377 results about "Fluid exchange" patented technology

A catheter includes a sealed multi-lumen heat transfer extension designed to internally circulate a coolant, and thereby cool tissue or fluid surrounding the catheter. The heat transfer extension includes a tube having a distally positioned region that coils about the tube's longitudinal axis. The tube houses multiple lumens running longitudinally along the tube. These lumens include one or more supply lumens and one or more return lumens. A distal fluid exchange reservoir resides at the tube's tip, for the purpose of redirecting fluid from the supply lumen(s) to the return lumen(s). The heat transfer extension may include a shape memory structure causing the heat transfer extension to vary its shape according to temperature. Namely, the extension assumes a coiled shape under predetermined shape-active temperatures, and it assumes a non-coiled shape under other predetermined shape-relaxed temperatures. The catheter also includes an interface having supply and return lines to provide coolant to the heat transfer extension, and remove coolant returning therefrom. To connect the supply/return lines with the supply/return lumens, the invention may include a fluid transfer housing. Optionally, one or more of the lumens may be configured as flow-through lumens to exchange fluids with the patient.

A multi-lumen catheter and method for inserting same in a patient is disclosed. The catheter includes an elongated, central, multi-lumen tube portion having a proximal end and a distal end. The central tube portion has a substantially cylindrical outer shape and is internally segmented into a plurality of lumens. A distal branch portion includes a plurality of single-lumen distal extension tubes. A proximal branch portion includes a plurality of single-lumen proximal extension tubes. Each proximal extension tube has a distal first end and a proximal second end. The distal first end of each proximal extension tube is connected to the proximal end of the central tube portion such that the single lumen of each distal extension tube is in fluid communication with one of the plurality of lumens of the central tube portion. Each lumen of the central tube portion and the lumens of the distal and proximal extension tubes in fluid communication therewith define a flow path through the catheter. Selectively attachable hub connectors are provided for selective attachment to the distal extension tubes and connection of the catheter to a fluid exchange device.

A flow management system for extracorporeal blood treatment application helps to ensure proper balance of incoming and outgoing fluids by precise balancing of relatively small balance chambers. The invention employs combinations of features that help to ensure accuracy including underfilling of the waste flow side of a fixed volume chamber and mechanical connections to synchronize valves and pumps.

Methods and devices for exchanging therapeutic agents, such as cells, from one liquid medium to another liquid medium are provided. Aspects of embodiments of the methods include transferring a therapeutic agent from a first medium, such as a freezing, storage or shipping buffer, into a second medium, such as a sterile physiologically compatible buffer. In certain aspects, the transfer of the therapeutic agent from a first medium to a second medium involves the use of acoustic-focusing, or acoustophoresis. Embodiments of the subject methods may facilitate the transfer of a therapeutic agent from a storage medium to an infusion medium, and in certain embodiments include administering the therapeutic agent contained in the infusion medium to the subject. Also provided by the present disclosure are devices for practicing the subject methods.

A sample chamber is formed by a housing sealed against a microscope slide. The housing has fluid ports, including a well formed over at least one port. In a rinse station, rinse solution is drawn from a reservoir through the chamber to a waste reservoir. At a fill station, an aliquot of reagent already placed in the well is driven into the chamber. The reagent may be driven into the chamber by first drawing a vacuum on the chamber through the aliquot of reagent and then releasing the reagent to be drawn into the chamber by the vacuum.

A fluid exchanger for servicing the fluid circuits of vehicular power steering systems and other fluid circulating or hydraulic circuits. The fluid exchanger uses a float operated fluid control valve to harness fluid pressure provided by a pump of an accessed hydraulic circuit. The fluid control valve uses both negative and positive pressure of the circuit's pump to control fluid flow patterns. The float and fluid control valve are matched to be either mechanical/hydraulic or electrical/hydraulic in design. If the exchanger is provided with a mechanically operated fluid control valve, a mechanical float is provided in the exchanger's fresh fluid reservoir and is directly connected to the valve slide of the fluid control valve. If the exchanger is provided with an electric solenoid operated fluid control valve, a float operated electrical switch is provided in the exchanger's fresh fluid reservoir and is wired to control the solenoid of the valve.

Devices and methods are provided for more efficiently performing electrophoresis and electroblotting. A sandwich structure includes an electrophoresis gel affixed to a blotting membrane. A gel casting and/or running frame is used to hold the sandwich. A method and composition that allows separation of the gel and membrane after performing a combined electrophoresis and electroblotting operation so as to allow further operations to be performed individually upon the membrane, gel or both. A uniform electrophoretic field may be created by surrounding the sandwich structure using an insulating fluid; the insulating fluid is then swapped for a conducting fluid to allow application of an electroblotting field. An apparatus automatically manages fluid exchange and actuation of electrophoresis and electroblotting electrodes. A plurality of parallel cavities may be used to hold multiple gels or gel membrane sandwiches.

