure distribution of the foot sole of the patient after reactive force supporting is provided through fluid. According to foot shapes and pressure characteristics of different patient groups, through self-adaptive adjustment of fluid and multi-section pressure detection of a flexible pressure sensor, the detection precision and information richness are improved, pressure dispersion and dynamic adjustment of supporting force are achieved, the plantar condition of a patient can be improved, even the arch is corrected to a certain degree, and the patient's health is improved. Arthropathy is prevented, and healthy walking time is prolonged.

Compositions and peptides for enhancing formation of cartilage in a site of a cartilage injury or defect, or joint condition, and methods of the use of the compositions and peptides in such treatments. Examples of the sites may include a knee, ankle, wrist, shoulder, elbow, patella, hip, vertebrae, femoral head, temporomandibular joint, glenoid of the scapula, jaw, and growth plate.

Methods of determining the risk of developing adjudicated arthropathy (AA) and / or progression to total joint replacement (TJR) and determining the treatment response to an NGF antagonist or NSAID treatment in a subject by determination of an OA proteomic risk score for the subject are presented herein.

The present invention relates to a fully automatic spatial registration system based on multimodal information fusion, comprising: a preoperative planning module for fusing preoperative knee joint MRI and CT images to reconstruct a "bone + cartilage" combined navigation model; an intraoperative point cloud extraction module for scanning and automatically extracting intraoperative knee joint lesion cartilage surface point cloud data; and a spatial registration module for aligning the cartilage surface point cloud reconstructed in the preoperative CT image space with the cartilage surface point cloud data scanned intraoperatively, thereby achieving navigation registration between the intraoperative patient space and the preoperative image space. The present invention's point cloud-based registration method can achieve similar accuracy registration without selecting anatomical points, greatly reducing the degree of dependence on the doctor. This technology greatly assists doctors, allowing them to focus more on the surgery itself.

Methods of determining the risk of developing adjudicated arthropathy (AA) and / or progression to total joint replacement (TJR) and determining the treatment response to an NGF antagonist or NSAID treatment in a subject by determination of an OA proteomic risk score for the subject are presented herein.

The invention relates to the field of diagnostic kits, in particular to application of an IGHV family molecule as a diagnostic marker in preparation of a diagnostic kit for psoriasis (PSO) and arthropathy type psoriasis (PsA), and the IGHV family molecule is selected from IGHV3-72, IGHV5-51, IGHG3, IGHV1-69, IGHV3-73 and / or IGHV3-9. Wherein the prediction efficiency of the IGHG3 is the highest, and the area under the curve (AUC) is 0.826 (95% CI: 0.693-0.959). IGHV family molecules are specifically expressed in psoriasis, the diagnosis specificity is high, and the cross reaction with other autoimmune diseases can be reduced; the invasive operation of skin biopsy can be avoided through nail sample detection; the kit is suitable for early screening of PSO, early diagnosis and prediction of PsA and dynamic monitoring of curative effect, and is widely applied.

The utility model relates to the technical field of rheumatism joint physiotherapy, and discloses a rheumatism immune arthropathy rehabilitation physiotherapy device which comprises a base, a resistance adjusting assembly and a pedal assembly, the resistance adjusting assembly is arranged at one end of the base, the pedal assembly is connected to the base in a sliding mode, the pedal assembly is connected with the resistance adjusting assembly, and the resistance adjusting assembly is arranged on the base. The resistance adjusting assembly comprises a spiral rod, a one-way ratchet wheel, a driven ratchet wheel sleeve, a resistance friction wheel, a rotating shaft and a friction ring, the one-way ratchet wheel is fixedly connected to one end of the spiral rod, and the driven ratchet wheel sleeve and the resistance friction wheel are fixedly connected through a rotating shaft. According to the rheumatism immune joint disease rehabilitation training device, by arranging the resistance adjusting assembly, the elastic force provided by the spring rod to the friction ring can be conveniently changed, then the pressure between the friction ring and the resistance friction wheel is changed, training resistance adjustment is achieved, the device can adapt to different patient degrees, and the training rehabilitation effect of the rheumatism immune joint disease is effectively improved.

