134results about How to "Avoid side effects" patented technology

Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.

The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT_2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D₁ and D₂ receptor signaling system, and/or the μ-opioid receptor.

The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia,

wherein R₁, R₂, R_2′ R₅, G, n and W are defined herein.

An ionized physical vapor deposition apparatus (10, 10a, 10b) is provided with an RF element, preferably a helical coil (30), that surrounds space (11) within a vacuum chamber (12) between a target (16) and a substrate holder (14). RF energy, preferably at about 2 MHz or elsewhere in the 0.1 to 60 MHz range, is coupled into the space to form a secondary plasma (29) in a volume (26) of the space between the substrate holder and the main plasma that is adjacent the target. The secondary plasma ionizes sputtered material which is then attracted toward a substrate (15) on the support by a bias on the substrate and/or by an axial magnetic field to impart directionality to the moving ionized sputtered particles to render them perpendicular to the substrate at incidence, so as to coat the bottoms of narrow high aspect ratio features on the substrate. A window (60) of dielectric material such as quartz, either in the wall of the chamber or inside the chamber, or insulation on the coil, protects the coil from adverse interaction with plasma. Shields (100, 200, 300) between the space and the dielectric material prevent sputtered particles coating the dielectric material. The shields are partitioned or slotted to prevent induced currents in the shields. The shields may be biased to control contamination and may be commonly or individually biased to optimize the uniformity of coating on the substrate and the directionality of the flux of ionized material at the substrate. The shield may be formed of a plurality of angled segments (302) that are spaced to facilitate communication of a secondary RF plasma from adjacent the window to the volume of the chamber where the sputtered material is ionized, with the sections angled and spaced to shadow at least most of the target from the window. Alternatively, electrically conductive shield (100) may be provided in close proximity to the window or insulation.

The invention discloses a method for preparing 5-hydroxymethylfurfural by taking glucose as a raw material, which comprises the steps of: mixing the glucose with water according to the mass ratio of 1: 3-10, loading the mixture into a high-pressure reactor, sealing the high-pressure reactor, increasing the reaction temperature to be between 120 and 250 DEG C, injecting liquid carbon dioxide into the reactor, and controlling the pressure to be between 10 and 25MPa; performing the separation of carbon dioxide and a product on supercritical carbon dioxide with the product dissolved therein through a separator during the reaction, and controlling the separation pressure to be between 5 and 8MPa and the separation temperature to be between 25 and 70 DEG C; and discharging the product from the bottom of the separator, and obtaining a 5-hydroxymethylfurfural product through drying, dehydration and crystallization. The method has the advantages of high selectivity of the 5-hydroxymethylfurfural, continuous production, high product content, green and environment-friendly process, and easy industrialized production.

The invention provides a method for preparing Fenton-like reaction catalyst. Inert oxide or a molecular sieve is used as a carrier, and the carrier is loaded with nano-scale iron oxide. The method includes mixing the iron oxide and the carrier with each other and then molding the iron oxide and the carrier to obtain particles; calcining the particles at the temperature of 200-500 DEG C to obtain the Fenton-like reaction catalyst with the particle size of 10-40 mesh. A weight proportion of the iron oxide to the carrier is 1:(0.4-1). The method has the advantages that the Fenton-like reaction catalyst prepared by the aid of the method is high in catalytic activity, selectivity and stability and can be used as Fenton-like oxidation reaction catalyst for advanced treatment of wastewater after the wastewater is subjected to biochemical treatment, accordingly, the catalytic efficiency can be improved in reaction procedures, float mud can be prevented, the COD (chemical oxygen demand) removal rate of the treated wastewater can be obviously increased as compared with existing Fenton treatment, and wastewater treatment discharge requirements can be met; the pH of treated outflow ranges from 7.0 to 8.0, and the treated outflow can be directly discharged without pH regulation; waste mud generated in treatment procedures can be utilized and can be used for producing coatings.

