76 results about "Tromethamine" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a multi-effect composition containing ergothioneine, a preparation method of the multi-effect composition and application of the multi-effect composition in eye products. The multi-effect composition is prepared from ergothioneine, tromethamine and sodium hyaluronate according to the mass ratio of (0.5 to 10) to (1 to 5) to (0.5 to 3). According to the multi-effect composition containing the ergothioneine, the tromethamine in the composition can protect the stability of the ergothioneine under the conditions of illumination and high temperature; the ergosulfide can protect the activity of macromolecular sodium hyaluronate. The synergistic compatibility of the ergothioneine, the sodium hyaluronate and the tromethamine is utilized, so that the moisturizing effect and the eye protection effect of the composition can be remarkably improved. The ergothioneine-containing multi-effect composition provided by the invention has the effect of preventing cataract through specific components and proportions, and has the advantages of long-acting eye moistening and good stability.

To provide an ophthalmic product in which an ophthalmic composition is filled in a container in which a pressing deformation part is formed by using an elastic material, and although the ophthalmic composition contains chlorpheniramine, diphenhydramine or a salt thereof, adsorption of these components is suppressed.SOLUTION: An ophthalmic product comprising an ophthalmic composition and a container filled with the ophthalmic composition, wherein the container comprises a container body having a discharge port and a press-deforming part, and a cap, and the press-deforming part is formed using an elastic material, (A) one or more selected from the group consisting of chlorpheniramine, diphenhydramine, and pharmaceutically acceptable salts thereof, and (B) one or more selected from the group consisting of an amino acid and a salt thereof, glycyrrhizic acid and a salt thereof, a mucopolysaccharide and a salt thereof, trometamol and a salt thereof, ethylenediaminetetraacetic acid and a salt thereof, and a vitamin and a derivative thereof.SELECTED DRAWING: Figure 1

Compositions comprising cocrystals of acetylsalicylic acid and theanine that have been formulated with tromethamine are provided. Methods of preparing the compositions and methods of using the compositions with optional zinc or dipyridamole treatments are also provided.

The invention relates to the technical field of pharmaceutical analysis, and particularly discloses a method for detecting related substances in lodoxamide tromethamine. According to the invention, chromatographic conditions are optimized, a C18 column with hybrid particles charged on the surface is used as a chromatographic column, gradient elution is carried out under a specific mobile phase, and a high performance liquid chromatography capable of effectively separating lodoxamide tromethamine from nine related substances is provided, and the related substances comprise INT1, INT2, LODT-A, LODT-B, LODT-C, LODT-D, LODT-E, LODT-F and LODT-G. Through methodological research and verification of specificity, sensitivity and the like, the detection method for the impurities in lodoxamide tromethamine provided by the invention is high in sensitivity and accuracy, and relatively good in reproducibility and durability, each impurity peak does not interfere with a main peak, each chromatographic peak can be well separated, and the detection method is suitable for large-scale industrial production. And a reliable guarantee is provided for better controlling the quality of the lodoxamide tromethamine product.

The invention discloses a ketorolac tromethamine injection; specifically, the invention provides a pharmaceutical composition, which includes ketorolac tromethamine, L-cysteine, an osmotic pressure regulator, a pH regulator and water; the concentration of the L-cysteine ​​is ≥0.2 mg / mL; the pH of the pharmaceutical composition is 7.0-8.5. The injection of the invention is non-allergenic, non-hemolytic, low irritant, comparable to negative control saline, has higher stability and lower irritation, and has a wider range of applications.

The invention provides a preparation method of unsaturated fatty acid, which obviously reduces the residual amount of dioxin in grease through tromethamine treatment, effectively separates EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) through magnesium acetate precipitation, and improves the cycle use frequency of silver nitrate cycle use liquid through stannous chloride treatment and alkaline alumina treatment. And the unsaturated fatty acid separation capability of the silver nitrate recycling liquid is maintained.

The present invention are co-crystals of Uric Acid with increased solubility with respect to crystals of Uric Acid, suitable for the pharmaceutical use. The invention comprises co-crystals with L-lysine, L-arginine, ethylene diamine, and tromethamine as co-formers, pharmaceutical compositions thereof and their therapeutical use in the prevention or treatment of cerebrovascular diseases.

