38 results about "Vitreous cavity" patented technology

The invention belongs to the field of biological medicine, and particularly relates to application of caffeic acid phenethyl ester to preparation of medicine for treating myopia and a medicine composition of the caffeic acid phenethyl ester. It is found for the first time that phenethyl caffeate can promote collagen synthesis of sclera fibroblasts directly related to myopia, inhibit and slow down ocular axis extension and vitreous cavity length increase of a myopia individual, and can increase sclera thickness, so that the effect of delaying and treating myopia is achieved; the invention provides a new choice for clinically treating myopia, and has a good application prospect.

In certain embodiments, an ophthalmic system is provided. The ophthalmic system includes a low power laser source configured to generate a low power laser beam, wherein the low power laser source has a power of between 5 milliwatts (mW) and 20 mW, and a first illumination device configured to transmit the low power laser beam into a vitreous cavity of an eye. The ophthalmic system further includes a red-green-blue (RGB) light-emitting diode (LED) light source configured to generate a RGB light, and a second illumination device configured to transmit the RGB light into the vitreous cavity of the eye.

The utility model discloses a negative pressure suction device for taking a dislocated intraocular lens. The negative pressure suction device mainly comprises a suction catheter, a catheter seat, a butt joint seat, an extension tube, a negative pressure generation device and a negative pressure control device, wherein the combined structure of the suction catheter and the catheter seat can be realized by directly adopting a 22G venous indwelling needle catheter, the combined structure of the suction catheter and the catheter seat is connected to the extension tube through the butt joint seat, the combined structure of the negative pressure generation device and the negative pressure control device can be realized by directly adopting an ultrasonic emulsification and vitreous body cutting machine and a matched pedal controller, and the extension tube is in butt joint with a negative pressure port of the extension tube. The negative pressure is adjusted through the pedal controller, the intraocular lens dislocated to the vitreous cavity is attracted to the pupil area, and damage to the retina in an operation is avoided. The device has the advantages of simplicity and convenience in operation, controllable negative pressure, small trauma and the like, is suitable for minimally invasive extraction or reduction of a dislocated intraocular lens in clinic, and is wide in adaptability.

The assembled intraocular tweezers comprise an outer cylinder, a lens bin and a lens clamping assembly, the lens bin is fixed to the front end face of the outer cylinder, the front end of the lens bin can be inserted into the cornea, and the lens clamping assembly comprises a wall cylinder slidably connected to the interior of the outer cylinder; a guide sliding seat slidably connected into the outer cylinder is arranged in front of the wall cylinder, a first spring is arranged between the guide sliding seat and the front wall of the outer cylinder, a fixing plate is arranged at the rear end of the interior of the wall cylinder, forceps rods are fixed to the front end of the fixing plate, and the forceps rods penetrate through the guide sliding seat and the front wall of the outer cylinder to extend into the crystal bin. And two elastic forceps heads are arranged at one end, extending into the crystal bin, of the forceps rod. Compared with the prior art, the surgical incision is small (the main incision does not need to be expanded), the anterior chamber operation is less, the intraocular lens is easy to take out, and the corneal endothelium injury is less; the method is also suitable for an intraocular lens falling into a vitreous cavity.

The application discloses a diopter-adjustable and real-time retina imaging detection simulation eye, comprising: an emulated cornea, an emulated lens and an adjustable vitreous structure arranged in sequence along an optical axis; the adjustable vitreous structure comprises: a vitreous cavity filled with an emulated vitreous, a curved retina arranged at the end of the vitreous cavity, and a micrometer adjustment system for driving the curved retina to move forward and backward along the optical axis; the foveal region of the curved retina is integrated with an attenuation module and an imaging module, which are used for collecting a light spot image on the foveal region in real time; the simulation eye further comprises an analysis module electrically connected with the imaging module, and the analysis module is configured to process the collected light spot image to extract optical parameters on the curved retina.

