3427 results about "Disease" patented technology

The present application provides a method for diagnosing and / or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises determining and / or evaluating circulatory parameters, retinal function, retina morphology and / or visual relating quality of life (QOL).

Frog farming method and frog cage are provided. The method comprises: I, putting young frogs in the frog cage in spring; II, putting lure attracting mosquitoes into the frog cage into the frog cage in summer and autumn, thereafter the frogs feed on the mosquitoes; III, avoiding snakes entering the frog cage in the place where the snakes inhabit; IV, covering the frog cage with plastic film in winter, mounting an electric lamp in the frog cage, increasing the temperature of air in the frog cage to keep the frogs not hibernating and promote the frogs to grow; V, adding artificial lure if necessary. The frog cage includes a fixed frog cage and a vehicle-mounted frog cage, both including inner tiers, wherein a water basin, a terrace and a stairway communicating the upper and lower tiers are arranged on each tier, and the frog cage is covered with a mesh enclosure. The frog framing method and frog cage have the advantages that the frogs are farmed in multi-tier cages, lures are used outdoors to attract insects, pests are eliminated for crops, natural ecology is balanced, and food sources are also provided for human; cage framing of frogs is very low in cost; frogs farmed have high reproductive rate, high disease resistance and high feed conversion capacity.

The invention relates to a traditional Chinese medicine composition with functions of tonifying qi and nourishing blood for livestock. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of astragalus membranaceus, 10-40 parts of spina gleditsiae, 10-20 parts of angelica sinensis, 10-20 parts of codonopsis pilosula, 10-30 parts of uniflower swisscentaury root, 10-30 parts of ligusticum wallichii, 10-20 parts of cowherb seed, 10-20 parts of fruit of liquidambar formosana hance and 1-10 parts of iron sucrose. The traditional Chinese medicine composition is scientific and reasonable in component, free of toxic and side effects and medicine residue, convenient to take and low in cost, has the functions of tonifying qi and nourishing blood, stimulating the menstrual flow and prompting lactation, and is capable of effectively treating diseases of postpartum hypogalactia, breast milk stoppage and the like which are normal in livestock.

This invention belongs to the field of biomedicine and relates to a biomarker for the early diagnosis of Alzheimer's disease and its application. Specifically, it discloses a biomarker for the early diagnosis of Alzheimer's disease, namely the Maf1 gene or its protein. High expression of the Maf1 gene or its protein in neuronal cells indicates that the test subject is in a high-risk group for Alzheimer's disease. This invention provides a new diagnostic and therapeutic target for AD.

The present application relates to the field of microbiological technology, and particularly relates to a pathogenic bacterium causing root rot symptoms of red heart disease of Astragalus membranaceus and application thereof, the pathogenic bacterium is Fusarium sp. Fusarium sp. FUS-001-2025, preserved in China General Microbiological Culture Collection Center on March 16, 2026, with the preservation number of CGMCC No. 42529; it is determined to be a new recorded strain of Fusarium sp. through morphological and molecular identification, and the bactericide sensitivity determination shows that 25% silthiofam·prochloraz has the strongest inhibition effect, 25% bromothalonil, 50% azoxystrobin and 70% methylthiophanate have significant inhibition at high concentrations. The present application provides an important pathogenic bacterium resource for the pathogenic mechanism, disease resistance evaluation and development of control agents of red heart disease of Astragalus membranaceus.

A compound of formula (I) or a pharmaceutically acceptable salt thereof is provided, which is useful as a pharmaceutical ingredient having S1P3 receptor antagonistic activity in the prevention and / or treatment an S1P3-mediated disease, wherein all symbols represent the same meaning as the symbols described in the specification. A drug is also provided, which containing, as an active ingredient, a compound having S1P3 receptor antagonistic activity in the prevention and / or treatment an S1P3-mediated disease.

Aspects of the disclosure relate to compositions and methods useful for treating Huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.

The present invention relates to circular RNA molecules, methods of producing circular RNA molecules, circular and non-circular intermediates thereof, and methods of treating or preventing a disease. In particular, the present invention provides circRNAs that can be prepared via chemical circularization of RNA, regardless of the circRNA sequence, length or size. Due to chemical nature of the circularization process, it allows the attachment of tags, markers, etc. after the circularization at a position in close proximity to the position where the circRNA was circularized.

