37results about How to "Avoid side effects" patented technology

The invention belongs to the field of biological medicines, and relates to a drug-loaded nano-vesicle as well as a preparation method and application thereof. The drug-loaded nano-vesicle comprises a vesicle core and a drug-loaded nano-vesicle, wherein the vesicle core comprises siRNA (small interfering Ribonucleic Acid) capable of specifically targeting and silencing an NR1D1 gene; the vesicle membrane is formed by fusing an erythrocyte membrane, a macrophage membrane, cardiolipin, cholesterol and lecithin. The drug-loaded nano-vesicle can specifically target macrophages in a sepsis immunosuppression stage, has an intracellular response release function, recovers BMAL1 and IGF2BP2-ATP6V1B2 / ATP6V0c axis functions by inhibiting NR1D1 expression, reconstructs a macrophage phagocytosis function and lysosome-dependent bacterium removal capability, and can be used for preparing a drug-loaded nano-vesicle with a specific targeting function. The survival rate of sepsis immunosuppression model animals is obviously improved; and the bacterial load is reduced. Compared with a traditional electroporation method, the preparation method disclosed by the invention has the advantage that the encapsulation efficiency of siRNA is remarkably improved.

The invention discloses a carnosine targeting a IIB type activin receptor and a preparation method and application of the carnosine, and the amino acid sequence of the carnosine targeting the IIB type activin receptor is as shown in SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The value of the equilibrium dissociation constant KD of the carnosine and the IIB type activin receptor ranges from 0.514 [mu] M to 1.91 [mu] M. The method disclosed by the invention adopts a multi-technology integration strategy of in vitro digestion simulation, mass spectrum identification, molecular docking, affinity verification and cell function experiment, and has the advantages of high efficiency and strong targeting property. The invention also aims to provide application of the carnosine in preparation of functional food or medicines for preventing and / or treating sarcopenia and promoting muscle growth.

The invention relates to the technical field of immune carriers, in particular to immune carrier microspheres loaded with individualized MHC-II binding polypeptide and vaccine preparation and application of the immune carrier microspheres loaded with the individualized MHC-II binding polypeptide. The core microsphere is loaded with individualized MHC-II binding polypeptide, the sequence of the MHC-II binding polypeptide is obtained by predicting and screening based on an HLA genotyping result, and each HLA allele corresponds to at least one high-affinity MHC-II binding polypeptide; and the shell is a glucan or other polymer coating layer. The preparation method has the advantages that the T epitope and the B epitope are separately subjected to immune competitive inhibition inside and outside the microspheres, so that a better immune effect is obtained. The antibody avoids cross reaction side effects; carrier molecule diversity is reduced, and side effects caused by T cell over-activation are avoided; th1 epitopes and Th2 epitopes can be contained in the microspheres, so that antibody immunity and T cell immunity functions are generated; the particle size of the microspheres is controllable, and the immunologic function can be achieved without adjuvants.

This invention discloses a photothermal responsive multifunctional composite coating, its preparation method, and its application, relating to the field of antibacterial nanomaterials technology. The composite coating comprises an electrophoretic deposition onto a substrate using an electrophoretic solution formulated with chitosan and electrospun short fibers. The electrospun short fibers are prepared by electrospinning a spinning solution formulated with polylactic acid and a core-shell composite material, followed by plasma treatment and fluffing. The core-shell composite material is a composite material with a silver nanorod core and a mesoporous silica shell; wherein the silver nanorods encapsulate gold bipyramidal seeds. The core-shell structured silver nanoparticle antibacterial agent provided by this invention significantly alleviates the problems of cytotoxicity of silver nanoparticles and limited functionality as a surface modification material for bone implants.