The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the eye and orbit, this device can be used in hypothermia or hyperthermia applications, the control of intraocular pressure (IOP), and the application of treatment modalities. Methods of using the device in treating patients suffering from central retinal artery occlusion, anterior optic nerve disease, pathology of the choroid and retina including the macula, inflammation of the eye including the vitreous and anterior segment, glaucoma, inflammation and/or infections of the anterior and/or posterior segment of the eye, treatment before/during/after surgery of the eye, and the application of treatment modalities through a semi-permeable membrane are described.

The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the eye, eyelid and orbit, this device can be used in hypothermia or hyperthermia applications, the control of intraocular pressure (IOP), and the application of treatment modalities. Methods of using the device in treating patients suffering from central retinal artery occlusion, anterior optic nerve disease, pathology of the choroid and retina including the macula, inflammation of the eye including the vitreous and anterior segment, glaucoma, inflammation and/or infections of the anterior and/or posterior segment of the eye, treatment before/during/after surgery of the eye, and the application of treatment modalities including iontophoresis through a semi-permeable membrane are described.

An improved instrument for removing subretinal fluid and performing fluid exchanges in vitreoretinal surgery is disclosed. The instrument includes a cannula with a curved distal portion and a side port on the curved distal portion for aspirating subretinal fluid. The instrument also includes a second port for aspirating a second fluid from the vitreous cavity during a fluid exchange.

Particular embodiments disclosed herein relate to methods, compositions, and systems relating generally to heating, ventilation, and air conditioning (HVAC) systems, and more specifically, to HVAC systems that transfer sensible and/or latent energy between air streams, humidify and/or dehumidify air streams. In certain embodiments, a polymeric membrane is utilized for fluid exchange, with or without an additional support. Certain embodiments allow for individual regulation of air temperature and humidity.

Fluidic lens devices, and systems employing such lens devices, along with methods of fabricating and operating such lens devices, are disclosed. Certain of the disclosed structures permit fluidic lens devices to operate without valves that control fluid exchange between fluidic lenses and reservoirs. Also disclosed are fluidic lens devices that comprise a fluidic lens but no reservoir. Additional disclosed structures and methods permit fluidic lens devices to perform zoom and focus functions.

The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the central nervous system (CNS), this device can be used in hypothermia or hyperthermia applications, the exchange of cerebral spinal fluid (CSF), the application of treatment modalities, and the insertion of a ventriculostomy or ventriculostomy-like unit. When applied to spinal cord applications, this device can provide temperature control and a method for application of treatment modalities by using a venting device placed in the space surrounding the spinal cord, a device with similar instrumentation to measure temperature and pressure. A device for ultrasound localization of the CNS device is described. A device for a fiber optic endoscope for visualization and localization is also described. Method of using the devices in treating patients suffering from cardiac arrest, circulatory arrest, exsanguination, head or neck trauma, strokes, tumors and other intracranial diseases are disclosed. In the case of hypothermia treatment of the brain, rapid cooling using principles of convection and conduction will be applied to the lateral ventricle and subarachnoid and/or subdural space simultaneously where the neurons are located in close proximity.

Exchanger devices include a plurality of fixed exchange ducts and a rotating valve assembly for directing flow to and from the plurality of exchange ducts. Methods of exchanging pressure between fluid streams may include directing fluids through an exchange device and pressurizing a fluid in the plurality of exchange ducts of the exchanger device.

The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the eye, eyelid and orbit, this device can be used in hypothermia or hyperthermia applications, the control of intraocular pressure (IOP), and the application of treatment modalities. Methods of using the device in treating patients suffering from central retinal artery occlusion, anterior optic nerve disease, pathology of the choroid and retina including the macula, inflammation of the eye including the vitreous and anterior segment, glaucoma, inflammation and/or infections of the anterior and/or posterior segment of the eye, treatment before/during/after surgery of the eye, and the application of treatment modalities including iontophoresis through a semi-permeable membrane are described.

The present invention provides a fluid exchange cell culture technique and tissue repair cells (TRCs) made by these methods, as well as methods using these cells. The method includes a new wash step which increases the tissue repair properties of the TRCs of the invention. This wash step allows for the production of TRC populations with greater tissue repair and anti-inflammatory capabilities. Embodiments of the present invention include a post-culture process for cultured cells that preferably includes the steps of: a wash process for removing unwanted residual culture components, a volume reduction process, and a harvesting process to remove cultured cells. Preferably, all these steps are performed within a aseptically closed cell culture chamber by implementing a separation method that minimizes mechanical disruption of the cells and is simple to automate. The harvested cells may then be concentrated to a final volume for the intended use. In such embodiments, the final composition is a substantially purified and concentrated cell mixture suspended in a physiologic solution suitable for immediate use in humans without further washing, volume reduction, or processing. Embodiments are also applicable to harvesting (and/or washing) particles within a liquid or solution within a chamber.