The invention relates to a flame-retardant rigid polyurethane foam heat insulation plate. The flame-retardant rigid polyurethane foam heat insulation plate comprises a component A and a component B, wherein the component A is formed by mixing flame-retardant polyether or flame-retardant polyether polyol, amidogen ether polyol, common polyether polyol, a foam stabilizer, a catalyst, a reactive flame retardant, modified expandable graphite and a foaming agent according to a certain proportion. The component B is isocyanate. The component A and the component B are mixed, and then are subjected to compression molding to obtain the flame-retardant heat insulation plate. According to the prepared flame-retardant rapid polyurethane foam heat insulation plate, flame-retardant testing data exceed a GB8624-2012B1-grade flame-retardant standard, the oxygen index is up to 48.9, and the heat conduction coefficient is about 0.02W/m.k. The flame-retardant rigid polyurethane foam heat insulation plate has excellent compressive strength and bending resistance strength. The flame-retardant rigid polyurethane foam heat insulation plate is suitable for being applied to the fields of flame retardance and heat insulation of building walls, refrigeration houses, refrigerators, solar water heaters and the like.

The invention relates to a preparation method for tacrolimus suspending eye drop liquid. The preparation method comprises the following steps: dissolving the tacrolimus in an organic solvent; filtering and sterilizing the tacrolimus solution through a micropore filtration film; adding the tacrolimus organic solution after sterilization and filtration in injection water; separating out tacrolimus particles with appropriate particle diameter; displacing the solvent by adopting a tangential flow ultrafiltration device; removing organic solvent residue to obtain sterile tacrolimus particle slurry; mixing the slurry with other auxiliary solution after sterilization uniformly to obtain the tacrolimus suspending eye drop liquid. The tacrolimus suspending eye drop liquid prepared by the method meets requirements in sterility and particle diameter, and can effectively improve retention performance of the medicine in eyes; the preparation method is simple and reasonable in technology, and suitable for production on large scale.

The invention discloses a chinese traditional medicine antibiotic hemostatic patch principally composed by a back lining layer, a medicine layer and a antisticking layer, the medicine layer is composed of medicine and substrate, wherein the medicine is composed of plant essential oil having antibacterial activity and chinese traditional medicine having hemostasia activity. The invention provided patch uses plant essential oil and hemostasia chinese traditional medicine as activity component, the plant essential oil has strong antibiotic action and simultaneity can conquer problem of multidrug resistance caused by western medicine antibacterial; the hemostasia chinese traditional medicine can exert the whole action advantage of multi-approach, multi-target, multi-link of chinese traditional medicine, and simultaneity avoides toxic side effect caused by western haemostatic medicine; the plant essential oil is natural percutaneous absorption enhancer that can promote percutaneous absorption of hemostasia chinese traditional medicine and enhance hemostasia activity; matching the plant essential oil and the hemostasia chinese traditional medicine reasonably, possessing advantages of fast effect, antibiotic, good hemostasia effect, small toxic side effect, and source of the raw material is wide which can be obtained cheaply, and the preparation method is simple.

The invention provides compounds of the formula I

wherein the substitutents are as described herein.

Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia, and also provided are pharmaceutical compositions containing such compounds.

The invention discloses a mixed compound medicament of natural medicament components and nitric oxide donors. The mixed compound medicament is characterized in that: the mixed compound medicament is obtained by compounding at least one natural medicament component and at least one nitric oxide donor in any mass concentration ratio, wherein the natural medicament component is a medicinal material with antitumor activity; and the nitric oxide donor is a compound with the ability of releasing nitric oxide. After the mixed compound medicament of the natural medicament components and the nitric oxide donors is applied, the antitumor activity and selectivity of the natural medicament components can be effectively strengthened, and the toxic or side effect of non-natural medicaments can be avoided; meanwhile, the antitumor activity of the nitric oxide is played, so the mixed compound medicament has the ability of remarkable double-effect inhibition on the activity of pathological cells, and can be widely and effectively applied in the treatment of cancer.