The invention discloses an application of an intestinal strain in preparation of a cholesterol-lowering product, and belongs to the technical field of microbial medicines. The intestinal bacterial strain is Oscillibacter ruminant, the viable bacteria concentration of the intestinal bacterial strain is controlled to be (4.8-5.2) * 10 < 9 > CFU / mL, the intestinal bacterial strain can be prepared into bacterial liquid, freeze-dried powder, capsules or tablets and other dosage forms, and pharmaceutically acceptable auxiliary materials such as lactose and microcrystalline cellulose can be added. According to the cholesterol-lowering product, the total cholesterol, triglyceride and low-density lipoprotein cholesterol level of an object can be remarkably reduced under the action of peste des petits ruminants, and meanwhile, the high-density lipoprotein cholesterol level is increased; in addition, abnormal blood glucose induced by high-fat diet can be improved, arterial lipid accumulation is reduced, and the plaque area proportion of atherosclerotic lesions is improved.

The invention discloses an emotion regulation and sleep improvement method based on audio and video combination and essential oil sniffing, comprising the steps of S1, brain wave detection and state evaluation, S2, audio and video prescription generation, S3, essential oil sniffing, S4, multi-mode coordinated regulation, S5, effect evaluation and strategy optimization, S6, sleep triggering and wakeup intervention, and S7, sleep improvement. And a user interaction and preference setting step. The emotional state is evaluated by collecting the physiological signals of the user, the audio and video prescription and the essential oil formula are dynamically matched based on the evaluation result, time sequence cooperation of audio and video content and essential oil release is achieved, and therefore accurate intervention on emotion and sleep is achieved on the multi-sensory level; self-adaptive adjustment can be carried out according to individual differences of users and real-time feedback, the effects of emotion adjustment and sleep improvement are remarkably improved, meanwhile, side effects of drugs are avoided, and the method has the advantages of being safe, convenient to use and high in individuation.

This invention belongs to the field of supercapacitor technology, specifically relating to a molybdenum oxide-molybdenum disulfide@polytannic acid electrode material, its preparation method, and its applications. Using molybdenum foil as the current collector and electrode, this invention prepares a molybdenum oxide-molybdenum disulfide electrode using electrochemical oxidation and hydrothermal methods. A polytannic acid coating is deposited on its surface to prepare a biodegradable molybdenum oxide-molybdenum disulfide@polytannic acid electrode. This electrode is then sandwiched with a biodegradable gel electrolyte and encapsulated with a biodegradable encapsulation material to construct a biodegradable supercapacitor with self-discharge suppression capabilities. By depositing a polytannic acid coating on the surface of the supercapacitor electrode, its self-discharge behavior is suppressed. The polytannic acid coating can prevent parasitic Faraday reactions of impurity ions on the electrode surface and prevent charge transfer, thereby suppressing the capacitor's self-discharge behavior. Simultaneously, the electrode, electrolyte, and encapsulation material can all degrade in simulated body fluids, potentially opening up applications in implantable medical electronic devices.

The application discloses a pPAM long-circulating liposome, a preparation method and application thereof, and the long-circulating liposome takes a blank liposome as a carrier, internally carries a plasmid pPAM, and is decorated on the surface with a transferrin-penetratin complex Tf-Pen and an oxytocin receptor antibody OTR Ab； The plasmid pPAM carries a cDNA sequence of a peptide acylglycine alpha amidation monooxygenase PAM; and the blank liposome is composed of DSPC, PEG 2000 , cholesterol and lecithin. The application provides a new direction for development of endogenous polypeptide synthesis enzyme delivery technology and mental drugs, and improves the possibility of preparing new anti-anxiety and depression drugs, relieving mental stress and improving patient compliance.

The invention relates to the technical field of biological medicine, in particular to selenium and application of a selenium composition, a nasal composition and application of the nasal composition. The invention provides application of selenium in inhibition of nasal cavity or airway epithelium inflammatory factor expression and a nasal composition containing the selenium. The selenium element is used for regulating and controlling a signal channel, so that the expression of key inflammatory factors in epithelial cells of the nasal cavity or the airway is effectively reduced, the level of reactive oxygen species (ROS) of the epithelial cells of the nasal cavity or the airway is reduced, and the dual effects of inflammation resistance and oxidation resistance are achieved. Therefore, the nasal composition containing the selenium element can effectively block the preinflammatory syndrome driven by upstream oxidative stress by regulating and controlling dual mechanisms of inflammation and oxidative stress reaction, and nasal cavity or airway diseases such as rhinitis and allergic rhinitis are relieved and treated from the source.

