58 results about "Methylparaben" patented technology

The invention relates to the technical field of biology, and particularly discloses a recombinant collagen III and application thereof in preparation of gel. The recombinant collagen III is designed by optimizing functional area sequences of human I-type and III-type collagen, the amino acid sequence is shown as SEQ ID No.2, and the recombinant collagen III has the characteristics of high stability, good hydrophilicity and low immunogenicity. The preparation method comprises the steps of expression vector construction, escherichia coli induced expression, affinity chromatography purification and renaturation. The recombinant collagen III can be prepared into a gel dressing and comprises sodium alginate, methylparaben and other components. Experiments show that the gel can effectively promote cell proliferation and has no cytotoxicity; in a mouse skin injury model, the collagen can relieve inflammation, accelerate wound healing and inhibit scar formation, and the effect of the collagen is superior to that of natural human III-type collagen. The invention provides a safe and efficient novel material for wound repair, and is suitable for medical dressings and tissue engineering.

To provide a method for fixing carbon dioxide by which bubbles of carbon dioxide introduced into a solution can be made fine without increasing energy consumption.SOLUTION: A carbon dioxide fixation method comprising a precipitation step of introducing a gas containing carbon dioxide into a carbon dioxide fixation solution in which calcium ions are eluted to generate bubbles of the gas containing carbon dioxide in the carbon dioxide fixation solution, thereby reacting the calcium ions eluted in the carbon dioxide fixation solution with carbon dioxide to precipitate calcium carbonate, wherein the carbon dioxide fixation solution is an aqueous solution in which calcium ions are eluted in an aqueous solution of methylparaben.SELECTED DRAWING: Figure 1

The invention relates to the technical field of wash supplies, and particularly discloses anti-hair loss essence and a preparation method thereof. The anti-hair-loss essence is prepared from the following raw materials in percentage by mass: 60-75% of water, 10-20% of ethanol, 1-3% of a cacumen biotae extract, 1-3% of an angelica root extract, 1-3% of a polygonum multiflorum root extract, 0.5-2% of a ganoderma atrum extract, 0.5-2% of a trollius chinensis bunge extract, 0.5-2% of a cultivated nigella glandulifera seed extract, 0.3-1% of a flat walnut seed extract, 0.1-0.5% of a radix sophorae flavescentis extract, 0.1-0.5% of chlorphenesin and 0.05-0.3% of methylparaben. The traditional Chinese medicine composition is prepared from the following components in percentage by weight: 0.01-0.20% of a ginseng extract, 0.01-0.20% of a selaginella tamariscina extract and 0.01-0.20 The anti-hair loss essence disclosed by the invention has the beneficial effects that the anti-hair loss essence adopts various natural plant extracts as main raw materials, the various natural plant extracts have a synergistic effect, the hair loss problem is comprehensively solved from multiple aspects of improving scalp blood circulation, nourishing hair follicles, regulating endocrine, resisting bacteria and diminishing inflammation and the like, and the anti-hair loss effect is remarkable.

The invention provides a detection method for related substances in loxoprofen sodium oral solution. The adopted ternary mobile phase system solves the interference of auxiliary materials in the low absorption band on the detection of known impurities, thereby avoiding the problem of missed detection and insufficient detection of impurities, effectively solving the interference of auxiliary material methylparaben on the detection of impurities when the related substances are determined, and the types and numbers of impurities to be monitored are large, the separation between various impurities, between impurities and main components, and between impurities and auxiliary materials is good, the related substances in the loxoprofen sodium oral solution can be quickly and accurately monitored, and the method has important significance for the quality evaluation of the loxoprofen sodium oral solution.

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention discloses a hydrogel patch for promoting blood circulation to remove meridian obstruction and a preparation method thereof. The formula of the hydrogel patch for promoting blood circulation to remove meridian obstruction comprises a traditional Chinese medicine concentrated solution for promoting blood circulation to remove meridian obstruction, an oil-in-water emulsion for promoting blood circulation to remove meridian obstruction, sodium polyacrylate, polyacrylic acid, glycerol, azone, dihydroxyaluminum aminoacetate, tartaric acid, disodium ethylene diamine tetraacetate, methylparaben and deionized water. The traditional Chinese medicine concentrated solution for promoting blood circulation to remove meridian obstruction is 70% ethanol extract of vinegar-processed rhizoma corydalis, ligusticum wallichii, philippine flemingia root, safflower, frankincense, myrrh, radix angelicae and liquorice; the oil-in-water emulsion capable of promoting blood circulation to remove meridian obstruction is prepared from a vinegar rhizoma corydalis sesame oil extract, wintergreen oil, methyl glucose sesquistearate, stearate, cetostearyl alcohol, polydimethylsiloxane and deionized water; the blood-activating collateral-dredging hydrogel patch has no skin irritation, belongs to weak sensitization, and has the function of assisting in relieving pain.

