32 results about "Sodium Chloride Injection" patented technology

The invention discloses a liquid chromatography method for measuring 5-hydroxymethylfurfural in a calcium gluconate and sodium chloride injection. The method comprises the following steps: measuring the calcium gluconate and sodium chloride injection as a test solution; weighing 5-hydroxymethylfurfural, and adding water to dilute the 5-hydroxymethylfurfural to form a reference solution; carrying out continuous sample introduction on the liquid chromatograph by using the reference substance solution to obtain a system applicability solution chromatogram; when the chromatogram of the applicable solution of the system meets the standard, measuring the test solution and the reference solution, respectively injecting the test solution and the reference solution into a liquid chromatograph, and recording the chromatograms; the content of 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection is obtained through a 5-hydroxymethylfurfural content calculation formula. The method has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can quantitatively detect 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection, so that the safety of clinical medication of the calcium gluconate and sodium chloride injection is improved.

The invention discloses a tinidazole sodium chloride injection difficult to crystallize at low temperature as well as a preparation method and application of the tinidazole sodium chloride injection. Belongs to the technical field of pharmaceutical preparations. The preparation method of the tinidazole sodium chloride injection is adjusted and improved, the tinidazole at a specific nano level is prepared by performing high-pressure homogenization treatment on the tinidazole, and then the tinidazole is dissolved in a specific solvent to prepare a tinidazole solution. The preparation method comprises the following steps: preparing a tinidazole solution, pretreating the tinidazole solution with a polyvinyl alcohol modified solution, and finally mixing the tinidazole solution with a sodium chloride solution to prepare the tinidazole sodium chloride injection, so that the temperature stability of the injection is effectively improved, and the injection is not easy to crystallize at low temperature; according to the invention, the content of tinidazole in the injection is ensured not to be greatly changed, the number of particles is kept at a certain level, the quality of the product is effectively improved, and the safety is improved.

The invention discloses a preparation process of a high-stability dipyridamole sodium chloride injection. The preparation process comprises the following steps: S1, weighing raw materials and auxiliary materials: weighing 1g of dipyridamole, 90g of sodium chloride, 10-30g of sodium citrate and 30-70g of propylene glycol; s2, adding water for injection accounting for 70% of the prescription dosage into a liquid preparation tank, then adding sodium chloride, sodium citrate and propylene glycol accounting for the prescription dosage, and completely dissolving in a stirring state; s3, adding a proper amount of a hydrochloric acid solution, adjusting the pH value to 2.5, adding dipyridamole according to the prescription amount, and dissolving dipyridamole in a stirring state; s4, adding a proper amount of a sodium hydroxide solution, adjusting the pH value to 4.0, and fixing the volume to the prescription dosage by using the water for injection; s5, filtering the prepared solution, filling the filtered liquid medicine into a glass bottle, filling nitrogen into the bottle, plugging and capping; s6, sterilizing the filled sample; the stability of the prepared sample is obviously higher than that of a commercially available preparation, DP-II degradation impurities are avoided, obvious advantages are achieved, and the safety risk in the use process of the product can be obviously reduced.

The application belongs to the technical field of medicine, and relates to a compound composition, a preparation method and application, in particular to a compound sodium salicylate composition for treating acute pancreatitis and a preparation method. The compound sodium salicylate composition comprises quercetin, diammonium glycyrrhizinate and sodium salicylate, wherein the mass ratio of quercetin, diammonium glycyrrhizinate and sodium salicylate is 1-5:5-20:50-200. When the compound sodium salicylate composition is an injection, it comprises quercetin, diammonium glycyrrhizinate, sodium salicylate, 1,2-propanediol, sodium bisulfite, dimethyl sulfoxide and 0.9% sodium chloride injection. The volume ratio of 1,2-propanediol and dimethyl sulfoxide in the injection is 14-20% and 0.25-1% respectively; and the mass / volume ratio of sodium bisulfite in the injection is 0.1-0.3%. The compound sodium salicylate composition can significantly reduce amylase, lipase, IL-6 and IL-1beta, and can be used for preparing a medicine for treating pancreatitis.

