Compound lithospermum lip balm for improving chronic cheilitis as well as preparation method and application of compound lithospermum lip balm

Abstract

The invention provides a compound lithospermum erythrorhizon lip balm for improving chronic cheilitis, which is characterized by being prepared by adding methylparaben into the following raw materials: 6g of lithospermum erythrorhizon, 1g of angelica sinensis, 1g of divaricate saposhnikovia root, 1g of radix rehmanniae recen, 1g of liquorice, 1g of radix angelicae, 1g of frankincense, 1g of myrrh, 0.01 g of methylparaben, 0.1 g of vitamin E, 30g of beewax and 150mL of olive oil. The preparation method comprises the following steps: mixing Chinese angelica, divaricate saposhnikovia root, raw rehmannia root, licorice, dahurian angelica root, frankincense and myrrh, frying with olive oil to obtain medicinal oil A, adding lithospermum, heating, filtering, cooling the obtained medicinal oil B to 60 DEG C, adding vitamin E to obtain medicinal oil C, adding heated and melted beeswax, uniformly mixing, adding methylparaben, and pouring. The invention further provides application, and the prepared compound lithospermum erythrorhizon lip balm is used for improving chronic cheilitis. The compound lithospermum erythrorhizon lip balm for improving chronic cheilitis prepared by the invention can be used for improving chronic cheilitis, is safe and effective, and can relieve lip symptoms of chronic cheilitis.

Description

Technical Field

[0001] This invention belongs to the field of lip balm technology, specifically relating to a compound comfrey lip balm for improving chronic cheilitis, its preparation method, and its application. Background Technology

[0002] Chronic cheilitis primarily refers to long-term inflammatory changes in the skin of the lips. Clinically, patients with chronic cheilitis often present with dry, flaky, and cracked lips, sometimes accompanied by pain and itching. According to the clinical symptoms of cheilitis in traditional Chinese medicine, it is quite similar to "lip wind disease" in TCM, characterized by redness, swelling, itching, pain, cracking, oozing, dryness, and flaking of the lips. Its syndrome falls under the categories of "lip wind" and "lip swelling," with a mixed pattern of deficiency and excess: excess is due to wind, fire, dampness, and heat, resulting in severe redness, swelling, itching, ulceration, and pain; deficiency is due to yin deficiency and blood dryness, resulting in red, dry, cracked lips with oozing and crusting. Internal treatment is the primary approach, supplemented by external treatment.

[0003] Currently, medications and lip balms for chronic cheilitis are not entirely effective, and some patients experience allergic reactions to their chemical ingredients. Therefore, finding a safe and effective herbal lip balm is of great significance for improving the quality of life for patients with chronic cheilitis. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to address the shortcomings of the prior art by providing a compound comfrey lip balm for improving chronic cheilitis, its preparation method and application. This compound comfrey lip balm can be used to improve chronic cheilitis safely and effectively, and relieve its lip symptoms.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a compound comfrey lip balm for improving chronic cheilitis, which is made by adding methylparaben to the following ingredients in the following proportions: 6g comfrey, 1g angelica, 1g saposhnikovia, 1g rehmannia, 1g licorice, 1g angelica dahurica, 1g frankincense, 1g myrrh, 0.01g methylparaben, 0.1g vitamin E, 30g beeswax, and 150mL olive oil.

[0006] Preferably, the amount of methylparaben added is ≤0.1% mg / mL, i.e. ≤0.1% (w / v).

[0007] This invention also provides a method for preparing the above-mentioned compound comfrey lip balm for improving chronic cheilitis, the method being: S1. After mixing Angelica sinensis, Saposhnikovia divaricata, Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica dahurica, Boswellia carterii and Commiphora myrrha, a mixture is obtained; S2. After heating the olive oil at 110°C, add it to the mixture obtained in S1, fry it, filter the residue, and obtain medicinal oil A. S3. Add Lithospermum erythrorhizon to the medicinal oil A obtained in S2, heat it at a temperature of 160℃, filter the residue, and obtain medicinal oil B. S4. Cool the medicinal oil B obtained in S3 naturally to 60°C, then add vitamin E and methylparaben, stir to dissolve, and obtain medicinal oil C; S5. After heating and melting the beeswax, add it to the medicinal oil C obtained in S4. Mix it evenly at a temperature of 70°C. Then add methylparaben and mix it evenly. Pour the mixture into lipstick tubes and cool it at room temperature until the balm solidifies to obtain a compound comfrey lip balm for improving chronic cheilitis.

