209results about How to "Avoid side effects" patented technology

The invention provides a highland cooperative control method fusing a graph convolutional neural network and reinforcement learning, through controlling urban road traffic signal lamps, an expressway ramp signal machine and a variable speed limit unit, expressway traffic congestion is relieved, the urban traffic passing efficiency is improved, road driving vehicles are controlled by means of the signal lamps and the speed limit unit, and the traffic efficiency is improved. Traffic flow scheduling optimization in a global road network is achieved; the whole structure adopts a distributed cooperative control framework, is controlled by a decision-making agent, and performs autonomous decision-making and adjustment according to real-time traffic conditions, so that the adaptability and robustness of the system are enhanced, and the defects of large data calculation amount, difficulty in processing, control strategy lag and the like caused by traditional centralized control are effectively avoided; the graph convolutional neural network model is constructed to aggregate the feature information of the peripheral decision intelligent agent, and the control weight is dynamically allocated, so that the information sharing capability is enhanced, the suboptimal decision caused by lack of comprehensive perception of the surrounding environment is prevented, and the cooperation efficiency of the whole system is improved.

The invention discloses a self-assembled nano material for targeting liver and improving fatty liver as well as a preparation method and application of the self-assembled nano material, and belongs to the technical field of preparation of novel nano materials. According to the invention, a self-assembled nano material is formed by MOF, thyroid hormone and an ASGR1 antibody. The MOF material has good preservation performance, can effectively remove active oxygen in cells and intercellular substances, and reduces damage of the active oxygen to liver cells. The thyroid hormone is gathered in the MOF, the thyroid hormone can be accurately released after the MOF is targeted to the liver, the effect of the thyroid hormone on relieving the fatty liver degree is efficiently achieved, and toxic and side effects of the thyroid hormone on other organs of the whole body are effectively avoided. The surface of MOF is modified with an ASGR1 antibody, the antibody can accurately target the self-assembled nano-material to the surface of a liver cell membrane, and the ASGR1 antibody can effectively inhibit ASGR1 on the surface of the liver cell membrane, so that the self-assembled nano-material can effectively promote discharge of cholesterol in cells.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood and a preparation method thereof. The composition is prepared by carefully selecting a plurality of traditional Chinese medicinal materials with the effects of tonifying qi and blood, regulating menstruation and nourishing blood and combining the traditional Chinese medicinal materials according to a specific proportion, and comprises ginseng, codonopsis pilosula, lucid ganoderma, astragalus membranaceus, angelica sinensis, peach kernels, donkey-hide gelatin, longan aril, Chinese dates, Chinese yams, radix polygonati officinalis, fructus lycii, poria cocos, roses and pericarpium citri reticulatae. The traditional Chinese medicine composition is prepared through the processes of extraction, double-effect concentration, filtration, blending and the like through scientific proportioning and a unique processing technology, aims to effectively improve the symptom of scanty menstruation caused by deficiency of qi and blood of women, recover normal menstruation, condition the body and improve the overall health level, has good safety and effectiveness, and is worthy of popularization and application. And a new choice is provided for health management of women. The traditional Chinese medicine composition for tonifying qi and blood and treating hypomenorrhea caused by deficiency of qi and blood is safe, small in side effect, efficient, convenient and good in taste.

The invention discloses a nano-carrier based on charge crosslinking, a preparation method of the nano-carrier and application of the nano-carrier as a tumor chemotherapy drug. Wherein the nano-carrier is formed by assembling two polymer chains with positive and negative charges through electrostatic interaction, a precursor ligand on a polymer chain B releases an organic ligand under exogenous or endogenous stimulation, and competes for metal ions on a polymer chain A with positive charges to generate a metal complex in situ, and meanwhile, the electrostatic interaction of the nano-carrier is weakened, so that the metal complex is formed. The dissociation of the nano-carrier is caused, a macromolecular chain B containing an organic ligand is released, and the effect of tumor chemotherapy or immunoregulation is achieved. The method is simple to operate, short in time consumption and mild in reaction condition; the material is good in biocompatibility and high in safety degree. Pharmacodynamic experiments in some embodiments show that the nano-carrier can effectively kill the breast cancer and trigger cellular immunogenic death, meanwhile, tumor cell metastasis is inhibited, and a new thought and means are provided for the clinical problem of breast cancer lung metastasis urgently needing to be solved at present.