The application discloses application of a rice disease resistance related gene Os04g55720 in bacterial blight breeding and relates to the technical field of modern biotechnology and genetic engineering technology.The rice disease resistance related gene Os04g55720 has a nucleotide sequence as shown in SEQ ID NO.1, is composed of 2821 nucleotides, has a coding region sequence as shown in SEQ ID NO.2, and has a sequence of 2148 nucleotides; the gene encodes a protein with 613 amino acids, and has an amino acid sequence as shown in SEQ ID NO.3.The application proves that overexpression of Os04g55720 enhances the resistance of rice to bacterial blight by means of molecular biology and biochemical technology, and shows that the rice protein OsPGDH-3 can effectively control the incidence of rice bacterial blight at a relatively low level.The application provides a new idea, strategy and gene resource for green prevention and control of rice bacterial blight.

Provided herein, in part, is a method of treating or preventing obesity or an obesity-related disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a small molecule inhibitor of an Activin receptor Type II.

The application provides a CPA primer probe set, a kit, a detection method and application for rapidly detecting Candidatus Liberibacter aurantii in the field, and belongs to the technical field of molecular detection.The application provides a CPA primer probe set for detecting Candidatus Liberibacter aurantii, which comprises a primer set and a probe HLB-P; the primer set comprises HLB-FB, HLB-AP, HLB-OP, HLB-IP, HLB-CPR and HLB-RB, and the nucleotide sequences thereof are shown in SEQ ID NO:1 to SEQ ID NO:6 in sequence; and the nucleotide sequence of the probe HLB-P is shown in SEQ ID NO:7. The application further provides a kit, a device and a detection method for detecting Candidatus Liberibacter aurantii. The application provides a reliable technical means for diagnosing different tissues of Candidatus Liberibacter aurantii, and lays an important technical foundation for real-time monitoring of field diseases and development of prevention and control strategies.

Provided herein are isotopologues of MC4R agonist, processes for the preparation of the compounds, pharmaceutical compositions comprising the compounds, and methods of treating, managing, or preventing certain conditions, diseases, or disorders using the compounds or pharmaceutical compositions described herein.

Aspects of the application provide anti-IL-13 antibodies and methods of using the same in treating IL-13-mediated diseases (e.g., allergic disease or other inflammatory diseases).

The present disclosure relates to a lipid conjugated bivalent peptide ligand which bind to Protein Interacting with C Kinase – 1 (PICK1) and thereby inhibit PICK1. The PICK1 inhibitors of the present disclosure comprise a peptide portion comprising two peptide ligands of PICK1, and a non-peptide portion comprising a linker, linking the two peptide ligands, and a lipid. The disclosure furthermore relates to therapeutic and diagnostic use of said PICK1 inhibitor for treatment of diseases or disorders associated with maladaptive plasticity.

The present disclosure provides immune cells comprising an exogenous T cell receptor (TCR) and T cell modulatory polypeptides (TMPs) for use in methods of treating a disease or condition. The TMPs comprise one or more immunomodulatory polypeptides that stimulate activation and / or proliferation of the immune cell. Also disclosed are methods of expanding a population of immune cells and methods of selectively delivering an immunomodulatory polypeptide using the same. Also disclosed are pharmaceutical combinations comprising the same and their use in methods of treating a disease or condition.

The present application relates to the field of medicinal chemistry and pharmacotherapy, and in particular to a class of bazedoxifene and its preparation method and application. The bazedoxifene derivative is used for gp130 small molecule inhibitor, the compound is a compound shown in formula (I), or a pharmaceutically acceptable salt or ester thereof, and relates to the application of tumor-related activity and the like, in particular the application in preparing drugs for preventing and / or treating diseases related to tumors, especially colorectal cancer.

A device may receive physical activity data for a subject, wherein the physical activity data comprises raw acceleration data. A device may derive a plurality of metrics from the raw acceleration data, wherein the plurality of metrics comprise a plurality of pattern-related metrics. A device may input the plurality of metrics into a deployed machine learning model. A device may be configured to perform receiving, from the deployed machine learning model, a physical activity score. A device may calculate a risk score for at least one disease or condition based on the physical activity score.

The present disclosure relates to solid state forms of Compound (1) freebase. The present disclosure also relates to processes for the preparation of the solid state forms, the pharmaceutical compositions comprising the forms, and the use thereof, e.g., in the treatment and prevention of disorders in which NLRP3 activity is implicated.

