23 results about "Methylparaben" patented technology

The invention relates to the technical field of biology, and particularly discloses a recombinant collagen III and application thereof in preparation of gel. The recombinant collagen III is designed by optimizing functional area sequences of human I-type and III-type collagen, the amino acid sequence is shown as SEQ ID No.2, and the recombinant collagen III has the characteristics of high stability, good hydrophilicity and low immunogenicity. The preparation method comprises the steps of expression vector construction, escherichia coli induced expression, affinity chromatography purification and renaturation. The recombinant collagen III can be prepared into a gel dressing and comprises sodium alginate, methylparaben and other components. Experiments show that the gel can effectively promote cell proliferation and has no cytotoxicity; in a mouse skin injury model, the collagen can relieve inflammation, accelerate wound healing and inhibit scar formation, and the effect of the collagen is superior to that of natural human III-type collagen. The invention provides a safe and efficient novel material for wound repair, and is suitable for medical dressings and tissue engineering.

To provide a method for fixing carbon dioxide by which bubbles of carbon dioxide introduced into a solution can be made fine without increasing energy consumption.SOLUTION: A carbon dioxide fixation method comprising a precipitation step of introducing a gas containing carbon dioxide into a carbon dioxide fixation solution in which calcium ions are eluted to generate bubbles of the gas containing carbon dioxide in the carbon dioxide fixation solution, thereby reacting the calcium ions eluted in the carbon dioxide fixation solution with carbon dioxide to precipitate calcium carbonate, wherein the carbon dioxide fixation solution is an aqueous solution in which calcium ions are eluted in an aqueous solution of methylparaben.SELECTED DRAWING: Figure 1

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention provides a teak camel moth artificial feeding feed and a teak camel moth artificial feeding method, the feed comprises the following components by weight: 8% of wheat germ powder, 4% of soybean meal, 4% of yeast powder, 2% of casein, 2% of sucrose, 1.8% of agar powder, 1.5% of cellulose, 0.8% of Webster salt, 0.6% of vitamin C, 0.2% of sorbic acid, 0.3% of methyl p-hydroxybenzoate, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.01% of folic acid, and the balance of water. And the balance of deionized water. The invention further provides an artificial feeding method of teak camelmoths, and the artificial feeding method comprises the steps of 1, adult mating and egg laying, 2, egg disinfection and incubation and 3, larva rearing. The feed does not contain host material teak leaves, and full-artificial continuous large-scale feeding of the teak camelmoths can be achieved.

The invention provides a compound lithospermum erythrorhizon lip balm for improving chronic cheilitis, which is characterized by being prepared by adding methylparaben into the following raw materials: 6g of lithospermum erythrorhizon, 1g of angelica sinensis, 1g of divaricate saposhnikovia root, 1g of radix rehmanniae recen, 1g of liquorice, 1g of radix angelicae, 1g of frankincense, 1g of myrrh, 0.01 g of methylparaben, 0.1 g of vitamin E, 30g of beewax and 150mL of olive oil. The preparation method comprises the following steps: mixing Chinese angelica, divaricate saposhnikovia root, raw rehmannia root, licorice, dahurian angelica root, frankincense and myrrh, frying with olive oil to obtain medicinal oil A, adding lithospermum, heating, filtering, cooling the obtained medicinal oil B to 60 DEG C, adding vitamin E to obtain medicinal oil C, adding heated and melted beeswax, uniformly mixing, adding methylparaben, and pouring. The invention further provides application, and the prepared compound lithospermum erythrorhizon lip balm is used for improving chronic cheilitis. The compound lithospermum erythrorhizon lip balm for improving chronic cheilitis prepared by the invention can be used for improving chronic cheilitis, is safe and effective, and can relieve lip symptoms of chronic cheilitis.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