The invention discloses an orthopedic intelligent rehabilitation training device with a pressure sensing function, which comprises two bottom plates connected together in a 360-degree rotation manner, a support pad for supporting the shank of a patient is regularly arranged at the upper end of the first bottom plate, and adjustable lifting pads are regularly arranged at the front end or the front and rear ends of the support pad; the adjustable lifting pad is used for adjusting the height of feet or legs of the patient; training pedals elastically connected with the second bottom plate are regularly arranged at the upper end of the second bottom plate, and elastic pieces for providing elastic force are regularly arranged between the training pedals; training shoes for a patient to wear are regularly arranged on the surface of the training pedal. The intelligent rehabilitation training device for the orthopedics department can help patients after the orthopedics department and the surgery department to carry out effective muscle contraction training of ankle joint motion range, thigh quadriceps femoris muscle, triceps calf muscle and the like, and rehabilitation training of patients suffering from knee joint diseases and lower limb fractures in the early-stage postoperative bed-lying period or patients who cannot sit for a long time and the like; meanwhile, the blood flow rate can be improved, and blood circulation is promoted.

The present invention relates a composition for use in increasing the longevity and / or enhancing healthy aging of a subject, particularly a human subject, and methods thereof. The composition comprises at least one of: isoscabertopin; 1,7-Bis (hydroxyphenyl)-4-hepten-3-one; eupafolin; isokuranetin, (E) - aldosecologanin, or any combination thereof, and increases expression of or activates a transcription factor selected from the group consisting of: nuclear factor (erythroid-derived 2)-like 2 (NRF2), Forkhead box O3 (FOXO3) and Grainy head 1 (GRHL1). Non-therapeutic or therapeutic uses and methods are disclosed herein. The extending longevity includes stimulating innate immunity, resistance against oxidative stress, inhibition of tumor cell growth, treating or preventing age-related diseases and disorders, which include: inflammation and inflammatory diseases, non-communicable diseases including: cardiovascular diseases, arthropathies, cancer, neurodegenerative diseases, diabetes, frailty, decline of physical fitness, decline of physical endurance or combinations thereof.

The invention discloses herbal essence essential oil extracted from ancient prescription traditional Chinese medicines. The composition is composed of a basic formula, carrier oil, a synergist and a flavoring agent. A basic formula contains multiple traditional Chinese medicines such as clove and radix aucklandiae, for example, clove can resist bacteria and inflammation, and pearl powder can whiten and moisten skin. Camellia oil is selected as carrier oil and has moistening and absorption promoting effects. The synergist contains sulfur, a potassium permanganate solution and the like and has synergistic sterilization and anti-inflammation effects. The flavoring agent is edible-grade essence, so that the smell is improved, and the mood is relieved. The preparation method comprises the following steps: pretreating the basic formula components, soaking the carrier oil, preparing the synergist, blending twice, mixing with the synergist and the like. The essential oil is comprehensive in efficacy, can be externally applied to treat skin diseases, can be used for relieving arthropathy through essential oil massage and improving various body discomforts through abdomen massage, is natural and safe, is scientific in formula, and has great application value in the fields of medical treatment, health care and skincare.

1. Name of the product in this design: Handheld Ultrasonic Therapy Device. 2. Purpose of this design: To relieve pain and inflammation caused by soft tissue injuries such as muscles, tendons, and ligaments, and to assist in the treatment of joint conditions such as arthritis to reduce stiffness and pain. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention relates to the technical field of traditional Chinese medicine composition preparation, in particular to a preparation method of a traditional Chinese medicine composition for arthropathy heat syndrome, which comprises the following steps: putting unit volume of spare medicinal materials into an unheated decocting pot to test the floating performance of the spare medicinal materials; collecting floating positions of the standby medicinal materials in the medicine decocting pot in a single monitoring period; determining the cutting size of the standby medicinal material based on the floating performance of the standby medicinal material; according to the cutting size, the putting priority of the standby medicinal materials put into the medicine decocting pot is determined; the temperature increasing speed of the medicine decocting pot is determined according to the adhesion area of the standby medicinal materials in the medicine decocting pot; the medicine decocting pot is heated according to the temperature increasing speed to output medicine liquid to be filtered; the traditional Chinese medicine composition is prepared from 10 g of radix paeoniae rubra, 15 g of rhizoma polygoni cuspidati, 20 g of radix euphorbiae, 20 g of semen coicis, 15 g of ramulus mori, 10 g of radix salviae miltiorrhizae, 10 g of herba epimedii, 10 g of radix achyranthis bidentatae The preparation quality of the traditional Chinese medicine composition is improved.

A method of treating a subject having an articular disorder by administration of a long-acting liposomal composition. A preferred liposomal composition includes a phosphatidylcholine as the sole active ingredient, wherein the phosphatidylcholine is selected from the group consisting of 1,2-dimyristoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, 1,2-dipentadecanoyl-sn-glycero-3-phosphocholine, 1,2-distearoyl-sn-glycero-3-phosphocholine, N-palmitoyl-D-erythro-sphingosylphosphorylcholine, and a combination thereof. A preferred administration is by a single intra-articular injection once or every 4 to 12 months to afford pain relief and / or reduction of irritation in the joint of the subject.