The invention relates to a parameter configuration method and device in a multi-computing-cluster environment, computer equipment, a computer readable storage medium and a computer program product. The method comprises the following steps: determining a value space of each database parameter in a to-be-configured database; according to the plurality of query tasks, determining a performance index function for the to-be-configured database; traversing each value point in the value space, and executing a plurality of query tasks according to database parameters represented by the traversed value points to obtain execution index scores of performance index functions under the database parameters represented by the traversed value points; and determining a target value point in the targeted value space, and performing parameter configuration on the to-be-configured database according to database parameters represented by the target value point. By adopting the method, the overall performance of the database can be improved, and meanwhile it is guaranteed that the computing clusters under different hardware configurations can play the optimal performance.

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

The invention relates to the technical field of adjuvant therapy monitoring, in particular to an anorectal disease adjuvant therapy monitoring system and method based on a radix scrophulariae extract. The method comprises two stages of system initialization and adjuvant therapy monitoring, in the initialization stage, initialization setting is completed, and a dynamic monitoring code is generated to guarantee data transmission security; in the auxiliary treatment stage, baseline data are collected, abnormal values are removed, then personalized baselines are generated, the drug dosage and the release rate are adjusted according to the baseline data, meanwhile, pressure, temperature, blood flow and electrophysiological data are monitored in real time, key indexes are calculated, monitoring labels are generated, the physiological indexes are standardized, the treatment effect is comprehensively evaluated, and classification is conducted. The dynamic trend is analyzed by adopting a polynomial fitting method, an evaluation result is generated, the drug release rate and dosage are dynamically optimized in combination with real-time monitoring data and patient feedback, and fine treatment is further performed by adopting a feedback adjustment mechanism. According to the invention, efficient auxiliary treatment and intelligent monitoring of anorectal diseases are realized.

The invention belongs to the technical field of biochemical engineering, and particularly relates to a Pickering emulsion microcapsule of interface immobilized lipase as well as a preparation method and application of the Pickering emulsion microcapsule. The preparation method of the Pickering emulsion microcapsule comprises the following steps: ultrasonically dispersing silicon oxide nanoparticles which have an emulsifying function and can adsorb enzyme into an organic solvent to serve as an oil phase, dissolving lipase into a buffer solution to serve as a water phase, mixing the water phase and the oil phase, and carrying out ultrasonic dispersion to obtain the Pickering emulsion microcapsule. And then adding a silane coupling agent, organic amine and an organic solvent, and carrying out interface gel-sol treatment to obtain the Pickering emulsion microcapsule. The Pickering emulsion microcapsule disclosed by the invention has better high temperature resistance and pressure resistance, and can realize efficient preparation of epoxide in a fixed bed continuous enzyme catalysis olefin epoxidation reaction.

The invention belongs to the technical field of tumor vaccines, and discloses a personalized tumor vaccine based on hydrogel and a preparation method and application thereof, the preparation method comprises the following steps: adding a chemotherapeutic drug into a mixed solution of polyphenol and metal ions, uniformly mixing, adjusting the pH value of the solution, and reacting for 2-8 hours to obtain a metal polyphenol nano-carrier loaded with the chemotherapeutic drug; co-culturing the obtained metal polyphenol nano-carrier loaded with the chemotherapeutic drug and tumor cells for 12-48 hours, and inducing the tumor cells to generate immunogenic cell death, wherein the concentration of the metal polyphenol nano-carrier loaded with the chemotherapeutic drug is 1-20 [mu] g / mL; the tumor cell suspension in the ICD state and the STING agonist solution are mixed with the sodium alginate solution, and the personalized tumor vaccine is obtained. The ICD is induced in vitro by the chemotherapeutic drug, so that the toxic and side effects of systemic administration are reduced, the types of antigens are enriched, and a powerful guarantee is provided for the vaccine to activate a strong in-vivo anti-tumor immune response.