The invention discloses a novel pre-filled flusher which comprises an outer sleeve and a piston arranged in the outer sleeve and further comprises a locking protective cap and an axial anti-falling mechanism. The locking protective cap is arranged at a pipe opening in the front end of the outer sleeve, so that a closed container inner cavity is formed by the piston, the outer sleeve and the locking protective cap, and 0.9% sodium chloride injection is filled in the container inner cavity; and the axial anti-falling mechanism comprises a pre-tightening ring and a drawstring. Reliable mechanical locking is provided for the front end of the catheter flusher through the locking protective cap in threaded connection, on the basis, continuous pressing force is applied to the locking protective cap through the axial anti-disengaging mechanism, thread loosening possibly caused by transportation vibration is effectively counteracted, and the transportation safety can be effectively improved through double-sealing guarantee. Moreover, the axial anti-falling mechanism can be unlocked only by rotating the rotating ring without additional tools, so that the operation process is simplified, and the operation convenience is improved.

The invention relates to the technical field of drug analysis and detection, and provides a method for detecting 1, 2, 4-triazole in fluconazole sodium chloride injection, which adopts high performance liquid chromatography. The specific conditions of the high performance liquid chromatography are as follows: a solvent is a water-acetonitrile mixed solution with the volume ratio of 95: 5; the mobile phase comprises a mobile phase A and a mobile phase B, the mobile phase A is water, and the mobile phase B is acetonitrile; the flow velocity is 1.0 mL / min; octadecylsilane chemically bonded silica is used as a filling agent of a chromatographic column; the column temperature is 30 DEG C; the sample injection volume is 100 microliters; performing gradient elution; and the detection wavelength is 195 nm. The method has the advantages that the content of 1, 2, 4-triazole in the fluconazole sodium chloride injection can be quantitatively and accurately determined without derivation reaction, the unification of operation convenience and detection accuracy is realized, and reliable technical support is provided for quality control of the fluconazole sodium chloride injection.

The invention provides amniotic membrane preserving fluid and application thereof. The amniotic membrane preserving fluid is prepared from the following components: sodium chloride injection, glycerol, trehalose and sodium hyaluronate, the volume ratio of the sodium chloride injection to the glycerol is (8-24): (8-18); the volume mass ratio of the sodium chloride injection to the trehalose is (8-24): (0.5-6); the mass ratio of the trehalose to the sodium hyaluronate is (0.5-6): (0.006-0.15). Compared with an existing amniotic membrane preservation method, the amniotic membrane preservation liquid can be stored at a high temperature, so that the risk that the amniotic membrane is frostbitten can be effectively reduced, even if the amniotic membrane is stored at the high temperature, the amniotic membrane can have high biological activity and multidirectional differentiation potential, and various natural active ingredients of the amniotic membrane can be effectively reserved. Meanwhile, the amniotic membrane preserving fluid is simple in component, has good compatibility with amniotic membrane tissues, does not generate adverse effects on the structure and the function of the amniotic membrane, and has higher biological safety.

The invention discloses a method for detecting oxalate in calcium gluconate and sodium chloride injection, and relates to the technical field of drug analysis and detection. The detection method comprises the following steps: S1, preparing a test solution and a reference solution; s2, adding hydrochloric acid and high-purity zinc into the test solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the test solution, heating until boiling, immediately cooling, and adding hydrochloric acid and a potassium ferricyanide solution to obtain a first mixed solution; adding hydrochloric acid and high-purity zinc into the reference substance solution, standing for 4-6 minutes, adding a phenylhydrazine hydrochloride solution into the reference substance solution, heating until boiling, immediately cooling, and adding a hydrochloric acid solution serving as a potassium ferricyanide solution to obtain a second mixed solution; and judging whether the content of oxalate in the test solution exceeds the standard or not by comparing the color depth of the first mixed solution and the color depth of the second mixed solution. Oxalates in the calcium gluconate and sodium chloride injection can be visually and rapidly detected through colorimetry, specificity and durability are good, and operation is easy and convenient.