[0008] Preferably, the heating time in S2 is 20 minutes.

[0009] Preferably, the frying time in S2 is 30 minutes.

[0010] Preferably, the heating time in S3 is 20 minutes.

[0011] The present invention also provides the application of the above-mentioned compound comfrey lip balm for improving chronic cheilitis, wherein the compound comfrey lip balm is used to improve chronic cheilitis.

[0012] Compared with the prior art, the present invention has the following advantages: 1. The compound comfrey lip balm prepared in this invention is used to improve chronic cheilitis, mainly referring to long-term inflammatory changes in the lip skin. Clinically, patients with chronic cheilitis often present with dry, peeling, and cracked lips, sometimes accompanied by pain and itching. According to the clinical syndrome characteristics of cheilitis in traditional medicine, cheilitis is quite similar to "lip wind disease" in traditional Chinese medicine, a disease characterized by redness, swelling, itching, pain, cracking, oozing, dryness, and peeling of the lips. Its syndrome falls under the categories of "lip wind" and "lip swelling," with a mixed pattern of deficiency and excess: excess is due to wind, fire, dampness, and heat, with severe redness, swelling, itching, ulceration, and pain; deficiency is due to yin deficiency and blood dryness, with red, dry, cracked lips, oozing, and crusting.

[0013] In this formula, Lithospermum erythrorhizon is used as the principal ingredient. It has the functions of cooling the blood and detoxifying, directly targeting the root cause of inflammation, and can clear heat and detoxify, moisten dryness and promote tissue regeneration. In traditional Chinese medicine, the core pathogenesis of inflammation is often "internal accumulation of heat toxins" (such as redness, swelling, heat and pain) or "blood heat stagnation" (such as prolonged inflammation and local tissue damage). Lithospermum erythrorhizon is cold in nature and can directly clear heat toxins from the blood, relieving "heat" (redness, swelling, heat and pain) from the root cause; its "blood-activating" effect can dredge local stagnant qi and blood, improve blood circulation disorders caused by inflammation, and promote the discharge of pathological products (such as pus and inflammatory exudates); its "swelling reduction and tissue regeneration" can repair inflammatory damaged tissues and accelerate healing, which is the core force in improving inflammation.

[0014] Angelica sinensis, as an assistant herb, assists in promoting blood circulation and unblocking collaterals, enhancing the efficacy of the principal herb. In this formula, while Lithospermum erythrorhizon can cool and promote blood circulation, its cold nature can easily cause blood stagnation. Angelica sinensis, being pungent and warm, can promote blood circulation, enhancing the blood-activating and collateral-unblocking power of Lithospermum erythrorhizon, preventing excessive cooling of the blood from causing local blood stagnation. Simultaneously, its blood-activating and pain-relieving effects can directly alleviate pain caused by inflammation, complementing the blood-cooling and swelling-reducing effects of Lithospermum erythrorhizon, preventing excessive coldness from damaging the local yang qi of the cheilitis. This provides a material basis for inflammation healing while avoiding recurrence of inflammation due to "treating the pathogenic factors and harming the body's resistance."

[0015] Traditional Chinese medicine believes that "wind evil is prone to movement and change," and cheilitis, as a skin inflammation, is easily aggravated by external wind invasion. Therefore, this formula uses five herbs as adjuvants: Saposhnikovia divaricata, Rehmannia glutinosa, Angelica dahurica, Boswellia carterii, and Commiphora myrrha. Among them, Saposhnikovia divaricata, with its pungent and dispersing properties, can "dispel wind," clearing away wind evil attached to the affected area and preventing the spread of inflammation or itching and discomfort caused by wind evil; its "dampness-clearing" effect can also alleviate the "dampness evil" accompanying inflammation (such as purulent exudation and increased local secretions induced by cheilitis), assisting the principal and assistant herbs in clearing pathological products. Rehmannia glutinosa, being cold in nature, can assist Lithospermum erythrorhizon in strengthening the "blood-cooling" power, further clearing heat toxins from the blood in cases of "severe heat toxin" in inflammation (such as obvious redness and swelling, and strong burning sensation). Angelica dahurica can reduce swelling and drain pus. When cheilitis develops into a suppurative inflammation, Angelica dahurica can promote the drainage of pus and prevent pus accumulation from aggravating the inflammation. At the same time, its pungent and warm properties can enhance the wind-dispelling power of Saposhnikovia divaricata, and its analgesic effect directly relieves inflammatory pain, especially for local swelling and stinging pain. Frankincense and myrrh are used together to enhance the effects of promoting blood circulation and relieving pain. Both are warm in nature and can balance the cold nature of Lithospermum erythrorhizon and Rehmannia glutinosa, preventing the overall formula from being too cold and causing slow local tissue repair. Detailed Implementation