According to the N-type IBC battery and the preparation method thereof provided by the embodiment of the invention, the boron-containing aluminum coating is formed in the first region of the n-type raw silicon region and the laser doping treatment is carried out, so that high-concentration boron doping can be carried out on the n-type raw silicon region to form the p-type doped region; the side effect caused by the doping mode of the traditional tubular boron source is avoided, and the conversion efficiency of the cell is ensured, so that the problems that the forming mode of the p-type doped region of the existing N-type IBC cell is complicated in process and more in side effect, and the photoelectric conversion efficiency of the cell is easily influenced are solved.

The invention relates to an oncolytic virus VSV-aPDL1 / aCD137 for expressing a bispecific antibody as well as a construction method and application of the oncolytic virus VSV-aPDL1 / aCD137. The preparation method comprises the following steps: firstly designing aPDL1 / aCD137, then synthesizing an aPDL1 / aCD137 gene in vitro, amplifying the aPDL1 / aCD137 gene, connecting the aPDL1 / aCD137 gene to a pT7-VSV whole genome plasmid to obtain a virus whole genome plasmid pT7-VSV-aPDL1 / aCD137, and then co-transfecting the plasmid and a helper plasmid to a 293T cell to obtain the VSV-aPDL1 / aCD137 oncolytic virus. According to the present invention, the local anti-tumor immune response of the tumor is activated through the virus, the infiltration of the lymphocyte to the tumor tissue is recruited, the anti-PD-L1 / anti-CD137 bispecific antibody is expressed, the inhibition of the PD-1 / PD-L1 pathway on the T cell is blocked, and the inhibition signal of the PD-1 / PD-L1 pathway on the tumor cell surface is reversed into the CD137 signal of the activated T cell, such that the functional failure of the T cell caused by the PD-1 / PD-L1 pathway can be blocked, and the anti-tumor immune response of the tumor can be inhibited; the function and viability of T cells can be further improved, long-term immune surveillance on tumors is realized, and long-acting anti-tumor immune response is generated. Experiments show that the oncolytic virus can significantly prolong the lifetime of tumor-bearing mice, and a new strategy is provided for development of solid tumor drugs.

The invention provides sonodynamic targeted drug-loaded nanoparticles as well as a preparation method and application thereof, and belongs to the field of targeted drug delivery preparations. The sonodynamic targeting drug-loading nanoparticle provided by the invention comprises a porous carrier, a drug loaded in the porous carrier and a targeting ligand chemically modified on the outer surface of the porous carrier, the porous carrier is a hydrogen bond organic framework; a construction unit of the hydrogen bond organic framework is a metalloporphyrin complex. After the sonodynamic targeting drug-loading nano-particle provided by the invention is injected into a 4T1 tumor-bearing BALB / c mouse body for 6 hours, fluorescence of the sonodynamic targeting drug-loading nano-particle is observed on a tumor, and a signal is continuously enhanced; after 14 days of administration, the tumor growth is obviously inhibited, and good targeting and anti-tumor effects are achieved.

The invention provides core-shell structure nanoparticles with a mediated microenvironment for rheumatoid arthritis treatment and a preparation method thereof.The preparation method comprises the steps that a calcium peroxide precursor is dissolved in absolute ethyl alcohol containing a surfactant, and calcium peroxide nanoparticles are obtained by adding an ammonia water solution and a hydrogen peroxide solution; the preparation method comprises the following steps: carrying out surface treatment on calcium peroxide nanoparticles by using tannic acid to form a tannic acid molecular layer on the surfaces of the calcium peroxide nanoparticles so as to obtain tannic acid modified calcium peroxide nanoparticles; and forming a metal phenolic network shell on the surface of the tannic acid modified calcium peroxide nano-particle by using cerium acetate to obtain the core-shell structure nano-particle.