Pharmaceutical compositions, methods for treating various issues of the eyes, and methods of preparing such compositions are described. These pharmaceutical compositions may be for treating glaucoma, in preparation of eye surgery, during eye surgery, various post-op care (e.g., after cataract surgery, laser eye surgery, and the like), for treating dry eyes, and / or for promoting eyelash growth. These pharmaceutical compositions may comprise such active ingredients (APIs) as: timolol, latanoprost, brimonidine tartrate, dorzolamide, moxifloxacin HCl, dexamethasone PO4, phenylephrine HCl, lidocaine HCl, ketorolac tromethamine, bromfenac, prednisolone PO4, gatifloxacin, amniotic cytokine extract (ACE), prostaglandin E2 (PGE2), and combinations thereof.

The invention relates to the technical field of tromethamine synthesis, in particular to a continuous flow synthesis process of tromethamine. Comprising the following steps: adding nitromethane and a solvent A into a container A to obtain a solution A; adding a depolymerizing agent, a solvent B and paraformaldehyde into a container B to obtain a solution B; the first feeding pump and the second feeding pump respectively convey the solution A and the solution B to a micro-channel reactor at the same time for condensation reaction to obtain condensation reaction liquid; transferring the condensation reaction solution to an acidification kettle, and adding a quenching solution for reaction to obtain a quenching reaction solution; diluting the quenching reaction solution, adding a decolorizing agent, and filtering to obtain a decolorizing reaction solution; adding the decolorization reaction liquid and a solvent C into a hydrogenation reaction system by using a circulating pump, and carrying out hydrogenation reaction under the action of hydrogen and a catalyst to obtain hydrogenation reaction liquid; concentrating the hydrogenation reaction liquid to remove the solvent to obtain a tromethamine crude product, and refining the tromethamine crude product to obtain a tromethamine finished product. The method has the effects of low safety risk, continuous and smooth continuous flow pipeline and high product yield and purity.

The present invention discloses a method for preparing ketorolac tromethamine impurity E. The method for preparing compound E comprises the following steps: subjecting compound I to an amino acid condensation reaction in the absence of a solvent to produce compound E; the amino acid condensation reaction is carried out at a temperature of 120°C to 180°C. The method utilizes a solvent-free reaction, is simple to operate, and avoids the production of ester byproducts. High-purity compound E is obtained in good yield and meets the requirements for use as an impurity reference substance (purity greater than 95%).

The present invention relates to a dengue vaccine formulation comprising a tetravalent dengue virus composition comprising a live attenuated dengue virus serotype 1, a live attenuated dengue virus serotype 2, a live attenuated dengue virus serotype 3, and a live attenuated dengue virus serotype 4, at least one non-reducing disaccharide, at least one poloxamer, urea, at least one amino acid having a positively charged side chain at neutral pH, tromethamine, and human serum albumin.

Salts of R-ketorolac, including solid salts, such as crystalline salts of the meglumine and tromethamine salts R-ketorolac, are disclosed. Methods of preparing such salts, pharmaceutical compositions comprising salts, and methods of treating cancer with such salts are further provided.

The invention provides a torasemide injection and a preparation method thereof, the torasemide injection comprises the following components: torasemide, tromethamine, sodium hydroxide and water for injection, the pH value of the injection is 9.0-10.0, and the components do not contain a solubilizer. The injection provided by the invention has stable physicochemical properties, and the production process is simple.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The invention belongs to the field of medicine synthesis, and particularly relates to a preparation process of dexketoprofen trometamol. The preparation method comprises the following steps: dissolving 3-benzoyl phenyl acetonitrile in a solvent, adding a catalyst, a chiral ligand, a methylation reagent and alkali, irradiating with a light source for reaction, and after the reaction is completed, filtering and concentrating the dry solvent; adding water, sodium hydroxide and TBAB (Tetrabutylammonium Bromide) to react, and dropwise adding hydrochloric acid until a solid is separated out after the reaction is finished, so as to obtain dexketoprofen; the method comprises the following steps: dissolving dexketoprofen in a solvent, dropwise adding an alcoholic solution of trometamol, and after dropwise adding, cooling, crystallizing and filtering to obtain the product dexketoprofen trometamol. According to the present invention, the chiral center construction of ketoprofen is completed by using the chiral catalysis and photochemistry manner, and the ketoprofen is completely converted into the dexketoprofen, such that the complex route of splitting, racemization and re-splitting in the prior art is avoided, the operation process is simplified, the conversion rate is high, the chiral purity is high, the process is safe, green and environmentally friendly, and the high market competitiveness is provided.