[0016] Example 1 The compound comfrey lip balm for improving chronic cheilitis in this embodiment is made by adding methylparaben to the following ingredients in the following proportions: 6g comfrey, 1g angelica, 1g saposhnikovia, 1g rehmannia, 1g licorice, 1g angelica dahurica, 1g frankincense, 1g myrrh, 0.01g methylparaben, 0.1g vitamin E, 30g beeswax, and 150mL olive oil.

[0017] In this embodiment, the amount of methylparaben added should be ≤0.1%mg / mL.

[0018] This embodiment also provides a method for preparing the compound comfrey lip balm for improving chronic cheilitis as described in the claims, the method being: S1. After mixing Angelica sinensis, Saposhnikovia divaricata, Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica dahurica, Boswellia carterii and Commiphora myrrha, a mixture is obtained; S2. After heating the olive oil at 110℃ for 20 minutes, add it to the mixture obtained in S1. Fry for 30 minutes until the angelica turns brownish-yellow. Filter the residue to obtain medicinal oil A. S3. Add Lithospermum erythrorhizon to the medicinal oil A obtained in S2, heat at 160℃ for 20 minutes, filter the residue, and obtain medicinal oil B. S4. Cool the medicinal oil B obtained in S3 naturally to 60°C, then add vitamin E and methylparaben, stir to dissolve, and obtain medicinal oil C; S5. After heating and melting the beeswax, add it to the medicinal oil C obtained in S4. Mix it evenly at a temperature of 70°C. Then add methylparaben and mix it evenly. Pour the mixture into lipstick tubes and cool it at room temperature until the balm solidifies to obtain a compound comfrey lip balm for improving chronic cheilitis.

[0019] The application of the compound comfrey lip balm prepared in this embodiment for improving chronic cheilitis is characterized by its use in improving chronic cheilitis. This embodiment also includes testing experiments to assess the efficacy and safety of the compound comfrey lip balm. This study observed the toxicity, skin irritation, and allergic reactions of compound comfrey lip balm in animals through experiments. It verified the efficacy and safety of compound comfrey lip balm in treating chronic cheilitis, revealed its mechanism of action in treating chronic cheilitis, opened up more avenues for traditional Chinese medicine treatment of chronic cheilitis, and provided a scientific basis for the clinical application of compound comfrey lip balm.

[0020] A randomized, single-blind, controlled study was conducted on patients with chronic cheilitis who met the inclusion criteria. The observation period was 3 weeks, and the recurrence rate was followed up 1 month after the end of treatment. The efficacy difference between compound comfrey lip balm and conventional treatment in patients with chronic cheilitis was compared and analyzed to quantitatively assess the degree of improvement of lip symptoms in patients with chronic cheilitis by compound comfrey lip balm.

[0021] (I) Experimental Methods 1. ICP-MS detection According to the requirements of the Cosmetic Safety Technical Specifications, the detection limits for heavy metal content in cosmetics are as follows: mercury must not exceed 1 mg / kg, arsenic must not exceed 10 mg / kg, lead must not exceed 2 mg / kg, and cadmium must not exceed 5 mg / kg.

[0022] Weigh an appropriate amount of sample (accurate to 0.0001 g) into the microwave digestion vessel. Add 1 mL of water to the sample, moisten and shake well. Add 5 mL of nitric acid and let stand overnight to allow for complete digestion. Add 1 mL of hydrogen peroxide and heat at 100°C for 30 min in an adjustable thermostatic heater. Remove from heat, cool, and seal. Digest according to the microwave digestion program. After complete digestion, cool and remove the digest. Heat the digest on a 100°C thermostatic heater for several minutes, cool, and bring to volume. Shake well before analysis. Prepare a reagent blank solution using the same method. Use ICP-MS to determine whether the contents of mercury, arsenic, lead, and cadmium meet the standards.