An oral liquid suspension comprising atomoxetine or a pharmaceutically acceptable salt thereof is disclosed, formulated at a concentration of about 20 mg / mL for the treatment of attention-deficit / hyperactivity disorder (ADHD). The suspension includes a dual preservative system (methylparaben and sodium benzoate), sweeteners, pH buffers, suspending agents, co-solvents, flavorants, and colorants. The composition demonstrates bioequivalence to Strattera® capsules, robust antimicrobial efficacy meeting USP <51> criteria, and physicochemical stability over 24 months in validated high-density polyethylene containers with child-resistant closures. The 20 mg / mL concentration enables precise dose titration for pediatric and dysphagic patients. Palatability is optimized through validated flavor masking studies, supporting high patient adherence. The invention further provides scalable manufacturing methods, quality control specifications, and methods of use for treating ADHD, offering a stable, safe, and patient-friendly alternative to solid oral dosage forms.

This invention relates to the fields of fine chemicals and polymer materials technology, specifically a method for manufacturing toy adhesives. It includes steps for preparing the adhesive base material, preparing borax solution, and cross-linking molding. Polyvinyl alcohol, guar gum, methylparaben, etc., are prepared as base materials, which are then reacted with borax solution to undergo a cross-linking reaction. The core of this invention is the strict limitation of specific high-temperature ranges and constant-temperature stirring times during the base material preparation process, which promotes the complete extension and entanglement of molecular chains, constructing a dense and uniform three-dimensional network structure. This invention effectively avoids microscopic particle residue and stress concentration, achieving a significant improvement in the tensile strength, elongation at break, and resilience of the toy adhesive.

The invention belongs to the technical field of pharmaceutical preparations, and provides a compound emulsifiable paste for inhibiting bacteria, relieving itching, diminishing inflammation and detoxifying and a preparation method of the compound emulsifiable paste. The compound cream is prepared from a water-phase raw material and an oil-phase raw material, the water-phase raw materials comprise ultramicro licorice powder, ultramicro alum powder, ultramicro mint powder, ultramicro borneol powder, glycerol, 1, 3-propylene glycol and xanthan gum; the oil phase raw materials comprise vegetable oil, vitamin E, methylparaben and vaseline. The compound emulsifiable paste has excellent effects of diminishing inflammation, relieving itching, inhibiting bacteria and detoxifying, has the characteristic of quick effect, and has a good treatment effect on mosquito bites (especially poisonous insect bites) and eczema; meanwhile, through compounding of specific auxiliary materials, the stability is further improved, and the storage life is effectively prolonged.

This application relates to the technical field of daily cosmetics, specifically disclosing a hair-repairing and conditioning wheat composition, a cosmetic containing the composition, and a preparation method thereof. The hair-repairing and conditioning composition comprises the following components in parts by weight: 0.003-0.006 parts of a mixture of hydrolyzed wheat protein / phenoxyethanol / methylparaben / ethylparaben / ethylhexylglycerin / propylene glycol / water; 0.03-0.05 parts of a mixture of wheat germ oil glycerides / glyceryl stearate; and 2.4-2.6 parts of a mixture of cationic surfactant / ethanol. The wheat germ oil glycerides selected in this application are rich in linoleic acid and vitamin E, exhibiting a stronger affinity for cationic surfactants, enabling the formation of a stable "cationic-oil complex" for efficient deposition. Simultaneously, the wheat germ oil glycerides are homologous to hydrolyzed wheat protein, forming a synergistic repair mechanism of first penetrating and filling, then sealing and locking in moisture, thus improving the hair-repairing and conditioning effect.

The invention belongs to the technical field of pigment red preparation, and particularly provides a high crystal transformation quality-based quinacridone pigment red surface treatment process, which comprises the following steps: 1) taking a pigment crude product, and carrying out grinding and salt milling to obtain a primary treatment material; and 2) adding a solvent and a MA-HBA derivative into the primary treatment material, stirring for pigmentation, and then filtering and drying to obtain the pigment red, the MA-HBA derivative is prepared by synthesizing methyl p-hydroxybenzoate and 1, 11-undecanediol, and the prepared pigment red has the advantages of good pigmentation effect and good covering power.