The invention relates to a CAR-NK (chimeric antigen receptor-natural killer) cell cryopreservation solution for clinical use as well as a preparation method and application thereof. The CAR-NK cell freezing medium disclosed by the invention is prepared from a washing solution, a dextran 40 glucose injection and Cryostat CS10, or is prepared from the washing solution, human serum albumin and Cryostat CS10; wherein the washing liquid is prepared from sodium chloride injection and human serum albumin. The cryopreservation liquid disclosed by the invention is used for cryopreserving CAR-NK cells, does not have the problem of cell agglomeration, and can effectively maintain the viability and vitality of the cells; the cryopreservation liquid is simple in component, is in a GMP level or a medicine level, can be directly infused back to a human body, is convenient to prepare and easy to prepare in a large scale, and saves the production and manufacturing cost.

The invention relates to the technical field of biological medicine, in particular to a glycerin fructose sodium chloride injection and a preparation method thereof, and every 1000 mL of the glycerin fructose sodium chloride injection comprises 80-120 g of glycerin, 40-60 g of fructose, 7-11 g of sodium chloride, 0.6-2.0 g of lecithin, 0.1-0.4 g of organic acid and water for injection. The preparation method comprises the following steps: dispersing lecithin in water for injection at 50-60 DEG C, then adding glycerol, sodium chloride and organic acid, adding fructose after the system is cooled to 40 DEG C or below, finally fixing the volume, adjusting the pH value to 4.0-4.5, and carrying out two-stage filtration and moist heat sterilization. According to the invention, through compounding of lecithin and organic acid, generation of a fructose degradation product 5-hydroxymethylfurfural can be significantly inhibited.

The invention discloses a method for detecting the concentration of NaCl in a sodium chloride injection intermediate, and relates to the technical field of PAT detection. The method comprises the following steps: preparing samples with different NaCl concentrations; respectively collecting the Raman spectrum of each sample at a constant temperature of 25 DEG C, and establishing a NaCl concentration quantitative model; the method comprises the following steps: extracting samples with typical NaCl concentrations from samples, continuously changing the temperatures of the samples, collecting Raman spectrums at different temperatures, and establishing a quantitative relation model of the temperatures and the Raman spectrums for each typical NaCl concentration; acquiring the actually measured temperature and the actually measured Raman spectrum of the sodium chloride injection intermediate to be detected; on the basis of the relationship between the temperature and the Raman spectrum in the quantitative relationship model, correcting the Raman spectrum at the actually measured temperature to be at the constant temperature of 25 DEG C to obtain a corrected Raman spectrum; and obtaining the NaCl concentration corresponding to the corrected Raman spectrum based on the relationship between the NaCl concentration and the Raman spectrum in the NaCl concentration quantitative model. The real-time, accurate and stable detection of the concentration of the intermediate NaCl of the sodium chloride injection is realized.

The invention relates to a freezing medium and a freezing method for universal CAR (chimeric antigen receptor) cells. The cryopreservation liquid comprises a compound electrolyte injection, a human serum albumin injection, a sodium chloride injection, a dextran 40 glucose injection, a glucose injection, dimethyl sulfoxide and trehalose. The cell cryopreservation process is deeply analyzed, the specific cell cryopreservation liquid and the cryopreservation method are designed, all the components of the cryopreservation liquid are synergistic, the cryopreservation liquid can adapt to the specific cooling process, cell damage in the cryopreservation process is effectively reduced, the activity of the cryopreserved cells is effectively kept, the cryopreservation liquid can be directly used for reinfusion of patients, a specific sectional programmed cooling program is adopted, and the cell cryopreservation process is simplified. The cell cryopreservation device can further adapt to different cryopreservation volumes, so that the cryopreservation effect is further improved, the survival rate of cells is effectively guaranteed, and the cryopreserved cells still keep good cell activity.