[0023] Table 1. Heavy metal detection report of the compound comfrey lip balm prepared in this embodiment. As shown in Table 1, the content of mercury, arsenic, lead and cadmium in the compound comfrey lip balm prepared in this experiment meets the standards.

[0024] 2. Animal experiments: Refer to the experimental methods for skin irritation and allergy testing in the "Guidelines for Research on New Traditional Chinese Medicines". (1) Skin irritation test: Approximately 24 hours before the test, the hair on both sides of the spine on the back of the animal was removed, without damaging the skin. The hair removal area was approximately 3cm × 3cm on both the left and right sides. Approximately 0.5g of the test substance was applied directly to one side of the skin, covering an area of ​​2.5cm × 2.5cm. The control side was treated with solvent (no treatment was performed if no solvent was used). The treatment was repeated once a day for 14 consecutive days. Starting from the second day, the hair was clipped before each application, and any residual test substance was removed with water or a non-irritating solvent. The results were observed after 1 hour, and scoring was performed according to the "Cosmetic Safety Technical Specifications" (2015 edition). The control and test areas were treated in the same way. After the experiment, the average score for each animal was calculated daily, and the skin irritation intensity was determined based on the average score. (Table 2)

[0025] Table 2 Results of skin irritation (2) Skin allergy test: About 24 hours before administering the test substance, the hair on the left side of the guinea pig's back was removed, with a hair removal area of ​​4-6 cm. 2 .

[0026] Induction Contact: Approximately 0.2 g of the test substance was applied to the shaved area on the left side of the experimental animal. The negative control group was treated with a solvent (no treatment was performed if no solvent was used). The area was covered with two layers of gauze and one layer of cellophane, and then sealed with non-irritating adhesive tape for 6 hours. The positive control group was treated with an induction concentration of 2,4-dinitrochlorobenzene solution in the same way. The same method was repeated on days 7 and 14. Challenge Contact: 14 days after the last induction, approximately 0.2 g of the test substance was applied to a 2cm × 2cm shaved area on the right side of the guinea pig's back (hair was removed 24 hours before contact). The area was then covered with two layers of gauze and one layer of cellophane, and then fixed with non-irritating adhesive tape for 6 hours. The negative and positive control groups were treated with the test substance as is and with a challenge concentration of 2,4-dinitrochlorobenzene solution in the same way, respectively. Skin reactions were observed 24 hours and 48 hours after stimulation and scored according to the scoring criteria for skin allergy test in the "Cosmetic Safety Technical Specifications" (2015 edition). The scores, recovery status and time of each group at different times were recorded.

[0027] Table 3 Results of Skin Allergies 3. High-performance liquid chromatography (HPLC) detection This experiment, based on Chapter 4.1 of the "Cosmetic Safety Technical Specifications" (2015 edition), specifically regarding 23 components including methylisothiazolinone, used high-performance liquid chromatography (HPLC) to determine the final content of preservatives (methyl 4-hydroxybenzoate) in Compound Purple Gromwell Lip Ointment. The method was as follows: 1.0 g of sample (accurate to 0.001 g) was weighed into a stoppered colorimetric tube, 8 mL of methanol was added, the mixture was vortexed for 30 s, ultrasonically extracted for 20 min, and the volume was adjusted to 10 mL with methanol. After shaking, the mixture was centrifuged, and the supernatant was filtered through a 0.22 μm microporous membrane. The filtrate was used as the test solution.

[0028] The chromatographic column is: C 18 Column, 250×4.6mm, 5μm.

[0029] Flow rate: 1.0 mL / min, injection volume: 10 μL, column temperature: 30℃.

[0030] The diode array has a wavelength of 254nm.

[0031] Mobile phase: 0.12% phosphoric acid aqueous solution + acetonitrile gradient mobile phase, with the following ratios: 0 min: 90 V: 10 V, 5.00 min: 90 V: 10 V, 29.00 min: 50 V: 50 V, 41.00 min: 65 V: 35 V, 52.00 min: 35 V: 65 V, 57.00 min: 5 V: 95 V, 62.00 min: 90 V: 10 V, 67.00 min: 90 V: 10 V.

