13 results about "Sodium Chloride Injection" patented technology

The invention discloses a liquid chromatography method for measuring 5-hydroxymethylfurfural in a calcium gluconate and sodium chloride injection. The method comprises the following steps: measuring the calcium gluconate and sodium chloride injection as a test solution; weighing 5-hydroxymethylfurfural, and adding water to dilute the 5-hydroxymethylfurfural to form a reference solution; carrying out continuous sample introduction on the liquid chromatograph by using the reference substance solution to obtain a system applicability solution chromatogram; when the chromatogram of the applicable solution of the system meets the standard, measuring the test solution and the reference solution, respectively injecting the test solution and the reference solution into a liquid chromatograph, and recording the chromatograms; the content of 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection is obtained through a 5-hydroxymethylfurfural content calculation formula. The method has the advantages of strong specificity, high sensitivity, good precision, strong durability and the like, and can quantitatively detect 5-hydroxymethylfurfural in the calcium gluconate and sodium chloride injection, so that the safety of clinical medication of the calcium gluconate and sodium chloride injection is improved.

The application belongs to the technical field of medicine, and relates to a compound composition, a preparation method and application, in particular to a compound sodium salicylate composition for treating acute pancreatitis and a preparation method. The compound sodium salicylate composition comprises quercetin, diammonium glycyrrhizinate and sodium salicylate, wherein the mass ratio of quercetin, diammonium glycyrrhizinate and sodium salicylate is 1-5:5-20:50-200. When the compound sodium salicylate composition is an injection, it comprises quercetin, diammonium glycyrrhizinate, sodium salicylate, 1,2-propanediol, sodium bisulfite, dimethyl sulfoxide and 0.9% sodium chloride injection. The volume ratio of 1,2-propanediol and dimethyl sulfoxide in the injection is 14-20% and 0.25-1% respectively; and the mass / volume ratio of sodium bisulfite in the injection is 0.1-0.3%. The compound sodium salicylate composition can significantly reduce amylase, lipase, IL-6 and IL-1beta, and can be used for preparing a medicine for treating pancreatitis.

The invention discloses a method for detecting the concentration of NaCl in a sodium chloride injection intermediate, and relates to the technical field of PAT detection. The method comprises the following steps: preparing samples with different NaCl concentrations; respectively collecting the Raman spectrum of each sample at a constant temperature of 25 DEG C, and establishing a NaCl concentration quantitative model; the method comprises the following steps: extracting samples with typical NaCl concentrations from samples, continuously changing the temperatures of the samples, collecting Raman spectrums at different temperatures, and establishing a quantitative relation model of the temperatures and the Raman spectrums for each typical NaCl concentration; acquiring the actually measured temperature and the actually measured Raman spectrum of the sodium chloride injection intermediate to be detected; on the basis of the relationship between the temperature and the Raman spectrum in the quantitative relationship model, correcting the Raman spectrum at the actually measured temperature to be at the constant temperature of 25 DEG C to obtain a corrected Raman spectrum; and obtaining the NaCl concentration corresponding to the corrected Raman spectrum based on the relationship between the NaCl concentration and the Raman spectrum in the NaCl concentration quantitative model. The real-time, accurate and stable detection of the concentration of the intermediate NaCl of the sodium chloride injection is realized.

The present disclosure relates to the field of biomedicine, and discloses a nutritional composition for intervention or treatment of autism and a preparation method thereof, aiming to solve the problems of safety, compliance and insufficient targeting mechanism of existing intervention programs for social impairment of autism. The composition comprises leucine, isoleucine and valine in a molar ratio of 1:1:1, with a total concentration of 0.753 mg / kg of body weight, in the form of oral liquid, and a pH of 6.87.4. The preparation method comprises weighing the amino acids according to the molar ratio, dissolving them in 0.9% sodium chloride injection, filtering, dispensing and sealing. The present application can safely and effectively improve the social impairment of autism patients and plays a role by up-regulating the expression of MyT1L in the hippocampus.

