388 results about "Hydrobromide" patented technology

The invention relates to a surface precipitation-free flame-retardant polypropylene compound and a preparation method thereof. The surface precipitation-free flame-retardant polypropylene compound comprises the following components by weight percent: 70-98.5% of polypropylene resin, 1-15% of melamine hydrobromide, 0.3-7% of phosphinates, 0.2-4% of flame retardant synergist, 0-2% of synergetic flame retardant, 0-1% of antioxidant and 0-1% of processing acid. The preparation method thereof is implemented as follows: weighting the above components based on proportion, evenly mixing, melt-mixing the above mixture, pelletizing and drying to obtain the product in the invention. The surface precipitation-free flame-retardant polypropylene compound has high flame retardant efficiency, good flowability, no precipitation, and high flame retardant rating up to UL94 V-0, and can satisfy the use requirements of flame retardant materials in building materials, electrical appliance casings, sockets, bellows, lighting lamps and the like.

The invention discloses a transparent cold-resistant flame-retardant polypropylene material and a preparation method thereof. The material comprises the following components in parts by weight: 65-85 parts of polypropylene resin, 0.1-0.3 part of white oil, 5-20 parts of ethylene-octene copolymer, 3-10 parts of linear low-density polyethylene, 1-5 parts of phosphorus-nitrogen-bromine composite flame retardant, 0.1-0.4 part of flame-retardant synergist, 0.1-0.4 part of nucleating agent, 0.2-0.5 part of antioxidant and 0.2-0.5 part of lubricant. The phosphorus-nitrogen-bromine composite flame retardant comprises the following components in parts by weight: 60-90 parts of organic or inorganic hypophosphite, 10-30 parts of phosphoric-acid-containing piperazidine hydrobromide and 0.5-5 parts of silane coupling agent. The polypropylene material disclosed by the invention has high transparency and high cold resistance as well as flame retardancy. The material has the advantages of favorable compatibility and precipitation resistance, and can be used for preparing plastic products requiring high transparency, high cold resistance and flame retardancy.

The present invention provides a novel polymorphic form of olopatadine hydrochloride ([(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride), a selective histamine H1-receptor antagonist that is used for the treatment of ocular symptoms of seasonal allergic conjunctivitis. The present invention also provides novel methods for producing olopatadine on a large scale, and in a manner that is cost effective, provides a low level of impurities and eliminates the need to use the costly and dangerous base, butyllithium, which is used in prior art reactions for making olopatadine. The present invention further provides novel processes for carrying out a large scale production of 3-dimethylaminopropyltriphenylphosphonium bromide and its corresponding hydrobromide salt, which are employed in the production of olopatadine, and pharmaceutically acceptable salts of olopatadine.

Methods of treating high serum levels of total cholesterol, low density lipoprotein and triglycerides in a mammal by administering therapeutically effective doses of N-(4-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)acetamide or a salt thereof such as a hydrochloride or hydrobromide salt.

The invention relates to 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole shown as a chemical structural formula I and a salt thereof. The chemical structural formula I is shown in the specifications, wherein R is selected from H, alkyl with 1-2 carbon atoms, or straight chain alkyl or branch chain alkyl with 3-4 carbon atoms; and X1, X2, X3, X4 and X5 is selected from hydrogen, alkyl with 1-2 carbon atoms, hydroxyl, methoxyl, oxethyl, trifluoromethyl, fluorine, chlorine, bromine, nitro or amino. A preparation method of the 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole comprises the following steps of: feeding 2-(1,2,4-triazol-1-yl)-2-bromoalkylketone and aryl thiourea in the molar ratio of 1:1, and carrying out a reflux reaction in ethanol; and after reacting, distilling under reduced pressure to remove a solvent, adding ethyl acetate for washing, filtering, drying to obtain 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole hydrobromide, neutralizing the hydrobromide with ammonia water, extracting with ethyl acetate, drying, and distilling under reduced pressure to obtain 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole. The 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole has high antitumor activity, and can be applied to preparation of an anticancer medicament.

Provided are crystalline forms of clopidogrel hydrobromide and processes for their preparation.