The invention belongs to the technical field of biological medicine, and particularly discloses a hangover-alleviating and liver-protecting preparation which comprises a liver-protecting agent layer, a first coating layer, a hangover-alleviating layer and a second coating layer which are sequentially arranged from inside to outside, the component of the liver-protecting agent layer is a mixture A, the component of the hangover-alleviating layer is a mixture B, the component of the first coating layer is a mixture C, the component of the second coating layer is a mixture B, and the component of the third coating layer is a mixture C; the component of the coating layer II is a mixture D. The hangover-alleviating and liver-protecting preparation provided by the invention is of a multi-layer structure, and can continuously release active ingredients for a long time, so that the concentration of medicines in blood is kept stable; meanwhile, side effects caused by too high drug concentration in a short time can be avoided.

The nitric oxide gel for treating endometrial injury is composed of a gel matrix and a nitric oxide gas solution, the nitric oxide gas solution is uniformly dispersed in the gel matrix, and the volume ratio of the gel matrix to the nitric oxide gas solution is 3: 1-1: 3. The gel matrix is composed of one or more of poloxamer and derivatives thereof, povidone, carbomer and cellulose derivatives, and the nitric oxide gas solution is formed by dispersing nitric oxide gas in absolute ethyl alcohol or water-free and oxygen-free polyhydric alcohol which is in a liquid state at the temperature of 25 DEG C. According to the nitric oxide gel for treating the endometrial injury, the limitation bottleneck of the nitric oxide gel for treating the endometrial injury is overcome, meanwhile, the safe, effective, convenient and economical requirements of clinical treatment are met, and the effect of nitric oxide on treating the endometrial injury is fully exerted.

The invention discloses a dynamic living cell monitoring method which comprises the following steps: acquiring a cell scanning picture group of living cells growing in a culture container under specified conditions, and preprocessing the pictures; inputting the preprocessed cell scanning picture group into the trained cell recognition model, and outputting a cell growth state picture group; inputting the cell growth state diagram group into a trained survival rate calculation model, and outputting the survival rate of cells in each cell growth state diagram; drawing the obtained cell survival rate values into a cell survival rate-time curve graph; and combining the generated cell survival rate-time curve graph with a nonlinear regression statistical method, and selecting specified parameters to calculate the half-inhibition concentration value of the drug effect. Monitoring the growth state of the cells under specified conditions, and calculating the survival rate of the cells and the half-inhibition concentration value of the drug effect based on the data; the efficiency and the accuracy in the fields of medicine research and development, medicine screening, treatment scheme effects and the like can be remarkably improved.

The invention discloses an ultrasonic activation type carrier-free nano-drug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The nano-drug is formed by self-assembly of a sound-sensitive agent and a chemotherapy prodrug, the sound-sensitive agent is an organic small molecule capable of generating ROS through ultrasonic irradiation, and the chemotherapy prodrug is an ROS response type SN38 prodrug. Only after the carrier-free nano-drug provided by the invention is subjected to ultrasonic irradiation, the sound-sensitive agent can generate active oxygen, further activate the chemotherapeutic prodrug and release the active substance of the chemotherapeutic drug to induce tumor cell apoptosis, the tumor treatment effect is improved in an ultrasonic triggering manner, and toxic and side effects caused by non-specific distribution of the chemotherapeutic drug are avoided. The preparation method disclosed by the invention is simple and mild in reaction condition, and has great potential in the fields of preparation and application of tumor drugs.

