Drug-carrying type artificial lens capable of being opened by laser

A kind of intraocular lens, portable technology, applied in the direction of intraocular lens, drug device, eye implant, etc., can solve the problems of uncontrollable release time, slow release of drug, easy to cause complications, etc., to avoid side effects, reduce Effects of side effects and avoidance of complications

Inactive Publication Date: 2013-06-26
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the technical problems that the intraocular lens drug sustained release structure releases the drug slowly for a long time in the...

Method used

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  • Drug-carrying type artificial lens capable of being opened by laser
  • Drug-carrying type artificial lens capable of being opened by laser
  • Drug-carrying type artificial lens capable of being opened by laser

Examples

Experimental program
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Embodiment 1

[0016] see figure 1 and figure 2 As shown, the laser-openable drug-carrying intraocular lens includes an intraocular lens main body 1, and the intraocular lens is a standard soft foldable intraocular lens, such as hydrogel or silicone gel material, or other materials such as acrylate, etc. On the peripheral surface of the intraocular lens main body 1, there are a plurality of drug storage holes 2 which are respectively kept at predetermined intervals. Microcapsules 3 loaded with active drugs and capable of being pierced or decomposed by laser are embedded in the drug storage holes 2. The microcapsules The material of 3 is silicon hydrogel material or polymer polyester biomaterial. The diameter of the main body of the IOL is mostly 5.5-6.0mm. Because the drug storage hole and the drug microcapsule occupy part of the periphery, it may be considered to increase the diameter of the IOL main body to 6.5mm, or not, because the drug storage hole and the microcapsule are in the Clo...

Embodiment 2

[0024] see image 3 As shown, the present embodiment differs from the first embodiment in that the drug storage hole 2 is not a cylindrical tunnel penetrating through the IOL main body 1, but is a concave hole.

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Abstract

The invention discloses a drug-carrying type artificial lens capable of being opened by a laser. The drug-carrying type artificial lens capable of being opened by the laser comprises an artificial lens main body, a plurality of drug storing holes with preset intervals are formed in the peripheral surface of the artificial lens main body, and micro-capsules loading active drug and capable of being punched through or resolved by the laser are embedded in the drug-storing holes. A plurality of drug micro-capsules are embedded into the peripheral portion of the artificial lens, the lens is opened to release by the laser on a suitable opportunity to achieve a treatment goal, and relative to a drug sustained releasing system, side effects brought by long-term sustained drug releasing is avoided. Besides the treatment goal of post-operation inflammatory resistance and posterior capsule opacification resistance, the drug-carrying type artificial lens capable of being opened by the laser can be embedded to achieve the purpose of controlling eye diseases aiming at certain diseases of age related macular degeneration, diabetic retinopathy and the like together with the complication of a cataract, and the complications caused by multiple injections of a vitreous cavity and the side effects of systemic administration are avoided or reduced.

Description

technical field [0001] The invention relates to the field of artificial lens technology, in particular to a drug-carrying artificial lens that can be opened by laser. Background technique [0002] At present, the research on the drug release device attached to the intraocular lens is mostly animal experiments, and the drugs of interest are mostly anti-inflammatory drugs. The research content is mainly to control the postoperative inflammatory response and inhibit or delay the formation of posterior capsule turbidity. There are not many related studies on the treatment of posterior segment diseases with drugs loaded on the posterior segment. Some studies have reported that the tension ring sustained release system loaded with bevacizumab (avastin) was implanted and the corresponding concentration can be detected in various parts of the eyeball, but it is only used as a verification delay. The effectiveness of the delivery system has not been combined with clinical efficacy. ...

Claims

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Application Information

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IPC IPC(8): A61F2/16A61M31/00
Inventor 刘奕志黄梓敬柳夏林
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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