The invention provides a teak camel moth artificial feeding feed and a teak camel moth artificial feeding method, the feed comprises the following components by weight: 8% of wheat germ powder, 4% of soybean meal, 4% of yeast powder, 2% of casein, 2% of sucrose, 1.8% of agar powder, 1.5% of cellulose, 0.8% of Webster salt, 0.6% of vitamin C, 0.2% of sorbic acid, 0.3% of methyl p-hydroxybenzoate, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.01% of folic acid, and the balance of water. And the balance of deionized water. The invention further provides an artificial feeding method of teak camelmoths, and the artificial feeding method comprises the steps of 1, adult mating and egg laying, 2, egg disinfection and incubation and 3, larva rearing. The feed does not contain host material teak leaves, and full-artificial continuous large-scale feeding of the teak camelmoths can be achieved.

An oral liquid suspension comprising atomoxetine or a pharmaceutically acceptable salt thereof is disclosed, formulated at a concentration of about 20 mg / mL for the treatment of attention-deficit / hyperactivity disorder (ADHD). The suspension includes a dual preservative system (methylparaben and sodium benzoate), sweeteners, pH buffers, suspending agents, co-solvents, flavorants, and colorants. The composition demonstrates bioequivalence to Strattera® capsules, robust antimicrobial efficacy meeting USP <51> criteria, and physicochemical stability over 24 months in validated high-density polyethylene containers with child-resistant closures. The 20 mg / mL concentration enables precise dose titration for pediatric and dysphagic patients. Palatability is optimized through validated flavor masking studies, supporting high patient adherence. The invention further provides scalable manufacturing methods, quality control specifications, and methods of use for treating ADHD, offering a stable, safe, and patient-friendly alternative to solid oral dosage forms.

The invention discloses a medical recombinant collagen repair liquid preparation method, which is prepared from the following raw materials by weight: 1-100 g of recombinant collagen, 1-100 g of sodium hyaluronate, 1-100 g of glycerol, 1-100 g of purified water, and 1-10 g of methylparaben. The medical recombinant collagen repair liquid can effectively repair skin barriers and treat skin injuries caused by multiple reasons such as burns, wounds and laser postoperations, and meanwhile, the medical recombinant collagen repair liquid has remarkable advantages in the fields of gynecological inflammation treatment, private anti-aging, micro-ecological balance maintenance, wound healing promotion, tissue elasticity and compactness improvement and the like. Adverse reactions such as allergy are effectively reduced, and the requirements of people for high efficiency and safety of skin repairing products are met.

The present invention relates to the field of sewage treatment technology, and more particularly to a long-lasting antibacterial deodorant for sewage and a preparation method thereof. The long-lasting antibacterial deodorant for sewage is prepared from raw materials comprising the following components in parts by weight: 0.2-0.3 parts of 1,2-benzisothiazolin-3-one, 0.3-0.5 parts of p-tert-amylphenol, 0.1-0.2 parts of methyl parahydroxybenzoate, 4-6 parts of activated carbon, 4-6 parts of modified sustained-release microspheres, 8-12 parts of a modified polymer, and 2-3 parts of modified lysozyme.

The present application discloses a method for preparing a brivaracetam solution and the brivaracetam solution thereof, belonging to the field of medical technology. The method for preparing the brivaracetam solution comprises the following steps: (1) preparing solution 1: mixing a mixture including sodium carboxymethylcellulose and glycerol with purified water and stirring to obtain solution 1; (2) preparing solution 2: mixing purified water, methylparaben, sodium malate, malic acid, sucralose, crystalline sorbitol solution, brivaracetam, and glycerol and stirring to obtain an intermediate solution, mixing the intermediate solution with essence and stirring to obtain solution 2; (3) mixing solution 1, solution 2 and purified water, stirring, and filtering to obtain a brivaracetam solution. The method improves the clarity of the solution by controlling the order and temperature of addition of each auxiliary material, and the obtained brivaracetam solution has good stability and is free of precipitation and degradation impurities.