The present invention relates to a special cryopreservation solution for hepatocytes and a preparation method therefor, and belongs to the technical field of cell cryopreservation and thawing. The special cryopreservation solution for hepatocytes comprises the following components: a cryoprotectant, a biofilm protectant and an antioxidant. The biofilm protectant comprises an inhibitor Y27632, glycerol, human serum albumin, collagen and a dextran 40 sodium chloride injection. The special cryopreservation solution for hepatocytes of the present invention can effectively improve the hydrophobicity of the biofilm and reduce the fluidity of the biofilm, so that the damage to the biofilm of hepatocytes caused by ice crystals during the freezing and thawing processes is minimized, and the cell viability of hepatocytes after thawing is significantly improved.

The invention relates to the technical field of foreign matter detection, and particularly discloses a fluconazole sodium chloride injection filling foreign matter detection device which comprises a foreign matter detection production line used for fluconazole sodium chloride injection filling, and the foreign matter detection production line is provided with a first detection station, a second detection station and an empty bottle conveying line. The first detection station and the second detection station are used for detecting empty bottles on the empty bottle conveying line, and both the first detection station and the second detection station are used for image detection; the first detection station detects the bottle bottom of an empty bottle to obtain a bottle bottom image, the second detection station comprises a left detection link and a right detection link which are used for obtaining a side body image, a side upper body image and a side lower body image of the empty bottle, and the second detection station obtains mirror images of the side body image, the side upper body image and the side lower body image of the empty bottle based on an empty bottle rotating assembly; and performing mirror image combination analysis on the side body image, the side upper body image and the side lower body image of the left detection link and the side body image, the side upper body image and the side lower body image of the right detection link.

The invention discloses a preparation method and application of cefoperazone sodium and sulbactam sodium for injection, and relates to the field of preparation methods of cefoperazone sodium and sulbactam sodium, and the preparation method comprises preparation of cefoperazone sodium and preparation of a mixed solution. The preparation of the mixed solution comprises the following steps: weighing sulbactam sodium and the prepared cefoperazone sodium, adding the sulbactam sodium and the prepared cefoperazone sodium into a sodium chloride injection, dissolving, adding a phosphate buffer solution, filtering, adding valine into the solution, dispersing, and filtering to obtain the mixed solution. Sequentially carrying out freeze-drying treatment, drying, crushing, screening and re-drying on the dispersed mixed solution to obtain the cefoperazone sodium sulbactam sodium for injection. The mass ratio of the cefoperazone sodium to the sulbactam sodium is (1-5): 1. The valine is added into the mixed solution and the process is optimized, so that the valine and the cefoperazone sodium can form hydrogen bonds and electrostatic interaction, and the purpose of improving the stability of the cefoperazone sodium sulbactam sodium for injection with high cefoperazone sodium content is achieved.

The invention relates to a method for detecting the sealing performance of a morphonidazole sodium chloride injection packaging container by using a high-voltage discharge method. The method comprises the following steps: (1) preparing a positive sample and a negative sample; (2) performing high-voltage discharge leak detection on the positive sample and the negative sample to obtain response values of the positive sample and the negative sample; and (3) taking the average value of the sum of the minimum response value of the positive sample, the average value of the response values of the negative sample and the standard deviation three times of the response values of the negative sample as a standard value, and carrying out high-voltage discharge leak detection on the to-be-detected sample by adopting the standard value. According to the method, the average value of the sum of the minimum response value of the positive sample, the average value of the response values of the negative sample and the standard deviation of three times of the response values of the negative sample is used as the standard value, so that the false detection rate of leakage-free products is reduced, the waste of the products is reduced, and the cost is reduced; meanwhile, detection of leaked products is guaranteed, and product quality and clinical medication safety are guaranteed.

The utility model relates to a lamp inspection instrument for calcium gluconate sodium chloride injection, which comprises a base and an operation platform positioned on the base, the operation platform comprises a conveying mechanism, a detection mechanism, an illumination mechanism and an image acquisition mechanism, a through hole is transversely arranged in the middle of the operation platform, and the conveying mechanism is positioned in the through hole. The conveying mechanism comprises a first conveying belt and a second conveying belt, the tail end of the first conveying belt is adjacent to the head end of the second conveying belt, the first conveying belt comprises a clamping groove, a conveying belt, a driving shaft, a positioning shaft, a first driving structure and a limiting device, and the limiting device comprises a limiting plate, a guide groove, a sliding block and a plurality of connecting blocks. According to the lamp inspection instrument for the calcium gluconate and sodium chloride injection, the stability of injection bottle bodies in the conveying process is improved, and the situation that the bottle bodies turn over laterally, and the detection progress of the lamp inspection instrument is reduced is avoided.