A small gauge surgical instrument assembly is shown with advantages such as diminished “play” at the tip. A surgical instrument assembly is also shown with support along a length of the instrument that can be selected by the surgeon. In particular, very small and flexible instruments for vitreous surgery are shown with selectable stiffness, thus providing control as well as access to all parts of the vitreous cavity. Embodiments as shown are safer, and increase the variety of cases for which these instruments can be used.

The invention discloses an expandable vitreous cavity crystal shedding blocking device for cataract surgery, relates to the technical field of cataract surgery auxiliary instruments, and provides the following scheme that the expandable vitreous cavity crystal shedding blocking device comprises a blocking net injection mechanism, and the front end of the blocking net injection mechanism is connected with a crystalline lens blocking net; and the barrier net injection mechanism comprises an outer sleeve. A spiral transmission structure of the screwing pipe and the outer sleeve is combined with a linkage mechanism of the transmission rod and the traction block, control over the crystalline lens blocking net by the medical steel wire is achieved, the medical-grade polycarbonate oval outer ring and the medical-grade polycarbonate oval inner ring can be unfolded or folded according to needs, a stable bearing concave face can be formed in an operation to prevent a crystalline lens from falling off, and the use effect of the medical-grade polycarbonate oval outer ring and the medical-grade polycarbonate oval inner ring is improved. In addition, numerical value marks of the observation opening provide visual screwing depth reference for doctors, and the postoperative infection risk is reduced by combining tight sealing of liquid in the eyes through the sealing ring.

An ophthalmic assembly includes a frame, flange, and light emitter. The frame supports an optical lens. A first end of the flange is connected to the frame. A second end of the flange rests on a pars plana region of the sclera of a patient's eye. The light emitter is connected to the flange proximate the second end to direct light into a vitreous cavity of the patient's eye. This occurs through the sclera at the pars plana region and uniformly illuminates the vitreous. A transscleral illumination system includes the ophthalmic assembly and a processor in communication with the light emitter. A setting of the light emitter may be controllable via the processor, e.g., in response to a user input signal.

The invention relates to an application of an rAAV-mediated PEDF gene in treatment of uveitis, specifically, a recombinant adeno-associated virus is used as a gene delivery carrier, the PEDF gene is efficiently introduced into a vitreous cavity, and continuous and stable expression of PEDF in eyes is realized, so that the PEDF is used for treating autoimmune uveitis, and a new thought is provided for development and treatment of new clinical drugs for uveitis.

This invention discloses a spring-loaded intraocular syringe based on intraocular pressure feedback, belonging to the field of medical devices. The core improvement of this device lies in the integration of an integrated spring mechanism at the syringe outlet interface. Its main structure is a hollow cylindrical structure forming a three-way connection with the syringe outlet interface. A sealing septum divides the inner cavity of the main structure into a non-communicating medication chamber and a spring chamber. During injection, the intraocular pressure is transmitted to the sealing septum through the medication. When the pressure exceeds the spring's preset preload, the spring is compressed, causing the sealing septum to displace. When this displacement reaches a preset safe intraocular pressure threshold, it triggers a visually intuitive stop signal, objectively and accurately prompting the operator to stop the injection. This invention achieves automatic matching control of the injection volume and intraocular pressure through a mechanical pressure feedback mechanism, reducing reliance on operator experience and improving the safety and precision of surgical procedures, making it particularly suitable for primary healthcare settings.

An ophthalmic assembly includes a frame, a flange, and a light emitter. The frame supports the optical lens. A first end of the flange is connected to the frame. The second end of the flange rests on a ciliary body flat region of the sclera of the patient's eye. A light emitter is connected to the flange proximate the second end to direct light into a vitreous cavity of the patient's eye. Light passes through the sclera at the flat region of the ciliary body, uniformly illuminating the vitreous body. A transscleral illumination system includes the ophthalmic assembly and a processor in communication with the light emitter. The setting of the light emitter may be controlled via a processor, for example in response to a user input signal.