This invention provides a composition for treating dysmenorrhea due to cold in the uterus and relieving menstrual pain, and its preparation method, relating to the field of traditional Chinese medicine composition technology. The raw materials of this composition are: bergamot, oldenlandia diffusa, broom flower, evening primrose-morinda officinalis extract, mugwort, chuanxiong rhizome, angelica sinensis, astragalus, frankincense, myrrh, madder root, licorice, prepared rehmannia root, dried ginger, eucommia bark, peach kernel, safflower, Tween-80, sodium carboxymethyl cellulose, propylene glycol, methylparaben, and water. Through the synergistic effect of each component, it can regulate uterine smooth muscle contraction, relieve uterine smooth muscle spasms, improve blood rheology, effectively improve uterine microcirculation, help expel stagnant blood from the uterine cavity, and relieve menstrual pain. It has the effects of promoting blood circulation, removing blood stasis, regulating menstruation, relieving pain, replenishing qi and nourishing, and warming the middle jiao and dispelling cold, thus it can be used to treat dysmenorrhea due to cold in the uterus and relieve menstrual pain.

The invention discloses an intelligent medical coupling agent as well as a preparation method and application thereof, and belongs to the technical field of medical materials. Comprising the following steps: dissolving SiO2 nanoparticles in deionized water, adding an HPTS dye and gamma-aminopropyltriethoxysilane, purifying and concentrating to obtain a pH response nanoprobe; the preparation method comprises the following steps: dissolving dipalmitoyl phosphatidylcholine, dipalmitoyl phosphatidyl glycerol and a therapeutic drug in a chloroform-methanol mixed solvent, and evaporating and drying to obtain a lipid film; adding a PBS (Phosphate Buffer Solution) into the lipid film, introducing perfluoropropane, carrying out rotary shearing emulsification, and collecting micro-bubbles to obtain drug-loaded ultrasonic response micro-bubbles; the preparation method comprises the following steps: adding the carbomer powder into deionized water, and then adding glycerol, triethanolamine and methylparaben to obtain basic gel; adding a pH response nanoprobe into the basic gel, adding drug-loaded ultrasonic response microbubbles after the fluorescence intensity CV value is less than or equal to 5%, and performing multi-stage gradient vacuum treatment to obtain the intelligent medical coupling agent. The intelligent medical coupling agent provided by the invention realizes targeted delivery of drugs and physiological status feedback of tissues.

The invention discloses application of recombinant human glaze matrix protein in preparation of an anti-periodontitis oral care product. The oral care product is prepared from rhEMPs, glycerin, sorbitol, poloxamer 188, sodium lauroyl sarcosinate, potassium nitrate, sucralose, xylitol, methylparaben, propylene glycol, PEG-40 hydrogenated castor oil, domiphen and water. The core innovation of the oral care product is that the stability bottleneck of rhEMPs in the physiological pH environment of the oral care product is solved by utilizing the synergistic stabilization effect of poloxamer 188 and sodium lauroyl sarcosinate, and it is found that when the oral care product is combined with components such as potassium nitrate, periodontal pathogenic bacteria can be remarkably inhibited, gingival inflammation can be relieved, and periodontal tissue repair can be promoted. The product form can be mouth wash, oral spray or toothpaste, the preparation process is simple, the stability is good, and a brand new solution is provided for daily adjuvant therapy of periodontitis.

This invention relates to a gel preparation with pistachio shell extract as the active ingredient which has the effect of inhibiting Staphylococcus aureus bacteria. The gel consists of pistachio shell extract made from a maceration process using 70% alcohol, 5% CMC-Na gel base, 5.0% glycerin humectant, 3.0% propylene glycol, 0.25% methyl paraben preservative and aquades solvent added up to 100%. The gel has antibacterial activity which is characterized by the formation of an inhibition zone against Staphylococcus aureus bacteria. The emergence of this inhibition zone is due to the active compound contained in the gel base diffusing through the media so that it is able to inhibit the growth of Staphylococcus aureus bacteria. The positive control used in this antibacterial test is 1.2% clindamycin phosphate gel.From the results of the antibacterial effectiveness test that has been carried out, it was found that 10% to 25% pistachio shell extract gel can inhibit ≥15mm-24mm of Staphylococcus aureus bacterial growth with Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values ​​of 80% and 100%, respectively.