The invention discloses a preserving fluid for an umbilical cord mesenchymal stem cell preparation. The preserving fluid comprises 0.9% sodium chloride injection, human serum albumin and thymopentin for injection. The preserving fluid can stably preserve stem cells for 72 hours at the room temperature of 15-30 DEG C, and the cell viability is maintained to be 80% or above; meanwhile, the preserving fluid is simple in component, does not contain complex additives such as a pH buffering agent and an antioxidant, and is simple and convenient in preparation process and easy in cost control.

The invention discloses a disposable transfusion air filter and belongs to medical instruments. At present, air filtration of domestic infusion apparatuses generally adopts a membrane technology, and a satisfactory filtration effect on too fine foreign matters or bacteria and viruses is difficult to achieve. According to the disposable infusion air filter, air containing suspended solids (PM2.5, PM10, NO2, SO2, O3, CO, bacteria, viruses and the like) can enter a liquid medicine bottle after being humidified, adsorbed, precipitated and purified through filtration liquid (0.9% sodium chloride injection or 5% glucose injection), so that the medication safety of a patient is guaranteed at a higher level, and the blank of the project in China is filled up. The disposable infusion air filter is only used for filtering air entering a liquid medicine bottle during infusion, and a conventional infusion apparatus needs to be used in a matched mode during infusion. Technical characteristics are shown in Figure 1 in the specification.

The present disclosure relates to the field of biomedicine, and discloses a nutritional composition for intervention or treatment of autism and a preparation method thereof, aiming to solve the problems of safety, compliance and insufficient targeting mechanism of existing intervention programs for social impairment of autism. The composition comprises leucine, isoleucine and valine in a molar ratio of 1:1:1, with a total concentration of 0.753 mg / kg of body weight, in the form of oral liquid, and a pH of 6.87.4. The preparation method comprises weighing the amino acids according to the molar ratio, dissolving them in 0.9% sodium chloride injection, filtering, dispensing and sealing. The present application can safely and effectively improve the social impairment of autism patients and plays a role by up-regulating the expression of MyT1L in the hippocampus.

This invention relates to the field of pharmaceutical analysis technology, and provides a method for detecting enantiomers in peramivir sodium chloride injection. The method employs high-performance liquid chromatography (HPLC), with the following chromatographic conditions: a column packed with α1-acidic glycoprotein-bonded silica gel; a mobile phase consisting of a mixture of 0.02 mol / L ammonium dihydrogen phosphate solution and 0.02 mol / L diammonium hydrogen phosphate solution at a volume ratio of 45:55 to 55:45; a detection wavelength of 205 nm; a flow rate of 0.25 to 0.35 mL / min; and a column temperature of 18 to 22 °C. Before detection, a test solution, a reference solution, and a system suitability solution are prepared, and each solution is accurately injected into the HPLC system. The chromatograms are recorded, and the enantiomer content is calculated. The advantages of this invention are: simple operation, no sodium chloride interference, and accurate quantitative detection of enantiomers in peramivir sodium chloride injection.

The invention discloses a device for detecting the content of a sodium chloride injection intermediate, and relates to the technical field of pharmacy. Comprising a detection cup, a Raman spectrum detector, a U-shaped pipe and a gas filtering device, an opening is formed in the lower portion of the detection cup, the opening is sealed through a cover plate, a liquid inlet pipe, a liquid outlet pipe and the Raman spectrum detector are installed on the cover plate, a Raman probe of the Raman spectrum detector upwards extends into the detection cup, and the U-shaped pipe is connected with the gas filtering device. A U-shaped pipe is further installed on the cover plate, one end of the U-shaped pipe extends to the upper portion in the detection cup, and the other end of the U-shaped pipe is located outside the detection cup and provided with a gas filtering device; the quantity of bubbles generated in the process that liquid enters the detection device can be reduced, the situation that the bubbles are attached to the outer surface of a Raman probe of the Raman spectrum detector to affect the detection accuracy is avoided, meanwhile, the liquid inlet time is shortened, and the detection efficiency is improved.