The invention discloses an efficient precipitation resistant flame retardant composition and a preparation method thereof, in particular to the highly efficient precipitation resistant flame retardant composition suitable for flame retardant polyolefin materials and the preparation method thereof. The highly efficient precipitation resistant flame retardant composition comprises the following components by weight percent: 5-90% of melamine hydrobromide, 5-75% of phosphinate, 5-15% of flame retardant synergistic agent and 0-5% of flame retardant synergist. The preparation method of the efficient precipitation resistant flame retardant composition is as follows: the powder or liquid of the phosphinate, the melamine hydrobromide, the flame retardant synergistic agent and the flame retardant synergist are fully and evenly mixed to obtain the highly efficient precipitation resistant flame retardant composition. The efficient precipitation resistant flame retardant composition of the invention can be used for polyethylene, polypropylene, polystyrene and various polyolefin copolymers, and is especially suitable for polypropylene, and the flame retarding grade can be up to UL94 V-0; and the efficient precipitation resistant flame retardant composition has high flame retarding efficiency, good fluidity and no precipitation, can meet the use requirements of flame retardant materials for use in building materials, electric appliance shells, sockets, bellows, lighting lamps and the like.

The invention discloses 4-alkyl-2-arylamino-5-(1,2,4-triazole-1-group) thiazole and salts thereof shown in a formula I, wherein R is selected from H, alkyl groups of C1-C2 and straight-chain alkyl groups or branched-chain alkyl groups of C3-C4; X1, X2, X3, X4 and X5 are selected from hydrogen, alkyl groups of C1-C2, hydroxide group, methoxy group, oxyethyl group, trifluoromethyl, fluorine, chlorine, bromine, nitryl, amino group, acetyl amino group, methanesulfamide, ethoxycarbonyl or carboxyl; and the salts of the 4-alkyl-2-arylamino-5-(1,2,4-triazole-1-group) thiazole are selected from hydrochloride, hydrobromide, nitrate, sulfate, phosphate, mesylate, p-toluene sulfonate, tartrate, lactate or malate. The 4-alkyl-2-arylamino-5-(1,2,4-triazole-1-group) thiazole is applied to preparation of medicaments for resisting cervical cancer or lung neoplasms.

The invention provides a chiral pyrrolidine functionalized imidazolium salt, and a preparation method and an application thereof. The chiral pyrrolidine functionalized imidazolium salt is bromized 1-[2-(S)-(pyrrolidyl)methyl]-3-benzoyl methyl imidazole hydrobromide. The preparation method of the chiral pyrrolidine functionalized imidazolium salt comprises the following steps of: by taking natural amino acid L-proline as the starting raw material, obtaining the chiral pyrrolidine functionalized imidazolium salt through a plurality of conventional organic synthetic reactions such as Boc acylation, carboxylic acid reduction, hydroxyl sulfonylation, nucleophilic substitution of imidazole anions, quaternization of halohydrocarbon and de-Boc protection. The chiral pyrrolidine functionalized imidazolium salt provided by the invention is capable of catalyzing asymmetric Michael addition reaction of cyclohexanone and nitroolefin, and has extremely high diastereoselectivity and enantioselectivity.

The invention relates to a Prasugrel hydrobromide tablet suitable for preparation by a direct compression process. In addition to containing the active component Prasugrel hydrobromide, the tablet also contains a filling agent, a disintegrating agent and a lubricant. And the tablet has the advantages of high dissolution rate, good stability, high safety, and simple preparation process.

The method relates to a method for purifying ceftazidime, more concretely relating to a method for preparing high quality ceftazidime pentahydrate by impure, high-polymer impurity content ceftazidime through crystallization. It prepares impure, high-polymer impurity content ceftazidime pentahydrate, ceftazidime Hclú¼ceftazidime hydrobromide or ceftazidime overdue or recovered from the market, into a ceftazidime water solution, then regulates the pH value of the ceftazidime water solution to 1.5-2.5 by alkali or acid, here the impurity ceftazidime polymer is separated out with a little ceftazidime, and the separated-out matter is filtered, and the pH value of the filtrate is regulated to 3.5-4.8 by alkali so that the ceftazidime pentahydrate crystals are separated out. The method is simple and convenient to operate, low-cost, good-safety and high-yield. The obtained ceftazidime pentahydrate crystals are high purity and the polymer is low-content, reaching pharmacopoeia specified requirements.