The invention relates to a lithium ion battery electrode composite material which comprises an electrode active material particle and a protective film coated on the electrode active material particle. The component of the protective film is one of AlxMyPO4 and AlxMy(PO3)3, or a mixture of the two substances, wherein the valence state of M is k, and M is one or a mixture of more than one of Cr, Zn, Cu, Mg, Zr, Mo, V, Nb, and Ta; 0<x<1, 0<y<1, and 3x+ky=3. The invention also relates to a preparation method of the lithium ion battery electrode composite material, which comprises the following steps: providing a lithium ion battery modifier and the electrode active material particles, wherein the modifier comprises a mixture of a phosphorus source containing phosphate groups, a trivalent aluminium source and a metal oxide in a liquid phase solvent; mixing the electrode active material particles and the lithium ion battery modifier to form a mixture, drying and performing heat treatment of the mixture. In addition, according to the invention, the electrode composite material is applied to lithium ion batteries.

The invention discloses a polylysine nano prodrug micelle with charge turning and targeting functions and preparation and application thereof. The polylysine nano prodrug micelle takes a hydrophobic drug as an inner core, the structure of the hydrophobic drug contains amino, a polylysine chain serves as a shell layer and is composed of 10-25 lysines, the amino of the hydrophobic drug is connected with carboxyl located at the tail end of the polylysine chain through an amido bond, amino located at the tail end of the polylysine chain modifies an upper targeting ligand through an amido bond as well, and beta-carboxyl amidation is performed on amino located at a side chain of the polylysine chain. According to the polylysine nano prodrug micelle with the charge turning and targeting functions and preparation and application thereof, the structure and preparation process of the prodrug micelle are simplified, the prodrug micelle has both the active and passive targeting properties and the pH responding property, the treatment efficiency can be improved, and the toxic and side effects are reduced.

The invention provides a method for extending in vivo half life of protein medicine by making red cell as carrier, which can not only extend the half life of protein medicine, but also reduce medicament consumption, prevent medicament from diffusing to outside the blood vessel, thus reduce the side effects of the medicine. The invention also relates to a protein medicament-erythrocyte compound, the protein medicine employs erythrocyte as carrier to be transferred in vivo.

The present invention provides a unique oral care formulation comprising an anti-irritant amount of a salicylate salt and an effective amount of a taste enhancing agent. Certain embodiments further comprise an anti-inflammatory amount of an irritating agent, for example ketorolac. The oral care formulations may be used on various devices to treat and/or prevent mucosal irritations such as ulcerations.

Disclosed is an AGE production inhibitor or the like, which effectively inhibits the production of an advanced glycation end product (AGE), while having improved biological safety. Specifically disclosed is an AGE production inhibitor or the like, which contains an extract of cherry (preferably blossoms or leaves thereof) and/or a processed product of the extract as an active ingredient. The AGE production inhibitor or the like contains, as an active ingredient, at least one compound that is selected from the group consisting of 1-O-(E)-caffeoyl-ss-D-glucopyranoside, 1-O-(E)-coumaroyl-ss-D-glucopyranoside, 1-O-(E)-cinnamoyl-ss-D-glucopyranoside, kaempferol 3-O-ss-D-glucopyranoside, quercetin 3-O-ss-D-glucopyranoside, kaempferol 3-O-(6"-malonyl)-ss-D-glucopyranoside, and quercetin 3-O-(6"-malonyl)-ss-D-glucopyranoside.

The invention relates to a lithium ion battery electrode cyclic attenuation mechanism evaluating method. With the method adopted, the technical problem that the various failure mechanisms of an integrated battery system are difficult to completely separate can be solved. According to the lithium ion battery electrode cyclic attenuation mechanism evaluating method, anode polar sheets, cathode polarsheets and electrolyte are assembled, so that a plurality of sets of single-layer soft-package integrated batteries can be formed; after formation is performed, empty electricity and full electricitytesting is performed; the anode polar sheets and the cathode polar sheets are taken out, and residual electrolyte is removed; and the anode polar sheets and the cathode polar sheets are assembled into soft-package laminated symmetrical batteries, and the attenuation mechanisms of the symmetrical batteries are cyclically tested and analyzed. A symmetrical battery system is adopted, the failure mechanisms of the anodes or and cathodes are separately studied, the generation of the side reactions of the anodes or cathodes is avoided, a test voltage range is narrow, and electrolyte oxidation is avoided. Compared with a half-battery system, the symmetrical battery system is limited in lithium transmission, and has no extra lithium (lithium sheet) participating in side reactions; compared with abutton-type symmetrical battery system, the soft-package symmetrical battery system ensures the sealing of a whole device and enables long-term cyclic testing.