The invention discloses a photo-thermal response type composite antibacterial wound dressing as well as a preparation method and application thereof, and relates to the technical field of antibacterial dressings. The wound dressing comprises a nanofiber membrane capable of generating photo-thermal response to near-infrared light; the nanofiber membrane is a spinning product obtained by electrostatic spinning of a spinning solution prepared from polyvinyl alcohol, polyacrylic acid and a core-shell structure composite material; the composite material with the core-shell structure is a composite material with a core-shell structure formed by taking a silver nanorod as a core and mesoporous silica as a shell; wherein the mesoporous silica shell of the composite material with the core-shell structure is doped with an antibacterial drug. The antibacterial agent and the nano-silver in the composite material with the core-shell structure are used for synergistically resisting bacteria, so that the usage amount of the nano-silver is reduced, and the cytotoxicity of the nano-silver is relieved; according to the invention, the problems of cytotoxicity of nano-silver, tedious preparation process of the self-stripping antibacterial dressing, complex components and the like are relieved.

The invention relates to the technical field of medicinal chemistry, in particular to application of a compound Resinacein S or a derivative thereof in preparation of a medicine for preventing or treating obesity or related metabolic complications. The invention also provides an application of the compound Resinacein S or the derivative thereof in preparation of medicines for preventing or treating obesity or related metabolic complications. Researches find that the compound Resinacein S has the effect of preventing and treating obesity, the action mechanism is that fat accumulation is reduced by increasing energy metabolism of the whole body, the effects of reducing body weight and preventing and treating obesity are achieved, and compared with a traditional weight-reducing medicine for reducing body weight by inhibiting appetite, the compound Resinacein S does not prevent and treat obesity by interfering with appetite, and the effect is obvious. And side effects such as gastrointestinal discomfort and cardiovascular risk caused by appetite intervention are avoided.

The invention discloses a carnosine targeting a IIB type activin receptor and a preparation method and application of the carnosine, and the amino acid sequence of the carnosine targeting the IIB type activin receptor is as shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The value of the equilibrium dissociation constant KD of the carnosine and the IIB type activin receptor ranges from 0.514 [mu] M to 1.91 [mu] M. The method disclosed by the invention adopts a multi-technology integration strategy of in vitro digestion simulation, mass spectrum identification, molecular docking, affinity verification and cell function experiment, and has the advantages of high efficiency and strong targeting property. The invention also aims to provide application of the carnosine in preparation of functional food or medicines for preventing and / or treating sarcopenia and promoting muscle growth.

The invention relates to the technical field of immune carriers, in particular to immune carrier microspheres loaded with individualized MHC-II binding polypeptide and vaccine preparation and application of the immune carrier microspheres loaded with the individualized MHC-II binding polypeptide. The core microsphere is loaded with individualized MHC-II binding polypeptide, the sequence of the MHC-II binding polypeptide is obtained by predicting and screening based on an HLA genotyping result, and each HLA allele corresponds to at least one high-affinity MHC-II binding polypeptide; and the shell is a glucan or other polymer coating layer. The preparation method has the advantages that the T epitope and the B epitope are separately subjected to immune competitive inhibition inside and outside the microspheres, so that a better immune effect is obtained. The antibody avoids cross reaction side effects; carrier molecule diversity is reduced, and side effects caused by T cell over-activation are avoided; th1 epitopes and Th2 epitopes can be contained in the microspheres, so that antibody immunity and T cell immunity functions are generated; the particle size of the microspheres is controllable, and the immunologic function can be achieved without adjuvants.

The present invention discloses an axial load testing method, which is applied to an axial load testing system. The axial load testing system comprises a strain acquisition device, a welding terminal and a strain gauge module. The strain gauge module comprises at least two groups of strain gauges, each group of strain gauges comprises two strain gauges, the directions corresponding to the two strain gauges are vertical directions, and at least two groups of strain gauges are symmetrical structures. The strain acquisition device is connected to each strain gauge through a welding terminal, and a target bridge circuit is formed between the welding terminal and the strain gauge module through a preset connection method. The method comprises: when it is detected that the axial load testing system is connected to a component to be tested, obtaining measured strain data corresponding to the strain gauge module through the strain acquisition device; determining target strain data of the component to be tested according to the measured strain data corresponding to the strain gauge module; and generating an axial load corresponding to the component to be tested according to the target strain data and pre-acquired parameters of the component to be tested.