The utility model provides a pair of microscopic forceps with an injection positioning function, which comprises a forceps handle, the forceps handle is connected with a first grab handle and a second grab handle, the first grab handle and the second grab handle are connected with a connecting block, and the connecting block is connected with a forceps tip; a positioning measuring column is arranged on the side wall of the first grab handle, a limiting block is arranged on the side wall of the second grab handle, the through hole extends to the limiting block, a containing groove is formed in the limiting block, one end of the positioning measuring column is connected into the containing groove in a sliding mode, the second grab handle is connected with a fixing assembly, and when the positioning measuring column is fixed, the tip ends of the two tweezers are parallel to each other. By means of the structure, the instrument can have the distance measuring function and the tweezers function, and operation is simplified. During measurement, the positioning measuring column is fixed, and the tip of one tweezers is tangent to the edge of the cornea, so that the micro tweezers can accurately position the position of an injection point during vitreous cavity injection. And after the positioning measuring column is loosened, the two tweezers tips can be folded, so that the microscopic tweezers have the tweezers function.

The invention discloses a vitreous cavity medicine injection center scheduling method and system based on hybrid reinforcement learning and a storage medium. The method mainly solves the problems of slow convergence, low exploration efficiency and the like when a traditional scheduling method is used for processing a high-dimensional state space, sparse reward signals and multi-target conflicts. The method has the beneficial effects that the scheduling efficiency is remarkably improved: in a simulation environment, the average waiting time of patients can be shortened by more than 20%, and the treatment room turnover rate is improved by more than 15%; the system is high in adaptability: through a hybrid reinforcement learning architecture, patient flow change and resource state fluctuation can be dynamically responded, and long-term steady-state optimization is realized; multi-objective collaborative optimization: efficiency, fairness and medical safety are effectively balanced through multi-objective reward function design and constraint embedding; and the system provides a decision explanation mechanism, so that the sense of trust and the use intention of medical staff to the intelligent scheduling scheme are enhanced.

The present application relates to a kind of lens puncture fixing devices, lens puncture fixing device includes outer tube unit, inner core unit, claw unit, inner core control unit and claw control unit, or, lens puncture fixing device includes outer tube unit, inner core unit, claw unit and claw control unit, or, lens puncture fixing device includes outer tube unit, inner core unit, claw unit and outer tube control unit.Its advantages are, by the relative motion of outer tube unit and inner core unit, realize puncture function, by the relative motion of claw unit and inner core unit, realize clamping fixed function, dislocation lens is fixed in pupil area, reduce the excessive cortex or nuclear fragment falling into vitreous cavity in the process of resection by vitrectomy head;Puncture function and clamping fixed function are integrated and arranged, realize two-stage fixed mode using one instrument, reduce operation difficulty.

The invention discloses application of oroxylum indicum total flavonoids in preparation of a medicine for treating uveitis. Experiments prove that the eye drops taking the oroxylum indicum total flavonoids or the oroxylin A as the active ingredient can reduce the uveitis eye inflammation and retina injury degree and reduce the infiltration quantity of inflammatory cells. The oroxylum indicum general flavone is taken as an oral medicine, so that inflammatory infiltration cells of a vitreous cavity and an iris-ciliary body can be reduced, bleeding symptoms can be effectively improved, hyperplasia of iris-ciliary body tissues can be inhibited, and infiltration of leukocytes of aqueous humor in mouse eyes can be effectively inhibited.

An illumination system includes a light source configured to generate light having a first optical property and a transscleral illumination device configured to transmit light having the first optical property across a sclera and into a vitreous cavity of an eye. A sensor is configured to detect light in the vitreous cavity of the eye as having a second optical property. The sensor generates a first signal indicative of the second optical property. One or more processors receive the first signal and cause the light source to generate light having a third optical property based on a the first signal. The sensor detects light in the vitreous cavity of the eye as having an optical property that is at least within a threshold of the first optical property. The sensor generates a second signal indicative of the first optical property.