The present application belongs to the technical field of insect feeding, and provides a kind of artificial feed for small line angle wood borer larvae, and its preparation method and application.The artificial feeding special feed includes the following raw materials by weight: white waxwood shavings 90-110 parts, soybean powder 25-35 parts, corn flour 10-20 parts, agar powder 3-7 parts, sucrose 2-4 parts, yeast powder 2-4 parts, cholesterol 0.3-0.7 parts, potassium sorbate 0.3-0.7 parts, methyl paraben 0.3-0.7 parts, ascorbic acid 0.3-0.7 parts, soybean oil 3-7 parts, and water 90-110 parts.Through three months of feeding test, it is proved that the growth rate and weight gain of group B larvae are significantly better than those of other groups, and the growth state of the experimental group with added oil and fat is obviously better, which provides an efficient technical solution for the large-scale artificial feeding of small line angle wood borer larvae, and provides a stable insect source for related biological research and prevention and control technology development.

The invention discloses a thermosensitive phase splitting-annealing crystal form synergistic repair freeze-dried bubble composition, freeze-dried bubbles are composed of a solvent, polyol, active peptide, a plant extract, a preservative and an auxiliary agent, the solvent liquid contains water, methylparaben, sodium hyaluronate and allantoin; the preparation method comprises the following steps: dissolving the A-phase heat-resistant skeleton components (water, mannitol, hydrolyzed collagen and sodium hyaluronate) at 80 DEG C, cooling to 45 DEG C, and adding the B-phase heat-sensitive functional components (recombinant III-type human collagen, polypeptide, bifidus yeast, albiflorin and the like); the freeze-drying process comprises annealing treatment at-20 DEG C, and mannitol is induced to be crystallized into a stable delta crystal form; carrying out multi-stage stepped heating and slow analysis at 45 DEG C, and controlling the residual moisture to be 3-5%; according to the method disclosed by the invention, the conformation retention rate of the recombinant collagen is more than 90%, the redissolution time is less than 5 seconds, the cake blocks do not collapse in 24 months through the coordination of'skeleton-effect 'split-phase feeding and'annealing-stepped heating' processes, and the activity retention rate and the stability of the multi-component freeze-dried essence are remarkably improved.

This invention belongs to the field of medical materials technology and discloses a medical composite dressing for relieving dermatitis and eczema and its preparation method. First, mussel adhesive protein is dissolved in purified water, and the pH is adjusted to obtain a mussel adhesive protein solution. Trehalose, ectoine, and a portion of glycerin are mixed and dissolved to obtain an active ingredient composite solution. Then, the mussel adhesive protein solution and the active ingredient composite solution are mixed, and the pH is adjusted to obtain phase A. Sodium carboxymethyl cellulose is dissolved in a buffer solution in batches to obtain sodium carboxymethyl cellulose solution A and sodium carboxymethyl cellulose solution B. The two solutions are mixed, and the remaining glycerin and methylparaben are added. After adjusting the pH, phase B is obtained. Finally, phase A is added dropwise to phase B, stirred, and allowed to stand for maturation to obtain the final product. The medical composite dressing provided by this invention has a unique temperature-pH response mechanism, enabling the release of active ingredients such as ectoine and trehalose under weakly acidic conditions, achieving targeted repair and moisturizing of the inflamed area.