The present invention provides compositions and methods for treating joint disorders that are characterized by an inflammatory component. In some aspects, the compositions and methods are to prevent the progression of osteoarthritis and other arthritides and to treat osteoarthritis and other arthritides in a mammalian joint.

The present invention relates to a complex for promoting cartilage differentiation comprising stem cells or a culture thereof and a cartilage cell-free crush, a method for fabricating cartilage by using the complex, cartilage fabricated via the method, a pharmaceutical composition comprising the complex for preventing or treating arthropathy, a method for preventing or treating arthropathy using the composition, a composition for inducing cartilage cell differentiation comprising the prepared cartilage cells, and a method for fabricating cartilage using the prepared cartilage cells. The complex for promoting cartilage differentiation comprising the stem cells or the culture thereof and the cartilage cell-free crush provided in the present invention is not only differentiated into cartilage cells without side effects even in vivo, but also promotes differentiation of inherent stem cells in vivo into cartilage cells via a paracrine effect exhibited in the differentiated cartilage cells to effectively regenerate the damaged cartilage, and thus the complex may be widely used for treatment of arthropathy involving the cartilage damage.

1. The name of the product under this design: Therapeutic Device (Slim Waist). 2. Purpose of this design product: This design product is used as a therapeutic device for cervical spondylosis, lumbar spondylosis, osteoarthritis, arthritis, and periarthritis of the shoulder. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The utility model relates to a flushing device for a joint focus part in a minimally invasive surgery, which is characterized by comprising a sheath tube, a waterway assembly, an endoscope sheath main body and a locking assembly, one end of the sheath tube is arranged in an inner hole of the endoscope sheath main body and is detachably connected with the endoscope sheath main body, and the waterway assembly comprises a water valve seat, an upper water valve and a lower water valve. The water valve seat is sleeved on the periphery of the front end of the endoscope sheath body, the upper water valve and the lower water valve are mounted on two sides of the water valve seat and used for water injection and water discharge respectively, the upper water valve and the lower water valve are communicated with an inner hole of the endoscope sheath body, and a space between the inside of the sheath tube and the outer wall of the arthroscope inserted into the sheath tube forms a flushing channel. The locking assembly is arranged on the periphery of the rear end of the arthroscope sheath body, and the arthroscope handle and the arthroscope sheath body are sealed and locked through the locking assembly. According to the utility model, blood and bone debris can be synchronously cleaned during an operation, so that an operation site is always kept clean, the visual field is clear, and the operation progress and the operation quality are effectively improved.

The application discloses a kind of cross-modal spinal structure damage quantification method and system, belong to medical image processing and depth learning auxiliary evaluation technical field.The method obtains the median sagittal CT image and standard lumbar lateral X-ray film of the same examinee, after standardization pretreatment, respectively input the double-flow Swin Transformer feature extraction network with same structure but independent weight;Again through bidirectional cross-modal attention module, with one side modal feature through bottleneck type gate network generates channel level attention weight, act on opposite side modal feature and introduce residual connection;After the features of bidirectional calibration are spliced, input multi-head MLP classifier, output the structural damage severity classification (Grade 0 / 1 / 2) of four corner points (front upper, front lower, back upper, back lower) of vertebral unit.The self-excitation logic of general attention is transformed into cross-modal mutual excitation logic in the application, explicitly uses CT tomographic structure prior to suppress X-ray projection artifact, and uses X-ray overall topological constraint CT local feature, realizes AUC=0.9128, QWK=0.7879 on internal independent test set, and the grade consistency is significantly better than simple feature splicing and primary clinician, provides objective and efficient quantification tool for the standardization follow-up of ankylosing spondylitis and other spinal joint disease structural damage.

The present invention relates to a pharmaceutical composition in the form of a sterile and injectable dosage form comprising a controlled release dosage form comprising colchicine for use in the treatment of arthropathy, such as osteoarthritis, aggressive hand osteoarthritis and any other type of chondropathy, by intraarticular injection of said pharmaceutical composition into the joint, such as osteoarthritis, aggressive hand osteoarthritis, and any other type of chondropathy. The present invention relates to colchicine, in particular colchicine, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages, in which 80% by weight of colchicine is released for more than one month, and in which colchicine is present in a concentration of 1 to 27.5 mg per mL of sterile and injectable dosage, and / or for the treatment of pain-related arthropathy, and / or for the protection of joints, bones and / or cartilages. The invention also relates to a sterile and injectable pharmaceutical composition comprising a controlled release dosage form containing colchicine, which has a suitable in vitro dissolution characteristic. The invention also relates to a formulation in powder form and to a pharmaceutical composition in sterile and injectable dosage form form suitable for intra-articular injection comprising colchicine, in particulate form comprising a polymer matrix, and to a related kit or article of manufacture.