The invention provides an injection gas pressure maintaining injector in a vitreous cavity gas injection operation, and relates to the technical field of ophthalmologic operation instruments, the injection gas pressure maintaining injector comprises a main body, a first chamber and a second chamber which are separated by a partition plate are arranged in the main body, and an elastic sealing plug is arranged on the partition plate. During air intake, the piston is pulled backwards, and the sealing plug blocks the vent hole; during air outlet, the air inlet is closed, the piston is pushed forwards, and the sealing plug is pressed to deform to conduct airflow. After pushing injection is finished and pressure is removed, the sealing plug is automatically reset and locked, and gas backflow is prevented. The one-way valve function is achieved through a pure mechanical structure by means of the air pressure difference, thrust does not need to be kept all the time, the problems of gas backflow and retina restoration failure caused by the fact that a common injector cannot achieve automatic pressure maintaining are thoroughly solved, and the success rate of an operation can be effectively guaranteed.

The invention discloses an eye trauma vitreous cavity foreign matter grappling hook, relates to the technical field of ophthalmology department grappling hook instruments, and provides the following scheme that the eye trauma vitreous cavity foreign matter grappling hook comprises a grappling hook traction piece, a grappling hook replacement connector is connected to the front end of the grappling hook traction piece in a clamped mode, and a grappling hook expansion and contraction control pipe fitting is fixedly connected to the front end face of the grappling hook replacement connector. The flexible polycarbonate claws are adopted as the claw hook pieces, the anti-slip lines are arranged on the inner sides, the memory metal wires are implanted into the claw hook pieces, the friction force between the claw hook pieces and foreign matter is increased, the outward expansion posture is kept, and the problems that at the present stage, foreign matter grabbing forceps are small and prone to slipping are effectively solved. For circular hard foreign matters, the flexible polycarbonate claws are controlled to retract and release through deformation of the fan-shaped silica gel sheets, so that the circular hard foreign matters can be stably clamped, and the grabbing difficulty is overcome. The design of a claw hook traction piece facilitates operation of a doctor, and accurate control is achieved through a push-pull rod and a thumb hook ring. A grab hook replacement connector and a rear pressing end cover connected through magnetic attraction are convenient to replace different grab hook expansion and contraction control pipe fittings and take out foreign matters, and operation efficiency and safety are improved.

The present application belongs to the field of medical device technology, and aims to solve the problem of intraoperative retinal fixation. Specifically, it relates to a retinal depressor for fixing the retina during vitreous surgery, which is generally used in subretinal surgery, and comprises a first component, a second component, and a third component connected in sequence; the second component is arranged at a first preset angle with the first component to form a fixing surface for the retina; the third component is used to fix a traction line; the longitudinal axis of the third component is arranged at a second preset angle with the fixing surface; when placed in the vitreous cavity, due to the effect of gravity, the depressor as a whole will sink to the posterior pole of the entire eyeball, the second component and the first component form a suppressing surface for the retina, and the tilted third component does not interfere with the retina, and the fixed traction line facilitates the adjustment of the delivery position and the suppressing position of the first component and the second component, so as to complete the suppression of the preset position of the retina, with high precision and strong flexibility.

The invention relates to the technical field of biological medicine, in particular to sophocarpine and application of sophocarpine in inhibiting formation of subretinal fibrosis, and the sophocarpine comprises the following steps: selecting 7-week-old male C57BL / 6J mice, adaptively feeding the mice for 1 week, and performing 12-hour illumination / 12-hour dark circulation at the environment temperature of 22-25 DEG C; the method comprises the following steps of: performing intraperitoneal injection of thiobarbital sodium on a C57 mouse fed for 1 week for anesthesia, realizing muscle relaxation by using hypnotic, and anesthetizing ocular surface by using 0.4% tetracaine and 0.5% tropicamide mydriasis; a mouse is randomly divided into a control eye and an experiment eye, and 1 microliter of PBS containing 1.5% of DMSO is injected into the control eye to serve as a carrier for control. The invention finds that injection of sophocarpine in vitreous cavity can inhibit RPE cell epithelial-mesenchymal transition, can be used for preventing or treating age-related macular degeneration subretinal fibrosis, may become a new medicine for treating subretinal fibrosis, has important value for inhibiting EMT of RPE cells, can also inhibit EMT of other cells, and can be used for preventing or treating age-related macular degeneration subretinal fibrosis and treating age-related macular degeneration subretinal fibrosis. Therefore, the method has potential application value on diseases caused by cell EMT.