This invention discloses the application of a PDLIM2 gene overexpression viral vector in the preparation of drugs for treating podocyte disease, wherein the nucleotide sequence of the PDLIM2 gene is shown in SEQ ID NO:1. This invention is the first to discover and verify the core role of the PDLIM2 gene in podocyte protection, confirming its significant downregulation in DKD and FSGS disease models, and demonstrating through functional experiments that PDLIM2 overexpression can effectively stabilize the podocyte cytoskeleton, inhibit apoptosis, and reduce proteinuria, thus establishing it as a key target gene for the treatment of podocyte disease. This invention is the first to intervene at the gene level in the core link of podocyte damage—cytoskeleton stability. By specifically upregulating the expression of PDLIM2 in podocytes, it directly enhances their intrinsic cytoskeleton support and anti-damage ability, achieving a fundamental shift in treatment strategy from "symptomatic support" to "causal repair."

The application discloses a trispecific natural killer cell engager molecule and application thereof, and relates to the technical field of biotechnology and medicine, and comprises at least three functional domains: a first binding domain which is composed of an extracellular domain of an NKG2D receptor capable of specifically binding to an NKG2D ligand; a second binding domain which is composed of interleukin-15 or a functional fragment thereof; and a third binding domain which is composed of a fragment capable of specifically recognizing an NK cell activating receptor CD16, wherein the second binding domain is located between the first binding domain and the third binding domain, and each binding domain is sequentially connected by a connecting peptide or directly fused by a peptide bond. The engager molecule can significantly enhance the killing activity of natural killer (NK) cells on target cells expressing NKG2D ligands, and can be used as an effective drug for treating various diseases related to NKG2D ligand expression, including but not limited to aging-related diseases, tumors and virus infection-related diseases.

The invention relates to the technical field of preparation of cleansing products, in particular to a formula and a preparation method of skin-refreshing cleansing oil, and the skin-refreshing cleansing oil is characterized in that fatty acid ester components and polyoxyethylene ether surfactants in a system are balanced by adjusting the proportion of cetyl alcohol ethyl hexanoate to PEG-8 diisostearate; after the proportion is adjusted, the dosage of sorbitol polyether-30 tetraoleate is increased to 7%, and the strength of an interfacial film is improved; and tocopherol is added as an antioxidant substance, so that the risk of emulsification collapse caused by oxidation stability is reduced. According to the skin-refreshing cleansing oil formula and the preparation method, the strength of an interfacial film is enhanced by increasing the dosage of sorbitol polyether-30 tetraoleate, oxidation is inhibited by adding tocopherol, the content of squalane is dynamically adjusted by combining the proportion of polar / non-polar components, emulsification collapse and layering are effectively avoided, and it is ensured that the product is kept in a stable state in the storage and use process.

This invention discloses a method for preparing an in-situ reinforced single-atom nanoenzyme bactericidal composite material for concrete. The method includes using sodium ferric ethylenediaminetetraacetate (EDTA) as a core precursor, and encapsulating calcium peroxide on its surface through an in-situ reaction to form a composite precursor of calcium peroxide encapsulating EDTA; directional hydrolysis of tetraethyl orthosilicate (TEOS) to form a thin layer of silica on the surface of the composite precursor; subsequent calcination under an inert gas to obtain a three-layer core-shell composite material of single-atom iron nanoenzyme / porous calcium peroxide / porous silica; and finally, grafting with aminosilane to obtain a three-layer core-shell composite material of single-atom iron nanoenzyme / porous calcium peroxide / porous silica with surface-grafted aminosilane. The composite material prepared by this method can achieve continuous and efficient bactericidal action in concrete while increasing nucleation sites, promoting hydration, and effectively improving the early strength and durability of concrete.