The invention discloses low-halogen polypropylene flame-resistant materials and a preparing method thereof. The low-halogen polypropylene flame-resistant materials are obtained by the fact that homo-polypropylene, composite-prepared fire retardant, lubricating agents, antioxygen agents and inorganic filler are evenly mixed, and then extrusion pelleting is carried out through a double-screw extruder. The composite-prepared fire retardant is formed by mixing of phosphorus-containing fire retardant phenyl aluminum hypophosphite, bromine-containing fire retardant melamine hydrobromide or flame retardant TBC and flame retardant synergist 2,3-dimethyl-2,3-diphenylbutane. The antioxygen agents are formed by mixing of hindered phenol antioxygen agents 1010 and phosphite ester antioxygen agents 168. The phenyl aluminum hypophosphite is used as a foundation and is mixed with brominated flame retardant in a composite mode, through P-Br synergistic effect, flame retardant with the total adding amount not larger than 2wt% is used, flame-resistant PP with balanced comprehensive performance is obtained, the requirement for environment protecting is met, the flame resistance reaches American UL941.6mm V2, and the mechanical property and the electrical property are great.

The invention relates to imidazolium bromide ionic liquid containing amine groups and a preparation method and application of the ionic liquid. The structural formula of the imidazolium bromide ionic liquid containing amine groups is shown as the formula (I). Under protection of nitrogen, 3-bromopropylamine hydrobromide or 2-bromoethylamine hydrobromide and imidazole are dissolved in anhydrous ethanol after being mixed, reflux reaction is conducted for 20-25 h at 85-95 DEG C, ethanol is removed through vacuum distillation, an organic solvent is added, stirring and filtering are conducted, the organic solvent is removed from filter liquid through vacuum distillation, a KOH aqueous solution is added after vacuum drying so that the pH of the solution can be 8-9, filtering is conducted, solid is added into anhydrous ethanol and stirred, filtering is conducted again, filter liquid is dried in a vacuum mode, and the target product is obtained. In the process that catalytic epoxidation compound is used for synthesizing cyclic carbonate, the ionic liquid has the advantages that the yield is high, activity is high, no catalysts or solvents are needed, reaction conditions are mild, stability is high, and recycling is conducted many times. Please see the formula (I) in the description.

The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

The invention relates to a derivative of an aza-aryl compound as shown in the formula I, and the derivative is capable of adjusting erythropoietin (EPO). The derivative comprises the sodium salt, meglumine salt, hydrobromic acid and hydrochloride of the aza-aryl compound as shown in the formula I, and is high in solubility and water stability in an aqueous medium. In addition, the inventor discovers that the derivative is effective for treating cancers and related anemia.

Preparation of sinomontanine A and its hydrobromic acid salt are disclosed. The procedure is carried out by crushing block root of Gaowutou, extracting by alcohol reflux or acid water leakage or alcohol immersion, concentrating to thin paste to obtain crude extract, acidifying crude extract to pH=1-5, obtain acidified liquid, adsorbing the acidified liquid by exchange resin cation or macroporous adsorbing resin or alumina, washing by water, washing by chloroform or/and alcohol, collecting eluent, concentrating extractive, dissolving the extractive into alcohol, laying aside for 1 day, crystallizing and washing by alcohol to obtain final product. It has higher purity.

The invention relates to the medical technical field, in particular to a new triazole alcohols antifungal compound and salts thereof with the following chemical structure formula and a preparation method and the application thereof; R1 is selected from n-propyl, isopropyl or butyl; R2 is selected from alkyl or halogen; the salts include hydrochloride, hydrobromide and methane sulphonate. The compound has strong antifungal activity on various fungi in shallow parts and deep parts. Compared with the antifungal medicines used in the existing clinical applications, the compound has the advantages of high efficiency, low toxicity, broad antifungal spectrum, and the like, and can be used for preparing new antifungal medicines.