The disclosure relates to methods for amplifying a target nucleic acid. The methods include performing an amplifying step comprising contacting the nucleic acid with a polymerase, dNTPs, one or more set of primers specific for the nucleic acid, and an amplification enhancer that is methyl paraben or a derivative thereof. Also described are kits and reaction mixtures for the amplification of a target nucleic acid in the presence of the amplification enhancer, as well as methods for enhancing nucleic acid amplification.

The invention provides a compound lithospermum erythrorhizon lip balm for improving chronic cheilitis, which is characterized by being prepared by adding methylparaben into the following raw materials: 6g of lithospermum erythrorhizon, 1g of angelica sinensis, 1g of divaricate saposhnikovia root, 1g of radix rehmanniae recen, 1g of liquorice, 1g of radix angelicae, 1g of frankincense, 1g of myrrh, 0.01 g of methylparaben, 0.1 g of vitamin E, 30g of beewax and 150mL of olive oil. The preparation method comprises the following steps: mixing Chinese angelica, divaricate saposhnikovia root, raw rehmannia root, licorice, dahurian angelica root, frankincense and myrrh, frying with olive oil to obtain medicinal oil A, adding lithospermum, heating, filtering, cooling the obtained medicinal oil B to 60 DEG C, adding vitamin E to obtain medicinal oil C, adding heated and melted beeswax, uniformly mixing, adding methylparaben, and pouring. The invention further provides application, and the prepared compound lithospermum erythrorhizon lip balm is used for improving chronic cheilitis. The compound lithospermum erythrorhizon lip balm for improving chronic cheilitis prepared by the invention can be used for improving chronic cheilitis, is safe and effective, and can relieve lip symptoms of chronic cheilitis.

The invention relates to the technical field of intelligent production of cosmetics, and discloses an intelligent optimization-based body lotion preparation method and a product, the preparation method comprises the following steps: adding a first raw material group, PEG-100 stearate and the like into an oil phase pot, stirring and heating to 80 DEG C; adding water into an emulsifying pot, then sequentially adding the second raw material group, methylparaben and EDTA disodium, stirring and heating, then pouring an oil phase material into the emulsifying pot, collecting current particle size information of particles to determine an initial homogenizing parameter, comparing with historical particle size information to calculate similarity, and judging whether to adjust the parameter or not according to the maximum similarity to obtain a final homogenizing parameter. After homogenizing, keeping the temperature and stirring, adding dipotassium glycyrrhizinate, vacuumizing and keeping the temperature for 20 minutes; cooling to 45 DEG C, adding phenoxyethanol, stirring for 10 minutes, cooling to 35 DEG C or below, filtering, and taking a solid phase to obtain the body lotion. Through precise parameter control and a dynamic adjustment mechanism, the production process of the body lotion is optimized, and the raw material mixing uniformity and the particle stability are improved.

The invention relates to the technical field of skin care products, in particular to a preparation method of sunscreen cream. The preparation method of the sunscreen cream comprises the following steps: step 1, respectively selecting a proper amount of rhodiola rosea, polygonum cuspidatum, roses and green tea, crushing, and then respectively adding 70% ethanol with a solid-liquid ratio of 8-15 times to the rhodiola rosea, the polygonum cuspidatum, the roses and the green tea; step 2, taking a rhodiola rosea extracting solution, a polygonum cuspidatum extracting solution, a rose extracting solution and a green tea extracting solution as plant compound solutions; 3, preparing a proper amount of 1% sodium ethylene diamine tetracetate solution as a water phase; 4, selecting a proper amount of titanium dioxide, stearic acid, C16-C18 alcohol, vaseline, olive oil, methylparaben and the plant compound liquid as raw materials, heating in a water bath, stirring to form an oil phase, and then adding the mixed emulsifier; step five, adding the oil phase into the water phase while stirring, and then carrying out homogeneous emulsification by using a homogenizer; and 6, carrying out thermal insulation emulsification for 20 min, cooling to 50 DEG C, adding essence, fully stirring, cooling to room temperature (25 DEG C), stopping stirring, and carrying out discharging and filling.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