The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine compound and preparation for treating coronary heart disease and a preparation method and application of the traditional Chinese medicine compound and preparation. The traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10-30 parts of astragalus membranaceus, 5-15 parts of rhodiola rosea, 10-30 parts of salvia miltiorrhiza, 5-15 parts of ligusticum wallichii, 10-30 parts of trichosanthes kirilowii maxim, 5-15 parts of allium macrostemon, 5-15 parts of folium ginkgo, 10-30 parts of radix puerariae, 10-30 parts of radix ophiopogonis, 3-10 parts of schisandra chinensis, 15-30 parts of oyster, 5-15 parts of cassia twig and 3-10 parts of liquorice. Animal experiment results show that the traditional Chinese medicine composition provided by the invention has remarkable and multi-aspect curative effect advantages in the aspect of treating a coronary heart disease rat model. The traditional Chinese medicine composition not only can enhance myocardial contractility and recover heart blood pumping function, but also can inhibit inflammatory response, relieve myocardial damage, effectively relieve myocardial structure damage and protect myocardial tissue integrity. In addition, a proportional experiment result shows that the effect of the composition provided by the invention can be obviously weakened by losing any medicine pair, so that all the medicines in the formula cannot be absent.

The invention relates to the technical field of microorganisms, and particularly discloses lactobacillus delbrueckii subsp. Bulgaricus KFSY10 and application thereof in the aspect of improving the immune function, the lactobacillus delbrueckii subsp. Bulgaricus KFSY10 is preserved in the China General Microbiological Culture Collection Center on May 2, 2018, the preservation address is CGMCC (China General Microbiological Culture Collection Center), and the preservation number is CGMCC NO. The Lactobacillus delbrueckii subsp. Bulgaricus is located in Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing, has a preservation number of CGMCCNO: 15717, and is classified and named as Lactobacillus delbrueckii subsp. Bulgaricus KFSY10. The lactobacillus delbrueckii subsp. Bulgaricus KSFY10 provided by the invention can be used for directly improving the immune function of an immunosuppressive mouse by protecting and maintaining normal physiological structures of central and peripheral immune organs and promoting secretion of serum cytokines and immune globulins; and the immunologic function of the mouse can be indirectly promoted by regulating and controlling acute and chronic inflammatory reactions of intestinal tracts, so that side effects and adverse reactions caused by the use of chemical drugs are effectively avoided.

The invention discloses a flavonoid composition for targeted regulation and control of TSLP-TSLPR and application of the flavonoid composition, the flavonoid composition is prepared from kaempferol, kaempferol-7-O-glucoside and kaempferol-7-O-rhamnoside, and the molar ratio of the kaempferol to the kaempferol-7-O-rhamnoside is (1-3): (1-3): (1-3). According to the composition, generation of key cytokines IL-4 and IL-13 of allergic inflammation is remarkably inhibited by blocking a TSLP-TSLPR signal channel, so that allergic skin diseases such as TSLP-mediated atopic dermatitis, urticaria and psoriasis are effectively treated. In action mechanism research, in-vitro experiments show that when the three components are combined according to the ratio of 2: 3: 1, the strongest inhibition effect on TSLP-induced IL-4 and IL-13 secretion in a HuT78 cell model is achieved, and the effect is remarkably superior to that of a single-component treatment group. According to the invention, the action limitation of a single flavone component is broken through, the efficient targeted regulation and control of the TSLP-TSLPR pathway is realized through the synergistic effect of multiple components with accurate proportioning, and a safe and effective treatment scheme is provided for allergic skin diseases.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

This invention relates to the field of organic synthesis technology, and discloses a copper-based catalyst, its preparation method, and a method for catalyzing the preparation of cyclododecanol from cyclododecanol into cyclododecanone. The preparation method of the copper-based catalyst includes the following steps: preparing a catalyst with a specific surface area of ​​200-250 m² / g. 2 / g Al2O3-SiO2 composite support; copper source and rare earth oxide additives were loaded onto the Al2O3-SiO2 composite support, dried and calcined to obtain catalyst precursor; the catalyst precursor was reduced to prepare Cu + A copper-based catalyst with a molar ratio of 1.8 to 2.5:1 to elemental copper. This invention can control the Cu content in the copper-based catalyst. + The molar ratio with elemental copper allows the catalyst's activity state to be adjusted according to different production needs, thereby enabling flexible control of the reaction rate, improving process adaptability and operational stability; at the same time, it helps to suppress side reactions and improve the selectivity and purity of cyclododecanone.