The utility model provides a push-and-pull tool for an injector, which belongs to the technical field of push-and-pull tools and comprises a mounting seat, a first power source component, a second power source component, an assembly part, a clamping part, a sliding part, a driving component and a bearing part. The first power source assembly is arranged on the mounting base and comprises a connecting piece. The second power source assembly is fixedly arranged on the connecting piece, and the second power source assembly is provided with a load sliding table. And the assembly part is fixedly connected with the load sliding table. And the clamping piece is fixedly connected with the assembly piece. The sliding part is in sliding connection with the assembly part. The driving assembly is used for driving the sliding part to slide. And the bearing piece is connected with the mounting seat. According to the push-and-pull tool for the injector, the problem that when a medical worker extracts sodium chloride injection from a PP bottle through the injector, a needle head on the injector may puncture the medical worker can be solved.

This invention discloses a water softening system, relating to the technical field of water softening systems. It includes a bottom support assembly, with a water softening component mounted on top. The top of the water softening component is connected to an evaporator via a pipe. The system, in conjunction with the water softening component, filter screen, and salt filter, performs preliminary filtration of the incoming raw water. Then, sodium chloride is injected into the catalyst injection chamber through the sodium chloride injection end. The presence of two convection devices at an angle increases the dissolved oxygen required during the delivery of the sodium chloride aqueous solution. Calcium ions are then adsorbed through a calcium ion adsorption alumina membrane. A resistor, connected to a controller and an internal power supply, electrically connects the system, causing an induction coil to rotate under the influence of a drive motor. This generates a magnetic field at the bottom of the water softening chamber, adsorbing calcium, sodium, and magnesium ions in the raw water, effectively improving the water softening efficiency.

The utility model discloses a device for detecting the content of a sodium chloride injection intermediate, and relates to the technical field of pharmacy. Comprising a detection cup, a Raman spectrum detector, a U-shaped pipe and a gas filtering device, an opening is formed in the lower portion of the detection cup, the opening is sealed through a cover plate, a liquid inlet pipe, a liquid outlet pipe and the Raman spectrum detector are installed on the cover plate, a Raman probe of the Raman spectrum detector upwards extends into the detection cup, and the U-shaped pipe is connected with the gas filtering device. A U-shaped pipe is further installed on the cover plate, one end of the U-shaped pipe extends to the upper portion in the detection cup, and the other end of the U-shaped pipe is located outside the detection cup and provided with a gas filtering device; the quantity of bubbles generated in the process that liquid enters the detection device can be reduced, the bubbles are prevented from being attached to the outer surface of a Raman probe of the Raman spectrum detector to influence the detection accuracy, meanwhile, the liquid inlet time is shortened, and the detection efficiency is improved.

The application relates to the field of biological medicine, in particular to a glycerol fructose sodium chloride injection and a preparation method thereof. The glycerol fructose sodium chloride injection contains 80-120 g of glycerol, 40-60 g of fructose, 7-11 g of sodium chloride, 0.6-2.0 g of lecithin, 0.1-0.4 g of organic acid and injection water per 1000 mL. The lecithin is dispersed in the injection water at 50-60 DEG C first, then the glycerol, the sodium chloride and the organic acid are added, the fructose is added after the system is cooled to below 40 DEG C, finally the volume is fixed and the pH is adjusted to 4.0-4.5, and the two-stage filtration and wet heat sterilization are carried out to obtain the glycerol fructose sodium chloride injection. The compound of the lecithin and the organic acid can significantly inhibit the generation of the fructose degradation product 5-hydroxymethyl furfural.