The application provides an intraocular vitreous cavity foreign body optical fiber net bag, and relates to the technical field of medical devices, which comprises an outer sheath, a positioning block fixedly connected to one side of the outer sheath, a collecting assembly arranged on one side of the outer sheath, the collecting assembly comprising a shaping wire a, an arc-shaped shaping wire a, a shaping wire b, an arc-shaped shaping wire b and a net bag, and an optical fiber probe, and a pulling hole is formed in the inner part of the outer sheath. The foreign body optical fiber net bag can realize automatic tightening of the net bag opening through the arrangement of the collecting assembly, ensure the stability of foreign body capture, realize a two-handed cooperation mode of left-hand holding of the net bag and right-hand holding of a vitreous cutting head, improve the safety of surgery, and realize locking and quick release of the position of the net bag through the arrangement of a limiting assembly, cooperate with the elastic reset function of a small spring, and enhance the convenience and reliability of the operation of the device.

The invention relates to the technical field of biology, in particular to a PEDF mutant targeting VEGFR2 (vascular endothelial growth factor receptor 2) and application of the PEDF mutant in fundus neovascularization diseases. The sequence of the PEDF mutant of the targeted VEGFR2 is as shown in SEQ ID NO: 1. The invention provides a single injection recombinant adeno-associated virus (rAAV) gene therapy, which is used for treating VEGF (vascular endothelial growth factor) related eye diseases. The therapy prevents neovascularization by inducing expression of a mutant pigment epithelium-derived factor (PEDF). The method comprises the following steps: firstly, establishing two animal models of fundus neovascularization diseases, namely an extremely low density lipoprotein receptor gene knockout (Vldlr <- / ->) mouse model and an oxygen-induced ischemic retinopathy (OIR) mouse model; subsequently, anti-angiogenesis factors are injected into a vitreous cavity, and the result shows that clinically remarkable vasculopathy is almost completely inhibited in the established mouse fundus neovascularization model.

The invention relates to a lens puncture fixing device which comprises an outer tube unit, an inner core unit, a claw unit, an inner core control unit and a claw control unit, or the lens puncture fixing device comprises the outer tube unit, the inner core unit, the claw unit and the claw control unit, or the outer tube unit, the inner core unit, the claw unit and the claw control unit. The body puncture fixing device comprises an outer tube unit, an inner core unit, a claw unit and an outer tube control unit. The intraocular lens puncture device has the advantages that the puncture function is achieved through relative movement of the outer tube unit and the inner core unit, the clamping and fixing function is achieved through relative movement of the claw unit and the inner core unit, a dislocated crystalline lens is fixed to a pupil area, and the situation that excessive cortex or nucleus fragments fall into a vitreous cavity in the excision process of a vitreous head is reduced; the puncture function and the clamping and fixing function are integrated, a double-stage fixing mode is achieved through one instrument, and the operation difficulty is lowered.

An illumination system includes a light source configured to generate light having a first optical property and a transscleral illumination device configured to transmit light having the first optical property across a sclera and into a vitreous cavity of an eye. A sensor is configured to detect light in the vitreous cavity of the eye as having a second optical property. The sensor generates a first signal indicative of the second optical property. One or more processors receive the first signal and cause the light source to generate light having a third optical property based on a the first signal. The sensor detects light in the vitreous cavity of the eye as having an optical property that is at least within a threshold of the first optical property. The sensor generates a second signal indicative of the first optical property.