The invention relates to the technical field of medicinal and edible products, and discloses medicinal and edible paste capable of improving gastric motility insufficiency, the medicinal and edible paste is hawthorn and pericarpium citri reticulatae six-ingredient paste, and the hawthorn and pericarpium citri reticulatae six-ingredient paste comprises, by weight, 8-12 g of raw malt, 8-12 g of pericarpium citri reticulatae, 13-17 g of fructus citri stir-fried with honey and bran, 4-6 g of perilla leaves, 4-6 g of agastache rugosus and 13-17 g of hawthorn. The six raw materials are all medicinal and edible substances, common side effects of chemical drugs are avoided, multiple effects of regulating qi (dried tangerine or orange peel and citron), harmonizing stomach (perilla leaves), promoting digestion (hawthorn and malt), tonifying spleen (wrinkled gianthyssop herb and malt), soothing liver (citron) and the like are taken into consideration, and synergistic interaction instead of single target effect is achieved aiming at core pathogenesis (liver depression, qi stagnation and weakness of spleen and stomach) of gastric motility deficiency. The oral liquid can be directly taken orally or brewed with warm water, the use pain point under the scenes of going out, traveling, working and the like is solved, and the user experience is improved.

This application discloses a method for synthesizing 2,6-difluorostyrene, belonging to the field of organic chemical synthesis technology, including the following steps: (1) 2,6-dichlorobenzonitrile undergoes a halogen exchange fluorination reaction with a fluorinating agent in a polar aprotic solvent to obtain 2,6-difluorobenzonitrile; (2) the obtained 2,6-difluorobenzonitrile undergoes an addition reaction with methyl magnesium halide in an inert solvent, followed by hydrolysis to obtain 2,6-difluoroacetophenone; (3) the obtained 2,6-difluoroacetophenone undergoes a carbonyl reduction reaction in a solvent to obtain 1-(2,6-difluorophenyl)ethanol; (4) the obtained 1-(2,6-difluorophenyl)ethanol undergoes a dehydration reaction in an alkane solvent under protic acid catalysis to obtain 2,6-difluorostyrene. This synthesis method has the advantages of inexpensive and readily available raw materials, good atom economy, simple reaction operation, high synthesis yield, and good product purity, making it suitable for industrial application.

The application discloses an anticoagulant material, which is based on enzyme-like catalytic reaction to produce nitric oxide, dinitrogen trioxide, nitrous acid and / or other similar substances with anticoagulant function, so as to improve the anticoagulant effect of a blood-contacting medical device or medical material surface. The application also discloses related medical devices or medical materials, and preparation methods and uses thereof. The anticoagulant coating of the blood-contacting medical device surface provided by the application based on enzyme-like catalytic reaction to produce nitric oxide or similar substances has excellent service effect, and can solve the problems of poor biocompatibility, easy blood coagulation on the surface, and the need to cooperate with anticoagulant drugs with large side effects of the blood-contacting medical device for a long time.