Ethamine compound is obtained by condensing starting materials of 6-bromoisovanillin and tyramine under catalysis of NaBH4 in carbinol. In formylation of ethamine compound, aminic acid and formaldehyde of same amount are used to produce formyl compound, with temperature between 90 DEG C. and 110 DEG C., 8h. Racemic bromonarwedine is obtain by oxidation and cyclization of the formyl compound. Racemic narwedine is obtained by reduction reaction under catalysis of NaCO2H, PPh3, Pd(OAc)2. Racemic narwedine is transformed into (-)-narwedine by a process of crystal inoculation. (-)-narwedine is reduced into unsaturated ketone by (-)-N-methyl ephedrine as chiral reagent, whereby optically active alcohol is obtained, and (-)-galanthamine is also obtained.

The invention relates to the field of chemosynthesis, a trihydrate 3-aminopropyl amine ethyl thiophosphoric acid(amifostine)stable crystal and a preparation method thereof. The method comprises the following steps: step one, according to the molar ratio of between 1.01 to 1.0 and 1.2 to 1.0, N-(2-bromethyl)-1,3-propane diamine bi-hydrobromide and sodium thiophosphate are dissolved in water, are added with a polar aprotic solvent as an accelerant and react at a temperature of between 10 and 40 DEG C; after reaction, the mixture is directly cooled to precipitate a coarse product of trihydrate amifostine; step two, the coarse product of the trihydrate amifostine obtained in the step one is subjected to primary recrystallization and purification, is dissolved in the water and is precipitated out through methanol to obtain anhydrous amifostine; and step three, the anhydrous amifostine obtained in the step two is subjected to secondary recrystallization and purification, is dissolved in the water and is decolored through active carbon; and the trihydrate amifostine crystal is precipitated out through ethanol. The purity of the crystal is more than or equal to 99.5 percent; the content of mercaptan is less than or equal to 0.1 percent; the content of other relevant substances is less than or equal to 0.1 percent; and a product is stable and is suitable for scale production.

The invention discloses a phosphorus, nitrogen and bromine compound system fire retardant which comprises the following raw materials in parts by weight: 50-65 parts of melamine hydrobromide, 50-65 parts of ammonium polyphosphate and 4.5-6 parts of fire retarding synergism synergist. The fire retardant integrates the advantages of a phosphorus based fire retardant and a bromine based fire retardant, so that properties of the phosphorus based fire retardant and the bromine based fire retardant are complemented. In addition, antimony trioxide is replaced by the fire retarding synergism synergist, so that consumption of the fire retardant is reduced, and the fire retarding property, the processablility and the physical and mechanical properties of a material are improved. The fire retardant can be directly added and filled in to be processed into a product, so that a processing technique is simple; the production cost is lowered; furthermore, the compound fire retardant is added to the material to ensure that the bromine content of the material is low (approximately a halogen-free requirement is met in a modified product); and modern high-efficiency and environment-friendly requirements are met.

The invention discloses a new antharcycline anticancer medicine derivative 9-hydroxymethyl-10-imidazolanthracenehydrazone, and a synthetic method and an application thereof. The synthetic method of 9-hydroxymethyl-10-imidazolanthracenehydrazone comprises the following steps: weighing 9,10-anthracenedicarboxaldehyde and 4,5-dihydroimidazol-2-ylhydrazine hydrobromide having a same molar amount with 9,10-anthracenedicarboxaldehyde, mixing them, dissolving them in an organic solvent, and carrying out an aldehyde-amine condensation reaction to obtain mixed products; carrying out silica gel column chromatography of the mixed products, eluting with a mixed solvent comprising methanol and one of dichloromethane, chloroform and ethyl acetate, concentrating the obtained eluate, and drying to obtain a target intermediate; and carrying out a reducing reaction of the target intermediate and sodium borohydride in the presence of an alcoholic solvent, adding water to the reaction solution, allowing the obtained solution to stand and precipitate, and separating to obtain a solid which is 9-hydroxymethyl-10-imidazolanthracenehydrazone. A case that 9-hydroxymethyl-10-imidazolanthracenehydrazone has substantial in-vitro resistance activities on a plurality of human tumor cells, has substantial propagation inhibition activities on some tested tumor strains, has a good potential medicinal value, and is excepted to be used for the preparation of various antitumor medicines is found in the invention.