The present disclosure is directed to antibody drug conjugates (ADCs) comprising an antibody or antigen binding fragment thereof that binds IL-1RAP. The ADCs of the present disclosure are useful for, among other things, treating diseases with upregulated IL-1RAP expression.

The present invention relates to a compound of formula (I), or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof, a pharmaceutical composition thereof, and a use thereof in the treatment and / or prevention of diseases modulated by wild-type and / or mutant Bcr-Ab11 kinase.

The present disclosure provides a method of reducing, preventing or treating an intestinal infection, preventing or treating a disease associated with protozoan parasite of the genus Eimeria, inhibiting an oocyst sporulation of a protozoan parasite or preventing a sporozoite invasion or reproduction, preventing or treating coccidiosis, promoting growth performance, controlling, treating and / or preventing necrotic enteritis in a subject, comprising administering to the subject an effective amount of a composition comprising a Crassocephalum rabens (CR), a bioactive extract thereof (CRE), an active ingredient(s) contained in a CR (CR_API) or CRE (CRE_API), a combination of two or more of a CR, a CRE, a CR_API and a CRE_API, or one or more of a-linolenic acid, citric acid, lactic acid, mannitol, palmitic acid, aspartic acid and 1-monomyristin.

The application discloses application of a drug composition of bacosol and donepezil in preparation of a drug for treating Alzheimer's disease. The application first discovers that bacosol has double-target point inhibitory activity on BACE1 and AChE. Through cell and animal model verification, the bacosol single drug and the composition can exert an anti-AD effect through a multi-target point mechanism, and the composition with a molar ratio of 1:1 to 1:10 has a significant synergistic effect, wherein the synergistic effect is the most significant when the molar ratio is 1:1. The application provides a new treatment method for Alzheimer's disease.

The invention relates to a respiration-based disease detection system for animals, which measures, by means of electronic pressure sensors, the vacuum effect generated by animals during respiration, evaluates said measurements, analyzes the magnitude and frequency of the force applied to the diaphragm, assesses the muscular strength of the diaphragm, and provides an output based on said assessment.

The application relates to a fusion protein and application thereof in the field of biotechnology. A polypeptide fragment for specifically recognizing a single-molecule phospholipid membrane and a polypeptide fragment for specifically recognizing a tissue or a cell are connected to form a fusion protein which can be specifically combined to a fat body surface in a non-covalent manner, so that precise targeting of the fat body is realized. The fat body targeting peptide segment can be widely used in the fields of precise drug delivery and vaccine preparation, so as to be used for treating diseases such as cancer, infectious diseases and metabolic diseases. Lung tissues and breast cancer cells are taken as target points, and good targeting of the fat body is realized.

This invention relates to the interdisciplinary field of medical image analysis and artificial intelligence, and particularly to a method, device, and medium for detecting non-occlusal abnormalities based on oral images. The method first acquires oral images and determines their abnormality category: a first abnormality (dependent on the characteristics of a single tooth) or a second abnormality (dependent on the spatial relationships between multiple teeth). Based on the category determination, an adaptive differential detection process is executed: if it is a first abnormality, a two-stage process of tooth position detection and single-tooth recognition is used to output a detection result associated with a precise FDI number; if it is a second abnormality, an end-to-end target detection model directly outputs the abnormality type and location region; if it is a mixed category, the two processes are executed in parallel and the results are intelligently integrated. This invention achieves automated, precise, and structured detection of non-occlusal diseases.

This invention discloses an anti-HIV antibody or a functional fragment thereof and its applications. The anti-HIV antibody or functional fragment disclosed in this invention includes a heavy chain complementarity-determining region and a light chain complementarity-determining region. This antibody or functional fragment has good specificity and sensitivity for HIV and can be used to detect human immunodeficiency virus (HIV) and for the diagnosis or auxiliary diagnosis of related diseases using HIV as a biomarker.

The present application relates to a crystal form of a compound of formula (I) and a preparation method and application thereof. Specifically, the present application provides a crystal form of a compound of formula (I), which has good stability, good drug efficacy, and good safety, and can be used for preparing a drug for treating or preventing feline transmissible enteric disease virus infection or coronavirus infection caused diseases.