The invention provides a face cream and a preparation method thereof, belongs to the technical field of cosmetics, and aims to effectively repair a skin cutin barrier, effectively improve the skin hydration degree and delay skin aging. The face cream provided by the invention is prepared from the following raw materials in parts by weight: 5 to 10 parts of flaky microcapsules, 3 to 5 parts of jade additives, 5 to 10 parts of squalene microspheres, 4 to 6 parts of chitosan microneedles, 25 to 35 parts of lignin modified lipidosome, 1 to 3 parts of collagen, 1 to 3 parts of ceramide, 1 to 3 parts of hyaluronic acid, 1 to 3 parts of xanthan gum, 1 to 3 parts of carboxymethylcellulose, 2 to 4 parts of sodium isostearoyl lactylate, 1 to 2 parts of propylene glycol, 1 to 2 parts of ethylene glycol and 0.5 to 5 parts of lignin modified lipidosome. 1 part of phenoxyethanol, 0.5-1 part of methylparaben and 20-30 parts of deionized water. The face cream has a repairing effect on damaged cuticula, the problems of skin dryness and water shortage are solved, and skin aging is delayed.

The invention discloses sodium chlorite gel used as a disinfectant and a preparation process thereof, and belongs to the technical field of disinfectant preparation. The preparation process comprises the steps of mixed dispersion liquid preparation, silver complex dispersion liquid preparation, gel matrix solution preparation, mixing, acid adjustment, filling and the like. According to the process, a layered double-metal hydroxide intercalated silicotungstic acid compound is used as a sodium chlorite stable carrier, so that slow release of chlorine dioxide is realized; silver ions are loaded on amino phosphonic acid modified mesoporous silica to form a silver complex antibacterial component. The two functional components have a synergistic effect, so that the disinfection effect is enhanced. In the preparation process, the pH value of the system is controlled, sodium chlorite is prevented from being decomposed in advance, and the network structure is stable after gel forming. Calcium chloride is added to promote formation of a gel network of gellan gum, methylparaben and potassium sorbate synergistically prevent corrosion, and the shelf life of the product is prolonged. The sodium chlorite gel prepared by the invention has the advantages of broad-spectrum antibacterial property, sustained release and lasting effect, good stability, high safety and the like.

A topical antimicrobial gel composition consisting of an ethanolic extract of Anacyclus pyrethrum roots dispersed in a Carbopol 940 hydrogel, propylene glycol, glycerin, methylparaben, triethanolamine and distilled water, wherein the composition is adjusted to a skin-compatible pH and configured to provide spreadable, homogeneous gel properties.

To provide a grape sap which can stably be formulated in cosmetics and quasi-drugs by a prescription for suppressing the amount of a preservative to the minimum unlike a combination of an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol with a preservative, and to provide cosmetics and quasi-drugs formulated with the grape sap.SOLUTION: Without using an organic solvent such as 1, 3-butylene glycol, methyl p-hydroxybenzoate (methylparaben), ethyl p-hydroxybenzoate (ethylparaben) or phenoxyethanol, the preservability of the grape sap can be enhanced by the baked powder of the scallop and the plant extract having the antiseptic auxiliary action, and the grape sap can further stably be formulated with cosmetics and quasi-drugs.SELECTED DRAWING: None

The invention discloses a preparation method of eye herbal gel with an eye nursing function, and particularly relates to a medical nursing material. The preparation method comprises the following steps: preparing the carbomer matrix by using 60% deionized water under homogeneous shearing at the temperature of 5-25 DEG C and the speed of 400-500rpm; preparing a water phase and adding arginine to prepare a neutralization phase; then heating the carbomer matrix to 30-35 DEG C, adding the neutralizing phase, stirring at the rotating speed of 200-300rpm, and then adjusting the pH value to 5.8-6.0 to form transparent gel; pre-emulsifying the xanthophyll, cooling the gel to 25-30 DEG C, and then adding sodium hyaluronate, a fat-soluble component and a xanthophyll fat-soluble phase; and defoaming under vacuum of-0.08 to-0.09 MPa, and finally adding phenoxyethanol-methylparaben as a preservative. According to the method, the problems of caking and non-uniform dispersion are solved through phase separation, low temperature and pre-emulsification processes, and the biological activity of active ingredients is reserved. The product can relieve asthenopia, astigmatism and blurred vision.