[0032] The test results are shown in Table 4.

[0033] Table 4. Preservative test report of the compound comfrey lip balm prepared in this embodiment. As shown in Table 4, the content of methyl 4-hydroxybenzoate in the compound comfrey lip balm prepared in this embodiment was determined to be 0.00286% (w / v, i.e., mg / mL), which complies with Chapter 4.1 of the "Cosmetic Safety Technical Specifications" (2015 edition).

[0034] 4. Antibacterial test In this experiment, thermotolerant coliforms, Staphylococcus aureus, Pseudomonas aeruginosa, molds, and yeasts were selected as bacterial strains to evaluate the antibacterial activity of different concentrations of compound comfrey lip balm. The bacterial concentration was 4 × 10⁻⁶. 6 Different masses of compound comfrey cheilitis ointment were added to the bacterial suspension at CFU / mL, with the mass ratio of compound comfrey cheilitis ointment to bacterial suspension being 1:10, 1:100, and 1:1000, respectively. Nutrient agar medium was poured into sterile petri dishes to prepare plates. After cooling, 100 μL of the above bacterial suspension was taken from each plate and evenly spread on the plate. The plates were then placed in an incubator for co-cultivation for 24 hours. The growth of bacteria in the culture medium was observed, and the antibacterial effect was judged by the number of colonies.

[0035] Table 5. Microbial community report of the compound comfrey lip balm prepared in this embodiment. As shown in Table 4, the bacterial flora in the compound comfrey lip balm prepared in this embodiment met the requirements of Chapter 5, Section 2 of the "Cosmetic Safety Technical Specifications" (2015 edition).

[0036] The compound comfrey lip balm prepared in this invention can be used to improve chronic cheilitis. Chronic cheilitis mainly refers to long-term inflammatory changes in the skin of the lips. Clinically, patients with chronic cheilitis often present with dry, peeling, and cracked lips, and may even experience pain and itching. According to the clinical syndrome characteristics of cheilitis in traditional medicine, cheilitis is quite similar to "lip wind disease" in traditional Chinese medicine, which is a disease characterized by redness, swelling, itching, pain, cracking, oozing, dryness, and peeling of the lips. Its syndrome falls under the categories of "lip wind" and "lip swelling," and the syndrome pattern is a mixture of deficiency and excess: excess is due to wind, fire, dampness, and heat, with severe redness, swelling, itching, ulceration, and pain of the lips; deficiency is due to yin deficiency and blood dryness, with redness, dryness, cracking, oozing, and crusting of the lips.

[0037] In this formula, Lithospermum erythrorhizon is used as the principal ingredient. It has the functions of cooling the blood and detoxifying, directly targeting the root cause of inflammation, and can clear heat and detoxify, moisten dryness and promote tissue regeneration. In traditional Chinese medicine, the core pathogenesis of inflammation is often "internal accumulation of heat toxins" (such as redness, swelling, heat and pain) or "blood heat stagnation" (such as prolonged inflammation and local tissue damage). Lithospermum erythrorhizon is cold in nature and can directly clear heat toxins from the blood, relieving "heat" (redness, swelling, heat and pain) from the root cause; its "blood-activating" effect can dredge local stagnant qi and blood, improve blood circulation disorders caused by inflammation, and promote the discharge of pathological products (such as pus and inflammatory exudates); its "swelling reduction and tissue regeneration" can repair inflammatory damaged tissues and accelerate healing, which is the core force in improving inflammation.

[0038] Angelica sinensis, as an assistant herb, assists in promoting blood circulation and unblocking collaterals, enhancing the efficacy of the principal herb. In this formula, while Lithospermum erythrorhizon can cool and promote blood circulation, its cold nature can easily cause blood stagnation. Angelica sinensis, being pungent and warm, can promote blood circulation, enhancing the blood-activating and collateral-unblocking power of Lithospermum erythrorhizon, preventing excessive cooling of the blood from causing local blood stagnation. Simultaneously, its blood-activating and pain-relieving effects can directly alleviate pain caused by inflammation, complementing the blood-cooling and swelling-reducing effects of Lithospermum erythrorhizon, preventing excessive coldness from damaging the local yang qi of the cheilitis. This provides a material basis for inflammation healing while avoiding recurrence of inflammation due to "treating the pathogenic factors and harming the body's resistance."

