5results about How to "Increased proliferation" patented technology

This invention discloses a collagen-based anti-corrosion coating with tissue repair properties, its preparation method, and its applications, belonging to the field of medical coating technology. This invention designs a novel self-healing anti-corrosion coating and loads collagen onto the coating using excipients, achieving a deep integration of anti-corrosion protection and biological function. The prepared collagen-based anti-corrosion coating is firmly bonded to a magnesium alloy substrate via covalent bonds. After 4 weeks of in vivo implantation, no cracking or detachment was observed, the stent structure maintained good integrity, and it provides continuous radial support, offering sufficient time for vascular repair. This provides a feasible solution for the clinical translation of next-generation biodegradable magnesium-based vascular stents.

The invention belongs to the technical field of biological medicines, discloses an application of a Sema3E inhibitor in preparation of a medicine for preventing, delaying or treating COPD small airway fibrosis, and proposes that the Sema3E inhibitor can be used for treating, preventing or delaying the COPD small airway fibrosis for the first time. The Sema3E inhibitor plays a role by inhibiting the expression of Sema3E. The specific molecular mechanism is as follows: by inhibiting the expression of Sema3E, inhibiting the expression of Wnt5a / b, beta-Catenin, increasing the expression of p-beta-Catenin, inhibiting the activation of a Wnt / beta-Catenin pathway, and inhibiting the activation / proliferation / migration of small airway fibroblasts. Through the mechanism, the effect of preventing, delaying or treating the COPD is achieved, and a new drug intervention target, namely Sema3E, is provided for treatment of the COPD.

The invention discloses a complete mixing continuous flow anaerobic ammonia oxidation sludge reinforced granulation device and method, and belongs to the technical field of wastewater biological denitrification. The device takes a complete mixing continuous flow reactor as a core, and is provided with a monitoring control platform, a temperature control device, a pH regulating agent tank and a nutrient solution agent tank. A magnetic suspension stirring device is arranged at the bottom of the reactor and comprises a stirring rotor arranged in an inner cavity of the reactor and a magnetic suspension motor fixed to the outer side of the bottom of the reactor, the magnetic suspension motor drives the stirring rotor to rotate in a magnetic coupling mode without a penetrating shaft, and a strict anaerobic and high-shear mixing environment is constructed for anaerobic ammonium oxidation bacteria. A detachable sludge blocking baffle is arranged on an effluent weir at the upper part of the reactor, and sieve plates with different apertures can be replaced according to operation stages, so that efficient interception and backflow of granular sludge with different particle sizes under a continuous flow condition are realized. On-line monitoring and automatic control are integrated, the anaerobic ammonia oxidation sludge granulation process is effectively promoted, and it is guaranteed that the system stably runs for a long time under the continuous flow condition.

The invention provides a composition for preventing bone loss caused by cold exposure as well as a preparation method and application of the composition, and belongs to the technical field of pharmaceutical compositions. The composition provided by the invention is prepared from the following components in parts by weight: 1.18 to 1.58 parts of radix angelicae sinensis extract, 1.18 to 1.58 parts of flos carthami extract, 1.18 to 1.58 parts of semen persicae extract and 2.56 to 2.96 parts of fructus crataegi extract. The preparation method of the composition comprises the following steps: weighing the polymer carrier, adding the polymer carrier into precooled purified water, and adding ethanol; weighing a raw material mixture, and adding the raw material mixture into the polymer solution; performing spray drying to obtain fine powder, and performing vacuum drying to obtain the composition for preventing bone loss caused by cold exposure. The composition for preventing bone loss caused by cold exposure, prepared by the invention, has high solubility and high dissolution rate, and active ingredients take effect quickly; the bone loss caused by cold exposure can be prevented.

The invention relates to the technical field of biology, in particular to application of a CDH18 gene serving as a target spot to screening of drugs for preventing or treating cervical cancer, the drugs take the CDH18 gene as the target spot, expression of the CDH18 gene is inhibited or silenced, the proliferation and migration capacity of cervical cancer cells can be enhanced by regulating and controlling a Wnt pathway through overexpression of the CDH18 gene, and the drugs for preventing or treating cervical cancer can be used for preventing or treating cervical cancer. The down-regulation of the CDH18 gene inhibits the expression of beta-catenin, the knock-down of the CDH18 gene can inhibit the proliferation and migration ability of cervical cancer cells by regulating and controlling a Wnt signal pathway, the kaempferide has a certain potential anti-tumor activity effect in the cervical cancer cells, the kaempferide can induce the apoptosis of SiHa and HeLa cells of cervical cancer, and the kaempferide can inhibit the proliferation and migration ability of the cervical cancer cells. Experiments show that the kaempferide inhibits the expression level of Wnt signal pathway related molecules by reducing the expression level of CDH18, further promotes apoptosis of cervical cancer cells and inhibits proliferation and migration of the cervical cancer cells.