The present invention belongs to the field of personal care, and particularly relates to a glycoside derivative flexible liposome, a preparation method and an application thereof. The glycoside derivative flexible liposome comprises a main shell material, a humectant, a raw material to be encapsulated, an auxiliary shell material, a preservative and a solvent. The main shell material is phosphatidylcholine, and the auxiliary shell material is polyquaternium-51. The preservative is any one or more of 1,2-hexanediol, p-hydroxyacetophenone, methylparaben, phenoxyethanol, and caprylyl glycol. The humectant is butanediol. The raw material to be encapsulated is hydroxypropyltetrahydrofurantriol. The solvent is deionized water. The present invention uses a flexible liposome encapsulation technology to improve the permeability and penetration depth of boswellia serrata extract and its concentration at the target site, improve the bioavailability of boswellia serrata extract, reduce the addition amount under the condition of achieving the same firming and anti-wrinkle effect, and thus reduce the cost.

An oral liquid suspension comprising atomoxetine or a pharmaceutically acceptable salt thereof is disclosed, formulated at a concentration of about 20 mg / mL for the treatment of attention-deficit / hyperactivity disorder (ADHD). The suspension includes a dual preservative system (methylparaben and sodium benzoate), sweeteners, pH buffers, suspending agents, co-solvents, flavorants, and colorants. The composition demonstrates bioequivalence to Strattera® capsules, robust antimicrobial efficacy meeting USP <51> criteria, and physicochemical stability over 24 months in validated high-density polyethylene containers with child-resistant closures. The 20 mg / mL concentration enables precise dose titration for pediatric and dysphagic patients. Palatability is optimized through validated flavor masking studies, supporting high patient adherence. The invention further provides scalable manufacturing methods, quality control specifications, and methods of use for treating ADHD, offering a stable, safe, and patient-friendly alternative to solid oral dosage forms.

The invention belongs to the technical field of medicine, and particularly relates to poloxamer hydrogel for treating haemorrhoids, the main component of the hydrogel is poloxamer, the content of the poloxamer is 2.5-3.5%, and the hydrogel can further contain carbomer, edetate disodium, glycerol, triethanolamine and methylparaben, and the haemorrhoids hydrogel is remarkable in curative effect, small in irritation and free of toxic and side effects. The traditional Chinese medicine composition can be used for treating symptoms such as anal falling swelling pain, mucosa hyperemia and hematochezia caused by internal hemorrhoids, external hemorrhoids and mixed hemorrhoids.

The invention provides an HPLC (High Performance Liquid Chromatography) detection method of adapalene gel and application thereof, and particularly relates to the technical field of analysis and detection of medicinal components. The HPLC detection method of the adapalene gel is used for simultaneously detecting the contents of adapalene, methylparaben and phenoxyethanol in the adapalene gel; according to the HPLC detection method, a mixed solution of a mobile phase A and a mobile phase B is used as a mobile phase, and a sample solution to be detected is subjected to gradient elution; the initial volume ratio of the mobile phase A to the mobile phase B is (78-82): (22-18); in the gradient elution, the volume ratio of the mobile phase A to the mobile phase B is from (78-82): (22-18) to (28-32): (72-68) and finally returns to (78-82): (22-18). The detection method is simple and can be used for simultaneously determining the contents of adapalene, methylparaben and phenoxyethanol.

The invention discloses essence containing mint and chrysanthellum indicum rose essential oil, the essence comprises a liquid part and an oil body part, the liquid part comprises water, propylene glycol, butanediol, glycerol, tremella fuciformis seed extract, triethanolamine, methylparaben, carbomer, xanthan gum and trace components; the oil body part is prepared from cyclomethicone, polydimethylsiloxane, vanillyl butyl ether and rose oil. The trace components comprise capryloyl hydroximic acid, glycerol caprylate, sodium polyacrylate, a chrysanthellum indicum extract, a mint extract, a portulaca oleracea flower / leaf / stem extract, a pelargonium graveolens extract, sodium hyaluronate, lactose, hydroxypropyl methyl cellulose, tocopheryl acetate, ascorbyl palmitate, CI 77007, an aloe barbadensis leaf extract and a radix sophorae flavescentis extract.