The invention provides a bio-based efficient film-forming carrier for dissolving and stripping open and closed acnes, which is prepared from the following raw materials in percentage by weight: at least a phase A, a phase B and a phase C. The phase A at least comprises 0.1-1% of microcrystalline cellulose, 0.15-1% of cellulose gum, 3-8% of aureobasidium pullulans polysaccharide, 10-20% of alkaline blackhead exporting liquid, 2-5% of tromethamine and 30-80.25% of water; the phase B at least comprises 1-10% of caprylic / capric triglyceride and 0.5-5% of lauryl glucoside, and the phase C at least comprises 1-15% of cassava starch and 2-5% of 1, 2-pentanediol; the preparation method has the advantages that the reproducible bacterial nano cellulose is used as microcrystalline cellulose, so that a film forming system for dissolving and stripping open and closed acnes is milder and more effective, secondary injury to skin is avoided, and the film forming system is biodegradable, green and sustainable; the invention also provides a preparation method of the bio-based efficient film-forming carrier.

The invention relates to the field of pharmaceutical preparations, in particular to ketorolac tromethamine gel and a preparation method thereof, and the ketorolac tromethamine gel comprises the following components: 0.1-20% of ketorolac tromethamine, 0.5-20% of a film forming matrix, 0.001-5% of vitamin E, 0.1-5% of povidone, 5-80% of an organic solvent and the balance of water; through combined use of povidone and vitamin E, the ketorolac tromethamine gel has better chemical stability, better crystal inhibition effect, better permeation amount and permeation rate, better adhesiveness and longest skin retention time.

The invention relates to a lornoxicam injection preparation and a preparation method thereof, comprising the following steps: adding edetate disodium and tromethamine to water for injection, adding lornoxicam raw material medicine after dissolving, adding mannitol after dissolving, cooling while dissolving, and adding water for injection to the prescribed amount; wherein, before cooling, the temperature of the water for injection is maintained at 45-70° C. The lornoxicam injection preparation prepared by the invention has a fast dissolution speed, reduces the generation of by-products, ensures the stability and solubility of the finished product, and the sample preparation process is simple and convenient, and is suitable for large-scale production.

The invention discloses a tolvaptan sodium phosphate freeze-dried composition for injection and a preparation method of the tolvaptan sodium phosphate freeze-dried composition. The composition comprises tolvaptan sodium phosphate, tromethamine, disodium hydrogen phosphate and sodium dihydrogen phosphate, the molar ratio of the tolvaptan sodium phosphate to the tromethamine to the disodium hydrogen phosphate to the sodium dihydrogen phosphate is 1: (1.5-3.5): (2-4): (0.05-0.15). According to the invention, tromethamine is creatively adopted to replace cane sugar in the prior art to be used as a freeze-drying protective agent and a skeleton forming agent, so that the safety risks of high permeability, kidney burden, production pollution and the like possibly caused by the cane sugar are solved. In combination with a specific freeze-drying process comprising a pre-freeze-thawing step, the moisture content of the freeze-dried composition prepared by the invention can be lower than 0.3%, a stable freeze-dried cake-shaped structure is formed, and hydrolytic degradation of a main drug is effectively inhibited. Compared with the prior art, the composition provided by the invention has the beneficial effects of high safety, good stability and excellent product appearance.