This invention discloses a photothermal responsive multifunctional composite coating, its preparation method, and its application, relating to the field of antibacterial nanomaterials technology. The composite coating comprises an electrophoretic deposition onto a substrate using an electrophoretic solution formulated with chitosan and electrospun short fibers. The electrospun short fibers are prepared by electrospinning a spinning solution formulated with polylactic acid and a core-shell composite material, followed by plasma treatment and fluffing. The core-shell composite material is a composite material with a silver nanorod core and a mesoporous silica shell; wherein the silver nanorods encapsulate gold bipyramidal seeds. The core-shell structured silver nanoparticle antibacterial agent provided by this invention significantly alleviates the problems of cytotoxicity of silver nanoparticles and limited functionality as a surface modification material for bone implants.

The invention discloses a plaster for treating osteoarthrosis and a preparation method thereof, and relates to the field of plasters for treating osteoarthrosis, and the plaster is prepared from the following raw materials: 14-18 parts of rhizoma atractylodis, 58-62 parts of garden balsam stem, 14-18 parts of cyathula officinalis, 8-12 parts of radix aucklandiae, 8-12 parts of gentiana macrophylla, 48-52 parts of clove root, 14-18 parts of cortex acanthopanacis, 8-12 parts of fructus cnidii, 98-102 parts of native copper, 14-18 parts of acorus gramineus, 8-12 parts of cinnamon, 48-52 parts of angelica sinensis and 48-52 parts of gastrodia elata. , 8-12 parts of Sichuan monkshood, 8-12 parts of pinellia ternate, 48-52 parts of myrrh, 48-52 parts of lycopodium clavatum, and 8-12 parts of dendrobe. The prepared plaster can be conveniently attached to the joint of a patient, stimulation of operations, anesthesia and the like is avoided, injury of the operations to the body is avoided, a series of toxic and side effects of oral medicines and the like are avoided, and the plaster is simple and effective to use; the cut plaster can be used for conveniently, simply, safely and effectively treating various osteoarthropathy such as cervical spondylosis, hyperostosis, lumbar disc herniation, rheumatism, rheumatoid, scapulohumeral periarthritis, arthritis, ankylosing spondylitis, fracture, traumatic injury and the like.

The invention discloses an application of an intestinal strain in preparation of a cholesterol-lowering product, and belongs to the technical field of microbial medicines. The intestinal bacterial strain is Oscillibacter ruminant, the viable bacteria concentration of the intestinal bacterial strain is controlled to be (4.8-5.2) * 10 < 9 > CFU / mL, the intestinal bacterial strain can be prepared into bacterial liquid, freeze-dried powder, capsules or tablets and other dosage forms, and pharmaceutically acceptable auxiliary materials such as lactose and microcrystalline cellulose can be added. According to the cholesterol-lowering product, the total cholesterol, triglyceride and low-density lipoprotein cholesterol level of an object can be remarkably reduced under the action of peste des petits ruminants, and meanwhile, the high-density lipoprotein cholesterol level is increased; in addition, abnormal blood glucose induced by high-fat diet can be improved, arterial lipid accumulation is reduced, and the plaque area proportion of atherosclerotic lesions is improved.

The invention discloses a formula and a preparation method of a plaster. The plaster is prepared from the following raw material medicines by weight: 40g of lycopodium clavatum, 45g of loofah sponge, 50g of fructus forsythiae, 50g of raw bighead atractylodes rhizome, 50g of raw radix paeoniae alba, 50g of pawpaw, 60g of caulis spatholobi, 1000g of a hot melt adhesive matrix, 18g of laurocapram powder and 100g of far infrared ceramic powder. The traditional Chinese medicine composition is used for treating pharyngeal diseases, does not simply improve local pharyngeal lesions, focuses on local and overall dialectical combination from regulating qi, blood, yin and yang of viscera, regulates qi and blood running balance of the whole body, treats both symptoms and root causes, and is free of toxic and side effects. The traditional Chinese medicine composition can effectively treat and relieve local clinical symptoms of the pharyngeal cavity caused by different syndromes of pharyngeal diseases caused by various pathogenesis, adjust the balance of the body on the whole and improve the overall condition of the body.