This invention relates to the fields of fine chemicals and polymer materials technology, specifically a method for manufacturing toy adhesives. It includes steps for preparing the adhesive base material, preparing borax solution, and cross-linking molding. Polyvinyl alcohol, guar gum, methylparaben, etc., are prepared as base materials, which are then reacted with borax solution to undergo a cross-linking reaction. The core of this invention is the strict limitation of specific high-temperature ranges and constant-temperature stirring times during the base material preparation process, which promotes the complete extension and entanglement of molecular chains, constructing a dense and uniform three-dimensional network structure. This invention effectively avoids microscopic particle residue and stress concentration, achieving a significant improvement in the tensile strength, elongation at break, and resilience of the toy adhesive.

The preparation method specifically comprises the following steps: step 1, adding 2-4 parts of sodium isostearoyl lactylate, 1-2 parts of propylene glycol, 1-2 parts of ethylene glycol, 1-3 parts of xanthan gum, 1-3 parts of carboxymethyl cellulose and 15-25 parts of lecithin into an oil phase pot, stirring and heating, and uniformly mixing to obtain an oil phase; 2, 1-3 parts of collagen, 1-3 parts of ceramide, 1-3 parts of hyaluronic acid, 5-10 parts of bamboo charcoal adsorption nano silver and 20-30 parts of deionized water are added into a water phase pot, heating and heat preservation are conducted, and uniform stirring is conducted to obtain a water phase; 3, adding the oil phase and the water phase into an emulsifying pot, heating, stirring and homogenizing; and step 4, reducing the temperature in the emulsifying pot, adding 25-35 parts of compound essential oil nanocapsules, 0.5-1 part of phenoxyethanol and 0.5-1 part of methylparaben, uniformly stirring and mixing, and cooling to obtain the acne-removing moisturizing lotion.

The invention belongs to the technical field of pharmaceutical preparations, and provides a compound emulsifiable paste for inhibiting bacteria, relieving itching, diminishing inflammation and detoxifying and a preparation method of the compound emulsifiable paste. The compound cream is prepared from a water-phase raw material and an oil-phase raw material, the water-phase raw materials comprise ultramicro licorice powder, ultramicro alum powder, ultramicro mint powder, ultramicro borneol powder, glycerol, 1, 3-propylene glycol and xanthan gum; the oil phase raw materials comprise vegetable oil, vitamin E, methylparaben and vaseline. The compound emulsifiable paste has excellent effects of diminishing inflammation, relieving itching, inhibiting bacteria and detoxifying, has the characteristic of quick effect, and has a good treatment effect on mosquito bites (especially poisonous insect bites) and eczema; meanwhile, through compounding of specific auxiliary materials, the stability is further improved, and the storage life is effectively prolonged.

The invention discloses an I-type recombinant collagen gel dressing as well as a preparation method and application thereof. The dressing comprises the following main components: sodium alginate, I-type recombinant collagen and methylparaben. The preparation method comprises the following steps: sequentially or simultaneously weighing the main components in parts by weight, adding a weakly acidic phosphate buffer solution, stirring and dissolving by using a stirrer to form I-type recombinant collagen gel, centrifugally defoaming, sterilizing, filling and storing at normal temperature. The I-type recombinant collagen gel dressing has the advantages of simple and easily available raw materials, few steps of the preparation method, simple operation, no hormone and heavy metal, no toxicity and no irritation, can be directly taken and coated on a wound surface, and can also be ground into powder for use after freeze drying, or the powder is taken and processed into a solid filler for use, so that the wound is promoted to be quickly healed and repaired within 20 days, and the wound healing effect is good. The generation of scars is inhibited. The gel dressing can be applied to various skin wounds or in-vivo mucous membrane surfaces.

This application relates to the technical field of daily cosmetics, specifically disclosing a hair-repairing and conditioning wheat composition, a cosmetic containing the composition, and a preparation method thereof. The hair-repairing and conditioning composition comprises the following components in parts by weight: 0.003-0.006 parts of a mixture of hydrolyzed wheat protein / phenoxyethanol / methylparaben / ethylparaben / ethylhexylglycerin / propylene glycol / water; 0.03-0.05 parts of a mixture of wheat germ oil glycerides / glyceryl stearate; and 2.4-2.6 parts of a mixture of cationic surfactant / ethanol. The wheat germ oil glycerides selected in this application are rich in linoleic acid and vitamin E, exhibiting a stronger affinity for cationic surfactants, enabling the formation of a stable "cationic-oil complex" for efficient deposition. Simultaneously, the wheat germ oil glycerides are homologous to hydrolyzed wheat protein, forming a synergistic repair mechanism of first penetrating and filling, then sealing and locking in moisture, thus improving the hair-repairing and conditioning effect.