The invention discloses female safety antimicrobial gel. The female safety antimicrobial gel is prepared from materials A including, by weight, 0.1-1.5 parts of carbomer, 1-15 parts of polyethylene glycol and 68-96 parts of purified water, materials B including, by weight, 1-6 parts of tween 80, 0.05-1 part of aloe extract, 0.05-0.2 part of benzalkonium chloride, 0.05-2 parts of sodium hyaluronate and 0.1-1.5 parts of triethanolamine, and materials C including, by weight, 0.1-0.5 part of germall and 1-3.5 parts of octoxynol. The invention further discloses a preparation method of the female safety antimicrobial gel. The female safety antimicrobial gel can kill sperms, prevent pregnancy, conduct sterilization and disinfection and prevent reproductive tract infections, is small in vagina stimulation and has the two-way protection function.

The invention discloses a genetic evaluation and suit method for individualized tumor therapy. The genetic evaluation and package method includes steps of: 1) extracting a DNA sample of a subject; 2) carrying out target gene PCR amplification, purification, fragmentation and fluorescein labeling on the sample DNA; 3) carrying out gene chip hybridization on fluorescein labeled PCR products to detect SNP sites of the target gene; and 4) analyzing curative effect and toxicity of antitumor drug on the subject, according to the genetic typing results obtained in the step 3). Therapeutic effect evaluation of tumor patient can be conducted through the related genetic typing, thus formulating the most scientific individualized therapy plan to improve efficacy, reduce or even avoid the toxic and side effects.

The invention provides an industrialized production method of miconazole nitrate, pertaining to the technical field of medicine synthesis. The method solves such problems as complex technology, comparatively low yield and purity, and the like in the existing industrialized production method of the miconazole nitrate. The industrialized production method of the miconazole nitrate includes the following steps: a. N-alkylation reaction; b. reducing reaction; c. O-alkylation reaction. The industrialized production method has the advantages of simple technology, no requirement for extracting any intermediate product, high yield and purity, etc.

The invention relates to the technical field of chemical equipment, in particular to an enamel reaction kettle. The enamel reaction kettle comprises a kettle body and a supporting frame; the kettle body comprises an interlayer, a feeding port, a discharging port and a stirring device; the feeding port comprises a first feeding port and a second feeding port; the second feeding port comprises a liquid storage tank, a liquid inlet pipe and a cleaning pipe; uniform charging can be realized in the reaction process and the inner wall of the kettle body can be cleaned completely after reaction; thestirring device comprises a stirring shaft, a stirring blade and a stirring rod; the surfaces of the stirring shaft and the stirring blade are wavy, so the turbulent flow effect is enhanced and the materials are mixed completely; the stirring blade with the length which is increased gradually and the stirring rod at the bottom overcome the deposition phenomenon caused by the gravity of the materials, the reaction efficiency is improved and the problem of non-uniform and incomplete reaction is solved; and the supporting frame is in sliding connection with a main frame through a secondary frame,so that the supporting effect on the kettle body is achieved, and the kettle body can be maintained conveniently from different angles.