The invention relates to the technical field of pharmaceutical preparations, in particular to a gadobutrol injection and a preparation method thereof. The gadobutrol injection comprises gadobutrol, sodium calcobutrol, arginine, a pH regulator and water for injection, the pH regulator is selected from one or more of citric acid, phosphoric acid, hydrochloric acid, acetic acid and tartaric acid, and the pH value of the injection is regulated to be about 6.6-8.0. The gadobutrol injection disclosed by the invention is good in stability, free gadolinium content meets requirements, tromethamine is prevented from being used, and liquid medicine is good in safety.

The invention provides transparent sunscreen gel and a preparation method thereof. The transparent sunscreen gel is prepared from the following raw materials in parts by weight: 10 to 20 parts of a sunscreen agent, 5 to 20 parts of a gelling agent, 0.01 to 0.15 part of a soft film forming agent, 0.5 to 5 parts of a neutralizing agent, 5 to 70 parts of water and 5 to 30 parts of an oil-phase solvent, wherein the neutralizer is composed of tromethamine and aminomethyl propanol, and the ratio of the tromethamine to the aminomethyl propanol is 1: (0.5-2); and the gelatinizing agent is an ionic gel HARMONIE SLEEKIONOC GEL, and the ionic gel is an ionic gel HARMONIE SLEEKIONOC GEL. The transparent sunscreen gel provided by the invention is not only good in sunscreen effect, but also good in stability and excellent in use experience, and the skin feels fresh and cool and is not sticky.

The invention relates to synthesis and application of a carboprost tromethamine chiral epoxy intermediate, and belongs to the technical field of chemical synthesis. The chiral epoxy intermediate compound as shown in the formula (I) is prepared from a compound as shown in the formula (II) and novel chiral sulfonium salt through catalytic asymmetric Corey-Chaykovsky reaction, reaction conditions are simple, and purification is easy. The invention also provides a method for preparing carboprost tromethamine from the compound as shown in the formula (I). The method is simple and convenient to operate, high in asymmetric selectivity and good in yield, the purification difficulty of the carboprost tromethamine is reduced, and the production cost is reduced.

The application discloses an arylpropionic acid non-steroidal anti-inflammatory drug preparation composition and a preparation method thereof. The composition is a solution preparation or a gel paste preparation containing arylpropionic acid non-steroidal anti-inflammatory drugs, and is characterized by containing arylpropionic acid non-steroidal anti-inflammatory drugs or isomers thereof and pharmaceutically acceptable solvents and adjuvants such as propylene glycol; wherein the mass / volume percentage of the arylpropionic acid non-steroidal anti-inflammatory drugs in the solution preparation ranges from 1 mg / ml to 40 mg / ml, and the volume percentage of the propylene glycol ranges from 50% to 100%; the mass percentage of the arylpropionic acid non-steroidal anti-inflammatory drugs in the gel paste preparation ranges from 1% to 10%, and the mass percentage of the propylene glycol ranges from 5% to 12%. The arylpropionic acid non-steroidal anti-inflammatory drugs in the prescription are in RS-configuration or derivatives, R-configuration or derivatives, S-configuration or derivatives, or a combination of the R-configuration or derivatives and the S-configuration or derivatives in any ratio; and the pH regulator is one or more of lysine, arginine, tromethamine, meglumine and the like.

The present invention relates to a dengue vaccine formulation comprising a tetravalent dengue virus composition comprising live attenuated dengue virus serotype 1, live attenuated dengue virus serotype 2, live attenuated dengue virus serotype 3, and live attenuated dengue virus serotype 4, at least one non-reducing disaccharide, at least one poloxamer, urea, at least one amino acid having a positively charged side chain at neutral pH, tromethamine, and human serum albumin.

The invention provides a method for detecting the residual quantity of micro or trace fosfomycin tromethamine, and belongs to the field of pharmaceutical analysis. According to the method, a low-capacity hydroxyl system cathode protection column and a high-capacity anion exchange separation column are used as chromatographic columns, an anion electrolysis regeneration suppressor is adopted, a sodium hydroxide or potassium hydroxide solution with the current of 36 mA to 44 mA and the current of 15 mmol / L to 17 mmol / L is used as leacheate, and the residual quantity of fosfomycin tromethamine is calculated according to the peak area by an external standard method. Compared with the prior art, the method has the advantages that the sensitivity is high, the quantitation limit of fosfomycin trometamol is as low as 0.0475 mu g / ml, the reproducibility is good, the operation is simple, the detection condition is mild, the application of detection equipment and instruments is wide, the source of leacheate is wide, the preparation is simple, and the like.