This invention relates to the field of pharmaceutical analysis technology, and provides a method for detecting enantiomers in peramivir sodium chloride injection. The method employs high-performance liquid chromatography (HPLC), with the following chromatographic conditions: a column packed with α1-acidic glycoprotein-bonded silica gel; a mobile phase consisting of a mixture of 0.02 mol / L ammonium dihydrogen phosphate solution and 0.02 mol / L diammonium hydrogen phosphate solution at a volume ratio of 45:55 to 55:45; a detection wavelength of 205 nm; a flow rate of 0.25 to 0.35 mL / min; and a column temperature of 18 to 22 °C. Before detection, a test solution, a reference solution, and a system suitability solution are prepared, and each solution is accurately injected into the HPLC system. The chromatograms are recorded, and the enantiomer content is calculated. The advantages of this invention are: simple operation, no sodium chloride interference, and accurate quantitative detection of enantiomers in peramivir sodium chloride injection.

The utility model provides a push-and-pull tool for an injector, which belongs to the technical field of push-and-pull tools and comprises a mounting seat, a first power source component, a second power source component, an assembly part, a clamping part, a sliding part, a driving component and a bearing part. The first power source assembly is arranged on the mounting base and comprises a connecting piece. The second power source assembly is fixedly arranged on the connecting piece, and the second power source assembly is provided with a load sliding table. And the assembly part is fixedly connected with the load sliding table. And the clamping piece is fixedly connected with the assembly piece. The sliding part is in sliding connection with the assembly part. The driving assembly is used for driving the sliding part to slide. And the bearing piece is connected with the mounting seat. According to the push-and-pull tool for the injector, the problem that when a medical worker extracts sodium chloride injection from a PP bottle through the injector, a needle head on the injector may puncture the medical worker can be solved.

This invention discloses a water softening system, relating to the technical field of water softening systems. It includes a bottom support assembly, with a water softening component mounted on top. The top of the water softening component is connected to an evaporator via a pipe. The system, in conjunction with the water softening component, filter screen, and salt filter, performs preliminary filtration of the incoming raw water. Then, sodium chloride is injected into the catalyst injection chamber through the sodium chloride injection end. The presence of two convection devices at an angle increases the dissolved oxygen required during the delivery of the sodium chloride aqueous solution. Calcium ions are then adsorbed through a calcium ion adsorption alumina membrane. A resistor, connected to a controller and an internal power supply, electrically connects the system, causing an induction coil to rotate under the influence of a drive motor. This generates a magnetic field at the bottom of the water softening chamber, adsorbing calcium, sodium, and magnesium ions in the raw water, effectively improving the water softening efficiency.

The utility model discloses a device for detecting the content of a sodium chloride injection intermediate, and relates to the technical field of pharmacy. Comprising a detection cup, a Raman spectrum detector, a U-shaped pipe and a gas filtering device, an opening is formed in the lower portion of the detection cup, the opening is sealed through a cover plate, a liquid inlet pipe, a liquid outlet pipe and the Raman spectrum detector are installed on the cover plate, a Raman probe of the Raman spectrum detector upwards extends into the detection cup, and the U-shaped pipe is connected with the gas filtering device. A U-shaped pipe is further installed on the cover plate, one end of the U-shaped pipe extends to the upper portion in the detection cup, and the other end of the U-shaped pipe is located outside the detection cup and provided with a gas filtering device; the quantity of bubbles generated in the process that liquid enters the detection device can be reduced, the bubbles are prevented from being attached to the outer surface of a Raman probe of the Raman spectrum detector to influence the detection accuracy, meanwhile, the liquid inlet time is shortened, and the detection efficiency is improved.

The application relates to the field of biological medicine, in particular to a glycerol fructose sodium chloride injection and a preparation method thereof. The glycerol fructose sodium chloride injection contains 80-120 g of glycerol, 40-60 g of fructose, 7-11 g of sodium chloride, 0.6-2.0 g of lecithin, 0.1-0.4 g of organic acid and injection water per 1000 mL. The lecithin is dispersed in the injection water at 50-60 DEG C first, then the glycerol, the sodium chloride and the organic acid are added, the fructose is added after the system is cooled to below 40 DEG C, finally the volume is fixed and the pH is adjusted to 4.0-4.5, and the two-stage filtration and wet heat sterilization are carried out to obtain the glycerol fructose sodium chloride injection. The compound of the lecithin and the organic acid can significantly inhibit the generation of the fructose degradation product 5-hydroxymethyl furfural.