A hydrodynamic clutch device includes a clutch housing connected to a drive, a pump wheel connected to the clutch housing, and a turbine wheel connected to a takeoff, the turbine wheel and the pump wheel forming a hydrodynamic circuit. A bridging clutch which is essentially surrounded by the hydrodynamic circuit includes a piston and at least one friction surface which can be acted on by the piston to connect the drive to the takeoff independently of the hydrodynamic circuit, the piston having one surface facing the hydrodynamic circuit and an opposite surface facing a pressure space. A pressure circuit includes a first pressure medium line to supply the hydrodynamic circuit with clutch fluid and a second pressure medium line to supply the pressure space with clutch fluid. A seal at least reduces the exchange of fluid between the hydrodynamic circuit and the pressure space, and a throttle allows a defined exchange of fluid between the hydrodynamic circuit and the pressure space.

A catheter system that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The system has devices that control the infused liquid's pressure changes accordingly to the aspirated liquid's pressure changes, in order to allow accurate and safe fluid exchange flow control and create changes of pressures at the catheter's tip that do not allow the catheter's blockage.

The present invention is directed to, in part, modules that allow for the exchange of a fluid such as a liquid or gas to and/or from a medium or surface and systems and methods comprising same. In one embodiment, there is provided an apparatus for directing the flow of a fluid passing through a medium, the apparatus comprising a top having a plurality of perforations and a base that is positioned adjacent and substantially parallel to the top, thereby defining a cavity for passage of fluid therein. The top comprises a plurality of integrated supports extending from the bottom surface of the top, the integrated supports maintaining the height of the cavity and being sufficient in number, size, and physical properties as to permit the top to support the weight of the medium and activity above the medium. A sealing strip can be installed within the cavities of the modules to contain or direct fluid within the system.

An ORC binary cycle geothermal plant, including at least one ORC closed-cycle system and a geothermal system. The geothermal system includes at least one intake line of a geothermal fluid connected to at least one geothermal production well, wherein the fluid includes non-condensable gases; one interface line connected to the intake line, coupled to the ORC system in an interface zone, wherein the fluid exchanges heat with the organic working fluid; one reinjection line connected to the interface line and to at least one geothermal reinjection well. Further at least one separator device configured to separate at least the gases from the fluid; one expander connected to an outlet of the gases by the separator device; and one auxiliary generator connected to the expander. The expander is for interfacing with the system to receive and expand at least the gases after they have exchanged heat with the organic working fluid.

A method for modelling flows in a fractured medium crossed by a network of fluid conducting objects of definite geometry but not homogenizable on the scale of each grid cell of the model (large fractures, sub-seismic faults for example, very permeable sedimentary layers, etc.) which has an application in the evaluation of hydrocarbon reservoirs is disclosed. The method allows simulation fluid of flows in a fractured porous geologic medium of known structure that is discretized with a grid and modelled by considering that each elementary volume of the fractured geologic medium is an equivalent fracture medium and matrix medium on the scale of each cell between which fluid exchanges are determined. The method determines exchanges between the matrix medium and the fracture medium, and modeles the transmissivities of the various cells crossed by each conducting object, so that the resulting transmissivity corresponds to the direct transmissivity along each conducting object. Explicit modelling of these objects, which is prohibitive on the scale of a field because of the very large number of cells involved and of the numerical constraints, is therefore unnecessary.

The invention provides a heat pipe which comprises an evaporation header, a condensation header, ascending pipes and a backflow pipe. The ascending pipes and the evaporation header communicate with the condensation header. The evaporation header is located at the lower portion, and the condensation header is located at the upper portion. Fluid absorbs heat and is evaporated in the evaporation header and then enters the condensation header from the ascending pipes. The fluid exchanges heat in the condensation header and is then condensed, and the condensed fluid goes back to the evaporation header through the backflow pipe. Flow stabilizing devices are arranged in the ascending pipes, and the multiple flow stabilizing devices are arranged in the same ascending pipe. The length of the flow stabilizing devices is increased gradually in the height direction of the ascending pipes. By means of the heat pipe, due to the length changing of the flow stabilizing devices, when gas-liquid two phase flow in the ascending pipes, heat transfer is strengthened, meanwhile, vibration of the ascending pipes is weakened, and the noise level is lowered.