The present invention relates to an aqueous ophthalmic composition comprising spirolactone, cyclodextrin and tromethamine, preferably for topical application to the human eye. The present inventors advantageously dissolve spirolactone in the HP-gamma cyclodextrin excipient at a concentration of 0.1%, which dose has been demonstrated to be effective in the treatment of ocular surface defects. They also have successfully demonstrated that the spirolactone eye drops are stable for up to 9 months at 4 DEG C and achieve its efficacy within at least 6 months, and the formulation is well tolerant after multiple daily instillations within 7 days. In addition, the spirolactone eye drops provided by the invention accelerate healing of corneal wounds of rats, reduce corneal edema and inflammation, enhance epithelial integrity and improve nerve regeneration, and prompt recovery of corneal homeostasis. Thus, the invention also relates to the use of an aqueous ophthalmic composition for the treatment of ocular diseases and disorders.

The present invention relates to a method for preparing crystals of tromethamine or hydrochloride thereof, and crystals of tromethamine or hydrochloride thereof prepared using the preparation method. By lowering the temperature and maintaining same at a constant temperature, large crystal particles of tromethamine or hydrochloride thereof can be obtained uniformly and with high purity.

The invention belongs to the technical field of medicine detection, and particularly relates to a method for quantitatively detecting dexketoprofen trometamol injection and a related substance levoketoprofen of the dexketoprofen trometamol injection through high performance liquid chromatography. The method for quantitatively detecting the dexketoprofen trometamol injection and the related substance levoketoprofen of the dexketoprofen trometamol injection by the high performance liquid chromatography comprises the following steps: diluting the dexketoprofen trometamol injection with a solvent, and detecting by the high performance liquid chromatography, chromatographic conditions are as follows: a chromatographic column uses cellulose-tri-(4-methyl benzoate) as a filling agent; a mobile phase is an n-hexane-isopropanol-trifluoroacetic acid mixed solution; the flow velocity is 0.6 to 1.0 mL / min. The method for quantitatively detecting the dexketoprofen trometamol injection and the related substance levoketoprofen of the dexketoprofen trometamol injection through the high performance liquid chromatography, provided by the invention, is simple to operate and high in sensitivity, and has good specificity, system applicability, solution stability and chromatographic condition durability.

The invention discloses a preparation method of fosfomycin tromethamine, which comprises the following steps: in methanol, reacting fosfomycin levo-fosfomycin dextro-fosfomycin amine salt with tromethamine to generate fosfomycin tromethamine double salt; in methanol, fosfomycin levo-fosfomycin dextro-fosfomycin amine salt reacts with methanesulfonic acid to generate fosfomycin, and the fosfomycin reacts with the fosfomycin tromethamine double salt to obtain fosfomycin tromethamine. In the preparation process of the fosfomycin tromethamine, ring opening of the fosfomycin tromethamine is prevented by using a low-temperature reaction, and the pH is adjusted by using the fosfomycin tromethamine double salt, so that the pH of the fosfomycin tromethamine can be stably controlled, the content of impurities in the product can be effectively reduced, the product quality is improved, namely, the fosfomycin content is high, and the yield is high.

The invention relates to the technical field of pharmaceutical preparations, in particular to an iopamidol injection and a preparation method thereof. The iopamidol injection comprises iopamidol, glycine, sodium citrate, a pH regulator and water for injection, wherein the pH regulator enables the pH value of the injection to be 6.5-7.5. Compared with the prior art, the iopamidol injection disclosed by the invention is good in stability, can tolerate high-temperature sterilization, avoids the use of tromethamine and disodium calcium edetate, and is good in safety; compared with a reference preparation with the same specification, the iopamidol injection prepared by the invention has the advantages that the viscosity is reduced, and the compliance of clinical application is improved.