The present disclosure relates to a knee joint lesion detection method and device, an electronic device and a storage medium, and relates to the technical field of knee joint lesion detection. The method comprises: performing similarity information calculation on a T1 first image and a T2 second image in an acquired knee image, and obtaining a corresponding third image based on the similarity information; synthesizing the T1 first image, the T2 second image and the third image to obtain a to-be-processed image; and performing knee joint lesion detection on the to-be-processed image based on a preset target detection model. The present disclosure can realize knee joint lesion detection.

The present invention relates to a pharmaceutical composition suitable for intra-articular injection, comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine. Furthermore, the present invention relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine, wherein the controlled-release dosage form containing colchicine is in the form of fine particles. Furthermore, the present invention relates to a pharmaceutical composition in powder form comprising an anesthetic and an immediate-release or controlled-release dosage form containing colchicine, wherein the controlled-release dosage form containing colchicine is in the form of fine particles, a kit, and the use of the pharmaceutical composition or kit in the treatment of crystal-associated acute inflammatory arthritis and amorphous acute inflammatory arthritis, particularly crystal-associated arthropathy or erythema or acute type tendinitis and capsulitis, by intra-articular injection of the pharmaceutical composition into the joint, providing immediate and overall treatment-long analgesia.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis and an extraction process thereof. The traditional Chinese medicine composition is prepared from 10-30 g of thorny elaeagnus root, 10-30 g of bark of himalayan coralbean, 10-30 g of kadsura longepedunculata root, 5-15 g of waxberry root, 5-15 g of ardisia crenata, 5-15 g of rose mallow root, 5-15 g of glabrous sarcandra herb and 3-9 g of wikstroemia canescens root. The extraction process comprises the following steps: crushing the traditional Chinese medicine components, sieving with a 12-mesh sieve, uniformly mixing, adopting 60-80% ethanol as an extraction solvent, performing ultrasonic extraction under the conditions that the ultrasonic power is 500-700W, the frequency is 20-30KHz, the extraction temperature is 40-60 DEG C, the extraction time is 30-90min and the material-liquid ratio is (8-12): 1 (mL / g), performing suction filtration, and complementing the original volume to obtain an extracting solution. By optimizing the extraction process, the extraction efficiency and the quality stability are ensured; the extracting solution of the traditional Chinese medicine composition can remarkably reduce the thickness of toes of mice, adjust oxidative stress indexes, improve joint pathological injuries and regulate and control JAK2 / STAT3 pathway related protein expression, so that the effect of resisting rheumatoid arthritis is achieved.

The present invention relates to a thumb orthosis (10) for alleviating and / or treating rhizarthrosis comprising an extensible textile tubular member (12) comprising a dorsal hand portion (20), a palmar hand portion (30), a thumb-index finger notch portion (60) extending between first and second distal tubular portions (40, 50), a thin and reversibly bendable spacer member (70), extending, at least in part, along the thumb-index finger notch portion (60), a main return element (80) extending from the thumb-index finger notch portion (60) into the palmar hand portion (20) by covering and surrounding at least in part the base of the thumb joint (16) and extending into the dorsal hand portion (30) passing through the base of the thumb joint (16). The present invention also relates to a method of manufacturing such a thumb orthosis (10). Figure for abstract: Fig.1.

The utility model relates to the technical field related to arthropathy, and discloses an assisted joint recovery device for the department of rheumatism and immunology. The fixing assembly comprises a first fixing piece, a second fixing piece and a third fixing piece, the second fixing piece is arranged at the other end of the first connecting rod. The connecting piece is arranged on the connecting rod I; a movable assembly is further arranged on the fixed assembly, and the movable assembly comprises a sliding rail arranged on a second fixed part; when in use, the knee joint assisting device is fixed on a leg through the fixing assembly, the knee joint can be bent during walking, then the second connecting rod is driven to move downwards to compress the spring, and then the spring automatically rebounds after receiving pressure, so that the second connecting rod is driven again to move upwards, and the purpose of assisting a joint patient in walking is achieved. The problem that a traditional joint assisting recovery device does not have the function of assisting a patient in walking is solved, during daily rehabilitation training, bending training of knee joints can be completely exercised by means of the device, and the functionality and practicability of the device are greatly improved.