The present invention discloses a triamcinolone acetonide and econazole nitrate cream, which comprises an aqueous phase and an oil phase. The aqueous phase matrix is one or more of polyoxyethylene castor oil, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, polyoxyethylene oleyl alcohol, polyoxyethylene fatty alcohol, and polyoxyethylene methyl stearate; the oil phase matrix is one or more of isooctyl palmitate, isooctyl stearate, isopropyl palmitate, and dimethyl polysiloxane; it also contains an antibacterial agent, which is one or more of methylparaben and ethylparaben. The present invention also discloses a preparation method thereof. Experimental studies have proved that the quality of the present invention is stable.

The invention discloses activating essence cream containing centella asiatica, ginseng and polygonum cuspidatum extracts and a preparation method of the activating essence cream. Essence cream comprises water, mineral oil, glycerin, ethylhexyl isopalmitate, hydrogenated polydecene, butanol polyether-2, butanediol, caprylic / capric triglyceride, cetostearyl alcohol, stearic acid, glyceryl stearate, stearate, polydimethylsiloxane, cetostearyl alcohol polyether-25, polysorbate-80, methylparaben, allantoin, carbomer, triethanolamine, essence and bis (hydroxymethyl). Imidazolidinyl urea and trace components. The activating essence cream disclosed by the invention contains various active ingredients, such as plant extracts, with the effects of repairing, resisting oxidation, moisturizing, tightening and the like. The components can go deep into the bottom layer of the skin, promote metabolism of cells, accelerate the self-repairing ability of the skin, improve the moisturizing ability and elasticity of the skin, reduce the generation of fine wrinkles and wrinkles, and make the skin smoother, tighter and more elastic.

The invention is suitable for the technical field of organic synthesis, and provides a 4-(4-phenylbutoxy) methyl benzoate synthesis method, which comprises the following steps: S1, adding methyl parahydroxybenzoate and 1-bromo-3-chloropropane into a solvent, adding inorganic alkali in batches, then carrying out a heat preservation reaction, and after the reaction is finished, carrying out reduced pressure distillation to obtain 4-(4-phenylbutoxy) methyl benzoate; recovering the solvent, adding water for quenching, extracting with methylbenzene, washing with water to obtain a 4-(3-chloropropoxy) methyl benzoate methylbenzene solution, and then directly entering the next procedure; and S2, under the protection of nitrogen, mixing the 4-(3-chloropropoxy) methyl benzoate toluene solution, phenethyl boric acid, a catalyst, alkali and a solvent for reaction, and performing coupling to obtain the 4-(4-phenylbutoxy) methyl benzoate. According to the method, palladium is used for catalyzing coupling, Grignard reaction and Friedel-Crafts reaction are avoided, blue-green copper ion waste water is avoided, a large amount of acid waste water generated by using aluminum trichloride is also avoided, the method is environmentally friendly, the synthesis route is simple, the yield of each step is high, and the preparation cost of the p-phenylbutoxybenzoic acid is reduced.

The present invention relates to the technical field of zinc oxide foam, and a kind of zinc oxide foam and preparation method thereof is provided.The zinc oxide foam comprises the following raw materials: isobutane, zinc oxide, 1,2-butylene glycol, polydimethylsiloxane, caprylic acid / capric acid triglyceride, steareth-21, cetearyl alcohol, glycerol, D-panthenol, sunflower seed oil, propane, steareth-2, hydroxypropyl methylcellulose, parahydroxyacetophenone, 1,2-hexanediol, 1,3-propylene glycol, marigold extract, phenoxyethanol, methylparaben and water.The zinc oxide foam of the present invention has lower foam density and higher foam stability, has good ultraviolet protection effect, and can absorb skin grease, regulate skin microenvironment, and contribute to wound healing.At the same time, due to the characteristics of its foam formulation, it can be easy to use, evenly distributed, will not leave obvious white residue on the skin, and provides a pleasant sensory experience.