The invention discloses a veterinary drug additive carrier and a production process and application thereof, and relates to the technical field of pharmaceutical preparations, the production process comprises the following steps: 1, adding beta-cyclodextrin and epichlorohydrin into a Tris-HCl buffer solution, uniformly mixing in a constant-temperature water bath, adding a catalyst in batches, carrying out microwave radiation, dialyzing and purifying, and freeze-drying to form a molecular inclusion layer, so as to obtain a beta-cyclodextrin / epichlorohydrin composite material; the beta-cyclodextrin cross-linked polymer is obtained; 2, ball-milling and mixing a beta-cyclodextrin cross-linked polymer and a silica gel nano-composite to obtain a carrier; the carrier is applied to veterinary drugs, beta-cyclodextrin is carboxylated, then a carboxyl-containing beta-cyclodextrin cross-linked polymer is prepared, NHS is introduced, guanidyl modified chitosan is introduced into a silica gel nanocomposite, amino in the silica gel nanocomposite and NHS in the beta-cyclodextrin cross-linked polymer can form a stable amido bond, and the guanidyl modified chitosan is added into the silica gel nanocomposite. The separation of the carrier material in the subsequent processing is avoided, and the effect of the medicine in the body is synergistically improved.

The invention discloses application of a PDLIM2 gene overexpression virus vector in preparation of a medicine for treating podocytosis. The nucleotide sequence of a PDLIM2 gene is as shown in SEQ ID NO: 1. The core effect of the PDLIM2 gene in podocytosis protection is found and verified for the first time, it is confirmed that the expression of the PDLIM2 gene in DKD and FSGS disease models is remarkably reduced, and functional experiments prove that the overexpression of the PDLIM2 can effectively stabilize podocytoskeleton, inhibit apoptosis and relieve proteinuria, so that the PDLIM2 gene is determined as a key target gene for treating podocytosis. According to the invention, the stability of the cytoskeleton, which is a core link of podocyte injury, is intervened from the gene level for the first time. The expression of the PDLIM2 in the podocyte is specifically up-regulated, so that the internal cytoskeleton support and damage resistance of the podocyte are directly enhanced, and the fundamental treatment strategy conversion from symptomatic support to cause repair is realized.

A kind of gel material for reducing bladder stone formation and its preparation method and application, the raw materials of the gel material include temperature-sensitive component Pluronic F127, photo-crosslinking component methacrylated gelatin and active functional ingredient cerium dioxide nanoparticles.The gel material is liquid at low temperature, which is convenient for perfusion into bladder through catheter;It quickly changes into physical gel at body temperature, realizing in-situ forming;Then it occurs photo-crosslinking through ultraviolet irradiation, forming chemical crosslinking gel with high mechanical strength and good stability, which can resist urine flushing and realize long-term residence.Loaded cerium dioxide nanoparticles continuously remove reactive oxygen species in stone formation microenvironment by simulating catalase and superoxide dismutase activity, thereby inhibiting the nucleation, growth and aggregation of crystals.The material has excellent biocompatibility, simple preparation method, can significantly reduce bladder stone formation, and has broad application prospect in preventing postoperative recurrence of bladder stone and conservative treatment.

The invention discloses an application of a PD-L1 single-domain antibody in preparation of a preparation for promoting hair growth or preventing and treating alopecia, belongs to the technical field of biological medicines, and particularly discloses an effect of the PD-L1 single-domain antibody in regulation and control of expression of cytokines IL-6 and Leptin so as to activate a JAK-STAT signal channel and provides a new preparation source for treatment of non-scar alopecia. The invention further provides a preparation containing the PD-L1 single-domain antibody, the side effect of an existing medicine for treating alopecia can be overcome, the treatment effect is good, and after a subject takes the medicine for 3-4 times and 8 weeks after the medicine is stopped, hair growth at the original alopecia position still continues.

The present application relates to a small nucleic acid combination microneedle preparation method and its skin light damage repair purposes, specifically discloses a microneedle composition, including the complex of SNAP25 specific siRNA and nano selenium and hyaluronic acid, wherein the nucleotide sequence of the sense strand of siRNA is as shown in SEQ ID NO.1, and the nucleotide sequence of the antisense strand of siRNA is as shown in SEQ ID NO.2.The microneedle composition of the present application can realize the stable delivery of siRNA, inhibit the expression of UV-induced skin photoaging related genes, increase the repair of skin extracellular matrix, significantly improve the skin light damage, and is suitable for clinical transformation application.