[0039] Traditional Chinese medicine believes that "wind evil is prone to movement and change," and cheilitis, as a skin inflammation, is easily aggravated by external wind invasion. Therefore, this formula uses five herbs as adjuvants: Saposhnikovia divaricata, Rehmannia glutinosa, Angelica dahurica, Boswellia carterii, and Commiphora myrrha. Among them, Saposhnikovia divaricata, with its pungent and dispersing properties, can "dispel wind," clearing away wind evil attached to the affected area and preventing the spread of inflammation or itching and discomfort caused by wind evil; its "dampness-clearing" effect can also alleviate the "dampness evil" accompanying inflammation (such as purulent exudation and increased local secretions induced by cheilitis), assisting the principal and assistant herbs in clearing pathological products. Rehmannia glutinosa, being cold in nature, can assist Lithospermum erythrorhizon in strengthening the "blood-cooling" power, further clearing heat toxins from the blood in cases of "severe heat toxin" in inflammation (such as obvious redness and swelling, and strong burning sensation). Angelica dahurica can reduce swelling and drain pus. When cheilitis develops into a suppurative inflammation, Angelica dahurica can promote the drainage of pus and prevent pus accumulation from aggravating the inflammation. At the same time, its pungent and warm properties can enhance the wind-dispelling power of Saposhnikovia divaricata, and its analgesic effect directly relieves inflammatory pain, especially for local swelling and stinging pain. Frankincense and myrrh are used together to enhance the effects of promoting blood circulation and relieving pain. Both are warm in nature and can balance the cold nature of Lithospermum erythrorhizon and Rehmannia glutinosa, preventing the overall formula from being too cold and causing slow local tissue repair.

[0040] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention in any way. Any simple modifications, alterations, and equivalent changes made to the above embodiments based on the inventive essence shall still fall within the protection scope of the present invention.

Claims

1. A compound comfrey lip balm for improving chronic cheilitis, characterized in that, It is made by adding methylparaben to the following ingredients in the following proportions: 6g of Lithospermum erythrorhizon, 1g of Angelica sinensis, 1g of Saposhnikovia divaricata, 1g of Rehmannia glutinosa, 1g of Glycyrrhiza uralensis, 1g of Angelica dahurica, 1g of Boswellia carterii, 1g of Commiphora myrrha, 0.01g of methylparaben, 0.1g of Vitamin E, 30g of beeswax, and 150mL of olive oil.

2. The compound comfrey lip balm for improving chronic cheilitis according to claim 1, characterized in that, The amount of methylparaben added is ≤0.1%mg / mL.

3. A method for preparing a compound comfrey lip balm for improving chronic cheilitis as described in claim 1 or 2, characterized in that, The method is as follows: S1. After mixing Angelica sinensis, Saposhnikovia divaricata, Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica dahurica, Boswellia carterii and Commiphora myrrha, a mixture is obtained; S2. After heating the olive oil at 110°C, add it to the mixture obtained in S1, fry it, filter the residue, and obtain medicinal oil A. S3. Add Lithospermum erythrorhizon to the medicinal oil A obtained in S2, heat it at a temperature of 160℃, filter the residue, and obtain medicinal oil B. S4. Cool the medicinal oil B obtained in S3 naturally to 60°C, then add vitamin E and methylparaben, stir to dissolve, and obtain medicinal oil C; S5. After heating and melting the beeswax, add it to the medicinal oil C obtained in S4 and mix it evenly at a temperature of 70°C. Add methylparaben, mix evenly, pour it into the lipstick tube, and cool it at room temperature until the balm solidifies to obtain the compound comfrey lip balm for improving chronic cheilitis.

4. The method according to claim 3, characterized in that, The heating time in S2 is 20 minutes.

5. The method according to claim 3, characterized in that, The frying time in S2 is 30 minutes.

6. The method according to claim 3, characterized in that, The heating time in S3 is 20 minutes.

7. The application of a compound comfrey lip balm for improving chronic cheilitis as described in claim 1 or 2, characterized in that, The compound comfrey lip balm is used to improve chronic cheilitis.

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