The invention discloses a hypertonic muscle injection for an immune wake-up therapy and a preparation method of the hypertonic muscle injection, and relates to the medical field, the injection is hypertonic glucose with the concentration of 15-25%, and is only composed of anhydrous dextrose and water for injection; the injection is used for intramuscular injection, anatomical local injection, traditional Chinese medicine acupoint injection and focus part injection based on a targeting principle, and intravenous injection is strictly prohibited; compared with the prior art, the invention has the beneficial effects that controllable micro-injury is caused by the hypertonic glucose or sodium chloride injection, the central immune system is awakened, lesions are automatically cleared by autoimmunity, various diseases can be treated at the same time, and the defect of single target spot is overcome; the preparation only consists of sugar / salt and water for injection, and has no toxic or side effect and no drug resistance; raw materials are easy to obtain, the process is simple, cost is extremely low, and patient burden is remarkably relieved; the medicine is simple and convenient to operate, wide in adaptation disease, capable of being combined with any existing therapy and extremely high in clinical value.

This invention relates to an injectable paclitaxel formulation designed to enhance solubility and stability. The formulation comprises paclitaxel at a concentration of 6 to 12 mg / mL, with Vitamin E Polyethylene Glycol Succinate (TPGS) serving as a surfactant and solubilizer in concentrations ranging from 300 mg / mL to 600 mg / mL. Polyethylene glycol 300 (PEG 300) acts as a stabilizer, and citric acid is included as a buffering agent, along with water for injection. The formulation is stable at room temperature for about 27 hours after dilution in infusion liquids such as 5% dextrose injection USP, 0.9% sodium chloride injection USP, 5% dextrose and 0.9% sodium chloride injection USP and 5% dextrose in Ringer's Injection solutions. The diluted formulation forms a nano micellar solution with micelles ranging from 10 to 100 nm in size, ensuring a stable and clear solution for intravenous administration of paclitaxel, thus improving safety and efficacy.

The invention discloses a liquid chromatography method for measuring oxalic acid in a calcium gluconate and sodium chloride injection. The method comprises the following steps: preparing a reference substance stock solution; preparing a reference solution; preparing a test solution; preparing a system applicability solution; measuring the system applicability solution and injecting the system applicability solution into a liquid chromatograph to obtain a system applicability solution chromatogram; after it is verified that the overall performance of the chromatographic system meets the requirements, the test solution and the reference solution are measured and injected into a liquid chromatograph, and chromatograms are recorded; obtaining the peak area of the oxalic acid in the test solution and the peak area of the oxalic acid in the reference solution from the chromatogram, and combining the marked concentration of calcium gluconate in the test solution, the weighing amount of the oxalic acid in the reference solution, the purity of the oxalic acid reference substance, the dilution ratio of the test solution and the dilution ratio of the reference solution; the percentage of the oxalic acid content is obtained through an oxalic acid content calculation formula. The method can be used for rapidly and accurately measuring the content of oxalic acid in the calcium gluconate and sodium chloride injection with high sensitivity.

The invention discloses a method for detecting nitrosamine impurities in a levofloxacin sodium chloride injection, and relates to the field of substance detection methods, the nitrosamine impurities comprise N-nitrosolevofloxacin and 1-methyl-4-nitrosopiperazine, the detection method adopts high performance liquid chromatography and mass spectrometry, and the content of the nitrosamine impurities in the levofloxacin sodium chloride injection can be detected. The high performance liquid chromatography comprises a gradient elution procedure; wherein a mobile phase of the high performance liquid chromatography comprises a mobile phase A and a mobile phase B; the mobile phase A comprises ammonium formate and formic acid; the mobile phase B comprises formic acid and acetonitrile. Through a high performance liquid chromatography-mass spectrometry technology, a water phase containing ammonium formate and formic acid and an acetonitrile organic phase containing formic acid form a mobile phase system for gradient elution; therefore, the purpose of establishing a special detection method for the N-nitrosolevofloxacin and the 1-methyl-4-nitrosopiperazine in the levofloxacin sodium chloride injection is achieved.