Ibuprofen medicinal composition

Abstract

The invention discloses an ibuprofen medicinal composition for injection. By adding tromethamine into solution of ibuprofen and arginine, the stability of the ibuprofen medicinal composition in clinical application is improved. Experiments prove that: after being diluted by the sodium chloride injection or glucose injection or sodium lactate Ringers injection, the composition solution can be stably stored for at least 12 hours.

Description

technical field

[0001] The invention discloses a pharmaceutical composition solution of ibuprofen, in particular to a pharmaceutical composition comprising ibuprofen, arginine and tromethamine, and belongs to the field of medicine. Background technique

[0002] Ibuprofen is a non-steroidal anti-inflammatory and analgesic drug commonly used in clinical practice. Its chemical name is 2-(4-isobutylphenyl)propionic acid. It has significant antipyretic, analgesic and anti-inflammatory effects. It mainly treats arthritis, Relieves various types of mild and moderate pains such as colds, dysmenorrhea, etc. The currently used ibuprofen is mainly a racemate. Existing studies have confirmed that S-ibuprofen has pharmacological activity in the human body, while R-ibuprofen is basically ineffective. After R-ibuprofen enters the human body, about 60 % converted to S-ibuprofen to have pharmacological activity. S-ibuprofen is gaining popularity in the pharmaceutical field due to its bette...

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