Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ibuprofen medicinal composition

A composition and drug technology, applied in the field of medicine, can solve the problems of poor water solubility of ibuprofen

Active Publication Date: 2011-02-23
茂裕环保科技南通有限公司
View PDF5 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The applicant has surprisingly found in a large number of experimental studies that by adding tromethamine to the solution of ibuprofen and arginine, not only the problem of poor water solubility of ibuprofen is solved, but also the prepared composition solution is chlorinated The stability in sodium injection or glucose injection or sodium lactate Ringer injection has been extremely significantly improved, obviously better than the ibuprofen injection that prior art provides in sodium chloride injection or glucose injection or sodium lactate ringer. Stability in Gelatin Injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ibuprofen medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ibuprofen 500g

[0025] Arginine 400g

[0026] Tromethamine 100g

[0027] Add water to 5L

[0028] Take 3L of water for injection, add arginine and ibuprofen, stir until dissolved, then add trometamol, stir to dissolve and mix evenly, add 0.2% (2g / L) medicinal activated carbon, stir for 30min, filter to remove drug Use carbon to cool to room temperature, then add water to 5 L, fine filter with a 0.22 μm microporous membrane, and obtain the solution of the composition of the present invention. The resulting solution had a pH of 8.3 and a concentration of 100 mg / mL.

[0029] The ibuprofen pharmaceutical composition solution is packaged in ampoules, sterilized at 121° C. for 15 minutes, packaged and then stored, and divided into 1000 bottles. In clinical use, it is diluted to the required concentration with physiological saline or glucose solution.

Embodiment 2

[0031] Ibuprofen 500g

[0032] Arginine 500g

[0033] Tromethamine 5g

[0034] Add water to 5L

[0035]Take 2.5L of water for injection, add arginine and ibuprofen, stir until dissolved, then add tromethamine, stir to dissolve and mix evenly, add 0.2% medicinal active carbon, stir for 30min, filter to remove medicinal carbon, and then Continue to add water for injection to dilute to 5 L, fine filter with a 0.22 μm microporous membrane, and obtain the composition solution of the present invention. The concentration is 100mg / mL.

[0036] Injection was prepared according to the method of Example 1.

Embodiment 3

[0038] Ibuprofen 500g

[0039] Arginine 1000g

[0040] Tromethamine 25g

[0041] Propylene glycol 100g

[0042] Dilute to 5L with water

[0043] Take 3L of water for injection, add arginine, ibuprofen, and tromethamine, stir until dissolved, then add propylene glycol, stir to mix evenly, add 0.2% (2g / L) medicinal activated carbon, stir for 30min, filter to remove Medicinal carbon, then continue to add water for injection to dilute to 5L, fine filter with a 0.22 μm microporous membrane, and obtain the composition solution of the present invention. The concentration is 100mg / mL.

[0044] Injection was prepared according to the method of Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ibuprofen medicinal composition for injection. By adding tromethamine into solution of ibuprofen and arginine, the stability of the ibuprofen medicinal composition in clinical application is improved. Experiments prove that: after being diluted by the sodium chloride injection or glucose injection or sodium lactate Ringers injection, the composition solution can be stably stored for at least 12 hours.

Description

technical field [0001] The invention discloses a pharmaceutical composition solution of ibuprofen, in particular to a pharmaceutical composition comprising ibuprofen, arginine and tromethamine, and belongs to the field of medicine. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory and analgesic drug commonly used in clinical practice. Its chemical name is 2-(4-isobutylphenyl)propionic acid. It has significant antipyretic, analgesic and anti-inflammatory effects. It mainly treats arthritis, Relieves various types of mild and moderate pains such as colds, dysmenorrhea, etc. The currently used ibuprofen is mainly a racemate. Existing studies have confirmed that S-ibuprofen has pharmacological activity in the human body, while R-ibuprofen is basically ineffective. After R-ibuprofen enters the human body, about 60 % converted to S-ibuprofen to have pharmacological activity. S-ibuprofen is gaining popularity in the pharmaceutical field due to its bette...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61P29/00A61K47/18A61K31/192A61K31/205
Inventor 郝守祝
Owner 茂裕环保科技南通有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com