The invention discloses a preparation method of 6-phenyl-2, 3, 4, 5- The invention discloses a 2, 2 '-bipyridine platinum (II)-guanine N-heterocyclic carbene complex and a preparation method and application thereof, and particularly relates to the complex shown in the specification, the complex has dual inhibitory activity on tumor cells and tumor stem cells at the same time, the problem of platinum drug resistance caused by the tumor stem cells, glutathione and other proteins can be solved, and the drug resistance of the tumor cells and the glutathione can be improved. The compound can be used for preparing drugs for treating various malignant tumors, especially drugs for treating malignant tumors resistant to existing chemotherapeutic drugs. The preparation method is simple and easy to operate. In addition, the 6-phenyl-2, 2 '-bipyridine ligand disclosed by the invention contains carbon anions with relatively strong electron donating ability, and compared with a terpyridine ligand, the 6-phenyl-2, 2'-bipyridine ligand disclosed by the invention can further stabilize a metal ion center, so that the ability of resisting GSH interference is improved, and better stability is shown.

The invention discloses a benidipine hydrochloride tablet. The benidipine hydrochloride tablet is a preparation formed by coating a tablet core with a coating solution, the tablet core is formed by mixing and pressing material particles with the following particle sizes in proportion: gt; 0.8%-8% of 20 meshes, 5%-20% of 20-40 meshes, 9%-21% of 40-60 meshes, 15%-48% of 60-80 meshes and 20%-51% of 80-100 meshes; 3-21% of 100 mesh; the material particles comprise the following raw and auxiliary materials in parts by weight: 2-5 parts of benidipine hydrochloride, 76-99 parts of a diluent, 1-2 parts of an adhesive and 0.5-1.5 parts of a lubricant. According to the invention, a specific process of stirring, cutting and atomizing is adopted, so that the raw and auxiliary materials in the tablet are uniformly mixed, material particles with specific granularity are easily prepared for tabletting, the preparation process is simple, and the obtained tablet has the advantages of low content of related substances, stable property, quick dissolution and quick effect, and has practical popularization and application values.

The invention discloses concentration equipment for sea cucumber peptide and a use method of the concentration equipment, and belongs to the technical field of sea cucumber peptide concentration. Comprising a concentration flask and an arc heating cover arranged at the outer bottom of the concentration flask in a covering mode, and an additive injection unit and a driving unit used for driving the additive injection unit to conduct servo rotation are arranged on the upper side of the concentration flask. Reagents needing to be added in the sea cucumber peptide concentration process are directly injected into a container, different from traditional one-time injection and mixing, an active agent is smeared on the inner wall of a concentration flask through an arc wiping sleeve on an active agent injection mechanism, and an active coating attached to the inner wall is formed; the local excessive inhibition effect caused by adding a large amount of active agent at one time can be avoided, the generation of foam is effectively inhibited, the use amount of the active agent can be reduced, the residual amount of the active agent in a final product can be reduced, and the purity of the product is improved.

The invention discloses an emotion regulation and sleep improvement method based on audio and video combination and essential oil sniffing, comprising the steps of S1, brain wave detection and state evaluation, S2, audio and video prescription generation, S3, essential oil sniffing, S4, multi-mode coordinated regulation, S5, effect evaluation and strategy optimization, S6, sleep triggering and wakeup intervention, and S7, sleep improvement. And a user interaction and preference setting step. The emotional state is evaluated by collecting the physiological signals of the user, the audio and video prescription and the essential oil formula are dynamically matched based on the evaluation result, time sequence cooperation of audio and video content and essential oil release is achieved, and therefore accurate intervention on emotion and sleep is achieved on the multi-sensory level; self-adaptive adjustment can be carried out according to individual differences of users and real-time feedback, the effects of emotion adjustment and sleep improvement are remarkably improved, meanwhile, side effects of drugs are avoided, and the method has the advantages of being safe, convenient to use and high in individuation.