A digital traffic switch having DIBOC buffer control has a queue status-based control strategy to limit status traffic on the switch and status buffer requirements. Status messages are transmitted from inputs to outputs when the content status of a logical output queue has changed from “empty” to “not empty”, or vice versa, rather than on a “per cell” request basis. Status messages are transmitted from outputs to inputs when the clearance status of a logical output queue has changed from “not clear to release” to “clear to release”, or vice versa, rather than on a “per cell” grant basis. The status of each logical output queue is monitored at outputs by retaining and updating a single status bit which has a particular binary value when the logical output queue's status is “empty” and the opposite binary value when the logical output queue's status is “not empty”. The status of each logical output queue is monitored at inputs by retaining and updating a single status bit which has a particular binary value when the logical output queue's status is “not clear to release” and the opposite binary value when the logical output queue's status is “clear to release”. Outputs generate (but do not transmit) release grants in a logical order determined by running a grant generation algorithm. Inputs release discrete information units in a logical order determined by running a release algorithm. Status messages for logical output queues are re-transmitted when extra bandwidth is available to remove any inaccurate view of the status of the logical output queues resulting from transmission failures of the original status messages.

The present invention discloses a halogenation reaction method, which comprises: mixing at least an organic compound to be halogenated, a halogenating agent and a solvent capable of being optionally added or being not added and/or a diluent in a super gravity reactor to form a liquid-state reaction system, and carrying out a halogenation reaction to produce the halogenated product, preferably the super gravity level of the super gravity reaction is 5-800 g during the halogenation reaction. According to the present invention, the super gravity reactor such as the super gravity rotating bed reactor is used to perform the halogenation reaction, such that the rapid and microscopic mixing between the organic compound to be halogenated and the halogenating agent can be achieved, various kinds of side reactions caused by the too high local concentration can be effectively avoided, and the yield and the quality of the product can be significantly improved.

Belonging to the field of water splitting new energy technologies, the invention provides a high efficiency water splitting oxygen electrode suitable for natural water and a preparation method. In the electrode, Co-Fe hydrotalcite has a mass percentage content of 3-5%, a particle diameter of 50-00 nm, and a specific surface area of 30-50m<2>/g; the used conductive carbon black is Vulcan XC-72 type, and has a mass percentage content of 7-16%; the used titanium mesh is a plain titanium mesh with equal warp and weft wire diameter density, has a thickness of 0.2-0.5mm and a mass percentage of 79%-90%. According to the preparation method, the Co-Fe hydrotalcite, carbon black and a metal titanium mesh substrate for loading are integrated into the composite electrode. The electrode can carry a simple three-electrode system to be used for oxygen evolution reaction in natural water and neutral non-buffer solutions, including natural seawater and neutral sodium chloride solutions, etc. The preparation method is simple and is easy to realize industrial production, and has no side reaction influence.

The invention relates to a method for modifying an anode active material of a lithium ion battery, comprising the following steps of: stirring and mixing hydrolysis liquid of salt compounds containing metal elements with the anode active material for over one hour, and adjusting the pH value of a mixture to be 2-10; then removing a solution by centrifugation in a centrifugal machine and flushing the anode active material with a water-soluble liquid until the pH value of the flushing liquid is between 1 and 7; drying and sintering the flushed anode active material in the presence protective gases; removing an excessive solution and hydrolysate of metal ions by centrifugal treatment to avoid metallic oxide from being locally deposited on the surface of the active material and uniformly redistribute the metal oxide on the surface of the active material; and flushing the active material with a hydrophilic substance, thereby avoiding other materials from being resided on the surface of theactive material, further avoiding the side effect of the lithium ion battery and improving the overall performance of the lithium ion battery.

The invention discloses a double-drug-loading carrier-free nanoparticle preparation and a preparation method thereof. The double-drug-loading carrier-free nanoparticle is not added with any carrier and is only composed of a phototherapy drug and a chemotherapy drug, and the phototherapy drug is a drug with photosensitizer properties, namely chlorin e6; wherein the chemotherapeutic drug is a camptothecin drug, and the camptothecin drug is one of camptothecin, 10-hydroxycamptothecine or 7-ethyl-10-hydroxycamptothecine. The double-drug-loading carrier-free nanoparticles are prepared by combiningan anti-solvent precipitation method with a high-pressure homogenization method or combining an alkali dissolution and acid precipitation method with the high-pressure homogenization method, the particle size is 140-170 nm, a freeze-drying protective agent can be added for freeze-drying, and the particle sizes before and after freeze-drying redissolution have no significant difference. According to the double-drug-loading carrier-free nanoparticles, the synergistic effect of phototherapy-chemotherapy is achieved, the anti-tumor effect is remarkable, meanwhile, the problems of safety, unclear in-vivo metabolism and the like caused by carrier synthesis are avoided, the biocompatibility is good, and the potential clinical application value is achieved.