The invention discloses a hypertonic muscle injection for an immune wake-up therapy and a preparation method of the hypertonic muscle injection, and relates to the medical field, the injection is hypertonic glucose with the concentration of 15-25%, and is only composed of anhydrous dextrose and water for injection; the injection is used for intramuscular injection, anatomical local injection, traditional Chinese medicine acupoint injection and focus part injection based on a targeting principle, and intravenous injection is strictly prohibited; compared with the prior art, the invention has the beneficial effects that controllable micro-injury is caused by the hypertonic glucose or sodium chloride injection, the central immune system is awakened, lesions are automatically cleared by autoimmunity, various diseases can be treated at the same time, and the defect of single target spot is overcome; the preparation only consists of sugar / salt and water for injection, and has no toxic or side effect and no drug resistance; raw materials are easy to obtain, the process is simple, cost is extremely low, and patient burden is remarkably relieved; the medicine is simple and convenient to operate, wide in adaptation disease, capable of being combined with any existing therapy and extremely high in clinical value.

This invention relates to an injectable paclitaxel formulation designed to enhance solubility and stability. The formulation comprises paclitaxel at a concentration of 6 to 12 mg / mL, with Vitamin E Polyethylene Glycol Succinate (TPGS) serving as a surfactant and solubilizer in concentrations ranging from 300 mg / mL to 600 mg / mL. Polyethylene glycol 300 (PEG 300) acts as a stabilizer, and citric acid is included as a buffering agent, along with water for injection. The formulation is stable at room temperature for about 27 hours after dilution in infusion liquids such as 5% dextrose injection USP, 0.9% sodium chloride injection USP, 5% dextrose and 0.9% sodium chloride injection USP and 5% dextrose in Ringer's Injection solutions. The diluted formulation forms a nano micellar solution with micelles ranging from 10 to 100 nm in size, ensuring a stable and clear solution for intravenous administration of paclitaxel, thus improving safety and efficacy.

The invention discloses a liquid chromatography method for measuring oxalic acid in a calcium gluconate and sodium chloride injection. The method comprises the following steps: preparing a reference substance stock solution; preparing a reference solution; preparing a test solution; preparing a system applicability solution; measuring the system applicability solution and injecting the system applicability solution into a liquid chromatograph to obtain a system applicability solution chromatogram; after it is verified that the overall performance of the chromatographic system meets the requirements, the test solution and the reference solution are measured and injected into a liquid chromatograph, and chromatograms are recorded; obtaining the peak area of the oxalic acid in the test solution and the peak area of the oxalic acid in the reference solution from the chromatogram, and combining the marked concentration of calcium gluconate in the test solution, the weighing amount of the oxalic acid in the reference solution, the purity of the oxalic acid reference substance, the dilution ratio of the test solution and the dilution ratio of the reference solution; the percentage of the oxalic acid content is obtained through an oxalic acid content calculation formula. The method can be used for rapidly and accurately measuring the content of oxalic acid in the calcium gluconate and sodium chloride injection with high sensitivity.

The invention provides a nasal-absorbed stem cell exosome preparation and a preparation method thereof, the nasal-absorbed stem cell exosome preparation comprises an exosome and a matrix solution, and the matrix solution comprises 0.9% of sodium chloride injection, 5-10% of human serum albumin, 10-20% of dextran 40 glucose injection, 20-30% of glycerin fructose sodium chloride injection, 20-50 [mu] g / ml of ganglioside sodium and 4-8 [mu] g / ml of edaravone injection. The stem cell exosome preparation prepared from the stem cell exosome and the matrix solution can be preserved at-20 DEG C for 12 months, and can be preserved at 2-8 DEG C for 15 days after thawing, the number of the exosomes, surface protein expression and the form of vesicles can be well maintained, and the stem cell exosome preparation is clear and safe in component. Exosome administration is carried out through nasal mucosa to enter brain tissue parts, endogenous neural stem cells of organisms are activated and nourished, a regeneration microenvironment is established, nerve injury repair is promoted, and the exosome is used for preventing, treating and improving cognitive impairment and traumatic brain injury of senile dementia. The preparation is simple and convenient to prepare, small in toxic and side effects and convenient to dose.