The utility model discloses a syringe device for animal vitreous cavity dosing, which belongs to the technical field of medical instruments, and comprises a holding cylinder with a U-shaped section, a medicine cylinder is connected in the holding cylinder, one end of the medicine cylinder is connected with a syringe needle, the syringe needle extends out of one end of the holding cylinder, and the other end of the holding cylinder is connected with the syringe needle. The other end of the holding cylinder penetrates through the two side wings of the holding cylinder to be rotationally connected with a guide rod, the guide rod is connected with one end of a pressing plate, and a pushing rod is slidably connected into the medicine cylinder. According to the injector device for animal vitreous cavity drug administration, by arranging the push rod, the guide rod, the pressing plate, the positioning rod, the auxiliary plate, the fixing disc and the torsional spring, through cooperation of the pressing plate, the auxiliary plate and the torsional spring, the injector device can conduct drug injection operation through one hand, and the other hand can support an animal; the flexibility of the injector device is improved, and when the pressing plate is loosened, the pushing rod can be reset through the torsional spring.

A shunt 200 for treating glaucoma in a patient during and / or after vitreoretinal surgery involving the use of a tamponading agent comprising a gas or oil bubble 50. The shunt includes a tubular body 12 having a proximal end 14 which is implantable in the vitreous cavity C of a patient and a distal end which is implantable in the subarachnoid space of the patient. The tubular body defines a lumen 18 extending between the distal and proximal ends. The shunt includes an occlusion body 32 defining a number of micro-passages 34 inflow communication with the lumen 18. The micro-passages are configured in terms of their size and number to provide sufficient surface tension and viscosity resistance in order to prevent the tamponading agent from passing through the micro-passages into the lumen, yet allow sufficient aqueous fluid from the vitreous cavity to travel along the micro-passages into the lumen 18 in order to regulate intraocular pressure.

The present invention discloses the use of recombinant fibrillin-2 protein in the preparation of products for preventing or treating fibrillin-2 deficiency eye diseases. The present invention is the first to construct a method for a mouse model of FBN2 gene-deficient eye diseases by intravitreal injection of an FBN2 gene interference vector AAV, and is the first to discover that intravitreal injection of FBN2 recombinant protein has a therapeutic effect on FBN2 gene-deficient eye diseases. The research of the present invention further proves a series of pathological and physiological changes caused by FBN2 gene deficiency in the development of ocular tissue retinopathy and myopia, and that intravitreal injection of exogenous FBN2 recombinant protein can make up for the problem of endogenous FBN2 deficiency in the FBN2 gene-deficient eye disease model, thereby achieving the effect of treating the disease, providing a new method for one-step targeted gene intervention research and indicating the research direction.

The invention relates to a lens puncture fixing device. The lens puncture fixing device comprises an outer tube unit, an inner core unit, a claw unit and an outer tube control unit. The intraocular lens puncture device has the advantages that the puncture function is achieved through relative movement of the outer tube unit and the inner core unit, the clamping and fixing function is achieved through relative movement of the claw unit and the inner core unit, a dislocated crystalline lens is fixed to a pupil area, and the situation that excessive cortex or nucleus fragments fall into a vitreous cavity in the excision process of a vitreous head is reduced; the puncture function and the clamping and fixing function are integrated, a double-stage fixing mode is achieved through one instrument, and the operation difficulty is lowered.

The invention provides an ophthalmic preparation and application thereof in slowing down myopia progression, the ophthalmic preparation is brimonidine, and it is found and proved for the first time that intravitreal injection of brimonidine can delay growth of an ocular axis so as to effectively slow down the myopia progression. Due to the fact that brimonidine is injected into the vitreous cavity, growth of an ocular axis can be delayed, and the diopter of eyeballs is improved. Meanwhile, under the action of the medicine, the intraocular pressure is also remarkably reduced. The ophthalmic preparation can effectively slow down the progression of myopia, has a potential effect of delaying the progression of the aging eye course, and has a very good clinical application prospect.

An ophthalmic assembly includes a frame, flange, and light emitter. The frame supports an optical lens. A first end of the flange is connected to the frame. A second end of the flange rests on a pars plana region of the sclera of a patient's eye. The light emitter is connected to the flange proximate the second end to direct light into a vitreous cavity of the patient's eye. This occurs through the sclera at the pars plana region and uniformly illuminates the vitreous. A transscleral illumination system includes the ophthalmic assembly and a processor in communication with the light emitter. A setting of the light emitter may be controllable via the processor, e.g., in response to a user input signal.