The invention relates to application of N-(3- pyridine formex oxygen radical)-3, 5- dimethyl-1- amantadine or pharmaceutically-acceptable salt for treating vascular dementia.

The invention provides a body-building and bone-strengthening glutinous-rice medicinal wine prepared by adopting the synchronous fermentation process. The body-building and bone-strengthening glutinous-rice medicinal wine is prepared by performing clinical experiments and testing repeatedly and conforms to the theory of traditional Chinese medicine. The body-building and bone-strengthening glutinous-rice medicinal wine is prepared from brewing raw materials including 20 Chinese herbal medicines, glutinous rice, water, distiller's yeast and wine yeast. The 20 Chinese herbal medicines comprise medicinal cyathula root, polygonum multiflorum, the fruit of Chinese wolfberry, radix asparagi, radix ophiopogonis, dried rehmannia root, prepared rehmannia rehmannia, Chinese angelica, ginseng, cinnamon, rhizoma dioscoreae for Henan province of China, cistanche, schisandra chinensis, eucommia, dodder, poria, rhizoma alismatis, pulp of dogwood fruit, morinda officinalis and polygala tenuifolia. The glutinous rice and the Chinese herbal medicines are mixed and fermented synchronously according to the theory of traditional Chinese medicine and the fermenting process of rice wine to prepare the glutinous-rice medicinal wine which can be drunken by people in daily life to achieve the effects of building body and strengthening bone. The glutinous-rice medicinal wine carries forward and further develops the traditional Chinese medicine and the traditional wine culture and can an be drunken all the year round by the patients to take a unique and good effect on preventing and treating rheumatic arthralgia, achiness and weakness in loin and knees, lassitude and asthenia, arthralgia and other symptoms.

The invention discloses a method for safely producing nitrogen-containing super activated carbon. The method comprises the step of feeding ammonia gas in a KOH activation process for activation; reaction between the ammonia gas and carbon at high temperature can be used for producing a developed pore structure; furthermore, reaction between the ammonia gas and potassium can be used for solving the problem of difficult release of the potassium in the KOH activation process, and the aim of doping a nitrogen element into the surface of activated carbon is fulfilled. By the adoption of the method, the nitrogen-containing activated carbon with a high specific surface area can be prepared, and the severe production safety problem caused by production and release of elemental potassium in the process of activating KOH to produce the super activated carbon can be solved; a new technical way is supplied to industrial production of the super activated carbon through a KOH activation method.

The invention discloses the use of human interleukin 32 in the preparation of medicaments for treating or preventing influenza A virus infection. Clones of splicing isoforms IL-32(alpha, beta, gamma, delta, epsilon and zeta) of IL-32 are cloned and established by using a molecular biological method; MDCK cells are transfected with the clones; and thus, the applicant has found that MDCK cells in which all subtypes of the human interleukin 32 are overexpressed are improved in resistance to influenza A viruses. Different IL-32 subtypes show different inhibition effects on the replication of the influenza A viruses. The IL-32 gamma has the most obvious anti-influenza A virus effect. And only the IL-32 gamma is of a secretor type. The human interleukin 32 is a critical antiviral gene in immunoreactions of a host. The applicant is the first one to put forward that the human interleukin 32 has an extremely effective anti-influenza A virus function and to point out that the human interleukin 32 has an application prospect in developing anti-influenza A virus medicaments for effectively preventing and treating influenza A virus infection.