The invention discloses synergistic compound essential oil for treating and preventing tinea pedis and a preparation method of the synergistic compound essential oil, and belongs to the technical field of skin care and antifungal of essential oil. The compound essential oil takes jojoba oil as base oil (added to 100%), and is compounded with the following single essential oil in percentage by weight: 0.5-9.0% of juniper essential oil, 0.5-8.9% of lemongrass essential oil, 0.5-9.3% of geranium essential oil and 0.5-8.7% of chamomile essential oil. The compound essential oil has dual effects of treatment and prevention, can quickly relieve symptoms such as pruritus, desquamation and blister caused by tinea pedis, can inhibit fungus breeding and reduce the recurrence rate after being used for a long time, is mild and non-irritant, is skin-friendly and easy to absorb, is convenient to use, and is suitable for daily foot care and prevention and adjuvant treatment of tinea pedis. The product is natural, safe and remarkable in effect, and an excellent natural solution is provided for solving the problem that drug resistance and side effects are easily generated when tinea pedis is treated by chemical drugs.

The application discloses a portable magnetic snore stopper and belongs to the technical field of snore stoppers. The magnetic snore stopper comprises a plurality of mouthpiece sets, the plurality of mouthpiece sets are arranged in two groups of mirror images, the two groups of mirror image arranged mouthpiece sets are upper mouthpiece sets and lower mouthpiece sets, the mouthpiece sets are arranged in a fan-shaped structure, a through hole is formed in one side of the mouthpiece sets, a self-adapting mouthpiece adjusting assembly is arranged in the through hole, the self-adapting mouthpiece adjusting assembly is used for fitting the teeth and oral cavity structure of users with different tooth shapes, a mandibular trigger support assembly is mounted on the side, away from the mouthpiece set, of the self-adapting mouthpiece adjusting assembly, and the mandibular trigger support assembly is used for adaptively adjusting the lower jaw position. Through the self-adapting mouthpiece adjusting assembly and the mandibular trigger support assembly, the comfortable nature is ensured, the treatment effect is improved, the oral cavity conditions of different users can be adapted, the production cost is reduced, and different degrees of snoring problems can be effectively solved.

This application provides a method and system for drying semi-coke using waste heat from flue gas, relating to the technical field of semi-coke drying. The method includes: real-time detection of the moisture content of semi-coke at the outlet of the semi-coke dryer; when the moisture content is greater than a preset moisture content threshold, acquiring the drying data for the current batch; calculating a first theoretical moisture content based on a drying kinetic model of the current batch of drying data; generating perturbation data by applying a small disturbance to the drying data of the current batch, and calculating a second theoretical moisture content based on the perturbation data of the drying kinetic model of the drying kinetic model of the second batch of drying data; determining the perturbation difference based on the first theoretical moisture content and the second theoretical moisture content, and determining the perturbation coefficient based on the perturbation difference and the small perturbation; and determining parameter adjustment data based on the perturbation coefficient and a preset optimization objective function. This method, to a certain extent, solves the problem in the prior art where static prediction models cannot adapt to dynamic changes in the drying process conditions, leading to a decrease in control accuracy.

The invention provides an IPS cell-derived BDNF recombinant expression vector and application thereof, and relates to the technical field of gene engineering and cell therapy, the recombinant expression vector comprises a recombinant expression cassette, and the recombinant expression cassette comprises an A beta pathological characteristic responsive promoter and a BDNF coding sequence; the A beta pathological characteristic responsive promoter is selected from an IL-1beta promoter or a TNF-alpha promoter; the A [beta] pathological characteristic responsive promoter can drive the expression of a BDNF coding sequence in an A [beta] deposition induced inflammation microenvironment. According to the vector, an IL-1beta or TNF-alpha promoter is utilized to respond to an A beta-induced inflammatory microenvironment, specific expression of BDNF in a pathological injury area is achieved, silence is kept in healthy tissue, and nervous excitatory toxicity caused by non-targeted overexpression is effectively avoided. The expression level can be dynamically adjusted along with the intensity of an inflammation signal, on-demand release of matched pathology severity is realized, and the targeting accuracy and safety of treatment are remarkably improved.